ID   NK2R_MOUSE              Reviewed;         384 AA.
AC   P30549;
DT   01-APR-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-APR-1993, sequence version 1.
DT   27-MAR-2024, entry version 178.
DE   RecName: Full=Substance-K receptor;
DE            Short=SKR;
DE   AltName: Full=NK-2 receptor;
DE            Short=NK-2R;
DE   AltName: Full=Neurokinin A receptor;
DE   AltName: Full=Tachykinin receptor 2;
GN   Name=Tacr2; Synonyms=Tac2r;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Intestine;
RX   PubMed=1370937; DOI=10.1111/j.1432-1033.1992.tb16592.x;
RA   Sundelin J.B., Provvedini D.M., Wahlestedt C.R., Laurell H., Pohl J.S.,
RA   Peterson P.A.;
RT   "Molecular cloning of the murine substance K and substance P receptor
RT   genes.";
RL   Eur. J. Biochem. 203:625-631(1992).
CC   -!- FUNCTION: This is a receptor for the tachykinin neuropeptide substance
CC       K (neurokinin A). It is associated with G proteins that activate a
CC       phosphatidylinositol-calcium second messenger system. The rank order of
CC       affinity of this receptor to tachykinins is: substance K > neuromedin-K
CC       > substance P.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR   EMBL; X62933; CAA44706.1; -; mRNA.
DR   CCDS; CCDS35919.1; -.
DR   PIR; S20303; S20303.
DR   RefSeq; NP_033340.3; NM_009314.4.
DR   AlphaFoldDB; P30549; -.
DR   SMR; P30549; -.
DR   STRING; 10090.ENSMUSP00000020278; -.
DR   BindingDB; P30549; -.
DR   ChEMBL; CHEMBL2813; -.
DR   GlyCosmos; P30549; 1 site, No reported glycans.
DR   GlyGen; P30549; 1 site.
DR   iPTMnet; P30549; -.
DR   PhosphoSitePlus; P30549; -.
DR   PaxDb; 10090-ENSMUSP00000020278; -.
DR   ProteomicsDB; 293852; -.
DR   Antibodypedia; 1518; 334 antibodies from 36 providers.
DR   DNASU; 21337; -.
DR   Ensembl; ENSMUST00000020278.6; ENSMUSP00000020278.6; ENSMUSG00000020081.6.
DR   GeneID; 21337; -.
DR   KEGG; mmu:21337; -.
DR   UCSC; uc007fgx.2; mouse.
DR   AGR; MGI:98477; -.
DR   CTD; 6865; -.
DR   MGI; MGI:98477; Tacr2.
DR   VEuPathDB; HostDB:ENSMUSG00000020081; -.
DR   eggNOG; KOG4219; Eukaryota.
DR   GeneTree; ENSGT00940000155512; -.
DR   HOGENOM; CLU_009579_6_1_1; -.
DR   InParanoid; P30549; -.
DR   OMA; RRVNRCH; -.
DR   OrthoDB; 2912851at2759; -.
DR   PhylomeDB; P30549; -.
DR   TreeFam; TF315303; -.
DR   Reactome; R-MMU-380095; Tachykinin receptors bind tachykinins.
DR   Reactome; R-MMU-416476; G alpha (q) signalling events.
DR   BioGRID-ORCS; 21337; 0 hits in 76 CRISPR screens.
DR   PRO; PR:P30549; -.
DR   Proteomes; UP000000589; Chromosome 10.
DR   RNAct; P30549; Protein.
DR   Bgee; ENSMUSG00000020081; Expressed in kidney vasculature and 24 other cell types or tissues.
DR   ExpressionAtlas; P30549; baseline and differential.
DR   GO; GO:0005886; C:plasma membrane; ISO:MGI.
DR   GO; GO:0036126; C:sperm flagellum; ISO:MGI.
DR   GO; GO:0061827; C:sperm head; ISO:MGI.
DR   GO; GO:0097225; C:sperm midpiece; ISO:MGI.
DR   GO; GO:0016497; F:substance K receptor activity; ISO:MGI.
DR   GO; GO:0014827; P:intestine smooth muscle contraction; ISO:MGI.
DR   GO; GO:0033685; P:negative regulation of luteinizing hormone secretion; ISO:MGI.
DR   GO; GO:0035106; P:operant conditioning; ISO:MGI.
DR   GO; GO:0014057; P:positive regulation of acetylcholine secretion, neurotransmission; ISO:MGI.
DR   GO; GO:1902093; P:positive regulation of flagellated sperm motility; ISO:MGI.
DR   GO; GO:0043270; P:positive regulation of monoatomic ion transport; ISO:MGI.
DR   GO; GO:0070474; P:positive regulation of uterine smooth muscle contraction; ISO:MGI.
DR   GO; GO:0043117; P:positive regulation of vascular permeability; ISO:MGI.
DR   GO; GO:0070459; P:prolactin secretion; ISO:MGI.
DR   GO; GO:0070472; P:regulation of uterine smooth muscle contraction; IDA:CACAO.
DR   GO; GO:0051602; P:response to electrical stimulus; IEA:Ensembl.
DR   CDD; cd16004; 7tmA_SKR_NK2R; 1.
DR   Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR001681; Neurokn_rcpt.
DR   InterPro; IPR000913; NK2_rcpt.
DR   PANTHER; PTHR46925; G-PROTEIN COUPLED RECEPTOR TKR-1-RELATED; 1.
DR   PANTHER; PTHR46925:SF3; SUBSTANCE-K RECEPTOR; 1.
DR   Pfam; PF00001; 7tm_1; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR01025; NEUROKININ2R.
DR   PRINTS; PR00244; NEUROKININR.
DR   SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
DR   Genevisible; P30549; MM.
PE   2: Evidence at transcript level;
KW   Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW   Lipoprotein; Membrane; Palmitate; Receptor; Reference proteome; Transducer;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..384
FT                   /note="Substance-K receptor"
FT                   /id="PRO_0000069895"
FT   TOPO_DOM        1..32
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        33..56
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        57..69
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        70..90
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        91..107
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        108..129
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        130..149
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        150..170
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        171..196
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        197..218
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        219..251
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        252..272
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        273..290
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        291..310
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        311..384
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   REGION          365..384
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   LIPID           324
FT                   /note="S-palmitoyl cysteine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        19
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        106..181
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ   SEQUENCE   384 AA;  43114 MW;  7937F05A2BB90759 CRC64;
     MGAHASVTDT NILSGLESNA TGVTAFSMPG WQLALWATAY LALVLVAVTG NATVIWIILA
     HERMRTVTNY FIINLALADL CMAAFNATFN FIYASHNIWY FGSTFCYFQN LFPVTAMFVS
     IYSMTAIAAD RYMAIVHPFQ PRLSAPSTKA VIAVIWLVAL ALASPQCFYS TITVDQGATK
     CVVAWPNDNG GKMLLLYHLV VFVLIYFLPL VVMFAAYSVI GLTLWKRAVP RHQAHGANLR
     HLQAKKKFVK AMVLVVVTFA ICWLPYHLYF ILGTFQEDIY YRKFIQQVYL ALFWLAMSST
     MYNPIIYCCL NHRFRSGFRL AFRCCPWGTP TEEDRLELTH TPSISRRVNR CHTKETLFMT
     GDMTHSEATN GQVGGPQDGE PAGP
//