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Protein

Substance-K receptor

Gene

Tacr2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

This is a receptor for the tachykinin neuropeptide substance K (neurokinin A). It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: substance K > neuromedin-K > substance P.

GO - Molecular functioni

  1. substance K receptor activity Source: Ensembl

GO - Biological processi

  1. intestine smooth muscle contraction Source: Ensembl
  2. negative regulation of luteinizing hormone secretion Source: Ensembl
  3. operant conditioning Source: Ensembl
  4. positive regulation of acetylcholine secretion, neurotransmission Source: Ensembl
  5. positive regulation of uterine smooth muscle contraction Source: Ensembl
  6. positive regulation of vascular permeability Source: Ensembl
  7. prolactin secretion Source: Ensembl
  8. response to electrical stimulus Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_207651. G alpha (q) signalling events.
REACT_252339. Tachykinin receptors bind tachykinins.

Names & Taxonomyi

Protein namesi
Recommended name:
Substance-K receptor
Short name:
SKR
Alternative name(s):
NK-2 receptor
Short name:
NK-2R
Neurokinin A receptor
Tachykinin receptor 2
Gene namesi
Name:Tacr2
Synonyms:Tac2r
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 10

Organism-specific databases

MGIiMGI:98477. Tacr2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3232ExtracellularSequence AnalysisAdd
BLAST
Transmembranei33 – 5624Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini57 – 6913CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei70 – 9021Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini91 – 10717ExtracellularSequence AnalysisAdd
BLAST
Transmembranei108 – 12922Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini130 – 14920CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei150 – 17021Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini171 – 19626ExtracellularSequence AnalysisAdd
BLAST
Transmembranei197 – 21822Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini219 – 25133CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei252 – 27221Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini273 – 29018ExtracellularSequence AnalysisAdd
BLAST
Transmembranei291 – 31020Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini311 – 38474CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 384384Substance-K receptorPRO_0000069895Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi19 – 191N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi106 ↔ 181PROSITE-ProRule annotation
Lipidationi324 – 3241S-palmitoyl cysteineSequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PRIDEiP30549.

PTM databases

PhosphoSiteiP30549.

Expressioni

Gene expression databases

BgeeiP30549.
CleanExiMM_TACR2.
ExpressionAtlasiP30549. baseline and differential.
GenevestigatoriP30549.

Interactioni

Structurei

3D structure databases

ProteinModelPortaliP30549.
SMRiP30549. Positions 9-341.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG331485.
HOGENOMiHOG000013018.
HOVERGENiHBG103412.
InParanoidiP30549.
KOiK04223.
OMAiLCMAAFN.
OrthoDBiEOG7N37FW.
PhylomeDBiP30549.
TreeFamiTF315303.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001681. Neurokn_rcpt.
IPR000913. NK2_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01025. NEUROKININ2R.
PR00244. NEUROKININR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P30549-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGAHASVTDT NILSGLESNA TGVTAFSMPG WQLALWATAY LALVLVAVTG
60 70 80 90 100
NATVIWIILA HERMRTVTNY FIINLALADL CMAAFNATFN FIYASHNIWY
110 120 130 140 150
FGSTFCYFQN LFPVTAMFVS IYSMTAIAAD RYMAIVHPFQ PRLSAPSTKA
160 170 180 190 200
VIAVIWLVAL ALASPQCFYS TITVDQGATK CVVAWPNDNG GKMLLLYHLV
210 220 230 240 250
VFVLIYFLPL VVMFAAYSVI GLTLWKRAVP RHQAHGANLR HLQAKKKFVK
260 270 280 290 300
AMVLVVVTFA ICWLPYHLYF ILGTFQEDIY YRKFIQQVYL ALFWLAMSST
310 320 330 340 350
MYNPIIYCCL NHRFRSGFRL AFRCCPWGTP TEEDRLELTH TPSISRRVNR
360 370 380
CHTKETLFMT GDMTHSEATN GQVGGPQDGE PAGP
Length:384
Mass (Da):43,114
Last modified:April 1, 1993 - v1
Checksum:i7937F05A2BB90759
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X62933 mRNA. Translation: CAA44706.1.
CCDSiCCDS35919.1.
PIRiS20303.
RefSeqiNP_033340.3. NM_009314.4.
UniGeneiMm.8054.

Genome annotation databases

EnsembliENSMUST00000020278; ENSMUSP00000020278; ENSMUSG00000020081.
GeneIDi21337.
KEGGimmu:21337.
UCSCiuc007fgx.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X62933 mRNA. Translation: CAA44706.1.
CCDSiCCDS35919.1.
PIRiS20303.
RefSeqiNP_033340.3. NM_009314.4.
UniGeneiMm.8054.

3D structure databases

ProteinModelPortaliP30549.
SMRiP30549. Positions 9-341.
ModBaseiSearch...
MobiDBiSearch...

Chemistry

BindingDBiP30549.
ChEMBLiCHEMBL2813.
GuidetoPHARMACOLOGYi361.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiP30549.

Proteomic databases

PRIDEiP30549.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000020278; ENSMUSP00000020278; ENSMUSG00000020081.
GeneIDi21337.
KEGGimmu:21337.
UCSCiuc007fgx.2. mouse.

Organism-specific databases

CTDi6865.
MGIiMGI:98477. Tacr2.

Phylogenomic databases

eggNOGiNOG331485.
HOGENOMiHOG000013018.
HOVERGENiHBG103412.
InParanoidiP30549.
KOiK04223.
OMAiLCMAAFN.
OrthoDBiEOG7N37FW.
PhylomeDBiP30549.
TreeFamiTF315303.

Enzyme and pathway databases

ReactomeiREACT_207651. G alpha (q) signalling events.
REACT_252339. Tachykinin receptors bind tachykinins.

Miscellaneous databases

NextBioi300504.
PROiP30549.
SOURCEiSearch...

Gene expression databases

BgeeiP30549.
CleanExiMM_TACR2.
ExpressionAtlasiP30549. baseline and differential.
GenevestigatoriP30549.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001681. Neurokn_rcpt.
IPR000913. NK2_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01025. NEUROKININ2R.
PR00244. NEUROKININR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Molecular cloning of the murine substance K and substance P receptor genes."
    Sundelin J.B., Provvedini D.M., Wahlestedt C.R., Laurell H., Pohl J.S., Peterson P.A.
    Eur. J. Biochem. 203:625-631(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Intestine.

Entry informationi

Entry nameiNK2R_MOUSE
AccessioniPrimary (citable) accession number: P30549
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: January 7, 2015
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.