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P30549

- NK2R_MOUSE

UniProt

P30549 - NK2R_MOUSE

Protein

Substance-K receptor

Gene

Tacr2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 119 (01 Oct 2014)
      Sequence version 1 (01 Apr 1993)
      Previous versions | rss
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    Functioni

    This is a receptor for the tachykinin neuropeptide substance K (neurokinin A). It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: substance K > neuromedin-K > substance P.

    GO - Molecular functioni

    1. substance K receptor activity Source: Ensembl

    GO - Biological processi

    1. intestine smooth muscle contraction Source: Ensembl
    2. negative regulation of luteinizing hormone secretion Source: Ensembl
    3. operant conditioning Source: Ensembl
    4. positive regulation of acetylcholine secretion, neurotransmission Source: Ensembl
    5. positive regulation of uterine smooth muscle contraction Source: Ensembl
    6. positive regulation of vascular permeability Source: Ensembl
    7. prolactin secretion Source: Ensembl

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Enzyme and pathway databases

    ReactomeiREACT_207651. G alpha (q) signalling events.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Substance-K receptor
    Short name:
    SKR
    Alternative name(s):
    NK-2 receptor
    Short name:
    NK-2R
    Neurokinin A receptor
    Tachykinin receptor 2
    Gene namesi
    Name:Tacr2
    Synonyms:Tac2r
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 10

    Organism-specific databases

    MGIiMGI:98477. Tacr2.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 384384Substance-K receptorPRO_0000069895Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi19 – 191N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi106 ↔ 181PROSITE-ProRule annotation
    Lipidationi324 – 3241S-palmitoyl cysteineSequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

    Proteomic databases

    PRIDEiP30549.

    PTM databases

    PhosphoSiteiP30549.

    Expressioni

    Gene expression databases

    ArrayExpressiP30549.
    BgeeiP30549.
    CleanExiMM_TACR2.
    GenevestigatoriP30549.

    Interactioni

    Structurei

    3D structure databases

    ProteinModelPortaliP30549.
    SMRiP30549. Positions 9-341.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 3232ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini57 – 6913CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini91 – 10717ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini130 – 14920CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini171 – 19626ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini219 – 25133CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini273 – 29018ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini311 – 38474CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei33 – 5624Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei70 – 9021Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei108 – 12922Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei150 – 17021Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei197 – 21822Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei252 – 27221Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei291 – 31020Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG331485.
    HOGENOMiHOG000013018.
    HOVERGENiHBG103412.
    InParanoidiP30549.
    KOiK04223.
    OMAiLCMAAFN.
    OrthoDBiEOG7N37FW.
    PhylomeDBiP30549.
    TreeFamiTF315303.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR001681. Neurokn_rcpt.
    IPR000913. NK2_rcpt.
    [Graphical view]
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR01025. NEUROKININ2R.
    PR00244. NEUROKININR.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P30549-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGAHASVTDT NILSGLESNA TGVTAFSMPG WQLALWATAY LALVLVAVTG    50
    NATVIWIILA HERMRTVTNY FIINLALADL CMAAFNATFN FIYASHNIWY 100
    FGSTFCYFQN LFPVTAMFVS IYSMTAIAAD RYMAIVHPFQ PRLSAPSTKA 150
    VIAVIWLVAL ALASPQCFYS TITVDQGATK CVVAWPNDNG GKMLLLYHLV 200
    VFVLIYFLPL VVMFAAYSVI GLTLWKRAVP RHQAHGANLR HLQAKKKFVK 250
    AMVLVVVTFA ICWLPYHLYF ILGTFQEDIY YRKFIQQVYL ALFWLAMSST 300
    MYNPIIYCCL NHRFRSGFRL AFRCCPWGTP TEEDRLELTH TPSISRRVNR 350
    CHTKETLFMT GDMTHSEATN GQVGGPQDGE PAGP 384
    Length:384
    Mass (Da):43,114
    Last modified:April 1, 1993 - v1
    Checksum:i7937F05A2BB90759
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X62933 mRNA. Translation: CAA44706.1.
    CCDSiCCDS35919.1.
    PIRiS20303.
    RefSeqiNP_033340.3. NM_009314.4.
    UniGeneiMm.8054.

    Genome annotation databases

    EnsembliENSMUST00000020278; ENSMUSP00000020278; ENSMUSG00000020081.
    GeneIDi21337.
    KEGGimmu:21337.
    UCSCiuc007fgx.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X62933 mRNA. Translation: CAA44706.1 .
    CCDSi CCDS35919.1.
    PIRi S20303.
    RefSeqi NP_033340.3. NM_009314.4.
    UniGenei Mm.8054.

    3D structure databases

    ProteinModelPortali P30549.
    SMRi P30549. Positions 9-341.
    ModBasei Search...
    MobiDBi Search...

    Chemistry

    BindingDBi P30549.
    ChEMBLi CHEMBL2813.
    GuidetoPHARMACOLOGYi 361.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei P30549.

    Proteomic databases

    PRIDEi P30549.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000020278 ; ENSMUSP00000020278 ; ENSMUSG00000020081 .
    GeneIDi 21337.
    KEGGi mmu:21337.
    UCSCi uc007fgx.2. mouse.

    Organism-specific databases

    CTDi 6865.
    MGIi MGI:98477. Tacr2.

    Phylogenomic databases

    eggNOGi NOG331485.
    HOGENOMi HOG000013018.
    HOVERGENi HBG103412.
    InParanoidi P30549.
    KOi K04223.
    OMAi LCMAAFN.
    OrthoDBi EOG7N37FW.
    PhylomeDBi P30549.
    TreeFami TF315303.

    Enzyme and pathway databases

    Reactomei REACT_207651. G alpha (q) signalling events.

    Miscellaneous databases

    NextBioi 300504.
    PROi P30549.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P30549.
    Bgeei P30549.
    CleanExi MM_TACR2.
    Genevestigatori P30549.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR001681. Neurokn_rcpt.
    IPR000913. NK2_rcpt.
    [Graphical view ]
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR01025. NEUROKININ2R.
    PR00244. NEUROKININR.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning of the murine substance K and substance P receptor genes."
      Sundelin J.B., Provvedini D.M., Wahlestedt C.R., Laurell H., Pohl J.S., Peterson P.A.
      Eur. J. Biochem. 203:625-631(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Intestine.

    Entry informationi

    Entry nameiNK2R_MOUSE
    AccessioniPrimary (citable) accession number: P30549
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 1, 1993
    Last sequence update: April 1, 1993
    Last modified: October 1, 2014
    This is version 119 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3