Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P30549 (NK2R_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 117. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Substance-K receptor

Short name=SKR
Alternative name(s):
NK-2 receptor
Short name=NK-2R
Neurokinin A receptor
Tachykinin receptor 2
Gene names
Name:Tacr2
Synonyms:Tac2r
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length384 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

This is a receptor for the tachykinin neuropeptide substance K (neurokinin A). It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: substance K > neuromedin-K > substance P.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 384384Substance-K receptor
PRO_0000069895

Regions

Topological domain1 – 3232Extracellular Potential
Transmembrane33 – 5624Helical; Name=1; Potential
Topological domain57 – 6913Cytoplasmic Potential
Transmembrane70 – 9021Helical; Name=2; Potential
Topological domain91 – 10717Extracellular Potential
Transmembrane108 – 12922Helical; Name=3; Potential
Topological domain130 – 14920Cytoplasmic Potential
Transmembrane150 – 17021Helical; Name=4; Potential
Topological domain171 – 19626Extracellular Potential
Transmembrane197 – 21822Helical; Name=5; Potential
Topological domain219 – 25133Cytoplasmic Potential
Transmembrane252 – 27221Helical; Name=6; Potential
Topological domain273 – 29018Extracellular Potential
Transmembrane291 – 31020Helical; Name=7; Potential
Topological domain311 – 38474Cytoplasmic Potential

Amino acid modifications

Lipidation3241S-palmitoyl cysteine Potential
Glycosylation191N-linked (GlcNAc...) Potential
Disulfide bond106 ↔ 181 By similarity

Sequences

Sequence LengthMass (Da)Tools
P30549 [UniParc].

Last modified April 1, 1993. Version 1.
Checksum: 7937F05A2BB90759

FASTA38443,114
        10         20         30         40         50         60 
MGAHASVTDT NILSGLESNA TGVTAFSMPG WQLALWATAY LALVLVAVTG NATVIWIILA 

        70         80         90        100        110        120 
HERMRTVTNY FIINLALADL CMAAFNATFN FIYASHNIWY FGSTFCYFQN LFPVTAMFVS 

       130        140        150        160        170        180 
IYSMTAIAAD RYMAIVHPFQ PRLSAPSTKA VIAVIWLVAL ALASPQCFYS TITVDQGATK 

       190        200        210        220        230        240 
CVVAWPNDNG GKMLLLYHLV VFVLIYFLPL VVMFAAYSVI GLTLWKRAVP RHQAHGANLR 

       250        260        270        280        290        300 
HLQAKKKFVK AMVLVVVTFA ICWLPYHLYF ILGTFQEDIY YRKFIQQVYL ALFWLAMSST 

       310        320        330        340        350        360 
MYNPIIYCCL NHRFRSGFRL AFRCCPWGTP TEEDRLELTH TPSISRRVNR CHTKETLFMT 

       370        380 
GDMTHSEATN GQVGGPQDGE PAGP 

« Hide

References

[1]"Molecular cloning of the murine substance K and substance P receptor genes."
Sundelin J.B., Provvedini D.M., Wahlestedt C.R., Laurell H., Pohl J.S., Peterson P.A.
Eur. J. Biochem. 203:625-631(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Intestine.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X62933 mRNA. Translation: CAA44706.1.
CCDSCCDS35919.1.
PIRS20303.
RefSeqNP_033340.3. NM_009314.4.
UniGeneMm.8054.

3D structure databases

ProteinModelPortalP30549.
SMRP30549. Positions 9-341.
ModBaseSearch...
MobiDBSearch...

Chemistry

BindingDBP30549.
ChEMBLCHEMBL2813.
GuidetoPHARMACOLOGY361.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteP30549.

Proteomic databases

PRIDEP30549.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000020278; ENSMUSP00000020278; ENSMUSG00000020081.
GeneID21337.
KEGGmmu:21337.
UCSCuc007fgx.2. mouse.

Organism-specific databases

CTD6865.
MGIMGI:98477. Tacr2.

Phylogenomic databases

eggNOGNOG331485.
HOGENOMHOG000013018.
HOVERGENHBG103412.
InParanoidP30549.
KOK04223.
OMALCMAAFN.
OrthoDBEOG7N37FW.
PhylomeDBP30549.
TreeFamTF315303.

Gene expression databases

ArrayExpressP30549.
BgeeP30549.
CleanExMM_TACR2.
GenevestigatorP30549.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001681. Neurokn_rcpt.
IPR000913. NK2_rcpt.
[Graphical view]
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR01025. NEUROKININ2R.
PR00244. NEUROKININR.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio300504.
PROP30549.
SOURCESearch...

Entry information

Entry nameNK2R_MOUSE
AccessionPrimary (citable) accession number: P30549
Entry history
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: July 9, 2014
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries