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Protein

Substance-P receptor

Gene

Tacr1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

This is a receptor for the tachykinin neuropeptide substance P. It is probably associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: substance P > substance K > neuromedin K.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-MMU-380095. Tachykinin receptors bind tachykinins.
R-MMU-416476. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Substance-P receptor
Short name:
SPR
Alternative name(s):
NK-1 receptor
Short name:
NK-1R
Tachykinin receptor 1
Gene namesi
Name:Tacr1
Synonyms:Tac1r
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:98475. Tacr1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 31ExtracellularSequence analysisAdd BLAST31
Transmembranei32 – 54Helical; Name=1Sequence analysisAdd BLAST23
Topological domaini55 – 64CytoplasmicSequence analysis10
Transmembranei65 – 86Helical; Name=2Sequence analysisAdd BLAST22
Topological domaini87 – 106ExtracellularSequence analysisAdd BLAST20
Transmembranei107 – 128Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini129 – 148CytoplasmicSequence analysisAdd BLAST20
Transmembranei149 – 169Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini170 – 194ExtracellularSequence analysisAdd BLAST25
Transmembranei195 – 219Helical; Name=5Sequence analysisAdd BLAST25
Topological domaini220 – 248CytoplasmicSequence analysisAdd BLAST29
Transmembranei249 – 270Helical; Name=6Sequence analysisAdd BLAST22
Topological domaini271 – 283ExtracellularSequence analysisAdd BLAST13
Transmembranei284 – 308Helical; Name=7Sequence analysisAdd BLAST25
Topological domaini309 – 407CytoplasmicSequence analysisAdd BLAST99

GO - Cellular componenti

  • cell periphery Source: MGI
  • integral component of plasma membrane Source: GO_Central
  • plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL2668.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000698871 – 407Substance-P receptorAdd BLAST407

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi14N-linked (GlcNAc...)Sequence analysis1
Glycosylationi18N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi105 ↔ 180PROSITE-ProRule annotation
Lipidationi322S-palmitoyl cysteineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

MaxQBiP30548.
PaxDbiP30548.
PRIDEiP30548.

PTM databases

PhosphoSitePlusiP30548.
SwissPalmiP30548.

Expressioni

Gene expression databases

BgeeiENSMUSG00000030043.
CleanExiMM_TACR1.
GenevisibleiP30548. MM.

Interactioni

Subunit structurei

Interacts with ARRB1.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000032122.

Chemistry databases

BindingDBiP30548.

Structurei

3D structure databases

ProteinModelPortaliP30548.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4219. Eukaryota.
ENOG410XSC5. LUCA.
GeneTreeiENSGT00760000118781.
HOGENOMiHOG000013018.
HOVERGENiHBG103412.
InParanoidiP30548.
KOiK04222.
OMAiMIIVVCT.
OrthoDBiEOG091G0WYG.
TreeFamiTF315303.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001681. Neurokn_rcpt.
IPR000046. NK1_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01024. NEUROKININ1R.
PR00244. NEUROKININR.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P30548-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDNVLPVDSD LFPNTSTNTS ESNQFVQPTW QIVLWAAAYT VIVVTSVVGN
60 70 80 90 100
VVVIWIILAH KRMRTVTNYF LVNLAFAEAC MAAFNTVVNF TYAVHNVWYY
110 120 130 140 150
GLFYCKFHNF FPIAALFASI YSMTAVAFDR YMAIIHPLQP RLSATATKVV
160 170 180 190 200
IFVIWVLALL LAFPQGYYST TETMPSRVVC MIEWPEHPNR TYEKAYHICV
210 220 230 240 250
TVLIYFLPLL VIGYAYTVVG ITLWASEIPG DSSDRYHEQV SAKRKVVKMM
260 270 280 290 300
IVVVCTFAIC WLPFHIFFLL PYINPDLYLK KFIQQVYLAS MWLAMSSTMY
310 320 330 340 350
NPIIYCCLND RFRLGFKHAF RCCPFISAGD YEGLEMKSTR YLQTQSSVYK
360 370 380 390 400
VSRLETTIST VVGAHEDEPE EGPKATPSSL DLTSNGSSRS NSKTMTESSS

FYSNMLA
Length:407
Mass (Da):46,322
Last modified:July 27, 2011 - v2
Checksum:i451B6B875A6659A0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti405M → I in CAA44707 (PubMed:1370937).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X62934 mRNA. Translation: CAA44707.1.
AK038558 mRNA. Translation: BAC30042.1.
CH466523 Genomic DNA. Translation: EDK99033.1.
BC075631 mRNA. Translation: AAH75631.1.
BC098332 mRNA. Translation: AAH98332.1.
L27828 mRNA. Translation: AAA17892.1.
L27826 mRNA. Translation: AAA17891.1.
CCDSiCCDS20262.1.
PIRiS20304.
RefSeqiNP_033339.2. NM_009313.5.
XP_006505926.1. XM_006505863.3.
XP_006505927.1. XM_006505864.3.
XP_006505928.1. XM_006505865.3.
UniGeneiMm.8055.

Genome annotation databases

EnsembliENSMUST00000032122; ENSMUSP00000032122; ENSMUSG00000030043.
ENSMUST00000203775; ENSMUSP00000145217; ENSMUSG00000030043.
GeneIDi21336.
KEGGimmu:21336.
UCSCiuc009clh.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X62934 mRNA. Translation: CAA44707.1.
AK038558 mRNA. Translation: BAC30042.1.
CH466523 Genomic DNA. Translation: EDK99033.1.
BC075631 mRNA. Translation: AAH75631.1.
BC098332 mRNA. Translation: AAH98332.1.
L27828 mRNA. Translation: AAA17892.1.
L27826 mRNA. Translation: AAA17891.1.
CCDSiCCDS20262.1.
PIRiS20304.
RefSeqiNP_033339.2. NM_009313.5.
XP_006505926.1. XM_006505863.3.
XP_006505927.1. XM_006505864.3.
XP_006505928.1. XM_006505865.3.
UniGeneiMm.8055.

3D structure databases

ProteinModelPortaliP30548.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000032122.

Chemistry databases

BindingDBiP30548.
ChEMBLiCHEMBL2668.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSitePlusiP30548.
SwissPalmiP30548.

Proteomic databases

MaxQBiP30548.
PaxDbiP30548.
PRIDEiP30548.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000032122; ENSMUSP00000032122; ENSMUSG00000030043.
ENSMUST00000203775; ENSMUSP00000145217; ENSMUSG00000030043.
GeneIDi21336.
KEGGimmu:21336.
UCSCiuc009clh.2. mouse.

Organism-specific databases

CTDi6869.
MGIiMGI:98475. Tacr1.

Phylogenomic databases

eggNOGiKOG4219. Eukaryota.
ENOG410XSC5. LUCA.
GeneTreeiENSGT00760000118781.
HOGENOMiHOG000013018.
HOVERGENiHBG103412.
InParanoidiP30548.
KOiK04222.
OMAiMIIVVCT.
OrthoDBiEOG091G0WYG.
TreeFamiTF315303.

Enzyme and pathway databases

ReactomeiR-MMU-380095. Tachykinin receptors bind tachykinins.
R-MMU-416476. G alpha (q) signalling events.

Miscellaneous databases

PROiP30548.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000030043.
CleanExiMM_TACR1.
GenevisibleiP30548. MM.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001681. Neurokn_rcpt.
IPR000046. NK1_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01024. NEUROKININ1R.
PR00244. NEUROKININR.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNK1R_MOUSE
AccessioniPrimary (citable) accession number: P30548
Secondary accession number(s): Q8BYR7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: July 27, 2011
Last modified: November 2, 2016
This is version 130 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.