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P30548

- NK1R_MOUSE

UniProt

P30548 - NK1R_MOUSE

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Protein

Substance-P receptor

Gene

Tacr1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

This is a receptor for the tachykinin neuropeptide substance P. It is probably associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: substance P > substance K > neuromedin K.

GO - Molecular functioni

  1. substance P receptor activity Source: Ensembl

GO - Biological processi

  1. acute inflammatory response Source: Ensembl
  2. aggressive behavior Source: Ensembl
  3. angiotensin-mediated drinking behavior Source: Ensembl
  4. associative learning Source: Ensembl
  5. behavioral response to pain Source: Ensembl
  6. eating behavior Source: Ensembl
  7. long-term memory Source: Ensembl
  8. operant conditioning Source: Ensembl
  9. positive regulation of action potential Source: Ensembl
  10. positive regulation of blood pressure Source: Ensembl
  11. positive regulation of cytosolic calcium ion concentration Source: Ensembl
  12. positive regulation of epithelial cell migration Source: Ensembl
  13. positive regulation of epithelial cell proliferation Source: Ensembl
  14. positive regulation of hormone secretion Source: Ensembl
  15. positive regulation of leukocyte migration Source: Ensembl
  16. positive regulation of lymphocyte proliferation Source: Ensembl
  17. positive regulation of ossification Source: Ensembl
  18. positive regulation of renal sodium excretion Source: Ensembl
  19. positive regulation of saliva secretion Source: Ensembl
  20. positive regulation of stress fiber assembly Source: Ensembl
  21. positive regulation of synaptic transmission, cholinergic Source: Ensembl
  22. positive regulation of synaptic transmission, GABAergic Source: Ensembl
  23. positive regulation of uterine smooth muscle contraction Source: Ensembl
  24. positive regulation of vascular permeability Source: Ensembl
  25. positive regulation of vasoconstriction Source: Ensembl
  26. regulation of smooth muscle cell migration Source: Ensembl
  27. regulation of smooth muscle cell proliferation Source: Ensembl
  28. response to auditory stimulus Source: Ensembl
  29. response to estradiol Source: Ensembl
  30. response to ethanol Source: Ensembl
  31. response to heat Source: Ensembl
  32. response to morphine Source: Ensembl
  33. response to nicotine Source: Ensembl
  34. response to ozone Source: Ensembl
  35. response to pain Source: MGI
  36. response to progesterone Source: Ensembl
  37. smooth muscle contraction involved in micturition Source: Ensembl
  38. sperm ejaculation Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_207651. G alpha (q) signalling events.
REACT_252339. Tachykinin receptors bind tachykinins.

Names & Taxonomyi

Protein namesi
Recommended name:
Substance-P receptor
Short name:
SPR
Alternative name(s):
NK-1 receptor
Short name:
NK-1R
Tachykinin receptor 1
Gene namesi
Name:Tacr1
Synonyms:Tac1r
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 6

Organism-specific databases

MGIiMGI:98475. Tacr1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3131ExtracellularSequence AnalysisAdd
BLAST
Transmembranei32 – 5423Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini55 – 6410CytoplasmicSequence Analysis
Transmembranei65 – 8622Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini87 – 10620ExtracellularSequence AnalysisAdd
BLAST
Transmembranei107 – 12822Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini129 – 14820CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei149 – 16921Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini170 – 19425ExtracellularSequence AnalysisAdd
BLAST
Transmembranei195 – 21925Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini220 – 24829CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei249 – 27022Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini271 – 28313ExtracellularSequence AnalysisAdd
BLAST
Transmembranei284 – 30825Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini309 – 40799CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. cell body Source: Ensembl
  2. cell periphery Source: MGI
  3. cell surface Source: Ensembl
  4. cytoplasm Source: Ensembl
  5. dendrite Source: Ensembl
  6. integral component of membrane Source: UniProtKB-KW
  7. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 407407Substance-P receptorPRO_0000069887Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi14 – 141N-linked (GlcNAc...)Sequence Analysis
Glycosylationi18 – 181N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi105 ↔ 180PROSITE-ProRule annotation
Lipidationi322 – 3221S-palmitoyl cysteineSequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

MaxQBiP30548.

PTM databases

PhosphoSiteiP30548.

Expressioni

Gene expression databases

BgeeiP30548.
CleanExiMM_TACR1.
ExpressionAtlasiP30548. baseline.
GenevestigatoriP30548.

Interactioni

Subunit structurei

Interacts with ARRB1.By similarity

Structurei

3D structure databases

ProteinModelPortaliP30548.
SMRiP30548. Positions 2-364.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG331485.
GeneTreeiENSGT00760000118781.
HOGENOMiHOG000013018.
HOVERGENiHBG103412.
InParanoidiP30548.
KOiK04222.
OMAiMIIVVCT.
OrthoDBiEOG7N37FW.
TreeFamiTF315303.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001681. Neurokn_rcpt.
IPR000046. NK1_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01024. NEUROKININ1R.
PR00244. NEUROKININR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P30548-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDNVLPVDSD LFPNTSTNTS ESNQFVQPTW QIVLWAAAYT VIVVTSVVGN
60 70 80 90 100
VVVIWIILAH KRMRTVTNYF LVNLAFAEAC MAAFNTVVNF TYAVHNVWYY
110 120 130 140 150
GLFYCKFHNF FPIAALFASI YSMTAVAFDR YMAIIHPLQP RLSATATKVV
160 170 180 190 200
IFVIWVLALL LAFPQGYYST TETMPSRVVC MIEWPEHPNR TYEKAYHICV
210 220 230 240 250
TVLIYFLPLL VIGYAYTVVG ITLWASEIPG DSSDRYHEQV SAKRKVVKMM
260 270 280 290 300
IVVVCTFAIC WLPFHIFFLL PYINPDLYLK KFIQQVYLAS MWLAMSSTMY
310 320 330 340 350
NPIIYCCLND RFRLGFKHAF RCCPFISAGD YEGLEMKSTR YLQTQSSVYK
360 370 380 390 400
VSRLETTIST VVGAHEDEPE EGPKATPSSL DLTSNGSSRS NSKTMTESSS

FYSNMLA
Length:407
Mass (Da):46,322
Last modified:July 27, 2011 - v2
Checksum:i451B6B875A6659A0
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti405 – 4051M → I in CAA44707. (PubMed:1370937)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X62934 mRNA. Translation: CAA44707.1.
AK038558 mRNA. Translation: BAC30042.1.
CH466523 Genomic DNA. Translation: EDK99033.1.
BC075631 mRNA. Translation: AAH75631.1.
BC098332 mRNA. Translation: AAH98332.1.
L27828 mRNA. Translation: AAA17892.1.
L27826 mRNA. Translation: AAA17891.1.
CCDSiCCDS20262.1.
PIRiS20304.
RefSeqiNP_033339.2. NM_009313.5.
XP_006505926.1. XM_006505863.1.
XP_006505927.1. XM_006505864.1.
XP_006505928.1. XM_006505865.1.
UniGeneiMm.8055.

Genome annotation databases

EnsembliENSMUST00000032122; ENSMUSP00000032122; ENSMUSG00000030043.
GeneIDi21336.
KEGGimmu:21336.
UCSCiuc009clh.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X62934 mRNA. Translation: CAA44707.1 .
AK038558 mRNA. Translation: BAC30042.1 .
CH466523 Genomic DNA. Translation: EDK99033.1 .
BC075631 mRNA. Translation: AAH75631.1 .
BC098332 mRNA. Translation: AAH98332.1 .
L27828 mRNA. Translation: AAA17892.1 .
L27826 mRNA. Translation: AAA17891.1 .
CCDSi CCDS20262.1.
PIRi S20304.
RefSeqi NP_033339.2. NM_009313.5.
XP_006505926.1. XM_006505863.1.
XP_006505927.1. XM_006505864.1.
XP_006505928.1. XM_006505865.1.
UniGenei Mm.8055.

3D structure databases

ProteinModelPortali P30548.
SMRi P30548. Positions 2-364.
ModBasei Search...
MobiDBi Search...

Chemistry

ChEMBLi CHEMBL2668.
GuidetoPHARMACOLOGYi 360.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei P30548.

Proteomic databases

MaxQBi P30548.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000032122 ; ENSMUSP00000032122 ; ENSMUSG00000030043 .
GeneIDi 21336.
KEGGi mmu:21336.
UCSCi uc009clh.2. mouse.

Organism-specific databases

CTDi 6869.
MGIi MGI:98475. Tacr1.

Phylogenomic databases

eggNOGi NOG331485.
GeneTreei ENSGT00760000118781.
HOGENOMi HOG000013018.
HOVERGENi HBG103412.
InParanoidi P30548.
KOi K04222.
OMAi MIIVVCT.
OrthoDBi EOG7N37FW.
TreeFami TF315303.

Enzyme and pathway databases

Reactomei REACT_207651. G alpha (q) signalling events.
REACT_252339. Tachykinin receptors bind tachykinins.

Miscellaneous databases

NextBioi 300500.
PROi P30548.
SOURCEi Search...

Gene expression databases

Bgeei P30548.
CleanExi MM_TACR1.
ExpressionAtlasi P30548. baseline.
Genevestigatori P30548.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001681. Neurokn_rcpt.
IPR000046. NK1_rcpt.
[Graphical view ]
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR01024. NEUROKININ1R.
PR00244. NEUROKININR.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning of the murine substance K and substance P receptor genes."
    Sundelin J.B., Provvedini D.M., Wahlestedt C.R., Laurell H., Pohl J.S., Peterson P.A.
    Eur. J. Biochem. 203:625-631(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Intestine.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Hypothalamus.
  3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Brain.
  5. "Molecular evidence that granuloma T lymphocytes in murine schistosomiasis mansoni express an authentic substance P (NK-1) receptor."
    Cook G.A., Elliott D., Metwali A., Blum A.M., Sandor M., Lynch R., Weinstock J.V.
    J. Immunol. 152:1830-1835(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 63-290.
    Strain: CBA.
    Tissue: Brain and T-cell.

Entry informationi

Entry nameiNK1R_MOUSE
AccessioniPrimary (citable) accession number: P30548
Secondary accession number(s): Q8BYR7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: July 27, 2011
Last modified: November 26, 2014
This is version 112 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3