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Protein

Substance-P receptor

Gene

Tacr1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

This is a receptor for the tachykinin neuropeptide substance P. It is probably associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: substance P > substance K > neuromedin K.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_277687. Tachykinin receptors bind tachykinins.
REACT_347934. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Substance-P receptor
Short name:
SPR
Alternative name(s):
NK-1 receptor
Short name:
NK-1R
Tachykinin receptor 1
Gene namesi
Name:Tacr1
Synonyms:Tac1r
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:98475. Tacr1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3131ExtracellularSequence AnalysisAdd
BLAST
Transmembranei32 – 5423Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini55 – 6410CytoplasmicSequence Analysis
Transmembranei65 – 8622Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini87 – 10620ExtracellularSequence AnalysisAdd
BLAST
Transmembranei107 – 12822Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini129 – 14820CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei149 – 16921Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini170 – 19425ExtracellularSequence AnalysisAdd
BLAST
Transmembranei195 – 21925Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini220 – 24829CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei249 – 27022Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini271 – 28313ExtracellularSequence AnalysisAdd
BLAST
Transmembranei284 – 30825Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini309 – 40799CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 407407Substance-P receptorPRO_0000069887Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi14 – 141N-linked (GlcNAc...)Sequence Analysis
Glycosylationi18 – 181N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi105 ↔ 180PROSITE-ProRule annotation
Lipidationi322 – 3221S-palmitoyl cysteineSequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

MaxQBiP30548.

PTM databases

PhosphoSiteiP30548.

Expressioni

Gene expression databases

BgeeiP30548.
CleanExiMM_TACR1.
ExpressionAtlasiP30548. baseline.
GenevisibleiP30548. MM.

Interactioni

Subunit structurei

Interacts with ARRB1.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000032122.

Structurei

3D structure databases

ProteinModelPortaliP30548.
SMRiP30548. Positions 2-364.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG331485.
GeneTreeiENSGT00760000118781.
HOGENOMiHOG000013018.
HOVERGENiHBG103412.
InParanoidiP30548.
KOiK04222.
OMAiMIIVVCT.
OrthoDBiEOG7N37FW.
TreeFamiTF315303.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001681. Neurokn_rcpt.
IPR000046. NK1_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01024. NEUROKININ1R.
PR00244. NEUROKININR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P30548-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDNVLPVDSD LFPNTSTNTS ESNQFVQPTW QIVLWAAAYT VIVVTSVVGN
60 70 80 90 100
VVVIWIILAH KRMRTVTNYF LVNLAFAEAC MAAFNTVVNF TYAVHNVWYY
110 120 130 140 150
GLFYCKFHNF FPIAALFASI YSMTAVAFDR YMAIIHPLQP RLSATATKVV
160 170 180 190 200
IFVIWVLALL LAFPQGYYST TETMPSRVVC MIEWPEHPNR TYEKAYHICV
210 220 230 240 250
TVLIYFLPLL VIGYAYTVVG ITLWASEIPG DSSDRYHEQV SAKRKVVKMM
260 270 280 290 300
IVVVCTFAIC WLPFHIFFLL PYINPDLYLK KFIQQVYLAS MWLAMSSTMY
310 320 330 340 350
NPIIYCCLND RFRLGFKHAF RCCPFISAGD YEGLEMKSTR YLQTQSSVYK
360 370 380 390 400
VSRLETTIST VVGAHEDEPE EGPKATPSSL DLTSNGSSRS NSKTMTESSS

FYSNMLA
Length:407
Mass (Da):46,322
Last modified:July 27, 2011 - v2
Checksum:i451B6B875A6659A0
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti405 – 4051M → I in CAA44707 (PubMed:1370937).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X62934 mRNA. Translation: CAA44707.1.
AK038558 mRNA. Translation: BAC30042.1.
CH466523 Genomic DNA. Translation: EDK99033.1.
BC075631 mRNA. Translation: AAH75631.1.
BC098332 mRNA. Translation: AAH98332.1.
L27828 mRNA. Translation: AAA17892.1.
L27826 mRNA. Translation: AAA17891.1.
CCDSiCCDS20262.1.
PIRiS20304.
RefSeqiNP_033339.2. NM_009313.5.
XP_006505926.1. XM_006505863.2.
XP_006505927.1. XM_006505864.2.
XP_006505928.1. XM_006505865.2.
XP_011239580.1. XM_011241278.1.
UniGeneiMm.8055.

Genome annotation databases

EnsembliENSMUST00000032122; ENSMUSP00000032122; ENSMUSG00000030043.
GeneIDi21336.
KEGGimmu:21336.
UCSCiuc009clh.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X62934 mRNA. Translation: CAA44707.1.
AK038558 mRNA. Translation: BAC30042.1.
CH466523 Genomic DNA. Translation: EDK99033.1.
BC075631 mRNA. Translation: AAH75631.1.
BC098332 mRNA. Translation: AAH98332.1.
L27828 mRNA. Translation: AAA17892.1.
L27826 mRNA. Translation: AAA17891.1.
CCDSiCCDS20262.1.
PIRiS20304.
RefSeqiNP_033339.2. NM_009313.5.
XP_006505926.1. XM_006505863.2.
XP_006505927.1. XM_006505864.2.
XP_006505928.1. XM_006505865.2.
XP_011239580.1. XM_011241278.1.
UniGeneiMm.8055.

3D structure databases

ProteinModelPortaliP30548.
SMRiP30548. Positions 2-364.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000032122.

Chemistry

BindingDBiP30548.
ChEMBLiCHEMBL2668.
GuidetoPHARMACOLOGYi360.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiP30548.

Proteomic databases

MaxQBiP30548.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000032122; ENSMUSP00000032122; ENSMUSG00000030043.
GeneIDi21336.
KEGGimmu:21336.
UCSCiuc009clh.2. mouse.

Organism-specific databases

CTDi6869.
MGIiMGI:98475. Tacr1.

Phylogenomic databases

eggNOGiNOG331485.
GeneTreeiENSGT00760000118781.
HOGENOMiHOG000013018.
HOVERGENiHBG103412.
InParanoidiP30548.
KOiK04222.
OMAiMIIVVCT.
OrthoDBiEOG7N37FW.
TreeFamiTF315303.

Enzyme and pathway databases

ReactomeiREACT_277687. Tachykinin receptors bind tachykinins.
REACT_347934. G alpha (q) signalling events.

Miscellaneous databases

NextBioi300500.
PROiP30548.
SOURCEiSearch...

Gene expression databases

BgeeiP30548.
CleanExiMM_TACR1.
ExpressionAtlasiP30548. baseline.
GenevisibleiP30548. MM.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001681. Neurokn_rcpt.
IPR000046. NK1_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01024. NEUROKININ1R.
PR00244. NEUROKININR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning of the murine substance K and substance P receptor genes."
    Sundelin J.B., Provvedini D.M., Wahlestedt C.R., Laurell H., Pohl J.S., Peterson P.A.
    Eur. J. Biochem. 203:625-631(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Intestine.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Hypothalamus.
  3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Brain.
  5. "Molecular evidence that granuloma T lymphocytes in murine schistosomiasis mansoni express an authentic substance P (NK-1) receptor."
    Cook G.A., Elliott D., Metwali A., Blum A.M., Sandor M., Lynch R., Weinstock J.V.
    J. Immunol. 152:1830-1835(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 63-290.
    Strain: CBA.
    Tissue: Brain and T-cell.

Entry informationi

Entry nameiNK1R_MOUSE
AccessioniPrimary (citable) accession number: P30548
Secondary accession number(s): Q8BYR7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: July 27, 2011
Last modified: July 22, 2015
This is version 119 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.