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P30548

- NK1R_MOUSE

UniProt

P30548 - NK1R_MOUSE

Protein

Substance-P receptor

Gene

Tacr1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 110 (01 Oct 2014)
      Sequence version 2 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    This is a receptor for the tachykinin neuropeptide substance P. It is probably associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: substance P > substance K > neuromedin K.

    GO - Molecular functioni

    1. substance P receptor activity Source: Ensembl

    GO - Biological processi

    1. acute inflammatory response Source: Ensembl
    2. aggressive behavior Source: Ensembl
    3. angiotensin-mediated drinking behavior Source: Ensembl
    4. associative learning Source: Ensembl
    5. behavioral response to pain Source: Ensembl
    6. eating behavior Source: Ensembl
    7. long-term memory Source: Ensembl
    8. operant conditioning Source: Ensembl
    9. positive regulation of action potential Source: Ensembl
    10. positive regulation of blood pressure Source: Ensembl
    11. positive regulation of cytosolic calcium ion concentration Source: Ensembl
    12. positive regulation of epithelial cell migration Source: Ensembl
    13. positive regulation of epithelial cell proliferation Source: Ensembl
    14. positive regulation of hormone secretion Source: Ensembl
    15. positive regulation of leukocyte migration Source: Ensembl
    16. positive regulation of lymphocyte proliferation Source: Ensembl
    17. positive regulation of ossification Source: Ensembl
    18. positive regulation of renal sodium excretion Source: Ensembl
    19. positive regulation of saliva secretion Source: Ensembl
    20. positive regulation of stress fiber assembly Source: Ensembl
    21. positive regulation of synaptic transmission, cholinergic Source: Ensembl
    22. positive regulation of synaptic transmission, GABAergic Source: Ensembl
    23. positive regulation of uterine smooth muscle contraction Source: Ensembl
    24. positive regulation of vascular permeability Source: Ensembl
    25. positive regulation of vasoconstriction Source: Ensembl
    26. regulation of smooth muscle cell migration Source: Ensembl
    27. regulation of smooth muscle cell proliferation Source: Ensembl
    28. response to auditory stimulus Source: Ensembl
    29. response to estradiol Source: Ensembl
    30. response to ethanol Source: Ensembl
    31. response to heat Source: Ensembl
    32. response to morphine Source: Ensembl
    33. response to nicotine Source: Ensembl
    34. response to ozone Source: Ensembl
    35. response to pain Source: MGI
    36. response to progesterone Source: Ensembl
    37. smooth muscle contraction involved in micturition Source: Ensembl
    38. sperm ejaculation Source: Ensembl

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Enzyme and pathway databases

    ReactomeiREACT_207651. G alpha (q) signalling events.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Substance-P receptor
    Short name:
    SPR
    Alternative name(s):
    NK-1 receptor
    Short name:
    NK-1R
    Tachykinin receptor 1
    Gene namesi
    Name:Tacr1
    Synonyms:Tac1r
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 6

    Organism-specific databases

    MGIiMGI:98475. Tacr1.

    Subcellular locationi

    GO - Cellular componenti

    1. cell body Source: Ensembl
    2. cell periphery Source: MGI
    3. cell surface Source: Ensembl
    4. cytoplasm Source: Ensembl
    5. dendrite Source: Ensembl
    6. integral component of membrane Source: UniProtKB-KW
    7. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 407407Substance-P receptorPRO_0000069887Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi14 – 141N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi18 – 181N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi105 ↔ 180PROSITE-ProRule annotation
    Lipidationi322 – 3221S-palmitoyl cysteineSequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

    PTM databases

    PhosphoSiteiP30548.

    Expressioni

    Gene expression databases

    ArrayExpressiP30548.
    BgeeiP30548.
    CleanExiMM_TACR1.
    GenevestigatoriP30548.

    Interactioni

    Subunit structurei

    Interacts with ARRB1.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliP30548.
    SMRiP30548. Positions 2-364.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 3131ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini55 – 6410CytoplasmicSequence Analysis
    Topological domaini87 – 10620ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini129 – 14820CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini170 – 19425ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini220 – 24829CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini271 – 28313ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini309 – 40799CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei32 – 5423Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei65 – 8622Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei107 – 12822Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei149 – 16921Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei195 – 21925Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei249 – 27022Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei284 – 30825Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG331485.
    GeneTreeiENSGT00710000106471.
    HOGENOMiHOG000013018.
    HOVERGENiHBG103412.
    InParanoidiQ8BYR7.
    KOiK04222.
    OMAiMIIVVCT.
    OrthoDBiEOG7N37FW.
    TreeFamiTF315303.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR001681. Neurokn_rcpt.
    IPR000046. NK1_rcpt.
    [Graphical view]
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR01024. NEUROKININ1R.
    PR00244. NEUROKININR.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P30548-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDNVLPVDSD LFPNTSTNTS ESNQFVQPTW QIVLWAAAYT VIVVTSVVGN    50
    VVVIWIILAH KRMRTVTNYF LVNLAFAEAC MAAFNTVVNF TYAVHNVWYY 100
    GLFYCKFHNF FPIAALFASI YSMTAVAFDR YMAIIHPLQP RLSATATKVV 150
    IFVIWVLALL LAFPQGYYST TETMPSRVVC MIEWPEHPNR TYEKAYHICV 200
    TVLIYFLPLL VIGYAYTVVG ITLWASEIPG DSSDRYHEQV SAKRKVVKMM 250
    IVVVCTFAIC WLPFHIFFLL PYINPDLYLK KFIQQVYLAS MWLAMSSTMY 300
    NPIIYCCLND RFRLGFKHAF RCCPFISAGD YEGLEMKSTR YLQTQSSVYK 350
    VSRLETTIST VVGAHEDEPE EGPKATPSSL DLTSNGSSRS NSKTMTESSS 400
    FYSNMLA 407
    Length:407
    Mass (Da):46,322
    Last modified:July 27, 2011 - v2
    Checksum:i451B6B875A6659A0
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti405 – 4051M → I in CAA44707. (PubMed:1370937)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X62934 mRNA. Translation: CAA44707.1.
    AK038558 mRNA. Translation: BAC30042.1.
    CH466523 Genomic DNA. Translation: EDK99033.1.
    BC075631 mRNA. Translation: AAH75631.1.
    BC098332 mRNA. Translation: AAH98332.1.
    L27828 mRNA. Translation: AAA17892.1.
    L27826 mRNA. Translation: AAA17891.1.
    CCDSiCCDS20262.1.
    PIRiS20304.
    RefSeqiNP_033339.2. NM_009313.5.
    XP_006505926.1. XM_006505863.1.
    XP_006505927.1. XM_006505864.1.
    XP_006505928.1. XM_006505865.1.
    UniGeneiMm.8055.

    Genome annotation databases

    EnsembliENSMUST00000032122; ENSMUSP00000032122; ENSMUSG00000030043.
    GeneIDi21336.
    KEGGimmu:21336.
    UCSCiuc009clh.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X62934 mRNA. Translation: CAA44707.1 .
    AK038558 mRNA. Translation: BAC30042.1 .
    CH466523 Genomic DNA. Translation: EDK99033.1 .
    BC075631 mRNA. Translation: AAH75631.1 .
    BC098332 mRNA. Translation: AAH98332.1 .
    L27828 mRNA. Translation: AAA17892.1 .
    L27826 mRNA. Translation: AAA17891.1 .
    CCDSi CCDS20262.1.
    PIRi S20304.
    RefSeqi NP_033339.2. NM_009313.5.
    XP_006505926.1. XM_006505863.1.
    XP_006505927.1. XM_006505864.1.
    XP_006505928.1. XM_006505865.1.
    UniGenei Mm.8055.

    3D structure databases

    ProteinModelPortali P30548.
    SMRi P30548. Positions 2-364.
    ModBasei Search...
    MobiDBi Search...

    Chemistry

    BindingDBi P30548.
    ChEMBLi CHEMBL2668.
    GuidetoPHARMACOLOGYi 360.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei P30548.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000032122 ; ENSMUSP00000032122 ; ENSMUSG00000030043 .
    GeneIDi 21336.
    KEGGi mmu:21336.
    UCSCi uc009clh.2. mouse.

    Organism-specific databases

    CTDi 6869.
    MGIi MGI:98475. Tacr1.

    Phylogenomic databases

    eggNOGi NOG331485.
    GeneTreei ENSGT00710000106471.
    HOGENOMi HOG000013018.
    HOVERGENi HBG103412.
    InParanoidi Q8BYR7.
    KOi K04222.
    OMAi MIIVVCT.
    OrthoDBi EOG7N37FW.
    TreeFami TF315303.

    Enzyme and pathway databases

    Reactomei REACT_207651. G alpha (q) signalling events.

    Miscellaneous databases

    NextBioi 300500.
    PROi P30548.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P30548.
    Bgeei P30548.
    CleanExi MM_TACR1.
    Genevestigatori P30548.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR001681. Neurokn_rcpt.
    IPR000046. NK1_rcpt.
    [Graphical view ]
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR01024. NEUROKININ1R.
    PR00244. NEUROKININR.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning of the murine substance K and substance P receptor genes."
      Sundelin J.B., Provvedini D.M., Wahlestedt C.R., Laurell H., Pohl J.S., Peterson P.A.
      Eur. J. Biochem. 203:625-631(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Intestine.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Hypothalamus.
    3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6.
      Tissue: Brain.
    5. "Molecular evidence that granuloma T lymphocytes in murine schistosomiasis mansoni express an authentic substance P (NK-1) receptor."
      Cook G.A., Elliott D., Metwali A., Blum A.M., Sandor M., Lynch R., Weinstock J.V.
      J. Immunol. 152:1830-1835(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 63-290.
      Strain: CBA.
      Tissue: Brain and T-cell.

    Entry informationi

    Entry nameiNK1R_MOUSE
    AccessioniPrimary (citable) accession number: P30548
    Secondary accession number(s): Q8BYR7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 1, 1993
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 110 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3