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Protein

Alpha-2B adrenergic receptor

Gene

Adra2b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei92Implicated in ligand bindingBy similarity1
Sitei176Implicated in catechol agonist bindingBy similarity1
Sitei180Implicated in catechol agonist bindingBy similarity1

GO - Molecular functioni

  • adrenergic receptor activity Source: MGI
  • alpha2-adrenergic receptor activity Source: MGI
  • epinephrine binding Source: MGI

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-2B adrenergic receptor
Alternative name(s):
Alpha-2B adrenoreceptor
Short name:
Alpha-2B adrenoceptor
Short name:
Alpha-2BAR
Gene namesi
Name:Adra2b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:87935. Adra2b.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 12ExtracellularBy similarityAdd BLAST12
Transmembranei13 – 37Helical; Name=1By similarityAdd BLAST25
Topological domaini38 – 49CytoplasmicBy similarityAdd BLAST12
Transmembranei50 – 75Helical; Name=2By similarityAdd BLAST26
Topological domaini76 – 85ExtracellularBy similarity10
Transmembranei86 – 108Helical; Name=3By similarityAdd BLAST23
Topological domaini109 – 130CytoplasmicBy similarityAdd BLAST22
Transmembranei131 – 153Helical; Name=4By similarityAdd BLAST23
Topological domaini154 – 169ExtracellularBy similarityAdd BLAST16
Transmembranei170 – 193Helical; Name=5By similarityAdd BLAST24
Topological domaini194 – 372CytoplasmicBy similarityAdd BLAST179
Transmembranei373 – 396Helical; Name=6By similarityAdd BLAST24
Topological domaini397 – 405ExtracellularBy similarity9
Transmembranei406 – 429Helical; Name=7By similarityAdd BLAST24
Topological domaini430 – 450CytoplasmicBy similarityAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL2405.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000690961 – 450Alpha-2B adrenergic receptorAdd BLAST450

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi85 ↔ 164PROSITE-ProRule annotation
Lipidationi442S-palmitoyl cysteineSequence analysis1

Keywords - PTMi

Disulfide bond, Lipoprotein, Palmitate

Proteomic databases

PaxDbiP30545.
PRIDEiP30545.

PTM databases

iPTMnetiP30545.
PhosphoSitePlusiP30545.

Expressioni

Gene expression databases

CleanExiMM_ADRA2B.

Interactioni

Subunit structurei

Interacts with RAB26. Interacts with PPP1R9B.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
EIF2B1Q142322EBI-491084,EBI-491065From a different organism.

Protein-protein interaction databases

IntActiP30545. 2 interactors.
MINTiMINT-4087111.
STRINGi10090.ENSMUSP00000071798.

Chemistry databases

BindingDBiP30545.

Structurei

3D structure databases

ProteinModelPortaliP30545.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi301 – 311Asp/Glu-rich (acidic)Add BLAST11

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA2B sub-subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
HOGENOMiHOG000239242.
HOVERGENiHBG106962.
InParanoidiP30545.
PhylomeDBiP30545.

Family and domain databases

InterProiIPR002233. ADR_fam.
IPR000207. ADRA2B_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01103. ADRENERGICR.
PR00559. ADRENRGCA2BR.
PR00237. GPCRRHODOPSN.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P30545-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVHQEPYSVQ ATAAIASAIT FLILFTIFGN ALVILAVLTS RSLRAPQNLF
60 70 80 90 100
LVSLAAADIL VATLIIPFSL ANELLGYWYF WRAWCEVYLA LDVLFCTSSI
110 120 130 140 150
VHLCAISLDR YWAVSRALEY NSKRTPRRIK CIILTVWLIA AVISLPPLIY
160 170 180 190 200
KGDQRPEPHG LPQCELNQEA WYILASSIGS FFAPCLIMIL VYLRIYVIAK
210 220 230 240 250
RSHCRGLGAK RGSGEGESKK PRPGPAAGGV PASAKVPTLV SPLSSVGEAN
260 270 280 290 300
GHPKPPREKE EGETPEDPEA RALPPNWSAL PRSVQDQKKG TSGATAEKGA
310 320 330 340 350
EEDEEEVEEC EPQTLPASPA SVFNPPLQQP QTSRVLATLR GQVLLSKNVG
360 370 380 390 400
VASGQWWRRR TQLSREKRFT FVLAVVIGVF VVCWFPFFFS YSLGAICPQH
410 420 430 440 450
CKVPHGLFQF FFWIGYCNSS LNPVIYTIFN QDFRRAFRRI LCRQWTQTGW
Length:450
Mass (Da):50,172
Last modified:June 21, 2005 - v2
Checksum:iA95DA296CA12A992
GO

Sequence cautioni

The sequence AAA73895 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti197V → L in AAA73895 (PubMed:1336396).Curated1
Sequence conflicti224 – 225Missing in AAA37131 (PubMed:1354956).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M94583 Genomic DNA. Translation: AAA73895.1. Different initiation.
L00979 Genomic DNA. Translation: AAA37131.1.
PIRiS28221.
UniGeneiMm.347390.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M94583 Genomic DNA. Translation: AAA73895.1. Different initiation.
L00979 Genomic DNA. Translation: AAA37131.1.
PIRiS28221.
UniGeneiMm.347390.

3D structure databases

ProteinModelPortaliP30545.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP30545. 2 interactors.
MINTiMINT-4087111.
STRINGi10090.ENSMUSP00000071798.

Chemistry databases

BindingDBiP30545.
ChEMBLiCHEMBL2405.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiP30545.
PhosphoSitePlusiP30545.

Proteomic databases

PaxDbiP30545.
PRIDEiP30545.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:87935. Adra2b.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
HOGENOMiHOG000239242.
HOVERGENiHBG106962.
InParanoidiP30545.
PhylomeDBiP30545.

Miscellaneous databases

PROiP30545.
SOURCEiSearch...

Gene expression databases

CleanExiMM_ADRA2B.

Family and domain databases

InterProiIPR002233. ADR_fam.
IPR000207. ADRA2B_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01103. ADRENERGICR.
PR00559. ADRENRGCA2BR.
PR00237. GPCRRHODOPSN.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiADA2B_MOUSE
AccessioniPrimary (citable) accession number: P30545
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: June 21, 2005
Last modified: November 2, 2016
This is version 138 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.