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P30545

- ADA2B_MOUSE

UniProt

P30545 - ADA2B_MOUSE

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Protein
Alpha-2B adrenergic receptor
Gene
Adra2b
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei92 – 921Implicated in ligand binding By similarity
Sitei176 – 1761Implicated in catechol agonist binding By similarity
Sitei180 – 1801Implicated in catechol agonist binding By similarity

GO - Molecular functioni

  1. alpha2-adrenergic receptor activity Source: InterPro
  2. protein binding Source: IntAct

GO - Biological processi

  1. platelet activation Source: InterPro
  2. regulation of smooth muscle contraction Source: InterPro
  3. regulation of vasoconstriction Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-2B adrenergic receptor
Alternative name(s):
Alpha-2B adrenoreceptor
Short name:
Alpha-2B adrenoceptor
Short name:
Alpha-2BAR
Gene namesi
Name:Adra2b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Unplaced

Organism-specific databases

MGIiMGI:87935. Adra2b.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1212Extracellular By similarity
Add
BLAST
Transmembranei13 – 3725Helical; Name=1; By similarity
Add
BLAST
Topological domaini38 – 4912Cytoplasmic By similarity
Add
BLAST
Transmembranei50 – 7526Helical; Name=2; By similarity
Add
BLAST
Topological domaini76 – 8510Extracellular By similarity
Transmembranei86 – 10823Helical; Name=3; By similarity
Add
BLAST
Topological domaini109 – 13022Cytoplasmic By similarity
Add
BLAST
Transmembranei131 – 15323Helical; Name=4; By similarity
Add
BLAST
Topological domaini154 – 16916Extracellular By similarity
Add
BLAST
Transmembranei170 – 19324Helical; Name=5; By similarity
Add
BLAST
Topological domaini194 – 372179Cytoplasmic By similarity
Add
BLAST
Transmembranei373 – 39624Helical; Name=6; By similarity
Add
BLAST
Topological domaini397 – 4059Extracellular By similarity
Transmembranei406 – 42924Helical; Name=7; By similarity
Add
BLAST
Topological domaini430 – 45021Cytoplasmic By similarity
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 450450Alpha-2B adrenergic receptor
PRO_0000069096Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi85 ↔ 164 By similarity
Lipidationi442 – 4421S-palmitoyl cysteine Reviewed prediction

Keywords - PTMi

Disulfide bond, Lipoprotein, Palmitate

Proteomic databases

PaxDbiP30545.
PRIDEiP30545.

Expressioni

Gene expression databases

CleanExiMM_ADRA2B.
GenevestigatoriP30545.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
EIF2B1Q142322EBI-491084,EBI-491065From a different organism.

Protein-protein interaction databases

IntActiP30545. 2 interactions.
MINTiMINT-4087111.
STRINGi10090.ENSMUSP00000071798.

Structurei

3D structure databases

ProteinModelPortaliP30545.
SMRiP30545. Positions 2-441.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi301 – 31111Asp/Glu-rich (acidic)
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG249628.
HOGENOMiHOG000239242.
HOVERGENiHBG106962.
InParanoidiP30545.
PhylomeDBiP30545.

Family and domain databases

Gene3Di1.20.1070.10. 2 hits.
InterProiIPR002233. ADR_fam.
IPR000207. ADRA2B_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24248:SF26. PTHR24248:SF26. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01103. ADRENERGICR.
PR00559. ADRENRGCA2BR.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P30545-1 [UniParc]FASTAAdd to Basket

« Hide

MVHQEPYSVQ ATAAIASAIT FLILFTIFGN ALVILAVLTS RSLRAPQNLF    50
LVSLAAADIL VATLIIPFSL ANELLGYWYF WRAWCEVYLA LDVLFCTSSI 100
VHLCAISLDR YWAVSRALEY NSKRTPRRIK CIILTVWLIA AVISLPPLIY 150
KGDQRPEPHG LPQCELNQEA WYILASSIGS FFAPCLIMIL VYLRIYVIAK 200
RSHCRGLGAK RGSGEGESKK PRPGPAAGGV PASAKVPTLV SPLSSVGEAN 250
GHPKPPREKE EGETPEDPEA RALPPNWSAL PRSVQDQKKG TSGATAEKGA 300
EEDEEEVEEC EPQTLPASPA SVFNPPLQQP QTSRVLATLR GQVLLSKNVG 350
VASGQWWRRR TQLSREKRFT FVLAVVIGVF VVCWFPFFFS YSLGAICPQH 400
CKVPHGLFQF FFWIGYCNSS LNPVIYTIFN QDFRRAFRRI LCRQWTQTGW 450
Length:450
Mass (Da):50,172
Last modified:June 21, 2005 - v2
Checksum:iA95DA296CA12A992
GO

Sequence cautioni

The sequence AAA73895.1 differs from that shown. Reason: Erroneous initiation.

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti197 – 1971V → L in AAA73895. 1 Publication
Sequence conflicti224 – 2252Missing1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M94583 Genomic DNA. Translation: AAA73895.1. Different initiation.
L00979 Genomic DNA. Translation: AAA37131.1.
PIRiS28221.
UniGeneiMm.347390.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M94583 Genomic DNA. Translation: AAA73895.1 . Different initiation.
L00979 Genomic DNA. Translation: AAA37131.1 .
PIRi S28221.
UniGenei Mm.347390.

3D structure databases

ProteinModelPortali P30545.
SMRi P30545. Positions 2-441.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P30545. 2 interactions.
MINTi MINT-4087111.
STRINGi 10090.ENSMUSP00000071798.

Chemistry

BindingDBi P30545.
ChEMBLi CHEMBL2405.
GuidetoPHARMACOLOGYi 26.

Protein family/group databases

GPCRDBi Search...

Proteomic databases

PaxDbi P30545.
PRIDEi P30545.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

MGIi MGI:87935. Adra2b.

Phylogenomic databases

eggNOGi NOG249628.
HOGENOMi HOG000239242.
HOVERGENi HBG106962.
InParanoidi P30545.
PhylomeDBi P30545.

Miscellaneous databases

PROi P30545.
SOURCEi Search...

Gene expression databases

CleanExi MM_ADRA2B.
Genevestigatori P30545.

Family and domain databases

Gene3Di 1.20.1070.10. 2 hits.
InterProi IPR002233. ADR_fam.
IPR000207. ADRA2B_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view ]
PANTHERi PTHR24248:SF26. PTHR24248:SF26. 1 hit.
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR01103. ADRENERGICR.
PR00559. ADRENRGCA2BR.
PR00237. GPCRRHODOPSN.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular cloning and characterization of a mouse alpha 2C2 adrenoceptor subtype gene."
    Chen W.-M., Chang A.C., Shie B.J., Chang Y.-H., Chang N.-C.A.
    Biochim. Biophys. Acta 1171:219-223(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: DBA/2.
    Tissue: Liver.
  2. "Cloning and expression of the mouse homolog of the human alpha 2-C2 adrenergic receptor."
    Chruscinski A.J., Link R.E., Daunt D.A., Barsh G.S., Kobilka B.K.
    Biochem. Biophys. Res. Commun. 186:1280-1287(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiADA2B_MOUSE
AccessioniPrimary (citable) accession number: P30545
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: June 21, 2005
Last modified: June 11, 2014
This is version 125 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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