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Protein

Adenosine receptor A1

Gene

ADORA1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-HSA-417973. Adenosine P1 receptors.
R-HSA-418594. G alpha (i) signalling events.

Protein family/group databases

TCDBi9.A.14.3.4. the g-protein-coupled receptor (gpcr) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Adenosine receptor A1
Gene namesi
Name:ADORA1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000163485.15.
HGNCiHGNC:262. ADORA1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 10ExtracellularSequence analysis10
Transmembranei11 – 33Helical; Name=1Sequence analysisAdd BLAST23
Topological domaini34 – 46CytoplasmicSequence analysisAdd BLAST13
Transmembranei47 – 69Helical; Name=2Sequence analysisAdd BLAST23
Topological domaini70 – 80ExtracellularSequence analysisAdd BLAST11
Transmembranei81 – 102Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini103 – 123CytoplasmicSequence analysisAdd BLAST21
Transmembranei124 – 146Helical; Name=4Sequence analysisAdd BLAST23
Topological domaini147 – 176ExtracellularSequence analysisAdd BLAST30
Transmembranei177 – 201Helical; Name=5Sequence analysisAdd BLAST25
Topological domaini202 – 235CytoplasmicSequence analysisAdd BLAST34
Transmembranei236 – 259Helical; Name=6Sequence analysisAdd BLAST24
Topological domaini260 – 267ExtracellularSequence analysis8
Transmembranei268 – 292Helical; Name=7Sequence analysisAdd BLAST25
Topological domaini293 – 326CytoplasmicSequence analysisAdd BLAST34

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi134.
OpenTargetsiENSG00000163485.
PharmGKBiPA24583.

Chemistry databases

ChEMBLiCHEMBL226.
DrugBankiDB00640. Adenosine.
DB01223. Aminophylline.
DB00201. Caffeine.
DB04932. Defibrotide.
DB00651. Dyphylline.
DB00824. Enprofylline.
DB00996. Gabapentin.
DB05360. KW-3902.
DB06471. Naxifylline.
DB01303. Oxtriphylline.
DB00806. Pentoxifylline.
DB04954. Tecadenoson.
DB01412. Theobromine.
DB00277. Theophylline.
GuidetoPHARMACOLOGYi18.

Polymorphism and mutation databases

BioMutaiADORA1.
DMDMi231473.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000689911 – 326Adenosine receptor A1Add BLAST326

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi80 ↔ 169PROSITE-ProRule annotation
Glycosylationi159N-linked (GlcNAc...) asparagineSequence analysis1
Lipidationi309S-palmitoyl cysteineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiP30542.
PeptideAtlasiP30542.
PRIDEiP30542.

PTM databases

iPTMnetiP30542.
PhosphoSitePlusiP30542.
SwissPalmiP30542.

Expressioni

Gene expression databases

BgeeiENSG00000163485.
CleanExiHS_ADORA1.
ExpressionAtlasiP30542. baseline and differential.
GenevisibleiP30542. HS.

Organism-specific databases

HPAiHPA044383.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
ADORA2AP292744EBI-2903663,EBI-2902702

GO - Molecular functioni

Protein-protein interaction databases

BioGridi106646. 7 interactors.
IntActiP30542. 2 interactors.
MINTiMINT-138736.
STRINGi9606.ENSP00000308549.

Chemistry databases

BindingDBiP30542.

Structurei

Secondary structure

1326
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi7 – 36Combined sources30
Helixi38 – 40Combined sources3
Helixi43 – 60Combined sources18
Helixi62 – 71Combined sources10
Helixi77 – 110Combined sources34
Turni112 – 114Combined sources3
Helixi115 – 118Combined sources4
Helixi121 – 140Combined sources20
Helixi141 – 144Combined sources4
Helixi149 – 159Combined sources11
Helixi171 – 174Combined sources4
Helixi177 – 182Combined sources6
Helixi184 – 188Combined sources5
Helixi190 – 221Combined sources32
Helixi225 – 259Combined sources35
Helixi267 – 291Combined sources25
Helixi293 – 306Combined sources14

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5UENX-ray3.20A/B2-211[»]
A/B228-311[»]
ProteinModelPortaliP30542.
SMRiP30542.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00550000074524.
HOVERGENiHBG106962.
InParanoidiP30542.
KOiK04265.
OMAiVWAVRIN.
OrthoDBiEOG091G0I3U.
PhylomeDBiP30542.
TreeFamiTF325296.

Family and domain databases

InterProiView protein in InterPro
IPR001068. Adeno_A1_rcpt.
IPR001634. Adenosn_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
PfamiView protein in Pfam
PF00001. 7tm_1. 1 hit.
PRINTSiPR00552. ADENOSINEA1R.
PR00424. ADENOSINER.
PR00237. GPCRRHODOPSN.
SMARTiView protein in SMART
SM01381. 7TM_GPCR_Srsx. 1 hit.
PROSITEiView protein in PROSITE
PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P30542-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPPSISAFQA AYIGIEVLIA LVSVPGNVLV IWAVKVNQAL RDATFCFIVS
60 70 80 90 100
LAVADVAVGA LVIPLAILIN IGPQTYFHTC LMVACPVLIL TQSSILALLA
110 120 130 140 150
IAVDRYLRVK IPLRYKMVVT PRRAAVAIAG CWILSFVVGL TPMFGWNNLS
160 170 180 190 200
AVERAWAANG SMGEPVIKCE FEKVISMEYM VYFNFFVWVL PPLLLMVLIY
210 220 230 240 250
LEVFYLIRKQ LNKKVSASSG DPQKYYGKEL KIAKSLALIL FLFALSWLPL
260 270 280 290 300
HILNCITLFC PSCHKPSILT YIAIFLTHGN SAMNPIVYAF RIQKFRVTFL
310 320
KIWNDHFRCQ PAPPIDEDLP EERPDD
Length:326
Mass (Da):36,512
Last modified:April 1, 1993 - v1
Checksum:i1B555893BCDEC9A6
GO
Isoform 2 (identifier: P30542-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     115-125: YKMVVTPRRAA → RISQCMASTKS
     126-326: Missing.

Show »
Length:125
Mass (Da):13,348
Checksum:i37CB91365D17A5F5
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti312A → T in BAF82617 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04413843A → S1 PublicationCorresponds to variant dbSNP:rs11547175Ensembl.1
Natural variantiVAR_04413950S → P1 PublicationCorresponds to variant dbSNP:rs11547174Ensembl.1
Natural variantiVAR_044140105R → H1 PublicationCorresponds to variant dbSNP:rs11547176Ensembl.1
Natural variantiVAR_035754170E → K in a colorectal cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_044141261P → Q1 PublicationCorresponds to variant dbSNP:rs17852405Ensembl.1
Natural variantiVAR_078549279G → S Found in a family with early-onset autosomal recessive parkinsonism and intellectual disability; unknown pathological significance; does not affect protein abundance; does not affect expression at the cell surface. 1 PublicationCorresponds to variant dbSNP:rs748346254Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_034401115 – 125YKMVVTPRRAA → RISQCMASTKS in isoform 2. 1 PublicationAdd BLAST11
Alternative sequenceiVSP_034402126 – 326Missing in isoform 2. 1 PublicationAdd BLAST201

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S45235 mRNA. Translation: AAB23388.1.
S56143 mRNA. Translation: AAB25533.2.
L22214 mRNA. Translation: AAA17544.1.
X68485 mRNA. Translation: CAA48503.1.
AB004662 mRNA. Translation: BAA20433.1.
EF057066 mRNA. Translation: ABO25743.1.
AK127752 mRNA. Translation: BAG54566.1.
AK289928 mRNA. Translation: BAF82617.1.
AY136746 mRNA. Translation: AAN01272.1.
BT019854 mRNA. Translation: AAV38657.1.
CR541749 mRNA. Translation: CAG46549.1.
AC105940 Genomic DNA. No translation available.
CH471067 Genomic DNA. Translation: EAW91465.1.
BC026340 mRNA. Translation: AAH26340.1.
CCDSiCCDS1434.1. [P30542-1]
PIRiA53005.
RefSeqiNP_000665.1. NM_000674.2. [P30542-1]
NP_001041695.1. NM_001048230.1. [P30542-1]
UniGeneiHs.77867.

Genome annotation databases

EnsembliENST00000309502; ENSP00000308549; ENSG00000163485. [P30542-1]
ENST00000337894; ENSP00000338435; ENSG00000163485. [P30542-1]
ENST00000367235; ENSP00000356204; ENSG00000163485. [P30542-2]
ENST00000367236; ENSP00000356205; ENSG00000163485. [P30542-1]
ENST00000640524; ENSP00000491900; ENSG00000163485. [P30542-2]
GeneIDi134.
KEGGihsa:134.
UCSCiuc001gze.1. human. [P30542-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiAA1R_HUMAN
AccessioniPrimary (citable) accession number: P30542
Secondary accession number(s): A6NFY5
, A6NGP4, A8K1L3, B3KXQ4, D2CGD0, Q6FHK3, Q8TAM8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: September 27, 2017
This is version 165 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families