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P30542

- AA1R_HUMAN

UniProt

P30542 - AA1R_HUMAN

Protein

Adenosine receptor A1

Gene

ADORA1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 140 (01 Oct 2014)
      Sequence version 1 (01 Apr 1993)
      Previous versions | rss
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    Functioni

    Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase.

    GO - Molecular functioni

    1. G-protein coupled adenosine receptor activity Source: InterPro
    2. phospholipase C activity Source: Ensembl
    3. protein binding Source: IntAct
    4. purine nucleoside binding Source: Ensembl

    GO - Biological processi

    1. activation of MAPKK activity Source: Ensembl
    2. adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway Source: Ensembl
    3. apoptotic signaling pathway Source: ProtInc
    4. cell-cell signaling Source: ProtInc
    5. cognition Source: Ensembl
    6. detection of temperature stimulus involved in sensory perception of pain Source: Ensembl
    7. inflammatory response Source: ProtInc
    8. lipid catabolic process Source: Ensembl
    9. negative regulation of acute inflammatory response Source: Ensembl
    10. negative regulation of apoptotic process Source: Ensembl
    11. negative regulation of blood pressure Source: Ensembl
    12. negative regulation of cardiac muscle contraction Source: Ensembl
    13. negative regulation of cell proliferation Source: Ensembl
    14. negative regulation of circadian sleep/wake cycle, non-REM sleep Source: Ensembl
    15. negative regulation of glutamate secretion Source: Ensembl
    16. negative regulation of heart contraction Source: Ensembl
    17. negative regulation of hormone secretion Source: Ensembl
    18. negative regulation of leukocyte migration Source: Ensembl
    19. negative regulation of lipid catabolic process Source: Ensembl
    20. negative regulation of mucus secretion Source: Ensembl
    21. negative regulation of neurotrophin production Source: Ensembl
    22. negative regulation of renal sodium excretion Source: Ensembl
    23. negative regulation of synaptic transmission, GABAergic Source: Ensembl
    24. negative regulation of synaptic transmission, glutamatergic Source: Ensembl
    25. negative regulation of vasodilation Source: Ensembl
    26. nervous system development Source: ProtInc
    27. phagocytosis Source: ProtInc
    28. positive regulation of blood pressure Source: Ensembl
    29. positive regulation of epidermal growth factor-activated receptor activity Source: Ensembl
    30. positive regulation of nucleoside transport Source: Ensembl
    31. positive regulation of peptide secretion Source: Ensembl
    32. positive regulation of potassium ion transport Source: Ensembl
    33. positive regulation of protein dephosphorylation Source: Ensembl
    34. protein targeting to membrane Source: Ensembl
    35. regulation of excitatory postsynaptic membrane potential Source: Ensembl
    36. regulation of glomerular filtration Source: Ensembl
    37. regulation of respiratory gaseous exchange by neurological system process Source: Ensembl
    38. regulation of synaptic plasticity Source: Ensembl
    39. relaxation of vascular smooth muscle Source: Ensembl
    40. response to hypoxia Source: Ensembl
    41. signal transduction Source: ProtInc
    42. temperature homeostasis Source: Ensembl

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Enzyme and pathway databases

    ReactomeiREACT_18288. Adenosine P1 receptors.
    REACT_19231. G alpha (i) signalling events.

    Protein family/group databases

    TCDBi9.A.14.3.4. the g-protein-coupled receptor (gpcr) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Adenosine receptor A1
    Gene namesi
    Name:ADORA1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:262. ADORA1.

    Subcellular locationi

    GO - Cellular componenti

    1. asymmetric synapse Source: Ensembl
    2. axolemma Source: Ensembl
    3. basolateral plasma membrane Source: Ensembl
    4. dendrite Source: Ensembl
    5. endoplasmic reticulum Source: Ensembl
    6. integral component of plasma membrane Source: ProtInc
    7. neuronal cell body Source: Ensembl
    8. plasma membrane Source: Reactome
    9. postsynaptic density Source: Ensembl
    10. postsynaptic membrane Source: Ensembl
    11. presynaptic active zone Source: Ensembl
    12. presynaptic membrane Source: Ensembl
    13. terminal bouton Source: Ensembl

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA24583.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 326326Adenosine receptor A1PRO_0000068991Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi80 ↔ 169PROSITE-ProRule annotation
    Glycosylationi159 – 1591N-linked (GlcNAc...)Sequence Analysis
    Lipidationi309 – 3091S-palmitoyl cysteineSequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

    Proteomic databases

    PaxDbiP30542.
    PRIDEiP30542.

    PTM databases

    PhosphoSiteiP30542.

    Expressioni

    Gene expression databases

    ArrayExpressiP30542.
    BgeeiP30542.
    CleanExiHS_ADORA1.
    GenevestigatoriP30542.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    ADORA2AP292744EBI-2903663,EBI-2902702

    Protein-protein interaction databases

    BioGridi106646. 7 interactions.
    IntActiP30542. 2 interactions.
    MINTiMINT-138736.
    STRINGi9606.ENSP00000308549.

    Structurei

    3D structure databases

    ProteinModelPortaliP30542.
    SMRiP30542. Positions 10-306.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 1010ExtracellularSequence Analysis
    Topological domaini34 – 4613CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini70 – 8011ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini103 – 12321CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini147 – 17630ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini202 – 23534CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini260 – 2678ExtracellularSequence Analysis
    Topological domaini293 – 32634CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei11 – 3323Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei47 – 6923Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei81 – 10222Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei124 – 14623Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei177 – 20125Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei236 – 25924Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei268 – 29225Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG284456.
    HOVERGENiHBG106962.
    InParanoidiP30542.
    KOiK04265.
    OMAiIPLRYKM.
    OrthoDBiEOG79SDXQ.
    PhylomeDBiP30542.
    TreeFamiTF325296.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR001068. Adeno_A1_rcpt.
    IPR001634. Adenosn_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view]
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00552. ADENOSINEA1R.
    PR00424. ADENOSINER.
    PR00237. GPCRRHODOPSN.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P30542-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MPPSISAFQA AYIGIEVLIA LVSVPGNVLV IWAVKVNQAL RDATFCFIVS    50
    LAVADVAVGA LVIPLAILIN IGPQTYFHTC LMVACPVLIL TQSSILALLA 100
    IAVDRYLRVK IPLRYKMVVT PRRAAVAIAG CWILSFVVGL TPMFGWNNLS 150
    AVERAWAANG SMGEPVIKCE FEKVISMEYM VYFNFFVWVL PPLLLMVLIY 200
    LEVFYLIRKQ LNKKVSASSG DPQKYYGKEL KIAKSLALIL FLFALSWLPL 250
    HILNCITLFC PSCHKPSILT YIAIFLTHGN SAMNPIVYAF RIQKFRVTFL 300
    KIWNDHFRCQ PAPPIDEDLP EERPDD 326
    Length:326
    Mass (Da):36,512
    Last modified:April 1, 1993 - v1
    Checksum:i1B555893BCDEC9A6
    GO
    Isoform 2 (identifier: P30542-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         115-125: YKMVVTPRRAA → RISQCMASTKS
         126-326: Missing.

    Show »
    Length:125
    Mass (Da):13,348
    Checksum:i37CB91365D17A5F5
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti312 – 3121A → T in BAF82617. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti43 – 431A → S.1 Publication
    Corresponds to variant rs11547175 [ dbSNP | Ensembl ].
    VAR_044138
    Natural varianti50 – 501S → P.1 Publication
    Corresponds to variant rs11547174 [ dbSNP | Ensembl ].
    VAR_044139
    Natural varianti105 – 1051R → H.1 Publication
    Corresponds to variant rs11547176 [ dbSNP | Ensembl ].
    VAR_044140
    Natural varianti170 – 1701E → K in a colorectal cancer sample; somatic mutation. 1 Publication
    VAR_035754
    Natural varianti261 – 2611P → Q.1 Publication
    Corresponds to variant rs17852405 [ dbSNP | Ensembl ].
    VAR_044141

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei115 – 12511YKMVVTPRRAA → RISQCMASTKS in isoform 2. 1 PublicationVSP_034401Add
    BLAST
    Alternative sequencei126 – 326201Missing in isoform 2. 1 PublicationVSP_034402Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S45235 mRNA. Translation: AAB23388.1.
    S56143 mRNA. Translation: AAB25533.2.
    L22214 mRNA. Translation: AAA17544.1.
    X68485 mRNA. Translation: CAA48503.1.
    AB004662 mRNA. Translation: BAA20433.1.
    EF057066 mRNA. Translation: ABO25743.1.
    AK127752 mRNA. Translation: BAG54566.1.
    AK289928 mRNA. Translation: BAF82617.1.
    AY136746 mRNA. Translation: AAN01272.1.
    BT019854 mRNA. Translation: AAV38657.1.
    CR541749 mRNA. Translation: CAG46549.1.
    AC105940 Genomic DNA. No translation available.
    CH471067 Genomic DNA. Translation: EAW91465.1.
    BC026340 mRNA. Translation: AAH26340.1.
    CCDSiCCDS1434.1. [P30542-1]
    PIRiA53005.
    RefSeqiNP_000665.1. NM_000674.2. [P30542-1]
    NP_001041695.1. NM_001048230.1. [P30542-1]
    UniGeneiHs.77867.

    Genome annotation databases

    EnsembliENST00000309502; ENSP00000308549; ENSG00000163485. [P30542-1]
    ENST00000337894; ENSP00000338435; ENSG00000163485. [P30542-1]
    ENST00000367235; ENSP00000356204; ENSG00000163485. [P30542-2]
    ENST00000367236; ENSP00000356205; ENSG00000163485. [P30542-1]
    GeneIDi134.
    KEGGihsa:134.
    UCSCiuc001gze.1. human. [P30542-1]

    Polymorphism databases

    DMDMi231473.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S45235 mRNA. Translation: AAB23388.1 .
    S56143 mRNA. Translation: AAB25533.2 .
    L22214 mRNA. Translation: AAA17544.1 .
    X68485 mRNA. Translation: CAA48503.1 .
    AB004662 mRNA. Translation: BAA20433.1 .
    EF057066 mRNA. Translation: ABO25743.1 .
    AK127752 mRNA. Translation: BAG54566.1 .
    AK289928 mRNA. Translation: BAF82617.1 .
    AY136746 mRNA. Translation: AAN01272.1 .
    BT019854 mRNA. Translation: AAV38657.1 .
    CR541749 mRNA. Translation: CAG46549.1 .
    AC105940 Genomic DNA. No translation available.
    CH471067 Genomic DNA. Translation: EAW91465.1 .
    BC026340 mRNA. Translation: AAH26340.1 .
    CCDSi CCDS1434.1. [P30542-1 ]
    PIRi A53005.
    RefSeqi NP_000665.1. NM_000674.2. [P30542-1 ]
    NP_001041695.1. NM_001048230.1. [P30542-1 ]
    UniGenei Hs.77867.

    3D structure databases

    ProteinModelPortali P30542.
    SMRi P30542. Positions 10-306.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 106646. 7 interactions.
    IntActi P30542. 2 interactions.
    MINTi MINT-138736.
    STRINGi 9606.ENSP00000308549.

    Chemistry

    BindingDBi P30542.
    ChEMBLi CHEMBL226.
    DrugBanki DB01223. Aminophylline.
    DB00201. Caffeine.
    DB04932. Defibrotide.
    DB00996. Gabapentin.
    DB00458. Imipramine.
    DB00061. Pegademase bovine.
    DB00277. Theophylline.
    GuidetoPHARMACOLOGYi 18.

    Protein family/group databases

    TCDBi 9.A.14.3.4. the g-protein-coupled receptor (gpcr) family.
    GPCRDBi Search...

    PTM databases

    PhosphoSitei P30542.

    Polymorphism databases

    DMDMi 231473.

    Proteomic databases

    PaxDbi P30542.
    PRIDEi P30542.

    Protocols and materials databases

    DNASUi 134.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000309502 ; ENSP00000308549 ; ENSG00000163485 . [P30542-1 ]
    ENST00000337894 ; ENSP00000338435 ; ENSG00000163485 . [P30542-1 ]
    ENST00000367235 ; ENSP00000356204 ; ENSG00000163485 . [P30542-2 ]
    ENST00000367236 ; ENSP00000356205 ; ENSG00000163485 . [P30542-1 ]
    GeneIDi 134.
    KEGGi hsa:134.
    UCSCi uc001gze.1. human. [P30542-1 ]

    Organism-specific databases

    CTDi 134.
    GeneCardsi GC01P203059.
    HGNCi HGNC:262. ADORA1.
    MIMi 102775. gene.
    neXtProti NX_P30542.
    PharmGKBi PA24583.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG284456.
    HOVERGENi HBG106962.
    InParanoidi P30542.
    KOi K04265.
    OMAi IPLRYKM.
    OrthoDBi EOG79SDXQ.
    PhylomeDBi P30542.
    TreeFami TF325296.

    Enzyme and pathway databases

    Reactomei REACT_18288. Adenosine P1 receptors.
    REACT_19231. G alpha (i) signalling events.

    Miscellaneous databases

    ChiTaRSi ADORA1. human.
    GeneWikii Adenosine_A1_receptor.
    GenomeRNAii 134.
    NextBioi 35489211.
    PROi P30542.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P30542.
    Bgeei P30542.
    CleanExi HS_ADORA1.
    Genevestigatori P30542.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR001068. Adeno_A1_rcpt.
    IPR001634. Adenosn_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view ]
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00552. ADENOSINEA1R.
    PR00424. ADENOSINER.
    PR00237. GPCRRHODOPSN.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Hippocampus.
    2. "Molecular cloning and characterisation of a human brain A1 adenosine receptor cDNA."
      Townsend-Nicholson A., Shine J.
      Brain Res. Mol. Brain Res. 16:365-370(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Brain.
    3. "Characterization of the human A1 adenosine receptor gene. Evidence for alternative splicing."
      Ren H., Stiles G.L.
      J. Biol. Chem. 269:3104-3110(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Hippocampus.
    4. Salvatore C.A., Luneau C.J., Johnson R.G., Jacobson M.
      Submitted (SEP-1992) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Brain.
    5. "Complete nucleotide sequence of an adenosine A1-receptor from heart."
      Hirabatake Y., Takao K., Hagiwara S., Kasanuki H., Hosoda S., Kokubun S.
      Submitted (JUN-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Heart.
    6. "Identification of a 3TM adenosine receptor subtype 1 variant."
      Feng Y.-H., Cheng H., Qiu R.
      Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    7. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain and Hippocampus.
    8. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
      Puhl H.L. III, Ikeda S.R., Aronstam R.S.
      Submitted (JUL-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain.
    9. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
      Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    10. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    11. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    12. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    13. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS SER-43; PRO-50; HIS-105 AND GLN-261.
      Tissue: Brain.
    14. Cited for: VARIANT [LARGE SCALE ANALYSIS] LYS-170.

    Entry informationi

    Entry nameiAA1R_HUMAN
    AccessioniPrimary (citable) accession number: P30542
    Secondary accession number(s): A6NFY5
    , A6NGP4, A8K1L3, B3KXQ4, D2CGD0, Q6FHK3, Q8TAM8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 1, 1993
    Last sequence update: April 1, 1993
    Last modified: October 1, 2014
    This is version 140 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3