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P30542

- AA1R_HUMAN

UniProt

P30542 - AA1R_HUMAN

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Protein
Adenosine receptor A1
Gene
ADORA1
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase.

GO - Molecular functioni

  1. G-protein coupled adenosine receptor activity Source: InterPro
  2. phospholipase C activity Source: Ensembl
  3. protein binding Source: IntAct
  4. purine nucleoside binding Source: Ensembl

GO - Biological processi

  1. activation of MAPKK activity Source: Ensembl
  2. adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway Source: Ensembl
  3. apoptotic signaling pathway Source: ProtInc
  4. cell-cell signaling Source: ProtInc
  5. cognition Source: Ensembl
  6. detection of temperature stimulus involved in sensory perception of pain Source: Ensembl
  7. inflammatory response Source: ProtInc
  8. lipid catabolic process Source: Ensembl
  9. negative regulation of acute inflammatory response Source: Ensembl
  10. negative regulation of apoptotic process Source: Ensembl
  11. negative regulation of blood pressure Source: Ensembl
  12. negative regulation of cardiac muscle contraction Source: Ensembl
  13. negative regulation of cell proliferation Source: Ensembl
  14. negative regulation of circadian sleep/wake cycle, non-REM sleep Source: Ensembl
  15. negative regulation of glutamate secretion Source: Ensembl
  16. negative regulation of heart contraction Source: Ensembl
  17. negative regulation of hormone secretion Source: Ensembl
  18. negative regulation of leukocyte migration Source: Ensembl
  19. negative regulation of lipid catabolic process Source: Ensembl
  20. negative regulation of mucus secretion Source: Ensembl
  21. negative regulation of neurotrophin production Source: Ensembl
  22. negative regulation of renal sodium excretion Source: Ensembl
  23. negative regulation of synaptic transmission, GABAergic Source: Ensembl
  24. negative regulation of synaptic transmission, glutamatergic Source: Ensembl
  25. negative regulation of vasodilation Source: Ensembl
  26. nervous system development Source: ProtInc
  27. phagocytosis Source: ProtInc
  28. positive regulation of blood pressure Source: Ensembl
  29. positive regulation of epidermal growth factor-activated receptor activity Source: Ensembl
  30. positive regulation of nucleoside transport Source: Ensembl
  31. positive regulation of peptide secretion Source: Ensembl
  32. positive regulation of potassium ion transport Source: Ensembl
  33. positive regulation of protein dephosphorylation Source: Ensembl
  34. protein targeting to membrane Source: Ensembl
  35. regulation of excitatory postsynaptic membrane potential Source: Ensembl
  36. regulation of glomerular filtration Source: Ensembl
  37. regulation of respiratory gaseous exchange by neurological system process Source: Ensembl
  38. regulation of synaptic plasticity Source: Ensembl
  39. relaxation of vascular smooth muscle Source: Ensembl
  40. response to hypoxia Source: Ensembl
  41. signal transduction Source: ProtInc
  42. temperature homeostasis Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_18288. Adenosine P1 receptors.
REACT_19231. G alpha (i) signalling events.

Protein family/group databases

TCDBi9.A.14.3.4. the g-protein-coupled receptor (gpcr) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Adenosine receptor A1
Gene namesi
Name:ADORA1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:262. ADORA1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1010Extracellular Reviewed prediction
Transmembranei11 – 3323Helical; Name=1; Reviewed prediction
Add
BLAST
Topological domaini34 – 4613Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei47 – 6923Helical; Name=2; Reviewed prediction
Add
BLAST
Topological domaini70 – 8011Extracellular Reviewed prediction
Add
BLAST
Transmembranei81 – 10222Helical; Name=3; Reviewed prediction
Add
BLAST
Topological domaini103 – 12321Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei124 – 14623Helical; Name=4; Reviewed prediction
Add
BLAST
Topological domaini147 – 17630Extracellular Reviewed prediction
Add
BLAST
Transmembranei177 – 20125Helical; Name=5; Reviewed prediction
Add
BLAST
Topological domaini202 – 23534Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei236 – 25924Helical; Name=6; Reviewed prediction
Add
BLAST
Topological domaini260 – 2678Extracellular Reviewed prediction
Transmembranei268 – 29225Helical; Name=7; Reviewed prediction
Add
BLAST
Topological domaini293 – 32634Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. asymmetric synapse Source: Ensembl
  2. axolemma Source: Ensembl
  3. basolateral plasma membrane Source: Ensembl
  4. dendrite Source: Ensembl
  5. endoplasmic reticulum Source: Ensembl
  6. integral component of plasma membrane Source: ProtInc
  7. neuronal cell body Source: Ensembl
  8. plasma membrane Source: Reactome
  9. postsynaptic density Source: Ensembl
  10. postsynaptic membrane Source: Ensembl
  11. presynaptic active zone Source: Ensembl
  12. presynaptic membrane Source: Ensembl
  13. terminal bouton Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA24583.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 326326Adenosine receptor A1
PRO_0000068991Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi80 ↔ 169 By similarity
Glycosylationi159 – 1591N-linked (GlcNAc...) Reviewed prediction
Lipidationi309 – 3091S-palmitoyl cysteine Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiP30542.
PRIDEiP30542.

PTM databases

PhosphoSiteiP30542.

Expressioni

Gene expression databases

ArrayExpressiP30542.
BgeeiP30542.
CleanExiHS_ADORA1.
GenevestigatoriP30542.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
ADORA2AP292744EBI-2903663,EBI-2902702

Protein-protein interaction databases

BioGridi106646. 7 interactions.
IntActiP30542. 2 interactions.
MINTiMINT-138736.
STRINGi9606.ENSP00000308549.

Structurei

3D structure databases

ProteinModelPortaliP30542.
SMRiP30542. Positions 10-306.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG284456.
HOVERGENiHBG106962.
InParanoidiP30542.
KOiK04265.
OMAiIPLRYKM.
OrthoDBiEOG79SDXQ.
PhylomeDBiP30542.
TreeFamiTF325296.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR001068. Adeno_A1_rcpt.
IPR001634. Adenosn_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00552. ADENOSINEA1R.
PR00424. ADENOSINER.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P30542-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MPPSISAFQA AYIGIEVLIA LVSVPGNVLV IWAVKVNQAL RDATFCFIVS    50
LAVADVAVGA LVIPLAILIN IGPQTYFHTC LMVACPVLIL TQSSILALLA 100
IAVDRYLRVK IPLRYKMVVT PRRAAVAIAG CWILSFVVGL TPMFGWNNLS 150
AVERAWAANG SMGEPVIKCE FEKVISMEYM VYFNFFVWVL PPLLLMVLIY 200
LEVFYLIRKQ LNKKVSASSG DPQKYYGKEL KIAKSLALIL FLFALSWLPL 250
HILNCITLFC PSCHKPSILT YIAIFLTHGN SAMNPIVYAF RIQKFRVTFL 300
KIWNDHFRCQ PAPPIDEDLP EERPDD 326
Length:326
Mass (Da):36,512
Last modified:April 1, 1993 - v1
Checksum:i1B555893BCDEC9A6
GO
Isoform 2 (identifier: P30542-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     115-125: YKMVVTPRRAA → RISQCMASTKS
     126-326: Missing.

Show »
Length:125
Mass (Da):13,348
Checksum:i37CB91365D17A5F5
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti43 – 431A → S.1 Publication
Corresponds to variant rs11547175 [ dbSNP | Ensembl ].
VAR_044138
Natural varianti50 – 501S → P.1 Publication
Corresponds to variant rs11547174 [ dbSNP | Ensembl ].
VAR_044139
Natural varianti105 – 1051R → H.1 Publication
Corresponds to variant rs11547176 [ dbSNP | Ensembl ].
VAR_044140
Natural varianti170 – 1701E → K in a colorectal cancer sample; somatic mutation. 1 Publication
VAR_035754
Natural varianti261 – 2611P → Q.1 Publication
Corresponds to variant rs17852405 [ dbSNP | Ensembl ].
VAR_044141

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei115 – 12511YKMVVTPRRAA → RISQCMASTKS in isoform 2.
VSP_034401Add
BLAST
Alternative sequencei126 – 326201Missing in isoform 2.
VSP_034402Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti312 – 3121A → T in BAF82617. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
S45235 mRNA. Translation: AAB23388.1.
S56143 mRNA. Translation: AAB25533.2.
L22214 mRNA. Translation: AAA17544.1.
X68485 mRNA. Translation: CAA48503.1.
AB004662 mRNA. Translation: BAA20433.1.
EF057066 mRNA. Translation: ABO25743.1.
AK127752 mRNA. Translation: BAG54566.1.
AK289928 mRNA. Translation: BAF82617.1.
AY136746 mRNA. Translation: AAN01272.1.
BT019854 mRNA. Translation: AAV38657.1.
CR541749 mRNA. Translation: CAG46549.1.
AC105940 Genomic DNA. No translation available.
CH471067 Genomic DNA. Translation: EAW91465.1.
BC026340 mRNA. Translation: AAH26340.1.
CCDSiCCDS1434.1. [P30542-1]
PIRiA53005.
RefSeqiNP_000665.1. NM_000674.2. [P30542-1]
NP_001041695.1. NM_001048230.1. [P30542-1]
UniGeneiHs.77867.

Genome annotation databases

EnsembliENST00000309502; ENSP00000308549; ENSG00000163485. [P30542-1]
ENST00000337894; ENSP00000338435; ENSG00000163485. [P30542-1]
ENST00000367235; ENSP00000356204; ENSG00000163485. [P30542-2]
ENST00000367236; ENSP00000356205; ENSG00000163485. [P30542-1]
GeneIDi134.
KEGGihsa:134.
UCSCiuc001gze.1. human. [P30542-1]

Polymorphism databases

DMDMi231473.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
S45235 mRNA. Translation: AAB23388.1 .
S56143 mRNA. Translation: AAB25533.2 .
L22214 mRNA. Translation: AAA17544.1 .
X68485 mRNA. Translation: CAA48503.1 .
AB004662 mRNA. Translation: BAA20433.1 .
EF057066 mRNA. Translation: ABO25743.1 .
AK127752 mRNA. Translation: BAG54566.1 .
AK289928 mRNA. Translation: BAF82617.1 .
AY136746 mRNA. Translation: AAN01272.1 .
BT019854 mRNA. Translation: AAV38657.1 .
CR541749 mRNA. Translation: CAG46549.1 .
AC105940 Genomic DNA. No translation available.
CH471067 Genomic DNA. Translation: EAW91465.1 .
BC026340 mRNA. Translation: AAH26340.1 .
CCDSi CCDS1434.1. [P30542-1 ]
PIRi A53005.
RefSeqi NP_000665.1. NM_000674.2. [P30542-1 ]
NP_001041695.1. NM_001048230.1. [P30542-1 ]
UniGenei Hs.77867.

3D structure databases

ProteinModelPortali P30542.
SMRi P30542. Positions 10-306.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 106646. 7 interactions.
IntActi P30542. 2 interactions.
MINTi MINT-138736.
STRINGi 9606.ENSP00000308549.

Chemistry

BindingDBi P30542.
ChEMBLi CHEMBL226.
DrugBanki DB01223. Aminophylline.
DB00201. Caffeine.
DB04932. Defibrotide.
DB00996. Gabapentin.
DB00458. Imipramine.
DB00061. Pegademase bovine.
DB00277. Theophylline.
GuidetoPHARMACOLOGYi 18.

Protein family/group databases

TCDBi 9.A.14.3.4. the g-protein-coupled receptor (gpcr) family.
GPCRDBi Search...

PTM databases

PhosphoSitei P30542.

Polymorphism databases

DMDMi 231473.

Proteomic databases

PaxDbi P30542.
PRIDEi P30542.

Protocols and materials databases

DNASUi 134.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000309502 ; ENSP00000308549 ; ENSG00000163485 . [P30542-1 ]
ENST00000337894 ; ENSP00000338435 ; ENSG00000163485 . [P30542-1 ]
ENST00000367235 ; ENSP00000356204 ; ENSG00000163485 . [P30542-2 ]
ENST00000367236 ; ENSP00000356205 ; ENSG00000163485 . [P30542-1 ]
GeneIDi 134.
KEGGi hsa:134.
UCSCi uc001gze.1. human. [P30542-1 ]

Organism-specific databases

CTDi 134.
GeneCardsi GC01P203059.
HGNCi HGNC:262. ADORA1.
MIMi 102775. gene.
neXtProti NX_P30542.
PharmGKBi PA24583.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG284456.
HOVERGENi HBG106962.
InParanoidi P30542.
KOi K04265.
OMAi IPLRYKM.
OrthoDBi EOG79SDXQ.
PhylomeDBi P30542.
TreeFami TF325296.

Enzyme and pathway databases

Reactomei REACT_18288. Adenosine P1 receptors.
REACT_19231. G alpha (i) signalling events.

Miscellaneous databases

ChiTaRSi ADORA1. human.
GeneWikii Adenosine_A1_receptor.
GenomeRNAii 134.
NextBioi 35489211.
PROi P30542.
SOURCEi Search...

Gene expression databases

ArrayExpressi P30542.
Bgeei P30542.
CleanExi HS_ADORA1.
Genevestigatori P30542.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR001068. Adeno_A1_rcpt.
IPR001634. Adenosn_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view ]
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00552. ADENOSINEA1R.
PR00424. ADENOSINER.
PR00237. GPCRRHODOPSN.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Hippocampus.
  2. "Molecular cloning and characterisation of a human brain A1 adenosine receptor cDNA."
    Townsend-Nicholson A., Shine J.
    Brain Res. Mol. Brain Res. 16:365-370(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Brain.
  3. "Characterization of the human A1 adenosine receptor gene. Evidence for alternative splicing."
    Ren H., Stiles G.L.
    J. Biol. Chem. 269:3104-3110(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Hippocampus.
  4. Salvatore C.A., Luneau C.J., Johnson R.G., Jacobson M.
    Submitted (SEP-1992) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Brain.
  5. "Complete nucleotide sequence of an adenosine A1-receptor from heart."
    Hirabatake Y., Takao K., Hagiwara S., Kasanuki H., Hosoda S., Kokubun S.
    Submitted (JUN-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Heart.
  6. "Identification of a 3TM adenosine receptor subtype 1 variant."
    Feng Y.-H., Cheng H., Qiu R.
    Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
  7. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain and Hippocampus.
  8. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
    Puhl H.L. III, Ikeda S.R., Aronstam R.S.
    Submitted (JUL-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  9. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  10. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  11. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  12. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  13. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS SER-43; PRO-50; HIS-105 AND GLN-261.
    Tissue: Brain.
  14. Cited for: VARIANT [LARGE SCALE ANALYSIS] LYS-170.

Entry informationi

Entry nameiAA1R_HUMAN
AccessioniPrimary (citable) accession number: P30542
Secondary accession number(s): A6NFY5
, A6NGP4, A8K1L3, B3KXQ4, D2CGD0, Q6FHK3, Q8TAM8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: September 3, 2014
This is version 139 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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