P30542 (AA1R_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Adenosine receptor A1

Gene names

Name:

ADORA1

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	326 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein Lipoprotein Palmitate
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	activation of MAPKK activity Inferred from electronic annotation. Source: Compara adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway Inferred from electronic annotation. Source: Compara apoptotic signaling pathway Traceable author statement PubMed 7818494. Source: ProtInc cell-cell signaling Traceable author statement PubMed 7818494. Source: ProtInc cognition Inferred from electronic annotation. Source: Compara detection of temperature stimulus involved in sensory perception of pain Inferred from electronic annotation. Source: Compara inflammatory response Traceable author statement PubMed 8360491. Source: ProtInc lipid catabolic process Inferred from electronic annotation. Source: Compara negative regulation of acute inflammatory response Inferred from electronic annotation. Source: Compara negative regulation of apoptotic process Inferred from electronic annotation. Source: Compara negative regulation of blood pressure Inferred from electronic annotation. Source: Compara negative regulation of cardiac muscle contraction Inferred from electronic annotation. Source: Compara negative regulation of cell proliferation Inferred from electronic annotation. Source: Compara negative regulation of circadian sleep/wake cycle, non-REM sleep Inferred from electronic annotation. Source: Compara negative regulation of glutamate secretion Inferred from electronic annotation. Source: Compara negative regulation of heart contraction Inferred from electronic annotation. Source: Compara negative regulation of hormone secretion Inferred from electronic annotation. Source: Compara negative regulation of leukocyte migration Inferred from electronic annotation. Source: Compara negative regulation of lipid catabolic process Inferred from electronic annotation. Source: Compara negative regulation of mucus secretion Inferred from electronic annotation. Source: Compara negative regulation of neurotrophin production Inferred from electronic annotation. Source: Compara negative regulation of renal sodium excretion Inferred from electronic annotation. Source: Compara negative regulation of synaptic transmission, GABAergic Inferred from electronic annotation. Source: Compara negative regulation of synaptic transmission, glutamatergic Inferred from electronic annotation. Source: Compara negative regulation of vasodilation Inferred from electronic annotation. Source: Compara nervous system development Traceable author statement PubMed 8450977. Source: ProtInc phagocytosis Traceable author statement PubMed 8360491. Source: ProtInc positive regulation of blood pressure Inferred from electronic annotation. Source: Compara positive regulation of epidermal growth factor-activated receptor activity Inferred from electronic annotation. Source: Compara positive regulation of nucleoside transport Inferred from electronic annotation. Source: Compara positive regulation of peptide secretion Inferred from electronic annotation. Source: Compara positive regulation of potassium ion transport Inferred from electronic annotation. Source: Compara positive regulation of protein dephosphorylation Inferred from electronic annotation. Source: Compara protein targeting to membrane Inferred from electronic annotation. Source: Compara regulation of excitatory postsynaptic membrane potential Inferred from electronic annotation. Source: Compara regulation of glomerular filtration Inferred from electronic annotation. Source: Compara regulation of respiratory gaseous exchange by neurological system process Inferred from electronic annotation. Source: Compara regulation of synaptic plasticity Inferred from electronic annotation. Source: Compara relaxation of vascular smooth muscle Inferred from electronic annotation. Source: Compara response to hypoxia Inferred from electronic annotation. Source: Compara temperature homeostasis Inferred from electronic annotation. Source: Compara
Cellular_component	asymmetric synapse Inferred from electronic annotation. Source: Compara axolemma Inferred from electronic annotation. Source: Compara basolateral plasma membrane Inferred from electronic annotation. Source: Compara endomembrane system Inferred from electronic annotation. Source: Compara endoplasmic reticulum Inferred from electronic annotation. Source: Compara integral to plasma membrane Traceable author statement Ref.1. Source: ProtInc neuronal cell body Inferred from electronic annotation. Source: Compara postsynaptic density Inferred from electronic annotation. Source: Compara postsynaptic membrane Inferred from electronic annotation. Source: Compara presynaptic active zone Inferred from electronic annotation. Source: Compara presynaptic membrane Inferred from electronic annotation. Source: Compara terminal bouton Inferred from electronic annotation. Source: Compara
Molecular_function	G-protein coupled adenosine receptor activity Inferred from electronic annotation. Source: InterPro phospholipase C activity Inferred from electronic annotation. Source: Compara purine nucleoside binding Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
ADORA2A	P29274	4	EBI-2903663,EBI-2902702

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: P30542-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: P30542-2)

The sequence of this isoform differs from the canonical sequence as follows:
     115-125: YKMVVTPRRAA → RISQCMASTKS
     126-326: Missing.

Note: Gene prediction based on EST data.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 326	326	Adenosine receptor A1		PRO_0000068991
Regions
	Topological domain	1 – 10	10	Extracellular Potential
	Transmembrane	11 – 33	23	Helical; Name=1; Potential
	Topological domain	34 – 46	13	Cytoplasmic Potential
	Transmembrane	47 – 69	23	Helical; Name=2; Potential
	Topological domain	70 – 80	11	Extracellular Potential
	Transmembrane	81 – 102	22	Helical; Name=3; Potential
	Topological domain	103 – 123	21	Cytoplasmic Potential
	Transmembrane	124 – 146	23	Helical; Name=4; Potential
	Topological domain	147 – 176	30	Extracellular Potential
	Transmembrane	177 – 201	25	Helical; Name=5; Potential
	Topological domain	202 – 235	34	Cytoplasmic Potential
	Transmembrane	236 – 259	24	Helical; Name=6; Potential
	Topological domain	260 – 267	8	Extracellular Potential
	Transmembrane	268 – 292	25	Helical; Name=7; Potential
	Topological domain	293 – 326	34	Cytoplasmic Potential
Amino acid modifications
	Lipidation	309	1	S-palmitoyl cysteine Potential
	Glycosylation	159	1	N-linked (GlcNAc...) Potential
	Disulfide bond	80 ↔ 169		By similarity
Natural variations
	Alternative sequence	115 – 125	11	YKMVVTPRRAA → RISQCMASTKS in isoform 2.		VSP_034401
	Alternative sequence	126 – 326	201	Missing in isoform 2.		VSP_034402
	Natural variant	43	1	A → S. Ref.12 Corresponds to variant rs11547175 [ dbSNP | Ensembl ].		VAR_044138
	Natural variant	50	1	S → P. Ref.12 Corresponds to variant rs11547174 [ dbSNP | Ensembl ].		VAR_044139
	Natural variant	105	1	R → H. Ref.12 Corresponds to variant rs11547176 [ dbSNP | Ensembl ].		VAR_044140
	Natural variant	170	1	E → K in a colorectal cancer sample; somatic mutation. Ref.13		VAR_035754
	Natural variant	261	1	P → Q. Ref.12 Corresponds to variant rs17852405 [ dbSNP | Ensembl ].		VAR_044141
Experimental info
	Sequence conflict	312	1	A → T in BAF82617. Ref.6

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified April 1, 1993. Version 1. Checksum: 1B555893BCDEC9A6	FASTA	326	36,512
	10 20 30 40 50 60 MPPSISAFQA AYIGIEVLIA LVSVPGNVLV IWAVKVNQAL RDATFCFIVS LAVADVAVGA 70 80 90 100 110 120 LVIPLAILIN IGPQTYFHTC LMVACPVLIL TQSSILALLA IAVDRYLRVK IPLRYKMVVT 130 140 150 160 170 180 PRRAAVAIAG CWILSFVVGL TPMFGWNNLS AVERAWAANG SMGEPVIKCE FEKVISMEYM 190 200 210 220 230 240 VYFNFFVWVL PPLLLMVLIY LEVFYLIRKQ LNKKVSASSG DPQKYYGKEL KIAKSLALIL 250 260 270 280 290 300 FLFALSWLPL HILNCITLFC PSCHKPSILT YIAIFLTHGN SAMNPIVYAF RIQKFRVTFL 310 320 KIWNDHFRCQ PAPPIDEDLP EERPDD
	Isoform 2 [UniParc]. Checksum: 37CB91365D17A5F5	FASTA	125	13,348
	10 20 30 40 50 60 MPPSISAFQA AYIGIEVLIA LVSVPGNVLV IWAVKVNQAL RDATFCFIVS LAVADVAVGA 70 80 90 100 110 120 LVIPLAILIN IGPQTYFHTC LMVACPVLIL TQSSILALLA IAVDRYLRVK IPLRRISQCM ASTKS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and functional characterization of a human A1 adenosine receptor." Libert F., van Sande J., Lefort A., Czernilofsky A., Dumont J.E., Vassart G., Ensinger H.A., Mendla K.D. Biochem. Biophys. Res. Commun. 187:919-926(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Hippocampus.
[2]	"Molecular cloning and characterisation of a human brain A1 adenosine receptor cDNA." Townsend-Nicholson A., Shine J. Brain Res. Mol. Brain Res. 16:365-370(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Brain.
[3]	"Characterization of the human A1 adenosine receptor gene. Evidence for alternative splicing." Ren H., Stiles G.L. J. Biol. Chem. 269:3104-3110(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Hippocampus.
[4]	Salvatore C.A., Luneau C.J., Johnson R.G., Jacobson M. Submitted (SEP-1992) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Brain.
[5]	"Complete nucleotide sequence of an adenosine A1-receptor from heart." Hirabatake Y., Takao K., Hagiwara S., Kasanuki H., Hosoda S., Kokubun S. Submitted (JUN-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Heart.
[6]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Brain and Hippocampus.
[7]	"cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)." Puhl H.L. III, Ikeda S.R., Aronstam R.S. Submitted (JUL-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Brain.
[8]	"Cloning of human full-length CDSs in BD Creator(TM) system donor vector." Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A. Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[9]	"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)." Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B. Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[10]	"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[11]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[12]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS SER-43; PRO-50; HIS-105 AND GLN-261. Tissue: Brain.
[13]	"The consensus coding sequences of human breast and colorectal cancers." Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E. Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT [LARGE SCALE ANALYSIS] LYS-170.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	S45235 mRNA. Translation: AAB23388.1. S56143 mRNA. Translation: AAB25533.2. L22214 mRNA. Translation: AAA17544.1. X68485 mRNA. Translation: CAA48503.1. AB004662 mRNA. Translation: BAA20433.1. AK127752 mRNA. Translation: BAG54566.1. AK289928 mRNA. Translation: BAF82617.1. AY136746 mRNA. Translation: AAN01272.1. BT019854 mRNA. Translation: AAV38657.1. CR541749 mRNA. Translation: CAG46549.1. AC105940 Genomic DNA. No translation available. CH471067 Genomic DNA. Translation: EAW91465.1. BC026340 mRNA. Translation: AAH26340.1.
IPI	IPI00026872. IPI00645335.
PIR	A53005.
RefSeq	NP_000665.1. NM_000674.2. NP_001041695.1. NM_001048230.1.
UniGene	Hs.77867.
3D structure databases
ProteinModelPortal	P30542.
ModBase	Search...
Protein-protein interaction databases
IntAct	P30542. 2 interactions.
MINT	MINT-138736.
STRING	9606.ENSP00000308549.
Protein family/group databases
GPCRDB	Search...
PTM databases
PhosphoSite	P30542.
Polymorphism databases
DMDM	231473.
Proteomic databases
PaxDb	P30542.
PRIDE	P30542.
Protocols and materials databases
DNASU	134.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000309502; ENSP00000308549; ENSG00000163485. ENST00000337894; ENSP00000338435; ENSG00000163485. ENST00000367235; ENSP00000356204; ENSG00000163485. ENST00000367236; ENSP00000356205; ENSG00000163485.
GeneID	134.
KEGG	hsa:134.
UCSC	uc001gze.1. human.
Organism-specific databases
CTD	134.
GeneCards	GC01P203059.
HGNC	HGNC:262. ADORA1.
MIM	102775. gene.
neXtProt	NX_P30542.
PharmGKB	PA24583.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG284456.
HOVERGEN	HBG106962.
InParanoid	P30542.
KO	K04265.
OMA	IPLRYKM.
OrthoDB	EOG4BVRV7.
PhylomeDB	P30542.
Enzyme and pathway databases
Reactome	REACT_111102. Signal Transduction.
Gene expression databases
ArrayExpress	P30542.
Bgee	P30542.
CleanEx	HS_ADORA1.
Genevestigator	P30542.
GermOnline	ENSG00000163485. Homo sapiens.
Family and domain databases
InterPro	IPR001068. Adeno_A1_rcpt. IPR001634. Adenosn_rcpt. IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. [Graphical view]
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR00552. ADENOSINEA1R. PR00424. ADENOSINER. PR00237. GPCRRHODOPSN.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
BindingDB	P30542.
ChEMBL	CHEMBL226.
ChiTaRS	ADORA1. human.
DrugBank	DB01223. Aminophylline. DB00201. Caffeine. DB04932. Defibrotide. DB00996. Gabapentin. DB00458. Imipramine. DB00061. Pegademase bovine. DB00277. Theophylline.
GenomeRNAi	134.
NextBio	537.
SOURCE	Search...

Entry information

Entry name

AA1R_HUMAN

Accession

Primary (citable) accession number: P30542
Secondary accession number(s): A6NFY5 , A6NGP4, A8K1L3, B3KXQ4, Q6FHK3, Q8TAM8

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 1, 1993
Last sequence update:	April 1, 1993
Last modified:	May 1, 2013
This is version 125 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.