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P30542 (AA1R_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 135. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Adenosine receptor A1
Gene names
Name:ADORA1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length326 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
   Cellular componentCell membrane
Membrane
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainTransmembrane
Transmembrane helix
   Molecular functionG-protein coupled receptor
Receptor
Transducer
   PTMDisulfide bond
Glycoprotein
Lipoprotein
Palmitate
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processactivation of MAPKK activity

Inferred from electronic annotation. Source: Ensembl

adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway

Inferred from electronic annotation. Source: Ensembl

apoptotic signaling pathway

Traceable author statement PubMed 7818494. Source: ProtInc

cell-cell signaling

Traceable author statement PubMed 7818494. Source: ProtInc

cognition

Inferred from electronic annotation. Source: Ensembl

detection of temperature stimulus involved in sensory perception of pain

Inferred from electronic annotation. Source: Ensembl

inflammatory response

Traceable author statement PubMed 8360491. Source: ProtInc

lipid catabolic process

Inferred from electronic annotation. Source: Ensembl

negative regulation of acute inflammatory response

Inferred from electronic annotation. Source: Ensembl

negative regulation of apoptotic process

Inferred from electronic annotation. Source: Ensembl

negative regulation of blood pressure

Inferred from electronic annotation. Source: Ensembl

negative regulation of cardiac muscle contraction

Inferred from electronic annotation. Source: Ensembl

negative regulation of cell proliferation

Inferred from electronic annotation. Source: Ensembl

negative regulation of circadian sleep/wake cycle, non-REM sleep

Inferred from electronic annotation. Source: Ensembl

negative regulation of glutamate secretion

Inferred from electronic annotation. Source: Ensembl

negative regulation of heart contraction

Inferred from electronic annotation. Source: Ensembl

negative regulation of hormone secretion

Inferred from electronic annotation. Source: Ensembl

negative regulation of leukocyte migration

Inferred from electronic annotation. Source: Ensembl

negative regulation of lipid catabolic process

Inferred from electronic annotation. Source: Ensembl

negative regulation of mucus secretion

Inferred from electronic annotation. Source: Ensembl

negative regulation of neurotrophin production

Inferred from electronic annotation. Source: Ensembl

negative regulation of renal sodium excretion

Inferred from electronic annotation. Source: Ensembl

negative regulation of synaptic transmission, GABAergic

Inferred from electronic annotation. Source: Ensembl

negative regulation of synaptic transmission, glutamatergic

Inferred from electronic annotation. Source: Ensembl

negative regulation of vasodilation

Inferred from electronic annotation. Source: Ensembl

nervous system development

Traceable author statement PubMed 8450977. Source: ProtInc

phagocytosis

Traceable author statement PubMed 8360491. Source: ProtInc

positive regulation of blood pressure

Inferred from electronic annotation. Source: Ensembl

positive regulation of epidermal growth factor-activated receptor activity

Inferred from electronic annotation. Source: Ensembl

positive regulation of nucleoside transport

Inferred from electronic annotation. Source: Ensembl

positive regulation of peptide secretion

Inferred from electronic annotation. Source: Ensembl

positive regulation of potassium ion transport

Inferred from electronic annotation. Source: Ensembl

positive regulation of protein dephosphorylation

Inferred from electronic annotation. Source: Ensembl

protein targeting to membrane

Inferred from electronic annotation. Source: Ensembl

regulation of excitatory postsynaptic membrane potential

Inferred from electronic annotation. Source: Ensembl

regulation of glomerular filtration

Inferred from electronic annotation. Source: Ensembl

regulation of respiratory gaseous exchange by neurological system process

Inferred from electronic annotation. Source: Ensembl

regulation of synaptic plasticity

Inferred from electronic annotation. Source: Ensembl

relaxation of vascular smooth muscle

Inferred from electronic annotation. Source: Ensembl

response to hypoxia

Inferred from electronic annotation. Source: Ensembl

signal transduction

Traceable author statement Ref.1. Source: ProtInc

temperature homeostasis

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentasymmetric synapse

Inferred from electronic annotation. Source: Ensembl

axolemma

Inferred from electronic annotation. Source: Ensembl

basolateral plasma membrane

Inferred from electronic annotation. Source: Ensembl

dendrite

Inferred from electronic annotation. Source: Ensembl

endoplasmic reticulum

Inferred from electronic annotation. Source: Ensembl

integral component of plasma membrane

Traceable author statement Ref.1. Source: ProtInc

neuronal cell body

Inferred from electronic annotation. Source: Ensembl

plasma membrane

Traceable author statement. Source: Reactome

postsynaptic density

Inferred from electronic annotation. Source: Ensembl

postsynaptic membrane

Inferred from electronic annotation. Source: Ensembl

presynaptic active zone

Inferred from electronic annotation. Source: Ensembl

presynaptic membrane

Inferred from electronic annotation. Source: Ensembl

terminal bouton

Inferred from electronic annotation. Source: Ensembl

   Molecular_functionG-protein coupled adenosine receptor activity

Inferred from electronic annotation. Source: InterPro

phospholipase C activity

Inferred from electronic annotation. Source: Ensembl

purine nucleoside binding

Inferred from electronic annotation. Source: Ensembl

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

ADORA2AP292744EBI-2903663,EBI-2902702

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: P30542-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: P30542-2)

The sequence of this isoform differs from the canonical sequence as follows:
     115-125: YKMVVTPRRAA → RISQCMASTKS
     126-326: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 326326Adenosine receptor A1
PRO_0000068991

Regions

Topological domain1 – 1010Extracellular Potential
Transmembrane11 – 3323Helical; Name=1; Potential
Topological domain34 – 4613Cytoplasmic Potential
Transmembrane47 – 6923Helical; Name=2; Potential
Topological domain70 – 8011Extracellular Potential
Transmembrane81 – 10222Helical; Name=3; Potential
Topological domain103 – 12321Cytoplasmic Potential
Transmembrane124 – 14623Helical; Name=4; Potential
Topological domain147 – 17630Extracellular Potential
Transmembrane177 – 20125Helical; Name=5; Potential
Topological domain202 – 23534Cytoplasmic Potential
Transmembrane236 – 25924Helical; Name=6; Potential
Topological domain260 – 2678Extracellular Potential
Transmembrane268 – 29225Helical; Name=7; Potential
Topological domain293 – 32634Cytoplasmic Potential

Amino acid modifications

Lipidation3091S-palmitoyl cysteine Potential
Glycosylation1591N-linked (GlcNAc...) Potential
Disulfide bond80 ↔ 169 By similarity

Natural variations

Alternative sequence115 – 12511YKMVVTPRRAA → RISQCMASTKS in isoform 2.
VSP_034401
Alternative sequence126 – 326201Missing in isoform 2.
VSP_034402
Natural variant431A → S. Ref.13
Corresponds to variant rs11547175 [ dbSNP | Ensembl ].
VAR_044138
Natural variant501S → P. Ref.13
Corresponds to variant rs11547174 [ dbSNP | Ensembl ].
VAR_044139
Natural variant1051R → H. Ref.13
Corresponds to variant rs11547176 [ dbSNP | Ensembl ].
VAR_044140
Natural variant1701E → K in a colorectal cancer sample; somatic mutation. Ref.14
VAR_035754
Natural variant2611P → Q. Ref.13
Corresponds to variant rs17852405 [ dbSNP | Ensembl ].
VAR_044141

Experimental info

Sequence conflict3121A → T in BAF82617. Ref.7

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified April 1, 1993. Version 1.
Checksum: 1B555893BCDEC9A6

FASTA32636,512
        10         20         30         40         50         60 
MPPSISAFQA AYIGIEVLIA LVSVPGNVLV IWAVKVNQAL RDATFCFIVS LAVADVAVGA 

        70         80         90        100        110        120 
LVIPLAILIN IGPQTYFHTC LMVACPVLIL TQSSILALLA IAVDRYLRVK IPLRYKMVVT 

       130        140        150        160        170        180 
PRRAAVAIAG CWILSFVVGL TPMFGWNNLS AVERAWAANG SMGEPVIKCE FEKVISMEYM 

       190        200        210        220        230        240 
VYFNFFVWVL PPLLLMVLIY LEVFYLIRKQ LNKKVSASSG DPQKYYGKEL KIAKSLALIL 

       250        260        270        280        290        300 
FLFALSWLPL HILNCITLFC PSCHKPSILT YIAIFLTHGN SAMNPIVYAF RIQKFRVTFL 

       310        320 
KIWNDHFRCQ PAPPIDEDLP EERPDD 

« Hide

Isoform 2 [UniParc].

Checksum: 37CB91365D17A5F5
Show »

FASTA12513,348

References

« Hide 'large scale' references
[1]"Cloning and functional characterization of a human A1 adenosine receptor."
Libert F., van Sande J., Lefort A., Czernilofsky A., Dumont J.E., Vassart G., Ensinger H.A., Mendla K.D.
Biochem. Biophys. Res. Commun. 187:919-926(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
Tissue: Hippocampus.
[2]"Molecular cloning and characterisation of a human brain A1 adenosine receptor cDNA."
Townsend-Nicholson A., Shine J.
Brain Res. Mol. Brain Res. 16:365-370(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
Tissue: Brain.
[3]"Characterization of the human A1 adenosine receptor gene. Evidence for alternative splicing."
Ren H., Stiles G.L.
J. Biol. Chem. 269:3104-3110(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
Tissue: Hippocampus.
[4]Salvatore C.A., Luneau C.J., Johnson R.G., Jacobson M.
Submitted (SEP-1992) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
Tissue: Brain.
[5]"Complete nucleotide sequence of an adenosine A1-receptor from heart."
Hirabatake Y., Takao K., Hagiwara S., Kasanuki H., Hosoda S., Kokubun S.
Submitted (JUN-1997) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
Tissue: Heart.
[6]"Identification of a 3TM adenosine receptor subtype 1 variant."
Feng Y.-H., Cheng H., Qiu R.
Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
[7]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Brain and Hippocampus.
[8]"cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
Puhl H.L. III, Ikeda S.R., Aronstam R.S.
Submitted (JUL-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Brain.
[9]"Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[10]"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[11]"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. expand/collapse author list , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[12]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[13]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS SER-43; PRO-50; HIS-105 AND GLN-261.
Tissue: Brain.
[14]"The consensus coding sequences of human breast and colorectal cancers."
Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. expand/collapse author list , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E.
Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT [LARGE SCALE ANALYSIS] LYS-170.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
S45235 mRNA. Translation: AAB23388.1.
S56143 mRNA. Translation: AAB25533.2.
L22214 mRNA. Translation: AAA17544.1.
X68485 mRNA. Translation: CAA48503.1.
AB004662 mRNA. Translation: BAA20433.1.
EF057066 mRNA. Translation: ABO25743.1.
AK127752 mRNA. Translation: BAG54566.1.
AK289928 mRNA. Translation: BAF82617.1.
AY136746 mRNA. Translation: AAN01272.1.
BT019854 mRNA. Translation: AAV38657.1.
CR541749 mRNA. Translation: CAG46549.1.
AC105940 Genomic DNA. No translation available.
CH471067 Genomic DNA. Translation: EAW91465.1.
BC026340 mRNA. Translation: AAH26340.1.
PIRA53005.
RefSeqNP_000665.1. NM_000674.2.
NP_001041695.1. NM_001048230.1.
UniGeneHs.77867.

3D structure databases

ProteinModelPortalP30542.
SMRP30542. Positions 10-306.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid106646. 7 interactions.
IntActP30542. 2 interactions.
MINTMINT-138736.
STRING9606.ENSP00000308549.

Chemistry

BindingDBP30542.
ChEMBLCHEMBL2096908.
DrugBankDB01223. Aminophylline.
DB00201. Caffeine.
DB04932. Defibrotide.
DB00996. Gabapentin.
DB00458. Imipramine.
DB00061. Pegademase bovine.
DB00277. Theophylline.
GuidetoPHARMACOLOGY18.

Protein family/group databases

TCDB9.A.14.3.4. the g-protein-coupled receptor (gpcr) family.
GPCRDBSearch...

PTM databases

PhosphoSiteP30542.

Polymorphism databases

DMDM231473.

Proteomic databases

PaxDbP30542.
PRIDEP30542.

Protocols and materials databases

DNASU134.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000309502; ENSP00000308549; ENSG00000163485. [P30542-1]
ENST00000337894; ENSP00000338435; ENSG00000163485. [P30542-1]
ENST00000367235; ENSP00000356204; ENSG00000163485. [P30542-2]
ENST00000367236; ENSP00000356205; ENSG00000163485. [P30542-1]
GeneID134.
KEGGhsa:134.
UCSCuc001gze.1. human. [P30542-1]

Organism-specific databases

CTD134.
GeneCardsGC01P203059.
HGNCHGNC:262. ADORA1.
MIM102775. gene.
neXtProtNX_P30542.
PharmGKBPA24583.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG284456.
HOVERGENHBG106962.
InParanoidP30542.
KOK04265.
OMAIPLRYKM.
OrthoDBEOG79SDXQ.
PhylomeDBP30542.
TreeFamTF325296.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

ArrayExpressP30542.
BgeeP30542.
CleanExHS_ADORA1.
GenevestigatorP30542.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR001068. Adeno_A1_rcpt.
IPR001634. Adenosn_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00552. ADENOSINEA1R.
PR00424. ADENOSINER.
PR00237. GPCRRHODOPSN.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSADORA1. human.
GeneWikiAdenosine_A1_receptor.
GenomeRNAi134.
NextBio537.
PROP30542.
SOURCESearch...

Entry information

Entry nameAA1R_HUMAN
AccessionPrimary (citable) accession number: P30542
Secondary accession number(s): A6NFY5 expand/collapse secondary AC list , A6NGP4, A8K1L3, B3KXQ4, D2CGD0, Q6FHK3, Q8TAM8
Entry history
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: April 16, 2014
This is version 135 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries