Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Translocator protein

Gene

TSPO

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Can bind protoporphyrin IX and may play a role in the transport of porphyrins and heme (By similarity). Promotes the transport of cholesterol across mitochondrial membranes and may play a role in lipid metabolism (PubMed:24814875), but its precise physiological role is controversial. It is apparently not required for steroid hormone biosynthesis. Was initially identified as peripheral-type benzodiazepine receptor; can also bind isoquinoline carboxamides (PubMed:1847678).By similarity2 Publications

GO - Molecular functioni

  • androgen binding Source: Ensembl
  • benzodiazepine receptor activity Source: ProtInc
  • cholesterol binding Source: HGNC

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Lipid transport, Transport

Enzyme and pathway databases

BioCyciZFISH:ENSG00000100300-MONOMER.

Protein family/group databases

TCDBi9.A.24.1.1. the mitochondrial cholesterol/porphyrin uptake translocator protein (tspo) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Translocator protein
Alternative name(s):
Mitochondrial benzodiazepine receptor
PKBS
Peripheral-type benzodiazepine receptor
Short name:
PBR
Gene namesi
Name:TSPO
Synonyms:BZRP, MBR
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

HGNCiHGNC:1158. TSPO.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini2 – 5Mitochondrial intermembraneBy similarity4
Transmembranei6 – 26Helical; Name=1By similarityAdd BLAST21
Topological domaini27 – 46CytoplasmicBy similarityAdd BLAST20
Transmembranei47 – 67Helical; Name=2By similarityAdd BLAST21
Topological domaini68 – 79Mitochondrial intermembraneBy similarityAdd BLAST12
Transmembranei80 – 100Helical; Name=3By similarityAdd BLAST21
Topological domaini101 – 105CytoplasmicBy similarity5
Transmembranei106 – 126Helical; Name=4By similarityAdd BLAST21
Topological domaini127 – 134Mitochondrial intermembraneBy similarity8
Transmembranei135 – 155Helical; Name=5By similarityAdd BLAST21
Topological domaini156 – 169CytoplasmicBy similarityAdd BLAST14

GO - Cellular componenti

  • cytoplasm Source: HPA
  • extracellular exosome Source: UniProtKB
  • integral component of membrane Source: UniProtKB-KW
  • intracellular membrane-bounded organelle Source: HPA
  • mitochondrial outer membrane Source: ProtInc
  • mitochondrion Source: HPA
  • nuclear membrane Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion

Pathology & Biotechi

Organism-specific databases

DisGeNETi706.
OpenTargetsiENSG00000100300.
PharmGKBiPA25473.

Chemistry databases

ChEMBLiCHEMBL5742.
DrugBankiDB01178. Chlormezanone.
DB01068. Clonazepam.
DB00628. Clorazepate.
DB00829. Diazepam.
DB00402. Eszopiclone.
DB01544. Flunitrazepam.
DB01587. Ketazolam.
DB00186. Lorazepam.
DB00231. Temazepam.
DB00897. Triazolam.
DB00962. Zaleplon.
DB01198. Zopiclone.
GuidetoPHARMACOLOGYi2879.

Polymorphism and mutation databases

BioMutaiTSPO.
DMDMi313104268.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00001909972 – 169Translocator proteinAdd BLAST168

Proteomic databases

EPDiP30536.
MaxQBiP30536.
PaxDbiP30536.
PeptideAtlasiP30536.
PRIDEiP30536.
TopDownProteomicsiP30536-1. [P30536-1]

PTM databases

iPTMnetiP30536.
PhosphoSitePlusiP30536.
SwissPalmiP30536.

Expressioni

Tissue specificityi

Found in many tissue types. Expressed at the highest levels under normal conditions in tissues that synthesize steroids.1 Publication

Gene expression databases

BgeeiENSG00000100300.
CleanExiHS_TSPO.
ExpressionAtlasiP30536. baseline and differential.
GenevisibleiP30536. HS.

Organism-specific databases

HPAiCAB011232.
HPA046260.

Interactioni

Subunit structurei

Interacts with TSPOAP1 (By similarity). May interact with STAR (By similarity). Interacts with MOST-1.By similarity2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
CREB3L1Q96BA83EBI-6623146,EBI-6942903

Protein-protein interaction databases

BioGridi107168. 16 interactors.
IntActiP30536. 1 interactor.
STRINGi9606.ENSP00000328973.

Chemistry databases

BindingDBiP30536.

Structurei

3D structure databases

ProteinModelPortaliP30536.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TspO/BZRP family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3797. Eukaryota.
COG3476. LUCA.
GeneTreeiENSGT00390000012980.
HOGENOMiHOG000224659.
InParanoidiP30536.
KOiK05770.
OMAiNPPDWLF.
OrthoDBiEOG091G0W79.
PhylomeDBiP30536.
TreeFamiTF342852.

Family and domain databases

InterProiIPR030164. TSPO.
IPR004307. TspO_MBR.
[Graphical view]
PANTHERiPTHR10057. PTHR10057. 1 hit.
PTHR10057:SF5. PTHR10057:SF5. 1 hit.
PfamiPF03073. TspO_MBR. 1 hit.
[Graphical view]
PIRSFiPIRSF005859. PBR. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P30536-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAPPWVPAMG FTLAPSLGCF VGSRFVHGEG LRWYAGLQKP SWHPPHWVLG
60 70 80 90 100
PVWGTLYSAM GYGSYLVWKE LGGFTEKAVV PLGLYTGQLA LNWAWPPIFF
110 120 130 140 150
GARQMGWALV DLLLVSGAAA ATTVAWYQVS PLAARLLYPY LAWLAFTTTL
160
NYCVWRDNHG WRGGRRLPE
Length:169
Mass (Da):18,828
Last modified:November 30, 2010 - v3
Checksum:i6DD741BF99AB89D9
GO
Isoform 2 (identifier: B1AH88-1) [UniParc]FASTAAdd to basket
Also known as: PBR-S
The sequence of this isoform can be found in the external entry B1AH88.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Note: No experimental confirmation available. The relatively low levels of the corresponding mRNA suggest that it might represent errors of the splicing machinery. In addition, isoform 2 is derived from a different reading frame, compared to isoform 1 and lacks homolog support.
Length:102
Mass (Da):10,537
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_013617147T → A Associated with higher levels of pregnenolone production by lymphomonocytes and with increased plasma levels of cholesterol-rich low density lipoprotein. 7 PublicationsCorresponds to variant rs6971dbSNPEnsembl.1
Natural variantiVAR_013618162R → H.5 PublicationsCorresponds to variant rs6972dbSNPEnsembl.1
Natural variantiVAR_018868169E → Q.1 PublicationCorresponds to variant rs9333342dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M36035 mRNA. Translation: AAA03652.1.
U12421 Genomic DNA. Translation: AAA83252.1.
AY998017 mRNA. Translation: AAY45787.1.
BT006949 mRNA. Translation: AAP35595.1.
CR456409 mRNA. Translation: CAG30295.1.
AY383615 Genomic DNA. Translation: AAQ75703.1.
Z82214 Genomic DNA. Translation: CAB55884.1.
BC001110 mRNA. Translation: AAH01110.1.
CCDSiCCDS33661.1. [P30536-1]
PIRiI38724.
JE0149.
S14257.
RefSeqiNP_000705.2. NM_000714.5. [P30536-1]
NP_001243459.1. NM_001256530.1. [P30536-1]
NP_001243460.1. NM_001256531.1. [P30536-1]
UniGeneiHs.202.

Genome annotation databases

EnsembliENST00000329563; ENSP00000328973; ENSG00000100300. [P30536-1]
ENST00000337554; ENSP00000338004; ENSG00000100300. [P30536-1]
ENST00000396265; ENSP00000379563; ENSG00000100300. [P30536-1]
GeneIDi706.
KEGGihsa:706.
UCSCiuc003bdn.4. human. [P30536-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M36035 mRNA. Translation: AAA03652.1.
U12421 Genomic DNA. Translation: AAA83252.1.
AY998017 mRNA. Translation: AAY45787.1.
BT006949 mRNA. Translation: AAP35595.1.
CR456409 mRNA. Translation: CAG30295.1.
AY383615 Genomic DNA. Translation: AAQ75703.1.
Z82214 Genomic DNA. Translation: CAB55884.1.
BC001110 mRNA. Translation: AAH01110.1.
CCDSiCCDS33661.1. [P30536-1]
PIRiI38724.
JE0149.
S14257.
RefSeqiNP_000705.2. NM_000714.5. [P30536-1]
NP_001243459.1. NM_001256530.1. [P30536-1]
NP_001243460.1. NM_001256531.1. [P30536-1]
UniGeneiHs.202.

3D structure databases

ProteinModelPortaliP30536.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107168. 16 interactors.
IntActiP30536. 1 interactor.
STRINGi9606.ENSP00000328973.

Chemistry databases

BindingDBiP30536.
ChEMBLiCHEMBL5742.
DrugBankiDB01178. Chlormezanone.
DB01068. Clonazepam.
DB00628. Clorazepate.
DB00829. Diazepam.
DB00402. Eszopiclone.
DB01544. Flunitrazepam.
DB01587. Ketazolam.
DB00186. Lorazepam.
DB00231. Temazepam.
DB00897. Triazolam.
DB00962. Zaleplon.
DB01198. Zopiclone.
GuidetoPHARMACOLOGYi2879.

Protein family/group databases

TCDBi9.A.24.1.1. the mitochondrial cholesterol/porphyrin uptake translocator protein (tspo) family.

PTM databases

iPTMnetiP30536.
PhosphoSitePlusiP30536.
SwissPalmiP30536.

Polymorphism and mutation databases

BioMutaiTSPO.
DMDMi313104268.

Proteomic databases

EPDiP30536.
MaxQBiP30536.
PaxDbiP30536.
PeptideAtlasiP30536.
PRIDEiP30536.
TopDownProteomicsiP30536-1. [P30536-1]

Protocols and materials databases

DNASUi706.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000329563; ENSP00000328973; ENSG00000100300. [P30536-1]
ENST00000337554; ENSP00000338004; ENSG00000100300. [P30536-1]
ENST00000396265; ENSP00000379563; ENSG00000100300. [P30536-1]
GeneIDi706.
KEGGihsa:706.
UCSCiuc003bdn.4. human. [P30536-1]

Organism-specific databases

CTDi706.
DisGeNETi706.
GeneCardsiTSPO.
HGNCiHGNC:1158. TSPO.
HPAiCAB011232.
HPA046260.
MIMi109610. gene.
neXtProtiNX_P30536.
OpenTargetsiENSG00000100300.
PharmGKBiPA25473.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3797. Eukaryota.
COG3476. LUCA.
GeneTreeiENSGT00390000012980.
HOGENOMiHOG000224659.
InParanoidiP30536.
KOiK05770.
OMAiNPPDWLF.
OrthoDBiEOG091G0W79.
PhylomeDBiP30536.
TreeFamiTF342852.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000100300-MONOMER.

Miscellaneous databases

ChiTaRSiTSPO. human.
GeneWikiiTranslocator_protein.
GenomeRNAii706.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000100300.
CleanExiHS_TSPO.
ExpressionAtlasiP30536. baseline and differential.
GenevisibleiP30536. HS.

Family and domain databases

InterProiIPR030164. TSPO.
IPR004307. TspO_MBR.
[Graphical view]
PANTHERiPTHR10057. PTHR10057. 1 hit.
PTHR10057:SF5. PTHR10057:SF5. 1 hit.
PfamiPF03073. TspO_MBR. 1 hit.
[Graphical view]
PIRSFiPIRSF005859. PBR. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiTSPO_HUMAN
AccessioniPrimary (citable) accession number: P30536
Secondary accession number(s): Q53Y59, Q6ICF9, Q96TF6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: November 30, 2010
Last modified: November 2, 2016
This is version 154 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.