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P30536

- TSPOA_HUMAN

UniProt

P30536 - TSPOA_HUMAN

Protein

Translocator protein

Gene

TSPO

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Can bind protoporphyrin IX and may play a role in the transport of porphyrins and heme By similarity. Promotes the transport of cholesterol across mitochondrial membranes and may play a role in lipid metabolism (PubMed:24814875), but its precise physiological role is controversial. It is apparently not required for steroid hormone biosynthesis. Was initially identified as peripheral-type benzodiazepine receptor; can also bind isoquinoline carboxamides(PubMed:1847678).By similarity2 Publications

    GO - Molecular functioni

    1. androgen binding Source: Ensembl
    2. benzodiazepine receptor activity Source: ProtInc
    3. cholesterol binding Source: HGNC

    GO - Biological processi

    1. adrenal gland development Source: Ensembl
    2. aging Source: Ensembl
    3. anion transport Source: HGNC
    4. apoptotic process Source: HGNC
    5. behavioral response to pain Source: Ensembl
    6. cell proliferation Source: HGNC
    7. cellular hypotonic response Source: Ensembl
    8. cellular response to lipopolysaccharide Source: Ensembl
    9. cellular response to zinc ion Source: Ensembl
    10. chloride transport Source: Ensembl
    11. contact inhibition Source: Ensembl
    12. glial cell migration Source: Ensembl
    13. heme biosynthetic process Source: HGNC
    14. negative regulation of glial cell proliferation Source: Ensembl
    15. negative regulation of nitric oxide biosynthetic process Source: Ensembl
    16. negative regulation of tumor necrosis factor production Source: Ensembl
    17. peripheral nervous system axon regeneration Source: Ensembl
    18. positive regulation of apoptotic process Source: Ensembl
    19. positive regulation of calcium ion transport Source: Ensembl
    20. positive regulation of glial cell proliferation Source: Ensembl
    21. positive regulation of mitochondrial depolarization Source: Ensembl
    22. positive regulation of necrotic cell death Source: Ensembl
    23. positive regulation of reactive oxygen species metabolic process Source: Ensembl
    24. protein targeting to mitochondrion Source: ProtInc
    25. regulation of cholesterol transport Source: HGNC
    26. regulation of steroid biosynthetic process Source: Ensembl
    27. response to drug Source: Ensembl
    28. response to manganese ion Source: Ensembl
    29. response to progesterone Source: Ensembl
    30. response to testosterone Source: Ensembl
    31. response to vitamin B1 Source: Ensembl
    32. steroid biosynthetic process Source: Ensembl
    33. steroid metabolic process Source: HGNC
    34. synaptic transmission Source: GOC

    Keywords - Molecular functioni

    Receptor

    Keywords - Biological processi

    Lipid transport, Transport

    Protein family/group databases

    TCDBi9.A.24.1.1. the mitochondrial cholesterol/porphyrin uptake translocator protein (tspo) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Translocator protein
    Alternative name(s):
    Mitochondrial benzodiazepine receptor
    PKBS
    Peripheral-type benzodiazepine receptor
    Short name:
    PBR
    Gene namesi
    Name:TSPO
    Synonyms:BZRP, MBR
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 22

    Organism-specific databases

    HGNCiHGNC:1158. TSPO.

    Subcellular locationi

    Mitochondrion membrane 1 Publication; Multi-pass membrane protein 1 Publication

    GO - Cellular componenti

    1. cytoplasm Source: HPA
    2. extracellular vesicular exosome Source: UniProt
    3. integral component of membrane Source: UniProtKB-KW
    4. intracellular membrane-bounded organelle Source: HPA
    5. mitochondrial outer membrane Source: ProtInc
    6. mitochondrion Source: HPA
    7. nuclear membrane Source: HPA

    Keywords - Cellular componenti

    Membrane, Mitochondrion

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA25473.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 169169Translocator proteinPRO_0000190997Add
    BLAST

    Proteomic databases

    MaxQBiP30536.
    PaxDbiP30536.
    PRIDEiP30536.

    Expressioni

    Tissue specificityi

    Found in many tissue types. Expressed at the highest levels under normal conditions in tissues that synthesize steroids.1 Publication

    Gene expression databases

    ArrayExpressiP30536.
    BgeeiP30536.
    CleanExiHS_TSPO.
    GenevestigatoriP30536.

    Organism-specific databases

    HPAiCAB011232.
    HPA046260.

    Interactioni

    Subunit structurei

    Interacts with BZRAP1 By similarity. May interact with STAR By similarity. Interacts with MOST-1.By similarity2 Publications

    Protein-protein interaction databases

    BioGridi107168. 3 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliP30536.
    SMRiP30536. Positions 1-169.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 55Mitochondrial intermembraneBy similarity
    Topological domaini27 – 4620CytoplasmicBy similarityAdd
    BLAST
    Topological domaini68 – 7912Mitochondrial intermembraneBy similarityAdd
    BLAST
    Topological domaini101 – 1055CytoplasmicBy similarity
    Topological domaini127 – 1348Mitochondrial intermembraneBy similarity
    Topological domaini156 – 16914CytoplasmicBy similarityAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei6 – 2621Helical; Name=1By similarityAdd
    BLAST
    Transmembranei47 – 6721Helical; Name=2By similarityAdd
    BLAST
    Transmembranei80 – 10021Helical; Name=3By similarityAdd
    BLAST
    Transmembranei106 – 12621Helical; Name=4By similarityAdd
    BLAST
    Transmembranei135 – 15521Helical; Name=5By similarityAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the TspO/BZRP family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG3476.
    HOGENOMiHOG000224659.
    InParanoidiP30536.
    KOiK05770.
    OMAiALNYRIW.
    OrthoDBiEOG7V7687.
    PhylomeDBiP30536.
    TreeFamiTF342852.

    Family and domain databases

    InterProiIPR004307. TspO_MBR.
    [Graphical view]
    PANTHERiPTHR10057. PTHR10057. 1 hit.
    PfamiPF03073. TspO_MBR. 1 hit.
    [Graphical view]
    PIRSFiPIRSF005859. PBR. 1 hit.

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P30536-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAPPWVPAMG FTLAPSLGCF VGSRFVHGEG LRWYAGLQKP SWHPPHWVLG    50
    PVWGTLYSAM GYGSYLVWKE LGGFTEKAVV PLGLYTGQLA LNWAWPPIFF 100
    GARQMGWALV DLLLVSGAAA ATTVAWYQVS PLAARLLYPY LAWLAFTTTL 150
    NYCVWRDNHG WRGGRRLPE 169
    Length:169
    Mass (Da):18,828
    Last modified:November 30, 2010 - v3
    Checksum:i6DD741BF99AB89D9
    GO
    Isoform 2 (identifier: B1AH88-1) [UniParc]FASTAAdd to Basket

    Also known as: PBR-S

    The sequence of this isoform can be found in the external entry B1AH88.
    Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.

    Note: No experimental confirmation available. The relatively low levels of the corresponding mRNA suggest that it might represent errors of the splicing machinery. In addition, isoform 2 is derived from a different reading frame, compared to isoform 1 and lacks homolog support.

    Length:102
    Mass (Da):10,537
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti147 – 1471T → A Associated with higher levels of pregnenolone production by lymphomonocytes and with increased plasma levels of cholesterol-rich low density lipoprotein. 6 Publications
    Corresponds to variant rs6971 [ dbSNP | Ensembl ].
    VAR_013617
    Natural varianti162 – 1621R → H.5 Publications
    Corresponds to variant rs6972 [ dbSNP | Ensembl ].
    VAR_013618
    Natural varianti169 – 1691E → Q.1 Publication
    Corresponds to variant rs9333342 [ dbSNP | Ensembl ].
    VAR_018868

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M36035 mRNA. Translation: AAA03652.1.
    U12421 Genomic DNA. Translation: AAA83252.1.
    AY998017 mRNA. Translation: AAY45787.1.
    BT006949 mRNA. Translation: AAP35595.1.
    CR456409 mRNA. Translation: CAG30295.1.
    AY383615 Genomic DNA. Translation: AAQ75703.1.
    Z82214 Genomic DNA. Translation: CAB55884.1.
    BC001110 mRNA. Translation: AAH01110.1.
    CCDSiCCDS33661.1. [P30536-1]
    PIRiI38724.
    JE0149.
    S14257.
    RefSeqiNP_000705.2. NM_000714.5. [P30536-1]
    NP_001243459.1. NM_001256530.1. [P30536-1]
    NP_001243460.1. NM_001256531.1. [P30536-1]
    UniGeneiHs.202.

    Genome annotation databases

    EnsembliENST00000329563; ENSP00000328973; ENSG00000100300. [P30536-1]
    ENST00000337554; ENSP00000338004; ENSG00000100300. [P30536-1]
    GeneIDi706.
    KEGGihsa:706.
    UCSCiuc003bdn.4. human. [P30536-1]

    Polymorphism databases

    DMDMi313104268.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Web resourcesi

    NIEHS-SNPs

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M36035 mRNA. Translation: AAA03652.1 .
    U12421 Genomic DNA. Translation: AAA83252.1 .
    AY998017 mRNA. Translation: AAY45787.1 .
    BT006949 mRNA. Translation: AAP35595.1 .
    CR456409 mRNA. Translation: CAG30295.1 .
    AY383615 Genomic DNA. Translation: AAQ75703.1 .
    Z82214 Genomic DNA. Translation: CAB55884.1 .
    BC001110 mRNA. Translation: AAH01110.1 .
    CCDSi CCDS33661.1. [P30536-1 ]
    PIRi I38724.
    JE0149.
    S14257.
    RefSeqi NP_000705.2. NM_000714.5. [P30536-1 ]
    NP_001243459.1. NM_001256530.1. [P30536-1 ]
    NP_001243460.1. NM_001256531.1. [P30536-1 ]
    UniGenei Hs.202.

    3D structure databases

    ProteinModelPortali P30536.
    SMRi P30536. Positions 1-169.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 107168. 3 interactions.

    Chemistry

    BindingDBi P30536.
    ChEMBLi CHEMBL5742.
    DrugBanki DB00546. Adinazolam.
    DB00404. Alprazolam.
    DB01178. Chlormezanone.
    DB01594. Cinolazepam.
    DB01068. Clonazepam.
    DB00628. Clorazepate.
    DB01559. Clotiazepam.
    DB00829. Diazepam.
    DB00822. Disulfiram.
    DB01215. Estazolam.
    DB00402. Eszopiclone.
    DB01544. Flunitrazepam.
    DB00801. Halazepam.
    DB00186. Lorazepam.
    DB00231. Temazepam.
    DB00897. Triazolam.
    DB00962. Zaleplon.
    DB00425. Zolpidem.
    DB01198. Zopiclone.

    Protein family/group databases

    TCDBi 9.A.24.1.1. the mitochondrial cholesterol/porphyrin uptake translocator protein (tspo) family.

    Polymorphism databases

    DMDMi 313104268.

    Proteomic databases

    MaxQBi P30536.
    PaxDbi P30536.
    PRIDEi P30536.

    Protocols and materials databases

    DNASUi 706.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000329563 ; ENSP00000328973 ; ENSG00000100300 . [P30536-1 ]
    ENST00000337554 ; ENSP00000338004 ; ENSG00000100300 . [P30536-1 ]
    GeneIDi 706.
    KEGGi hsa:706.
    UCSCi uc003bdn.4. human. [P30536-1 ]

    Organism-specific databases

    CTDi 706.
    GeneCardsi GC22P043547.
    HGNCi HGNC:1158. TSPO.
    HPAi CAB011232.
    HPA046260.
    MIMi 109610. gene.
    neXtProti NX_P30536.
    PharmGKBi PA25473.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG3476.
    HOGENOMi HOG000224659.
    InParanoidi P30536.
    KOi K05770.
    OMAi ALNYRIW.
    OrthoDBi EOG7V7687.
    PhylomeDBi P30536.
    TreeFami TF342852.

    Miscellaneous databases

    ChiTaRSi TSPO. human.
    GeneWikii Translocator_protein.
    GenomeRNAii 706.
    NextBioi 2874.
    PROi P30536.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P30536.
    Bgeei P30536.
    CleanExi HS_TSPO.
    Genevestigatori P30536.

    Family and domain databases

    InterProi IPR004307. TspO_MBR.
    [Graphical view ]
    PANTHERi PTHR10057. PTHR10057. 1 hit.
    Pfami PF03073. TspO_MBR. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF005859. PBR. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and chromosomal localization of a human peripheral-type benzodiazepine receptor."
      Riond J., Mattei M.-G., Kaghad M., Dumont X., Guillemot J.-C., le Fur G., Caput D., Ferrara P.
      Eur. J. Biochem. 195:305-311(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANTS ALA-147 AND HIS-162, FUNCTION, SUBCELLULAR LOCATION.
    2. "Comparison of repetitive elements in the third intron of human and rodent mitochondrial benzodiazepine receptor-encoding genes."
      Yakovlev A.G., Ruffo M., Jurka J., Krueger K.E.
      Gene 155:201-205(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "Peripheral benzodiazepine receptor: characterization in human T-lymphoma Jurkat cells."
      Costa B., Salvetti A., Rossi L., Spinetti F., Lena A., Chelli B., Rechichi M., Da Pozzo E., Gremigni V., Martini C.
      Mol. Pharmacol. 69:37-44(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    4. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
      Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS ALA-147 AND HIS-162.
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS ALA-147 AND HIS-162.
    6. NIEHS SNPs program
      Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS ALA-147 AND GLN-169.
    7. "The DNA sequence of human chromosome 22."
      Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M.
      , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H.
      Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Lymph.
    9. "Cloning and characterization of PRAX-1. A new protein that specifically interacts with the peripheral benzodiazepine receptor."
      Galiegue S., Jbilo O., Combes T., Bribes E., Carayon P., Le Fur G., Casellas P.
      J. Biol. Chem. 274:2938-2952(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH BZRAP1.
      Tissue: Brain.
    10. "Translocator protein (18kDa): new nomenclature for the peripheral-type benzodiazepine receptor based on its structure and molecular function."
      Papadopoulos V., Baraldi M., Guilarte T.R., Knudsen T.B., Lacapere J.-J., Lindemann P., Norenberg M.D., Nutt D., Weizman A., Zhang M.-R., Gavish M.
      Trends Pharmacol. Sci. 27:402-409(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NOMENCLATURE.
    11. "Cellular expression, localization and interactions of the product of the human MOST-1 gene associated with breast and prostate cancers."
      Tan J.M.M., Chow V.T.K.
      Int. J. Oncol. 30:81-89(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH MOST-1.
    12. "Regulation of translocator protein 18 kDa (TSPO) expression in health and disease states."
      Batarseh A., Papadopoulos V.
      Mol. Cell. Endocrinol. 327:1-12(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.
    13. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    14. "Targeting mitochondrial 18kDa translocator protein (TSPO) regulates macrophage cholesterol efflux and lipid phenotype."
      Taylor J.M., Allen A.M., Graham A.
      Clin. Sci. 0:0-0(2014) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    15. "An association study between two missense variations of the benzodiazepine receptor (peripheral) gene and schizophrenia in a Japanese sample."
      Kurumaji A., Nomoto H., Yoshikawa T., Okubo Y., Toru M.
      J. Neural Transm. 107:491-500(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS ALA-147 AND HIS-162.
    16. "No association of two missense variations of the benzodiazepine receptor (peripheral) gene and mood disorders in a Japanese sample."
      Kurumaji A., Nomoto H., Yamada K., Yoshikawa T., Toru M.
      Am. J. Med. Genet. 105:172-175(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS ALA-147 AND HIS-162.
    17. "The spontaneous Ala147Thr amino acid substitution within the translocator protein influences pregnenolone production in lymphomonocytes of healthy individuals."
      Costa B., Pini S., Gabelloni P., Da Pozzo E., Abelli M., Lari L., Preve M., Lucacchini A., Cassano G.B., Martini C.
      Endocrinology 150:5438-5445(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: CHARACTERIZATION OF VARIANT ALA-147.

    Entry informationi

    Entry nameiTSPOA_HUMAN
    AccessioniPrimary (citable) accession number: P30536
    Secondary accession number(s): Q53Y59, Q6ICF9, Q96TF6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 1, 1993
    Last sequence update: November 30, 2010
    Last modified: October 1, 2014
    This is version 132 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 22
      Human chromosome 22: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3