##gff-version 3
P30533	UniProtKB	Signal peptide	1	34	.	.	.	Ontology_term=ECO:0000255;evidence=ECO:0000255	
P30533	UniProtKB	Chain	35	357	.	.	.	ID=PRO_0000020724;Note=Alpha-2-macroglobulin receptor-associated protein	
P30533	UniProtKB	Region	32	52	.	.	.	Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite	
P30533	UniProtKB	Region	237	353	.	.	.	Note=LDL receptor binding;Ontology_term=ECO:0000255;evidence=ECO:0000255	
P30533	UniProtKB	Coiled coil	219	310	.	.	.	Ontology_term=ECO:0000255;evidence=ECO:0000255	
P30533	UniProtKB	Motif	354	357	.	.	.	Note=Prevents secretion from ER;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:7774585;Dbxref=PMID:7774585	
P30533	UniProtKB	Compositional bias	36	52	.	.	.	Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite	
P30533	UniProtKB	Modified residue	50	50	.	.	.	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99068	
P30533	UniProtKB	Modified residue	135	135	.	.	.	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P55302	
P30533	UniProtKB	Modified residue	248	248	.	.	.	Note=Phosphothreonine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:24275569;Dbxref=PMID:24275569	
P30533	UniProtKB	Glycosylation	268	268	.	.	.	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19159218;Dbxref=PMID:19159218	
P30533	UniProtKB	Natural variant	114	114	.	.	.	ID=VAR_050660;Note=N->S;Dbxref=dbSNP:rs2228158	
P30533	UniProtKB	Natural variant	311	311	.	.	.	ID=VAR_011821;Note=V->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9782079;Dbxref=dbSNP:rs1800493,PMID:9782079	
P30533	UniProtKB	Mutagenesis	283	283	.	.	.	Note=Strongly reduced interaction with LRP1%3B when associated with A-291%3B A-293%3B A-302%3B A-307 and A-341. H->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16678114;Dbxref=PMID:16678114	
P30533	UniProtKB	Mutagenesis	290	290	.	.	.	Note=Reduces competition with MAPT for binding to LRP1%3B when associated with A-304. K->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:32296178;Dbxref=PMID:32296178	
P30533	UniProtKB	Mutagenesis	291	291	.	.	.	Note=Strongly reduced interaction with LRP1%3B when associated with A-283%3B A-293%3B A-302%3B A-307 and A-341. H->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16678114;Dbxref=PMID:16678114	
P30533	UniProtKB	Mutagenesis	293	293	.	.	.	Note=Strongly reduced interaction with LRP1%3B when associated with A-283%3B A-291%3B A-302%3B A-307 and A-341. H->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16678114;Dbxref=PMID:16678114	
P30533	UniProtKB	Mutagenesis	302	302	.	.	.	Note=Strongly reduced interaction with LRP1%3B when associated with A-283%3B A-291%3B A-293%3B A-307 and A-341. H->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16678114;Dbxref=PMID:16678114	
P30533	UniProtKB	Mutagenesis	304	304	.	.	.	Note=Reduces competition with MAPT for binding to LRP1%3B when associated with A-290. K->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:32296178;Dbxref=PMID:32296178	
P30533	UniProtKB	Mutagenesis	307	307	.	.	.	Note=Strongly reduced interaction with LRP1%3B when associated with A-283%3B A-291%3B A-293%3B A-302 and A-341. H->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16678114;Dbxref=PMID:16678114	
P30533	UniProtKB	Mutagenesis	341	341	.	.	.	Note=Strongly reduced interaction with LRP1%3B when associated with A-283%3B A-291%3B A-293%3B A-302 and A-307. H->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16678114;Dbxref=PMID:16678114	
P30533	UniProtKB	Sequence conflict	100	100	.	.	.	Note=G->D;Ontology_term=ECO:0000305;evidence=ECO:0000305	
P30533	UniProtKB	Sequence conflict	183	183	.	.	.	Note=V->A;Ontology_term=ECO:0000305;evidence=ECO:0000305	
P30533	UniProtKB	Sequence conflict	339	339	.	.	.	Note=K->M;Ontology_term=ECO:0000305;evidence=ECO:0000305	
P30533	UniProtKB	Beta strand	53	56	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1LRE	
P30533	UniProtKB	Helix	57	68	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1LRE	
P30533	UniProtKB	Helix	73	99	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1LRE	
P30533	UniProtKB	Helix	107	122	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1LRE	
P30533	UniProtKB	Beta strand	124	126	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1NRE	
P30533	UniProtKB	Beta strand	127	130	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1OP1	
P30533	UniProtKB	Helix	149	161	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2P01	
P30533	UniProtKB	Helix	166	195	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2P01	
P30533	UniProtKB	Beta strand	208	210	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2P01	
P30533	UniProtKB	Beta strand	213	216	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2P01	
P30533	UniProtKB	Helix	217	243	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2P01	
P30533	UniProtKB	Beta strand	246	249	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2FTU	
P30533	UniProtKB	Helix	255	265	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2FCW	
P30533	UniProtKB	Helix	271	311	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2FCW	
P30533	UniProtKB	Turn	314	316	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2FCW	
P30533	UniProtKB	Helix	317	353	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2FCW