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Protein

Tyrosine-protein kinase receptor UFO

Gene

AXL

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding growth factor GAS6 and which is thus regulating many physiological processes including cell survival, cell proliferation, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of AXL. Following activation by ligand, ALX binds and induces tyrosine phosphorylation of PI3-kinase subunits PIK3R1, PIK3R2 and PIK3R3; but also GRB2, PLCG1, LCK and PTPN11. Other downstream substrate candidates for AXL are CBL, NCK2, SOCS1 and TNS2. Recruitment of GRB2 and phosphatidylinositol 3 kinase regulatory subunits by AXL leads to the downstream activation of the AKT kinase. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response.8 Publications
(Microbial infection) Acts as a receptor for lassa virus and lymphocytic choriomeningitis virus, possibly through GAS6 binding to phosphatidyl-serine at the surface of virion envelope (PubMed:22156524, PubMed:22673088, PubMed:25277499, PubMed:21501828). Acts as a receptor for ebolavirus, possibly through GAS6 binding to phosphatidyl-serine at the surface of virion envelope (PubMed:17005688).5 Publications

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.PROSITE-ProRule annotation

Enzyme regulationi

Activated by GAS6-binding and subsequent autophosphorylation.2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei567ATPPROSITE-ProRule annotation1
Active sitei672Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi542 – 550ATPPROSITE-ProRule annotation9

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • phosphatidylserine binding Source: UniProtKB
  • protein tyrosine kinase activity Source: Reactome
  • transmembrane receptor protein tyrosine kinase activity Source: ProtInc
  • virus receptor activity Source: UniProtKB-KW

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Host cell receptor for virus entry, Kinase, Receptor, Transferase, Tyrosine-protein kinase

Keywords - Biological processi

Differentiation, Host-virus interaction, Immunity, Innate immunity

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciZFISH:HS09589-MONOMER.
BRENDAi2.7.10.1. 2681.
ReactomeiR-HSA-4420097. VEGFA-VEGFR2 Pathway.
SignaLinkiP30530.
SIGNORiP30530.

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein kinase receptor UFO (EC:2.7.10.1)
Alternative name(s):
AXL oncogene
Gene namesi
Name:AXL
Synonyms:UFO
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:905. AXL.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini26 – 451ExtracellularSequence analysisAdd BLAST426
Transmembranei452 – 472HelicalSequence analysisAdd BLAST21
Topological domaini473 – 894CytoplasmicSequence analysisAdd BLAST422

GO - Cellular componenti

  • cell surface Source: UniProtKB
  • extracellular exosome Source: UniProtKB
  • extracellular space Source: UniProtKB
  • host cell surface Source: CACAO
  • integral component of plasma membrane Source: ProtInc
  • intracellular Source: GOC
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Involvement in diseasei

AXL and its ligand GAS6 are highly expressed in thyroid carcinoma tissues, and might thus be involved in thyroid tumorigenesis. Overexpression of AXL and its ligand was also detected in many other cancers such as myeloproliferative disorders, prostatic carcinoma cells, or breast cancer.

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi63E → R: Slightly reduced affinity for GAS6. 1 Publication1
Mutagenesisi66E → R: Reduced affinity for GAS6. 1 Publication1
Mutagenesisi84T → R: Reduced affinity for GAS6. 1 Publication1

Keywords - Diseasei

Oncogene, Proto-oncogene

Organism-specific databases

DisGeNETi558.
PharmGKBiPA25197.

Chemistry databases

ChEMBLiCHEMBL4895.
GuidetoPHARMACOLOGYi1835.

Polymorphism and mutation databases

BioMutaiAXL.
DMDMi239938818.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_000002448126 – 894Tyrosine-protein kinase receptor UFOAdd BLAST869

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi43N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi56 ↔ 117PROSITE-ProRule annotation
Glycosylationi157N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi160 ↔ 205PROSITE-ProRule annotation
Glycosylationi198N-linked (GlcNAc...)Sequence analysis1
Glycosylationi339N-linked (GlcNAc...)Sequence analysis1
Glycosylationi345N-linked (GlcNAc...)Sequence analysis1
Glycosylationi401N-linked (GlcNAc...)Sequence analysis1
Modified residuei703Phosphotyrosine; by autocatalysisBy similarity1
Modified residuei779Phosphotyrosine; by autocatalysis2 Publications1
Modified residuei821Phosphotyrosine; by autocatalysis2 Publications1
Modified residuei866Phosphotyrosine; by autocatalysis2 Publications1
Modified residuei884PhosphoserineCombined sources1

Post-translational modificationi

Monoubiquitinated upon GAS6-binding. A very small proportion of the receptor could be subjected to polyubiquitination in a very transient fashion.1 Publication
Phosphorylated at tyrosine residues by autocatalysis, which activates kinase activity.2 Publications

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP30530.
MaxQBiP30530.
PaxDbiP30530.
PeptideAtlasiP30530.
PRIDEiP30530.

PTM databases

iPTMnetiP30530.
PhosphoSitePlusiP30530.

Expressioni

Tissue specificityi

Highly expressed in metastatic colon tumors. Expressed in primary colon tumors. Weakly expressed in normal colon tissue.1 Publication

Gene expression databases

BgeeiENSG00000167601.
CleanExiHS_AXL.
ExpressionAtlasiP30530. baseline and differential.
GenevisibleiP30530. HS.

Organism-specific databases

HPAiCAB032501.
HPA037422.
HPA037423.

Interactioni

Subunit structurei

Heterodimer and heterotetramer with ligand GAS6. Interacts with CBL, GRB2, LCK, NCK2, PIK3R1, PIK3R2, PIK3R3, PLCG1, SOCS1 and TNS2. Part of a complex including AXL, TNK2 and GRB2, in which GRB2 promotes AXL recruitment by TNK2.8 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
EGFRP005334EBI-2850927,EBI-297353
GAS6Q143938EBI-2850927,EBI-2802811
GRB2P629933EBI-2850927,EBI-401755

Protein-protein interaction databases

BioGridi107036. 17 interactors.
IntActiP30530. 16 interactors.
MINTiMINT-2735752.
STRINGi9606.ENSP00000301178.

Chemistry databases

BindingDBiP30530.

Structurei

Secondary structure

1894
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi37 – 39Combined sources3
Beta strandi44 – 46Combined sources3
Beta strandi52 – 63Combined sources12
Beta strandi67 – 71Combined sources5
Beta strandi80 – 106Combined sources27
Helixi109 – 111Combined sources3
Beta strandi113 – 121Combined sources9
Beta strandi124 – 127Combined sources4
Beta strandi131 – 135Combined sources5
Beta strandi140 – 143Combined sources4
Beta strandi148 – 150Combined sources3
Beta strandi156 – 159Combined sources4
Beta strandi161 – 163Combined sources3
Beta strandi165 – 167Combined sources3
Beta strandi170 – 175Combined sources6
Beta strandi178 – 187Combined sources10
Beta strandi190 – 194Combined sources5
Beta strandi201 – 209Combined sources9
Beta strandi212 – 215Combined sources4
Beta strandi219 – 223Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2C5DX-ray3.30C/D33-227[»]
4RA0X-ray3.07C/D33-227[»]
ProteinModelPortaliP30530.
SMRiP30530.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP30530.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini27 – 128Ig-like C2-type 1Add BLAST102
Domaini139 – 222Ig-like C2-type 2Add BLAST84
Domaini227 – 331Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST105
Domaini336 – 428Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST93
Domaini536 – 807Protein kinasePROSITE-ProRule annotationAdd BLAST272

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni26 – 92Interaction with GAS6Add BLAST67

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family. AXL/UFO subfamily.PROSITE-ProRule annotation
Contains 2 fibronectin type-III domains.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IG6I. Eukaryota.
COG0515. LUCA.
HOGENOMiHOG000231685.
HOVERGENiHBG006346.
InParanoidiP30530.
KOiK05115.
OrthoDBiEOG091G016X.
PhylomeDBiP30530.
TreeFamiTF317402.

Family and domain databases

CDDicd00063. FN3. 2 hits.
Gene3Di2.60.40.10. 4 hits.
InterProiIPR003961. FN3_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view]
PfamiPF00041. fn3. 2 hits.
PF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
PRINTSiPR00109. TYRKINASE.
SMARTiSM00060. FN3. 2 hits.
SM00409. IG. 2 hits.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 2 hits.
SSF49265. SSF49265. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS50853. FN3. 2 hits.
PS50835. IG_LIKE. 2 hits.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform Long (identifier: P30530-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAWRCPRMGR VPLAWCLALC GWACMAPRGT QAEESPFVGN PGNITGARGL
60 70 80 90 100
TGTLRCQLQV QGEPPEVHWL RDGQILELAD STQTQVPLGE DEQDDWIVVS
110 120 130 140 150
QLRITSLQLS DTGQYQCLVF LGHQTFVSQP GYVGLEGLPY FLEEPEDRTV
160 170 180 190 200
AANTPFNLSC QAQGPPEPVD LLWLQDAVPL ATAPGHGPQR SLHVPGLNKT
210 220 230 240 250
SSFSCEAHNA KGVTTSRTAT ITVLPQQPRN LHLVSRQPTE LEVAWTPGLS
260 270 280 290 300
GIYPLTHCTL QAVLSNDGMG IQAGEPDPPE EPLTSQASVP PHQLRLGSLH
310 320 330 340 350
PHTPYHIRVA CTSSQGPSSW THWLPVETPE GVPLGPPENI SATRNGSQAF
360 370 380 390 400
VHWQEPRAPL QGTLLGYRLA YQGQDTPEVL MDIGLRQEVT LELQGDGSVS
410 420 430 440 450
NLTVCVAAYT AAGDGPWSLP VPLEAWRPGQ AQPVHQLVKE PSTPAFSWPW
460 470 480 490 500
WYVLLGAVVA AACVLILALF LVHRRKKETR YGEVFEPTVE RGELVVRYRV
510 520 530 540 550
RKSYSRRTTE ATLNSLGISE ELKEKLRDVM VDRHKVALGK TLGEGEFGAV
560 570 580 590 600
MEGQLNQDDS ILKVAVKTMK IAICTRSELE DFLSEAVCMK EFDHPNVMRL
610 620 630 640 650
IGVCFQGSER ESFPAPVVIL PFMKHGDLHS FLLYSRLGDQ PVYLPTQMLV
660 670 680 690 700
KFMADIASGM EYLSTKRFIH RDLAARNCML NENMSVCVAD FGLSKKIYNG
710 720 730 740 750
DYYRQGRIAK MPVKWIAIES LADRVYTSKS DVWSFGVTMW EIATRGQTPY
760 770 780 790 800
PGVENSEIYD YLRQGNRLKQ PADCLDGLYA LMSRCWELNP QDRPSFTELR
810 820 830 840 850
EDLENTLKAL PPAQEPDEIL YVNMDEGGGY PEPPGAAGGA DPPTQPDPKD
860 870 880 890
SCSCLTAAEV HPAGRYVLCP STTPSPAQPA DRGSPAAPGQ EDGA
Length:894
Mass (Da):98,336
Last modified:June 16, 2009 - v3
Checksum:i2C2D3574EADA4116
GO
Isoform Short (identifier: P30530-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     429-437: Missing.

Show »
Length:885
Mass (Da):97,377
Checksum:iAFF0212BA8EAEAA1
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti303T → P in AAB20305 (PubMed:1834974).Curated1
Sequence conflicti303T → P in CAA40338 (PubMed:1834974).Curated1
Sequence conflicti338E → K in AAA61243 (PubMed:1656220).Curated1
Sequence conflicti430Q → E in AAB20305 (PubMed:1834974).Curated1
Sequence conflicti430Q → E in CAA40338 (PubMed:1834974).Curated1
Sequence conflicti639D → G in AAB20305 (PubMed:1834974).Curated1
Sequence conflicti639D → G in CAA40338 (PubMed:1834974).Curated1
Sequence conflicti696K → I no nucleotide entry (PubMed:7896447).Curated1
Sequence conflicti764Q → R in AAH32229 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_045596112T → M.1 PublicationCorresponds to variant rs35202236dbSNPEnsembl.1
Natural variantiVAR_057990266N → D.4 PublicationsCorresponds to variant rs7249222dbSNPEnsembl.1
Natural variantiVAR_045597295R → W in a lung neuroendocrine carcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_041877499R → C in a gastric adenocarcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_041878515S → G.1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_005017429 – 437Missing in isoform Short. 1 Publication9

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M76125 mRNA. Translation: AAA61243.1.
S65125 mRNA. Translation: AAB20305.1.
X57019 mRNA. Translation: CAA40338.1.
AC011510 Genomic DNA. No translation available.
BC032229 mRNA. Translation: AAH32229.1.
CCDSiCCDS12574.1. [P30530-2]
CCDS12575.1. [P30530-1]
PIRiA41527.
RefSeqiNP_001690.2. NM_001699.5.
NP_068713.2. NM_021913.4.
UniGeneiHs.590970.

Genome annotation databases

EnsembliENST00000301178; ENSP00000301178; ENSG00000167601.
ENST00000359092; ENSP00000351995; ENSG00000167601.
GeneIDi558.
KEGGihsa:558.
UCSCiuc010ehj.5. human. [P30530-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M76125 mRNA. Translation: AAA61243.1.
S65125 mRNA. Translation: AAB20305.1.
X57019 mRNA. Translation: CAA40338.1.
AC011510 Genomic DNA. No translation available.
BC032229 mRNA. Translation: AAH32229.1.
CCDSiCCDS12574.1. [P30530-2]
CCDS12575.1. [P30530-1]
PIRiA41527.
RefSeqiNP_001690.2. NM_001699.5.
NP_068713.2. NM_021913.4.
UniGeneiHs.590970.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2C5DX-ray3.30C/D33-227[»]
4RA0X-ray3.07C/D33-227[»]
ProteinModelPortaliP30530.
SMRiP30530.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107036. 17 interactors.
IntActiP30530. 16 interactors.
MINTiMINT-2735752.
STRINGi9606.ENSP00000301178.

Chemistry databases

BindingDBiP30530.
ChEMBLiCHEMBL4895.
GuidetoPHARMACOLOGYi1835.

PTM databases

iPTMnetiP30530.
PhosphoSitePlusiP30530.

Polymorphism and mutation databases

BioMutaiAXL.
DMDMi239938818.

Proteomic databases

EPDiP30530.
MaxQBiP30530.
PaxDbiP30530.
PeptideAtlasiP30530.
PRIDEiP30530.

Protocols and materials databases

DNASUi558.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000301178; ENSP00000301178; ENSG00000167601.
ENST00000359092; ENSP00000351995; ENSG00000167601.
GeneIDi558.
KEGGihsa:558.
UCSCiuc010ehj.5. human. [P30530-1]

Organism-specific databases

CTDi558.
DisGeNETi558.
GeneCardsiAXL.
HGNCiHGNC:905. AXL.
HPAiCAB032501.
HPA037422.
HPA037423.
MIMi109135. gene.
neXtProtiNX_P30530.
PharmGKBiPA25197.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IG6I. Eukaryota.
COG0515. LUCA.
HOGENOMiHOG000231685.
HOVERGENiHBG006346.
InParanoidiP30530.
KOiK05115.
OrthoDBiEOG091G016X.
PhylomeDBiP30530.
TreeFamiTF317402.

Enzyme and pathway databases

BioCyciZFISH:HS09589-MONOMER.
BRENDAi2.7.10.1. 2681.
ReactomeiR-HSA-4420097. VEGFA-VEGFR2 Pathway.
SignaLinkiP30530.
SIGNORiP30530.

Miscellaneous databases

ChiTaRSiAXL. human.
EvolutionaryTraceiP30530.
GeneWikiiAXL_receptor_tyrosine_kinase.
GenomeRNAii558.
PROiP30530.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000167601.
CleanExiHS_AXL.
ExpressionAtlasiP30530. baseline and differential.
GenevisibleiP30530. HS.

Family and domain databases

CDDicd00063. FN3. 2 hits.
Gene3Di2.60.40.10. 4 hits.
InterProiIPR003961. FN3_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view]
PfamiPF00041. fn3. 2 hits.
PF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
PRINTSiPR00109. TYRKINASE.
SMARTiSM00060. FN3. 2 hits.
SM00409. IG. 2 hits.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 2 hits.
SSF49265. SSF49265. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS50853. FN3. 2 hits.
PS50835. IG_LIKE. 2 hits.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiUFO_HUMAN
AccessioniPrimary (citable) accession number: P30530
Secondary accession number(s): Q8N5L2, Q9UD27
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: June 16, 2009
Last modified: November 30, 2016
This is version 186 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.