Reviewed, UniProtKB/Swiss-Prot P30528 (CYAA_YERIN)

Names and origin

Protein names

Recommended name:
    Adenylate cyclase
    EC=4.6.1.1
Alternative name(s):
    ATP pyrophosphate-lyase
    Adenylyl cyclase

Gene names

Name:

cya

Organism

Yersinia intermedia

Taxonomic identifier

631 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Yersinia

Protein attributes

Sequence length	848 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	ATP = 3',5'-cyclic AMP + diphosphate.
Enzyme regulation	The regulatory domain is involved in the regulation of cyclase activity by the carbon source.
Subcellular location	Cytoplasm.
Sequence similarities	Belongs to the adenylyl cyclase class-1 family.

Ontologies

Keywords
Biological process	cAMP biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Lyase
Gene Ontology (GO)
Biological process	cAMP biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW adenylate cyclase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 848	848	Adenylate cyclase		PRO_0000195679
Regions
	Region	1 – 535	535	Catalytic Potential
	Region	541 – 848	308	Regulatory Potential

Sequences

	Sequence		Length	Mass (Da)
	P30528-1 [UniParc]. Last modified April 1, 1993. Version 1. Checksum: 1D9AB11F0D282FAD	FASTA	848	96,879
	10 20 30 40 50 60 MYLYIETLKQ RLDAINQLRV DRALAAMGPT FQKVYSLLPT LLHCHHPLMP GYLDGNVPHG 70 80 90 100 110 120 VCLFTPNETQ QDYLSEVEAK WGEPLQQSVG GELPITGVYS MGSTSSIGQC HTSDLDVWVC 130 140 150 160 170 180 HQAWLDSEER NRLQEKCSLL EKWAASMGVE VSFFLIDENR FRHNASGSLG GEDCGSTQHI 190 200 210 220 230 240 LLLDEFYRSA VRLAGKRILW NMVPVEEENN YDDYVLSLYA QGVLTPNEWL DLGGLSTLSA 250 260 270 280 290 300 EEYFGASLWQ LYKSIDSPYK AVLKTLLLEA YSWEYPNSQL LAMEIKQRLH AGEIVAFGLD 310 320 330 340 350 360 AYCMMLDRVT RYLTQINDTT RLNLVRRCFY LKVCEKLSRS PASVGWRREI LSQLVSEWGW 370 380 390 400 410 420 SDESLAVLDN RANWKIERVR EAHNELLDAM MQSYRNLIRF ARRNNLSVSA SPQDIGVLTR 430 440 450 460 470 480 KLYAAFEALP GKVTLVNPQI SPDLSEEHLT FIHVPAGRAN RAGWYLYNQA PSMDAIVSHQ 490 500 510 520 530 540 PLEYNRYLNK LVSWAYFNGL LTSKTRLHIK SANLCDTVKL QELVTDISHH FPLRLPAPTP 550 560 570 580 590 600 KALYSPCEIR HLAIIVNLEH DPTAAFRNQV VHFDFRKLDV FSFGEQQQCL VGSIDLLYRN 610 620 630 640 650 660 SWNEVRTLHF SGEQAVLEAL KTILGKMHQD AAPPESVDVF CYSQHLRGLI RTRIQQLVSE 670 680 690 700 710 720 CIELRLSSTR QEPGRFKAVR VSGHTWGLFF ERLSVSVQKL ENAVEFYGAI SNNKLHGLSI 730 740 750 760 770 780 QVETDQIHLP PVVDGFASEG IIQFFFEGTA DEKGFNIYIL DESNRVEVYH HCEGSKEALV 790 800 810 820 830 840 RDVSRFYSSS HDRFTYGSSF INFNLPQFYQ IVQLDGRTQV IPFRSNTLSH LYIVDREPSQ PAQQFQLH

References

[1]	Glaser P., Sismeiro O., Danchin A. Submitted (JUN-1992) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Phylogeny of adenylyl cyclases." Danchin A. Adv. Second Messenger Phosphoprotein Res. 27:109-162(1993) [PubMed: 8418825] [Abstract] Cited for: REVIEW.

Cross-references

Sequence databases
EMBLGenBankDDBJ	X66781 Genomic DNA. Translation: CAA47277.1. Sequence problems.
PIR	S24981.
3D structure databases
ModBase	Search...
Enzyme and pathway databases
BRENDA	4.6.1.1. 291645.
Family and domain databases
InterPro	IPR000274. Adenylt_cyclse_1. [Graphical view]
Pfam	PF01295. Adenylate_cycl. 1 hit. [Graphical view]
PIRSF	PIRSF001444. Adenylate_cycl. 1 hit.
PROSITE	PS01092. ADENYLATE_CYCLASE_1_1. 1 hit. PS01093. ADENYLATE_CYCLASE_1_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CYAA_YERIN

Accession

Primary (citable) accession number: P30528

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 1, 1993
Last sequence update:	April 1, 1993
Last modified:	June 16, 2009
This is version 44 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)