P30526 (TRPE_BACCA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Anthranilate synthase component 1
EC=4.1.3.27

Alternative name(s):
Anthranilate synthase component I

Gene names

Name:

trpE

Organism

Bacillus caldotenax

Taxonomic identifier

1395 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus

Protein attributes

Sequence length	508 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate.
Pathway	Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 1/5.
Subunit structure	Tetramer of two components I and two components II By similarity.
Miscellaneous	Component I catalyzes the formation of anthranilate using ammonia rather than glutamine, whereas component II provides glutamine amidotransferase activity.
Sequence similarities	Belongs to the anthranilate synthase component I family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis Tryptophan biosynthesis
Molecular function	Lyase
Gene Ontology (GO)
Biological process	tryptophan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	anthranilate synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 508	508	Anthranilate synthase component 1		PRO_0000154076

Sequences

	Sequence		Length	Mass (Da)
	P30526 [UniParc]. Last modified April 1, 1993. Version 1. Checksum: 3DA113D811A77797	FASTA	508	56,493
	10 20 30 40 50 60 MSADGLAAFL AEANEFRTIP IVRKFVADVI EPLGVFANLR EEAVFLLESK DDESPWARYS 70 80 90 100 110 120 FIGVAPFLTL ESETGETFSV KDENGNEQIT APTLKEAFQW VERTLAVKPL AETVPFTGGA 130 140 150 160 170 180 VGFLGYDFIS AIEKVPRHKN RDVPMKTAYF VFCESLFAFD QKKRELLVIH YIRLSGNETE 190 200 210 220 230 240 EEKIEAYRAA ERRMADLAAK AARPQAEQPL LPAESESGRT ASFAKAVSNY DKKQFLRDVE 250 260 270 280 290 300 AVKRYIAAGD VFQAVLSQRF CVPVQAGGFA IYRLLRYINP SPYMFYFQLD GVEIVGSSPE 310 320 330 340 350 360 KLIQVHRRRV EIDPIAGTRR RGRSPEEDER LADELYHDPK ERAEHYMLVD LARNDIGRVA 370 380 390 400 410 420 KYGTVEVPVL LQIGKFSHVM HLISKVVGEL DDNVHPIDAL LAAFPAGTVS GAPKVRAMQI 430 440 450 460 470 480 LQELEPTARG LYAGAIAYIG FDGNIDSCIA IRTAVVKDGY AYVQAGAGIV ADSVPELEWK 490 500 ETRNKASALM NAIEQAERLF AKGERAVC

References

[1]	"Nucleotide sequence of trpE, anthranilate synthase I gene, of Bacillus caldotenax." Shiratsuchi A., Sato S. Biochim. Biophys. Acta 1090:348-350(1991) [PubMed: 1840498] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X55703 Genomic DNA. Translation: CAA39230.1.
PIR	S19266.
3D structure databases
ProteinModelPortal	P30526.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR005801. ADC_synthase. IPR019999. Anth_synth_I. IPR006805. Anth_synth_I_N. IPR005256. Anth_synth_I_PabB. IPR015890. Chorismate-bd_C. [Graphical view]
Gene3D	G3DSA:3.60.120.10. TRPE_1_chor_bd. 1 hit.
Pfam	PF04715. Anth_synt_I_N. 1 hit. PF00425. Chorismate_bind. 1 hit. [Graphical view]
PRINTS	PR00095. ANTSNTHASEI.
SUPFAM	SSF56322. TRPE_1_chor_bd. 1 hit.
TIGRFAMs	TIGR00564. TrpE_most. 1 hit.
ProtoNet	Search...

Entry information

Entry name

TRPE_BACCA

Accession

Primary (citable) accession number: P30526

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 1, 1993
Last sequence update:	April 1, 1993
Last modified:	September 21, 2011
This is version 64 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program