Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P30518

- V2R_HUMAN

UniProt

P30518 - V2R_HUMAN

Protein

Vasopressin V2 receptor

Gene

AVPR2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 159 (01 Oct 2014)
      Sequence version 1 (01 Apr 1993)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Involved in renal water reabsorption.1 Publication

    GO - Molecular functioni

    1. protein binding Source: UniProt
    2. vasopressin receptor activity Source: UniProtKB

    GO - Biological processi

    1. activation of adenylate cyclase activity Source: ProtInc
    2. adenylate cyclase-modulating G-protein coupled receptor signaling pathway Source: ProtInc
    3. excretion Source: ProtInc
    4. hemostasis Source: ProtInc
    5. I-kappaB kinase/NF-kappaB signaling Source: Ensembl
    6. interferon-gamma production Source: Ensembl
    7. negative regulation of renal sodium excretion Source: Ensembl
    8. negative regulation of urine volume Source: Ensembl
    9. positive regulation of cell proliferation Source: Ensembl
    10. positive regulation of gene expression Source: UniProtKB
    11. positive regulation of protein ubiquitination Source: BHF-UCL
    12. positive regulation of systemic arterial blood pressure Source: Ensembl
    13. response to cytokine Source: Ensembl
    14. telencephalon development Source: Ensembl
    15. transmembrane transport Source: Reactome
    16. water transport Source: Reactome

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Enzyme and pathway databases

    ReactomeiREACT_17041. Vasopressin-like receptors.
    REACT_19327. G alpha (s) signalling events.
    REACT_24023. Regulation of water balance by renal Aquaporins.
    SignaLinkiP30518.

    Protein family/group databases

    TCDBi9.A.14.10.3. the g-protein-coupled receptor (gpcr) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Vasopressin V2 receptor
    Short name:
    V2R
    Alternative name(s):
    AVPR V2
    Antidiuretic hormone receptor
    Renal-type arginine vasopressin receptor
    Gene namesi
    Name:AVPR2
    Synonyms:ADHR, DIR, DIR3, V2R
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome X

    Organism-specific databases

    HGNCiHGNC:897. AVPR2.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum Source: ProtInc
    2. endosome Source: ProtInc
    3. Golgi apparatus Source: ProtInc
    4. integral component of membrane Source: UniProtKB
    5. integral component of plasma membrane Source: ProtInc
    6. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Involvement in diseasei

    Nephrogenic syndrome of inappropriate antidiuresis (NSIAD) [MIM:300539]: Characterized by an inability to excrete a free water load, with inappropriately concentrated urine and resultant hyponatremia, hypoosmolarity, and natriuresis.1 Publication
    Note: The disease is caused by mutations affecting the gene represented in this entry.
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti137 – 1371R → C in NSIAD; constitutively active. 1 Publication
    VAR_025901
    Natural varianti137 – 1371R → L in NSIAD; constitutively active. 1 Publication
    VAR_025902
    Diabetes insipidus, nephrogenic, X-linked (XNDI) [MIM:304800]: A disorder caused by the inability of the renal collecting ducts to absorb water in response to arginine vasopressin. Characterized by excessive water drinking (polydipsia), excessive urine excretion (polyuria), persistent hypotonic urine, and hypokalemia.22 Publications
    Note: The disease is caused by mutations affecting the gene represented in this entry.
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti43 – 431L → P in XNDI. 1 Publication
    VAR_015297
    Natural varianti44 – 441L → P in XNDI. 1 Publication
    VAR_003517
    Natural varianti46 – 461I → K in XNDI. 1 Publication
    VAR_015298
    Natural varianti53 – 531L → R in XNDI.
    VAR_015299
    Natural varianti55 – 551N → D in XNDI.
    VAR_015300
    Natural varianti55 – 551N → H in XNDI.
    VAR_015301
    Natural varianti59 – 591L → P in XNDI.
    VAR_015302
    Natural varianti62 – 643Missing in XNDI.
    VAR_003518
    Natural varianti62 – 621L → P in XNDI.
    VAR_015304
    Natural varianti80 – 801H → R in XNDI. 1 Publication
    VAR_003520
    Natural varianti81 – 811L → F in XNDI.
    VAR_015305
    Natural varianti83 – 831L → P in XNDI.
    VAR_015306
    Natural varianti83 – 831L → Q in XNDI.
    VAR_015307
    Natural varianti84 – 841A → D in XNDI.
    VAR_015308
    Natural varianti85 – 851D → N in XNDI.
    VAR_015309
    Natural varianti88 – 881V → M in XNDI.
    VAR_003521
    Natural varianti92 – 921Q → R in XNDI.
    VAR_015310
    Natural varianti94 – 941L → Q in XNDI.
    VAR_015311
    Natural varianti95 – 951P → L in XNDI.
    VAR_015312
    Natural varianti99 – 991W → R in XNDI.
    VAR_015313
    Natural varianti104 – 1041R → C in XNDI; binding capacity is 10% of wild-type, but binding affinity is stronger than wild-type. 1 Publication
    VAR_015314
    Natural varianti105 – 1051F → V in XNDI. 1 Publication
    VAR_015315
    Natural varianti106 – 1061R → C in XNDI. 1 Publication
    VAR_003522
    Natural varianti107 – 1071G → E in XNDI. 1 Publication
    VAR_015316
    Natural varianti112 – 1121C → R in XNDI. 1 Publication
    VAR_003523
    Natural varianti112 – 1121C → Y in XNDI.
    VAR_015317
    Natural varianti113 – 1131R → W in XNDI. 2 Publications
    Corresponds to variant rs28935496 [ dbSNP | Ensembl ].
    VAR_003524
    Natural varianti122 – 1221G → D in XNDI. 1 Publication
    VAR_062591
    Natural varianti122 – 1221G → R in XNDI.
    VAR_015318
    Natural varianti123 – 1231M → K in XNDI.
    VAR_015319
    Natural varianti126 – 1261S → F in XNDI.
    VAR_003525
    Natural varianti127 – 1271S → F in XNDI.
    VAR_015320
    Natural varianti128 – 1281Y → S in XNDI. 2 Publications
    VAR_003526
    Natural varianti130 – 1301I → F in XNDI. 1 Publication
    VAR_015321
    Natural varianti132 – 1321A → D in XNDI. 1 Publication
    VAR_003527
    Natural varianti135 – 1351L → P in XNDI.
    VAR_015322
    Natural varianti137 – 1371R → H in XNDI; fails to activate the adenylyl cyclase system. 4 Publications
    VAR_003528
    Natural varianti143 – 1431R → P in XNDI. 2 Publications
    VAR_003529
    Natural varianti163 – 1631A → P in XNDI.
    VAR_015324
    Natural varianti164 – 1641W → S in XNDI.
    VAR_003531
    Natural varianti167 – 1671S → L in XNDI.
    VAR_003532
    Natural varianti167 – 1671S → T in XNDI. 1 Publication
    VAR_003533
    Natural varianti173 – 1731P → S in XNDI.
    VAR_015325
    Natural varianti174 – 1741Q → L in XNDI.
    VAR_015326
    Natural varianti181 – 1811R → C in XNDI. 2 Publications
    VAR_003534
    Natural varianti185 – 1851G → C in XNDI. 1 Publication
    VAR_003535
    Natural varianti191 – 1911D → G in XNDI.
    VAR_015327
    Natural varianti201 – 2011G → D in XNDI.
    VAR_015328
    Natural varianti202 – 2021R → C in XNDI. 1 Publication
    VAR_003536
    Natural varianti203 – 2031R → C in XNDI. 1 Publication
    VAR_003537
    Natural varianti204 – 2041T → N in XNDI.
    VAR_015329
    Natural varianti205 – 2051Y → C in XNDI. 1 Publication
    VAR_003538
    Natural varianti206 – 2061V → D in XNDI.
    VAR_015330
    Natural varianti207 – 2071T → N in XNDI.
    VAR_015331
    Natural varianti209 – 2091I → F in XNDI.
    VAR_015332
    Natural varianti214 – 2141F → S in XNDI.
    VAR_015333
    Natural varianti217 – 2171P → T in XNDI.
    VAR_015335
    Natural varianti219 – 2191L → P in XNDI.
    VAR_015336
    Natural varianti219 – 2191L → R in XNDI.
    VAR_015337
    Natural varianti247 – 2504Missing in XNDI.
    VAR_003539
    Natural varianti272 – 2721M → K in XNDI.
    VAR_015339
    Natural varianti277 – 2771V → A in XNDI.
    VAR_015340
    Natural varianti280 – 2801Y → C in XNDI. 2 Publications
    VAR_003541
    Natural varianti282 – 2821L → P in XNDI.
    VAR_015341
    Natural varianti286 – 2861P → L in XNDI. 1 Publication
    VAR_003543
    Natural varianti286 – 2861P → R in XNDI. 1 Publication
    VAR_003544
    Natural varianti286 – 2861P → S in XNDI.
    VAR_015342
    Natural varianti287 – 2871F → L in XNDI. 1 Publication
    VAR_015343
    Natural varianti289 – 2891L → P in XNDI.
    VAR_015344
    Natural varianti292 – 2921L → P in XNDI. 1 Publication
    VAR_003545
    Natural varianti294 – 2941A → P in XNDI.
    VAR_015345
    Natural varianti309 – 3091L → P in XNDI. 1 Publication
    VAR_003546
    Natural varianti309 – 3091L → R in XNDI.
    VAR_015346
    Natural varianti315 – 3151S → R in XNDI.
    VAR_015347
    Natural varianti317 – 3171N → K in XNDI. 1 Publication
    VAR_003547
    Natural varianti319 – 3191C → R in XNDI.
    VAR_015349
    Natural varianti321 – 3211N → D in XNDI.
    VAR_015350
    Natural varianti321 – 3211N → K in XNDI.
    VAR_015351
    Natural varianti321 – 3211N → Y in XNDI.
    VAR_015352
    Natural varianti322 – 3221P → H in XNDI.
    VAR_015353
    Natural varianti322 – 3221P → S in XNDI. 1 Publication
    VAR_015354
    Natural varianti323 – 3231W → R in XNDI.
    VAR_015355
    Natural varianti323 – 3231W → S in XNDI. 1 Publication
    VAR_003548

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi341 – 3411C → S: Reduced palmitoylation, reduced cell surface localization but coupling to G protein unaffected. 1 Publication
    Mutagenesisi342 – 3421C → S: Reduced palmitoylation, reduced cell surface localization but coupling to G protein unaffected. 1 Publication

    Keywords - Diseasei

    Diabetes insipidus, Disease mutation

    Organism-specific databases

    MIMi300539. phenotype.
    304800. phenotype.
    Orphaneti83449. Inappropriate antidiuretic hormone secretion syndrome.
    223. Nephrogenic diabetes insipidus.
    93606. Nephrogenic syndrome of inappropriate antidiuresis.
    PharmGKBiPA25189.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 371371Vasopressin V2 receptorPRO_0000070208Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi22 – 221N-linked (GlcNAc...)Sequence Analysis
    Lipidationi341 – 3411S-palmitoyl cysteine1 Publication
    Lipidationi342 – 3421S-palmitoyl cysteine1 Publication

    Keywords - PTMi

    Glycoprotein, Lipoprotein, Palmitate

    Proteomic databases

    PaxDbiP30518.
    PRIDEiP30518.

    PTM databases

    PhosphoSiteiP30518.

    Expressioni

    Tissue specificityi

    Kidney.

    Gene expression databases

    ArrayExpressiP30518.
    BgeeiP30518.
    CleanExiHS_AVPR2.
    GenevestigatoriP30518.

    Organism-specific databases

    HPAiHPA046678.

    Interactioni

    Protein-protein interaction databases

    BioGridi107035. 14 interactions.
    STRINGi9606.ENSP00000338072.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4JQIX-ray2.60V343-371[»]
    ProteinModelPortaliP30518.
    SMRiP30518. Positions 41-364.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 3838ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini64 – 7714CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini99 – 11315ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini136 – 15924CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini181 – 20020ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini221 – 27151CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini294 – 30815ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini329 – 37143CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei39 – 6325Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei78 – 9821Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei114 – 13522Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei160 – 18021Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei201 – 22020Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei272 – 29322Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei309 – 32820Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG299951.
    HOGENOMiHOG000237331.
    HOVERGENiHBG105710.
    InParanoidiP30518.
    KOiK04228.
    OMAiGGARWNR.
    PhylomeDBiP30518.
    TreeFamiTF106499.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR001817. Vasoprsn_rcpt.
    IPR000161. Vprsn_rcpt_V2.
    [Graphical view]
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR00896. VASOPRESSINR.
    PR00898. VASOPRSNV2R.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P30518-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MLMASTTSAV PGHPSLPSLP SNSSQERPLD TRDPLLARAE LALLSIVFVA    50
    VALSNGLVLA ALARRGRRGH WAPIHVFIGH LCLADLAVAL FQVLPQLAWK 100
    ATDRFRGPDA LCRAVKYLQM VGMYASSYMI LAMTLDRHRA ICRPMLAYRH 150
    GSGAHWNRPV LVAWAFSLLL SLPQLFIFAQ RNVEGGSGVT DCWACFAEPW 200
    GRRTYVTWIA LMVFVAPTLG IAACQVLIFR EIHASLVPGP SERPGGRRRG 250
    RRTGSPGEGA HVSAAVAKTV RMTLVIVVVY VLCWAPFFLV QLWAAWDPEA 300
    PLEGAPFVLL MLLASLNSCT NPWIYASFSS SVSSELRSLL CCARGRTPPS 350
    LGPQDESCTT ASSSLAKDTS S 371
    Length:371
    Mass (Da):40,279
    Last modified:April 1, 1993 - v1
    Checksum:i1F87D20A3C0ECB0D
    GO
    Isoform 2 (identifier: P30518-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         305-309: APFVL → GCSRG
         310-371: Missing.

    Show »
    Length:309
    Mass (Da):33,743
    Checksum:iCAB6A8B0A682ED0F
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti7 – 71T → S.
    Corresponds to variant rs5196 [ dbSNP | Ensembl ].
    VAR_003516
    Natural varianti12 – 121G → E.
    Corresponds to variant rs2071126 [ dbSNP | Ensembl ].
    VAR_015296
    Natural varianti42 – 421A → V.
    Corresponds to variant rs5198 [ dbSNP | Ensembl ].
    VAR_011858
    Natural varianti43 – 431L → P in XNDI. 1 Publication
    VAR_015297
    Natural varianti44 – 441L → P in XNDI. 1 Publication
    VAR_003517
    Natural varianti46 – 461I → K in XNDI. 1 Publication
    VAR_015298
    Natural varianti53 – 531L → R in XNDI.
    VAR_015299
    Natural varianti55 – 551N → D in XNDI.
    VAR_015300
    Natural varianti55 – 551N → H in XNDI.
    VAR_015301
    Natural varianti59 – 591L → P in XNDI.
    VAR_015302
    Natural varianti61 – 611A → V.
    VAR_015303
    Natural varianti62 – 643Missing in XNDI.
    VAR_003518
    Natural varianti62 – 621L → P in XNDI.
    VAR_015304
    Natural varianti64 – 641R → W.
    Corresponds to variant rs150351033 [ dbSNP | Ensembl ].
    VAR_003519
    Natural varianti80 – 801H → R in XNDI. 1 Publication
    VAR_003520
    Natural varianti81 – 811L → F in XNDI.
    VAR_015305
    Natural varianti83 – 831L → P in XNDI.
    VAR_015306
    Natural varianti83 – 831L → Q in XNDI.
    VAR_015307
    Natural varianti84 – 841A → D in XNDI.
    VAR_015308
    Natural varianti85 – 851D → N in XNDI.
    VAR_015309
    Natural varianti88 – 881V → M in XNDI.
    VAR_003521
    Natural varianti92 – 921Q → R in XNDI.
    VAR_015310
    Natural varianti94 – 941L → Q in XNDI.
    VAR_015311
    Natural varianti95 – 951P → L in XNDI.
    VAR_015312
    Natural varianti99 – 991W → R in XNDI.
    VAR_015313
    Natural varianti104 – 1041R → C in XNDI; binding capacity is 10% of wild-type, but binding affinity is stronger than wild-type. 1 Publication
    VAR_015314
    Natural varianti105 – 1051F → V in XNDI. 1 Publication
    VAR_015315
    Natural varianti106 – 1061R → C in XNDI. 1 Publication
    VAR_003522
    Natural varianti107 – 1071G → E in XNDI. 1 Publication
    VAR_015316
    Natural varianti112 – 1121C → R in XNDI. 1 Publication
    VAR_003523
    Natural varianti112 – 1121C → Y in XNDI.
    VAR_015317
    Natural varianti113 – 1131R → W in XNDI. 2 Publications
    Corresponds to variant rs28935496 [ dbSNP | Ensembl ].
    VAR_003524
    Natural varianti122 – 1221G → D in XNDI. 1 Publication
    VAR_062591
    Natural varianti122 – 1221G → R in XNDI.
    VAR_015318
    Natural varianti123 – 1231M → K in XNDI.
    VAR_015319
    Natural varianti126 – 1261S → F in XNDI.
    VAR_003525
    Natural varianti127 – 1271S → F in XNDI.
    VAR_015320
    Natural varianti128 – 1281Y → S in XNDI. 2 Publications
    VAR_003526
    Natural varianti130 – 1301I → F in XNDI. 1 Publication
    VAR_015321
    Natural varianti132 – 1321A → D in XNDI. 1 Publication
    VAR_003527
    Natural varianti135 – 1351L → P in XNDI.
    VAR_015322
    Natural varianti137 – 1371R → C in NSIAD; constitutively active. 1 Publication
    VAR_025901
    Natural varianti137 – 1371R → H in XNDI; fails to activate the adenylyl cyclase system. 4 Publications
    VAR_003528
    Natural varianti137 – 1371R → L in NSIAD; constitutively active. 1 Publication
    VAR_025902
    Natural varianti139 – 1391R → S.
    VAR_015323
    Natural varianti143 – 1431R → P in XNDI. 2 Publications
    VAR_003529
    Natural varianti147 – 1471A → V.
    Corresponds to variant rs5200 [ dbSNP | Ensembl ].
    VAR_003530
    Natural varianti163 – 1631A → P in XNDI.
    VAR_015324
    Natural varianti164 – 1641W → S in XNDI.
    VAR_003531
    Natural varianti167 – 1671S → L in XNDI.
    VAR_003532
    Natural varianti167 – 1671S → T in XNDI. 1 Publication
    VAR_003533
    Natural varianti173 – 1731P → S in XNDI.
    VAR_015325
    Natural varianti174 – 1741Q → L in XNDI.
    VAR_015326
    Natural varianti181 – 1811R → C in XNDI. 2 Publications
    VAR_003534
    Natural varianti185 – 1851G → C in XNDI. 1 Publication
    VAR_003535
    Natural varianti191 – 1911D → G in XNDI.
    VAR_015327
    Natural varianti201 – 2011G → D in XNDI.
    VAR_015328
    Natural varianti202 – 2021R → C in XNDI. 1 Publication
    VAR_003536
    Natural varianti203 – 2031R → C in XNDI. 1 Publication
    VAR_003537
    Natural varianti204 – 2041T → N in XNDI.
    VAR_015329
    Natural varianti205 – 2051Y → C in XNDI. 1 Publication
    VAR_003538
    Natural varianti206 – 2061V → D in XNDI.
    VAR_015330
    Natural varianti207 – 2071T → N in XNDI.
    VAR_015331
    Natural varianti209 – 2091I → F in XNDI.
    VAR_015332
    Natural varianti214 – 2141F → S in XNDI.
    VAR_015333
    Natural varianti215 – 2151V → M.
    VAR_015334
    Natural varianti217 – 2171P → T in XNDI.
    VAR_015335
    Natural varianti219 – 2191L → P in XNDI.
    VAR_015336
    Natural varianti219 – 2191L → R in XNDI.
    VAR_015337
    Natural varianti247 – 2504Missing in XNDI.
    VAR_003539
    Natural varianti247 – 2471R → H in a breast cancer sample; somatic mutation. 1 Publication
    VAR_035769
    Natural varianti252 – 2521R → W.
    Corresponds to variant rs61733407 [ dbSNP | Ensembl ].
    VAR_015338
    Natural varianti272 – 2721M → K in XNDI.
    VAR_015339
    Natural varianti277 – 2771V → A in XNDI.
    VAR_015340
    Natural varianti277 – 2771Missing in CDNI. 4 Publications
    VAR_003540
    Natural varianti280 – 2801Y → C in XNDI. 2 Publications
    VAR_003541
    Natural varianti282 – 2821L → P in XNDI.
    VAR_015341
    Natural varianti285 – 2851A → P in CDNI.
    VAR_003542
    Natural varianti286 – 2861P → L in XNDI. 1 Publication
    VAR_003543
    Natural varianti286 – 2861P → R in XNDI. 1 Publication
    VAR_003544
    Natural varianti286 – 2861P → S in XNDI.
    VAR_015342
    Natural varianti287 – 2871F → L in XNDI. 1 Publication
    VAR_015343
    Natural varianti289 – 2891L → P in XNDI.
    VAR_015344
    Natural varianti292 – 2921L → P in XNDI. 1 Publication
    VAR_003545
    Natural varianti294 – 2941A → P in XNDI.
    VAR_015345
    Natural varianti309 – 3091L → P in XNDI. 1 Publication
    VAR_003546
    Natural varianti309 – 3091L → R in XNDI.
    VAR_015346
    Natural varianti315 – 3151S → R in XNDI.
    VAR_015347
    Natural varianti317 – 3171N → K in XNDI. 1 Publication
    VAR_003547
    Natural varianti318 – 3181S → T.
    VAR_015348
    Natural varianti319 – 3191C → R in XNDI.
    VAR_015349
    Natural varianti321 – 3211N → D in XNDI.
    VAR_015350
    Natural varianti321 – 3211N → K in XNDI.
    VAR_015351
    Natural varianti321 – 3211N → Y in XNDI.
    VAR_015352
    Natural varianti322 – 3221P → H in XNDI.
    VAR_015353
    Natural varianti322 – 3221P → S in XNDI. 1 Publication
    VAR_015354
    Natural varianti323 – 3231W → R in XNDI.
    VAR_015355
    Natural varianti323 – 3231W → S in XNDI. 1 Publication
    VAR_003548
    Natural varianti352 – 3521G → D.
    VAR_015356

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei305 – 3095APFVL → GCSRG in isoform 2. 1 PublicationVSP_036990
    Alternative sequencei310 – 37162Missing in isoform 2. 1 PublicationVSP_036991Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L22206 Genomic DNA. Translation: AAA03651.1.
    Z11687 mRNA. Translation: CAA77746.1.
    U04357 Genomic DNA. Translation: AAC09005.1.
    AF030626 mRNA. Translation: AAB86428.1.
    AF101727 mRNA. Translation: AAD16444.1.
    AF032388 mRNA. Translation: AAB87678.1.
    AY242131 mRNA. Translation: AAO92298.1.
    FJ411207 Genomic DNA. Translation: ACR39021.1.
    CH471172 Genomic DNA. Translation: EAW72783.1.
    CH471172 Genomic DNA. Translation: EAW72784.1.
    CH471172 Genomic DNA. Translation: EAW72785.1.
    BC101484 mRNA. Translation: AAI01485.1.
    BC112181 mRNA. Translation: AAI12182.1.
    CCDSiCCDS14735.1. [P30518-1]
    CCDS55539.1. [P30518-2]
    PIRiI51865.
    RefSeqiNP_000045.1. NM_000054.4. [P30518-1]
    NP_001139623.1. NM_001146151.1. [P30518-2]
    XP_006724891.1. XM_006724828.1. [P30518-1]
    UniGeneiHs.567240.

    Genome annotation databases

    EnsembliENST00000337474; ENSP00000338072; ENSG00000126895. [P30518-1]
    ENST00000358927; ENSP00000351805; ENSG00000126895. [P30518-1]
    ENST00000370049; ENSP00000359066; ENSG00000126895. [P30518-2]
    GeneIDi554.
    KEGGihsa:554.
    UCSCiuc004fjh.4. human. [P30518-1]
    uc004fji.3. human. [P30518-2]

    Polymorphism databases

    DMDMi267256.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Web resourcesi

    Nephrogenic and neurogenic Diabetes Insipidus

    AVPR2 pages

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L22206 Genomic DNA. Translation: AAA03651.1 .
    Z11687 mRNA. Translation: CAA77746.1 .
    U04357 Genomic DNA. Translation: AAC09005.1 .
    AF030626 mRNA. Translation: AAB86428.1 .
    AF101727 mRNA. Translation: AAD16444.1 .
    AF032388 mRNA. Translation: AAB87678.1 .
    AY242131 mRNA. Translation: AAO92298.1 .
    FJ411207 Genomic DNA. Translation: ACR39021.1 .
    CH471172 Genomic DNA. Translation: EAW72783.1 .
    CH471172 Genomic DNA. Translation: EAW72784.1 .
    CH471172 Genomic DNA. Translation: EAW72785.1 .
    BC101484 mRNA. Translation: AAI01485.1 .
    BC112181 mRNA. Translation: AAI12182.1 .
    CCDSi CCDS14735.1. [P30518-1 ]
    CCDS55539.1. [P30518-2 ]
    PIRi I51865.
    RefSeqi NP_000045.1. NM_000054.4. [P30518-1 ]
    NP_001139623.1. NM_001146151.1. [P30518-2 ]
    XP_006724891.1. XM_006724828.1. [P30518-1 ]
    UniGenei Hs.567240.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4JQI X-ray 2.60 V 343-371 [» ]
    ProteinModelPortali P30518.
    SMRi P30518. Positions 41-364.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 107035. 14 interactions.
    STRINGi 9606.ENSP00000338072.

    Chemistry

    BindingDBi P30518.
    ChEMBLi CHEMBL1790.
    DrugBanki DB00872. Conivaptan.
    DB02638. Terlipressin.
    DB00067. Vasopressin.
    GuidetoPHARMACOLOGYi 368.

    Protein family/group databases

    TCDBi 9.A.14.10.3. the g-protein-coupled receptor (gpcr) family.
    GPCRDBi Search...

    PTM databases

    PhosphoSitei P30518.

    Polymorphism databases

    DMDMi 267256.

    Proteomic databases

    PaxDbi P30518.
    PRIDEi P30518.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000337474 ; ENSP00000338072 ; ENSG00000126895 . [P30518-1 ]
    ENST00000358927 ; ENSP00000351805 ; ENSG00000126895 . [P30518-1 ]
    ENST00000370049 ; ENSP00000359066 ; ENSG00000126895 . [P30518-2 ]
    GeneIDi 554.
    KEGGi hsa:554.
    UCSCi uc004fjh.4. human. [P30518-1 ]
    uc004fji.3. human. [P30518-2 ]

    Organism-specific databases

    CTDi 554.
    GeneCardsi GC0XP153167.
    GeneReviewsi AVPR2.
    HGNCi HGNC:897. AVPR2.
    HPAi HPA046678.
    MIMi 300538. gene.
    300539. phenotype.
    304800. phenotype.
    neXtProti NX_P30518.
    Orphaneti 83449. Inappropriate antidiuretic hormone secretion syndrome.
    223. Nephrogenic diabetes insipidus.
    93606. Nephrogenic syndrome of inappropriate antidiuresis.
    PharmGKBi PA25189.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG299951.
    HOGENOMi HOG000237331.
    HOVERGENi HBG105710.
    InParanoidi P30518.
    KOi K04228.
    OMAi GGARWNR.
    PhylomeDBi P30518.
    TreeFami TF106499.

    Enzyme and pathway databases

    Reactomei REACT_17041. Vasopressin-like receptors.
    REACT_19327. G alpha (s) signalling events.
    REACT_24023. Regulation of water balance by renal Aquaporins.
    SignaLinki P30518.

    Miscellaneous databases

    GeneWikii Arginine_vasopressin_receptor_2.
    GenomeRNAii 554.
    NextBioi 2289.
    PROi P30518.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P30518.
    Bgeei P30518.
    CleanExi HS_AVPR2.
    Genevestigatori P30518.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR001817. Vasoprsn_rcpt.
    IPR000161. Vprsn_rcpt_V2.
    [Graphical view ]
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR00896. VASOPRESSINR.
    PR00898. VASOPRSNV2R.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Structure and chromosomal localization of the human antidiuretic hormone receptor gene."
      Seibold A., Brabet P., Rosenthal W., Birnbaumer M.
      Am. J. Hum. Genet. 51:1078-1083(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Molecular cloning of the receptor for human antidiuretic hormone."
      Birnbaumer M., Seibold A., Gilbert S., Ishido M., Barberis C., Antaramian A., Brabet P., Rosenthal W.
      Nature 357:333-335(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Kidney.
    3. "Heterogeneous AVPR2 gene mutations in congenital nephrogenic diabetes insipidus."
      Wildin R.S., Antush M.J., Bennett R.L., Schoof J.M., Scott C.R.
      Am. J. Hum. Genet. 55:266-277(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    4. "Evidence for expression of vasopressin V2 receptor mRNA in human lung."
      Fay M.J., Du J., Yu X., North W.G.
      Peptides 17:477-481(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Lung.
    5. "Expression of all known vasopressin receptor subtypes by small cell tumors implies a multifaceted role for this neuropeptide."
      North W.G., Fay M.J., Longo K.A., Du J.
      Cancer Res. 58:1866-1871(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
      Tissue: Lung carcinoma and Mammary cancer.
    6. "Involvement of the V2 vasopressin receptor in adaptation to limited water supply."
      Boselt I., Rompler H., Hermsdorf T., Thor D., Busch W., Schulz A., Schoneberg T.
      PLoS ONE 4:E5573-E5573(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION.
    7. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
      Warren C.N., Aronstam R.S., Sharma S.V.
      Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Kidney.
    8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain.
    10. "Two novel mutations in the aquaporin-2 and the vasopressin V2 receptor genes in patients with congenital nephrogenic diabetes insipidus."
      Oksche A., Moeller A., Dickson J., Rosendahl W., Rascher W., Bichet D.G., Rosenthal W.
      Hum. Genet. 98:587-589(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 307-371.
    11. "Palmitoylation of the V2 vasopressin receptor."
      Sadeghi H.M., Innamorati G., Dagarag M., Birnbaumer M.
      Mol. Pharmacol. 52:21-29(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: PALMITOYLATION AT CYS-341 AND CYS-342, MUTAGENESIS OF CYS-341 AND CYS-342.
    12. "Molecular identification of the gene responsible for congenital nephrogenic diabetes insipidus."
      Rosenthal W., Seibold A., Antaramian A., Lonergan M., Arthus M.-F., Hendy G.N., Birnbaumer M., Bichet D.G.
      Nature 359:233-235(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT XNDI ASP-132.
    13. "Mutations in the vasopressin type 2 receptor gene (AVPR2) associated with nephrogenic diabetes insipidus."
      van den Ouweland A.M.W., Dreesen J.C.F.M., Verdijk M., Knoers N.V.A.M., Monnens L.A.H., Rocchi M., van Oost B.A.
      Nat. Genet. 2:99-102(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS XNDI CYS-185; CYS-203 AND CYS-205.
    14. "Mutations in the V2 vasopressin receptor gene are associated with X-linked nephrogenic diabetes insipidus."
      Pan Y., Metzenberg A., Das S., Jing B., Gitschier J.
      Nat. Genet. 2:103-106(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS XNDI SER-128; CYS-181; ARG-286 AND 247-ARG--GLY-250 DEL.
    15. "Two novel mutations in the vasopressin V2 receptor gene in unrelated Japanese kindreds with nephrogenic diabetes insipidus."
      Tsukaguchi H., Matsubara H., Aritaki S., Kimura T., Abe S., Inada M.
      Biochem. Biophys. Res. Commun. 197:1000-1010(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS XNDI PRO-143 AND VAL-277 DEL.
    16. "A molecular defect in the vasopressin V2-receptor gene causing nephrogenic diabetes insipidus."
      Holtzman E.J., Harris H.W. Jr., Kolakowski L.F. Jr., Guay-Woodford L.M., Botelho B., Ausiello D.A.
      N. Engl. J. Med. 328:1534-1537(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT XNDI TRP-113.
    17. "Nephrogenic diabetes insipidus. A V2 vasopressin receptor unable to stimulate adenylyl cyclase."
      Rosenthal W., Antaramian A., Gilbert S., Birnbaumer M.
      J. Biol. Chem. 268:13030-13033(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT XNDI HIS-137.
    18. "Nature and recurrence of AVPR2 mutations in X-linked nephrogenic diabetes insipidus."
      Bichet D.G., Birnbaumer M., Lonergan M., Arthus M.-F., Rosenthal W., Goodyer P., Nivet H., Benoit S., Giampietro P., Simonetti S., Fish A., Whitley C.B., Jaeger P., Gertner J., New M., Dibona F.J., Kaplan B.S., Robertson G.L.
      , Hendy G.N., Fujiwara T.M., Morgan K.
      Am. J. Hum. Genet. 55:278-286(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS XNDI.
    19. "Two novel mutations in the vasopressin V2 receptor gene in patients with congenital nephrogenic diabetes insipidus."
      Oksche A., Dickson J., Schuelein R., Hansjoerg W.S., Mueller M., Rascher W., Birnbaumer M., Rosenthal W.
      Biochem. Biophys. Res. Commun. 205:552-557(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS XNDI PRO-44 AND THR-167.
    20. "Novel mutations in the V2 vasopressin receptor gene of patients with X-linked nephrogenic diabetes insipidus."
      Wenkert D., Merendino J.J. Jr., Shenker A., Thambi N., Robertson G.L., Moses A.M., Spiegel A.M.
      Hum. Mol. Genet. 3:1429-1430(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS XNDI CYS-280 AND PRO-292.
    21. "Mutations in the vasopressin V2-receptor gene in three families of Italian descent with nephrogenic diabetes insipidus."
      Faa V., Ventruto M.L., Loche S., Bozzola M., Podda R., Cao A., Rosatelli M.C.
      Hum. Mol. Genet. 3:1685-1686(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS XNDI SER-128; VAL-277 DEL AND LEU-286.
    22. "Novel mutations in the V2 vasopressin receptor gene in two pedigrees with congenital nephrogenic diabetes insipidus."
      Yuasa H., Ito M., Oiso Y., Kurokawa M., Watanabe T., Oda Y., Ishizuka T., Tani N., Ito S., Shibata A., Saito H.
      J. Clin. Endocrinol. Metab. 79:361-365(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT XNDI ARG-80.
    23. "An extracellular congenital nephrogenic diabetes insipidus mutation of the vasopressin receptor reduces cell surface expression, affinity for ligand, and coupling to the Gs/adenylyl cyclase system."
      Birnbaumer M., Gilbert S., Rosenthal W.
      Mol. Endocrinol. 8:886-894(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT XNDI TRP-113.
    24. "Nephrogenic diabetes insipidus: an X chromosome-linked dominant inheritance pattern with a vasopressin type 2 receptor gene that is structurally normal."
      Friedman E., Bale A.E., Carson E., Boson W.L., Nordenskjoeld M., Ritzen M., Ferriera P.C., Jammal A., De Marco L.
      Proc. Natl. Acad. Sci. U.S.A. 91:8457-8461(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT XNDI CYS-280.
    25. "Binding-, intracellular transport-, and biosynthesis-defective mutants of vasopressin type 2 receptor in patients with X-linked nephrogenic diabetes insipidus."
      Tsukaguchi H., Matsubara H., Taketani S., Mori Y., Seido T., Inada M.
      J. Clin. Invest. 96:2043-2050(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS XNDI PRO-143; CYS-202 AND VAL-277 DEL.
    26. "Mutations in the vasopressin V2 receptor and aquaporin-2 genes in 12 families with congenital nephrogenic diabetes insipidus."
      Vargas-Poussou R., Forestier L., Dautzenberg M.D., Niaudet P., Dechaux M., Antignac C.
      J. Am. Soc. Nephrol. 8:1855-1862(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS XNDI PRO-43; GLU-107 AND SER-322.
    27. "Mutational analyses of AVPR2 gene in three Japanese families with X-linked nephrogenic diabetes insipidus: two recurrent mutations, R137H and deltaV278, caused by the hypermutability at CpG dinucleotides."
      Shoji Y., Takahashi T., Suzuki Y., Suzuki T., Komatsu K., Hirono H., Shoji Y., Yokoyama T., Kito H., Takada G.
      Hum. Mutat. Suppl. 1:S278-S283(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS XNDI HIS-137; VAL-277 DEL AND PRO-309.
    28. "C112R, W323S, N317K mutations in the vasopressin V2 receptor gene in patients with nephrogenic diabetes insipidus."
      Szalai C., Triga D., Czinner A.
      Hum. Mutat. 12:137-138(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS XNDI ARG-112; LYS-317 AND SER-323.
    29. "V2 vasopressin receptor dysfunction in nephrogenic diabetes insipidus caused by different molecular mechanisms."
      Schoeneberg T., Schulz A., Biebermann H., Grueters A., Grimm T., Huebschmann K., Filler G., Gudermann T., Schultz G.
      Hum. Mutat. 12:196-205(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS XNDI HIS-137 AND CYS-181.
    30. "Functional characterization of the molecular defects causing nephrogenic diabetes insipidus in eight families."
      Pasel K., Schulz A., Timmermann K., Linnemann K., Hoeltzenbein M., Jaaskelainen J., Gruters A., Filler G., Schoneberg T.
      J. Clin. Endocrinol. Metab. 85:1703-1710(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS XNDI LYS-46; VAL-105 AND PHE-130.
    31. "Misfolded vasopressin V2 receptors caused by extracellular point mutations entail congenital nephrogenic diabetes insipidus."
      Postina R., Ufer E., Pfeiffer R., Knoers N.V., Fahrenholz F.
      Mol. Cell. Endocrinol. 164:31-39(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: CHARACTERIZATION OF VARIANTS XNDI ASN-204; CYS-205 AND ASP-206.
    32. "The property of a novel V2 receptor mutant in a patient with nephrogenic diabetes insipidus."
      Inaba S., Hatakeyama H., Taniguchi N., Miyamori I.
      J. Clin. Endocrinol. Metab. 86:381-385(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT XNDI CYS-104.
    33. "Identification of mutations in the arginine vasopressin receptor 2 gene causing nephrogenic diabetes insipidus in Chinese patients."
      Chen C.H., Chen W.Y., Liu H.L., Liu T.T., Tsou A.P., Lin C.Y., Chao T., Qi Y., Hsiao K.J.
      J. Hum. Genet. 47:66-73(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS XNDI CYS-106 AND LEU-287.
    34. Cited for: VARIANTS NSIAD CYS-137 AND LEU-137.
    35. "Novel mutations underlying nephrogenic diabetes insipidus in Arab families."
      Carroll P., Al-Mojalli H., Al-Abbad A., Al-Hassoun I., Al-Hamed M., Al-Amr R., Butt A.I., Meyer B.F.
      Genet. Med. 8:443-447(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS XNDI ASP-122 AND HIS-137.
    36. Cited for: VARIANT [LARGE SCALE ANALYSIS] HIS-247.

    Entry informationi

    Entry nameiV2R_HUMAN
    AccessioniPrimary (citable) accession number: P30518
    Secondary accession number(s): C5HF20
    , O43192, Q3MJD3, Q9UCV9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 1, 1993
    Last sequence update: April 1, 1993
    Last modified: October 1, 2014
    This is version 159 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome X
      Human chromosome X: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    7. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3