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Protein

Vasopressin V2 receptor

Gene

AVPR2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Involved in renal water reabsorption.1 Publication

GO - Molecular functioni

  • peptide binding Source: GO_Central
  • vasopressin receptor activity Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-HSA-388479. Vasopressin-like receptors.
R-HSA-418555. G alpha (s) signalling events.
R-HSA-432040. Vasopressin regulates renal water homeostasis via Aquaporins.
R-HSA-5619099. Defective AVP causes neurohypophyseal diabetes insipidus (NDI).
SignaLinkiP30518.
SIGNORiP30518.

Protein family/group databases

TCDBi9.A.14.10.3. the g-protein-coupled receptor (gpcr) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Vasopressin V2 receptor
Short name:
V2R
Alternative name(s):
AVPR V2
Antidiuretic hormone receptor
Renal-type arginine vasopressin receptor
Gene namesi
Name:AVPR2
Synonyms:ADHR, DIR, DIR3, V2R
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:897. AVPR2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3838ExtracellularSequence analysisAdd
BLAST
Transmembranei39 – 6325Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini64 – 7714CytoplasmicSequence analysisAdd
BLAST
Transmembranei78 – 9821Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini99 – 11315ExtracellularSequence analysisAdd
BLAST
Transmembranei114 – 13522Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini136 – 15924CytoplasmicSequence analysisAdd
BLAST
Transmembranei160 – 18021Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini181 – 20020ExtracellularSequence analysisAdd
BLAST
Transmembranei201 – 22020Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini221 – 27151CytoplasmicSequence analysisAdd
BLAST
Transmembranei272 – 29322Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini294 – 30815ExtracellularSequence analysisAdd
BLAST
Transmembranei309 – 32820Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini329 – 37143CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • endoplasmic reticulum Source: ProtInc
  • endosome Source: ProtInc
  • Golgi apparatus Source: ProtInc
  • integral component of membrane Source: UniProtKB
  • integral component of plasma membrane Source: ProtInc
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Involvement in diseasei

Nephrogenic syndrome of inappropriate antidiuresis (NSIAD)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionCharacterized by an inability to excrete a free water load, with inappropriately concentrated urine and resultant hyponatremia, hypoosmolarity, and natriuresis.
See also OMIM:300539
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti137 – 1371R → C in NSIAD; constitutively active. 1 Publication
Corresponds to variant rs104894761 [ dbSNP | Ensembl ].
VAR_025901
Natural varianti137 – 1371R → L in NSIAD; constitutively active. 1 Publication
Corresponds to variant rs104894756 [ dbSNP | Ensembl ].
VAR_025902
Diabetes insipidus, nephrogenic, X-linked (XNDI)22 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disorder caused by the inability of the renal collecting ducts to absorb water in response to arginine vasopressin. Characterized by excessive water drinking (polydipsia), excessive urine excretion (polyuria), persistent hypotonic urine, and hypokalemia.
See also OMIM:304800
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti43 – 431L → P in XNDI. 1 Publication
VAR_015297
Natural varianti44 – 441L → P in XNDI. 1 Publication
VAR_003517
Natural varianti46 – 461I → K in XNDI. 1 Publication
Corresponds to variant rs104894759 [ dbSNP | Ensembl ].
VAR_015298
Natural varianti53 – 531L → R in XNDI.
VAR_015299
Natural varianti55 – 551N → D in XNDI.
VAR_015300
Natural varianti55 – 551N → H in XNDI.
VAR_015301
Natural varianti59 – 591L → P in XNDI.
Corresponds to variant rs193922112 [ dbSNP | Ensembl ].
VAR_015302
Natural varianti62 – 643Missing in XNDI.
VAR_003518
Natural varianti62 – 621L → P in XNDI.
VAR_015304
Natural varianti80 – 801H → R in XNDI. 1 Publication
VAR_003520
Natural varianti81 – 811L → F in XNDI.
VAR_015305
Natural varianti83 – 831L → P in XNDI.
VAR_015306
Natural varianti83 – 831L → Q in XNDI.
VAR_015307
Natural varianti84 – 841A → D in XNDI.
VAR_015308
Natural varianti85 – 851D → N in XNDI.
Corresponds to variant rs104894754 [ dbSNP | Ensembl ].
VAR_015309
Natural varianti88 – 881V → M in XNDI.
VAR_003521
Natural varianti92 – 921Q → R in XNDI.
VAR_015310
Natural varianti94 – 941L → Q in XNDI.
VAR_015311
Natural varianti95 – 951P → L in XNDI.
VAR_015312
Natural varianti99 – 991W → R in XNDI.
VAR_015313
Natural varianti104 – 1041R → C in XNDI; binding capacity is 10% of wild-type, but binding affinity is stronger than wild-type. 1 Publication
Corresponds to variant rs104894760 [ dbSNP | Ensembl ].
VAR_015314
Natural varianti105 – 1051F → V in XNDI. 1 Publication
Corresponds to variant rs104894758 [ dbSNP | Ensembl ].
VAR_015315
Natural varianti106 – 1061R → C in XNDI. 1 Publication
VAR_003522
Natural varianti107 – 1071G → E in XNDI. 1 Publication
VAR_015316
Natural varianti112 – 1121C → R in XNDI. 1 Publication
VAR_003523
Natural varianti112 – 1121C → Y in XNDI.
VAR_015317
Natural varianti113 – 1131R → W in XNDI. 2 Publications
Corresponds to variant rs28935496 [ dbSNP | Ensembl ].
VAR_003524
Natural varianti122 – 1221G → D in XNDI. 1 Publication
VAR_062591
Natural varianti122 – 1221G → R in XNDI.
VAR_015318
Natural varianti123 – 1231M → K in XNDI.
VAR_015319
Natural varianti126 – 1261S → F in XNDI.
VAR_003525
Natural varianti127 – 1271S → F in XNDI.
VAR_015320
Natural varianti128 – 1281Y → S in XNDI. 2 Publications
VAR_003526
Natural varianti130 – 1301I → F in XNDI. 1 Publication
Corresponds to variant rs796052096 [ dbSNP | Ensembl ].
VAR_015321
Natural varianti132 – 1321A → D in XNDI. 1 Publication
Corresponds to variant rs104894747 [ dbSNP | Ensembl ].
VAR_003527
Natural varianti135 – 1351L → P in XNDI.
VAR_015322
Natural varianti137 – 1371R → H in XNDI; fails to activate the adenylyl cyclase system. 4 Publications
Corresponds to variant rs104894756 [ dbSNP | Ensembl ].
VAR_003528
Natural varianti143 – 1431R → P in XNDI. 2 Publications
VAR_003529
Natural varianti163 – 1631A → P in XNDI.
VAR_015324
Natural varianti164 – 1641W → S in XNDI.
VAR_003531
Natural varianti167 – 1671S → L in XNDI.
VAR_003532
Natural varianti167 – 1671S → T in XNDI. 1 Publication
VAR_003533
Natural varianti173 – 1731P → S in XNDI.
VAR_015325
Natural varianti174 – 1741Q → L in XNDI.
VAR_015326
Natural varianti181 – 1811R → C in XNDI. 2 Publications
Corresponds to variant rs104894757 [ dbSNP | Ensembl ].
VAR_003534
Natural varianti185 – 1851G → C in XNDI. 1 Publication
Corresponds to variant rs104894748 [ dbSNP | Ensembl ].
VAR_003535
Natural varianti191 – 1911D → G in XNDI.
VAR_015327
Natural varianti201 – 2011G → D in XNDI.
Corresponds to variant rs104894755 [ dbSNP | Ensembl ].
VAR_015328
Natural varianti202 – 2021R → C in XNDI. 1 Publication
Corresponds to variant rs782806507 [ dbSNP | Ensembl ].
VAR_003536
Natural varianti203 – 2031R → C in XNDI. 1 Publication
Corresponds to variant rs104894750 [ dbSNP | Ensembl ].
VAR_003537
Natural varianti204 – 2041T → N in XNDI. 1 Publication
VAR_015329
Natural varianti205 – 2051Y → C in XNDI. 2 Publications
Corresponds to variant rs104894749 [ dbSNP | Ensembl ].
VAR_003538
Natural varianti206 – 2061V → D in XNDI. 1 Publication
VAR_015330
Natural varianti207 – 2071T → N in XNDI.
VAR_015331
Natural varianti209 – 2091I → F in XNDI.
VAR_015332
Natural varianti214 – 2141F → S in XNDI.
VAR_015333
Natural varianti217 – 2171P → T in XNDI.
VAR_015335
Natural varianti219 – 2191L → P in XNDI.
VAR_015336
Natural varianti219 – 2191L → R in XNDI.
VAR_015337
Natural varianti247 – 2504Missing in XNDI. 1 Publication
VAR_003539
Natural varianti272 – 2721M → K in XNDI.
VAR_015339
Natural varianti277 – 2771V → A in XNDI.
VAR_015340
Natural varianti280 – 2801Y → C in XNDI. 2 Publications
Corresponds to variant rs104894752 [ dbSNP | Ensembl ].
VAR_003541
Natural varianti282 – 2821L → P in XNDI.
VAR_015341
Natural varianti286 – 2861P → L in XNDI. 1 Publication
VAR_003543
Natural varianti286 – 2861P → R in XNDI. 1 Publication
VAR_003544
Natural varianti286 – 2861P → S in XNDI.
VAR_015342
Natural varianti287 – 2871F → L in XNDI. 1 Publication
VAR_015343
Natural varianti289 – 2891L → P in XNDI.
VAR_015344
Natural varianti292 – 2921L → P in XNDI. 1 Publication
VAR_003545
Natural varianti294 – 2941A → P in XNDI.
VAR_015345
Natural varianti309 – 3091L → P in XNDI. 1 Publication
VAR_003546
Natural varianti309 – 3091L → R in XNDI.
VAR_015346
Natural varianti315 – 3151S → R in XNDI.
VAR_015347
Natural varianti317 – 3171N → K in XNDI. 1 Publication
VAR_003547
Natural varianti319 – 3191C → R in XNDI.
VAR_015349
Natural varianti321 – 3211N → D in XNDI.
VAR_015350
Natural varianti321 – 3211N → K in XNDI.
Corresponds to variant rs193922123 [ dbSNP | Ensembl ].
VAR_015351
Natural varianti321 – 3211N → Y in XNDI.
VAR_015352
Natural varianti322 – 3221P → H in XNDI.
VAR_015353
Natural varianti322 – 3221P → S in XNDI. 1 Publication
VAR_015354
Natural varianti323 – 3231W → R in XNDI.
VAR_015355
Natural varianti323 – 3231W → S in XNDI. 1 Publication
VAR_003548

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi341 – 3411C → S: Reduced palmitoylation, reduced cell surface localization but coupling to G protein unaffected. 1 Publication
Mutagenesisi342 – 3421C → S: Reduced palmitoylation, reduced cell surface localization but coupling to G protein unaffected. 1 Publication

Keywords - Diseasei

Diabetes insipidus, Disease mutation

Organism-specific databases

MalaCardsiAVPR2.
MIMi300539. phenotype.
304800. phenotype.
Orphaneti83449. Inappropriate antidiuretic hormone secretion syndrome.
223. Nephrogenic diabetes insipidus.
93606. Nephrogenic syndrome of inappropriate antidiuresis.
PharmGKBiPA25189.

Chemistry

ChEMBLiCHEMBL2363078.
DrugBankiDB00872. Conivaptan.
DB00035. Desmopressin.
DB02638. Terlipressin.
DB06212. Tolvaptan.
DB00067. Vasopressin.
GuidetoPHARMACOLOGYi368.

Polymorphism and mutation databases

BioMutaiAVPR2.
DMDMi267256.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 371371Vasopressin V2 receptorPRO_0000070208Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi22 – 221N-linked (GlcNAc...)Sequence analysis
Lipidationi341 – 3411S-palmitoyl cysteine1 Publication
Lipidationi342 – 3421S-palmitoyl cysteine1 Publication

Keywords - PTMi

Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiP30518.
PeptideAtlasiP30518.
PRIDEiP30518.
TopDownProteomicsiP30518-2. [P30518-2]

PTM databases

iPTMnetiP30518.
PhosphoSiteiP30518.
SwissPalmiP30518.

Expressioni

Tissue specificityi

Kidney.

Gene expression databases

BgeeiENSG00000126895.
CleanExiHS_AVPR2.
ExpressionAtlasiP30518. baseline and differential.
GenevisibleiP30518. HS.

Organism-specific databases

HPAiHPA046678.

Interactioni

Subunit structurei

Interacts with ARRDC4. Identified in a complex containing at least ARRDC4, V2R and HGS.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
ARRDC4Q8NCT12EBI-11675746,EBI-11673273

Protein-protein interaction databases

BioGridi107035. 13 interactions.
IntActiP30518. 1 interaction.
STRINGi9606.ENSP00000338072.

Chemistry

BindingDBiP30518.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4JQIX-ray2.60V343-371[»]
ProteinModelPortaliP30518.
SMRiP30518. Positions 36-364.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000119156.
HOGENOMiHOG000237331.
HOVERGENiHBG105710.
InParanoidiP30518.
KOiK04228.
OMAiGGARWNR.
PhylomeDBiP30518.
TreeFamiTF106499.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001817. Vasoprsn_rcpt.
IPR000161. Vprsn_rcpt_V2.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00896. VASOPRESSINR.
PR00898. VASOPRSNV2R.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P30518-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLMASTTSAV PGHPSLPSLP SNSSQERPLD TRDPLLARAE LALLSIVFVA
60 70 80 90 100
VALSNGLVLA ALARRGRRGH WAPIHVFIGH LCLADLAVAL FQVLPQLAWK
110 120 130 140 150
ATDRFRGPDA LCRAVKYLQM VGMYASSYMI LAMTLDRHRA ICRPMLAYRH
160 170 180 190 200
GSGAHWNRPV LVAWAFSLLL SLPQLFIFAQ RNVEGGSGVT DCWACFAEPW
210 220 230 240 250
GRRTYVTWIA LMVFVAPTLG IAACQVLIFR EIHASLVPGP SERPGGRRRG
260 270 280 290 300
RRTGSPGEGA HVSAAVAKTV RMTLVIVVVY VLCWAPFFLV QLWAAWDPEA
310 320 330 340 350
PLEGAPFVLL MLLASLNSCT NPWIYASFSS SVSSELRSLL CCARGRTPPS
360 370
LGPQDESCTT ASSSLAKDTS S
Length:371
Mass (Da):40,279
Last modified:April 1, 1993 - v1
Checksum:i1F87D20A3C0ECB0D
GO
Isoform 2 (identifier: P30518-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     305-309: APFVL → GCSRG
     310-371: Missing.

Show »
Length:309
Mass (Da):33,743
Checksum:iCAB6A8B0A682ED0F
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti7 – 71T → S.
Corresponds to variant rs5196 [ dbSNP | Ensembl ].
VAR_003516
Natural varianti12 – 121G → E.
Corresponds to variant rs2071126 [ dbSNP | Ensembl ].
VAR_015296
Natural varianti42 – 421A → V.
Corresponds to variant rs5198 [ dbSNP | Ensembl ].
VAR_011858
Natural varianti43 – 431L → P in XNDI. 1 Publication
VAR_015297
Natural varianti44 – 441L → P in XNDI. 1 Publication
VAR_003517
Natural varianti46 – 461I → K in XNDI. 1 Publication
Corresponds to variant rs104894759 [ dbSNP | Ensembl ].
VAR_015298
Natural varianti53 – 531L → R in XNDI.
VAR_015299
Natural varianti55 – 551N → D in XNDI.
VAR_015300
Natural varianti55 – 551N → H in XNDI.
VAR_015301
Natural varianti59 – 591L → P in XNDI.
Corresponds to variant rs193922112 [ dbSNP | Ensembl ].
VAR_015302
Natural varianti61 – 611A → V.
VAR_015303
Natural varianti62 – 643Missing in XNDI.
VAR_003518
Natural varianti62 – 621L → P in XNDI.
VAR_015304
Natural varianti64 – 641R → W.
Corresponds to variant rs150351033 [ dbSNP | Ensembl ].
VAR_003519
Natural varianti80 – 801H → R in XNDI. 1 Publication
VAR_003520
Natural varianti81 – 811L → F in XNDI.
VAR_015305
Natural varianti83 – 831L → P in XNDI.
VAR_015306
Natural varianti83 – 831L → Q in XNDI.
VAR_015307
Natural varianti84 – 841A → D in XNDI.
VAR_015308
Natural varianti85 – 851D → N in XNDI.
Corresponds to variant rs104894754 [ dbSNP | Ensembl ].
VAR_015309
Natural varianti88 – 881V → M in XNDI.
VAR_003521
Natural varianti92 – 921Q → R in XNDI.
VAR_015310
Natural varianti94 – 941L → Q in XNDI.
VAR_015311
Natural varianti95 – 951P → L in XNDI.
VAR_015312
Natural varianti99 – 991W → R in XNDI.
VAR_015313
Natural varianti104 – 1041R → C in XNDI; binding capacity is 10% of wild-type, but binding affinity is stronger than wild-type. 1 Publication
Corresponds to variant rs104894760 [ dbSNP | Ensembl ].
VAR_015314
Natural varianti105 – 1051F → V in XNDI. 1 Publication
Corresponds to variant rs104894758 [ dbSNP | Ensembl ].
VAR_015315
Natural varianti106 – 1061R → C in XNDI. 1 Publication
VAR_003522
Natural varianti107 – 1071G → E in XNDI. 1 Publication
VAR_015316
Natural varianti112 – 1121C → R in XNDI. 1 Publication
VAR_003523
Natural varianti112 – 1121C → Y in XNDI.
VAR_015317
Natural varianti113 – 1131R → W in XNDI. 2 Publications
Corresponds to variant rs28935496 [ dbSNP | Ensembl ].
VAR_003524
Natural varianti122 – 1221G → D in XNDI. 1 Publication
VAR_062591
Natural varianti122 – 1221G → R in XNDI.
VAR_015318
Natural varianti123 – 1231M → K in XNDI.
VAR_015319
Natural varianti126 – 1261S → F in XNDI.
VAR_003525
Natural varianti127 – 1271S → F in XNDI.
VAR_015320
Natural varianti128 – 1281Y → S in XNDI. 2 Publications
VAR_003526
Natural varianti130 – 1301I → F in XNDI. 1 Publication
Corresponds to variant rs796052096 [ dbSNP | Ensembl ].
VAR_015321
Natural varianti132 – 1321A → D in XNDI. 1 Publication
Corresponds to variant rs104894747 [ dbSNP | Ensembl ].
VAR_003527
Natural varianti135 – 1351L → P in XNDI.
VAR_015322
Natural varianti137 – 1371R → C in NSIAD; constitutively active. 1 Publication
Corresponds to variant rs104894761 [ dbSNP | Ensembl ].
VAR_025901
Natural varianti137 – 1371R → H in XNDI; fails to activate the adenylyl cyclase system. 4 Publications
Corresponds to variant rs104894756 [ dbSNP | Ensembl ].
VAR_003528
Natural varianti137 – 1371R → L in NSIAD; constitutively active. 1 Publication
Corresponds to variant rs104894756 [ dbSNP | Ensembl ].
VAR_025902
Natural varianti139 – 1391R → S.
VAR_015323
Natural varianti143 – 1431R → P in XNDI. 2 Publications
VAR_003529
Natural varianti147 – 1471A → V.
Corresponds to variant rs5200 [ dbSNP | Ensembl ].
VAR_003530
Natural varianti163 – 1631A → P in XNDI.
VAR_015324
Natural varianti164 – 1641W → S in XNDI.
VAR_003531
Natural varianti167 – 1671S → L in XNDI.
VAR_003532
Natural varianti167 – 1671S → T in XNDI. 1 Publication
VAR_003533
Natural varianti173 – 1731P → S in XNDI.
VAR_015325
Natural varianti174 – 1741Q → L in XNDI.
VAR_015326
Natural varianti181 – 1811R → C in XNDI. 2 Publications
Corresponds to variant rs104894757 [ dbSNP | Ensembl ].
VAR_003534
Natural varianti185 – 1851G → C in XNDI. 1 Publication
Corresponds to variant rs104894748 [ dbSNP | Ensembl ].
VAR_003535
Natural varianti191 – 1911D → G in XNDI.
VAR_015327
Natural varianti201 – 2011G → D in XNDI.
Corresponds to variant rs104894755 [ dbSNP | Ensembl ].
VAR_015328
Natural varianti202 – 2021R → C in XNDI. 1 Publication
Corresponds to variant rs782806507 [ dbSNP | Ensembl ].
VAR_003536
Natural varianti203 – 2031R → C in XNDI. 1 Publication
Corresponds to variant rs104894750 [ dbSNP | Ensembl ].
VAR_003537
Natural varianti204 – 2041T → N in XNDI. 1 Publication
VAR_015329
Natural varianti205 – 2051Y → C in XNDI. 2 Publications
Corresponds to variant rs104894749 [ dbSNP | Ensembl ].
VAR_003538
Natural varianti206 – 2061V → D in XNDI. 1 Publication
VAR_015330
Natural varianti207 – 2071T → N in XNDI.
VAR_015331
Natural varianti209 – 2091I → F in XNDI.
VAR_015332
Natural varianti214 – 2141F → S in XNDI.
VAR_015333
Natural varianti215 – 2151V → M.
Corresponds to variant rs112109182 [ dbSNP | Ensembl ].
VAR_015334
Natural varianti217 – 2171P → T in XNDI.
VAR_015335
Natural varianti219 – 2191L → P in XNDI.
VAR_015336
Natural varianti219 – 2191L → R in XNDI.
VAR_015337
Natural varianti247 – 2504Missing in XNDI. 1 Publication
VAR_003539
Natural varianti247 – 2471R → H in a breast cancer sample; somatic mutation. 1 Publication
Corresponds to variant rs149668713 [ dbSNP | Ensembl ].
VAR_035769
Natural varianti252 – 2521R → W.
Corresponds to variant rs61733407 [ dbSNP | Ensembl ].
VAR_015338
Natural varianti272 – 2721M → K in XNDI.
VAR_015339
Natural varianti277 – 2771V → A in XNDI.
VAR_015340
Natural varianti277 – 2771Missing in CDNI. 4 Publications
VAR_003540
Natural varianti280 – 2801Y → C in XNDI. 2 Publications
Corresponds to variant rs104894752 [ dbSNP | Ensembl ].
VAR_003541
Natural varianti282 – 2821L → P in XNDI.
VAR_015341
Natural varianti285 – 2851A → P in CDNI.
Corresponds to variant rs193922122 [ dbSNP | Ensembl ].
VAR_003542
Natural varianti286 – 2861P → L in XNDI. 1 Publication
VAR_003543
Natural varianti286 – 2861P → R in XNDI. 1 Publication
VAR_003544
Natural varianti286 – 2861P → S in XNDI.
VAR_015342
Natural varianti287 – 2871F → L in XNDI. 1 Publication
VAR_015343
Natural varianti289 – 2891L → P in XNDI.
VAR_015344
Natural varianti292 – 2921L → P in XNDI. 1 Publication
VAR_003545
Natural varianti294 – 2941A → P in XNDI.
VAR_015345
Natural varianti309 – 3091L → P in XNDI. 1 Publication
VAR_003546
Natural varianti309 – 3091L → R in XNDI.
VAR_015346
Natural varianti315 – 3151S → R in XNDI.
VAR_015347
Natural varianti317 – 3171N → K in XNDI. 1 Publication
VAR_003547
Natural varianti318 – 3181S → T.
VAR_015348
Natural varianti319 – 3191C → R in XNDI.
VAR_015349
Natural varianti321 – 3211N → D in XNDI.
VAR_015350
Natural varianti321 – 3211N → K in XNDI.
Corresponds to variant rs193922123 [ dbSNP | Ensembl ].
VAR_015351
Natural varianti321 – 3211N → Y in XNDI.
VAR_015352
Natural varianti322 – 3221P → H in XNDI.
VAR_015353
Natural varianti322 – 3221P → S in XNDI. 1 Publication
VAR_015354
Natural varianti323 – 3231W → R in XNDI.
VAR_015355
Natural varianti323 – 3231W → S in XNDI. 1 Publication
VAR_003548
Natural varianti352 – 3521G → D.
Corresponds to variant rs146350208 [ dbSNP | Ensembl ].
VAR_015356

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei305 – 3095APFVL → GCSRG in isoform 2. 1 PublicationVSP_036990
Alternative sequencei310 – 37162Missing in isoform 2. 1 PublicationVSP_036991Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L22206 Genomic DNA. Translation: AAA03651.1.
Z11687 mRNA. Translation: CAA77746.1.
U04357 Genomic DNA. Translation: AAC09005.1.
AF030626 mRNA. Translation: AAB86428.1.
AF101727 mRNA. Translation: AAD16444.1.
AF032388 mRNA. Translation: AAB87678.1.
AY242131 mRNA. Translation: AAO92298.1.
FJ411207 Genomic DNA. Translation: ACR39021.1.
CH471172 Genomic DNA. Translation: EAW72783.1.
CH471172 Genomic DNA. Translation: EAW72784.1.
CH471172 Genomic DNA. Translation: EAW72785.1.
BC101484 mRNA. Translation: AAI01485.1.
BC112181 mRNA. Translation: AAI12182.1.
CCDSiCCDS14735.1. [P30518-1]
CCDS55539.1. [P30518-2]
PIRiI51865.
RefSeqiNP_000045.1. NM_000054.4. [P30518-1]
NP_001139623.1. NM_001146151.1. [P30518-2]
XP_006724891.1. XM_006724828.3. [P30518-1]
UniGeneiHs.567240.

Genome annotation databases

EnsembliENST00000337474; ENSP00000338072; ENSG00000126895. [P30518-1]
ENST00000358927; ENSP00000351805; ENSG00000126895. [P30518-1]
ENST00000370049; ENSP00000359066; ENSG00000126895. [P30518-2]
GeneIDi554.
KEGGihsa:554.
UCSCiuc004fjh.5. human. [P30518-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Nephrogenic and neurogenic Diabetes Insipidus

AVPR2 pages

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L22206 Genomic DNA. Translation: AAA03651.1.
Z11687 mRNA. Translation: CAA77746.1.
U04357 Genomic DNA. Translation: AAC09005.1.
AF030626 mRNA. Translation: AAB86428.1.
AF101727 mRNA. Translation: AAD16444.1.
AF032388 mRNA. Translation: AAB87678.1.
AY242131 mRNA. Translation: AAO92298.1.
FJ411207 Genomic DNA. Translation: ACR39021.1.
CH471172 Genomic DNA. Translation: EAW72783.1.
CH471172 Genomic DNA. Translation: EAW72784.1.
CH471172 Genomic DNA. Translation: EAW72785.1.
BC101484 mRNA. Translation: AAI01485.1.
BC112181 mRNA. Translation: AAI12182.1.
CCDSiCCDS14735.1. [P30518-1]
CCDS55539.1. [P30518-2]
PIRiI51865.
RefSeqiNP_000045.1. NM_000054.4. [P30518-1]
NP_001139623.1. NM_001146151.1. [P30518-2]
XP_006724891.1. XM_006724828.3. [P30518-1]
UniGeneiHs.567240.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4JQIX-ray2.60V343-371[»]
ProteinModelPortaliP30518.
SMRiP30518. Positions 36-364.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107035. 13 interactions.
IntActiP30518. 1 interaction.
STRINGi9606.ENSP00000338072.

Chemistry

BindingDBiP30518.
ChEMBLiCHEMBL2363078.
DrugBankiDB00872. Conivaptan.
DB00035. Desmopressin.
DB02638. Terlipressin.
DB06212. Tolvaptan.
DB00067. Vasopressin.
GuidetoPHARMACOLOGYi368.

Protein family/group databases

TCDBi9.A.14.10.3. the g-protein-coupled receptor (gpcr) family.
GPCRDBiSearch...

PTM databases

iPTMnetiP30518.
PhosphoSiteiP30518.
SwissPalmiP30518.

Polymorphism and mutation databases

BioMutaiAVPR2.
DMDMi267256.

Proteomic databases

PaxDbiP30518.
PeptideAtlasiP30518.
PRIDEiP30518.
TopDownProteomicsiP30518-2. [P30518-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000337474; ENSP00000338072; ENSG00000126895. [P30518-1]
ENST00000358927; ENSP00000351805; ENSG00000126895. [P30518-1]
ENST00000370049; ENSP00000359066; ENSG00000126895. [P30518-2]
GeneIDi554.
KEGGihsa:554.
UCSCiuc004fjh.5. human. [P30518-1]

Organism-specific databases

CTDi554.
GeneCardsiAVPR2.
GeneReviewsiAVPR2.
HGNCiHGNC:897. AVPR2.
HPAiHPA046678.
MalaCardsiAVPR2.
MIMi300538. gene.
300539. phenotype.
304800. phenotype.
neXtProtiNX_P30518.
Orphaneti83449. Inappropriate antidiuretic hormone secretion syndrome.
223. Nephrogenic diabetes insipidus.
93606. Nephrogenic syndrome of inappropriate antidiuresis.
PharmGKBiPA25189.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000119156.
HOGENOMiHOG000237331.
HOVERGENiHBG105710.
InParanoidiP30518.
KOiK04228.
OMAiGGARWNR.
PhylomeDBiP30518.
TreeFamiTF106499.

Enzyme and pathway databases

ReactomeiR-HSA-388479. Vasopressin-like receptors.
R-HSA-418555. G alpha (s) signalling events.
R-HSA-432040. Vasopressin regulates renal water homeostasis via Aquaporins.
R-HSA-5619099. Defective AVP causes neurohypophyseal diabetes insipidus (NDI).
SignaLinkiP30518.
SIGNORiP30518.

Miscellaneous databases

GeneWikiiArginine_vasopressin_receptor_2.
GenomeRNAii554.
PROiP30518.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000126895.
CleanExiHS_AVPR2.
ExpressionAtlasiP30518. baseline and differential.
GenevisibleiP30518. HS.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001817. Vasoprsn_rcpt.
IPR000161. Vprsn_rcpt_V2.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00896. VASOPRESSINR.
PR00898. VASOPRSNV2R.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiV2R_HUMAN
AccessioniPrimary (citable) accession number: P30518
Secondary accession number(s): C5HF20
, O43192, Q3MJD3, Q9UCV9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: September 7, 2016
This is version 179 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.