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Protein

Vasopressin V2 receptor

Gene

AVPR2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Involved in renal water reabsorption.1 Publication

GO - Molecular functioni

  • peptide binding Source: GO_Central
  • vasopressin receptor activity Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

BioCyciZFISH:ENSG00000126895-MONOMER.
ReactomeiR-HSA-388479. Vasopressin-like receptors.
R-HSA-418555. G alpha (s) signalling events.
R-HSA-432040. Vasopressin regulates renal water homeostasis via Aquaporins.
R-HSA-5619099. Defective AVP causes neurohypophyseal diabetes insipidus (NDI).
R-HSA-8856825. Cargo recognition for clathrin-mediated endocytosis.
R-HSA-8856828. Clathrin-mediated endocytosis.
SignaLinkiP30518.
SIGNORiP30518.

Protein family/group databases

TCDBi9.A.14.10.3. the g-protein-coupled receptor (gpcr) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Vasopressin V2 receptor
Short name:
V2R
Alternative name(s):
AVPR V2
Antidiuretic hormone receptor
Renal-type arginine vasopressin receptor
Gene namesi
Name:AVPR2
Synonyms:ADHR, DIR, DIR3, V2R
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:897. AVPR2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 38ExtracellularSequence analysisAdd BLAST38
Transmembranei39 – 63Helical; Name=1Sequence analysisAdd BLAST25
Topological domaini64 – 77CytoplasmicSequence analysisAdd BLAST14
Transmembranei78 – 98Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini99 – 113ExtracellularSequence analysisAdd BLAST15
Transmembranei114 – 135Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini136 – 159CytoplasmicSequence analysisAdd BLAST24
Transmembranei160 – 180Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini181 – 200ExtracellularSequence analysisAdd BLAST20
Transmembranei201 – 220Helical; Name=5Sequence analysisAdd BLAST20
Topological domaini221 – 271CytoplasmicSequence analysisAdd BLAST51
Transmembranei272 – 293Helical; Name=6Sequence analysisAdd BLAST22
Topological domaini294 – 308ExtracellularSequence analysisAdd BLAST15
Transmembranei309 – 328Helical; Name=7Sequence analysisAdd BLAST20
Topological domaini329 – 371CytoplasmicSequence analysisAdd BLAST43

GO - Cellular componenti

  • endoplasmic reticulum Source: ProtInc
  • endosome Source: ProtInc
  • Golgi apparatus Source: ProtInc
  • integral component of membrane Source: UniProtKB
  • integral component of plasma membrane Source: ProtInc
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Involvement in diseasei

Nephrogenic syndrome of inappropriate antidiuresis (NSIAD)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionCharacterized by an inability to excrete a free water load, with inappropriately concentrated urine and resultant hyponatremia, hypoosmolarity, and natriuresis.
See also OMIM:300539
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_025901137R → C in NSIAD; constitutively active. 1 PublicationCorresponds to variant rs104894761dbSNPEnsembl.1
Natural variantiVAR_025902137R → L in NSIAD; constitutively active. 1 PublicationCorresponds to variant rs104894756dbSNPEnsembl.1
Diabetes insipidus, nephrogenic, X-linked (XNDI)22 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disorder caused by the inability of the renal collecting ducts to absorb water in response to arginine vasopressin. Characterized by excessive water drinking (polydipsia), excessive urine excretion (polyuria), persistent hypotonic urine, and hypokalemia.
See also OMIM:304800
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01529743L → P in XNDI. 1 Publication1
Natural variantiVAR_00351744L → P in XNDI. 1 Publication1
Natural variantiVAR_01529846I → K in XNDI. 1 PublicationCorresponds to variant rs104894759dbSNPEnsembl.1
Natural variantiVAR_01529953L → R in XNDI. 1
Natural variantiVAR_01530055N → D in XNDI. 1
Natural variantiVAR_01530155N → H in XNDI. 1
Natural variantiVAR_01530259L → P in XNDI. Corresponds to variant rs193922112dbSNPEnsembl.1
Natural variantiVAR_00351862 – 64Missing in XNDI. 3
Natural variantiVAR_01530462L → P in XNDI. 1
Natural variantiVAR_00352080H → R in XNDI. 1 Publication1
Natural variantiVAR_01530581L → F in XNDI. 1
Natural variantiVAR_01530683L → P in XNDI. 1
Natural variantiVAR_01530783L → Q in XNDI. 1
Natural variantiVAR_01530884A → D in XNDI. 1
Natural variantiVAR_01530985D → N in XNDI. Corresponds to variant rs104894754dbSNPEnsembl.1
Natural variantiVAR_00352188V → M in XNDI. 1
Natural variantiVAR_01531092Q → R in XNDI. 1
Natural variantiVAR_01531194L → Q in XNDI. 1
Natural variantiVAR_01531295P → L in XNDI. 1
Natural variantiVAR_01531399W → R in XNDI. 1
Natural variantiVAR_015314104R → C in XNDI; binding capacity is 10% of wild-type, but binding affinity is stronger than wild-type. 1 PublicationCorresponds to variant rs104894760dbSNPEnsembl.1
Natural variantiVAR_015315105F → V in XNDI. 1 PublicationCorresponds to variant rs104894758dbSNPEnsembl.1
Natural variantiVAR_003522106R → C in XNDI. 1 Publication1
Natural variantiVAR_015316107G → E in XNDI. 1 Publication1
Natural variantiVAR_003523112C → R in XNDI. 1 Publication1
Natural variantiVAR_015317112C → Y in XNDI. 1
Natural variantiVAR_003524113R → W in XNDI. 2 PublicationsCorresponds to variant rs28935496dbSNPEnsembl.1
Natural variantiVAR_062591122G → D in XNDI. 1 Publication1
Natural variantiVAR_015318122G → R in XNDI. 1
Natural variantiVAR_015319123M → K in XNDI. 1
Natural variantiVAR_003525126S → F in XNDI. 1
Natural variantiVAR_015320127S → F in XNDI. 1
Natural variantiVAR_003526128Y → S in XNDI. 2 Publications1
Natural variantiVAR_015321130I → F in XNDI. 1 PublicationCorresponds to variant rs796052096dbSNPEnsembl.1
Natural variantiVAR_003527132A → D in XNDI. 1 PublicationCorresponds to variant rs104894747dbSNPEnsembl.1
Natural variantiVAR_015322135L → P in XNDI. 1
Natural variantiVAR_003528137R → H in XNDI; fails to activate the adenylyl cyclase system. 4 PublicationsCorresponds to variant rs104894756dbSNPEnsembl.1
Natural variantiVAR_003529143R → P in XNDI. 2 Publications1
Natural variantiVAR_015324163A → P in XNDI. 1
Natural variantiVAR_003531164W → S in XNDI. 1
Natural variantiVAR_003532167S → L in XNDI. 1
Natural variantiVAR_003533167S → T in XNDI. 1 Publication1
Natural variantiVAR_015325173P → S in XNDI. 1
Natural variantiVAR_015326174Q → L in XNDI. 1
Natural variantiVAR_003534181R → C in XNDI. 2 PublicationsCorresponds to variant rs104894757dbSNPEnsembl.1
Natural variantiVAR_003535185G → C in XNDI. 1 PublicationCorresponds to variant rs104894748dbSNPEnsembl.1
Natural variantiVAR_015327191D → G in XNDI. 1
Natural variantiVAR_015328201G → D in XNDI. Corresponds to variant rs104894755dbSNPEnsembl.1
Natural variantiVAR_003536202R → C in XNDI. 1 PublicationCorresponds to variant rs782806507dbSNPEnsembl.1
Natural variantiVAR_003537203R → C in XNDI. 1 PublicationCorresponds to variant rs104894750dbSNPEnsembl.1
Natural variantiVAR_015329204T → N in XNDI. 1 Publication1
Natural variantiVAR_003538205Y → C in XNDI. 2 PublicationsCorresponds to variant rs104894749dbSNPEnsembl.1
Natural variantiVAR_015330206V → D in XNDI. 1 Publication1
Natural variantiVAR_015331207T → N in XNDI. 1
Natural variantiVAR_015332209I → F in XNDI. 1
Natural variantiVAR_015333214F → S in XNDI. 1
Natural variantiVAR_015335217P → T in XNDI. 1
Natural variantiVAR_015336219L → P in XNDI. 1
Natural variantiVAR_015337219L → R in XNDI. 1
Natural variantiVAR_003539247 – 250Missing in XNDI. 1 Publication4
Natural variantiVAR_015339272M → K in XNDI. 1
Natural variantiVAR_015340277V → A in XNDI. 1
Natural variantiVAR_003541280Y → C in XNDI. 2 PublicationsCorresponds to variant rs104894752dbSNPEnsembl.1
Natural variantiVAR_015341282L → P in XNDI. 1
Natural variantiVAR_003543286P → L in XNDI. 1 Publication1
Natural variantiVAR_003544286P → R in XNDI. 1 Publication1
Natural variantiVAR_015342286P → S in XNDI. 1
Natural variantiVAR_015343287F → L in XNDI. 1 Publication1
Natural variantiVAR_015344289L → P in XNDI. 1
Natural variantiVAR_003545292L → P in XNDI. 1 Publication1
Natural variantiVAR_015345294A → P in XNDI. 1
Natural variantiVAR_003546309L → P in XNDI. 1 Publication1
Natural variantiVAR_015346309L → R in XNDI. 1
Natural variantiVAR_015347315S → R in XNDI. 1
Natural variantiVAR_003547317N → K in XNDI. 1 Publication1
Natural variantiVAR_015349319C → R in XNDI. 1
Natural variantiVAR_015350321N → D in XNDI. 1
Natural variantiVAR_015351321N → K in XNDI. Corresponds to variant rs193922123dbSNPEnsembl.1
Natural variantiVAR_015352321N → Y in XNDI. 1
Natural variantiVAR_015353322P → H in XNDI. 1
Natural variantiVAR_015354322P → S in XNDI. 1 Publication1
Natural variantiVAR_015355323W → R in XNDI. 1
Natural variantiVAR_003548323W → S in XNDI. 1 Publication1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi341C → S: Reduced palmitoylation, reduced cell surface localization but coupling to G protein unaffected. 1 Publication1
Mutagenesisi342C → S: Reduced palmitoylation, reduced cell surface localization but coupling to G protein unaffected. 1 Publication1

Keywords - Diseasei

Diabetes insipidus, Disease mutation

Organism-specific databases

DisGeNETi554.
MalaCardsiAVPR2.
MIMi300539. phenotype.
304800. phenotype.
OpenTargetsiENSG00000126895.
Orphaneti83449. Inappropriate antidiuretic hormone secretion syndrome.
223. Nephrogenic diabetes insipidus.
93606. Nephrogenic syndrome of inappropriate antidiuresis.
PharmGKBiPA25189.

Chemistry databases

ChEMBLiCHEMBL1790.
DrugBankiDB00872. Conivaptan.
DB00035. Desmopressin.
DB02638. Terlipressin.
DB06212. Tolvaptan.
DB00067. Vasopressin.
GuidetoPHARMACOLOGYi368.

Polymorphism and mutation databases

BioMutaiAVPR2.
DMDMi267256.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000702081 – 371Vasopressin V2 receptorAdd BLAST371

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi22N-linked (GlcNAc...)Sequence analysis1
Lipidationi341S-palmitoyl cysteine1 Publication1
Lipidationi342S-palmitoyl cysteine1 Publication1

Keywords - PTMi

Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiP30518.
PeptideAtlasiP30518.
PRIDEiP30518.
TopDownProteomicsiP30518-2. [P30518-2]

PTM databases

iPTMnetiP30518.
PhosphoSitePlusiP30518.
SwissPalmiP30518.

Expressioni

Tissue specificityi

Kidney.

Gene expression databases

BgeeiENSG00000126895.
CleanExiHS_AVPR2.
ExpressionAtlasiP30518. baseline and differential.
GenevisibleiP30518. HS.

Organism-specific databases

HPAiHPA046678.

Interactioni

Subunit structurei

Interacts with ARRDC4. Identified in a complex containing at least ARRDC4, V2R and HGS.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
ARRDC4Q8NCT12EBI-11675746,EBI-11673273

Protein-protein interaction databases

BioGridi107035. 13 interactors.
IntActiP30518. 1 interactor.
STRINGi9606.ENSP00000338072.

Chemistry databases

BindingDBiP30518.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4JQIX-ray2.60V343-371[»]
ProteinModelPortaliP30518.
SMRiP30518.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000119156.
HOGENOMiHOG000237331.
HOVERGENiHBG105710.
InParanoidiP30518.
KOiK04228.
OMAiGGARWNR.
PhylomeDBiP30518.
TreeFamiTF106499.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001817. Vasoprsn_rcpt.
IPR000161. Vprsn_rcpt_V2.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00896. VASOPRESSINR.
PR00898. VASOPRSNV2R.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P30518-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLMASTTSAV PGHPSLPSLP SNSSQERPLD TRDPLLARAE LALLSIVFVA
60 70 80 90 100
VALSNGLVLA ALARRGRRGH WAPIHVFIGH LCLADLAVAL FQVLPQLAWK
110 120 130 140 150
ATDRFRGPDA LCRAVKYLQM VGMYASSYMI LAMTLDRHRA ICRPMLAYRH
160 170 180 190 200
GSGAHWNRPV LVAWAFSLLL SLPQLFIFAQ RNVEGGSGVT DCWACFAEPW
210 220 230 240 250
GRRTYVTWIA LMVFVAPTLG IAACQVLIFR EIHASLVPGP SERPGGRRRG
260 270 280 290 300
RRTGSPGEGA HVSAAVAKTV RMTLVIVVVY VLCWAPFFLV QLWAAWDPEA
310 320 330 340 350
PLEGAPFVLL MLLASLNSCT NPWIYASFSS SVSSELRSLL CCARGRTPPS
360 370
LGPQDESCTT ASSSLAKDTS S
Length:371
Mass (Da):40,279
Last modified:April 1, 1993 - v1
Checksum:i1F87D20A3C0ECB0D
GO
Isoform 2 (identifier: P30518-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     305-309: APFVL → GCSRG
     310-371: Missing.

Show »
Length:309
Mass (Da):33,743
Checksum:iCAB6A8B0A682ED0F
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0035167T → S.Corresponds to variant rs5196dbSNPEnsembl.1
Natural variantiVAR_01529612G → E.Corresponds to variant rs2071126dbSNPEnsembl.1
Natural variantiVAR_01185842A → V.Corresponds to variant rs5198dbSNPEnsembl.1
Natural variantiVAR_01529743L → P in XNDI. 1 Publication1
Natural variantiVAR_00351744L → P in XNDI. 1 Publication1
Natural variantiVAR_01529846I → K in XNDI. 1 PublicationCorresponds to variant rs104894759dbSNPEnsembl.1
Natural variantiVAR_01529953L → R in XNDI. 1
Natural variantiVAR_01530055N → D in XNDI. 1
Natural variantiVAR_01530155N → H in XNDI. 1
Natural variantiVAR_01530259L → P in XNDI. Corresponds to variant rs193922112dbSNPEnsembl.1
Natural variantiVAR_01530361A → V.1
Natural variantiVAR_00351862 – 64Missing in XNDI. 3
Natural variantiVAR_01530462L → P in XNDI. 1
Natural variantiVAR_00351964R → W.Corresponds to variant rs150351033dbSNPEnsembl.1
Natural variantiVAR_00352080H → R in XNDI. 1 Publication1
Natural variantiVAR_01530581L → F in XNDI. 1
Natural variantiVAR_01530683L → P in XNDI. 1
Natural variantiVAR_01530783L → Q in XNDI. 1
Natural variantiVAR_01530884A → D in XNDI. 1
Natural variantiVAR_01530985D → N in XNDI. Corresponds to variant rs104894754dbSNPEnsembl.1
Natural variantiVAR_00352188V → M in XNDI. 1
Natural variantiVAR_01531092Q → R in XNDI. 1
Natural variantiVAR_01531194L → Q in XNDI. 1
Natural variantiVAR_01531295P → L in XNDI. 1
Natural variantiVAR_01531399W → R in XNDI. 1
Natural variantiVAR_015314104R → C in XNDI; binding capacity is 10% of wild-type, but binding affinity is stronger than wild-type. 1 PublicationCorresponds to variant rs104894760dbSNPEnsembl.1
Natural variantiVAR_015315105F → V in XNDI. 1 PublicationCorresponds to variant rs104894758dbSNPEnsembl.1
Natural variantiVAR_003522106R → C in XNDI. 1 Publication1
Natural variantiVAR_015316107G → E in XNDI. 1 Publication1
Natural variantiVAR_003523112C → R in XNDI. 1 Publication1
Natural variantiVAR_015317112C → Y in XNDI. 1
Natural variantiVAR_003524113R → W in XNDI. 2 PublicationsCorresponds to variant rs28935496dbSNPEnsembl.1
Natural variantiVAR_062591122G → D in XNDI. 1 Publication1
Natural variantiVAR_015318122G → R in XNDI. 1
Natural variantiVAR_015319123M → K in XNDI. 1
Natural variantiVAR_003525126S → F in XNDI. 1
Natural variantiVAR_015320127S → F in XNDI. 1
Natural variantiVAR_003526128Y → S in XNDI. 2 Publications1
Natural variantiVAR_015321130I → F in XNDI. 1 PublicationCorresponds to variant rs796052096dbSNPEnsembl.1
Natural variantiVAR_003527132A → D in XNDI. 1 PublicationCorresponds to variant rs104894747dbSNPEnsembl.1
Natural variantiVAR_015322135L → P in XNDI. 1
Natural variantiVAR_025901137R → C in NSIAD; constitutively active. 1 PublicationCorresponds to variant rs104894761dbSNPEnsembl.1
Natural variantiVAR_003528137R → H in XNDI; fails to activate the adenylyl cyclase system. 4 PublicationsCorresponds to variant rs104894756dbSNPEnsembl.1
Natural variantiVAR_025902137R → L in NSIAD; constitutively active. 1 PublicationCorresponds to variant rs104894756dbSNPEnsembl.1
Natural variantiVAR_015323139R → S.1
Natural variantiVAR_003529143R → P in XNDI. 2 Publications1
Natural variantiVAR_003530147A → V.Corresponds to variant rs5200dbSNPEnsembl.1
Natural variantiVAR_015324163A → P in XNDI. 1
Natural variantiVAR_003531164W → S in XNDI. 1
Natural variantiVAR_003532167S → L in XNDI. 1
Natural variantiVAR_003533167S → T in XNDI. 1 Publication1
Natural variantiVAR_015325173P → S in XNDI. 1
Natural variantiVAR_015326174Q → L in XNDI. 1
Natural variantiVAR_003534181R → C in XNDI. 2 PublicationsCorresponds to variant rs104894757dbSNPEnsembl.1
Natural variantiVAR_003535185G → C in XNDI. 1 PublicationCorresponds to variant rs104894748dbSNPEnsembl.1
Natural variantiVAR_015327191D → G in XNDI. 1
Natural variantiVAR_015328201G → D in XNDI. Corresponds to variant rs104894755dbSNPEnsembl.1
Natural variantiVAR_003536202R → C in XNDI. 1 PublicationCorresponds to variant rs782806507dbSNPEnsembl.1
Natural variantiVAR_003537203R → C in XNDI. 1 PublicationCorresponds to variant rs104894750dbSNPEnsembl.1
Natural variantiVAR_015329204T → N in XNDI. 1 Publication1
Natural variantiVAR_003538205Y → C in XNDI. 2 PublicationsCorresponds to variant rs104894749dbSNPEnsembl.1
Natural variantiVAR_015330206V → D in XNDI. 1 Publication1
Natural variantiVAR_015331207T → N in XNDI. 1
Natural variantiVAR_015332209I → F in XNDI. 1
Natural variantiVAR_015333214F → S in XNDI. 1
Natural variantiVAR_015334215V → M.Corresponds to variant rs112109182dbSNPEnsembl.1
Natural variantiVAR_015335217P → T in XNDI. 1
Natural variantiVAR_015336219L → P in XNDI. 1
Natural variantiVAR_015337219L → R in XNDI. 1
Natural variantiVAR_003539247 – 250Missing in XNDI. 1 Publication4
Natural variantiVAR_035769247R → H in a breast cancer sample; somatic mutation. 1 PublicationCorresponds to variant rs149668713dbSNPEnsembl.1
Natural variantiVAR_015338252R → W.Corresponds to variant rs61733407dbSNPEnsembl.1
Natural variantiVAR_015339272M → K in XNDI. 1
Natural variantiVAR_015340277V → A in XNDI. 1
Natural variantiVAR_003540277Missing in CDNI. 4 Publications1
Natural variantiVAR_003541280Y → C in XNDI. 2 PublicationsCorresponds to variant rs104894752dbSNPEnsembl.1
Natural variantiVAR_015341282L → P in XNDI. 1
Natural variantiVAR_003542285A → P in CDNI. Corresponds to variant rs193922122dbSNPEnsembl.1
Natural variantiVAR_003543286P → L in XNDI. 1 Publication1
Natural variantiVAR_003544286P → R in XNDI. 1 Publication1
Natural variantiVAR_015342286P → S in XNDI. 1
Natural variantiVAR_015343287F → L in XNDI. 1 Publication1
Natural variantiVAR_015344289L → P in XNDI. 1
Natural variantiVAR_003545292L → P in XNDI. 1 Publication1
Natural variantiVAR_015345294A → P in XNDI. 1
Natural variantiVAR_003546309L → P in XNDI. 1 Publication1
Natural variantiVAR_015346309L → R in XNDI. 1
Natural variantiVAR_015347315S → R in XNDI. 1
Natural variantiVAR_003547317N → K in XNDI. 1 Publication1
Natural variantiVAR_015348318S → T.1
Natural variantiVAR_015349319C → R in XNDI. 1
Natural variantiVAR_015350321N → D in XNDI. 1
Natural variantiVAR_015351321N → K in XNDI. Corresponds to variant rs193922123dbSNPEnsembl.1
Natural variantiVAR_015352321N → Y in XNDI. 1
Natural variantiVAR_015353322P → H in XNDI. 1
Natural variantiVAR_015354322P → S in XNDI. 1 Publication1
Natural variantiVAR_015355323W → R in XNDI. 1
Natural variantiVAR_003548323W → S in XNDI. 1 Publication1
Natural variantiVAR_015356352G → D.Corresponds to variant rs146350208dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_036990305 – 309APFVL → GCSRG in isoform 2. 1 Publication5
Alternative sequenceiVSP_036991310 – 371Missing in isoform 2. 1 PublicationAdd BLAST62

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L22206 Genomic DNA. Translation: AAA03651.1.
Z11687 mRNA. Translation: CAA77746.1.
U04357 Genomic DNA. Translation: AAC09005.1.
AF030626 mRNA. Translation: AAB86428.1.
AF101727 mRNA. Translation: AAD16444.1.
AF032388 mRNA. Translation: AAB87678.1.
AY242131 mRNA. Translation: AAO92298.1.
FJ411207 Genomic DNA. Translation: ACR39021.1.
CH471172 Genomic DNA. Translation: EAW72783.1.
CH471172 Genomic DNA. Translation: EAW72784.1.
CH471172 Genomic DNA. Translation: EAW72785.1.
BC101484 mRNA. Translation: AAI01485.1.
BC112181 mRNA. Translation: AAI12182.1.
CCDSiCCDS14735.1. [P30518-1]
CCDS55539.1. [P30518-2]
PIRiI51865.
RefSeqiNP_000045.1. NM_000054.4. [P30518-1]
NP_001139623.1. NM_001146151.1. [P30518-2]
XP_006724891.1. XM_006724828.3. [P30518-1]
UniGeneiHs.567240.

Genome annotation databases

EnsembliENST00000337474; ENSP00000338072; ENSG00000126895. [P30518-1]
ENST00000358927; ENSP00000351805; ENSG00000126895. [P30518-1]
ENST00000370049; ENSP00000359066; ENSG00000126895. [P30518-2]
GeneIDi554.
KEGGihsa:554.
UCSCiuc004fjh.5. human. [P30518-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L22206 Genomic DNA. Translation: AAA03651.1.
Z11687 mRNA. Translation: CAA77746.1.
U04357 Genomic DNA. Translation: AAC09005.1.
AF030626 mRNA. Translation: AAB86428.1.
AF101727 mRNA. Translation: AAD16444.1.
AF032388 mRNA. Translation: AAB87678.1.
AY242131 mRNA. Translation: AAO92298.1.
FJ411207 Genomic DNA. Translation: ACR39021.1.
CH471172 Genomic DNA. Translation: EAW72783.1.
CH471172 Genomic DNA. Translation: EAW72784.1.
CH471172 Genomic DNA. Translation: EAW72785.1.
BC101484 mRNA. Translation: AAI01485.1.
BC112181 mRNA. Translation: AAI12182.1.
CCDSiCCDS14735.1. [P30518-1]
CCDS55539.1. [P30518-2]
PIRiI51865.
RefSeqiNP_000045.1. NM_000054.4. [P30518-1]
NP_001139623.1. NM_001146151.1. [P30518-2]
XP_006724891.1. XM_006724828.3. [P30518-1]
UniGeneiHs.567240.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4JQIX-ray2.60V343-371[»]
ProteinModelPortaliP30518.
SMRiP30518.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107035. 13 interactors.
IntActiP30518. 1 interactor.
STRINGi9606.ENSP00000338072.

Chemistry databases

BindingDBiP30518.
ChEMBLiCHEMBL1790.
DrugBankiDB00872. Conivaptan.
DB00035. Desmopressin.
DB02638. Terlipressin.
DB06212. Tolvaptan.
DB00067. Vasopressin.
GuidetoPHARMACOLOGYi368.

Protein family/group databases

TCDBi9.A.14.10.3. the g-protein-coupled receptor (gpcr) family.
GPCRDBiSearch...

PTM databases

iPTMnetiP30518.
PhosphoSitePlusiP30518.
SwissPalmiP30518.

Polymorphism and mutation databases

BioMutaiAVPR2.
DMDMi267256.

Proteomic databases

PaxDbiP30518.
PeptideAtlasiP30518.
PRIDEiP30518.
TopDownProteomicsiP30518-2. [P30518-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000337474; ENSP00000338072; ENSG00000126895. [P30518-1]
ENST00000358927; ENSP00000351805; ENSG00000126895. [P30518-1]
ENST00000370049; ENSP00000359066; ENSG00000126895. [P30518-2]
GeneIDi554.
KEGGihsa:554.
UCSCiuc004fjh.5. human. [P30518-1]

Organism-specific databases

CTDi554.
DisGeNETi554.
GeneCardsiAVPR2.
GeneReviewsiAVPR2.
HGNCiHGNC:897. AVPR2.
HPAiHPA046678.
MalaCardsiAVPR2.
MIMi300538. gene.
300539. phenotype.
304800. phenotype.
neXtProtiNX_P30518.
OpenTargetsiENSG00000126895.
Orphaneti83449. Inappropriate antidiuretic hormone secretion syndrome.
223. Nephrogenic diabetes insipidus.
93606. Nephrogenic syndrome of inappropriate antidiuresis.
PharmGKBiPA25189.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000119156.
HOGENOMiHOG000237331.
HOVERGENiHBG105710.
InParanoidiP30518.
KOiK04228.
OMAiGGARWNR.
PhylomeDBiP30518.
TreeFamiTF106499.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000126895-MONOMER.
ReactomeiR-HSA-388479. Vasopressin-like receptors.
R-HSA-418555. G alpha (s) signalling events.
R-HSA-432040. Vasopressin regulates renal water homeostasis via Aquaporins.
R-HSA-5619099. Defective AVP causes neurohypophyseal diabetes insipidus (NDI).
R-HSA-8856825. Cargo recognition for clathrin-mediated endocytosis.
R-HSA-8856828. Clathrin-mediated endocytosis.
SignaLinkiP30518.
SIGNORiP30518.

Miscellaneous databases

GeneWikiiArginine_vasopressin_receptor_2.
GenomeRNAii554.
PROiP30518.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000126895.
CleanExiHS_AVPR2.
ExpressionAtlasiP30518. baseline and differential.
GenevisibleiP30518. HS.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001817. Vasoprsn_rcpt.
IPR000161. Vprsn_rcpt_V2.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00896. VASOPRESSINR.
PR00898. VASOPRSNV2R.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiV2R_HUMAN
AccessioniPrimary (citable) accession number: P30518
Secondary accession number(s): C5HF20
, O43192, Q3MJD3, Q9UCV9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: November 2, 2016
This is version 181 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.