P30512 (1A29_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
HLA class I histocompatibility antigen, A-29 alpha chain

Alternative name(s):
Aw-19
MHC class I antigen A*29

Gene names

Name:	HLA-A
Synonyms:	HLAA

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	365 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Involved in the presentation of foreign antigens to the immune system.
Subunit structure	Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8 MIR1 protein By similarity.
Subcellular location	Membrane; Single-pass type I membrane protein.
Post-translational modification	Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein. This targets the protein for rapid degradation via the ubiquitin system By similarity.
Polymorphism	The following alleles of A-29 are known: A*29:01 (A29.1), A*29:02 (A29.2), A*29:03 and A*29:04. The sequence shown is that of A*29:01.
Sequence similarities	Belongs to the MHC class I family. Contains 1 Ig-like C1-type (immunoglobulin-like) domain.

Ontologies

Keywords
Biological process	Host-virus interaction Immunity
Cellular component	MHC I Membrane
Coding sequence diversity	Polymorphism
Domain	Signal Transmembrane Transmembrane helix
PTM	Disulfide bond Glycoprotein Ubl conjugation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	antigen processing and presentation of peptide antigen via MHC class I Inferred from electronic annotation. Source: UniProtKB-KW immune response Inferred from electronic annotation. Source: InterPro virus-host interaction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	MHC class I protein complex Inferred from electronic annotation. Source: UniProtKB-KW integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 24	24
	Chain	25 – 365	341	HLA class I histocompatibility antigen, A-29 alpha chain		PRO_0000018821
Regions
	Topological domain	25 – 308	284	Extracellular Potential
	Transmembrane	309 – 332	24	Helical; Potential
	Topological domain	333 – 365	33	Cytoplasmic Potential
	Domain	209 – 295	87	Ig-like C1-type
	Region	25 – 114	90	Alpha-1
	Region	115 – 206	92	Alpha-2
	Region	207 – 298	92	Alpha-3
	Region	299 – 308	10	Connecting peptide
Amino acid modifications
	Glycosylation	110	1	N-linked (GlcNAc...) By similarity
	Disulfide bond	125 ↔ 188		By similarity
	Disulfide bond	227 ↔ 283		By similarity
Natural variations
	Natural variant	90	1	N → H in allele A*29:04.		VAR_016347
	Natural variant	126	1	H → D in allele A*29:02, allele A*29:03 and allele A*29:04.		VAR_004365
	Natural variant	129	1	S → P. Corresponds to variant rs1136700 [ dbSNP | Ensembl ].		VAR_056266
	Natural variant	131	1	G → W. Corresponds to variant rs1136702 [ dbSNP | Ensembl ].		VAR_056267
	Natural variant	133	1	F → L. Corresponds to variant rs1059488 [ dbSNP | Ensembl ].		VAR_056268
	Natural variant	151	1	N → K. Corresponds to variant rs1059509 [ dbSNP | Ensembl ].		VAR_056269
	Natural variant	166	1	I → T. Corresponds to variant rs1059516 [ dbSNP | Ensembl ].		VAR_056270
	Natural variant	190 – 191	2	EW → DG in allele A*29:03.		VAR_010372

Sequences

	Sequence		Length	Mass (Da)
	P30512 [UniParc]. Last modified July 15, 1998. Version 2. Checksum: 56E4B9039B3C783C	FASTA	365	40,863
	10 20 30 40 50 60 MAVMAPRTLL LLLLGALALT QTWAGSHSMR YFTTSVSRPG RGEPRFIAVG YVDDTQFVRF 70 80 90 100 110 120 DSDAASQRME PRAPWIEQEG PEYWDLQTRN VKAQSQTDRA NLGTLRGYYN QSEAGSHTIQ 130 140 150 160 170 180 MMYGCHVGSD GRFLRGYRQD AYDGKDYIAL NEDLRSWTAA DMAAQITQRK WEAARVAEQL 190 200 210 220 230 240 RAYLEGTCVE WLRRYLENGK ETLQRTDAPK THMTHHAVSD HEATLRCWAL SFYPAEITLT 250 260 270 280 290 300 WQRDGEDQTQ DTELVETRPA GDGTFQKWAS VVVPSGQEQR YTCHVQHEGL PKPLTLRWEP 310 320 330 340 350 360 SSQPTIPIVG IIAGLVLFGA VFAGAVVAAV RWRRKSSDRK GGSYSQAASS DSAQGSDMSL TACKV

References

[1]	"Molecular mapping of a new public HLA class I epitope shared by all HLA-B and HLA-C antigens and defined by a monoclonal antibody." Trapani J.A., Mizuno S., Kang S.H., Yang S.Y., Dupont B. Immunogenetics 29:25-32(1989) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE A*29:01).
[2]	Yang S.Y. Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases Cited for: SEQUENCE REVISION TO 345.
[3]	Szmania S., Baxter-Lowe L.A. Submitted (JUN-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE (ALLELE A*29:01).
[4]	"HLA-A29 sub-types and 'Birdshot' choroido-retinopathy susceptibility: a possible 'resistance motif' in the HLA-A29.1 molecule." Tabary T., Prochnicka-Chalufour A., Cornillet P., Lehoang P., Betuel H., Cohen H.M. C. R. Acad. Sci. III, Sci. Vie 313:599-605(1991) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE A*29:02).
[5]	"HLA-A*2903 expresses an epitope shared with HLA-A*8001." Prokupek B., Dunn P., Ross J., Jordan F., Holman R., Madrigal J.A., Little A.-M. Tissue Antigens 51:115-118(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ALLELE A*29:03).
[6]	"Non-conservative substitutions distinguish previously uncharacterized HLA-A molecules." Hickman H.D., Cavett J.W., Ellexson-Turner M.E., Sparkman J.N., Bennett T.T., Turner S., Sidebottom D.A., Trachtenberg E.A., Confer D.L., Hildebrand W.H. Tissue Antigens 57:95-102(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE OF 26-206 (ALLELE A*29:04).
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M23739 mRNA. Translation: AAB47873.1. U83415 mRNA. Translation: AAB53373.1. X60108 mRNA. Translation: CAA42702.1. AJ000661 mRNA. Translation: CAA04209.1. Y09218 Genomic DNA. Translation: CAA70419.1. AH007203 Genomic DNA. Translation: AAD02224.1.
IPI	IPI00472921.
PIR	A45847.
UniGene	Hs.181244. Hs.713441.
3D structure databases
ProteinModelPortal	P30512.
ModBase	Search...
Protein-protein interaction databases
IntAct	P30512. 6 interactions.
Polymorphism databases
DMDM	2851401.
Proteomic databases
PRIDE	P30512.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000456012; ENSP00000408986; ENSG00000231834.
Organism-specific databases
GeneCards	GC06P029933. GC06Pl29898.
HGNC	HGNC:4931. HLA-A.
MIM	142800. gene.
neXtProt	NX_P30512.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	HBG016709.
OrthoDB	EOG4F4SBG.
Gene expression databases
ArrayExpress	P30512.
CleanEx	HS_HLA-A.
Genevestigator	P30512.
GermOnline	ENSG00000204632. Homo sapiens.
Family and domain databases
Gene3D	2.60.40.10. 1 hit. 3.30.500.10. 1 hit.
InterPro	IPR007110. Ig-like_dom. IPR013783. Ig-like_fold. IPR003006. Ig/MHC_CS. IPR003597. Ig_C1-set. IPR011161. MHC_I-like_Ag-recog. IPR011162. MHC_I/II-like_Ag-recog. IPR001039. MHC_I_a_a1/a2. IPR010579. MHC_I_a_C. [Graphical view]
Pfam	PF07654. C1-set. 1 hit. PF00129. MHC_I. 1 hit. PF06623. MHC_I_C. 1 hit. [Graphical view]
PRINTS	PR01638. MHCCLASSI.
SMART	SM00407. IGc1. 1 hit. [Graphical view]
SUPFAM	SSF54452. MHC_I/II-like_Ag-recog. 1 hit.
PROSITE	PS50835. IG_LIKE. 1 hit. PS00290. IG_MHC. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	HLA-A. human.
SOURCE	Search...

Entry information

Entry name

1A29_HUMAN

Accession

Primary (citable) accession number: P30512
Secondary accession number(s): O02955 , O19687, O98011, P30451, P79562

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 1, 1993
Last sequence update:	July 15, 1998
Last modified:	May 1, 2013
This is version 118 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.