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Protein

HLA class I histocompatibility antigen, alpha chain F

Gene

HLA-F

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in the presentation of foreign antigens to the immune system.

GO - Molecular functioni

  • peptide antigen binding Source: GO_Central
  • signaling receptor binding Source: GO_Central
  • TAP1 binding Source: UniProtKB
  • TAP2 binding Source: UniProtKB

GO - Biological processi

Keywordsi

Biological processImmunity

Enzyme and pathway databases

ReactomeiR-HSA-1236974 ER-Phagosome pathway
R-HSA-1236977 Endosomal/Vacuolar pathway
R-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
R-HSA-877300 Interferon gamma signaling
R-HSA-909733 Interferon alpha/beta signaling
R-HSA-983170 Antigen Presentation: Folding, assembly and peptide loading of class I MHC
SIGNORiP30511

Names & Taxonomyi

Protein namesi
Recommended name:
HLA class I histocompatibility antigen, alpha chain F
Alternative name(s):
CDA12
HLA F antigen
Leukocyte antigen F
MHC class I antigen F
Gene namesi
Name:HLA-F
Synonyms:HLA-5.4, HLAF
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000204642.13
HGNCiHGNC:4963 HLA-F
MIMi143110 gene
neXtProtiNX_P30511

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini22 – 305ExtracellularSequence analysisAdd BLAST284
Transmembranei306 – 329HelicalSequence analysisAdd BLAST24
Topological domaini330 – 346CytoplasmicSequence analysisAdd BLAST17

Keywords - Cellular componenti

Membrane, MHC I

Pathology & Biotechi

Organism-specific databases

DisGeNETi3134
OpenTargetsiENSG00000204642
PharmGKBiPA35082

Polymorphism and mutation databases

BioMutaiHLA-F
DMDMi317373438

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Add BLAST21
ChainiPRO_000001888422 – 346HLA class I histocompatibility antigen, alpha chain FAdd BLAST325

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi107N-linked (GlcNAc...) asparagineBy similarity1
Disulfide bondi122 ↔ 185PROSITE-ProRule annotation
Disulfide bondi224 ↔ 280PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP30511
PeptideAtlasiP30511
PRIDEiP30511

PTM databases

iPTMnetiP30511
PhosphoSitePlusiP30511

Expressioni

Gene expression databases

BgeeiENSG00000204642
CleanExiHS_HLA-F
ExpressionAtlasiP30511 baseline and differential
GenevisibleiP30511 HS

Interactioni

Subunit structurei

Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin).

Binary interactionsi

Show more details

GO - Molecular functioni

  • signaling receptor binding Source: GO_Central
  • TAP1 binding Source: UniProtKB
  • TAP2 binding Source: UniProtKB

Protein-protein interaction databases

BioGridi109379, 20 interactors
IntActiP30511, 11 interactors
STRINGi9606.ENSP00000259951

Structurei

Secondary structure

1346
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi24 – 35Combined sources12
Turni36 – 38Combined sources3
Beta strandi39 – 49Combined sources11
Beta strandi52 – 58Combined sources7
Beta strandi61 – 63Combined sources3
Beta strandi67 – 70Combined sources4
Helixi71 – 73Combined sources3
Helixi78 – 105Combined sources28
Beta strandi115 – 124Combined sources10
Beta strandi128 – 139Combined sources12
Beta strandi142 – 147Combined sources6
Beta strandi154 – 158Combined sources5
Helixi161 – 170Combined sources10
Helixi173 – 182Combined sources10
Helixi184 – 195Combined sources12
Helixi197 – 200Combined sources4
Beta strandi207 – 214Combined sources8
Beta strandi216 – 232Combined sources17
Beta strandi235 – 240Combined sources6
Turni246 – 248Combined sources3
Beta strandi249 – 251Combined sources3
Beta strandi258 – 260Combined sources3
Beta strandi262 – 271Combined sources10
Helixi275 – 277Combined sources3
Beta strandi278 – 283Combined sources6
Beta strandi287 – 289Combined sources3
Beta strandi291 – 293Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5IUEX-ray2.62A/E/G/I22-305[»]
5KNMX-ray3.30A22-305[»]
ProteinModelPortaliP30511
SMRiP30511
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini206 – 296Ig-like C1-typeAdd BLAST91

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni22 – 111Alpha-1Add BLAST90
Regioni112 – 203Alpha-2Add BLAST92
Regioni204 – 295Alpha-3Add BLAST92
Regioni296 – 305Connecting peptide10

Sequence similaritiesi

Belongs to the MHC class I family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IUXN Eukaryota
ENOG4111K8F LUCA
GeneTreeiENSGT00760000118960
HOGENOMiHOG000296917
HOVERGENiHBG016709
InParanoidiP30511
KOiK06751
OMAiRITQRFY
PhylomeDBiP30511
TreeFamiTF336617

Family and domain databases

Gene3Di2.60.40.10, 1 hit
3.30.500.10, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003006 Ig/MHC_CS
IPR003597 Ig_C1-set
IPR011161 MHC_I-like_Ag-recog
IPR037055 MHC_I-like_Ag-recog_sf
IPR011162 MHC_I/II-like_Ag-recog
IPR001039 MHC_I_a_a1/a2
PfamiView protein in Pfam
PF07654 C1-set, 1 hit
PF00129 MHC_I, 1 hit
PRINTSiPR01638 MHCCLASSI
SMARTiView protein in SMART
SM00407 IGc1, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
SSF54452 SSF54452, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
PS00290 IG_MHC, 1 hit

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P30511-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAPRSLLLLL SGALALTDTW AGSHSLRYFS TAVSRPGRGE PRYIAVEYVD
60 70 80 90 100
DTQFLRFDSD AAIPRMEPRE PWVEQEGPQY WEWTTGYAKA NAQTDRVALR
110 120 130 140 150
NLLRRYNQSE AGSHTLQGMN GCDMGPDGRL LRGYHQHAYD GKDYISLNED
160 170 180 190 200
LRSWTAADTV AQITQRFYEA EEYAEEFRTY LEGECLELLR RYLENGKETL
210 220 230 240 250
QRADPPKAHV AHHPISDHEA TLRCWALGFY PAEITLTWQR DGEEQTQDTE
260 270 280 290 300
LVETRPAGDG TFQKWAAVVV PPGEEQRYTC HVQHEGLPQP LILRWEQSPQ
310 320 330 340
PTIPIVGIVA GLVVLGAVVT GAVVAAVMWR KKSSDRNRGS YSQAAV
Length:346
Mass (Da):39,062
Last modified:January 11, 2011 - v3
Checksum:iD4782968A67E9B7D
GO
Isoform 2 (identifier: P30511-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     204-295: Missing.

Show »
Length:254
Mass (Da):28,588
Checksum:iC81F225D409AAED2
GO
Isoform 3 (identifier: P30511-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     346-346: V → AYSVVSGNLM...MKRVQIKIFD

Show »
Length:442
Mass (Da):50,438
Checksum:i66109DEBE5EF2D57
GO

Sequence cautioni

The sequence AAC24827 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence AAH09260 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence BAB63337 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAA34947 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAB46623 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Isoform 3 (identifier: P30511-3)
Sequence conflicti353N → L in AAH09260 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05652513A → V. Corresponds to variant dbSNP:rs17875379Ensembl.1
Natural variantiVAR_05652671P → Q. Corresponds to variant dbSNP:rs17875380Ensembl.1
Natural variantiVAR_018327272P → S9 PublicationsCorresponds to variant dbSNP:rs1736924Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_038846204 – 295Missing in isoform 2. 1 PublicationAdd BLAST92
Alternative sequenceiVSP_040349346V → AYSVVSGNLMITWWSSLFLL GVLFQGYLGCLRSHSVLGRR KVGDMWILFFLWLWTSFNTA FLALQSLRFGFGFRRGRSFL LRSWHHLMKRVQIKIFD in isoform 3. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X17093 Genomic DNA Translation: CAA34947.1 Sequence problems.
AF055066 Genomic DNA Translation: AAC24827.1 Sequence problems.
AY253269 mRNA Translation: AAO86773.1
AY253270 mRNA Translation: AAO86774.1
AY253271 mRNA Translation: AAO86775.1
AF523284 Genomic DNA Translation: AAM74979.1
AF523285 Genomic DNA Translation: AAM74980.1
AF523286 Genomic DNA Translation: AAM74981.1
AF523287 Genomic DNA Translation: AAM74982.1
AF523288 Genomic DNA Translation: AAM74983.1
AF523289 Genomic DNA Translation: AAM74984.1
AF523290 Genomic DNA Translation: AAM74985.1
AF523291 Genomic DNA Translation: AAM74986.1
AF523292 Genomic DNA Translation: AAM74987.1
AF523293 Genomic DNA Translation: AAM74988.1
AF523294 Genomic DNA Translation: AAM74989.1
AF523295 Genomic DNA Translation: AAM74990.1
AF523296 Genomic DNA Translation: AAM74991.1
AF523297 Genomic DNA Translation: AAM74992.1
AY645742 Genomic DNA Translation: AAT73225.1
AY645743 Genomic DNA Translation: AAT73226.1
AY645744 Genomic DNA Translation: AAT73227.1
AY645745 Genomic DNA Translation: AAT73228.1
AY645746 Genomic DNA Translation: AAT73229.1
AY645748 Genomic DNA Translation: AAT73231.1
AY645749 Genomic DNA Translation: AAT73232.1
AY645750 Genomic DNA Translation: AAT73233.1
AY645751 Genomic DNA Translation: AAT73234.1
AY645752 Genomic DNA Translation: AAT73235.1
AY645753 Genomic DNA Translation: AAT73236.1
AY645754 Genomic DNA Translation: AAT73237.1
AY645756 Genomic DNA Translation: AAT73239.1
AY645757 Genomic DNA Translation: AAT73240.1
AY645758 Genomic DNA Translation: AAT73241.1
AY645759 Genomic DNA Translation: AAT73242.1
DQ367723 mRNA Translation: ABD38924.1
BA000025 Genomic DNA Translation: BAB63337.1 Sequence problems.
AL022723 Genomic DNA Translation: CAB46623.1 Sequence problems.
AL645939 Genomic DNA No translation available.
AL669813 Genomic DNA No translation available.
AL844851 Genomic DNA No translation available.
BX005428 Genomic DNA No translation available.
CR753818 Genomic DNA No translation available.
BX927250 Genomic DNA No translation available.
CH471081 Genomic DNA Translation: EAX03223.1
CH471081 Genomic DNA Translation: EAX03226.1
BC009260 mRNA Translation: AAH09260.2 Different initiation.
BC062991 mRNA Translation: AAH62991.1
CCDSiCCDS43437.1 [P30511-3]
CCDS43438.1 [P30511-1]
CCDS43439.1 [P30511-2]
PIRiA60384
RefSeqiNP_001091948.1, NM_001098478.1 [P30511-2]
NP_001091949.1, NM_001098479.1 [P30511-3]
NP_061823.2, NM_018950.2 [P30511-1]
UniGeneiHs.519972

Genome annotation databases

EnsembliENST00000259951; ENSP00000259951; ENSG00000204642 [P30511-3]
ENST00000334668; ENSP00000334263; ENSG00000204642 [P30511-1]
ENST00000359076; ENSP00000351977; ENSG00000206509 [P30511-2]
ENST00000376848; ENSP00000366044; ENSG00000229698 [P30511-2]
ENST00000376861; ENSP00000366057; ENSG00000204642 [P30511-1]
ENST00000383515; ENSP00000373007; ENSG00000137403 [P30511-2]
ENST00000420067; ENSP00000393535; ENSG00000235220 [P30511-2]
ENST00000434407; ENSP00000397376; ENSG00000204642 [P30511-2]
ENST00000440590; ENSP00000399835; ENSG00000237508 [P30511-2]
GeneIDi3134
KEGGihsa:3134
UCSCiuc003nnm.5 human [P30511-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiHLAF_HUMAN
AccessioniPrimary (citable) accession number: P30511
Secondary accession number(s): Q5JQI8
, Q5JQJ1, Q5SPT5, Q860R0, Q8MGQ1, Q8WLP5, Q95HC0, Q9TP68
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: January 11, 2011
Last modified: May 23, 2018
This is version 164 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

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