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Protein

HLA class I histocompatibility antigen, Cw-1 alpha chain

Gene

HLA-C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the presentation of foreign antigens to the immune system.

GO - Molecular functioni

  • peptide antigen binding Source: UniProtKB
  • TAP binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Host-virus interaction, Immunity

Enzyme and pathway databases

ReactomeiR-HSA-1236974. ER-Phagosome pathway.
R-HSA-1236977. Endosomal/Vacuolar pathway.
R-HSA-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
R-HSA-877300. Interferon gamma signaling.
R-HSA-909733. Interferon alpha/beta signaling.
R-HSA-983170. Antigen Presentation: Folding, assembly and peptide loading of class I MHC.

Names & Taxonomyi

Protein namesi
Recommended name:
HLA class I histocompatibility antigen, Cw-1 alpha chain
Alternative name(s):
MHC class I antigen Cw*1
Gene namesi
Name:HLA-C
Synonyms:HLAC
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:4933. HLA-C.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini25 – 308ExtracellularSequence analysisAdd BLAST284
Transmembranei309 – 333HelicalSequence analysisAdd BLAST25
Topological domaini334 – 366CytoplasmicSequence analysisAdd BLAST33

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, MHC I

Pathology & Biotechi

Organism-specific databases

MalaCardsiHLA-C.

Polymorphism and mutation databases

DMDMi231423.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Add BLAST24
ChainiPRO_000001886825 – 366HLA class I histocompatibility antigen, Cw-1 alpha chainAdd BLAST342

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi110N-linked (GlcNAc...)By similarity1
Disulfide bondi125 ↔ 188PROSITE-ProRule annotation
Disulfide bondi227 ↔ 283PROSITE-ProRule annotation

Post-translational modificationi

Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein. This targets the protein for rapid degradation via the ubiquitin system (By similarity).By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Ubl conjugation

Proteomic databases

EPDiP30499.
MaxQBiP30499.
PeptideAtlasiP30499.
PRIDEiP30499.

PTM databases

iPTMnetiP30499.
SwissPalmiP30499.

Expressioni

Gene expression databases

BgeeiENSG00000237022.
CleanExiHS_HLA-C.

Organism-specific databases

HPAiHPA031454.

Interactioni

Subunit structurei

Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8 MIR1 protein (By similarity).By similarity

GO - Molecular functioni

  • TAP binding Source: UniProtKB

Structurei

3D structure databases

ProteinModelPortaliP30499.
SMRiP30499.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini209 – 297Ig-like C1-typeAdd BLAST89

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni25 – 114Alpha-1Add BLAST90
Regioni115 – 206Alpha-2Add BLAST92
Regioni207 – 298Alpha-3Add BLAST92
Regioni299 – 308Connecting peptide10

Sequence similaritiesi

Belongs to the MHC class I family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG016709.
PhylomeDBiP30499.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.30.500.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
IPR001039. MHC_I_a_a1/a2.
IPR010579. MHC_I_a_C.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF00129. MHC_I. 1 hit.
PF06623. MHC_I_C. 1 hit.
[Graphical view]
PRINTSiPR01638. MHCCLASSI.
SMARTiSM00407. IGc1. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF54452. SSF54452. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P30499-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRVMEPRTLI LLLSGALALT ETWACSHSMK YFFTSVSRPG RGEPRFISVG
60 70 80 90 100
YVDDTQFVRF DSDAASPRGE PRAPWVEQEG PEYWDRETQK YNRQAQTDRV
110 120 130 140 150
SLRNLRGYYN QSEAGSHTLQ WMCGCDLGPD GRLLRGYDQY AYDGKDYIAL
160 170 180 190 200
NEDLRSWTAA DTAAQITQRK WEAAREAEER RAYLEGTCVE WLRRYLENGK
210 220 230 240 250
ESLQRAEHPK THVTHHPVSD HEATLRCWAL GFYPAEITLT WQWDGEDQTQ
260 270 280 290 300
DTELVETRPA GDGTFQKWAA VMVPSGEEQR YTCHVQHEGL PEPLTLRWEP
310 320 330 340 350
SSQPTIPIVG IVAGLAVLAV LAVLGAVVAV VMCRRKSSGG KGGSCSQAAS
360
SNSAQGSDES LIASKA
Length:366
Mass (Da):40,965
Last modified:April 1, 1993 - v1
Checksum:i285CCFCB92788744
GO

Polymorphismi

The following alleles of Cw-1 are known: Cw*01:01 (Cw1.1), Cw*01:02 (Cw1.2), Cw*01:03 and Cw*01:04. The sequence shown is that of Cw*01:01.

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0165445E → A in allele Cw*01:02, allele Cw*01:03 and allele Cw*01:04. 1
Natural variantiVAR_05645443E → K.Corresponds to variant rs1050438dbSNPEnsembl.1
Natural variantiVAR_06144448S → A.Corresponds to variant rs707911dbSNPEnsembl.1
Natural variantiVAR_06144548S → P.Corresponds to variant rs707911dbSNPEnsembl.1
Natural variantiVAR_06144648S → T.Corresponds to variant rs707911dbSNPEnsembl.1
Natural variantiVAR_05645573A → E.Corresponds to variant rs1050409dbSNPEnsembl.1
Natural variantiVAR_05645676V → M.Corresponds to variant rs1065382dbSNPEnsembl.1
Natural variantiVAR_05645790K → N.Corresponds to variant rs28626310dbSNPEnsembl.1
Natural variantiVAR_01654592N → K in allele Cw*01:02, allele Cw*01:03 and allele Cw*01:04. 1
Natural variantiVAR_016546138D → N in allele Cw*01:03. 1
Natural variantiVAR_016547140Y → F in allele Cw*01:03. 1
Natural variantiVAR_016548140Y → S in allele Cw*01:04. 1
Natural variantiVAR_016549179E → Q in allele Cw*01:02, allele Cw*01:03 and allele Cw*01:04. 1
Natural variantiVAR_016550180R → W in allele Cw*01:04. 1
Natural variantiVAR_056458201E → K.Corresponds to variant rs1131103dbSNPEnsembl.1
Natural variantiVAR_016551202S → T in allele Cw*01:02, allele Cw*01:03 and allele Cw*01:04. 1
Natural variantiVAR_016552243W → R in allele Cw*01:04. 1
Natural variantiVAR_016553272M → V in allele Cw*01:04. 1
Natural variantiVAR_016554328V → M in allele Cw*01:04. 1
Natural variantiVAR_016555364S → C in allele Cw*01:02, allele Cw*01:03 and allele Cw*01:04. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M26429 mRNA. Translation: AAA59701.1.
M16272 Genomic DNA. Translation: AAA59700.1.
M84171 mRNA. Translation: AAA59685.1.
Z46809 mRNA. Translation: CAA86839.1.
D64145 mRNA. Translation: BAA19531.1.
AJ133100 Genomic DNA. Translation: CAB38942.1.
PIRiI37528.
I54430.
I59622.
UniGeneiHs.656020.
Hs.743218.

Genome annotation databases

EnsembliENST00000438171; ENSP00000393374; ENSG00000237022.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M26429 mRNA. Translation: AAA59701.1.
M16272 Genomic DNA. Translation: AAA59700.1.
M84171 mRNA. Translation: AAA59685.1.
Z46809 mRNA. Translation: CAA86839.1.
D64145 mRNA. Translation: BAA19531.1.
AJ133100 Genomic DNA. Translation: CAB38942.1.
PIRiI37528.
I54430.
I59622.
UniGeneiHs.656020.
Hs.743218.

3D structure databases

ProteinModelPortaliP30499.
SMRiP30499.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

iPTMnetiP30499.
SwissPalmiP30499.

Polymorphism and mutation databases

DMDMi231423.

Proteomic databases

EPDiP30499.
MaxQBiP30499.
PeptideAtlasiP30499.
PRIDEiP30499.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000438171; ENSP00000393374; ENSG00000237022.

Organism-specific databases

GeneCardsiHLA-C.
HGNCiHGNC:4933. HLA-C.
HPAiHPA031454.
MalaCardsiHLA-C.
MIMi142840. gene.
neXtProtiNX_P30499.
GenAtlasiSearch...

Phylogenomic databases

HOVERGENiHBG016709.
PhylomeDBiP30499.

Enzyme and pathway databases

ReactomeiR-HSA-1236974. ER-Phagosome pathway.
R-HSA-1236977. Endosomal/Vacuolar pathway.
R-HSA-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
R-HSA-877300. Interferon gamma signaling.
R-HSA-909733. Interferon alpha/beta signaling.
R-HSA-983170. Antigen Presentation: Folding, assembly and peptide loading of class I MHC.

Miscellaneous databases

ChiTaRSiHLA-C. human.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000237022.
CleanExiHS_HLA-C.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.30.500.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
IPR001039. MHC_I_a_a1/a2.
IPR010579. MHC_I_a_C.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF00129. MHC_I. 1 hit.
PF06623. MHC_I_C. 1 hit.
[Graphical view]
PRINTSiPR01638. MHCCLASSI.
SMARTiSM00407. IGc1. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF54452. SSF54452. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry namei1C01_HUMAN
AccessioniPrimary (citable) accession number: P30499
Secondary accession number(s): O02865
, O19676, P30500, Q29986, Q9UQS9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: November 2, 2016
This is version 134 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.