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P30495

- 1B56_HUMAN

UniProt

P30495 - 1B56_HUMAN

Protein

HLA class I histocompatibility antigen, B-56 alpha chain

Gene

HLA-B

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 116 (01 Oct 2014)
      Sequence version 1 (01 Apr 1993)
      Previous versions | rss
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    Functioni

    Involved in the presentation of foreign antigens to the immune system.

    GO - Molecular functioni

    1. peptide antigen binding Source: UniProt

    GO - Biological processi

    1. antigen processing and presentation of exogenous peptide antigen via MHC class I Source: Reactome
    2. antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent Source: Reactome
    3. antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent Source: Reactome
    4. antigen processing and presentation of peptide antigen via MHC class I Source: Reactome
    5. cytokine-mediated signaling pathway Source: Reactome
    6. interferon-gamma-mediated signaling pathway Source: Reactome
    7. positive regulation of T cell mediated cytotoxicity Source: InterPro
    8. regulation of immune response Source: Reactome
    9. type I interferon signaling pathway Source: Reactome
    10. viral process Source: UniProtKB-KW

    Keywords - Biological processi

    Host-virus interaction, Immunity

    Enzyme and pathway databases

    ReactomeiREACT_111168. Endosomal/Vacuolar pathway.
    REACT_111178. ER-Phagosome pathway.
    REACT_11152. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
    REACT_25078. Interferon gamma signaling.
    REACT_25162. Interferon alpha/beta signaling.
    REACT_75795. Antigen Presentation: Folding, assembly and peptide loading of class I MHC.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    HLA class I histocompatibility antigen, B-56 alpha chain
    Alternative name(s):
    Bw-22
    Bw-56
    MHC class I antigen B*56
    Gene namesi
    Name:HLA-B
    Synonyms:HLAB
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Unplaced

    Organism-specific databases

    HGNCiHGNC:4932. HLA-B.

    Subcellular locationi

    GO - Cellular componenti

    1. cell surface Source: UniProt
    2. early endosome membrane Source: Reactome
    3. endoplasmic reticulum Source: UniProt
    4. ER to Golgi transport vesicle membrane Source: Reactome
    5. Golgi apparatus Source: UniProt
    6. Golgi membrane Source: Reactome
    7. integral component of lumenal side of endoplasmic reticulum membrane Source: Reactome
    8. MHC class I protein complex Source: UniProt
    9. phagocytic vesicle membrane Source: Reactome
    10. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Membrane, MHC I

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2424Add
    BLAST
    Chaini25 – 362338HLA class I histocompatibility antigen, B-56 alpha chainPRO_0000018859Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi110 – 1101N-linked (GlcNAc...)By similarity
    Disulfide bondi125 ↔ 188PROSITE-ProRule annotation
    Disulfide bondi227 ↔ 283PROSITE-ProRule annotation

    Post-translational modificationi

    Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein. This targets the protein for rapid degradation via the ubiquitin system By similarity.By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Ubl conjugation

    Proteomic databases

    PRIDEiP30495.

    Expressioni

    Gene expression databases

    CleanExiHS_HLA-B.
    GenevestigatoriP30495.

    Interactioni

    Subunit structurei

    Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8 MIR1 protein By similarity.By similarity

    Protein-protein interaction databases

    IntActiP30495. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliP30495.
    SMRiP30495. Positions 25-300.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini25 – 308284ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini333 – 36230CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei309 – 33224HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini209 – 29587Ig-like C1-typeAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni25 – 11490Alpha-1Add
    BLAST
    Regioni115 – 20692Alpha-2Add
    BLAST
    Regioni207 – 29892Alpha-3Add
    BLAST
    Regioni299 – 30810Connecting peptide

    Sequence similaritiesi

    Belongs to the MHC class I family.Curated

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    HOVERGENiHBG016709.
    InParanoidiP30495.

    Family and domain databases

    Gene3Di2.60.40.10. 1 hit.
    3.30.500.10. 1 hit.
    InterProiIPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003006. Ig/MHC_CS.
    IPR003597. Ig_C1-set.
    IPR011161. MHC_I-like_Ag-recog.
    IPR011162. MHC_I/II-like_Ag-recog.
    IPR027648. MHC_I_a.
    IPR001039. MHC_I_a_a1/a2.
    IPR010579. MHC_I_a_C.
    [Graphical view]
    PfamiPF07654. C1-set. 1 hit.
    PF00129. MHC_I. 1 hit.
    PF06623. MHC_I_C. 1 hit.
    [Graphical view]
    PRINTSiPR01638. MHCCLASSI.
    SMARTiSM00407. IGc1. 1 hit.
    [Graphical view]
    SUPFAMiSSF54452. SSF54452. 1 hit.
    PROSITEiPS50835. IG_LIKE. 1 hit.
    PS00290. IG_MHC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P30495-1 [UniParc]FASTAAdd to Basket

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    MRVTAPRTLL LLLWGALALT ETWAGSHSMR YFYTAMSRPG RGEPRFIAVG    50
    YVDDTQFVRF DSDAASPREE PRAPWIEQEG PEYWDRNTQI YKAQAQTDRE 100
    SLRNLRGYYN QSEAGSHTWQ TMYGCDLGPD GRLLRGHNQL AYDGKDYIAL 150
    NEDLSSWTAA DTAAQITQRK WEAARVAEQL RAYLEGLCVE WLRRYLENGK 200
    ETLQRADPPK THVTHHPISD HEATLRCWAL GFYPAEITLT WQRDGEDQTQ 250
    DTELVETRPA GDRTFQKWAA VVVPSGEEQR YTCHVQHEGL PKPLTLRWEP 300
    SSQSTIPIVG IVAGLAVLAV VVIGAVVATV MCRRKSSGGK GGSYSQAASS 350
    DSAQGSDVSL TA 362
    Length:362
    Mass (Da):40,478
    Last modified:April 1, 1993 - v1
    Checksum:iD442225B8A09D667
    GO

    Polymorphismi

    The following alleles of B-56 are known: B*56:01, B*56:02, B*56:03 (B22N), B*56:04, B*56:05 (B56V1), B*56:06 and B*56:07. The sequence shown is that of B*56:01.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti65 – 651A → T.1 Publication
    Corresponds to variant rs1050529 [ dbSNP | Ensembl ].
    VAR_056413
    Natural varianti69 – 691E → T in allele B*56:06; requires 2 nucleotide substitutions.
    VAR_016486
    Natural varianti87 – 871N → D.
    Corresponds to variant rs1050570 [ dbSNP | Ensembl ].
    VAR_056414
    Natural varianti87 – 871N → K.
    Corresponds to variant rs1065386 [ dbSNP | Ensembl ].
    VAR_059491
    Natural varianti97 – 971T → A.
    Corresponds to variant rs1050393 [ dbSNP | Ensembl ].
    VAR_056415
    Natural varianti98 – 981D → Y.
    Corresponds to variant rs1131215 [ dbSNP | Ensembl ].
    VAR_059492
    Natural varianti101 – 1011S → N in allele B*56:07.
    Corresponds to variant rs1050388 [ dbSNP | Ensembl ].
    VAR_016487
    Natural varianti104 – 1074NLRG → TALR in allele B*56:07.
    VAR_016488
    Natural varianti119 – 1191W → L in allele B*56:02, allele B*56:03 and allele B*56:04.
    VAR_016489
    Natural varianti121 – 1211T → R in allele B*56:02, allele B*56:03 and allele B*56:04.
    VAR_016490
    Natural varianti127 – 1271L → V in allele B*56:03, allele B*56:04, allele B*56:05 and allele B*56:06.
    VAR_016491
    Natural varianti138 – 1381N → D in allele B*56:03.
    VAR_016707
    Natural varianti140 – 1401L → S in allele B*56:03.
    VAR_016708
    Natural varianti140 – 1401L → Y in allele B*56:05 and allele B*56:06; requires 2 nucleotide substitutions.
    VAR_016492
    Natural varianti176 – 1761V → E in allele B*56:03, allele B*56:05 and allele B*56:06.
    VAR_016493
    Natural varianti180 – 1801L → W in allele B*56:03.
    VAR_016709
    Natural varianti195 – 1951Y → H in allele B*56:05 and allele B*56:06.
    VAR_016494

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M77775 mRNA. Translation: AAA03690.1.
    M77776 mRNA. Translation: AAA03689.1.
    D85762 mRNA. Translation: BAA12869.1.
    AH005456 Genomic DNA. Translation: AAB62223.1.
    AB030574 Genomic DNA. Translation: BAA82677.1.
    Y18542, Y18543 Genomic DNA. Translation: CAC12884.1.
    Y18544, Y18545 Genomic DNA. Translation: CAC12896.1.
    PIRiI72754.
    I72755.
    UniGeneiHs.654404.
    Hs.77961.

    Genome annotation databases

    EnsembliENST00000359635; ENSP00000352656; ENSG00000206450.

    Polymorphism databases

    DMDMi231418.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M77775 mRNA. Translation: AAA03690.1 .
    M77776 mRNA. Translation: AAA03689.1 .
    D85762 mRNA. Translation: BAA12869.1 .
    AH005456 Genomic DNA. Translation: AAB62223.1 .
    AB030574 Genomic DNA. Translation: BAA82677.1 .
    Y18542 , Y18543 Genomic DNA. Translation: CAC12884.1 .
    Y18544 , Y18545 Genomic DNA. Translation: CAC12896.1 .
    PIRi I72754.
    I72755.
    UniGenei Hs.654404.
    Hs.77961.

    3D structure databases

    ProteinModelPortali P30495.
    SMRi P30495. Positions 25-300.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P30495. 1 interaction.

    Polymorphism databases

    DMDMi 231418.

    Proteomic databases

    PRIDEi P30495.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000359635 ; ENSP00000352656 ; ENSG00000206450 .

    Organism-specific databases

    GeneCardsi GC06M031321.
    GC06Mn31311.
    HGNCi HGNC:4932. HLA-B.
    MIMi 142830. gene.
    neXtProti NX_P30495.
    GenAtlasi Search...

    Phylogenomic databases

    HOVERGENi HBG016709.
    InParanoidi P30495.

    Enzyme and pathway databases

    Reactomei REACT_111168. Endosomal/Vacuolar pathway.
    REACT_111178. ER-Phagosome pathway.
    REACT_11152. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
    REACT_25078. Interferon gamma signaling.
    REACT_25162. Interferon alpha/beta signaling.
    REACT_75795. Antigen Presentation: Folding, assembly and peptide loading of class I MHC.

    Miscellaneous databases

    ChiTaRSi HLA-B. human.
    SOURCEi Search...

    Gene expression databases

    CleanExi HS_HLA-B.
    Genevestigatori P30495.

    Family and domain databases

    Gene3Di 2.60.40.10. 1 hit.
    3.30.500.10. 1 hit.
    InterProi IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003006. Ig/MHC_CS.
    IPR003597. Ig_C1-set.
    IPR011161. MHC_I-like_Ag-recog.
    IPR011162. MHC_I/II-like_Ag-recog.
    IPR027648. MHC_I_a.
    IPR001039. MHC_I_a_a1/a2.
    IPR010579. MHC_I_a_C.
    [Graphical view ]
    Pfami PF07654. C1-set. 1 hit.
    PF00129. MHC_I. 1 hit.
    PF06623. MHC_I_C. 1 hit.
    [Graphical view ]
    PRINTSi PR01638. MHCCLASSI.
    SMARTi SM00407. IGc1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54452. SSF54452. 1 hit.
    PROSITEi PS50835. IG_LIKE. 1 hit.
    PS00290. IG_MHC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "HLA-Bw22: a family of molecules with identity to HLA-B7 in the alpha 1-helix."
      Hildebrand W.H., Madrigal J.A., Little A.-M., Parham P.
      J. Immunol. 148:1155-1162(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELES B*56:01 AND B*56:02).
    2. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE B*56:03).
      Tissue: Blood.
    3. "Novel HLA-B alleles."
      Steiner N.K., Lee K.W., Hurley C.K.
      Submitted (APR-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE OF 26-206 (ALLELE B*56:04).
    4. "HLA-B56V1(B*5605)."
      Juji T., Akesaka T., Kashiwase K.
      Submitted (JUL-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE OF 26-206 (ALLELE B*56:05).
    5. "Identification of two new HLA-B22 variants, HLA-B*5509 and B*5606."
      Voorter C.E., Hepkema B.G., Mulkers E.M.T., Lems S.P.M., van den Berg-Loonen E.M.
      Tissue Antigens 58:42-46(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 26-206 (ALLELE B*56:06).
    6. Cited for: NUCLEOTIDE SEQUENCE OF 26-206 (ALLELE B*56:07).
    7. Cited for: VARIANT [LARGE SCALE ANALYSIS] THR-65, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry namei1B56_HUMAN
    AccessioniPrimary (citable) accession number: P30495
    Secondary accession number(s): O19758
    , P30496, P79490, Q9GIM3, Q9GJ17, Q9TPR4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 1, 1993
    Last sequence update: April 1, 1993
    Last modified: October 1, 2014
    This is version 116 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3