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P30495 (1B56_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 113. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
HLA class I histocompatibility antigen, B-56 alpha chain
Alternative name(s):
Bw-22
Bw-56
MHC class I antigen B*56
Gene names
Name:HLA-B
Synonyms:HLAB
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length362 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Involved in the presentation of foreign antigens to the immune system.

Subunit structure

Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8 MIR1 protein By similarity.

Subcellular location

Membrane; Single-pass type I membrane protein.

Post-translational modification

Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein. This targets the protein for rapid degradation via the ubiquitin system By similarity.

Polymorphism

The following alleles of B-56 are known: B*56:01, B*56:02, B*56:03 (B22N), B*56:04, B*56:05 (B56V1), B*56:06 and B*56:07. The sequence shown is that of B*56:01.

Sequence similarities

Belongs to the MHC class I family.

Contains 1 Ig-like C1-type (immunoglobulin-like) domain.

Ontologies

Keywords
   Biological processHost-virus interaction
Immunity
   Cellular componentMembrane
MHC I
   Coding sequence diversityPolymorphism
   DomainSignal
Transmembrane
Transmembrane helix
   PTMDisulfide bond
Glycoprotein
Ubl conjugation
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processantigen processing and presentation of exogenous peptide antigen via MHC class I

Traceable author statement. Source: Reactome

antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent

Traceable author statement. Source: Reactome

antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent

Traceable author statement. Source: Reactome

antigen processing and presentation of peptide antigen via MHC class I

Traceable author statement. Source: Reactome

cytokine-mediated signaling pathway

Traceable author statement. Source: Reactome

interferon-gamma-mediated signaling pathway

Traceable author statement. Source: Reactome

positive regulation of T cell mediated cytotoxicity

Inferred from electronic annotation. Source: InterPro

regulation of immune response

Traceable author statement. Source: Reactome

type I interferon signaling pathway

Traceable author statement. Source: Reactome

viral process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentER to Golgi transport vesicle membrane

Traceable author statement. Source: Reactome

Golgi membrane

Traceable author statement. Source: Reactome

MHC class I protein complex

Inferred from sequence or structural similarity. Source: UniProt

cell surface

Inferred from sequence or structural similarity. Source: UniProt

early endosome membrane

Traceable author statement. Source: Reactome

integral component of lumenal side of endoplasmic reticulum membrane

Traceable author statement. Source: Reactome

phagocytic vesicle membrane

Traceable author statement. Source: Reactome

plasma membrane

Traceable author statement. Source: Reactome

   Molecular_functionpeptide antigen binding

Inferred from sequence or structural similarity. Source: UniProt

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2424
Chain25 – 362338HLA class I histocompatibility antigen, B-56 alpha chain
PRO_0000018859

Regions

Topological domain25 – 308284Extracellular Potential
Transmembrane309 – 33224Helical; Potential
Topological domain333 – 36230Cytoplasmic Potential
Domain209 – 29587Ig-like C1-type
Region25 – 11490Alpha-1
Region115 – 20692Alpha-2
Region207 – 29892Alpha-3
Region299 – 30810Connecting peptide

Amino acid modifications

Glycosylation1101N-linked (GlcNAc...) By similarity
Disulfide bond125 ↔ 188 By similarity
Disulfide bond227 ↔ 283 By similarity

Natural variations

Natural variant651A → T. Ref.7
Corresponds to variant rs1050529 [ dbSNP | Ensembl ].
VAR_056413
Natural variant691E → T in allele B*56:06; requires 2 nucleotide substitutions.
VAR_016486
Natural variant871N → D.
Corresponds to variant rs1050570 [ dbSNP | Ensembl ].
VAR_056414
Natural variant871N → K.
Corresponds to variant rs1065386 [ dbSNP | Ensembl ].
VAR_059491
Natural variant971T → A.
Corresponds to variant rs1050393 [ dbSNP | Ensembl ].
VAR_056415
Natural variant981D → Y.
Corresponds to variant rs1131215 [ dbSNP | Ensembl ].
VAR_059492
Natural variant1011S → N in allele B*56:07.
Corresponds to variant rs1050388 [ dbSNP | Ensembl ].
VAR_016487
Natural variant104 – 1074NLRG → TALR in allele B*56:07.
VAR_016488
Natural variant1191W → L in allele B*56:02, allele B*56:03 and allele B*56:04.
VAR_016489
Natural variant1211T → R in allele B*56:02, allele B*56:03 and allele B*56:04.
VAR_016490
Natural variant1271L → V in allele B*56:03, allele B*56:04, allele B*56:05 and allele B*56:06.
VAR_016491
Natural variant1381N → D in allele B*56:03.
VAR_016707
Natural variant1401L → S in allele B*56:03.
VAR_016708
Natural variant1401L → Y in allele B*56:05 and allele B*56:06; requires 2 nucleotide substitutions.
VAR_016492
Natural variant1761V → E in allele B*56:03, allele B*56:05 and allele B*56:06.
VAR_016493
Natural variant1801L → W in allele B*56:03.
VAR_016709
Natural variant1951Y → H in allele B*56:05 and allele B*56:06.
VAR_016494

Sequences

Sequence LengthMass (Da)Tools
P30495 [UniParc].

Last modified April 1, 1993. Version 1.
Checksum: D442225B8A09D667

FASTA36240,478
        10         20         30         40         50         60 
MRVTAPRTLL LLLWGALALT ETWAGSHSMR YFYTAMSRPG RGEPRFIAVG YVDDTQFVRF 

        70         80         90        100        110        120 
DSDAASPREE PRAPWIEQEG PEYWDRNTQI YKAQAQTDRE SLRNLRGYYN QSEAGSHTWQ 

       130        140        150        160        170        180 
TMYGCDLGPD GRLLRGHNQL AYDGKDYIAL NEDLSSWTAA DTAAQITQRK WEAARVAEQL 

       190        200        210        220        230        240 
RAYLEGLCVE WLRRYLENGK ETLQRADPPK THVTHHPISD HEATLRCWAL GFYPAEITLT 

       250        260        270        280        290        300 
WQRDGEDQTQ DTELVETRPA GDRTFQKWAA VVVPSGEEQR YTCHVQHEGL PKPLTLRWEP 

       310        320        330        340        350        360 
SSQSTIPIVG IVAGLAVLAV VVIGAVVATV MCRRKSSGGK GGSYSQAASS DSAQGSDVSL 


TA 

« Hide

References

« Hide 'large scale' references
[1]"HLA-Bw22: a family of molecules with identity to HLA-B7 in the alpha 1-helix."
Hildebrand W.H., Madrigal J.A., Little A.-M., Parham P.
J. Immunol. 148:1155-1162(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELES B*56:01 AND B*56:02).
[2]"Five HLA-B22 group alleles in Japanese."
Bannai M., Tokunaga K., Tanaka H., Lin L., Kashiwase K., Tokunaga K., Juji T.
Tissue Antigens 49:376-382(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE B*56:03).
Tissue: Blood.
[3]"Novel HLA-B alleles."
Steiner N.K., Lee K.W., Hurley C.K.
Submitted (APR-1997) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE OF 26-206 (ALLELE B*56:04).
[4]"HLA-B56V1(B*5605)."
Juji T., Akesaka T., Kashiwase K.
Submitted (JUL-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE OF 26-206 (ALLELE B*56:05).
[5]"Identification of two new HLA-B22 variants, HLA-B*5509 and B*5606."
Voorter C.E., Hepkema B.G., Mulkers E.M.T., Lems S.P.M., van den Berg-Loonen E.M.
Tissue Antigens 58:42-46(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 26-206 (ALLELE B*56:06).
[6]"Unexpected Bw4 and Bw6 reactivity patterns in new alleles."
Voorter C.E., van der Vlies S., Kik M., van den Berg-Loonen E.M.
Tissue Antigens 56:363-370(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE OF 26-206 (ALLELE B*56:07).
[7]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT [LARGE SCALE ANALYSIS] THR-65, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M77775 mRNA. Translation: AAA03690.1.
M77776 mRNA. Translation: AAA03689.1.
D85762 mRNA. Translation: BAA12869.1.
AH005456 Genomic DNA. Translation: AAB62223.1.
AB030574 Genomic DNA. Translation: BAA82677.1.
Y18542, Y18543 Genomic DNA. Translation: CAC12884.1.
Y18544, Y18545 Genomic DNA. Translation: CAC12896.1.
PIRI72754.
I72755.
UniGeneHs.654404.
Hs.77961.

3D structure databases

ProteinModelPortalP30495.
SMRP30495. Positions 25-300.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActP30495. 1 interaction.

Polymorphism databases

DMDM231418.

Proteomic databases

PRIDEP30495.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000359635; ENSP00000352656; ENSG00000206450.

Organism-specific databases

GeneCardsGC06M031321.
GC06Mn31311.
HGNCHGNC:4932. HLA-B.
MIM142830. gene.
neXtProtNX_P30495.
GenAtlasSearch...

Phylogenomic databases

HOVERGENHBG016709.
InParanoidP30495.

Enzyme and pathway databases

ReactomeREACT_6900. Immune System.

Gene expression databases

CleanExHS_HLA-B.
GenevestigatorP30495.

Family and domain databases

Gene3D2.60.40.10. 1 hit.
3.30.500.10. 1 hit.
InterProIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
IPR027648. MHC_I_a.
IPR001039. MHC_I_a_a1/a2.
IPR010579. MHC_I_a_C.
[Graphical view]
PfamPF07654. C1-set. 1 hit.
PF00129. MHC_I. 1 hit.
PF06623. MHC_I_C. 1 hit.
[Graphical view]
PRINTSPR01638. MHCCLASSI.
SMARTSM00407. IGc1. 1 hit.
[Graphical view]
SUPFAMSSF54452. SSF54452. 1 hit.
PROSITEPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSHLA-B. human.
SOURCESearch...

Entry information

Entry name1B56_HUMAN
AccessionPrimary (citable) accession number: P30495
Secondary accession number(s): O19758 expand/collapse secondary AC list , P30496, P79490, Q9GIM3, Q9GJ17, Q9TPR4
Entry history
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: April 16, 2014
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 6

Human chromosome 6: entries, gene names and cross-references to MIM