Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P30495

- 1B56_HUMAN

UniProt

P30495 - 1B56_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

HLA class I histocompatibility antigen, B-56 alpha chain

Gene

HLA-B

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Involved in the presentation of foreign antigens to the immune system.

GO - Molecular functioni

  1. peptide antigen binding Source: UniProt

GO - Biological processi

  1. antigen processing and presentation of exogenous peptide antigen via MHC class I Source: Reactome
  2. antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent Source: Reactome
  3. antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent Source: Reactome
  4. antigen processing and presentation of peptide antigen via MHC class I Source: Reactome
  5. cytokine-mediated signaling pathway Source: Reactome
  6. interferon-gamma-mediated signaling pathway Source: Reactome
  7. positive regulation of T cell mediated cytotoxicity Source: InterPro
  8. regulation of immune response Source: Reactome
  9. type I interferon signaling pathway Source: Reactome
  10. viral process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Host-virus interaction, Immunity

Enzyme and pathway databases

ReactomeiREACT_111168. Endosomal/Vacuolar pathway.
REACT_111178. ER-Phagosome pathway.
REACT_11152. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
REACT_25078. Interferon gamma signaling.
REACT_25162. Interferon alpha/beta signaling.
REACT_75795. Antigen Presentation: Folding, assembly and peptide loading of class I MHC.

Names & Taxonomyi

Protein namesi
Recommended name:
HLA class I histocompatibility antigen, B-56 alpha chain
Alternative name(s):
Bw-22
Bw-56
MHC class I antigen B*56
Gene namesi
Name:HLA-B
Synonyms:HLAB
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Unplaced

Organism-specific databases

HGNCiHGNC:4932. HLA-B.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini25 – 308284ExtracellularSequence AnalysisAdd
BLAST
Transmembranei309 – 33224HelicalSequence AnalysisAdd
BLAST
Topological domaini333 – 36230CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. cell surface Source: UniProt
  2. early endosome membrane Source: Reactome
  3. endoplasmic reticulum Source: UniProt
  4. ER to Golgi transport vesicle membrane Source: Reactome
  5. Golgi apparatus Source: UniProt
  6. Golgi membrane Source: Reactome
  7. integral component of lumenal side of endoplasmic reticulum membrane Source: Reactome
  8. MHC class I protein complex Source: UniProt
  9. phagocytic vesicle membrane Source: Reactome
  10. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane, MHC I

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424Add
BLAST
Chaini25 – 362338HLA class I histocompatibility antigen, B-56 alpha chainPRO_0000018859Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi110 – 1101N-linked (GlcNAc...)By similarity
Disulfide bondi125 ↔ 188PROSITE-ProRule annotation
Disulfide bondi227 ↔ 283PROSITE-ProRule annotation

Post-translational modificationi

Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein. This targets the protein for rapid degradation via the ubiquitin system (By similarity).By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Ubl conjugation

Proteomic databases

PRIDEiP30495.

Expressioni

Gene expression databases

CleanExiHS_HLA-B.
GenevestigatoriP30495.

Interactioni

Subunit structurei

Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8 MIR1 protein (By similarity).By similarity

Protein-protein interaction databases

IntActiP30495. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliP30495.
SMRiP30495. Positions 25-300.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini209 – 29587Ig-like C1-typeAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni25 – 11490Alpha-1Add
BLAST
Regioni115 – 20692Alpha-2Add
BLAST
Regioni207 – 29892Alpha-3Add
BLAST
Regioni299 – 30810Connecting peptide

Sequence similaritiesi

Belongs to the MHC class I family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG016709.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.30.500.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
IPR027648. MHC_I_a.
IPR001039. MHC_I_a_a1/a2.
IPR010579. MHC_I_a_C.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF00129. MHC_I. 1 hit.
PF06623. MHC_I_C. 1 hit.
[Graphical view]
PRINTSiPR01638. MHCCLASSI.
SMARTiSM00407. IGc1. 1 hit.
[Graphical view]
SUPFAMiSSF54452. SSF54452. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P30495-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRVTAPRTLL LLLWGALALT ETWAGSHSMR YFYTAMSRPG RGEPRFIAVG
60 70 80 90 100
YVDDTQFVRF DSDAASPREE PRAPWIEQEG PEYWDRNTQI YKAQAQTDRE
110 120 130 140 150
SLRNLRGYYN QSEAGSHTWQ TMYGCDLGPD GRLLRGHNQL AYDGKDYIAL
160 170 180 190 200
NEDLSSWTAA DTAAQITQRK WEAARVAEQL RAYLEGLCVE WLRRYLENGK
210 220 230 240 250
ETLQRADPPK THVTHHPISD HEATLRCWAL GFYPAEITLT WQRDGEDQTQ
260 270 280 290 300
DTELVETRPA GDRTFQKWAA VVVPSGEEQR YTCHVQHEGL PKPLTLRWEP
310 320 330 340 350
SSQSTIPIVG IVAGLAVLAV VVIGAVVATV MCRRKSSGGK GGSYSQAASS
360
DSAQGSDVSL TA
Length:362
Mass (Da):40,478
Last modified:April 1, 1993 - v1
Checksum:iD442225B8A09D667
GO

Polymorphismi

The following alleles of B-56 are known: B*56:01, B*56:02, B*56:03 (B22N), B*56:04, B*56:05 (B56V1), B*56:06 and B*56:07. The sequence shown is that of B*56:01.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti65 – 651A → T.1 Publication
Corresponds to variant rs1050529 [ dbSNP | Ensembl ].
VAR_056413
Natural varianti69 – 691E → T in allele B*56:06; requires 2 nucleotide substitutions.
VAR_016486
Natural varianti87 – 871N → D.
Corresponds to variant rs1050570 [ dbSNP | Ensembl ].
VAR_056414
Natural varianti87 – 871N → K.
Corresponds to variant rs1065386 [ dbSNP | Ensembl ].
VAR_059491
Natural varianti97 – 971T → A.
Corresponds to variant rs1050393 [ dbSNP | Ensembl ].
VAR_056415
Natural varianti98 – 981D → Y.
Corresponds to variant rs1131215 [ dbSNP | Ensembl ].
VAR_059492
Natural varianti101 – 1011S → N in allele B*56:07.
Corresponds to variant rs1050388 [ dbSNP | Ensembl ].
VAR_016487
Natural varianti104 – 1074NLRG → TALR in allele B*56:07.
VAR_016488
Natural varianti119 – 1191W → L in allele B*56:02, allele B*56:03 and allele B*56:04.
VAR_016489
Natural varianti121 – 1211T → R in allele B*56:02, allele B*56:03 and allele B*56:04.
VAR_016490
Natural varianti127 – 1271L → V in allele B*56:03, allele B*56:04, allele B*56:05 and allele B*56:06.
VAR_016491
Natural varianti138 – 1381N → D in allele B*56:03.
VAR_016707
Natural varianti140 – 1401L → S in allele B*56:03.
VAR_016708
Natural varianti140 – 1401L → Y in allele B*56:05 and allele B*56:06; requires 2 nucleotide substitutions.
VAR_016492
Natural varianti176 – 1761V → E in allele B*56:03, allele B*56:05 and allele B*56:06.
VAR_016493
Natural varianti180 – 1801L → W in allele B*56:03.
VAR_016709
Natural varianti195 – 1951Y → H in allele B*56:05 and allele B*56:06.
VAR_016494

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M77775 mRNA. Translation: AAA03690.1.
M77776 mRNA. Translation: AAA03689.1.
D85762 mRNA. Translation: BAA12869.1.
AH005456 Genomic DNA. Translation: AAB62223.1.
AB030574 Genomic DNA. Translation: BAA82677.1.
Y18542, Y18543 Genomic DNA. Translation: CAC12884.1.
Y18544, Y18545 Genomic DNA. Translation: CAC12896.1.
PIRiI72754.
I72755.
UniGeneiHs.654404.
Hs.77961.

Genome annotation databases

EnsembliENST00000359635; ENSP00000352656; ENSG00000206450.

Polymorphism databases

DMDMi231418.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M77775 mRNA. Translation: AAA03690.1 .
M77776 mRNA. Translation: AAA03689.1 .
D85762 mRNA. Translation: BAA12869.1 .
AH005456 Genomic DNA. Translation: AAB62223.1 .
AB030574 Genomic DNA. Translation: BAA82677.1 .
Y18542 , Y18543 Genomic DNA. Translation: CAC12884.1 .
Y18544 , Y18545 Genomic DNA. Translation: CAC12896.1 .
PIRi I72754.
I72755.
UniGenei Hs.654404.
Hs.77961.

3D structure databases

ProteinModelPortali P30495.
SMRi P30495. Positions 25-300.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P30495. 1 interaction.

Polymorphism databases

DMDMi 231418.

Proteomic databases

PRIDEi P30495.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000359635 ; ENSP00000352656 ; ENSG00000206450 .

Organism-specific databases

GeneCardsi GC06M031321.
GC06Mn31311.
HGNCi HGNC:4932. HLA-B.
MIMi 142830. gene.
neXtProti NX_P30495.
GenAtlasi Search...

Phylogenomic databases

HOVERGENi HBG016709.

Enzyme and pathway databases

Reactomei REACT_111168. Endosomal/Vacuolar pathway.
REACT_111178. ER-Phagosome pathway.
REACT_11152. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
REACT_25078. Interferon gamma signaling.
REACT_25162. Interferon alpha/beta signaling.
REACT_75795. Antigen Presentation: Folding, assembly and peptide loading of class I MHC.

Miscellaneous databases

ChiTaRSi HLA-B. human.
SOURCEi Search...

Gene expression databases

CleanExi HS_HLA-B.
Genevestigatori P30495.

Family and domain databases

Gene3Di 2.60.40.10. 1 hit.
3.30.500.10. 1 hit.
InterProi IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
IPR027648. MHC_I_a.
IPR001039. MHC_I_a_a1/a2.
IPR010579. MHC_I_a_C.
[Graphical view ]
Pfami PF07654. C1-set. 1 hit.
PF00129. MHC_I. 1 hit.
PF06623. MHC_I_C. 1 hit.
[Graphical view ]
PRINTSi PR01638. MHCCLASSI.
SMARTi SM00407. IGc1. 1 hit.
[Graphical view ]
SUPFAMi SSF54452. SSF54452. 1 hit.
PROSITEi PS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "HLA-Bw22: a family of molecules with identity to HLA-B7 in the alpha 1-helix."
    Hildebrand W.H., Madrigal J.A., Little A.-M., Parham P.
    J. Immunol. 148:1155-1162(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELES B*56:01 AND B*56:02).
  2. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE B*56:03).
    Tissue: Blood.
  3. "Novel HLA-B alleles."
    Steiner N.K., Lee K.W., Hurley C.K.
    Submitted (APR-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE OF 26-206 (ALLELE B*56:04).
  4. "HLA-B56V1(B*5605)."
    Juji T., Akesaka T., Kashiwase K.
    Submitted (JUL-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE OF 26-206 (ALLELE B*56:05).
  5. "Identification of two new HLA-B22 variants, HLA-B*5509 and B*5606."
    Voorter C.E., Hepkema B.G., Mulkers E.M.T., Lems S.P.M., van den Berg-Loonen E.M.
    Tissue Antigens 58:42-46(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 26-206 (ALLELE B*56:06).
  6. Cited for: NUCLEOTIDE SEQUENCE OF 26-206 (ALLELE B*56:07).
  7. Cited for: VARIANT [LARGE SCALE ANALYSIS] THR-65, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry namei1B56_HUMAN
AccessioniPrimary (citable) accession number: P30495
Secondary accession number(s): O19758
, P30496, P79490, Q9GIM3, Q9GJ17, Q9TPR4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: October 29, 2014
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3