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Protein

HLA class I histocompatibility antigen, B-55 alpha chain

Gene

HLA-B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the presentation of foreign antigens to the immune system.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Host-virus interaction, Immunity

Enzyme and pathway databases

ReactomeiR-HSA-1236974. ER-Phagosome pathway.
R-HSA-1236977. Endosomal/Vacuolar pathway.
R-HSA-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
R-HSA-877300. Interferon gamma signaling.
R-HSA-909733. Interferon alpha/beta signaling.
R-HSA-983170. Antigen Presentation: Folding, assembly and peptide loading of class I MHC.

Names & Taxonomyi

Protein namesi
Recommended name:
HLA class I histocompatibility antigen, B-55 alpha chain
Alternative name(s):
Bw-55
HLA class I histocompatibility antigen, B-12 alpha chain
MHC class I antigen B*55
Gene namesi
Name:HLA-B
Synonyms:HLAB
ORF Names:CDABP0067
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:4932. HLA-B.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini25 – 308284ExtracellularSequence analysisAdd
BLAST
Transmembranei309 – 33224HelicalSequence analysisAdd
BLAST
Topological domaini333 – 36230CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, MHC I

Pathology & Biotechi

Organism-specific databases

MalaCardsiHLA-B.

Polymorphism and mutation databases

DMDMi231416.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424Add
BLAST
Chaini25 – 362338HLA class I histocompatibility antigen, B-55 alpha chainPRO_0000018858Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi110 – 1101N-linked (GlcNAc...)By similarity
Disulfide bondi125 ↔ 188PROSITE-ProRule annotation
Disulfide bondi227 ↔ 283PROSITE-ProRule annotation

Post-translational modificationi

Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein. This targets the protein for rapid degradation via the ubiquitin system (By similarity).By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Ubl conjugation

Proteomic databases

EPDiP30493.
MaxQBiP30493.
PeptideAtlasiP30493.
PRIDEiP30493.

PTM databases

SwissPalmiP30493.

Expressioni

Gene expression databases

CleanExiHS_HLA-B.

Interactioni

Subunit structurei

Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8 MIR1 protein (By similarity).By similarity

Protein-protein interaction databases

IntActiP30493. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliP30493.
SMRiP30493. Positions 25-301.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini209 – 29587Ig-like C1-typeAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni25 – 11490Alpha-1Add
BLAST
Regioni115 – 20692Alpha-2Add
BLAST
Regioni207 – 29892Alpha-3Add
BLAST
Regioni299 – 30810Connecting peptide

Sequence similaritiesi

Belongs to the MHC class I family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG016709.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.30.500.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
IPR027648. MHC_I_a.
IPR001039. MHC_I_a_a1/a2.
IPR010579. MHC_I_a_C.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF00129. MHC_I. 1 hit.
PF06623. MHC_I_C. 1 hit.
[Graphical view]
PRINTSiPR01638. MHCCLASSI.
SMARTiSM00407. IGc1. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF54452. SSF54452. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P30493-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRVTAPRTLL LLLWGALALT ETWAGSHSMR YFYTAMSRPG RGEPRFIAVG
60 70 80 90 100
YVDDTQFVRF DSDAASPREE PRAPWIEQEG PEYWDRNTQI YKAQAQTDRE
110 120 130 140 150
SLRNLRGYYN QSEAGSHTWQ TMYGCDLGPD GRLLRGHNQL AYDGKDYIAL
160 170 180 190 200
NEDLSSWTAA DTAAQITQRK WEAAREAEQL RAYLEGTCVE WLRRYLENGK
210 220 230 240 250
ETLQRADPPK THVTHHPISD HEATLRCWAL GFYPAEITLT WQRDGEDQTQ
260 270 280 290 300
DTELVETRPA GDRTFQKWAA VVVPSGEEQR YTCHVQHEGL PKPLTLRWEP
310 320 330 340 350
SSQSTIPIVG IVAGLAVLAV VVIGAVVATV MCRRKSSGGK GGSYSQAASS
360
DSAQGSDVSL TA
Length:362
Mass (Da):40,496
Last modified:April 1, 1993 - v1
Checksum:i8F3C1F6D245257C4
GO

Polymorphismi

The following alleles of B-55 are known: B*55:01, B*55:02, B*55:04 (B55.2), B*55:05, B*55:08 (B*ER), B*55:09 and B*55:12. The sequence shown is that of B*55:01.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti65 – 651A → T.Combined sources
Corresponds to variant rs1050529 [ dbSNP | Ensembl ].
VAR_056410
Natural varianti82 – 821E → A in allele B*55:05.
VAR_016483
Natural varianti87 – 871N → D.
Corresponds to variant rs1050570 [ dbSNP | Ensembl ].
VAR_056411
Natural varianti87 – 871N → K.
Corresponds to variant rs1065386 [ dbSNP | Ensembl ].
VAR_059489
Natural varianti97 – 971T → A.
Corresponds to variant rs1050393 [ dbSNP | Ensembl ].
VAR_056412
Natural varianti98 – 981D → Y.
Corresponds to variant rs1131215 [ dbSNP | Ensembl ].
VAR_059490
Natural varianti101 – 1011S → N in allele B*55:12.
Corresponds to variant rs1050388 [ dbSNP | Ensembl ].
VAR_016484
Natural varianti119 – 1191W → L in allele B*55:04 and allele B*55:08; requires 2 nucleotide substitutions.
VAR_016698
Natural varianti121 – 1211T → R in allele B*55:08.
VAR_016699
Natural varianti121 – 1211T → S in allele B*55:04.
VAR_016700
Natural varianti127 – 1271L → V in allele B*55:04 and allele B*55:08.
VAR_016701
Natural varianti140 – 1401L → Y in allele B*55:04 and allele B*55:08; requires 2 nucleotide substitutions. Combined sources
VAR_016702
Natural varianti155 – 1551S → R in allele B*55:04 and allele B*55:08.
VAR_016703
Natural varianti176 – 1761E → V in allele B*55:02, allele B*55:04, allele B*55:08 and allele B*55:12.
VAR_016485
Natural varianti180 – 1801L → R in allele B*55:09.
VAR_016704
Natural varianti187 – 1871T → E in allele B*55:09; requires 2 nucleotide substitutions.
VAR_016705
Natural varianti187 – 1871T → L in allele B*55:08; requires 2 nucleotide substitutions.
VAR_016706

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M77777 mRNA. Translation: AAA03688.1.
M77778 mRNA. Translation: AAA03687.1.
AY007140 mRNA. Translation: AAG02001.1.
AJ310509 Genomic DNA. Translation: CAC34574.1.
AJ420106 Genomic DNA. Translation: CAD12250.1.
AJ420333 Genomic DNA. Translation: CAD12454.1.
D85761 mRNA. Translation: BAA12868.1.
U63653 mRNA. Translation: AAB40126.1.
AH006888 Genomic DNA. Translation: AAC61281.1.
AJ250628 Genomic DNA. Translation: CAC12872.1.
AJ250629 Genomic DNA. Translation: CAC12873.1.
PIRiI72752.
I72753.
UniGeneiHs.654404.
Hs.77961.

Genome annotation databases

EnsembliENST00000359635; ENSP00000352656; ENSG00000206450.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M77777 mRNA. Translation: AAA03688.1.
M77778 mRNA. Translation: AAA03687.1.
AY007140 mRNA. Translation: AAG02001.1.
AJ310509 Genomic DNA. Translation: CAC34574.1.
AJ420106 Genomic DNA. Translation: CAD12250.1.
AJ420333 Genomic DNA. Translation: CAD12454.1.
D85761 mRNA. Translation: BAA12868.1.
U63653 mRNA. Translation: AAB40126.1.
AH006888 Genomic DNA. Translation: AAC61281.1.
AJ250628 Genomic DNA. Translation: CAC12872.1.
AJ250629 Genomic DNA. Translation: CAC12873.1.
PIRiI72752.
I72753.
UniGeneiHs.654404.
Hs.77961.

3D structure databases

ProteinModelPortaliP30493.
SMRiP30493. Positions 25-301.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP30493. 1 interaction.

PTM databases

SwissPalmiP30493.

Polymorphism and mutation databases

DMDMi231416.

Proteomic databases

EPDiP30493.
MaxQBiP30493.
PeptideAtlasiP30493.
PRIDEiP30493.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000359635; ENSP00000352656; ENSG00000206450.

Organism-specific databases

GeneCardsiHLA-B.
HGNCiHGNC:4932. HLA-B.
MalaCardsiHLA-B.
MIMi142830. gene.
neXtProtiNX_P30493.
GenAtlasiSearch...

Phylogenomic databases

HOVERGENiHBG016709.

Enzyme and pathway databases

ReactomeiR-HSA-1236974. ER-Phagosome pathway.
R-HSA-1236977. Endosomal/Vacuolar pathway.
R-HSA-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
R-HSA-877300. Interferon gamma signaling.
R-HSA-909733. Interferon alpha/beta signaling.
R-HSA-983170. Antigen Presentation: Folding, assembly and peptide loading of class I MHC.

Miscellaneous databases

ChiTaRSiHLA-B. human.
SOURCEiSearch...

Gene expression databases

CleanExiHS_HLA-B.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.30.500.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
IPR027648. MHC_I_a.
IPR001039. MHC_I_a_a1/a2.
IPR010579. MHC_I_a_C.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF00129. MHC_I. 1 hit.
PF06623. MHC_I_C. 1 hit.
[Graphical view]
PRINTSiPR01638. MHCCLASSI.
SMARTiSM00407. IGc1. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF54452. SSF54452. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "HLA-Bw22: a family of molecules with identity to HLA-B7 in the alpha 1-helix."
    Hildebrand W.H., Madrigal J.A., Little A.-M., Parham P.
    J. Immunol. 148:1155-1162(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELES B*55:01 AND B*55:02).
  2. "Pediatric leukemia cDNA sequencing project."
    Zhou J., Yu W., Tang H., Mei G., Tsang Y.T.M., Bouck J., Gibbs R.A., Margolin J.F.
    Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ALLELE B*55:01).
    Tissue: Leukemia.
  3. Cited for: NUCLEOTIDE SEQUENCE (ALLELES B*55:01 AND B*55:12).
    Tissue: Blood.
  4. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE B*55:04).
    Tissue: Blood.
  5. "Nucleotide sequence of HLA-B*5505, which expresses a unique HLA class I polymorphism."
    Szmania S., Seurynck K., Baxter-Lowe L.A.
    Tissue Antigens 49:537-539(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE B*55:05).
  6. "Routine HLA-B genotyping with PCR-sequence-specific oligonucleotides (PCR-SSO) detects eight new alleles: B*0807, B*0809, B*1551, B*3529, B*3532, B*4025, B*5304 and B*5508."
    Kennedy C.T., Dodd R., Le T., Wallace R., Ng G., Greville W.D., Kennedy A., Taverniti A., Moses J.H., Clow N., Watson N., Dunckley H.
    Tissue Antigens 55:266-270(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 26-206 (ALLELE B*55:08).
  7. "Identification of two new HLA-B22 variants, HLA-B*5509 and B*5606."
    Voorter C.E., Hepkema B.G., Mulkers E.M.T., Lems S.P.M., van den Berg-Loonen E.M.
    Tissue Antigens 58:42-46(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 26-206 (ALLELE B*55:09).
  8. Cited for: VARIANT [LARGE SCALE ANALYSIS] THR-65, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. Cited for: VARIANT [LARGE SCALE ANALYSIS] TYR-140, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry namei1B55_HUMAN
AccessioniPrimary (citable) accession number: P30493
Secondary accession number(s): O78163
, P30494, P79489, P79523, Q8MGQ3, Q9GIZ9, Q9GJ00
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: July 6, 2016
This is version 133 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.