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Protein

HLA class I histocompatibility antigen, B-55 alpha chain

Gene

HLA-B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the presentation of foreign antigens to the immune system.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processHost-virus interaction, Immunity

Enzyme and pathway databases

ReactomeiR-HSA-1236974. ER-Phagosome pathway.
R-HSA-1236977. Endosomal/Vacuolar pathway.
R-HSA-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
R-HSA-877300. Interferon gamma signaling.
R-HSA-909733. Interferon alpha/beta signaling.
R-HSA-983170. Antigen Presentation: Folding, assembly and peptide loading of class I MHC.

Names & Taxonomyi

Protein namesi
Recommended name:
HLA class I histocompatibility antigen, B-55 alpha chain
Alternative name(s):
Bw-55
HLA class I histocompatibility antigen, B-12 alpha chain
MHC class I antigen B*55
Gene namesi
Name:HLA-B
Synonyms:HLAB
ORF Names:CDABP0067
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:4932. HLA-B.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini25 – 308ExtracellularSequence analysisAdd BLAST284
Transmembranei309 – 332HelicalSequence analysisAdd BLAST24
Topological domaini333 – 362CytoplasmicSequence analysisAdd BLAST30

Keywords - Cellular componenti

Membrane, MHC I

Pathology & Biotechi

Organism-specific databases

DisGeNETi3106.
MalaCardsiHLA-B.

Polymorphism and mutation databases

DMDMi231416.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Add BLAST24
ChainiPRO_000001885825 – 362HLA class I histocompatibility antigen, B-55 alpha chainAdd BLAST338

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi110N-linked (GlcNAc...) asparagineBy similarity1
Disulfide bondi125 ↔ 188PROSITE-ProRule annotation
Disulfide bondi227 ↔ 283PROSITE-ProRule annotation

Post-translational modificationi

Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein. This targets the protein for rapid degradation via the ubiquitin system (By similarity).By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Ubl conjugation

Proteomic databases

MaxQBiP30493.
PeptideAtlasiP30493.
PRIDEiP30493.

PTM databases

SwissPalmiP30493.

Expressioni

Gene expression databases

CleanExiHS_HLA-B.

Interactioni

Subunit structurei

Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8 MIR1 protein (By similarity).By similarity

Protein-protein interaction databases

IntActiP30493. 1 interactor.

Structurei

3D structure databases

ProteinModelPortaliP30493.
SMRiP30493.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini209 – 295Ig-like C1-typeAdd BLAST87

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni25 – 114Alpha-1Add BLAST90
Regioni115 – 206Alpha-2Add BLAST92
Regioni207 – 298Alpha-3Add BLAST92
Regioni299 – 308Connecting peptide10

Sequence similaritiesi

Belongs to the MHC class I family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG016709.
OrthoDBiEOG091G09OH.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.30.500.10. 1 hit.
InterProiView protein in InterPro
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
IPR001039. MHC_I_a_a1/a2.
IPR010579. MHC_I_a_C.
PfamiView protein in Pfam
PF07654. C1-set. 1 hit.
PF00129. MHC_I. 1 hit.
PF06623. MHC_I_C. 1 hit.
PRINTSiPR01638. MHCCLASSI.
SMARTiView protein in SMART
SM00407. IGc1. 1 hit.
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF54452. SSF54452. 1 hit.
PROSITEiView protein in PROSITE
PS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P30493-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRVTAPRTLL LLLWGALALT ETWAGSHSMR YFYTAMSRPG RGEPRFIAVG
60 70 80 90 100
YVDDTQFVRF DSDAASPREE PRAPWIEQEG PEYWDRNTQI YKAQAQTDRE
110 120 130 140 150
SLRNLRGYYN QSEAGSHTWQ TMYGCDLGPD GRLLRGHNQL AYDGKDYIAL
160 170 180 190 200
NEDLSSWTAA DTAAQITQRK WEAAREAEQL RAYLEGTCVE WLRRYLENGK
210 220 230 240 250
ETLQRADPPK THVTHHPISD HEATLRCWAL GFYPAEITLT WQRDGEDQTQ
260 270 280 290 300
DTELVETRPA GDRTFQKWAA VVVPSGEEQR YTCHVQHEGL PKPLTLRWEP
310 320 330 340 350
SSQSTIPIVG IVAGLAVLAV VVIGAVVATV MCRRKSSGGK GGSYSQAASS
360
DSAQGSDVSL TA
Length:362
Mass (Da):40,496
Last modified:April 1, 1993 - v1
Checksum:i8F3C1F6D245257C4
GO

Polymorphismi

The following alleles of B-55 are known: B*55:01, B*55:02, B*55:04 (B55.2), B*55:05, B*55:08 (B*ER), B*55:09 and B*55:12. The sequence shown is that of B*55:01.

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05641065A → TCombined sourcesCorresponds to variant dbSNP:rs1050529Ensembl.1
Natural variantiVAR_01648382E → A in allele B*55:05. 1
Natural variantiVAR_05641187N → D. Corresponds to variant dbSNP:rs1050570Ensembl.1
Natural variantiVAR_05948987N → K. Corresponds to variant dbSNP:rs1065386Ensembl.1
Natural variantiVAR_05641297T → A. Corresponds to variant dbSNP:rs1050393Ensembl.1
Natural variantiVAR_05949098D → Y. Corresponds to variant dbSNP:rs1131215Ensembl.1
Natural variantiVAR_016484101S → N in allele B*55:12. Corresponds to variant dbSNP:rs1050388Ensembl.1
Natural variantiVAR_016698119W → L in allele B*55:04 and allele B*55:08; requires 2 nucleotide substitutions. 1
Natural variantiVAR_016699121T → R in allele B*55:08. 1
Natural variantiVAR_016700121T → S in allele B*55:04. 1
Natural variantiVAR_016701127L → V in allele B*55:04 and allele B*55:08. 1
Natural variantiVAR_016702140L → Y in allele B*55:04 and allele B*55:08; requires 2 nucleotide substitutions. Combined sources1
Natural variantiVAR_016703155S → R in allele B*55:04 and allele B*55:08. 1
Natural variantiVAR_016485176E → V in allele B*55:02, allele B*55:04, allele B*55:08 and allele B*55:12. 1
Natural variantiVAR_016704180L → R in allele B*55:09. 1
Natural variantiVAR_016705187T → E in allele B*55:09; requires 2 nucleotide substitutions. 1
Natural variantiVAR_016706187T → L in allele B*55:08; requires 2 nucleotide substitutions. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M77777 mRNA. Translation: AAA03688.1.
M77778 mRNA. Translation: AAA03687.1.
AY007140 mRNA. Translation: AAG02001.1.
AJ310509 Genomic DNA. Translation: CAC34574.1.
AJ420106 Genomic DNA. Translation: CAD12250.1.
AJ420333 Genomic DNA. Translation: CAD12454.1.
D85761 mRNA. Translation: BAA12868.1.
U63653 mRNA. Translation: AAB40126.1.
AH006888 Genomic DNA. Translation: AAC61281.1.
AJ250628 Genomic DNA. Translation: CAC12872.1.
AJ250629 Genomic DNA. Translation: CAC12873.1.
PIRiI72752.
I72753.
UniGeneiHs.654404.
Hs.726974.
Hs.77961.

Genome annotation databases

EnsembliENST00000359635; ENSP00000352656; ENSG00000206450.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry namei1B55_HUMAN
AccessioniPrimary (citable) accession number: P30493
Secondary accession number(s): O78163
, P30494, P79489, P79523, Q8MGQ3, Q9GIZ9, Q9GJ00
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: August 30, 2017
This is version 140 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families