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Protein

HLA class I histocompatibility antigen, B-44 alpha chain

Gene

HLA-B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the presentation of foreign antigens to the immune system.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processHost-virus interaction, Immunity

Enzyme and pathway databases

ReactomeiR-HSA-1236974. ER-Phagosome pathway.
R-HSA-1236977. Endosomal/Vacuolar pathway.
R-HSA-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
R-HSA-877300. Interferon gamma signaling.
R-HSA-909733. Interferon alpha/beta signaling.
R-HSA-983170. Antigen Presentation: Folding, assembly and peptide loading of class I MHC.

Names & Taxonomyi

Protein namesi
Recommended name:
HLA class I histocompatibility antigen, B-44 alpha chain
Alternative name(s):
Bw-44
MHC class I antigen B*44
Gene namesi
Name:HLA-B
Synonyms:HLAB
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:4932. HLA-B.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini25 – 309ExtracellularSequence analysisAdd BLAST285
Transmembranei310 – 333HelicalSequence analysisAdd BLAST24
Topological domaini334 – 362CytoplasmicSequence analysisAdd BLAST29

Keywords - Cellular componenti

Membrane, MHC I

Pathology & Biotechi

Organism-specific databases

DisGeNETi3106.
MalaCardsiHLA-B.

Polymorphism and mutation databases

DMDMi231404.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Add BLAST24
ChainiPRO_000001884725 – 362HLA class I histocompatibility antigen, B-44 alpha chainAdd BLAST338

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi110N-linked (GlcNAc...) asparagineBy similarity1
Disulfide bondi125 ↔ 188PROSITE-ProRule annotation1 Publication
Disulfide bondi227 ↔ 283PROSITE-ProRule annotation1 Publication

Post-translational modificationi

Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein. This targets the protein for rapid degradation via the ubiquitin system (By similarity).By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Ubl conjugation

Proteomic databases

EPDiP30481.
MaxQBiP30481.
PeptideAtlasiP30481.
PRIDEiP30481.

PTM databases

iPTMnetiP30481.
SwissPalmiP30481.

Expressioni

Gene expression databases

CleanExiHS_HLA-B.

Interactioni

Subunit structurei

Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8 MIR1 protein (By similarity).By similarity

Protein-protein interaction databases

IntActiP30481. 1 interactor.
MINTiMINT-1745657.

Structurei

Secondary structure

1362
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi27 – 36Combined sources10
Beta strandi41 – 43Combined sources3
Beta strandi45 – 52Combined sources8
Beta strandi55 – 61Combined sources7
Beta strandi64 – 66Combined sources3
Helixi74 – 76Combined sources3
Helixi81 – 108Combined sources28
Beta strandi113 – 115Combined sources3
Beta strandi118 – 127Combined sources10
Beta strandi129 – 132Combined sources4
Beta strandi133 – 142Combined sources10
Beta strandi145 – 150Combined sources6
Beta strandi157 – 161Combined sources5
Helixi162 – 173Combined sources12
Helixi176 – 185Combined sources10
Helixi187 – 198Combined sources12
Helixi200 – 203Combined sources4
Beta strandi210 – 219Combined sources10
Beta strandi222 – 235Combined sources14
Beta strandi238 – 243Combined sources6
Helixi249 – 251Combined sources3
Beta strandi252 – 254Combined sources3
Beta strandi261 – 263Combined sources3
Beta strandi265 – 274Combined sources10
Helixi278 – 280Combined sources3
Beta strandi281 – 286Combined sources6
Beta strandi290 – 292Combined sources3
Beta strandi294 – 296Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1M6OX-ray1.60A25-300[»]
1N2RX-ray1.70A25-300[»]
1SYSX-ray2.40A25-300[»]
1SYVX-ray1.70A25-300[»]
3DX6X-ray1.70A25-300[»]
3DX7X-ray1.60A25-300[»]
3DX8X-ray2.10A25-300[»]
3DXAX-ray3.50A/F/K25-300[»]
3KPLX-ray1.96A25-300[»]
3KPMX-ray1.60A25-300[»]
3KPNX-ray2.00A25-300[»]
3KPOX-ray2.30A25-300[»]
3KPPX-ray1.90A25-300[»]
3KPQX-ray1.84A25-300[»]
3KPRX-ray2.60A/F25-300[»]
3KPSX-ray2.70A25-300[»]
3L3DX-ray1.80A25-300[»]
3L3GX-ray2.10A25-300[»]
3L3IX-ray1.70A25-300[»]
3L3JX-ray2.40A25-300[»]
3L3KX-ray2.60A25-300[»]
4JQXX-ray1.90A25-302[»]
ProteinModelPortaliP30481.
SMRiP30481.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP30481.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini209 – 295Ig-like C1-typeAdd BLAST87

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni25 – 114Alpha-1Add BLAST90
Regioni115 – 206Alpha-2Add BLAST92
Regioni207 – 298Alpha-3Add BLAST92
Regioni299 – 309Connecting peptideAdd BLAST11

Sequence similaritiesi

Belongs to the MHC class I family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG016709.
OrthoDBiEOG091G09OH.
PhylomeDBiP30481.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.30.500.10. 1 hit.
InterProiView protein in InterPro
IPR007110. Ig-like_dom.
IPR036179. Ig-like_dom_sf.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR037055. MHC_I-like_Ag-recog_sf.
IPR011162. MHC_I/II-like_Ag-recog.
IPR001039. MHC_I_a_a1/a2.
IPR010579. MHC_I_a_C.
PfamiView protein in Pfam
PF07654. C1-set. 1 hit.
PF00129. MHC_I. 1 hit.
PF06623. MHC_I_C. 1 hit.
PRINTSiPR01638. MHCCLASSI.
SMARTiView protein in SMART
SM00407. IGc1. 1 hit.
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF54452. SSF54452. 1 hit.
PROSITEiView protein in PROSITE
PS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P30481-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRVTAPRTLL LLLWGAVALT ETWAGSHSMR YFYTAMSRPG RGEPRFITVG
60 70 80 90 100
YVDDTLFVRF DSDATSPRKE PRAPWIEQEG PEYWDRETQI SKTNTQTYRE
110 120 130 140 150
NLRTALRYYN QSEAGSHIIQ RMYGCDVGPD GRLLRGYDQD AYDGKDYIAL
160 170 180 190 200
NEDLSSWTAA DTAAQITQRK WEAARVAEQD RAYLEGLCVE SLRRYLENGK
210 220 230 240 250
ETLQRADPPK THVTHHPISD HEVTLRCWAL GFYPAEITLT WQRDGEDQTQ
260 270 280 290 300
DTELVETRPA GDRTFQKWAA VVVPSGEEQR YTCHVQHEGL PKPLTLRWEP
310 320 330 340 350
SSQSTVPIVG IVAGLAVLAV VVIGAVVAAV MCRRKSSGGK GGSYSQAACS
360
DSAQGSDVSL TA
Length:362
Mass (Da):40,481
Last modified:April 1, 1993 - v1
Checksum:iE45C71FDEFC628AD
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti106L → A in AAA59619 (PubMed:3459708).Curated1
Sequence conflicti223V → A in AAA59619 (PubMed:3459708).Curated1
Sequence conflicti229A → S in AAA59619 (PubMed:3459708).Curated1

Polymorphismi

The following alleles of B-44 are known: B*44:02 (B-12; B44.2), B*44:04, B*44:05, B*44:07, B*44:08 (B44BO), B*44:09, B*44:12 and B*44:13. The sequence shown is that of B*44:02.

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01646165T → A in allele B*44:07 and allele B*44:08. Corresponds to variant dbSNP:rs1050529Ensembl.1
Natural variantiVAR_01646269 – 70KE → MA in allele B*44:08. 2
Natural variantiVAR_01646385D → E in allele B*44:13. Corresponds to variant dbSNP:rs151341165Ensembl.1
Natural variantiVAR_01646487E → N in allele B*44:12; requires 2 nucleotide substitutions. 1
Natural variantiVAR_016465101N → S in allele B*44:09. Corresponds to variant dbSNP:rs1050388Ensembl.1
Natural variantiVAR_016466104 – 107TALR → NLRG in allele B*44:09. 4
Natural variantiVAR_016467140D → Y in allele B*44:05. Corresponds to variant dbSNP:rs9266150Ensembl.1
Natural variantiVAR_016468180D → L in allele B*44:03, allele B*44:07 and allele B*44:13; requires 2 nucleotide substitutions. 1
Natural variantiVAR_016469180D → R in allele B*44:04; requires 2 nucleotide substitutions. Corresponds to variant dbSNP:rs376871308Ensembl.1
Natural variantiVAR_016470187L → T in allele B*44:04; requires 2 nucleotide substitutions. Corresponds to variant dbSNP:rs796093434Ensembl.1
Natural variantiVAR_056385306V → I. Corresponds to variant dbSNP:rs1131500Ensembl.1
Natural variantiVAR_056386329A → T. Corresponds to variant dbSNP:rs1051488Ensembl.1
Natural variantiVAR_061422349C → S. Corresponds to variant dbSNP:rs2308655Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M24038 Genomic DNA. Translation: AAA59663.1.
X64366 mRNA. Translation: CAA45718.1.
L42282 Genomic DNA. Translation: AAB51454.1.
L42283 Genomic DNA. Translation: AAB51455.1.
X90391 mRNA. Translation: CAA62036.1.
U64801 mRNA. Translation: AAB40632.1.
AJ133267 Genomic DNA. Translation: CAB38071.2.
AJ131118 mRNA. Translation: CAB37868.1.
AJ309936 Genomic DNA. Translation: CAC33891.1.
AJ309937 Genomic DNA. Translation: CAC33892.1.
AJ535113 mRNA. Translation: CAD59381.1.
AJ550735 Genomic DNA. Translation: CAD79566.1.
BX248310 Genomic DNA. No translation available.
M15470 mRNA. Translation: AAA59619.1.
PIRiA25295. HLHUB4.
I61861.
S25415.
UniGeneiHs.654404.
Hs.726974.
Hs.77961.

Genome annotation databases

EnsembliENST00000421349; ENSP00000405365; ENSG00000228964.
UCSCiuc011jij.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry namei1B44_HUMAN
AccessioniPrimary (citable) accession number: P30481
Secondary accession number(s): P10320
, P30482, P79524, Q29850, Q5RIP1, Q860I4, Q861B5, Q9BCM7, Q9MYC3, Q9UQS8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: October 25, 2017
This is version 157 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families