HLA class I histocompatibility antigen, B-42 alpha chain precursor

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P30480 (1B42_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 115. History...

Clusters with 100%, 90%, 50% identity |

Documents (5) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
HLA class I histocompatibility antigen, B-42 alpha chain

Alternative name(s):
MHC class I antigen B*42

Gene names

Name:	HLA-B
Synonyms:	HLAB

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	362 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Involved in the presentation of foreign antigens to the immune system.
Subunit structure	Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8 MIR1 protein By similarity.
Subcellular location	Membrane; Single-pass type I membrane protein.
Post-translational modification	Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein. This targets the protein for rapid degradation via the ubiquitin system By similarity.
Polymorphism	The following alleles of B-42 are known: B42:01 (Bw-42) and B42:02. The sequence shown is that of B*42:01.
Sequence similarities	Belongs to the MHC class I family. Contains 1 Ig-like C1-type (immunoglobulin-like) domain.

Ontologies

Keywords
Biological process	Host-virus interaction Immunity
Cellular component	MHC I Membrane
Coding sequence diversity	Polymorphism
Domain	Signal Transmembrane Transmembrane helix
PTM	Disulfide bond Glycoprotein Ubl conjugation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent Traceable author statement. Source: Reactome antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent Traceable author statement. Source: Reactome interferon-gamma-mediated signaling pathway Traceable author statement. Source: Reactome regulation of immune response Traceable author statement. Source: Reactome type I interferon-mediated signaling pathway Traceable author statement. Source: Reactome virus-host interaction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	ER to Golgi transport vesicle membrane Traceable author statement. Source: Reactome Golgi membrane Traceable author statement. Source: Reactome MHC class I protein complex Inferred from electronic annotation. Source: UniProtKB-KW early endosome membrane Traceable author statement. Source: Reactome integral to lumenal side of endoplasmic reticulum membrane Traceable author statement. Source: Reactome phagocytic vesicle membrane Traceable author statement. Source: Reactome plasma membrane Traceable author statement. Source: Reactome
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 24

Chain

25 – 362

338

HLA class I histocompatibility antigen, B-42 alpha chain

PRO_0000018846

Regions

Topological domain

25 – 309

285

Extracellular Potential

Transmembrane

310 – 333

Helical; Potential

Topological domain

334 – 362

Cytoplasmic Potential

Domain

209 – 295

Ig-like C1-type

Region

25 – 114

Alpha-1

Region

115 – 206

Alpha-2

Region

207 – 298

Alpha-3

Region

299 – 309

Connecting peptide

Amino acid modifications

Glycosylation

110

N-linked (GlcNAc...) By similarity

Disulfide bond

125 ↔ 188

By similarity

Disulfide bond

227 ↔ 283

By similarity

Natural variations

Natural variant

M → T.
Corresponds to variant rs1050458 [ dbSNP | Ensembl ].

VAR_056372

Natural variant

V → L.
Corresponds to variant rs1050462 [ dbSNP | Ensembl ].

VAR_056373

Natural variant

L → V.
Corresponds to variant rs1131165 [ dbSNP | Ensembl ].

VAR_056374

Natural variant

Y → H in allele B*42:02.

VAR_016460

Natural variant

S → A.
Corresponds to variant rs1131170 [ dbSNP | Ensembl ].

VAR_056375

Natural variant

V → M.
Corresponds to variant rs1050486 [ dbSNP | Ensembl ].

VAR_056376

Natural variant

S → A.
Corresponds to variant rs713031 [ dbSNP | Ensembl ].

VAR_061417

Natural variant

S → P.
Corresponds to variant rs713031 [ dbSNP | Ensembl ].

VAR_061418

Natural variant

S → T.
Corresponds to variant rs713031 [ dbSNP | Ensembl ].

VAR_061419

Natural variant

A → T.
Corresponds to variant rs1050529 [ dbSNP | Ensembl ].

VAR_056377

Natural variant

N → D.
Corresponds to variant rs1050570 [ dbSNP | Ensembl ].

VAR_056378

Natural variant

N → K.
Corresponds to variant rs1065386 [ dbSNP | Ensembl ].

VAR_059480

Natural variant

T → A.
Corresponds to variant rs1050393 [ dbSNP | Ensembl ].

VAR_056379

Natural variant

D → Y.
Corresponds to variant rs1131215 [ dbSNP | Ensembl ].

VAR_059481

Natural variant

101

S → N.
Corresponds to variant rs1050388 [ dbSNP | Ensembl ].

VAR_056380

Natural variant

137

H → Y.
Corresponds to variant rs1050379 [ dbSNP | Ensembl ].

VAR_056381

Natural variant

155

R → S.
Corresponds to variant rs1050654 [ dbSNP | Ensembl ].

VAR_056382

Natural variant

306

V → I.
Corresponds to variant rs1131500 [ dbSNP | Ensembl ].

VAR_056383

Natural variant

329

A → T.
Corresponds to variant rs1051488 [ dbSNP | Ensembl ].

VAR_056384

Natural variant

349

C → S.
Corresponds to variant rs2308655 [ dbSNP | Ensembl ].

VAR_061420

Natural variant

349

C → Y.
Corresponds to variant rs2308655 [ dbSNP | Ensembl ].

VAR_061421

Sequences

Sequence

Length

Mass (Da)

Tools

P30480 [UniParc].

Last modified April 1, 1993. Version 1.
Checksum: C9155AB015DEA1BE
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FASTA

362

40,333

        10         20         30         40         50         60 
MLVMAPRTVL LLLSAALALT ETWAGSHSMR YFYTSVSRPG RGEPRFISVG YVDDTQFVRF 

        70         80         90        100        110        120 
DSDAASPREE PRAPWIEQEG PEYWDRNTQI YKAQAQTDRE SLRNLRGYYN QSEAGSHTLQ 

       130        140        150        160        170        180 
SMYGCDVGPD GRLLRGHNQY AYDGKDYIAL NEDLRSWTAA DTAAQITQRK WEAARVAEQD 

       190        200        210        220        230        240 
RAYLEGTCVE WLRRYLENGK DTLERADPPK THVTHHPISD HEATLRCWAL GFYPAEITLT 

       250        260        270        280        290        300 
WQRDGEDQTQ DTELVETRPA GDRTFQKWAA VVVPSGEEQR YTCHVQHEGL PKPLTLRWEP 

       310        320        330        340        350        360 
SSQSTVPIVG IVAGLAVLAV VVIGAVVAAV MCRRKSSGGK GGSYSQAACS DSAQGSDVSL 


TA

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References

[1]	"Diversity and diversification of HLA-A,B,C alleles." Parham P., Lawlor D.A., Lomen C.E., Ennis P.D. J. Immunol. 142:3937-3950(1989) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE (ALLELE B*42:01).
[2]	*"Full-length cDNA nucleotide sequence of the HLA-B4202 allele."** Lardy N.M., Otting N., van de Weerd M.J., van de Horst A.R., Waal L.P., Bontrop R.E. Tissue Antigens 50:83-84(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE B*42:02).
[3]	"Cloning and sequencing full-length HLA-B and -C genes." Cox S.T., McWhinnie A.J., Robinson J., Marsh S.G.E., Parham P., Madrigal J.A., Little A.-M. Tissue Antigens 61:20-48(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE (ALLELE B*42:01). Tissue: Blood.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M24034 Genomic DNA. Translation: AAA59667.1. U88407 mRNA. Translation: AAC16437.1. AJ309194 Genomic DNA. Translation: CAC38393.1.
IPI	IPI00472676.
PIR	I61865.
UniGene	Hs.654404. Hs.77961.
3D structure databases
ProteinModelPortal	P30480.
ModBase	Search...
Protein-protein interaction databases
IntAct	P30480. 26 interactions.
Polymorphism databases
DMDM	231403.
Proteomic databases
PRIDE	P30480.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000412585; ENSP00000399168; ENSG00000234745.
Organism-specific databases
GeneCards	GC06M031321.
HGNC	HGNC:4932. HLA-B.
HPA	CAB015418.
MIM	142830. gene.
neXtProt	NX_P30480.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	HBG016709.
Enzyme and pathway databases
Reactome	REACT_6900. Immune System.
Gene expression databases
ArrayExpress	P30480.
Bgee	P30480.
CleanEx	HS_HLA-B.
Genevestigator	P30480.
GermOnline	ENSG00000204523. Homo sapiens.
Family and domain databases
Gene3D	2.60.40.10. 1 hit. 3.30.500.10. 1 hit.
InterPro	IPR007110. Ig-like_dom. IPR013783. Ig-like_fold. IPR003006. Ig/MHC_CS. IPR003597. Ig_C1-set. IPR011161. MHC_I-like_Ag-recog. IPR011162. MHC_I/II-like_Ag-recog. IPR001039. MHC_I_a_a1/a2. IPR010579. MHC_I_a_C. [Graphical view]
Pfam	PF07654. C1-set. 1 hit. PF00129. MHC_I. 1 hit. PF06623. MHC_I_C. 1 hit. [Graphical view]
PRINTS	PR01638. MHCCLASSI.
SMART	SM00407. IGc1. 1 hit. [Graphical view]
SUPFAM	SSF54452. MHC_I/II-like_Ag-recog. 1 hit.
PROSITE	PS50835. IG_LIKE. 1 hit. PS00290. IG_MHC. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	HLA-B. human.
SOURCE	Search...

Entry information

Entry name

1B42_HUMAN

Accession

Primary (citable) accession number: P30480
Secondary accession number(s): P79555

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 1, 1993
Last sequence update:	April 1, 1993
Last modified:	May 1, 2013
This is version 115 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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Human chromosome 6: entries, gene names and cross-references to MIM

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List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Natural variations

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Polymorphism databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents