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P30480

- 1B42_HUMAN

UniProt

P30480 - 1B42_HUMAN

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Protein

HLA class I histocompatibility antigen, B-42 alpha chain

Gene

HLA-B

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Involved in the presentation of foreign antigens to the immune system.

GO - Molecular functioni

  1. peptide antigen binding Source: UniProt

GO - Biological processi

  1. antigen processing and presentation of exogenous peptide antigen via MHC class I Source: Reactome
  2. antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent Source: Reactome
  3. antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent Source: Reactome
  4. antigen processing and presentation of peptide antigen via MHC class I Source: Reactome
  5. cytokine-mediated signaling pathway Source: Reactome
  6. interferon-gamma-mediated signaling pathway Source: Reactome
  7. positive regulation of T cell mediated cytotoxicity Source: InterPro
  8. regulation of immune response Source: Reactome
  9. type I interferon signaling pathway Source: Reactome
  10. viral process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Host-virus interaction, Immunity

Enzyme and pathway databases

ReactomeiREACT_111168. Endosomal/Vacuolar pathway.
REACT_111178. ER-Phagosome pathway.
REACT_11152. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
REACT_25078. Interferon gamma signaling.
REACT_25162. Interferon alpha/beta signaling.
REACT_75795. Antigen Presentation: Folding, assembly and peptide loading of class I MHC.

Names & Taxonomyi

Protein namesi
Recommended name:
HLA class I histocompatibility antigen, B-42 alpha chain
Alternative name(s):
MHC class I antigen B*42
Gene namesi
Name:HLA-B
Synonyms:HLAB
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 6

Organism-specific databases

HGNCiHGNC:4932. HLA-B.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini25 – 309285ExtracellularSequence AnalysisAdd
BLAST
Transmembranei310 – 33324HelicalSequence AnalysisAdd
BLAST
Topological domaini334 – 36229CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. cell surface Source: UniProt
  2. early endosome membrane Source: Reactome
  3. endoplasmic reticulum Source: UniProt
  4. ER to Golgi transport vesicle membrane Source: Reactome
  5. Golgi apparatus Source: UniProt
  6. Golgi membrane Source: Reactome
  7. integral component of lumenal side of endoplasmic reticulum membrane Source: Reactome
  8. MHC class I protein complex Source: UniProt
  9. phagocytic vesicle membrane Source: Reactome
  10. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane, MHC I

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424Add
BLAST
Chaini25 – 362338HLA class I histocompatibility antigen, B-42 alpha chainPRO_0000018846Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi110 – 1101N-linked (GlcNAc...)By similarity
Disulfide bondi125 ↔ 188PROSITE-ProRule annotation
Disulfide bondi227 ↔ 283PROSITE-ProRule annotation

Post-translational modificationi

Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein. This targets the protein for rapid degradation via the ubiquitin system (By similarity).By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Ubl conjugation

Proteomic databases

MaxQBiP30480.
PRIDEiP30480.

Expressioni

Gene expression databases

BgeeiP30480.
CleanExiHS_HLA-B.
ExpressionAtlasiP30480. baseline.
GenevestigatoriP30480.

Organism-specific databases

HPAiCAB015418.

Interactioni

Subunit structurei

Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8 MIR1 protein (By similarity).By similarity

Protein-protein interaction databases

IntActiP30480. 26 interactions.

Structurei

3D structure databases

ProteinModelPortaliP30480.
SMRiP30480. Positions 25-299.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini209 – 29587Ig-like C1-typeAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni25 – 11490Alpha-1Add
BLAST
Regioni115 – 20692Alpha-2Add
BLAST
Regioni207 – 29892Alpha-3Add
BLAST
Regioni299 – 30911Connecting peptideAdd
BLAST

Sequence similaritiesi

Belongs to the MHC class I family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG016709.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.30.500.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
IPR027648. MHC_I_a.
IPR001039. MHC_I_a_a1/a2.
IPR010579. MHC_I_a_C.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF00129. MHC_I. 1 hit.
PF06623. MHC_I_C. 1 hit.
[Graphical view]
PRINTSiPR01638. MHCCLASSI.
SMARTiSM00407. IGc1. 1 hit.
[Graphical view]
SUPFAMiSSF54452. SSF54452. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P30480-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLVMAPRTVL LLLSAALALT ETWAGSHSMR YFYTSVSRPG RGEPRFISVG
60 70 80 90 100
YVDDTQFVRF DSDAASPREE PRAPWIEQEG PEYWDRNTQI YKAQAQTDRE
110 120 130 140 150
SLRNLRGYYN QSEAGSHTLQ SMYGCDVGPD GRLLRGHNQY AYDGKDYIAL
160 170 180 190 200
NEDLRSWTAA DTAAQITQRK WEAARVAEQD RAYLEGTCVE WLRRYLENGK
210 220 230 240 250
DTLERADPPK THVTHHPISD HEATLRCWAL GFYPAEITLT WQRDGEDQTQ
260 270 280 290 300
DTELVETRPA GDRTFQKWAA VVVPSGEEQR YTCHVQHEGL PKPLTLRWEP
310 320 330 340 350
SSQSTVPIVG IVAGLAVLAV VVIGAVVAAV MCRRKSSGGK GGSYSQAACS
360
DSAQGSDVSL TA
Length:362
Mass (Da):40,333
Last modified:April 1, 1993 - v1
Checksum:iC9155AB015DEA1BE
GO

Polymorphismi

The following alleles of B-42 are known: B*42:01 (Bw-42) and B*42:02. The sequence shown is that of B*42:01.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti4 – 41M → T.
Corresponds to variant rs1050458 [ dbSNP | Ensembl ].
VAR_056372
Natural varianti9 – 91V → L.
Corresponds to variant rs1050462 [ dbSNP | Ensembl ].
VAR_056373
Natural varianti17 – 171L → V.
Corresponds to variant rs1131165 [ dbSNP | Ensembl ].
VAR_056374
Natural varianti33 – 331Y → H in allele B*42:02.
VAR_016460
Natural varianti35 – 351S → A.
Corresponds to variant rs1131170 [ dbSNP | Ensembl ].
VAR_056375
Natural varianti36 – 361V → M.
Corresponds to variant rs1050486 [ dbSNP | Ensembl ].
VAR_056376
Natural varianti48 – 481S → A.
Corresponds to variant rs713031 [ dbSNP | Ensembl ].
VAR_061417
Natural varianti48 – 481S → P.
Corresponds to variant rs713031 [ dbSNP | Ensembl ].
VAR_061418
Natural varianti48 – 481S → T.
Corresponds to variant rs713031 [ dbSNP | Ensembl ].
VAR_061419
Natural varianti65 – 651A → T.1 Publication
Corresponds to variant rs1050529 [ dbSNP | Ensembl ].
VAR_056377
Natural varianti87 – 871N → D.
Corresponds to variant rs1050570 [ dbSNP | Ensembl ].
VAR_056378
Natural varianti87 – 871N → K.
Corresponds to variant rs1065386 [ dbSNP | Ensembl ].
VAR_059480
Natural varianti97 – 971T → A.
Corresponds to variant rs1050393 [ dbSNP | Ensembl ].
VAR_056379
Natural varianti98 – 981D → Y.
Corresponds to variant rs1131215 [ dbSNP | Ensembl ].
VAR_059481
Natural varianti101 – 1011S → N.
Corresponds to variant rs1050388 [ dbSNP | Ensembl ].
VAR_056380
Natural varianti137 – 1371H → Y.
Corresponds to variant rs1050379 [ dbSNP | Ensembl ].
VAR_056381
Natural varianti155 – 1551R → S.
Corresponds to variant rs1050654 [ dbSNP | Ensembl ].
VAR_056382
Natural varianti306 – 3061V → I.
Corresponds to variant rs1131500 [ dbSNP | Ensembl ].
VAR_056383
Natural varianti329 – 3291A → T.
Corresponds to variant rs1051488 [ dbSNP | Ensembl ].
VAR_056384
Natural varianti349 – 3491C → S.
Corresponds to variant rs2308655 [ dbSNP | Ensembl ].
VAR_061420
Natural varianti349 – 3491C → Y.
Corresponds to variant rs2308655 [ dbSNP | Ensembl ].
VAR_061421

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M24034 Genomic DNA. Translation: AAA59667.1.
U88407 mRNA. Translation: AAC16437.1.
AJ309194 Genomic DNA. Translation: CAC38393.1.
PIRiI61865.
UniGeneiHs.654404.
Hs.77961.

Genome annotation databases

EnsembliENST00000412585; ENSP00000399168; ENSG00000234745.

Polymorphism databases

DMDMi231403.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M24034 Genomic DNA. Translation: AAA59667.1 .
U88407 mRNA. Translation: AAC16437.1 .
AJ309194 Genomic DNA. Translation: CAC38393.1 .
PIRi I61865.
UniGenei Hs.654404.
Hs.77961.

3D structure databases

ProteinModelPortali P30480.
SMRi P30480. Positions 25-299.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P30480. 26 interactions.

Polymorphism databases

DMDMi 231403.

Proteomic databases

MaxQBi P30480.
PRIDEi P30480.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000412585 ; ENSP00000399168 ; ENSG00000234745 .

Organism-specific databases

GeneCardsi GC06M031321.
HGNCi HGNC:4932. HLA-B.
HPAi CAB015418.
MIMi 142830. gene.
neXtProti NX_P30480.
GenAtlasi Search...

Phylogenomic databases

HOVERGENi HBG016709.

Enzyme and pathway databases

Reactomei REACT_111168. Endosomal/Vacuolar pathway.
REACT_111178. ER-Phagosome pathway.
REACT_11152. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
REACT_25078. Interferon gamma signaling.
REACT_25162. Interferon alpha/beta signaling.
REACT_75795. Antigen Presentation: Folding, assembly and peptide loading of class I MHC.

Miscellaneous databases

ChiTaRSi HLA-B. human.
SOURCEi Search...

Gene expression databases

Bgeei P30480.
CleanExi HS_HLA-B.
ExpressionAtlasi P30480. baseline.
Genevestigatori P30480.

Family and domain databases

Gene3Di 2.60.40.10. 1 hit.
3.30.500.10. 1 hit.
InterProi IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
IPR027648. MHC_I_a.
IPR001039. MHC_I_a_a1/a2.
IPR010579. MHC_I_a_C.
[Graphical view ]
Pfami PF07654. C1-set. 1 hit.
PF00129. MHC_I. 1 hit.
PF06623. MHC_I_C. 1 hit.
[Graphical view ]
PRINTSi PR01638. MHCCLASSI.
SMARTi SM00407. IGc1. 1 hit.
[Graphical view ]
SUPFAMi SSF54452. SSF54452. 1 hit.
PROSITEi PS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Diversity and diversification of HLA-A,B,C alleles."
    Parham P., Lawlor D.A., Lomen C.E., Ennis P.D.
    J. Immunol. 142:3937-3950(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE (ALLELE B*42:01).
  2. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE B*42:02).
  3. Cited for: NUCLEOTIDE SEQUENCE (ALLELE B*42:01).
    Tissue: Blood.
  4. Cited for: VARIANT [LARGE SCALE ANALYSIS] THR-65, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry namei1B42_HUMAN
AccessioniPrimary (citable) accession number: P30480
Secondary accession number(s): P79555
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: October 29, 2014
This is version 127 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3