HLA class I histocompatibility antigen, B-42 alpha chain precursor

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Reviewed, UniProtKB/Swiss-Prot P30480 (1B42_HUMAN)

Last modified January 19, 2010. Version 92. History...

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein names

Recommended name:
HLA class I histocompatibility antigen, B-42 alpha chain
Alternative name(s):
MHC class I antigen B*42

Gene names

Name:	HLA-B
Synonyms:	HLAB

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length	362 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

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General annotation (Comments)

Function	Involved in the presentation of foreign antigens to the immune system.
Subunit structure	Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8 MIR1 protein By similarity.
Subcellular location	Membrane; Single-pass type I membrane protein.
Post-translational modification	Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein. This targets the protein for rapid degradation via the ubiquitin system By similarity.
Polymorphism	The following alleles of B-42 are known: B4201 (Bw-42) and B4202. The sequence shown is that of B*4201.
Sequence similarities	Belongs to the MHC class I family. Contains 1 Ig-like C1-type (immunoglobulin-like) domain.

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Ontologies

Keywords
Biological process	Host-virus interaction Immune response
Cellular component	MHC I Membrane
Coding sequence diversity	Polymorphism
Domain	Signal Transmembrane
PTM	Disulfide bond Glycoprotein Ubl conjugation
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	antigen processing and presentation of peptide antigen via MHC class I Inferred from electronic annotation. Source: UniProtKB-KW immune response Inferred from electronic annotation. Source: UniProtKB-KW interspecies interaction between organisms Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	MHC class I protein complex Inferred from electronic annotation. Source: UniProtKB-KW integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	protein binding Inferred from physical interaction. Source: IntAct
Complete GO annotation...

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Binary interactions

With	Entry	#Exp.	IntAct
AHCY	P23526	1	EBI-1054175,EBI-1053240
EZR	P15311	1	EBI-1054175,EBI-1056902
MSN	P26038	1	EBI-1054175,EBI-528768
PAICS	P22234	1	EBI-1054175,EBI-712261
PFAS	O15067	1	EBI-1054175,EBI-1052653
PLS3	P13797	1	EBI-1054175,EBI-698052
PSMD1	Q99460	1	EBI-1054175,EBI-357874
RUVBL1	Q9Y265	1	EBI-1054175,EBI-353675
TARS	P26639	1	EBI-1054175,EBI-1042683
TKT	P29401	1	EBI-1054175,EBI-1050560
TRIM28	Q13263	1	EBI-1054175,EBI-78139
VARS	P26640	1	EBI-1054175,EBI-355765
VCP	Q5VYM0	1	EBI-1054175,EBI-1046421

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Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 24

Chain

25 – 362

338

HLA class I histocompatibility antigen, B-42 alpha chain

PRO_0000018846

Regions

Topological domain

25 – 309

285

Extracellular Potential

Transmembrane

310 – 333

Potential

Topological domain

334 – 362

Cytoplasmic Potential

Domain

209 – 295

Ig-like C1-type

Region

25 – 114

Alpha-1

Region

115 – 206

Alpha-2

Region

207 – 298

Alpha-3

Region

299 – 309

Connecting peptide

Amino acid modifications

Glycosylation

110

N-linked (GlcNAc...) By similarity

Disulfide bond

125 ↔ 188

By similarity

Disulfide bond

227 ↔ 283

By similarity

Natural variations

Natural variant

M → T: dbSNP rs1050458.

VAR_056372

Natural variant

V → L: dbSNP rs1050462.

VAR_056373

Natural variant

L → V: dbSNP rs1131165.

VAR_056374

Natural variant

Y → H in allele B*4202.

VAR_016460

Natural variant

S → A: dbSNP rs1131170.

VAR_056375

Natural variant

V → M: dbSNP rs1050486.

VAR_056376

Natural variant

S → A: dbSNP rs713031.

VAR_061417

Natural variant

S → P: dbSNP rs713031.

VAR_061418

Natural variant

S → T: dbSNP rs713031.

VAR_061419

Natural variant

A → T: dbSNP rs1050529.

VAR_056377

Natural variant

N → D: dbSNP rs1050570.

VAR_056378

Natural variant

N → K: dbSNP rs1065386.

VAR_059480

Natural variant

T → A: dbSNP rs1050393.

VAR_056379

Natural variant

D → Y: dbSNP rs1131215.

VAR_059481

Natural variant

101

S → N: dbSNP rs1050388.

VAR_056380

Natural variant

137

H → Y: dbSNP rs1050379.

VAR_056381

Natural variant

155

R → S: dbSNP rs1050654.

VAR_056382

Natural variant

306

V → I: dbSNP rs1131500.

VAR_056383

Natural variant

329

A → T: dbSNP rs1051488.

VAR_056384

Natural variant

349

C → S: dbSNP rs2308655.

VAR_061420

Natural variant

349

C → Y: dbSNP rs2308655.

VAR_061421

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Sequences

Sequence

Length

Mass (Da)

Tools

P30480-1 [UniParc].

Last modified April 1, 1993. Version 1.
Checksum: C9155AB015DEA1BE
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FASTA

362

40,333

        10         20         30         40         50         60 
MLVMAPRTVL LLLSAALALT ETWAGSHSMR YFYTSVSRPG RGEPRFISVG YVDDTQFVRF 

        70         80         90        100        110        120 
DSDAASPREE PRAPWIEQEG PEYWDRNTQI YKAQAQTDRE SLRNLRGYYN QSEAGSHTLQ 

       130        140        150        160        170        180 
SMYGCDVGPD GRLLRGHNQY AYDGKDYIAL NEDLRSWTAA DTAAQITQRK WEAARVAEQD 

       190        200        210        220        230        240 
RAYLEGTCVE WLRRYLENGK DTLERADPPK THVTHHPISD HEATLRCWAL GFYPAEITLT 

       250        260        270        280        290        300 
WQRDGEDQTQ DTELVETRPA GDRTFQKWAA VVVPSGEEQR YTCHVQHEGL PKPLTLRWEP 

       310        320        330        340        350        360 
SSQSTVPIVG IVAGLAVLAV VVIGAVVAAV MCRRKSSGGK GGSYSQAACS DSAQGSDVSL 


TA

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References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Diversity and diversification of HLA-A,B,C alleles." Parham P., Lawlor D.A., Lomen C.E., Ennis P.D. J. Immunol. 142:3937-3950(1989) [PubMed: 2715640] [Abstract] Cited for: NUCLEOTIDE SEQUENCE (ALLELE B*4201).
[2]	*"Full-length cDNA nucleotide sequence of the HLA-B4202 allele."** Lardy N.M., Otting N., van de Weerd M.J., van de Horst A.R., Waal L.P., Bontrop R.E. Tissue Antigens 50:83-84(1997) [PubMed: 9243763] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE B*4202).
[3]	"Cloning and sequencing full-length HLA-B and -C genes." Cox S.T., McWhinnie A.J., Robinson J., Marsh S.G.E., Parham P., Madrigal J.A., Little A.-M. Tissue Antigens 61:20-48(2003) [PubMed: 12622774] [Abstract] Cited for: NUCLEOTIDE SEQUENCE (ALLELE B*4201). Tissue: Blood.
[4]	Colinge J., Superti-Furga G., Bennett K.L. Submitted (OCT-2008) to UniProtKB Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY.
+	Additional computationally mapped references.

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Cross-references

Sequence databases
EMBL GenBank DDBJ	M24034 Genomic DNA. Translation: AAA59667.1. U88407 mRNA. Translation: AAC16437.1. AJ309194 Genomic DNA. Translation: CAC38393.1.
IPI	IPI00472676.
PIR	I61865.
UniGene	Hs.707171 Hs.77961
3D structure databases
SMR	P30480. Positions 25-301.
ModBase	Search...
Protein-protein interaction databases
IntAct	P30480. 288 interactions.
STRING	P30480.
Proteomic databases
PRIDE	P30480.
Genome annotation databases
Ensembl	ENST00000412585; ENSP00000399168; ENSG00000234745; Homo sapiens. [Genome view]
Organism-specific databases
GeneCards	GC06M031345.
HGNC	HGNC:4932. HLA-B.
MIM	142830. gene.
PharmGKB	PA35056.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	P30480.
Enzyme and pathway databases
Reactome	REACT_6900. Signaling in Immune system.
Gene expression databases
CleanEx	HS_HLA-B.
Genevestigator	P30480.
GermOnline	ENSG00000204523. Homo sapiens.
Family and domain databases
InterPro	IPR007110. Ig-like. IPR013783. Ig-like_fold. IPR003006. Ig/MHC_CS. IPR003597. Ig_C1-set. IPR011161. MHC_I-like_Ag-recog. IPR011162. MHC_I/II-like_Ag-recog. IPR001039. MHC_I_a_a1/a2. IPR010579. MHC_I_a_C. [Graphical view]
Gene3D	G3DSA:2.60.40.10. Ig-like_fold. 1 hit. G3DSA:3.30.500.10. MHC_I-like_Ag-recog. 1 hit.
Pfam	PF07654. C1-set. 1 hit. PF00129. MHC_I. 1 hit. PF06623. MHC_I_C. 1 hit. [Graphical view]
PRINTS	PR01638. MHCCLASSI.
SMART	SM00407. IGc1. 1 hit. [Graphical view]
PROSITE	PS50835. IG_LIKE. 1 hit. PS00290. IG_MHC. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
SOURCE	Search...

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Entry information

Entry name

1B42_HUMAN

Accession

Primary (citable) accession number: P30480
Secondary accession number(s): P79555

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 1, 1993
Last sequence update:	April 1, 1993
Last modified:	January 19, 2010
This is version 92 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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SIMILARITY comments

Index of protein domains and families

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Binary interactions

With

Entry

#Exp.

IntAct

Notes

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Natural variations

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

Other Resources

Entry information

Relevant documents