Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P30480 (1B42_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 122. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
HLA class I histocompatibility antigen, B-42 alpha chain
Alternative name(s):
MHC class I antigen B*42
Gene names
Name:HLA-B
Synonyms:HLAB
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length362 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Involved in the presentation of foreign antigens to the immune system.

Subunit structure

Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8 MIR1 protein By similarity.

Subcellular location

Membrane; Single-pass type I membrane protein.

Post-translational modification

Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein. This targets the protein for rapid degradation via the ubiquitin system By similarity.

Polymorphism

The following alleles of B-42 are known: B*42:01 (Bw-42) and B*42:02. The sequence shown is that of B*42:01.

Sequence similarities

Belongs to the MHC class I family.

Contains 1 Ig-like C1-type (immunoglobulin-like) domain.

Ontologies

Keywords
   Biological processHost-virus interaction
Immunity
   Cellular componentMembrane
MHC I
   Coding sequence diversityPolymorphism
   DomainSignal
Transmembrane
Transmembrane helix
   PTMDisulfide bond
Glycoprotein
Ubl conjugation
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processantigen processing and presentation of exogenous peptide antigen via MHC class I

Traceable author statement. Source: Reactome

antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent

Traceable author statement. Source: Reactome

antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent

Traceable author statement. Source: Reactome

antigen processing and presentation of peptide antigen via MHC class I

Traceable author statement. Source: Reactome

cytokine-mediated signaling pathway

Traceable author statement. Source: Reactome

interferon-gamma-mediated signaling pathway

Traceable author statement. Source: Reactome

positive regulation of T cell mediated cytotoxicity

Inferred from electronic annotation. Source: InterPro

regulation of immune response

Traceable author statement. Source: Reactome

type I interferon signaling pathway

Traceable author statement. Source: Reactome

viral process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentER to Golgi transport vesicle membrane

Traceable author statement. Source: Reactome

Golgi membrane

Traceable author statement. Source: Reactome

MHC class I protein complex

Inferred from sequence or structural similarity. Source: UniProt

cell surface

Inferred from sequence or structural similarity. Source: UniProt

early endosome membrane

Traceable author statement. Source: Reactome

integral component of lumenal side of endoplasmic reticulum membrane

Traceable author statement. Source: Reactome

phagocytic vesicle membrane

Traceable author statement. Source: Reactome

plasma membrane

Traceable author statement. Source: Reactome

   Molecular_functionpeptide antigen binding

Inferred from sequence or structural similarity. Source: UniProt

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2424
Chain25 – 362338HLA class I histocompatibility antigen, B-42 alpha chain
PRO_0000018846

Regions

Topological domain25 – 309285Extracellular Potential
Transmembrane310 – 33324Helical; Potential
Topological domain334 – 36229Cytoplasmic Potential
Domain209 – 29587Ig-like C1-type
Region25 – 11490Alpha-1
Region115 – 20692Alpha-2
Region207 – 29892Alpha-3
Region299 – 30911Connecting peptide

Amino acid modifications

Glycosylation1101N-linked (GlcNAc...) By similarity
Disulfide bond125 ↔ 188 By similarity
Disulfide bond227 ↔ 283 By similarity

Natural variations

Natural variant41M → T.
Corresponds to variant rs1050458 [ dbSNP | Ensembl ].
VAR_056372
Natural variant91V → L.
Corresponds to variant rs1050462 [ dbSNP | Ensembl ].
VAR_056373
Natural variant171L → V.
Corresponds to variant rs1131165 [ dbSNP | Ensembl ].
VAR_056374
Natural variant331Y → H in allele B*42:02.
VAR_016460
Natural variant351S → A.
Corresponds to variant rs1131170 [ dbSNP | Ensembl ].
VAR_056375
Natural variant361V → M.
Corresponds to variant rs1050486 [ dbSNP | Ensembl ].
VAR_056376
Natural variant481S → A.
Corresponds to variant rs713031 [ dbSNP | Ensembl ].
VAR_061417
Natural variant481S → P.
Corresponds to variant rs713031 [ dbSNP | Ensembl ].
VAR_061418
Natural variant481S → T.
Corresponds to variant rs713031 [ dbSNP | Ensembl ].
VAR_061419
Natural variant651A → T. Ref.4
Corresponds to variant rs1050529 [ dbSNP | Ensembl ].
VAR_056377
Natural variant871N → D.
Corresponds to variant rs1050570 [ dbSNP | Ensembl ].
VAR_056378
Natural variant871N → K.
Corresponds to variant rs1065386 [ dbSNP | Ensembl ].
VAR_059480
Natural variant971T → A.
Corresponds to variant rs1050393 [ dbSNP | Ensembl ].
VAR_056379
Natural variant981D → Y.
Corresponds to variant rs1131215 [ dbSNP | Ensembl ].
VAR_059481
Natural variant1011S → N.
Corresponds to variant rs1050388 [ dbSNP | Ensembl ].
VAR_056380
Natural variant1371H → Y.
Corresponds to variant rs1050379 [ dbSNP | Ensembl ].
VAR_056381
Natural variant1551R → S.
Corresponds to variant rs1050654 [ dbSNP | Ensembl ].
VAR_056382
Natural variant3061V → I.
Corresponds to variant rs1131500 [ dbSNP | Ensembl ].
VAR_056383
Natural variant3291A → T.
Corresponds to variant rs1051488 [ dbSNP | Ensembl ].
VAR_056384
Natural variant3491C → S.
Corresponds to variant rs2308655 [ dbSNP | Ensembl ].
VAR_061420
Natural variant3491C → Y.
Corresponds to variant rs2308655 [ dbSNP | Ensembl ].
VAR_061421

Sequences

Sequence LengthMass (Da)Tools
P30480 [UniParc].

Last modified April 1, 1993. Version 1.
Checksum: C9155AB015DEA1BE

FASTA36240,333
        10         20         30         40         50         60 
MLVMAPRTVL LLLSAALALT ETWAGSHSMR YFYTSVSRPG RGEPRFISVG YVDDTQFVRF 

        70         80         90        100        110        120 
DSDAASPREE PRAPWIEQEG PEYWDRNTQI YKAQAQTDRE SLRNLRGYYN QSEAGSHTLQ 

       130        140        150        160        170        180 
SMYGCDVGPD GRLLRGHNQY AYDGKDYIAL NEDLRSWTAA DTAAQITQRK WEAARVAEQD 

       190        200        210        220        230        240 
RAYLEGTCVE WLRRYLENGK DTLERADPPK THVTHHPISD HEATLRCWAL GFYPAEITLT 

       250        260        270        280        290        300 
WQRDGEDQTQ DTELVETRPA GDRTFQKWAA VVVPSGEEQR YTCHVQHEGL PKPLTLRWEP 

       310        320        330        340        350        360 
SSQSTVPIVG IVAGLAVLAV VVIGAVVAAV MCRRKSSGGK GGSYSQAACS DSAQGSDVSL 


TA 

« Hide

References

« Hide 'large scale' references
[1]"Diversity and diversification of HLA-A,B,C alleles."
Parham P., Lawlor D.A., Lomen C.E., Ennis P.D.
J. Immunol. 142:3937-3950(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE (ALLELE B*42:01).
[2]"Full-length cDNA nucleotide sequence of the HLA-B*4202 allele."
Lardy N.M., Otting N., van de Weerd M.J., van de Horst A.R., Waal L.P., Bontrop R.E.
Tissue Antigens 50:83-84(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE B*42:02).
[3]"Cloning and sequencing full-length HLA-B and -C genes."
Cox S.T., McWhinnie A.J., Robinson J., Marsh S.G.E., Parham P., Madrigal J.A., Little A.-M.
Tissue Antigens 61:20-48(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE (ALLELE B*42:01).
Tissue: Blood.
[4]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT [LARGE SCALE ANALYSIS] THR-65, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M24034 Genomic DNA. Translation: AAA59667.1.
U88407 mRNA. Translation: AAC16437.1.
AJ309194 Genomic DNA. Translation: CAC38393.1.
PIRI61865.
UniGeneHs.654404.
Hs.77961.

3D structure databases

ProteinModelPortalP30480.
SMRP30480. Positions 25-299.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActP30480. 26 interactions.

Polymorphism databases

DMDM231403.

Proteomic databases

PRIDEP30480.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000412585; ENSP00000399168; ENSG00000234745.

Organism-specific databases

GeneCardsGC06M031321.
HGNCHGNC:4932. HLA-B.
HPACAB015418.
MIM142830. gene.
neXtProtNX_P30480.
GenAtlasSearch...

Phylogenomic databases

HOVERGENHBG016709.

Enzyme and pathway databases

ReactomeREACT_6900. Immune System.

Gene expression databases

ArrayExpressP30480.
BgeeP30480.
CleanExHS_HLA-B.
GenevestigatorP30480.

Family and domain databases

Gene3D2.60.40.10. 1 hit.
3.30.500.10. 1 hit.
InterProIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
IPR027648. MHC_I_a.
IPR001039. MHC_I_a_a1/a2.
IPR010579. MHC_I_a_C.
[Graphical view]
PfamPF07654. C1-set. 1 hit.
PF00129. MHC_I. 1 hit.
PF06623. MHC_I_C. 1 hit.
[Graphical view]
PRINTSPR01638. MHCCLASSI.
SMARTSM00407. IGc1. 1 hit.
[Graphical view]
SUPFAMSSF54452. SSF54452. 1 hit.
PROSITEPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSHLA-B. human.
SOURCESearch...

Entry information

Entry name1B42_HUMAN
AccessionPrimary (citable) accession number: P30480
Secondary accession number(s): P79555
Entry history
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: April 16, 2014
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 6

Human chromosome 6: entries, gene names and cross-references to MIM