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Reviewed, UniProtKB/Swiss-Prot P30480 (1B42_HUMAN)

Last modified June 16, 2009. Version 84. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    HLA class I histocompatibility antigen, B-42 alpha chain
Alternative name(s):
    MHC class I antigen B*42
Gene names
Name: HLA-B
Synonyms: HLAB
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length362 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level.

General annotation (Comments)

Function

Involved in the presentation of foreign antigens to the immune system.

Subunit structure

Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8 MIR1 protein By similarity.

Subcellular location

Membrane; Single-pass type I membrane protein.

Post-translational modification

Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein. This targets the protein for rapid degradation via the ubiquitin system By similarity.

Polymorphism

The following alleles of B-42 are known: B*4201 (Bw-42) and B*4202. The sequence shown is that of B*4201.

Sequence similarities

Belongs to the MHC class I family.

Contains 1 Ig-like C1-type (immunoglobulin-like) domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2424
Chain25 – 362338HLA class I histocompatibility antigen, B-42 alpha chain
PRO_0000018846

Regions

Topological domain25 – 309285Extracellular Potential
Transmembrane310 – 33324 Potential
Topological domain334 – 36229Cytoplasmic Potential
Domain209 – 29587Ig-like C1-type
Region25 – 11490Alpha-1
Region115 – 20692Alpha-2
Region207 – 29892Alpha-3
Region299 – 30911Connecting peptide

Amino acid modifications

Glycosylation1101N-linked (GlcNAc...) By similarity
Disulfide bond125 ↔ 188 By similarity
Disulfide bond227 ↔ 283 By similarity

Natural variations

Natural variant41M → T: dbSNP rs1050458.
VAR_056372
Natural variant91V → L: dbSNP rs1050462.
VAR_056373
Natural variant171L → V: dbSNP rs1131165.
VAR_056374
Natural variant331Y → H in allele B*4202.
VAR_016460
Natural variant351S → A: dbSNP rs1131170.
VAR_056375
Natural variant361V → M: dbSNP rs1050486.
VAR_056376
Natural variant651A → T: dbSNP rs1050529.
VAR_056377
Natural variant871N → D: dbSNP rs1050570.
VAR_056378
Natural variant971T → A: dbSNP rs1050393.
VAR_056379
Natural variant1011S → N: dbSNP rs1050388.
VAR_056380
Natural variant1371H → Y: dbSNP rs1050379.
VAR_056381
Natural variant1551R → S: dbSNP rs1050654.
VAR_056382
Natural variant3061V → I: dbSNP rs1131500.
VAR_056383
Natural variant3291A → T: dbSNP rs1051488.
VAR_056384

Sequences

Sequence LengthMass (Da)Tools
P30480-1 [UniParc].

Last modified April 1, 1993. Version 1.
Checksum: C9155AB015DEA1BE

FASTA36240,333
        10         20         30         40         50         60 
MLVMAPRTVL LLLSAALALT ETWAGSHSMR YFYTSVSRPG RGEPRFISVG YVDDTQFVRF 

        70         80         90        100        110        120 
DSDAASPREE PRAPWIEQEG PEYWDRNTQI YKAQAQTDRE SLRNLRGYYN QSEAGSHTLQ 

       130        140        150        160        170        180 
SMYGCDVGPD GRLLRGHNQY AYDGKDYIAL NEDLRSWTAA DTAAQITQRK WEAARVAEQD 

       190        200        210        220        230        240 
RAYLEGTCVE WLRRYLENGK DTLERADPPK THVTHHPISD HEATLRCWAL GFYPAEITLT 

       250        260        270        280        290        300 
WQRDGEDQTQ DTELVETRPA GDRTFQKWAA VVVPSGEEQR YTCHVQHEGL PKPLTLRWEP 

       310        320        330        340        350        360 
SSQSTVPIVG IVAGLAVLAV VVIGAVVAAV MCRRKSSGGK GGSYSQAACS DSAQGSDVSL 


TA 

« Hide

References

« Hide 'large scale' references
[1]"Diversity and diversification of HLA-A,B,C alleles."
Parham P., Lawlor D.A., Lomen C.E., Ennis P.D.
J. Immunol. 142:3937-3950(1989) [PubMed: 2715640] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE (ALLELE B*4201).
[2]"Full-length cDNA nucleotide sequence of the HLA-B*4202 allele."
Lardy N.M., Otting N., van de Weerd M.J., van de Horst A.R., Waal L.P., Bontrop R.E.
Tissue Antigens 50:83-84(1997) [PubMed: 9243763] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE B*4202).
[3]"Cloning and sequencing full-length HLA-B and -C genes."
Cox S.T., McWhinnie A.J., Robinson J., Marsh S.G.E., Parham P., Madrigal J.A., Little A.-M.
Tissue Antigens 61:20-48(2003) [PubMed: 12622774] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE (ALLELE B*4201).
Tissue: Blood.
[4]Colinge J., Superti-Furga G., Bennett K.L.
Submitted (OCT-2008) to UniProtKB
Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY.
+Additional computationally mapped references.

Cross-references

Sequence databases

M24034 Genomic DNA. Translation: AAA59667.1.
U88407 mRNA. Translation: AAC16437.1.
AJ309194 Genomic DNA. Translation: CAC38393.1.
IPIIPI00472676.
PIRI61865.
UniGeneHs.703277
Hs.707171
Hs.77961

3D structure databases

HSSPHSSP built from PDB template 1HSA based on UniProtKB Q29961.
SMRP30480. Positions 25-300.
ModBaseSearch...

Protein-protein interaction databases

IntActP30480. 288 interactions.

Proteomic databases

PRIDEP30480.

Genome annotation databases

EnsemblENSG00000204525. Homo sapiens. [Contig view]

Organism-specific databases

GeneCardsGC06M031345.
HGNCHGNC:4932. HLA-B.
MIM142830. gene.
PharmGKBPA35056.
GenAtlasSearch...

Phylogenomic databases

HOVERGENP30480.

Enzyme and pathway databases

ReactomeREACT_6900. Signaling in Immune system.

Gene expression databases

ArrayExpressP30480.
BgeeP30480.
CleanExHS_HLA-B.
GermOnlineENSG00000204523. Homo sapiens.

Family and domain databases

InterProIPR007110. Ig-like.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR001039. MHC_I_a_a1/a2.
IPR010579. MHC_I_a_C.
[Graphical view]
Gene3DG3DSA:2.60.40.10. Ig-like_fold. 1 hit.
G3DSA:3.30.500.10. MHC_I-like_Ag-recog. 1 hit.
PfamPF07654. C1-set. 1 hit.
PF00129. MHC_I. 1 hit.
PF06623. MHC_I_C. 1 hit.
[Graphical view]
PRINTSPR01638. MHCCLASSI.
ProDomPD000050. MHC_I. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTSM00407. IGc1. 1 hit.
[Graphical view]
PROSITEPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

SOURCESearch...

Entry information

Entry name1B42_HUMAN
AccessionPrimary (citable) accession number: P30480
Secondary accession number(s): P79555
Entry history
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: June 16, 2009
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Relevant documents

Human chromosome 6

Human chromosome 6: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents