P30479 (1B41_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
HLA class I histocompatibility antigen, B-41 alpha chain

Alternative name(s):
Bw-41
MHC class I antigen B*41

Gene names

Name:	HLA-B
Synonyms:	HLAB

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	362 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Involved in the presentation of foreign antigens to the immune system.
Subunit structure	Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8 MIR1 protein By similarity.
Subcellular location	Membrane; Single-pass type I membrane protein.
Post-translational modification	Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein. This targets the protein for rapid degradation via the ubiquitin system By similarity.
Polymorphism	The following alleles of B-41 are known: B*41:01, B*41:02 (B41.2), B*41:03, B*41:04 and B*41:05. The sequence shown is that of B*41:01.
Sequence similarities	Belongs to the MHC class I family. Contains 1 Ig-like C1-type (immunoglobulin-like) domain.

Ontologies

Keywords
Biological process	Host-virus interaction Immunity
Cellular component	MHC I Membrane
Coding sequence diversity	Polymorphism
Domain	Signal Transmembrane Transmembrane helix
PTM	Disulfide bond Glycoprotein Ubl conjugation
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent Traceable author statement. Source: Reactome antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent Traceable author statement. Source: Reactome interferon-gamma-mediated signaling pathway Traceable author statement. Source: Reactome regulation of immune response Traceable author statement. Source: Reactome type I interferon-mediated signaling pathway Traceable author statement. Source: Reactome virus-host interaction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	ER to Golgi transport vesicle membrane Traceable author statement. Source: Reactome Golgi membrane Traceable author statement. Source: Reactome MHC class I protein complex Inferred from electronic annotation. Source: UniProtKB-KW early endosome membrane Traceable author statement. Source: Reactome integral to lumenal side of endoplasmic reticulum membrane Traceable author statement. Source: Reactome phagocytic vesicle membrane Traceable author statement. Source: Reactome plasma membrane Traceable author statement. Source: Reactome
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 24

24

Chain

25 – 362

338

HLA class I histocompatibility antigen, B-41 alpha chain

PRO_0000018845

Regions

Topological domain

25 – 309

285

Extracellular Potential

Transmembrane

310 – 333

24

Helical; Potential

Topological domain

334 – 362

29

Cytoplasmic Potential

Domain

209 – 295

87

Ig-like C1-type

Region

25 – 114

90

Alpha-1

Region

115 – 206

92

Alpha-2

Region

207 – 298

92

Alpha-3

Region

299 – 309

11

Connecting peptide

Amino acid modifications

Glycosylation

110

1

N-linked (GlcNAc...) By similarity

Disulfide bond

125 ↔ 188

Ref.7

Disulfide bond

227 ↔ 283

Ref.7

Natural variations

Natural variant

9

1

V → L.
Corresponds to variant rs1050462 [ dbSNP | Ensembl ].

VAR_056367

Natural variant

17

1

L → V.
Corresponds to variant rs1131165 [ dbSNP | Ensembl ].

VAR_056368

Natural variant

104

1

N → K in allele B*41:05.

VAR_016459

Natural variant

119

1

W → L in allele B*41:02, allele B*41:03 and allele B*41:04.

VAR_016455

Natural variant

121

1

R → S in allele B*41:02 and allele B*41:04.

VAR_016456

Natural variant

127

1

V → L in allele B*41:04.

VAR_016457

Natural variant

138

1

N → D in allele B*41:04.

VAR_016458

Natural variant

155

1

R → S.
Corresponds to variant rs1050654 [ dbSNP | Ensembl ].

VAR_056369

Natural variant

306

1

V → I.
Corresponds to variant rs1131500 [ dbSNP | Ensembl ].

VAR_056370

Natural variant

329

1

A → T.
Corresponds to variant rs1051488 [ dbSNP | Ensembl ].

VAR_056371

Natural variant

349

1

C → S.
Corresponds to variant rs2308655 [ dbSNP | Ensembl ].

VAR_061415

Natural variant

349

1

C → Y.
Corresponds to variant rs2308655 [ dbSNP | Ensembl ].

VAR_061416

Secondary structure

1

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362

Helix Strand Turn

Details...

Beta strand

27 – 36

10

Beta strand

45 – 52

8

Beta strand

55 – 61

7

Beta strand

64 – 66

3

Helix

74 – 76

3

Helix

81 – 108

28

Beta strand

113 – 115

3

Beta strand

118 – 127

10

Beta strand

133 – 142

10

Beta strand

145 – 150

6

Beta strand

157 – 161

5

Helix

162 – 173

12

Helix

176 – 185

10

Helix

187 – 198

12

Helix

200 – 203

4

Beta strand

210 – 235

26

Beta strand

238 – 243

6

Turn

249 – 251

3

Beta strand

261 – 263

3

Beta strand

265 – 274

10

Helix

278 – 280

3

Beta strand

281 – 286

6

Beta strand

294 – 296

3

Sequences

	Sequence		Length	Mass (Da)
	P30479 [UniParc]. Last modified April 1, 1993. Version 1. Checksum: 7443DC40CF7A38F5	FASTA	362	40,539
	10 20 30 40 50 60 MRVTAPRTVL LLLSAALALT ETWAGSHSMR YFHTAMSRPG RGEPRFITVG YVDDTLFVRF 70 80 90 100 110 120 DSDATSPRKE PRAPWIEQEG PEYWDRETQI SKTNTQTYRE SLRNLRGYYN QSEAGSHTWQ 130 140 150 160 170 180 RMYGCDVGPD GRLLRGHNQY AYDGKDYIAL NEDLRSWTAA DTAAQITQRK WEAARVAEQD 190 200 210 220 230 240 RAYLEGTCVE WLRRYLENGK DTLERADPPK THVTHHPISD HEATLRCWAL GFYPAEITLT 250 260 270 280 290 300 WQRDGEDQTQ DTELVETRPA GDRTFQKWAA VVVPSGEEQR YTCHVQHEGL PKPLTLRWEP 310 320 330 340 350 360 SSQSTVPIVG IVAGLAVLAV VVIGAVVAAV MCRRKSSGGK GGSYSQAACS DSAQGSDVSL TA

References

[1]	"Diversity and diversification of HLA-A,B,C alleles." Parham P., Lawlor D.A., Lomen C.E., Ennis P.D. J. Immunol. 142:3937-3950(1989) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE (ALLELE B*41:01).
[2]	"Confirmation of B*4101." Cox S.T. Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Tissue: Blood.
[3]	"Sequencing of a new HLA-B41 subtype (B*4102) that occurs with a high frequency in the Caucasoid population." Rufer N., Roosnek E., Kressig R., Jeannet M., Tiercy J.-M. Immunogenetics 41:333-333(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE B*41:02).
[4]	"Novel HLA-A and HLA-B alleles." Hurley C.K., Steiner N.K., Kosman C., Mitton W., Koester R., Bei M., Bush J., McCormack J., Hahn A., Henson V., Hoyer R., Wade J.A., Hartzman R.J., Ng J. Tissue Antigens 52:84-87(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 26-206 (ALLELE B*41:03).
[5]	"A novel HLA allele, B*4104, identified in a cord blood donor." Turner D.M., Vlachos G., Cavanna S.L., Brown J., Brown C., Navarrete C.V. Tissue Antigens 57:83-84(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 26-206 (ALLELE B*41:04).
[6]	"Novel HLA-B allele." Gans C.P., Hurley C.K. Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE OF 26-206 (ALLELE B*41:05).
[7]	"The impact of human leukocyte antigen (HLA) micropolymorphism on ligand specificity within the HLA-B*41 allotypic family." Bade-Doding C., Theodossis A., Gras S., Kjer-Nielsen L., Eiz-Vesper B., Seltsam A., Huyton T., Rossjohn J., McCluskey J., Blasczyk R. Haematologica 96:110-118(2011) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (1.3 ANGSTROMS) OF 25-298, DISULFIDE BONDS.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

M24035 Genomic DNA. Translation: AAA59666.1.
AJ309193 Genomic DNA. Translation: CAC38392.1.
X81363 mRNA. Translation: CAA57128.1.
AH006381 Genomic DNA. Translation: AAC33187.1.
AF258782 Genomic DNA. Translation: AAF76144.1.
AH009589 Genomic DNA. Translation: AAF81603.1.

IPI

IPI00026602.

PIR

I37492.
I61864.

UniGene

Hs.654404.
Hs.77961.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
3LN4	X-ray	1.30	A	25-298	[»]
3LN5	X-ray	1.90	A	25-298	[»]

ProteinModelPortal

P30479.

ModBase

Search...

Polymorphism databases

DMDM

231402.

Proteomic databases

PRIDE

P30479.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000425848; ENSP00000400842; ENSG00000223532.

Organism-specific databases

GeneCards

GC06M031321.

HGNC

HGNC:4932. HLA-B.

MIM

142830. gene.

neXtProt

NX_P30479.

GenAtlas

Search...

Phylogenomic databases

HOVERGEN

HBG016709.

InParanoid

P30479.

Enzyme and pathway databases

Reactome

REACT_6900. Immune System.

Gene expression databases

ArrayExpress

P30479.

CleanEx

HS_HLA-B.

Genevestigator

P30479.

Family and domain databases

Gene3D

2.60.40.10. 1 hit.
3.30.500.10. 1 hit.

InterPro

IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
IPR001039. MHC_I_a_a1/a2.
IPR010579. MHC_I_a_C.
[Graphical view]

Pfam

PF07654. C1-set. 1 hit.
PF00129. MHC_I. 1 hit.
PF06623. MHC_I_C. 1 hit.
[Graphical view]

PRINTS

PR01638. MHCCLASSI.

SMART

SM00407. IGc1. 1 hit.
[Graphical view]

SUPFAM

SSF54452. MHC_I/II-like_Ag-recog. 1 hit.

PROSITE

PS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

ChiTaRS

HLA-B. human.

EvolutionaryTrace

P30479.

SOURCE

Search...

Entry information

Entry name

1B41_HUMAN

Accession

Primary (citable) accession number: P30479
Secondary accession number(s): O19595 , Q29848, Q5TK77, Q9MY79, Q9MY94

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 1, 1993
Last sequence update:	April 1, 1993
Last modified:	May 1, 2013
This is version 113 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.