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Protein

HLA class I histocompatibility antigen, B-39 alpha chain

Gene

HLA-B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the presentation of foreign antigens to the immune system.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Host-virus interaction, Immunity

Enzyme and pathway databases

ReactomeiR-HSA-1236974. ER-Phagosome pathway.
R-HSA-1236977. Endosomal/Vacuolar pathway.
R-HSA-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
R-HSA-877300. Interferon gamma signaling.
R-HSA-909733. Interferon alpha/beta signaling.
R-HSA-983170. Antigen Presentation: Folding, assembly and peptide loading of class I MHC.

Names & Taxonomyi

Protein namesi
Recommended name:
HLA class I histocompatibility antigen, B-39 alpha chain
Alternative name(s):
MHC class I antigen B*39
Gene namesi
Name:HLA-B
Synonyms:HLAB
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:4932. HLA-B.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini25 – 308ExtracellularSequence analysisAdd BLAST284
Transmembranei309 – 332HelicalSequence analysisAdd BLAST24
Topological domaini333 – 362CytoplasmicSequence analysisAdd BLAST30

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, MHC I

Pathology & Biotechi

Organism-specific databases

MalaCardsiHLA-B.

Polymorphism and mutation databases

DMDMi231398.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Add BLAST24
ChainiPRO_000001884325 – 362HLA class I histocompatibility antigen, B-39 alpha chainAdd BLAST338

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi110N-linked (GlcNAc...)By similarity1
Disulfide bondi125 ↔ 188PROSITE-ProRule annotation
Disulfide bondi227 ↔ 283PROSITE-ProRule annotation

Post-translational modificationi

Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein. This targets the protein for rapid degradation via the ubiquitin system (By similarity).By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Ubl conjugation

Proteomic databases

MaxQBiP30475.
PaxDbiP30475.
PeptideAtlasiP30475.
PRIDEiP30475.

PTM databases

SwissPalmiP30475.

Expressioni

Gene expression databases

BgeeiENSG00000223532.
CleanExiHS_HLA-B.

Interactioni

Subunit structurei

Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8 MIR1 protein (By similarity).By similarity

Protein-protein interaction databases

STRINGi9606.ENSP00000399168.

Structurei

Secondary structure

1362
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi27 – 36Combined sources10
Beta strandi41 – 43Combined sources3
Beta strandi45 – 52Combined sources8
Beta strandi55 – 61Combined sources7
Beta strandi64 – 66Combined sources3
Helixi74 – 76Combined sources3
Helixi81 – 108Combined sources28
Beta strandi113 – 115Combined sources3
Beta strandi118 – 127Combined sources10
Beta strandi133 – 142Combined sources10
Beta strandi145 – 150Combined sources6
Beta strandi157 – 161Combined sources5
Helixi162 – 173Combined sources12
Helixi176 – 185Combined sources10
Helixi187 – 198Combined sources12
Helixi200 – 203Combined sources4
Beta strandi210 – 217Combined sources8
Beta strandi219 – 235Combined sources17
Beta strandi238 – 243Combined sources6
Helixi249 – 251Combined sources3
Beta strandi252 – 254Combined sources3
Beta strandi261 – 263Combined sources3
Beta strandi265 – 274Combined sources10
Helixi278 – 280Combined sources3
Beta strandi281 – 286Combined sources6
Beta strandi290 – 292Combined sources3
Beta strandi294 – 296Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4O2CX-ray1.80A25-298[»]
4O2EX-ray1.98A/D25-298[»]
4O2FX-ray1.90A/D25-298[»]
ProteinModelPortaliP30475.
SMRiP30475.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini209 – 295Ig-like C1-typeAdd BLAST87

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni25 – 114Alpha-1Add BLAST90
Regioni115 – 206Alpha-2Add BLAST92
Regioni207 – 298Alpha-3Add BLAST92
Regioni299 – 308Connecting peptide10

Sequence similaritiesi

Belongs to the MHC class I family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410II5V. Eukaryota.
ENOG4111K8F. LUCA.
HOVERGENiHBG016709.
OrthoDBiEOG091G09OH.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.30.500.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
IPR001039. MHC_I_a_a1/a2.
IPR010579. MHC_I_a_C.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF00129. MHC_I. 1 hit.
PF06623. MHC_I_C. 1 hit.
[Graphical view]
PRINTSiPR01638. MHCCLASSI.
SMARTiSM00407. IGc1. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF54452. SSF54452. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P30475-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLVMAPRTVL LLLSAALALT ETWAGSHSMR YFYTSVSRPG RGEPRFISVG
60 70 80 90 100
YVDDTQFVRF DSDAASPREE PRAPWIEQEG PEYWDRNTQI CKTNTQTDRE
110 120 130 140 150
SLRNLRGYYN QSEAGSHTLQ RMYGCDVGPD GRLLRGHNQF AYDGKDYIAL
160 170 180 190 200
NEDLSSWTAA DTAAQITQRK WEAARVAEQL RTYLEGTCVE WLRRYLENGK
210 220 230 240 250
ETLQRADPPK THVTHHPISD HEATLRCWAL GFYPAEITLT WQRDGEDQTQ
260 270 280 290 300
DTELVETRPA GDRTFQKWAA VVVPSGEEQR YTCHVQHEGL PKPLTLRWEP
310 320 330 340 350
SSQSTVPIVG IVAGLAVLAV VVIGAVVAAV MCRRKSSGGK GGSYSQAASS
360
DSAQGSDVSL TA
Length:362
Mass (Da):40,328
Last modified:April 1, 1993 - v1
Checksum:i422698063DEAB039
GO

Polymorphismi

The following alleles of B-39 are known: B*39:01 (B39.1), B*39:02 (B9.2), B*39:03, B*39:04 (B39N), B*39:05 (ST-16), B*39:06 (B39G), B*39:07 (B39uw3), B*39:09, B*39:10, B*39:12 (B3901v), B*39:23 (B39022v1) and B*39:24. The sequence shown is that of B*39:01.

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0563554M → T.Corresponds to variant rs1050458dbSNPEnsembl.1
Natural variantiVAR_0563569V → L.Corresponds to variant rs1050462dbSNPEnsembl.1
Natural variantiVAR_05635717L → V.Corresponds to variant rs1131165dbSNPEnsembl.1
Natural variantiVAR_01665933Y → D in allele B*39:12. 1
Natural variantiVAR_01642135S → A in allele B*39:04 and allele B*39:12. Corresponds to variant rs1131170dbSNPEnsembl.1
Natural variantiVAR_01666036V → M in allele B*39:04. Corresponds to variant rs1050486dbSNPEnsembl.1
Natural variantiVAR_06141048S → A.Corresponds to variant rs713031dbSNPEnsembl.1
Natural variantiVAR_06141148S → P.Corresponds to variant rs713031dbSNPEnsembl.1
Natural variantiVAR_06141248S → T.Corresponds to variant rs713031dbSNPEnsembl.1
Natural variantiVAR_05635865A → T.Combined sourcesCorresponds to variant rs1050529dbSNPEnsembl.1
Natural variantiVAR_05635987N → D.Corresponds to variant rs1050570dbSNPEnsembl.1
Natural variantiVAR_01642287N → E in allele B*39:02, allele B*39:08 and allele B*39:23; requires 2 nucleotide substitutions. Combined sources1
Natural variantiVAR_05947987N → K.Corresponds to variant rs1065386dbSNPEnsembl.1
Natural variantiVAR_01642391C → S in allele B*39:02, allele B*39:08 and allele B*39:23. 1
Natural variantiVAR_01642491C → Y in allele B*39:10. 1
Natural variantiVAR_05636097T → A.Corresponds to variant rs1050393dbSNPEnsembl.1
Natural variantiVAR_01642598D → Y in allele B*39:05, allele B*39:07 and allele B*39:08. Corresponds to variant rs1131215dbSNPEnsembl.1
Natural variantiVAR_016426119L → W in allele B*39:06. 1
Natural variantiVAR_016427121R → S in allele B*39:03 and allele B*39:24. 1
Natural variantiVAR_016428121R → T in allele B*39:06. 1
Natural variantiVAR_016429122M → T in allele B*39:24. 1
Natural variantiVAR_016430123Y → S in allele B*39:09. 1
Natural variantiVAR_016431138N → D in allele B*39:07. 1
Natural variantiVAR_016432140F → S in allele B*39:07. 1
Natural variantiVAR_016433168Q → R in allele B*39:23. 1
Natural variantiVAR_016434180L → R in allele B*39:08. 1
Natural variantiVAR_056361306V → I.Corresponds to variant rs1131500dbSNPEnsembl.1
Natural variantiVAR_056362329A → T.Corresponds to variant rs1051488dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M94052 Genomic DNA. Translation: AAA52658.1.
M94051 Genomic DNA. Translation: AAA52660.1.
M94053 Genomic DNA. Translation: AAA52659.1.
U04243 mRNA. Translation: AAA87396.1.
L36318 mRNA. Translation: AAA73942.1.
L22649 Genomic DNA. Translation: AAA69861.1.
U29480 mRNA. Translation: AAC50392.1.
L42024 mRNA. Translation: AAB59484.1.
U29083 mRNA. Translation: AAC32741.1.
U56246 Genomic DNA. Translation: AAB01985.1.
Y09058 mRNA. Translation: CAA70261.1.
AB091216 Genomic DNA. Translation: BAC11810.1.
AB091218 Genomic DNA. Translation: BAC11811.1.
AF428252 mRNA. Translation: AAN63555.1.
L42280 Genomic DNA. Translation: AAB51452.1.
AH004887 Genomic DNA. Translation: AAB39108.1.
AB032097 Genomic DNA. Translation: BAA84116.1.
U15640 Genomic DNA. Translation: AAA74047.1.
PIRiI38876.
I54314.
I54505.
I68850.
I84488.
UniGeneiHs.654404.
Hs.726974.
Hs.77961.

Genome annotation databases

EnsembliENST00000425848; ENSP00000400842; ENSG00000223532.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M94052 Genomic DNA. Translation: AAA52658.1.
M94051 Genomic DNA. Translation: AAA52660.1.
M94053 Genomic DNA. Translation: AAA52659.1.
U04243 mRNA. Translation: AAA87396.1.
L36318 mRNA. Translation: AAA73942.1.
L22649 Genomic DNA. Translation: AAA69861.1.
U29480 mRNA. Translation: AAC50392.1.
L42024 mRNA. Translation: AAB59484.1.
U29083 mRNA. Translation: AAC32741.1.
U56246 Genomic DNA. Translation: AAB01985.1.
Y09058 mRNA. Translation: CAA70261.1.
AB091216 Genomic DNA. Translation: BAC11810.1.
AB091218 Genomic DNA. Translation: BAC11811.1.
AF428252 mRNA. Translation: AAN63555.1.
L42280 Genomic DNA. Translation: AAB51452.1.
AH004887 Genomic DNA. Translation: AAB39108.1.
AB032097 Genomic DNA. Translation: BAA84116.1.
U15640 Genomic DNA. Translation: AAA74047.1.
PIRiI38876.
I54314.
I54505.
I68850.
I84488.
UniGeneiHs.654404.
Hs.726974.
Hs.77961.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4O2CX-ray1.80A25-298[»]
4O2EX-ray1.98A/D25-298[»]
4O2FX-ray1.90A/D25-298[»]
ProteinModelPortaliP30475.
SMRiP30475.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000399168.

PTM databases

SwissPalmiP30475.

Polymorphism and mutation databases

DMDMi231398.

Proteomic databases

MaxQBiP30475.
PaxDbiP30475.
PeptideAtlasiP30475.
PRIDEiP30475.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000425848; ENSP00000400842; ENSG00000223532.

Organism-specific databases

GeneCardsiHLA-B.
HGNCiHGNC:4932. HLA-B.
MalaCardsiHLA-B.
MIMi142830. gene.
neXtProtiNX_P30475.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410II5V. Eukaryota.
ENOG4111K8F. LUCA.
HOVERGENiHBG016709.
OrthoDBiEOG091G09OH.

Enzyme and pathway databases

ReactomeiR-HSA-1236974. ER-Phagosome pathway.
R-HSA-1236977. Endosomal/Vacuolar pathway.
R-HSA-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
R-HSA-877300. Interferon gamma signaling.
R-HSA-909733. Interferon alpha/beta signaling.
R-HSA-983170. Antigen Presentation: Folding, assembly and peptide loading of class I MHC.

Miscellaneous databases

ChiTaRSiHLA-B. human.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000223532.
CleanExiHS_HLA-B.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.30.500.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
IPR001039. MHC_I_a_a1/a2.
IPR010579. MHC_I_a_C.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF00129. MHC_I. 1 hit.
PF06623. MHC_I_C. 1 hit.
[Graphical view]
PRINTSiPR01638. MHCCLASSI.
SMARTiSM00407. IGc1. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF54452. SSF54452. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry namei1B39_HUMAN
AccessioniPrimary (citable) accession number: P30475
Secondary accession number(s): O02960
, O78217, P30476, P79504, Q29665, Q29697, Q29749, Q29847, Q29852, Q29858, Q8HWF0, Q9TPQ7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: November 2, 2016
This is version 141 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.