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Protein

HLA class I histocompatibility antigen, B-15 alpha chain

Gene

HLA-B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in the presentation of foreign antigens to the immune system.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processHost-virus interaction, Immunity

Enzyme and pathway databases

ReactomeiR-HSA-1236974 ER-Phagosome pathway
R-HSA-1236977 Endosomal/Vacuolar pathway
R-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
R-HSA-877300 Interferon gamma signaling
R-HSA-909733 Interferon alpha/beta signaling
R-HSA-983170 Antigen Presentation: Folding, assembly and peptide loading of class I MHC

Names & Taxonomyi

Protein namesi
Recommended name:
HLA class I histocompatibility antigen, B-15 alpha chain
Alternative name(s):
MHC class I antigen B*15
Gene namesi
Name:HLA-B
Synonyms:HLAB
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:4932 HLA-B
MIMi142830 gene
neXtProtiNX_P30464

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini25 – 309ExtracellularSequence analysisAdd BLAST285
Transmembranei310 – 333HelicalSequence analysisAdd BLAST24
Topological domaini334 – 362CytoplasmicSequence analysisAdd BLAST29

Keywords - Cellular componenti

Membrane, MHC I

Pathology & Biotechi

Involvement in diseasei

Stevens-Johnson syndrome (SJS)
Disease susceptibility is associated with variations affecting the gene represented in this entry. Increased susceptibility to Stevens-Johnson syndrome is conferred by allele B*15:02.
Disease descriptionA rare blistering mucocutaneous disease that share clinical and histopathologic features with toxic epidermal necrolysis. Both disorders are characterized by high fever, malaise, and a rapidly developing blistering exanthema of macules and target-like lesions accompanied by mucosal involvement. Stevens-Johnson syndrome is a milder disease characterized by destruction and detachment of the skin epithelium and mucous membranes involving less than 10% of the body surface area. Ocular symptoms include ulcerative conjunctivitis, keratitis, iritis, uveitis and sometimes blindness. It can be caused by a severe adverse reaction to particular types of medication, although Mycoplasma infections may induce some cases.
See also OMIM:608579

Organism-specific databases

DisGeNETi3106
MalaCardsiHLA-B
MIMi608579 phenotype
Orphaneti240841 Abacavir toxicity
240845 Allopurinol toxicity
825 Ankylosing spondylitis
117 Behcet disease
240871 Flucloxacilline toxicity
414750 Phenytoin or carbamazepine toxicity
275798 Pulmonary arterial hypertension associated with connective tissue disease
36426 Stevens-Johnson syndrome
3287 Takayasu arteritis

Polymorphism and mutation databases

DMDMi34305703

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Add BLAST24
ChainiPRO_000001883725 – 362HLA class I histocompatibility antigen, B-15 alpha chainAdd BLAST338

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi110N-linked (GlcNAc...) asparagineBy similarity1
Disulfide bondi125 ↔ 188PROSITE-ProRule annotation1 Publication
Disulfide bondi227 ↔ 283PROSITE-ProRule annotation1 Publication

Post-translational modificationi

Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein. This targets the protein for rapid degradation via the ubiquitin system (By similarity).By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Ubl conjugation

Proteomic databases

MaxQBiP30464
PeptideAtlasiP30464
PRIDEiP30464

PTM databases

SwissPalmiP30464

Expressioni

Gene expression databases

CleanExiHS_HLA-B

Interactioni

Subunit structurei

Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8 MIR1 protein (By similarity).By similarity

Protein-protein interaction databases

IntActiP30464 3 interactors.

Structurei

Secondary structure

1362
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi27 – 36Combined sources10
Beta strandi41 – 43Combined sources3
Beta strandi45 – 52Combined sources8
Beta strandi55 – 61Combined sources7
Beta strandi64 – 66Combined sources3
Helixi74 – 76Combined sources3
Helixi81 – 108Combined sources28
Beta strandi118 – 127Combined sources10
Beta strandi133 – 142Combined sources10
Beta strandi145 – 150Combined sources6
Beta strandi157 – 161Combined sources5
Helixi162 – 173Combined sources12
Helixi176 – 185Combined sources10
Helixi187 – 198Combined sources12
Helixi200 – 203Combined sources4
Beta strandi210 – 217Combined sources8
Beta strandi219 – 235Combined sources17
Beta strandi238 – 243Combined sources6
Helixi249 – 251Combined sources3
Beta strandi261 – 263Combined sources3
Beta strandi265 – 274Combined sources10
Helixi278 – 280Combined sources3
Beta strandi281 – 286Combined sources6
Beta strandi290 – 292Combined sources3
Beta strandi294 – 296Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1XR8X-ray2.30A25-300[»]
1XR9X-ray1.79A25-300[»]
3C9NX-ray1.87A25-300[»]
5TXSX-ray1.70A25-304[»]
ProteinModelPortaliP30464
SMRiP30464
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP30464

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini209 – 295Ig-like C1-typeAdd BLAST87

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni25 – 114Alpha-1Add BLAST90
Regioni115 – 206Alpha-2Add BLAST92
Regioni207 – 298Alpha-3Add BLAST92
Regioni299 – 309Connecting peptideAdd BLAST11

Sequence similaritiesi

Belongs to the MHC class I family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG016709
OrthoDBiEOG091G09OH
PhylomeDBiP30464

Family and domain databases

Gene3Di2.60.40.101 hit
3.30.500.101 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003006 Ig/MHC_CS
IPR003597 Ig_C1-set
IPR011161 MHC_I-like_Ag-recog
IPR037055 MHC_I-like_Ag-recog_sf
IPR011162 MHC_I/II-like_Ag-recog
IPR001039 MHC_I_a_a1/a2
IPR010579 MHC_I_a_C
PfamiView protein in Pfam
PF07654 C1-set, 1 hit
PF00129 MHC_I, 1 hit
PF06623 MHC_I_C, 1 hit
PRINTSiPR01638 MHCCLASSI
SMARTiView protein in SMART
SM00407 IGc1, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
SSF54452 SSF54452, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
PS00290 IG_MHC, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P30464-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRVTAPRTVL LLLSGALALT ETWAGSHSMR YFYTAMSRPG RGEPRFIAVG
60 70 80 90 100
YVDDTQFVRF DSDAASPRMA PRAPWIEQEG PEYWDRETQI SKTNTQTYRE
110 120 130 140 150
SLRNLRGYYN QSEAGSHTLQ RMYGCDVGPD GRLLRGHDQS AYDGKDYIAL
160 170 180 190 200
NEDLSSWTAA DTAAQITQRK WEAAREAEQW RAYLEGLCVE WLRRYLENGK
210 220 230 240 250
ETLQRADPPK THVTHHPISD HEATLRCWAL GFYPAEITLT WQRDGEDQTQ
260 270 280 290 300
DTELVETRPA GDRTFQKWAA VVVPSGEEQR YTCHVQHEGL PKPLTLRWEP
310 320 330 340 350
SSQSTIPIVG IVAGLAVLAV VVIGAVVATV MCRRKSSGGK GGSYSQAASS
360
DSAQGSDVSL TA
Length:362
Mass (Da):40,388
Last modified:August 22, 2003 - v2
Checksum:i86E938087372EBE0
GO

Polymorphismi

The following alleles of B-15 are known: B*15:01 (Bw-62; B-62), B*15:02 (Bw-75, B-75), B*15:03 (Bw-72; B-72; B-70) B*15:04, B*15:11, B*15:19 and B*15:66. The sequence shown is that of B*15:01.

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01636548A → S in allele B*15:03. Corresponds to variant dbSNP:rs713031Ensembl.1
Natural variantiVAR_01636669 – 70MA → EE in allele B*15:03. 2
Natural variantiVAR_01636787E → N in allele B*15:02 and allele B*15:11; requires 2 nucleotide substitutions. 1
Natural variantiVAR_01636891S → C in allele B*15:66. Corresponds to variant dbSNP:rs1071816Ensembl.1
Natural variantiVAR_01636991S → Y in allele B*15:11. Corresponds to variant dbSNP:rs1071816Ensembl.1
Natural variantiVAR_016370118 – 119TL → II in allele B*15:02. Corresponds to variant dbSNP:rs796332753Ensembl.2
Natural variantiVAR_016371119L → W in allele B*15:04. 1
Natural variantiVAR_016372121R → T in allele B*15:04. Corresponds to variant dbSNP:rs1071652Ensembl.1
Natural variantiVAR_016373137H → Y in allele B*15:02. Corresponds to variant dbSNP:rs1050379Ensembl.1
Natural variantiVAR_016374180W → L in allele B*15:02 and allele B*15:03. Corresponds to variant dbSNP:rs697742Ensembl.1
Natural variantiVAR_016375190 – 191EW → DG in allele B*15:19. 2
Natural variantiVAR_016376274P → L in allele B*15:19. Corresponds to variant dbSNP:rs41545517Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M75138 mRNA Translation: AAA59630.1
U03859 mRNA Translation: AAA03601.1
U03027 mRNA Translation: AAA18902.1
L11604 mRNA Translation: AAA56836.1
D50292 mRNA Translation: BAA08823.1
D50293 mRNA Translation: BAA08824.1
D50294 mRNA Translation: BAA08825.1
X61709 mRNA Translation: CAA43878.1
M84382 mRNA Translation: AAA59632.1
U70528 mRNA Translation: AAB16918.1
AJ295140 Genomic DNA Translation: CAC17462.1
AJ308399 Genomic DNA Translation: CAC33441.1
CR759828 Genomic DNA No translation available.
M28203 mRNA Translation: AAA53258.1
M83193 mRNA Translation: AAA58628.1
PIRiG01230
I38421
I62042
S16789
S24433
S77966
UniGeneiHs.654404
Hs.726974
Hs.77961

Genome annotation databases

EnsembliENST00000450871; ENSP00000388208; ENSG00000232126

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry namei1B15_HUMAN
AccessioniPrimary (citable) accession number: P30464
Secondary accession number(s): B0V0B8
, P30465, P30513, Q29633, Q29636, Q29829, Q29953, Q29982, Q95343, Q95344, Q9BD06
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: August 22, 2003
Last modified: March 28, 2018
This is version 160 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome