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P30464

- 1B15_HUMAN

UniProt

P30464 - 1B15_HUMAN

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Protein

HLA class I histocompatibility antigen, B-15 alpha chain

Gene

HLA-B

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Involved in the presentation of foreign antigens to the immune system.

GO - Molecular functioni

  1. peptide antigen binding Source: UniProt

GO - Biological processi

  1. antigen processing and presentation of exogenous peptide antigen via MHC class I Source: Reactome
  2. antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent Source: Reactome
  3. antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent Source: Reactome
  4. antigen processing and presentation of peptide antigen via MHC class I Source: Reactome
  5. cytokine-mediated signaling pathway Source: Reactome
  6. interferon-gamma-mediated signaling pathway Source: Reactome
  7. positive regulation of T cell mediated cytotoxicity Source: InterPro
  8. regulation of immune response Source: Reactome
  9. type I interferon signaling pathway Source: Reactome
  10. viral process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Host-virus interaction, Immunity

Enzyme and pathway databases

ReactomeiREACT_111168. Endosomal/Vacuolar pathway.
REACT_111178. ER-Phagosome pathway.
REACT_11152. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
REACT_25078. Interferon gamma signaling.
REACT_25162. Interferon alpha/beta signaling.
REACT_75795. Antigen Presentation: Folding, assembly and peptide loading of class I MHC.

Names & Taxonomyi

Protein namesi
Recommended name:
HLA class I histocompatibility antigen, B-15 alpha chain
Alternative name(s):
MHC class I antigen B*15
Gene namesi
Name:HLA-B
Synonyms:HLAB
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Unplaced

Organism-specific databases

HGNCiHGNC:4932. HLA-B.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini25 – 309285ExtracellularSequence AnalysisAdd
BLAST
Transmembranei310 – 33324HelicalSequence AnalysisAdd
BLAST
Topological domaini334 – 36229CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. cell surface Source: UniProt
  2. early endosome membrane Source: Reactome
  3. endoplasmic reticulum Source: UniProt
  4. ER to Golgi transport vesicle membrane Source: Reactome
  5. Golgi apparatus Source: UniProt
  6. Golgi membrane Source: Reactome
  7. integral component of lumenal side of endoplasmic reticulum membrane Source: Reactome
  8. MHC class I protein complex Source: UniProt
  9. phagocytic vesicle membrane Source: Reactome
  10. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane, MHC I

Pathology & Biotechi

Involvement in diseasei

Stevens-Johnson syndrome (SJS) [MIM:608579]: A rare blistering mucocutaneous disease that share clinical and histopathologic features with toxic epidermal necrolysis. Both disorders are characterized by high fever, malaise, and a rapidly developing blistering exanthema of macules and target-like lesions accompanied by mucosal involvement. Stevens-Johnson syndrome is a milder disease characterized by destruction and detachment of the skin epithelium and mucous membranes involving less than 10% of the body surface area. Ocular symptoms include ulcerative conjunctivitis, keratitis, iritis, uveitis and sometimes blindness. It can be caused by a severe adverse reaction to particular types of medication, although Mycoplasma infections may induce some cases.
Note: Disease susceptibility is associated with variations affecting the gene represented in this entry. Increased susceptibility to Stevens-Johnson syndrome is conferred by allele B*15:02.

Organism-specific databases

MIMi608579. phenotype.
Orphaneti240841. Abacavir toxicity.
240845. Allopurinol toxicity.
825. Ankylosing spondylitis.
117. Behcet disease.
240871. Flucloxacilline toxicity.
240901. Fosphenytoin toxicity.
240899. Phenytoin toxicity.
275798. Pulmonary arterial hypertension associated with connective tissue disease.
36426. Stevens-Johnson syndrome.
241001. Susceptibility to hepatitis due to flucloxacilline treatment.
241005. Susceptibility to hypersensitivity syndrome due to abacavir treatment.
241035. Susceptibility to toxic epidermal necrolysis due to allopurinol treatment.
241037. Susceptibility to toxic epidermal necrolysis due to carbamazepine treatment.
241039. Susceptibility to toxic epidermal necrolysis due to phenytoin treatment.
241041. Susceptibility to toxic epidermal necrolysis due to phosphenytoin treatment.
3287. Takayasu arteritis.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424Add
BLAST
Chaini25 – 362338HLA class I histocompatibility antigen, B-15 alpha chainPRO_0000018837Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi110 – 1101N-linked (GlcNAc...)By similarity
Disulfide bondi125 ↔ 1881 PublicationPROSITE-ProRule annotation
Disulfide bondi227 ↔ 2831 PublicationPROSITE-ProRule annotation

Post-translational modificationi

Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein. This targets the protein for rapid degradation via the ubiquitin system (By similarity).By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Ubl conjugation

Proteomic databases

MaxQBiP30464.
PRIDEiP30464.

Expressioni

Gene expression databases

CleanExiHS_HLA-B.
GenevestigatoriP30464.

Interactioni

Subunit structurei

Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8 MIR1 protein (By similarity).By similarity

Protein-protein interaction databases

IntActiP30464. 1 interaction.

Structurei

Secondary structure

1
362
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi27 – 3610Combined sources
Beta strandi41 – 433Combined sources
Beta strandi45 – 528Combined sources
Beta strandi55 – 617Combined sources
Beta strandi64 – 663Combined sources
Helixi74 – 763Combined sources
Helixi81 – 10828Combined sources
Beta strandi118 – 12710Combined sources
Beta strandi133 – 14210Combined sources
Beta strandi145 – 1506Combined sources
Beta strandi157 – 1615Combined sources
Helixi162 – 17312Combined sources
Helixi176 – 18510Combined sources
Helixi187 – 19812Combined sources
Helixi200 – 2034Combined sources
Beta strandi210 – 2178Combined sources
Beta strandi219 – 23517Combined sources
Beta strandi238 – 2436Combined sources
Helixi249 – 2513Combined sources
Beta strandi261 – 2633Combined sources
Beta strandi265 – 27410Combined sources
Helixi278 – 2803Combined sources
Beta strandi281 – 2866Combined sources
Beta strandi290 – 2923Combined sources
Beta strandi294 – 2963Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1XR8X-ray2.30A25-300[»]
1XR9X-ray1.79A25-300[»]
3C9NX-ray1.87A25-300[»]
ProteinModelPortaliP30464.
SMRiP30464. Positions 25-300.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP30464.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini209 – 29587Ig-like C1-typeAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni25 – 11490Alpha-1Add
BLAST
Regioni115 – 20692Alpha-2Add
BLAST
Regioni207 – 29892Alpha-3Add
BLAST
Regioni299 – 30911Connecting peptideAdd
BLAST

Sequence similaritiesi

Belongs to the MHC class I family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG016709.
OMAiNTRISEN.
PhylomeDBiP30464.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.30.500.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
IPR027648. MHC_I_a.
IPR001039. MHC_I_a_a1/a2.
IPR010579. MHC_I_a_C.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF00129. MHC_I. 1 hit.
PF06623. MHC_I_C. 1 hit.
[Graphical view]
PRINTSiPR01638. MHCCLASSI.
SMARTiSM00407. IGc1. 1 hit.
[Graphical view]
SUPFAMiSSF54452. SSF54452. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P30464-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRVTAPRTVL LLLSGALALT ETWAGSHSMR YFYTAMSRPG RGEPRFIAVG
60 70 80 90 100
YVDDTQFVRF DSDAASPRMA PRAPWIEQEG PEYWDRETQI SKTNTQTYRE
110 120 130 140 150
SLRNLRGYYN QSEAGSHTLQ RMYGCDVGPD GRLLRGHDQS AYDGKDYIAL
160 170 180 190 200
NEDLSSWTAA DTAAQITQRK WEAAREAEQW RAYLEGLCVE WLRRYLENGK
210 220 230 240 250
ETLQRADPPK THVTHHPISD HEATLRCWAL GFYPAEITLT WQRDGEDQTQ
260 270 280 290 300
DTELVETRPA GDRTFQKWAA VVVPSGEEQR YTCHVQHEGL PKPLTLRWEP
310 320 330 340 350
SSQSTIPIVG IVAGLAVLAV VVIGAVVATV MCRRKSSGGK GGSYSQAASS
360
DSAQGSDVSL TA
Length:362
Mass (Da):40,388
Last modified:August 22, 2003 - v2
Checksum:i86E938087372EBE0
GO

Polymorphismi

The following alleles of B-15 are known: B*15:01 (Bw-62; B-62), B*15:02 (Bw-75, B-75), B*15:03 (Bw-72; B-72; B-70) B*15:04, B*15:11, B*15:19 and B*15:66. The sequence shown is that of B*15:01.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti48 – 481A → S in allele B*15:03.
VAR_016365
Natural varianti69 – 702MA → EE in allele B*15:03.
VAR_016366
Natural varianti87 – 871E → N in allele B*15:02 and allele B*15:11; requires 2 nucleotide substitutions.
VAR_016367
Natural varianti91 – 911S → C in allele B*15:66.
VAR_016368
Natural varianti91 – 911S → Y in allele B*15:11.
VAR_016369
Natural varianti118 – 1192TL → II in allele B*15:02.
VAR_016370
Natural varianti119 – 1191L → W in allele B*15:04.
VAR_016371
Natural varianti121 – 1211R → T in allele B*15:04.
VAR_016372
Natural varianti137 – 1371H → Y in allele B*15:02.
VAR_016373
Natural varianti180 – 1801W → L in allele B*15:02 and allele B*15:03.
VAR_016374
Natural varianti190 – 1912EW → DG in allele B*15:19.
VAR_016375
Natural varianti274 – 2741P → L in allele B*15:19.
VAR_016376

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M75138 mRNA. Translation: AAA59630.1.
U03859 mRNA. Translation: AAA03601.1.
U03027 mRNA. Translation: AAA18902.1.
L11604 mRNA. Translation: AAA56836.1.
D50292 mRNA. Translation: BAA08823.1.
D50293 mRNA. Translation: BAA08824.1.
D50294 mRNA. Translation: BAA08825.1.
X61709 mRNA. Translation: CAA43878.1.
M84382 mRNA. Translation: AAA59632.1.
U70528 mRNA. Translation: AAB16918.1.
AJ295140 Genomic DNA. Translation: CAC17462.1.
AJ308399 Genomic DNA. Translation: CAC33441.1.
CR759828 Genomic DNA. Translation: CAQ10738.1.
M28203 mRNA. Translation: AAA53258.1.
M83193 mRNA. Translation: AAA58628.1.
PIRiG01230.
I38421.
I62042.
S16789.
S24433.
S77966.
UniGeneiHs.654404.
Hs.77961.

Genome annotation databases

EnsembliENST00000450871; ENSP00000388208; ENSG00000232126.
UCSCiuc011hpo.2. human.

Polymorphism databases

DMDMi34305703.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M75138 mRNA. Translation: AAA59630.1 .
U03859 mRNA. Translation: AAA03601.1 .
U03027 mRNA. Translation: AAA18902.1 .
L11604 mRNA. Translation: AAA56836.1 .
D50292 mRNA. Translation: BAA08823.1 .
D50293 mRNA. Translation: BAA08824.1 .
D50294 mRNA. Translation: BAA08825.1 .
X61709 mRNA. Translation: CAA43878.1 .
M84382 mRNA. Translation: AAA59632.1 .
U70528 mRNA. Translation: AAB16918.1 .
AJ295140 Genomic DNA. Translation: CAC17462.1 .
AJ308399 Genomic DNA. Translation: CAC33441.1 .
CR759828 Genomic DNA. Translation: CAQ10738.1 .
M28203 mRNA. Translation: AAA53258.1 .
M83193 mRNA. Translation: AAA58628.1 .
PIRi G01230.
I38421.
I62042.
S16789.
S24433.
S77966.
UniGenei Hs.654404.
Hs.77961.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1XR8 X-ray 2.30 A 25-300 [» ]
1XR9 X-ray 1.79 A 25-300 [» ]
3C9N X-ray 1.87 A 25-300 [» ]
ProteinModelPortali P30464.
SMRi P30464. Positions 25-300.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P30464. 1 interaction.

Polymorphism databases

DMDMi 34305703.

Proteomic databases

MaxQBi P30464.
PRIDEi P30464.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000450871 ; ENSP00000388208 ; ENSG00000232126 .
UCSCi uc011hpo.2. human.

Organism-specific databases

GeneCardsi GC06M031321.
GC06Mm31398.
HGNCi HGNC:4932. HLA-B.
MIMi 142830. gene.
608579. phenotype.
neXtProti NX_P30464.
Orphaneti 240841. Abacavir toxicity.
240845. Allopurinol toxicity.
825. Ankylosing spondylitis.
117. Behcet disease.
240871. Flucloxacilline toxicity.
240901. Fosphenytoin toxicity.
240899. Phenytoin toxicity.
275798. Pulmonary arterial hypertension associated with connective tissue disease.
36426. Stevens-Johnson syndrome.
241001. Susceptibility to hepatitis due to flucloxacilline treatment.
241005. Susceptibility to hypersensitivity syndrome due to abacavir treatment.
241035. Susceptibility to toxic epidermal necrolysis due to allopurinol treatment.
241037. Susceptibility to toxic epidermal necrolysis due to carbamazepine treatment.
241039. Susceptibility to toxic epidermal necrolysis due to phenytoin treatment.
241041. Susceptibility to toxic epidermal necrolysis due to phosphenytoin treatment.
3287. Takayasu arteritis.
GenAtlasi Search...

Phylogenomic databases

HOVERGENi HBG016709.
OMAi NTRISEN.
PhylomeDBi P30464.

Enzyme and pathway databases

Reactomei REACT_111168. Endosomal/Vacuolar pathway.
REACT_111178. ER-Phagosome pathway.
REACT_11152. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
REACT_25078. Interferon gamma signaling.
REACT_25162. Interferon alpha/beta signaling.
REACT_75795. Antigen Presentation: Folding, assembly and peptide loading of class I MHC.

Miscellaneous databases

ChiTaRSi HLA-B. human.
EvolutionaryTracei P30464.
SOURCEi Search...

Gene expression databases

CleanExi HS_HLA-B.
Genevestigatori P30464.

Family and domain databases

Gene3Di 2.60.40.10. 1 hit.
3.30.500.10. 1 hit.
InterProi IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
IPR027648. MHC_I_a.
IPR001039. MHC_I_a_a1/a2.
IPR010579. MHC_I_a_C.
[Graphical view ]
Pfami PF07654. C1-set. 1 hit.
PF00129. MHC_I. 1 hit.
PF06623. MHC_I_C. 1 hit.
[Graphical view ]
PRINTSi PR01638. MHCCLASSI.
SMARTi SM00407. IGc1. 1 hit.
[Graphical view ]
SUPFAMi SSF54452. SSF54452. 1 hit.
PROSITEi PS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The HLA-Bw75 subtype of B15: molecular characterization and comparison with crossreacting antigens."
    Little A.-M., Parham P.
    Tissue Antigens 38:186-190(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE B*15:02).
  2. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELES B*15:01; B*15:11 AND B*15:19).
  3. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELES B*15:01; B*15:02 AND B*15:11).
    Tissue: Blood.
  4. "Distinctive HLA-A,B antigens of black populations formed by interallelic conversion."
    Madrigal J.A., Belich M.P., Hildebrand W.H., Benjamin R.J., Little A.-M., Zemmour J., Ennis P.D., Ward F.E., Petzl-Erler M.L., Martell R.W., du Toit E.D., Parham P.
    J. Immunol. 149:3411-3415(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE (ALLELE B*15:03).
  5. "New recombinant HLA-B alleles in a tribe of South American Amerindians indicate rapid evolution of MHC class I loci."
    Watkins D.I., McAdam S.N., Liu X., Stang C.R., Milford E.L., Levine C.G., Garber T.L., Dogon A.L., Lord C.I., Ghim S.H., Troup G.M., Hughes A.L., Letvin N.L.
    Nature 357:329-333(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE (ALLELE B*15:04).
  6. Ramos M., Barber D.F., Layrisse Z., de Castro J.A.
    Submitted (OCT-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE (ALLELE B*15:04).
    Tissue: Blood.
  7. Cited for: NUCLEOTIDE SEQUENCE (ALLELE B*15:01).
    Tissue: Blood.
  8. Cited for: NUCLEOTIDE SEQUENCE (ALLELE B*15:66).
  9. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  10. "Allelic variation in HLA-B and HLA-C sequences and the evolution of the HLA-B alleles."
    Pohla H., Kuon W., Tabaczewski P., Doerner C., Weiss E.H.
    Immunogenetics 29:297-307(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 5-362 (ALLELE B*15:01).
  11. "Allelic variations clustered in the antigen binding sites of HLA-Bw62 molecules."
    Choo S.Y., Fan L.A., Hansen J.A.
    Immunogenetics 37:108-113(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 25-362 (ALLELE B*15:01).
  12. Cited for: ASSOCIATION OF ALLELE B*15:02 WITH STEVENS-JOHNSON SYNDROME.
  13. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  14. "Crystal structures of two peptide-HLA-B*1501 complexes; structural characterization of the HLA-B62 supertype."
    Roder G., Blicher T., Justesen S., Johannesen B., Kristensen O., Kastrup J., Buus S., Gajhede M.
    Acta Crystallogr. D 62:1300-1310(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.79 ANGSTROMS) OF 25-300 (ALLELE B*15:01) IN COMPLEX WITH EBV NUCLEAR ANTIGEN AND UBE2 PEPTIDES, DISULFIDE BONDS.

Entry informationi

Entry namei1B15_HUMAN
AccessioniPrimary (citable) accession number: P30464
Secondary accession number(s): B0V0B8
, P30465, P30513, Q29633, Q29636, Q29829, Q29953, Q29982, Q95343, Q95344, Q9BD06
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: August 22, 2003
Last modified: November 26, 2014
This is version 132 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

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