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Protein

HLA class I histocompatibility antigen, B-15 alpha chain

Gene

HLA-B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the presentation of foreign antigens to the immune system.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Host-virus interaction, Immunity

Enzyme and pathway databases

ReactomeiR-HSA-1236974. ER-Phagosome pathway.
R-HSA-1236977. Endosomal/Vacuolar pathway.
R-HSA-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
R-HSA-877300. Interferon gamma signaling.
R-HSA-909733. Interferon alpha/beta signaling.
R-HSA-983170. Antigen Presentation: Folding, assembly and peptide loading of class I MHC.

Names & Taxonomyi

Protein namesi
Recommended name:
HLA class I histocompatibility antigen, B-15 alpha chain
Alternative name(s):
MHC class I antigen B*15
Gene namesi
Name:HLA-B
Synonyms:HLAB
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:4932. HLA-B.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini25 – 309ExtracellularSequence analysisAdd BLAST285
Transmembranei310 – 333HelicalSequence analysisAdd BLAST24
Topological domaini334 – 362CytoplasmicSequence analysisAdd BLAST29

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, MHC I

Pathology & Biotechi

Involvement in diseasei

Stevens-Johnson syndrome (SJS)
Disease susceptibility is associated with variations affecting the gene represented in this entry. Increased susceptibility to Stevens-Johnson syndrome is conferred by allele B*15:02.
Disease descriptionA rare blistering mucocutaneous disease that share clinical and histopathologic features with toxic epidermal necrolysis. Both disorders are characterized by high fever, malaise, and a rapidly developing blistering exanthema of macules and target-like lesions accompanied by mucosal involvement. Stevens-Johnson syndrome is a milder disease characterized by destruction and detachment of the skin epithelium and mucous membranes involving less than 10% of the body surface area. Ocular symptoms include ulcerative conjunctivitis, keratitis, iritis, uveitis and sometimes blindness. It can be caused by a severe adverse reaction to particular types of medication, although Mycoplasma infections may induce some cases.
See also OMIM:608579

Organism-specific databases

MalaCardsiHLA-B.
MIMi608579. phenotype.
OpenTargetsiENSG00000232126.
Orphaneti240841. Abacavir toxicity.
240845. Allopurinol toxicity.
825. Ankylosing spondylitis.
117. Behcet disease.
240871. Flucloxacilline toxicity.
414750. Phenytoin or carbamazepine toxicity.
275798. Pulmonary arterial hypertension associated with connective tissue disease.
36426. Stevens-Johnson syndrome.
3287. Takayasu arteritis.

Polymorphism and mutation databases

DMDMi34305703.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Add BLAST24
ChainiPRO_000001883725 – 362HLA class I histocompatibility antigen, B-15 alpha chainAdd BLAST338

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi110N-linked (GlcNAc...)By similarity1
Disulfide bondi125 ↔ 188PROSITE-ProRule annotation1 Publication
Disulfide bondi227 ↔ 283PROSITE-ProRule annotation1 Publication

Post-translational modificationi

Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein. This targets the protein for rapid degradation via the ubiquitin system (By similarity).By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Ubl conjugation

Proteomic databases

MaxQBiP30464.
PeptideAtlasiP30464.
PRIDEiP30464.

PTM databases

SwissPalmiP30464.

Expressioni

Gene expression databases

BgeeiENSG00000232126.
CleanExiHS_HLA-B.

Interactioni

Subunit structurei

Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8 MIR1 protein (By similarity).By similarity

Protein-protein interaction databases

IntActiP30464. 1 interactor.

Structurei

Secondary structure

1362
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi27 – 36Combined sources10
Beta strandi41 – 43Combined sources3
Beta strandi45 – 52Combined sources8
Beta strandi55 – 61Combined sources7
Beta strandi64 – 66Combined sources3
Helixi74 – 76Combined sources3
Helixi81 – 108Combined sources28
Beta strandi118 – 127Combined sources10
Beta strandi133 – 142Combined sources10
Beta strandi145 – 150Combined sources6
Beta strandi157 – 161Combined sources5
Helixi162 – 173Combined sources12
Helixi176 – 185Combined sources10
Helixi187 – 198Combined sources12
Helixi200 – 203Combined sources4
Beta strandi210 – 217Combined sources8
Beta strandi219 – 235Combined sources17
Beta strandi238 – 243Combined sources6
Helixi249 – 251Combined sources3
Beta strandi261 – 263Combined sources3
Beta strandi265 – 274Combined sources10
Helixi278 – 280Combined sources3
Beta strandi281 – 286Combined sources6
Beta strandi290 – 292Combined sources3
Beta strandi294 – 296Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1XR8X-ray2.30A25-300[»]
1XR9X-ray1.79A25-300[»]
3C9NX-ray1.87A25-300[»]
ProteinModelPortaliP30464.
SMRiP30464.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP30464.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini209 – 295Ig-like C1-typeAdd BLAST87

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni25 – 114Alpha-1Add BLAST90
Regioni115 – 206Alpha-2Add BLAST92
Regioni207 – 298Alpha-3Add BLAST92
Regioni299 – 309Connecting peptideAdd BLAST11

Sequence similaritiesi

Belongs to the MHC class I family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG016709.
OMAiPCVGLRC.
OrthoDBiEOG091G09OH.
PhylomeDBiP30464.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.30.500.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
IPR001039. MHC_I_a_a1/a2.
IPR010579. MHC_I_a_C.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF00129. MHC_I. 1 hit.
PF06623. MHC_I_C. 1 hit.
[Graphical view]
PRINTSiPR01638. MHCCLASSI.
SMARTiSM00407. IGc1. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF54452. SSF54452. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P30464-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRVTAPRTVL LLLSGALALT ETWAGSHSMR YFYTAMSRPG RGEPRFIAVG
60 70 80 90 100
YVDDTQFVRF DSDAASPRMA PRAPWIEQEG PEYWDRETQI SKTNTQTYRE
110 120 130 140 150
SLRNLRGYYN QSEAGSHTLQ RMYGCDVGPD GRLLRGHDQS AYDGKDYIAL
160 170 180 190 200
NEDLSSWTAA DTAAQITQRK WEAAREAEQW RAYLEGLCVE WLRRYLENGK
210 220 230 240 250
ETLQRADPPK THVTHHPISD HEATLRCWAL GFYPAEITLT WQRDGEDQTQ
260 270 280 290 300
DTELVETRPA GDRTFQKWAA VVVPSGEEQR YTCHVQHEGL PKPLTLRWEP
310 320 330 340 350
SSQSTIPIVG IVAGLAVLAV VVIGAVVATV MCRRKSSGGK GGSYSQAASS
360
DSAQGSDVSL TA
Length:362
Mass (Da):40,388
Last modified:August 22, 2003 - v2
Checksum:i86E938087372EBE0
GO

Polymorphismi

The following alleles of B-15 are known: B*15:01 (Bw-62; B-62), B*15:02 (Bw-75, B-75), B*15:03 (Bw-72; B-72; B-70) B*15:04, B*15:11, B*15:19 and B*15:66. The sequence shown is that of B*15:01.

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01636548A → S in allele B*15:03. Corresponds to variant rs713031dbSNPEnsembl.1
Natural variantiVAR_01636669 – 70MA → EE in allele B*15:03. 2
Natural variantiVAR_01636787E → N in allele B*15:02 and allele B*15:11; requires 2 nucleotide substitutions. 1
Natural variantiVAR_01636891S → C in allele B*15:66. Corresponds to variant rs1071816dbSNPEnsembl.1
Natural variantiVAR_01636991S → Y in allele B*15:11. Corresponds to variant rs1071816dbSNPEnsembl.1
Natural variantiVAR_016370118 – 119TL → II in allele B*15:02. Corresponds to variant rs796332753dbSNPEnsembl.2
Natural variantiVAR_016371119L → W in allele B*15:04. 1
Natural variantiVAR_016372121R → T in allele B*15:04. Corresponds to variant rs1071652dbSNPEnsembl.1
Natural variantiVAR_016373137H → Y in allele B*15:02. Corresponds to variant rs1050379dbSNPEnsembl.1
Natural variantiVAR_016374180W → L in allele B*15:02 and allele B*15:03. Corresponds to variant rs697742dbSNPEnsembl.1
Natural variantiVAR_016375190 – 191EW → DG in allele B*15:19. 2
Natural variantiVAR_016376274P → L in allele B*15:19. Corresponds to variant rs41545517dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M75138 mRNA. Translation: AAA59630.1.
U03859 mRNA. Translation: AAA03601.1.
U03027 mRNA. Translation: AAA18902.1.
L11604 mRNA. Translation: AAA56836.1.
D50292 mRNA. Translation: BAA08823.1.
D50293 mRNA. Translation: BAA08824.1.
D50294 mRNA. Translation: BAA08825.1.
X61709 mRNA. Translation: CAA43878.1.
M84382 mRNA. Translation: AAA59632.1.
U70528 mRNA. Translation: AAB16918.1.
AJ295140 Genomic DNA. Translation: CAC17462.1.
AJ308399 Genomic DNA. Translation: CAC33441.1.
CR759828 Genomic DNA. Translation: CAQ10738.1.
M28203 mRNA. Translation: AAA53258.1.
M83193 mRNA. Translation: AAA58628.1.
PIRiG01230.
I38421.
I62042.
S16789.
S24433.
S77966.
UniGeneiHs.654404.
Hs.726974.
Hs.77961.

Genome annotation databases

EnsembliENST00000450871; ENSP00000388208; ENSG00000232126.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M75138 mRNA. Translation: AAA59630.1.
U03859 mRNA. Translation: AAA03601.1.
U03027 mRNA. Translation: AAA18902.1.
L11604 mRNA. Translation: AAA56836.1.
D50292 mRNA. Translation: BAA08823.1.
D50293 mRNA. Translation: BAA08824.1.
D50294 mRNA. Translation: BAA08825.1.
X61709 mRNA. Translation: CAA43878.1.
M84382 mRNA. Translation: AAA59632.1.
U70528 mRNA. Translation: AAB16918.1.
AJ295140 Genomic DNA. Translation: CAC17462.1.
AJ308399 Genomic DNA. Translation: CAC33441.1.
CR759828 Genomic DNA. Translation: CAQ10738.1.
M28203 mRNA. Translation: AAA53258.1.
M83193 mRNA. Translation: AAA58628.1.
PIRiG01230.
I38421.
I62042.
S16789.
S24433.
S77966.
UniGeneiHs.654404.
Hs.726974.
Hs.77961.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1XR8X-ray2.30A25-300[»]
1XR9X-ray1.79A25-300[»]
3C9NX-ray1.87A25-300[»]
ProteinModelPortaliP30464.
SMRiP30464.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP30464. 1 interactor.

PTM databases

SwissPalmiP30464.

Polymorphism and mutation databases

DMDMi34305703.

Proteomic databases

MaxQBiP30464.
PeptideAtlasiP30464.
PRIDEiP30464.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000450871; ENSP00000388208; ENSG00000232126.

Organism-specific databases

GeneCardsiHLA-B.
HGNCiHGNC:4932. HLA-B.
MalaCardsiHLA-B.
MIMi142830. gene.
608579. phenotype.
neXtProtiNX_P30464.
OpenTargetsiENSG00000232126.
Orphaneti240841. Abacavir toxicity.
240845. Allopurinol toxicity.
825. Ankylosing spondylitis.
117. Behcet disease.
240871. Flucloxacilline toxicity.
414750. Phenytoin or carbamazepine toxicity.
275798. Pulmonary arterial hypertension associated with connective tissue disease.
36426. Stevens-Johnson syndrome.
3287. Takayasu arteritis.
GenAtlasiSearch...

Phylogenomic databases

HOVERGENiHBG016709.
OMAiPCVGLRC.
OrthoDBiEOG091G09OH.
PhylomeDBiP30464.

Enzyme and pathway databases

ReactomeiR-HSA-1236974. ER-Phagosome pathway.
R-HSA-1236977. Endosomal/Vacuolar pathway.
R-HSA-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
R-HSA-877300. Interferon gamma signaling.
R-HSA-909733. Interferon alpha/beta signaling.
R-HSA-983170. Antigen Presentation: Folding, assembly and peptide loading of class I MHC.

Miscellaneous databases

ChiTaRSiHLA-B. human.
EvolutionaryTraceiP30464.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000232126.
CleanExiHS_HLA-B.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.30.500.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
IPR001039. MHC_I_a_a1/a2.
IPR010579. MHC_I_a_C.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF00129. MHC_I. 1 hit.
PF06623. MHC_I_C. 1 hit.
[Graphical view]
PRINTSiPR01638. MHCCLASSI.
SMARTiSM00407. IGc1. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF54452. SSF54452. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry namei1B15_HUMAN
AccessioniPrimary (citable) accession number: P30464
Secondary accession number(s): B0V0B8
, P30465, P30513, Q29633, Q29636, Q29829, Q29953, Q29982, Q95343, Q95344, Q9BD06
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: August 22, 2003
Last modified: November 2, 2016
This is version 150 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.