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P30464

- 1B15_HUMAN

UniProt

P30464 - 1B15_HUMAN

Protein

HLA class I histocompatibility antigen, B-15 alpha chain

Gene

HLA-B

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 130 (01 Oct 2014)
      Sequence version 2 (22 Aug 2003)
      Previous versions | rss
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    Functioni

    Involved in the presentation of foreign antigens to the immune system.

    GO - Molecular functioni

    1. peptide antigen binding Source: UniProt

    GO - Biological processi

    1. antigen processing and presentation of exogenous peptide antigen via MHC class I Source: Reactome
    2. antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent Source: Reactome
    3. antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent Source: Reactome
    4. antigen processing and presentation of peptide antigen via MHC class I Source: Reactome
    5. cytokine-mediated signaling pathway Source: Reactome
    6. interferon-gamma-mediated signaling pathway Source: Reactome
    7. positive regulation of T cell mediated cytotoxicity Source: InterPro
    8. regulation of immune response Source: Reactome
    9. type I interferon signaling pathway Source: Reactome
    10. viral process Source: UniProtKB-KW

    Keywords - Biological processi

    Host-virus interaction, Immunity

    Enzyme and pathway databases

    ReactomeiREACT_111168. Endosomal/Vacuolar pathway.
    REACT_111178. ER-Phagosome pathway.
    REACT_11152. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
    REACT_25078. Interferon gamma signaling.
    REACT_25162. Interferon alpha/beta signaling.
    REACT_75795. Antigen Presentation: Folding, assembly and peptide loading of class I MHC.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    HLA class I histocompatibility antigen, B-15 alpha chain
    Alternative name(s):
    MHC class I antigen B*15
    Gene namesi
    Name:HLA-B
    Synonyms:HLAB
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Unplaced

    Organism-specific databases

    HGNCiHGNC:4932. HLA-B.

    Subcellular locationi

    GO - Cellular componenti

    1. cell surface Source: UniProt
    2. early endosome membrane Source: Reactome
    3. endoplasmic reticulum Source: UniProt
    4. ER to Golgi transport vesicle membrane Source: Reactome
    5. Golgi apparatus Source: UniProt
    6. Golgi membrane Source: Reactome
    7. integral component of lumenal side of endoplasmic reticulum membrane Source: Reactome
    8. MHC class I protein complex Source: UniProt
    9. phagocytic vesicle membrane Source: Reactome
    10. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Membrane, MHC I

    Pathology & Biotechi

    Involvement in diseasei

    Stevens-Johnson syndrome (SJS) [MIM:608579]: A rare blistering mucocutaneous disease that share clinical and histopathologic features with toxic epidermal necrolysis. Both disorders are characterized by high fever, malaise, and a rapidly developing blistering exanthema of macules and target-like lesions accompanied by mucosal involvement. Stevens-Johnson syndrome is a milder disease characterized by destruction and detachment of the skin epithelium and mucous membranes involving less than 10% of the body surface area. Ocular symptoms include ulcerative conjunctivitis, keratitis, iritis, uveitis and sometimes blindness. It can be caused by a severe adverse reaction to particular types of medication, although Mycoplasma infections may induce some cases.
    Note: Disease susceptibility is associated with variations affecting the gene represented in this entry. Increased susceptibility to Stevens-Johnson syndrome is conferred by allele B*15:02.

    Organism-specific databases

    MIMi608579. phenotype.
    Orphaneti240841. Abacavir toxicity.
    240845. Allopurinol toxicity.
    825. Ankylosing spondylitis.
    117. Behcet disease.
    240871. Flucloxacilline toxicity.
    240901. Fosphenytoin toxicity.
    240899. Phenytoin toxicity.
    275798. Pulmonary arterial hypertension associated with connective tissue disease.
    36426. Stevens-Johnson syndrome.
    241001. Susceptibility to hepatitis due to flucloxacilline treatment.
    241005. Susceptibility to hypersensitivity syndrome due to abacavir treatment.
    241035. Susceptibility to toxic epidermal necrolysis due to allopurinol treatment.
    241037. Susceptibility to toxic epidermal necrolysis due to carbamazepine treatment.
    241039. Susceptibility to toxic epidermal necrolysis due to phenytoin treatment.
    241041. Susceptibility to toxic epidermal necrolysis due to phosphenytoin treatment.
    3287. Takayasu arteritis.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2424Add
    BLAST
    Chaini25 – 362338HLA class I histocompatibility antigen, B-15 alpha chainPRO_0000018837Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi110 – 1101N-linked (GlcNAc...)By similarity
    Disulfide bondi125 ↔ 1881 PublicationPROSITE-ProRule annotation
    Disulfide bondi227 ↔ 2831 PublicationPROSITE-ProRule annotation

    Post-translational modificationi

    Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein. This targets the protein for rapid degradation via the ubiquitin system By similarity.By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Ubl conjugation

    Proteomic databases

    MaxQBiP30464.
    PRIDEiP30464.

    Expressioni

    Gene expression databases

    CleanExiHS_HLA-B.
    GenevestigatoriP30464.

    Interactioni

    Subunit structurei

    Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8 MIR1 protein By similarity.By similarity

    Protein-protein interaction databases

    IntActiP30464. 1 interaction.

    Structurei

    Secondary structure

    1
    362
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi27 – 3610
    Beta strandi41 – 433
    Beta strandi45 – 528
    Beta strandi55 – 617
    Beta strandi64 – 663
    Helixi74 – 763
    Helixi81 – 10828
    Beta strandi118 – 12710
    Beta strandi133 – 14210
    Beta strandi145 – 1506
    Beta strandi157 – 1615
    Helixi162 – 17312
    Helixi176 – 18510
    Helixi187 – 19812
    Helixi200 – 2034
    Beta strandi210 – 2178
    Beta strandi219 – 23517
    Beta strandi238 – 2436
    Helixi249 – 2513
    Beta strandi261 – 2633
    Beta strandi265 – 27410
    Helixi278 – 2803
    Beta strandi281 – 2866
    Beta strandi290 – 2923
    Beta strandi294 – 2963

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1XR8X-ray2.30A25-300[»]
    1XR9X-ray1.79A25-300[»]
    3C9NX-ray1.87A25-300[»]
    ProteinModelPortaliP30464.
    SMRiP30464. Positions 25-300.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP30464.

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini25 – 309285ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini334 – 36229CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei310 – 33324HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini209 – 29587Ig-like C1-typeAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni25 – 11490Alpha-1Add
    BLAST
    Regioni115 – 20692Alpha-2Add
    BLAST
    Regioni207 – 29892Alpha-3Add
    BLAST
    Regioni299 – 30911Connecting peptideAdd
    BLAST

    Sequence similaritiesi

    Belongs to the MHC class I family.Curated

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    HOVERGENiHBG016709.
    InParanoidiP30464.
    OMAiNTRISEN.
    PhylomeDBiP30464.

    Family and domain databases

    Gene3Di2.60.40.10. 1 hit.
    3.30.500.10. 1 hit.
    InterProiIPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003006. Ig/MHC_CS.
    IPR003597. Ig_C1-set.
    IPR011161. MHC_I-like_Ag-recog.
    IPR011162. MHC_I/II-like_Ag-recog.
    IPR027648. MHC_I_a.
    IPR001039. MHC_I_a_a1/a2.
    IPR010579. MHC_I_a_C.
    [Graphical view]
    PfamiPF07654. C1-set. 1 hit.
    PF00129. MHC_I. 1 hit.
    PF06623. MHC_I_C. 1 hit.
    [Graphical view]
    PRINTSiPR01638. MHCCLASSI.
    SMARTiSM00407. IGc1. 1 hit.
    [Graphical view]
    SUPFAMiSSF54452. SSF54452. 1 hit.
    PROSITEiPS50835. IG_LIKE. 1 hit.
    PS00290. IG_MHC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P30464-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRVTAPRTVL LLLSGALALT ETWAGSHSMR YFYTAMSRPG RGEPRFIAVG    50
    YVDDTQFVRF DSDAASPRMA PRAPWIEQEG PEYWDRETQI SKTNTQTYRE 100
    SLRNLRGYYN QSEAGSHTLQ RMYGCDVGPD GRLLRGHDQS AYDGKDYIAL 150
    NEDLSSWTAA DTAAQITQRK WEAAREAEQW RAYLEGLCVE WLRRYLENGK 200
    ETLQRADPPK THVTHHPISD HEATLRCWAL GFYPAEITLT WQRDGEDQTQ 250
    DTELVETRPA GDRTFQKWAA VVVPSGEEQR YTCHVQHEGL PKPLTLRWEP 300
    SSQSTIPIVG IVAGLAVLAV VVIGAVVATV MCRRKSSGGK GGSYSQAASS 350
    DSAQGSDVSL TA 362
    Length:362
    Mass (Da):40,388
    Last modified:August 22, 2003 - v2
    Checksum:i86E938087372EBE0
    GO

    Polymorphismi

    The following alleles of B-15 are known: B*15:01 (Bw-62; B-62), B*15:02 (Bw-75, B-75), B*15:03 (Bw-72; B-72; B-70) B*15:04, B*15:11, B*15:19 and B*15:66. The sequence shown is that of B*15:01.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti48 – 481A → S in allele B*15:03.
    VAR_016365
    Natural varianti69 – 702MA → EE in allele B*15:03.
    VAR_016366
    Natural varianti87 – 871E → N in allele B*15:02 and allele B*15:11; requires 2 nucleotide substitutions.
    VAR_016367
    Natural varianti91 – 911S → C in allele B*15:66.
    VAR_016368
    Natural varianti91 – 911S → Y in allele B*15:11.
    VAR_016369
    Natural varianti118 – 1192TL → II in allele B*15:02.
    VAR_016370
    Natural varianti119 – 1191L → W in allele B*15:04.
    VAR_016371
    Natural varianti121 – 1211R → T in allele B*15:04.
    VAR_016372
    Natural varianti137 – 1371H → Y in allele B*15:02.
    VAR_016373
    Natural varianti180 – 1801W → L in allele B*15:02 and allele B*15:03.
    VAR_016374
    Natural varianti190 – 1912EW → DG in allele B*15:19.
    VAR_016375
    Natural varianti274 – 2741P → L in allele B*15:19.
    VAR_016376

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M75138 mRNA. Translation: AAA59630.1.
    U03859 mRNA. Translation: AAA03601.1.
    U03027 mRNA. Translation: AAA18902.1.
    L11604 mRNA. Translation: AAA56836.1.
    D50292 mRNA. Translation: BAA08823.1.
    D50293 mRNA. Translation: BAA08824.1.
    D50294 mRNA. Translation: BAA08825.1.
    X61709 mRNA. Translation: CAA43878.1.
    M84382 mRNA. Translation: AAA59632.1.
    U70528 mRNA. Translation: AAB16918.1.
    AJ295140 Genomic DNA. Translation: CAC17462.1.
    AJ308399 Genomic DNA. Translation: CAC33441.1.
    CR759828 Genomic DNA. Translation: CAQ10738.1.
    M28203 mRNA. Translation: AAA53258.1.
    M83193 mRNA. Translation: AAA58628.1.
    PIRiG01230.
    I38421.
    I62042.
    S16789.
    S24433.
    S77966.
    UniGeneiHs.654404.
    Hs.77961.

    Genome annotation databases

    EnsembliENST00000450871; ENSP00000388208; ENSG00000232126.
    UCSCiuc011hpo.2. human.

    Polymorphism databases

    DMDMi34305703.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M75138 mRNA. Translation: AAA59630.1 .
    U03859 mRNA. Translation: AAA03601.1 .
    U03027 mRNA. Translation: AAA18902.1 .
    L11604 mRNA. Translation: AAA56836.1 .
    D50292 mRNA. Translation: BAA08823.1 .
    D50293 mRNA. Translation: BAA08824.1 .
    D50294 mRNA. Translation: BAA08825.1 .
    X61709 mRNA. Translation: CAA43878.1 .
    M84382 mRNA. Translation: AAA59632.1 .
    U70528 mRNA. Translation: AAB16918.1 .
    AJ295140 Genomic DNA. Translation: CAC17462.1 .
    AJ308399 Genomic DNA. Translation: CAC33441.1 .
    CR759828 Genomic DNA. Translation: CAQ10738.1 .
    M28203 mRNA. Translation: AAA53258.1 .
    M83193 mRNA. Translation: AAA58628.1 .
    PIRi G01230.
    I38421.
    I62042.
    S16789.
    S24433.
    S77966.
    UniGenei Hs.654404.
    Hs.77961.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1XR8 X-ray 2.30 A 25-300 [» ]
    1XR9 X-ray 1.79 A 25-300 [» ]
    3C9N X-ray 1.87 A 25-300 [» ]
    ProteinModelPortali P30464.
    SMRi P30464. Positions 25-300.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P30464. 1 interaction.

    Polymorphism databases

    DMDMi 34305703.

    Proteomic databases

    MaxQBi P30464.
    PRIDEi P30464.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000450871 ; ENSP00000388208 ; ENSG00000232126 .
    UCSCi uc011hpo.2. human.

    Organism-specific databases

    GeneCardsi GC06M031321.
    GC06Mm31398.
    HGNCi HGNC:4932. HLA-B.
    MIMi 142830. gene.
    608579. phenotype.
    neXtProti NX_P30464.
    Orphaneti 240841. Abacavir toxicity.
    240845. Allopurinol toxicity.
    825. Ankylosing spondylitis.
    117. Behcet disease.
    240871. Flucloxacilline toxicity.
    240901. Fosphenytoin toxicity.
    240899. Phenytoin toxicity.
    275798. Pulmonary arterial hypertension associated with connective tissue disease.
    36426. Stevens-Johnson syndrome.
    241001. Susceptibility to hepatitis due to flucloxacilline treatment.
    241005. Susceptibility to hypersensitivity syndrome due to abacavir treatment.
    241035. Susceptibility to toxic epidermal necrolysis due to allopurinol treatment.
    241037. Susceptibility to toxic epidermal necrolysis due to carbamazepine treatment.
    241039. Susceptibility to toxic epidermal necrolysis due to phenytoin treatment.
    241041. Susceptibility to toxic epidermal necrolysis due to phosphenytoin treatment.
    3287. Takayasu arteritis.
    GenAtlasi Search...

    Phylogenomic databases

    HOVERGENi HBG016709.
    InParanoidi P30464.
    OMAi NTRISEN.
    PhylomeDBi P30464.

    Enzyme and pathway databases

    Reactomei REACT_111168. Endosomal/Vacuolar pathway.
    REACT_111178. ER-Phagosome pathway.
    REACT_11152. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
    REACT_25078. Interferon gamma signaling.
    REACT_25162. Interferon alpha/beta signaling.
    REACT_75795. Antigen Presentation: Folding, assembly and peptide loading of class I MHC.

    Miscellaneous databases

    ChiTaRSi HLA-B. human.
    EvolutionaryTracei P30464.
    SOURCEi Search...

    Gene expression databases

    CleanExi HS_HLA-B.
    Genevestigatori P30464.

    Family and domain databases

    Gene3Di 2.60.40.10. 1 hit.
    3.30.500.10. 1 hit.
    InterProi IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003006. Ig/MHC_CS.
    IPR003597. Ig_C1-set.
    IPR011161. MHC_I-like_Ag-recog.
    IPR011162. MHC_I/II-like_Ag-recog.
    IPR027648. MHC_I_a.
    IPR001039. MHC_I_a_a1/a2.
    IPR010579. MHC_I_a_C.
    [Graphical view ]
    Pfami PF07654. C1-set. 1 hit.
    PF00129. MHC_I. 1 hit.
    PF06623. MHC_I_C. 1 hit.
    [Graphical view ]
    PRINTSi PR01638. MHCCLASSI.
    SMARTi SM00407. IGc1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54452. SSF54452. 1 hit.
    PROSITEi PS50835. IG_LIKE. 1 hit.
    PS00290. IG_MHC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The HLA-Bw75 subtype of B15: molecular characterization and comparison with crossreacting antigens."
      Little A.-M., Parham P.
      Tissue Antigens 38:186-190(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE B*15:02).
    2. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELES B*15:01; B*15:11 AND B*15:19).
    3. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELES B*15:01; B*15:02 AND B*15:11).
      Tissue: Blood.
    4. "Distinctive HLA-A,B antigens of black populations formed by interallelic conversion."
      Madrigal J.A., Belich M.P., Hildebrand W.H., Benjamin R.J., Little A.-M., Zemmour J., Ennis P.D., Ward F.E., Petzl-Erler M.L., Martell R.W., du Toit E.D., Parham P.
      J. Immunol. 149:3411-3415(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE (ALLELE B*15:03).
    5. "New recombinant HLA-B alleles in a tribe of South American Amerindians indicate rapid evolution of MHC class I loci."
      Watkins D.I., McAdam S.N., Liu X., Stang C.R., Milford E.L., Levine C.G., Garber T.L., Dogon A.L., Lord C.I., Ghim S.H., Troup G.M., Hughes A.L., Letvin N.L.
      Nature 357:329-333(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE (ALLELE B*15:04).
    6. Ramos M., Barber D.F., Layrisse Z., de Castro J.A.
      Submitted (OCT-1996) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE (ALLELE B*15:04).
      Tissue: Blood.
    7. Cited for: NUCLEOTIDE SEQUENCE (ALLELE B*15:01).
      Tissue: Blood.
    8. Cited for: NUCLEOTIDE SEQUENCE (ALLELE B*15:66).
    9. "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
      Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    10. "Allelic variation in HLA-B and HLA-C sequences and the evolution of the HLA-B alleles."
      Pohla H., Kuon W., Tabaczewski P., Doerner C., Weiss E.H.
      Immunogenetics 29:297-307(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 5-362 (ALLELE B*15:01).
    11. "Allelic variations clustered in the antigen binding sites of HLA-Bw62 molecules."
      Choo S.Y., Fan L.A., Hansen J.A.
      Immunogenetics 37:108-113(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 25-362 (ALLELE B*15:01).
    12. Cited for: ASSOCIATION OF ALLELE B*15:02 WITH STEVENS-JOHNSON SYNDROME.
    13. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    14. "Crystal structures of two peptide-HLA-B*1501 complexes; structural characterization of the HLA-B62 supertype."
      Roder G., Blicher T., Justesen S., Johannesen B., Kristensen O., Kastrup J., Buus S., Gajhede M.
      Acta Crystallogr. D 62:1300-1310(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.79 ANGSTROMS) OF 25-300 (ALLELE B*15:01) IN COMPLEX WITH EBV NUCLEAR ANTIGEN AND UBE2 PEPTIDES, DISULFIDE BONDS.

    Entry informationi

    Entry namei1B15_HUMAN
    AccessioniPrimary (citable) accession number: P30464
    Secondary accession number(s): B0V0B8
    , P30465, P30513, Q29633, Q29636, Q29829, Q29953, Q29982, Q95343, Q95344, Q9BD06
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 1, 1993
    Last sequence update: August 22, 2003
    Last modified: October 1, 2014
    This is version 130 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3