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Protein

HLA class I histocompatibility antigen, B-8 alpha chain

Gene

HLA-B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the presentation of foreign antigens to the immune system.

GO - Molecular functioni

  • chaperone binding Source: UniProtKB
  • peptide antigen binding Source: UniProtKB
  • TAP binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Host-virus interaction, Immunity

Enzyme and pathway databases

ReactomeiR-HSA-1236974. ER-Phagosome pathway.
R-HSA-1236977. Endosomal/Vacuolar pathway.
R-HSA-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
R-HSA-877300. Interferon gamma signaling.
R-HSA-909733. Interferon alpha/beta signaling.
R-HSA-983170. Antigen Presentation: Folding, assembly and peptide loading of class I MHC.

Names & Taxonomyi

Protein namesi
Recommended name:
HLA class I histocompatibility antigen, B-8 alpha chain
Alternative name(s):
MHC class I antigen B*8
Gene namesi
Name:HLA-B
Synonyms:HLAB
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:4932. HLA-B.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini25 – 309285ExtracellularSequence analysisAdd
BLAST
Transmembranei310 – 33324HelicalSequence analysisAdd
BLAST
Topological domaini334 – 36229CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, MHC I

Pathology & Biotechi

Organism-specific databases

MalaCardsiHLA-B.

Polymorphism and mutation databases

DMDMi231381.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424Add
BLAST
Chaini25 – 362338HLA class I histocompatibility antigen, B-8 alpha chainPRO_0000018834Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi110 – 1101N-linked (GlcNAc...)By similarity
Disulfide bondi125 ↔ 188PROSITE-ProRule annotation
Disulfide bondi227 ↔ 283PROSITE-ProRule annotation

Post-translational modificationi

Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein. This targets the protein for rapid degradation via the ubiquitin system (By similarity).By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Ubl conjugation

Proteomic databases

EPDiP30460.
PaxDbiP30460.
PeptideAtlasiP30460.
PRIDEiP30460.

PTM databases

iPTMnetiP30460.
SwissPalmiP30460.

Expressioni

Gene expression databases

CleanExiHS_HLA-B.

Interactioni

Subunit structurei

Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8 MIR1 protein (By similarity).By similarity

GO - Molecular functioni

  • chaperone binding Source: UniProtKB
  • TAP binding Source: UniProtKB

Protein-protein interaction databases

MINTiMINT-1593826.
STRINGi9606.ENSP00000399168.

Structurei

Secondary structure

1
362
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi27 – 3610Combined sources
Beta strandi41 – 433Combined sources
Beta strandi45 – 528Combined sources
Beta strandi55 – 617Combined sources
Beta strandi65 – 706Combined sources
Helixi74 – 774Combined sources
Helixi81 – 10828Combined sources
Beta strandi113 – 1153Combined sources
Beta strandi118 – 12710Combined sources
Beta strandi129 – 1313Combined sources
Beta strandi133 – 14210Combined sources
Beta strandi145 – 1506Combined sources
Beta strandi157 – 1615Combined sources
Helixi162 – 17312Combined sources
Helixi176 – 18510Combined sources
Helixi187 – 19812Combined sources
Helixi200 – 2034Combined sources
Beta strandi210 – 2178Combined sources
Beta strandi219 – 23517Combined sources
Beta strandi238 – 2436Combined sources
Helixi249 – 2513Combined sources
Beta strandi252 – 2543Combined sources
Beta strandi261 – 2633Combined sources
Beta strandi265 – 27410Combined sources
Beta strandi275 – 2773Combined sources
Helixi278 – 2803Combined sources
Beta strandi281 – 2866Combined sources
Beta strandi290 – 2923Combined sources
Beta strandi294 – 2963Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1AGBX-ray2.20A25-300[»]
1AGCX-ray2.10A25-300[»]
1AGDX-ray2.05A25-300[»]
1AGEX-ray2.30A25-300[»]
1AGFX-ray2.20A25-300[»]
1M05X-ray1.90A/C25-301[»]
1MI5X-ray2.50A25-301[»]
3FFCX-ray2.80A/F25-301[»]
3SJVX-ray3.10A/F/K/P25-301[»]
3SKMX-ray1.80A25-300[»]
3SKOX-ray1.60A25-301[»]
3SPVX-ray1.30A25-300[»]
3X13X-ray1.80A25-300[»]
3X14X-ray2.00A25-300[»]
4QRPX-ray2.90A/F25-300[»]
4QRQX-ray1.70A25-300[»]
4QRSX-ray1.40A25-300[»]
4QRTX-ray1.40A25-300[»]
4QRUX-ray1.60A25-300[»]
ProteinModelPortaliP30460.
SMRiP30460. Positions 25-300.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP30460.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini209 – 29587Ig-like C1-typeAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni25 – 11490Alpha-1Add
BLAST
Regioni115 – 20692Alpha-2Add
BLAST
Regioni207 – 29892Alpha-3Add
BLAST
Regioni299 – 30911Connecting peptideAdd
BLAST

Sequence similaritiesi

Belongs to the MHC class I family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410II5V. Eukaryota.
ENOG4111K8F. LUCA.
HOVERGENiHBG016709.
OMAiPRTHMTH.
PhylomeDBiP30460.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.30.500.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
IPR027648. MHC_I_a.
IPR001039. MHC_I_a_a1/a2.
IPR010579. MHC_I_a_C.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF00129. MHC_I. 1 hit.
PF06623. MHC_I_C. 1 hit.
[Graphical view]
PRINTSiPR01638. MHCCLASSI.
SMARTiSM00407. IGc1. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF54452. SSF54452. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P30460-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLVMAPRTVL LLLSAALALT ETWAGSHSMR YFDTAMSRPG RGEPRFISVG
60 70 80 90 100
YVDDTQFVRF DSDAASPREE PRAPWIEQEG PEYWDRNTQI FKTNTQTDRE
110 120 130 140 150
SLRNLRGYYN QSEAGSHTLQ SMYGCDVGPD GRLLRGHNQY AYDGKDYIAL
160 170 180 190 200
NEDLRSWTAA DTAAQITQRK WEAARVAEQD RAYLEGTCVE WLRRYLENGK
210 220 230 240 250
DTLERADPPK THVTHHPISD HEATLRCWAL GFYPAEITLT WQRDGEDQTQ
260 270 280 290 300
DTELVETRPA GDRTFQKWAA VVVPSGEEQR YTCHVQHEGL PKPLTLRWEP
310 320 330 340 350
SSQSTVPIVG IVAGLAVLAV VVIGAVVAAV MCRRKSSGGK GGSYSQAACS
360
DSAQGSDVSL TA
Length:362
Mass (Da):40,331
Last modified:April 1, 1993 - v1
Checksum:i9B2A9760021680DF
GO

Polymorphismi

The following alleles of B-8 are known: B*08:01, B*08:04, B*08:06, B*08:07 (B*NV), B*08:09 (B*HM; B*08HO), B*08:10, B*08:12, B*08:13 and B*08:14. The sequence shown is B*08:01.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti4 – 41M → T.
Corresponds to variant rs1050458 [ dbSNP | Ensembl ].
VAR_056321
Natural varianti9 – 91V → L.
Corresponds to variant rs1050462 [ dbSNP | Ensembl ].
VAR_056322
Natural varianti17 – 171L → V.
Corresponds to variant rs1131165 [ dbSNP | Ensembl ].
VAR_056323
Natural varianti48 – 481S → A.
Corresponds to variant rs713031 [ dbSNP | Ensembl ].
VAR_061392
Natural varianti48 – 481S → P.
Corresponds to variant rs713031 [ dbSNP | Ensembl ].
VAR_061393
Natural varianti48 – 481S → T.
Corresponds to variant rs713031 [ dbSNP | Ensembl ].
VAR_061394
Natural varianti65 – 651A → T.Combined sources
Corresponds to variant rs1050529 [ dbSNP | Ensembl ].
VAR_056324
Natural varianti87 – 871N → D in allele B*08:10.
Corresponds to variant rs1050570 [ dbSNP | Ensembl ].
VAR_016502
Natural varianti87 – 871N → K.
Corresponds to variant rs1065386 [ dbSNP | Ensembl ].
VAR_059474
Natural varianti91 – 911F → S in allele B*08:04.
Corresponds to variant rs1071816 [ dbSNP | Ensembl ].
VAR_016503
Natural varianti97 – 971T → A.
Corresponds to variant rs1050393 [ dbSNP | Ensembl ].
VAR_056325
Natural varianti98 – 981D → Y.
Corresponds to variant rs1131215 [ dbSNP | Ensembl ].
VAR_059475
Natural varianti101 – 1011S → N in allele B*08:06.
Corresponds to variant rs1050388 [ dbSNP | Ensembl ].
VAR_016504
Natural varianti119 – 1191L → W in allele B*08:09.
VAR_016505
Natural varianti121 – 1211S → R in allele B*08:12.
Corresponds to variant rs1140412 [ dbSNP | Ensembl ].
VAR_016506
Natural varianti121 – 1211S → T in allele B*08:09.
Corresponds to variant rs1071652 [ dbSNP | Ensembl ].
VAR_016507
Natural varianti137 – 1382HN → YH in allele B*08:14.
VAR_016519
Natural varianti137 – 1371H → Y.
Corresponds to variant rs1050379 [ dbSNP | Ensembl ].
VAR_056326
Natural varianti138 – 1381N → D in allele B*08:07. Combined sources
Corresponds to variant rs709055 [ dbSNP | Ensembl ].
VAR_016508
Natural varianti140 – 1401Y → D in allele B*08:14.
Corresponds to variant rs9266150 [ dbSNP | Ensembl ].
VAR_016520
Natural varianti155 – 1551R → S.Combined sources
Corresponds to variant rs1050654 [ dbSNP | Ensembl ].
VAR_056327
Natural varianti176 – 1761V → E in allele B*08:06.
Corresponds to variant rs151341293 [ dbSNP | Ensembl ].
VAR_016509
Natural varianti180 – 1801D → L in allele B*08:13; requires 2 nucleotide substitutions.
VAR_016510
Natural varianti180 – 1801D → R in allele B*08:06; requires 2 nucleotide substitutions.
VAR_016511
Natural varianti306 – 3061V → I.
Corresponds to variant rs1131500 [ dbSNP | Ensembl ].
VAR_056328
Natural varianti329 – 3291A → T.
Corresponds to variant rs1051488 [ dbSNP | Ensembl ].
VAR_056329
Natural varianti349 – 3491C → S.
Corresponds to variant rs2308655 [ dbSNP | Ensembl ].
VAR_061395
Natural varianti349 – 3491C → Y.
Corresponds to variant rs2308655 [ dbSNP | Ensembl ].
VAR_061396

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M24036 Genomic DNA. Translation: AAA52662.1.
AJ295294 Genomic DNA. Translation: CAC18876.1.
BA000025 Genomic DNA. Translation: BAB63309.1.
AH003648 Genomic DNA. Translation: AAB07726.1.
U74386 mRNA. Translation: AAB41720.1.
AF056483 Genomic DNA. Translation: AAC14124.2.
AF105226 Genomic DNA. Translation: AAD05244.1.
AH007717 Genomic DNA. Translation: AAD31431.1.
AJ131853 Genomic DNA. Translation: CAA10522.1.
AH007613 Genomic DNA. Translation: AAD28165.1.
AH009151 Genomic DNA. Translation: AAF36681.1.
AH009590 Genomic DNA. Translation: AAF81604.1.
AH009937 Genomic DNA. Translation: AAG27470.1.
AH010664 Genomic DNA. Translation: AAK38401.1.
AJ133101, AJ133102 Genomic DNA. Translation: CAB38945.1.
PIRiI84431.
RefSeqiXP_011545540.1. XM_011547238.1.
UniGeneiHs.130838.
Hs.654404.
Hs.77961.

Genome annotation databases

EnsembliENST00000425848; ENSP00000400842; ENSG00000223532.
GeneIDi3106.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M24036 Genomic DNA. Translation: AAA52662.1.
AJ295294 Genomic DNA. Translation: CAC18876.1.
BA000025 Genomic DNA. Translation: BAB63309.1.
AH003648 Genomic DNA. Translation: AAB07726.1.
U74386 mRNA. Translation: AAB41720.1.
AF056483 Genomic DNA. Translation: AAC14124.2.
AF105226 Genomic DNA. Translation: AAD05244.1.
AH007717 Genomic DNA. Translation: AAD31431.1.
AJ131853 Genomic DNA. Translation: CAA10522.1.
AH007613 Genomic DNA. Translation: AAD28165.1.
AH009151 Genomic DNA. Translation: AAF36681.1.
AH009590 Genomic DNA. Translation: AAF81604.1.
AH009937 Genomic DNA. Translation: AAG27470.1.
AH010664 Genomic DNA. Translation: AAK38401.1.
AJ133101, AJ133102 Genomic DNA. Translation: CAB38945.1.
PIRiI84431.
RefSeqiXP_011545540.1. XM_011547238.1.
UniGeneiHs.130838.
Hs.654404.
Hs.77961.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1AGBX-ray2.20A25-300[»]
1AGCX-ray2.10A25-300[»]
1AGDX-ray2.05A25-300[»]
1AGEX-ray2.30A25-300[»]
1AGFX-ray2.20A25-300[»]
1M05X-ray1.90A/C25-301[»]
1MI5X-ray2.50A25-301[»]
3FFCX-ray2.80A/F25-301[»]
3SJVX-ray3.10A/F/K/P25-301[»]
3SKMX-ray1.80A25-300[»]
3SKOX-ray1.60A25-301[»]
3SPVX-ray1.30A25-300[»]
3X13X-ray1.80A25-300[»]
3X14X-ray2.00A25-300[»]
4QRPX-ray2.90A/F25-300[»]
4QRQX-ray1.70A25-300[»]
4QRSX-ray1.40A25-300[»]
4QRTX-ray1.40A25-300[»]
4QRUX-ray1.60A25-300[»]
ProteinModelPortaliP30460.
SMRiP30460. Positions 25-300.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-1593826.
STRINGi9606.ENSP00000399168.

PTM databases

iPTMnetiP30460.
SwissPalmiP30460.

Polymorphism and mutation databases

DMDMi231381.

Proteomic databases

EPDiP30460.
PaxDbiP30460.
PeptideAtlasiP30460.
PRIDEiP30460.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000425848; ENSP00000400842; ENSG00000223532.
GeneIDi3106.

Organism-specific databases

CTDi3106.
GeneCardsiHLA-B.
HGNCiHGNC:4932. HLA-B.
MalaCardsiHLA-B.
MIMi142830. gene.
neXtProtiNX_P30460.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410II5V. Eukaryota.
ENOG4111K8F. LUCA.
HOVERGENiHBG016709.
OMAiPRTHMTH.
PhylomeDBiP30460.

Enzyme and pathway databases

ReactomeiR-HSA-1236974. ER-Phagosome pathway.
R-HSA-1236977. Endosomal/Vacuolar pathway.
R-HSA-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
R-HSA-877300. Interferon gamma signaling.
R-HSA-909733. Interferon alpha/beta signaling.
R-HSA-983170. Antigen Presentation: Folding, assembly and peptide loading of class I MHC.

Miscellaneous databases

ChiTaRSiHLA-B. human.
EvolutionaryTraceiP30460.
GenomeRNAii3106.
SOURCEiSearch...

Gene expression databases

CleanExiHS_HLA-B.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.30.500.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
IPR027648. MHC_I_a.
IPR001039. MHC_I_a_a1/a2.
IPR010579. MHC_I_a_C.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF00129. MHC_I. 1 hit.
PF06623. MHC_I_C. 1 hit.
[Graphical view]
PRINTSiPR01638. MHCCLASSI.
SMARTiSM00407. IGc1. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF54452. SSF54452. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Diversity and diversification of HLA-A,B,C alleles."
    Parham P., Lawlor D.A., Lomen C.E., Ennis P.D.
    J. Immunol. 142:3937-3950(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE B*08:01).
  2. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE B*08:01).
    Tissue: Blood.
  3. "Homo sapiens 2,229,817bp genomic DNA of 6p21.3 HLA class I region."
    Shiina S., Tamiya G., Oka A., Inoko H.
    Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (ALLELE B*08:01).
  4. "Characterization of a novel HLA-B allele, B*0804, in a Norwegian family."
    Hoyer R.J., Bratlie A., Schreuder G.M., Hurley C.K.
    Tissue Antigens 50:308-310(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 26-206 (ALLELE B*08:04).
  5. "Identification of a new HLA-B*08 variant, B*08NEW."
    Eberle M., Lorentzen D., Iwanaga K.K., Watkins D.I.
    Submitted (OCT-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 33-257 (ALLELE B*08:04).
  6. "New HLA-B locus allele."
    Marcos C.Y., Lazaro A.M., Noreen H., Stastny P.
    Submitted (MAY-2010) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 26-206 (ALLELE B*08:07).
  7. "Routine HLA-B genotyping with PCR-sequence-specific oligonucleotides (PCR-SSO) detects eight new alleles: B*0807, B*0809, B*1551, B*3529, B*3532, B*4025, B*5304 and B*5508."
    Kennedy C.T., Dodd R., Le T., Wallace R., Ng G., Greville W.D., Kennedy A., Taverniti A., Moses J.H., Clow N., Watson N., Dunckley H.
    Tissue Antigens 55:266-270(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 26-206 (ALLELES B*08:07 AND B*08:09).
  8. "Identification of the novel allele HLA-B*0809 in a Caucasian individual: estimation of allogeneic potential between B*08 variants."
    Elsner H.-A., Blasczyk R.
    Tissue Antigens 55:74-77(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 116-206 (ALLELE B*08:09).
  9. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 26-206 (ALLELES B*08:09; B*08:12; B*08:13 AND B*08:14).
  10. "A new B*08 variant allele."
    Day S.
    Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 26-206 (ALLELE B*08:10).
  11. Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF 25-300.
  12. Cited for: VARIANT [LARGE SCALE ANALYSIS] ASP-138, VARIANT [LARGE SCALE ANALYSIS] THR-65, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  13. Cited for: VARIANT [LARGE SCALE ANALYSIS] SER-155, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry namei1B08_HUMAN
AccessioniPrimary (citable) accession number: P30460
Secondary accession number(s): O62901
, O95730, O98140, P79542, Q95369, Q95J00, Q9GJ20, Q9MY78, Q9MYF4, Q9TQH6, Q9TQM2, Q9UQT0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: July 6, 2016
This is version 164 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.