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Protein

HLA class I histocompatibility antigen, B-8 alpha chain

Gene

HLA-B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in the presentation of foreign antigens to the immune system.

GO - Molecular functioni

  • chaperone binding Source: UniProtKB
  • peptide antigen binding Source: UniProtKB
  • TAP binding Source: UniProtKB

GO - Biological processi

Keywordsi

Biological processHost-virus interaction, Immunity

Enzyme and pathway databases

ReactomeiR-HSA-1236974 ER-Phagosome pathway
R-HSA-1236977 Endosomal/Vacuolar pathway
R-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
R-HSA-877300 Interferon gamma signaling
R-HSA-909733 Interferon alpha/beta signaling
R-HSA-983170 Antigen Presentation: Folding, assembly and peptide loading of class I MHC

Names & Taxonomyi

Protein namesi
Recommended name:
HLA class I histocompatibility antigen, B-8 alpha chain
Alternative name(s):
MHC class I antigen B*8
Gene namesi
Name:HLA-B
Synonyms:HLAB
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:4932 HLA-B
MIMi142830 gene
neXtProtiNX_P30460

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini25 – 309ExtracellularSequence analysisAdd BLAST285
Transmembranei310 – 333HelicalSequence analysisAdd BLAST24
Topological domaini334 – 362CytoplasmicSequence analysisAdd BLAST29

Keywords - Cellular componenti

Membrane, MHC I

Pathology & Biotechi

Organism-specific databases

DisGeNETi3106
MalaCardsiHLA-B

Polymorphism and mutation databases

DMDMi231381

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Add BLAST24
ChainiPRO_000001883425 – 362HLA class I histocompatibility antigen, B-8 alpha chainAdd BLAST338

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi110N-linked (GlcNAc...) asparagineBy similarity1
Disulfide bondi125 ↔ 188PROSITE-ProRule annotation
Disulfide bondi227 ↔ 283PROSITE-ProRule annotation

Post-translational modificationi

Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein. This targets the protein for rapid degradation via the ubiquitin system (By similarity).By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Ubl conjugation

Proteomic databases

PeptideAtlasiP30460
PRIDEiP30460

PTM databases

iPTMnetiP30460
SwissPalmiP30460

Expressioni

Gene expression databases

CleanExiHS_HLA-B

Interactioni

Subunit structurei

Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8 MIR1 protein (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
TAPBPLQ9BX593EBI-1046513,EBI-12017416

GO - Molecular functioni

  • chaperone binding Source: UniProtKB
  • TAP binding Source: UniProtKB

Protein-protein interaction databases

IntActiP30460, 6 interactors

Structurei

Secondary structure

1362
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi27 – 36Combined sources10
Beta strandi41 – 43Combined sources3
Beta strandi45 – 52Combined sources8
Beta strandi55 – 61Combined sources7
Beta strandi65 – 70Combined sources6
Helixi74 – 77Combined sources4
Helixi81 – 108Combined sources28
Beta strandi113 – 115Combined sources3
Beta strandi118 – 127Combined sources10
Beta strandi129 – 131Combined sources3
Beta strandi133 – 142Combined sources10
Beta strandi145 – 150Combined sources6
Beta strandi157 – 161Combined sources5
Helixi162 – 173Combined sources12
Helixi176 – 185Combined sources10
Helixi187 – 198Combined sources12
Helixi200 – 203Combined sources4
Beta strandi210 – 217Combined sources8
Beta strandi219 – 235Combined sources17
Beta strandi238 – 243Combined sources6
Helixi249 – 251Combined sources3
Beta strandi252 – 254Combined sources3
Beta strandi261 – 263Combined sources3
Beta strandi265 – 274Combined sources10
Beta strandi275 – 277Combined sources3
Helixi278 – 280Combined sources3
Beta strandi281 – 286Combined sources6
Beta strandi290 – 292Combined sources3
Beta strandi294 – 296Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1AGBX-ray2.20A25-300[»]
1AGCX-ray2.10A25-300[»]
1AGDX-ray2.05A25-300[»]
1AGEX-ray2.30A25-300[»]
1AGFX-ray2.20A25-300[»]
1M05X-ray1.90A/C25-301[»]
1MI5X-ray2.50A25-301[»]
3FFCX-ray2.80A/F25-301[»]
3SJVX-ray3.10A/F/K/P25-301[»]
3SKMX-ray1.80A25-300[»]
3SKOX-ray1.60A25-301[»]
3SPVX-ray1.30A25-300[»]
3X13X-ray1.80A25-300[»]
3X14X-ray2.00A25-300[»]
4QRPX-ray2.90A/F25-300[»]
4QRQX-ray1.70A25-300[»]
4QRSX-ray1.40A25-300[»]
4QRTX-ray1.40A25-300[»]
4QRUX-ray1.60A25-300[»]
ProteinModelPortaliP30460
SMRiP30460
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP30460

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini209 – 295Ig-like C1-typeAdd BLAST87

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni25 – 114Alpha-1Add BLAST90
Regioni115 – 206Alpha-2Add BLAST92
Regioni207 – 298Alpha-3Add BLAST92
Regioni299 – 309Connecting peptideAdd BLAST11

Sequence similaritiesi

Belongs to the MHC class I family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410II5V Eukaryota
ENOG4111K8F LUCA
HOVERGENiHBG016709
OrthoDBiEOG091G09OH
PhylomeDBiP30460

Family and domain databases

Gene3Di2.60.40.10, 1 hit
3.30.500.10, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003006 Ig/MHC_CS
IPR003597 Ig_C1-set
IPR011161 MHC_I-like_Ag-recog
IPR037055 MHC_I-like_Ag-recog_sf
IPR011162 MHC_I/II-like_Ag-recog
IPR001039 MHC_I_a_a1/a2
IPR010579 MHC_I_a_C
PfamiView protein in Pfam
PF07654 C1-set, 1 hit
PF00129 MHC_I, 1 hit
PF06623 MHC_I_C, 1 hit
PRINTSiPR01638 MHCCLASSI
SMARTiView protein in SMART
SM00407 IGc1, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
SSF54452 SSF54452, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
PS00290 IG_MHC, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P30460-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLVMAPRTVL LLLSAALALT ETWAGSHSMR YFDTAMSRPG RGEPRFISVG
60 70 80 90 100
YVDDTQFVRF DSDAASPREE PRAPWIEQEG PEYWDRNTQI FKTNTQTDRE
110 120 130 140 150
SLRNLRGYYN QSEAGSHTLQ SMYGCDVGPD GRLLRGHNQY AYDGKDYIAL
160 170 180 190 200
NEDLRSWTAA DTAAQITQRK WEAARVAEQD RAYLEGTCVE WLRRYLENGK
210 220 230 240 250
DTLERADPPK THVTHHPISD HEATLRCWAL GFYPAEITLT WQRDGEDQTQ
260 270 280 290 300
DTELVETRPA GDRTFQKWAA VVVPSGEEQR YTCHVQHEGL PKPLTLRWEP
310 320 330 340 350
SSQSTVPIVG IVAGLAVLAV VVIGAVVAAV MCRRKSSGGK GGSYSQAACS
360
DSAQGSDVSL TA
Length:362
Mass (Da):40,331
Last modified:April 1, 1993 - v1
Checksum:i9B2A9760021680DF
GO

Polymorphismi

The following alleles of B-8 are known: B*08:01, B*08:04, B*08:06, B*08:07 (B*NV), B*08:09 (B*HM; B*08HO), B*08:10, B*08:12, B*08:13 and B*08:14. The sequence shown is B*08:01.

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0563214M → T. Corresponds to variant dbSNP:rs1050458Ensembl.1
Natural variantiVAR_0563229V → L. Corresponds to variant dbSNP:rs1050462Ensembl.1
Natural variantiVAR_05632317L → V. Corresponds to variant dbSNP:rs1131165Ensembl.1
Natural variantiVAR_06139248S → A. Corresponds to variant dbSNP:rs713031Ensembl.1
Natural variantiVAR_06139348S → P. Corresponds to variant dbSNP:rs713031Ensembl.1
Natural variantiVAR_06139448S → T. Corresponds to variant dbSNP:rs713031Ensembl.1
Natural variantiVAR_05632465A → TCombined sourcesCorresponds to variant dbSNP:rs1050529Ensembl.1
Natural variantiVAR_01650287N → D in allele B*08:10. Corresponds to variant dbSNP:rs1050570Ensembl.1
Natural variantiVAR_05947487N → K. Corresponds to variant dbSNP:rs1065386Ensembl.1
Natural variantiVAR_01650391F → S in allele B*08:04. Corresponds to variant dbSNP:rs1071816Ensembl.1
Natural variantiVAR_05632597T → A. Corresponds to variant dbSNP:rs1050393Ensembl.1
Natural variantiVAR_05947598D → Y. Corresponds to variant dbSNP:rs1131215Ensembl.1
Natural variantiVAR_016504101S → N in allele B*08:06. Corresponds to variant dbSNP:rs1050388Ensembl.1
Natural variantiVAR_016505119L → W in allele B*08:09. 1
Natural variantiVAR_016506121S → R in allele B*08:12. Corresponds to variant dbSNP:rs1140412Ensembl.1
Natural variantiVAR_016507121S → T in allele B*08:09. Corresponds to variant dbSNP:rs1071652Ensembl.1
Natural variantiVAR_016519137 – 138HN → YH in allele B*08:14. 2
Natural variantiVAR_056326137H → Y. Corresponds to variant dbSNP:rs1050379Ensembl.1
Natural variantiVAR_016508138N → D in allele B*08:07. Combined sourcesCorresponds to variant dbSNP:rs709055Ensembl.1
Natural variantiVAR_016520140Y → D in allele B*08:14. Corresponds to variant dbSNP:rs9266150Ensembl.1
Natural variantiVAR_056327155R → SCombined sourcesCorresponds to variant dbSNP:rs1050654Ensembl.1
Natural variantiVAR_016509176V → E in allele B*08:06. Corresponds to variant dbSNP:rs151341293Ensembl.1
Natural variantiVAR_016510180D → L in allele B*08:13; requires 2 nucleotide substitutions. 1
Natural variantiVAR_016511180D → R in allele B*08:06; requires 2 nucleotide substitutions. Corresponds to variant dbSNP:rs376871308Ensembl.1
Natural variantiVAR_056328306V → I. Corresponds to variant dbSNP:rs1131500Ensembl.1
Natural variantiVAR_056329329A → T. Corresponds to variant dbSNP:rs1051488Ensembl.1
Natural variantiVAR_061395349C → S. Corresponds to variant dbSNP:rs2308655Ensembl.1
Natural variantiVAR_061396349C → Y. Corresponds to variant dbSNP:rs2308655Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M24036 Genomic DNA Translation: AAA52662.1
AJ295294 Genomic DNA Translation: CAC18876.1
BA000025 Genomic DNA Translation: BAB63309.1
AH003648 Genomic DNA Translation: AAB07726.1
U74386 mRNA Translation: AAB41720.1
AF056483 Genomic DNA Translation: AAC14124.2
AF105226 Genomic DNA Translation: AAD05244.1
AH007717 Genomic DNA Translation: AAD31431.1
AJ131853 Genomic DNA Translation: CAA10522.1
AH007613 Genomic DNA Translation: AAD28165.1
AH009151 Genomic DNA Translation: AAF36681.1
AH009590 Genomic DNA Translation: AAF81604.1
AH009937 Genomic DNA Translation: AAG27470.1
AH010664 Genomic DNA Translation: AAK38401.1
AJ133101, AJ133102 Genomic DNA Translation: CAB38945.1
PIRiI84431
UniGeneiHs.130838
Hs.654404
Hs.726974
Hs.77961

Genome annotation databases

EnsembliENST00000425848; ENSP00000400842; ENSG00000223532

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry namei1B08_HUMAN
AccessioniPrimary (citable) accession number: P30460
Secondary accession number(s): O62901
, O95730, O98140, P79542, Q95369, Q95J00, Q9GJ20, Q9MY78, Q9MYF4, Q9TQH6, Q9TQM2, Q9UQT0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: May 23, 2018
This is version 180 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

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