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Protein

HLA class I histocompatibility antigen, A-26 alpha chain

Gene

HLA-A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the presentation of foreign antigens to the immune system.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Host-virus interaction, Immunity

Enzyme and pathway databases

ReactomeiR-HSA-1236974. ER-Phagosome pathway.
R-HSA-1236977. Endosomal/Vacuolar pathway.
R-HSA-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
R-HSA-877300. Interferon gamma signaling.
R-HSA-909733. Interferon alpha/beta signaling.
R-HSA-983170. Antigen Presentation: Folding, assembly and peptide loading of class I MHC.

Names & Taxonomyi

Protein namesi
Recommended name:
HLA class I histocompatibility antigen, A-26 alpha chain
Alternative name(s):
MHC class I antigen A*26
Gene namesi
Name:HLA-A
Synonyms:HLAA
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:4931. HLA-A.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini25 – 308284ExtracellularSequence analysisAdd
BLAST
Transmembranei309 – 33224HelicalSequence analysisAdd
BLAST
Topological domaini333 – 36533CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, MHC I

Pathology & Biotechi

Organism-specific databases

MalaCardsiHLA-A.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424Add
BLAST
Chaini25 – 365341HLA class I histocompatibility antigen, A-26 alpha chainPRO_0000018820Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi110 – 1101N-linked (GlcNAc...)By similarity
Disulfide bondi125 ↔ 188PROSITE-ProRule annotation
Disulfide bondi227 ↔ 283PROSITE-ProRule annotation
Modified residuei343 – 3431PhosphoserineCombined sources
Modified residuei344 – 3441PhosphotyrosineCombined sources
Modified residuei345 – 3451PhosphoserineCombined sources
Modified residuei349 – 3491PhosphoserineCombined sources
Modified residuei350 – 3501PhosphoserineBy similarity
Modified residuei352 – 3521PhosphoserineCombined sources
Modified residuei356 – 3561PhosphoserineCombined sources
Modified residuei359 – 3591PhosphoserineCombined sources

Post-translational modificationi

Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein. This targets the protein for rapid degradation via the ubiquitin system (By similarity).By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP30450.
PRIDEiP30450.

PTM databases

iPTMnetiP30450.

Expressioni

Gene expression databases

CleanExiHS_HLA-A.

Interactioni

Subunit structurei

Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8 MIR1 protein (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi109350. 102 interactions.

Structurei

3D structure databases

ProteinModelPortaliP30450.
SMRiP30450. Positions 25-294.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini209 – 29587Ig-like C1-typeAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni25 – 11490Alpha-1Add
BLAST
Regioni115 – 20692Alpha-2Add
BLAST
Regioni207 – 29892Alpha-3Add
BLAST
Regioni299 – 30810Connecting peptide

Sequence similaritiesi

Belongs to the MHC class I family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG016709.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.30.500.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
IPR027648. MHC_I_a.
IPR001039. MHC_I_a_a1/a2.
IPR010579. MHC_I_a_C.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF00129. MHC_I. 1 hit.
PF06623. MHC_I_C. 1 hit.
[Graphical view]
PRINTSiPR01638. MHCCLASSI.
SMARTiSM00407. IGc1. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF54452. SSF54452. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P30450-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVMAPRTLV LLLSGALALT QTWAGSHSMR YFYTSVSRPG RGEPRFIAVG
60 70 80 90 100
YVDDTQFVRF DSDAASQRME PRAPWIEQEG PEYWDRNTRN VKAHSQTDRA
110 120 130 140 150
NLGTLRGYYN QSEDGSHTIQ RMYGCDVGPD GRFLRGYQQD AYDGKDYIAL
160 170 180 190 200
NEDLRSWTAA DMAAQITQRK WETAHEAEQW RAYLEGRCVE WLRRYLENGK
210 220 230 240 250
ETLQRTDAPK THMTHHAVSD HEATLRCWAL SFYPAEITLT WQRDGEDQTQ
260 270 280 290 300
DTELVETRPA GDGTFQKWAS VVVPSGQEQR YTCHVQHEGL PKPLTLRWEP
310 320 330 340 350
SSQPTIPIVG IIAGLVLFGA VIAGAVVAAV MWRRKSSDRK GGSYSQAASS
360
DSAQGSDMSL TACKV
Length:365
Mass (Da):41,062
Last modified:November 1, 1995 - v2
Checksum:i44B54DD363B46EDA
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti153 – 1531D → H in AAA59655 (PubMed:2914713).Curated
Sequence conflicti160 – 1601A → G in AAA59655 (PubMed:2914713).Curated

Polymorphismi

The following alleles of A-26 are known: A*26:01, A*26:02, A*26:03, A*26:04 (A-10SA), A*26:05, A*26:07, A*26:08, A*26:12 and A*26:15. The sequence shown is that of A*26:01.Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti60 – 601F → L in allele A*26:15. 1 Publication
VAR_016341
Natural varianti86 – 872RN → GE in allele A*26:07. 2 Publications
VAR_016342
Natural varianti89 – 891R → G.
Corresponds to variant rs1059459 [ dbSNP | Ensembl ].
VAR_050321
Natural varianti90 – 901N → K in allele A*26:07. 2 Publications
VAR_016343
Natural varianti94 – 941H → Q.
Corresponds to variant rs1059463 [ dbSNP | Ensembl ].
VAR_050322
Natural varianti98 – 1014DRAN → HRVD in allele A*26:03. Combined sources2 Publications
VAR_004362
Natural varianti100 – 1001A → E in allele A*26:05. 1 Publication
VAR_016344
Natural varianti101 – 1011N → D.
Corresponds to variant rs1136688 [ dbSNP | Ensembl ].
VAR_050323
Natural varianti129 – 1291P → S.
Corresponds to variant rs1136700 [ dbSNP | Ensembl ].
VAR_050324
Natural varianti131 – 1311G → W.
Corresponds to variant rs1136702 [ dbSNP | Ensembl ].
VAR_050325
Natural varianti133 – 1331F → L.
Corresponds to variant rs1059488 [ dbSNP | Ensembl ].
VAR_050326
Natural varianti140 – 1401D → N in allele A*26:02. 2 Publications
VAR_004364
Natural varianti151 – 1511N → K.
Corresponds to variant rs1059509 [ dbSNP | Ensembl ].
VAR_050327
Natural varianti166 – 1661I → T.
Corresponds to variant rs1059516 [ dbSNP | Ensembl ].
VAR_050328
Natural varianti169 – 1691R → H.
Corresponds to variant rs1059520 [ dbSNP | Ensembl ].
VAR_050329
Natural varianti176 – 1761E → V in allele A*26:12. 2 Publications
VAR_016345
Natural varianti180 – 1801W → Q in allele A*26:08; requires 2 nucleotide substitutions. 2 Publications
VAR_016346
Natural varianti180 – 1801W → R.
Corresponds to variant rs9260155 [ dbSNP | Ensembl ].
VAR_050330
Natural varianti185 – 1851E → D.
Corresponds to variant rs1059542 [ dbSNP | Ensembl ].
VAR_050331
Natural varianti187 – 1871R → L in allele A*26:04. 1 Publication
VAR_004363
Natural varianti306 – 3061I → V.
Corresponds to variant rs1136949 [ dbSNP | Ensembl ].
VAR_014603

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U03697 mRNA. Translation: AAA03720.1.
M98453 mRNA. Translation: AAA35991.1.
D14350 mRNA. Translation: BAA03279.1.
D14351 mRNA. Translation: BAA03280.1.
D14354 mRNA. Translation: BAA03282.1.
D16843 mRNA. Translation: BAA04119.1.
D32130 mRNA. Translation: BAA06856.1.
D32131 mRNA. Translation: BAA06857.1.
D32129 mRNA. Translation: BAA06855.1.
D50068 mRNA. Translation: BAA08783.1.
L48341 Genomic DNA. Translation: AAF25960.1.
U52429 mRNA. Translation: AAB08574.1.
U45480 mRNA. Translation: AAB38491.1.
AH006114 Genomic DNA. Translation: AAC17438.1.
AH007202 Genomic DNA. Translation: AAD02210.1.
AJ291695, AJ291696 Genomic DNA. Translation: CAC27239.1.
AJ290394 mRNA. Translation: CAC27416.2.
M24095 mRNA. Translation: AAA59655.1.
PIRiA37028.
I38436.
I84487.
UniGeneiHs.181244.
Hs.713441.

Genome annotation databases

EnsembliENST00000383605; ENSP00000373100; ENSG00000206505.
ENST00000549224; ENSP00000447990; ENSG00000206505.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U03697 mRNA. Translation: AAA03720.1.
M98453 mRNA. Translation: AAA35991.1.
D14350 mRNA. Translation: BAA03279.1.
D14351 mRNA. Translation: BAA03280.1.
D14354 mRNA. Translation: BAA03282.1.
D16843 mRNA. Translation: BAA04119.1.
D32130 mRNA. Translation: BAA06856.1.
D32131 mRNA. Translation: BAA06857.1.
D32129 mRNA. Translation: BAA06855.1.
D50068 mRNA. Translation: BAA08783.1.
L48341 Genomic DNA. Translation: AAF25960.1.
U52429 mRNA. Translation: AAB08574.1.
U45480 mRNA. Translation: AAB38491.1.
AH006114 Genomic DNA. Translation: AAC17438.1.
AH007202 Genomic DNA. Translation: AAD02210.1.
AJ291695, AJ291696 Genomic DNA. Translation: CAC27239.1.
AJ290394 mRNA. Translation: CAC27416.2.
M24095 mRNA. Translation: AAA59655.1.
PIRiA37028.
I38436.
I84487.
UniGeneiHs.181244.
Hs.713441.

3D structure databases

ProteinModelPortaliP30450.
SMRiP30450. Positions 25-294.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109350. 102 interactions.

PTM databases

iPTMnetiP30450.

Proteomic databases

EPDiP30450.
PRIDEiP30450.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000383605; ENSP00000373100; ENSG00000206505.
ENST00000549224; ENSP00000447990; ENSG00000206505.

Organism-specific databases

GeneCardsiHLA-A.
HGNCiHGNC:4931. HLA-A.
MalaCardsiHLA-A.
MIMi142800. gene.
neXtProtiNX_P30450.
GenAtlasiSearch...

Phylogenomic databases

HOVERGENiHBG016709.

Enzyme and pathway databases

ReactomeiR-HSA-1236974. ER-Phagosome pathway.
R-HSA-1236977. Endosomal/Vacuolar pathway.
R-HSA-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
R-HSA-877300. Interferon gamma signaling.
R-HSA-909733. Interferon alpha/beta signaling.
R-HSA-983170. Antigen Presentation: Folding, assembly and peptide loading of class I MHC.

Miscellaneous databases

ChiTaRSiHLA-A. human.
SOURCEiSearch...

Gene expression databases

CleanExiHS_HLA-A.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.30.500.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
IPR027648. MHC_I_a.
IPR001039. MHC_I_a_a1/a2.
IPR010579. MHC_I_a_C.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF00129. MHC_I. 1 hit.
PF06623. MHC_I_C. 1 hit.
[Graphical view]
PRINTSiPR01638. MHCCLASSI.
SMARTiSM00407. IGc1. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF54452. SSF54452. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE (ALLELES A*26:01 AND A*26:02).
  2. "Nucleotide sequence of the HLA-A26 class I gene: identification of specific residues and molecular mapping of public HLA class I epitopes."
    Zinzsner H., Masset M., Bourge J.-F., Colombani J., Cohen D., Degos L., Paul P.
    Hum. Immunol. 27:155-166(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE (ALLELE A*26:01).
  3. "Sequences of four splits of HLA-A10 group. Implications for serologic cross-reactivities and their evolution."
    Ishikawa Y., Tokunaga K., Lin L., Imanishi T., Saitou S., Kashiwase K., Akaza T., Tadokoro K., Juji T.
    Hum. Immunol. 39:220-224(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELES A*26:01; A*26:02; A*26:03 AND A*26:04).
    Tissue: Blood.
  4. Miyashita H., Fujiyoshi T., Yashiki S., Kuwayama M., Fujiyama C., Sonoda S.
    Submitted (JUL-1994) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE (ALLELE A*26:01).
    Tissue: Lymphocyte.
  5. "Cloning of HLA-A26 cDNA from Japanese donors possessing 'ATL-associated HLA haplotypes'."
    Miyashita H., Fujiyoshi T., Yashiki S., Kuwayama M., Fujiyama C., Sonoda S.
    Tissue Antigens 46:398-400(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE A*26:03).
    Tissue: Lymphocyte.
  6. "A novel A26 sequence found in Japanese, and identification of four major HLA-A26 subtypes."
    Maruya E., Ishikawa Y., Lin L., Tokunaga K., Kimura A., Saitou S., Nita H., Juji T., Saji H.
    Submitted (APR-1995) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE (ALLELE A*26:05).
    Tissue: Blood.
  7. "HLA-A *2607: sequence of a novel A*26 subtype predicted by DNA typing which shares the MA2.1 epitope with A*02, B*57 and B*58."
    Arnett K.L., Moses J.H., Williams F., Marsh S.G.E., Bodmer J.G., Parham P., Middleton D.
    Tissue Antigens 47:422-425(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE A*26:07).
  8. "Nucleotide sequence for HLA-A*2608 which encodes glutamine at codon 156."
    Szmania S., Baxter-Lowe L.A.
    Tissue Antigens 48:210-212(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE A*26:08).
  9. Ellexson M.E., Hildebrand W.H.
    Submitted (JAN-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE (ALLELE A*26:08).
  10. "Diversity is demonstrated in class I HLA-A and HLA-B alleles in Cameroon, Africa: description of HLA-A*03012, *2612, *3006 and HLA-B*1403, *4016, *4703."
    Ellis J.M., Mack S.J., Leke R.F.G., Quakyi I., Johnson A.H., Hurley C.K.
    Tissue Antigens 56:291-302(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE OF 26-206 (ALLELE A*26:12).
  11. Cited for: NUCLEOTIDE SEQUENCE OF 26-206 (ALLELE A*26:12).
  12. "New HLA-A alleles detected by sequence-based typing."
    Voorter C.E., Gervais T., van den Berg-Loonene E.M.
    Submitted (NOV-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE OF 26-206 (ALLELE A*26:15).
  13. "A new variant form of a HLA A*2607 allele."
    Moine A.
    Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE OF 26-298 (ALLELE A*26:07).
  14. "Three new class I HLA alleles: structure of mRNAs and alternative mechanisms of processing."
    Cianetti L., Testa U., Scotto L., la Valle R., Simeone A., Boccoli G., Giannella G., Peschle C., Boncinelli E.
    Immunogenetics 29:80-91(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 27-365 (ALLELE A*26:01).
  15. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-343; TYR-344; SER-345; SER-349; SER-352; SER-356 AND SER-359, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  16. Cited for: VARIANT [LARGE SCALE ANALYSIS] 98-ASP--ASN-101 DELINS HIS-ARG-VAL-ASP, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  17. Cited for: VARIANT [LARGE SCALE ANALYSIS] 98-ASP--ASN-101 DELINS HIS-ARG-VAL-ASP, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry namei1A26_HUMAN
AccessioniPrimary (citable) accession number: P30450
Secondary accession number(s): O02963
, O78073, P79563, Q30208, Q31623, Q95377, Q9BD15, Q9BD19, Q9MW42, Q9TQK5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: November 1, 1995
Last modified: May 11, 2016
This is version 147 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.