P30450 (1A26_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
HLA class I histocompatibility antigen, A-26 alpha chain

Alternative name(s):
MHC class I antigen A*26

Gene names

Name:	HLA-A
Synonyms:	HLAA

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	365 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Involved in the presentation of foreign antigens to the immune system.
Subunit structure	Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8 MIR1 protein By similarity.
Subcellular location	Membrane; Single-pass type I membrane protein.
Post-translational modification	Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein. This targets the protein for rapid degradation via the ubiquitin system By similarity.
Polymorphism	The following alleles of A-26 are known: A*26:01, A*26:02, A*26:03, A*26:04 (A-10SA), A*26:05, A*26:07, A*26:08, A*26:12 and A*26:15. The sequence shown is that of A*26:01.
Sequence similarities	Belongs to the MHC class I family. Contains 1 Ig-like C1-type (immunoglobulin-like) domain.

Ontologies

Keywords
Biological process	Host-virus interaction Immunity
Cellular component	MHC I Membrane
Coding sequence diversity	Polymorphism
Domain	Signal Transmembrane Transmembrane helix
PTM	Disulfide bond Glycoprotein Ubl conjugation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	antigen processing and presentation of peptide antigen via MHC class I Inferred from electronic annotation. Source: UniProtKB-KW immune response Inferred from electronic annotation. Source: InterPro interspecies interaction between organisms Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	MHC class I protein complex Inferred from electronic annotation. Source: UniProtKB-KW integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 24	24
	Chain	25 – 365	341	HLA class I histocompatibility antigen, A-26 alpha chain		PRO_0000018820
Regions
	Topological domain	25 – 308	284	Extracellular Potential
	Transmembrane	309 – 332	24	Helical; Potential
	Topological domain	333 – 365	33	Cytoplasmic Potential
	Domain	209 – 295	87	Ig-like C1-type
	Region	25 – 114	90	Alpha-1
	Region	115 – 206	92	Alpha-2
	Region	207 – 298	92	Alpha-3
	Region	299 – 308	10	Connecting peptide
Amino acid modifications
	Glycosylation	110	1	N-linked (GlcNAc...) By similarity
	Disulfide bond	125 ↔ 188		By similarity
	Disulfide bond	227 ↔ 283		By similarity
Natural variations
	Natural variant	60	1	F → L in allele A*26:15.		VAR_016341
	Natural variant	86 – 87	2	RN → GE in allele A*26:07.		VAR_016342
	Natural variant	89	1	R → G. Corresponds to variant rs1059459 [ dbSNP | Ensembl ].		VAR_050321
	Natural variant	90	1	N → K in allele A*26:07.		VAR_016343
	Natural variant	94	1	H → Q. Corresponds to variant rs1059463 [ dbSNP | Ensembl ].		VAR_050322
	Natural variant	98 – 101	4	DRAN → HRVD in allele A*26:03.		VAR_004362
	Natural variant	100	1	A → E in allele A*26:05.		VAR_016344
	Natural variant	101	1	N → D. Corresponds to variant rs1136688 [ dbSNP | Ensembl ].		VAR_050323
	Natural variant	129	1	P → S. Corresponds to variant rs1136700 [ dbSNP | Ensembl ].		VAR_050324
	Natural variant	131	1	G → W. Corresponds to variant rs1136702 [ dbSNP | Ensembl ].		VAR_050325
	Natural variant	133	1	F → L. Corresponds to variant rs1059488 [ dbSNP | Ensembl ].		VAR_050326
	Natural variant	140	1	D → N in allele A*26:02.		VAR_004364
	Natural variant	151	1	N → K. Corresponds to variant rs1059509 [ dbSNP | Ensembl ].		VAR_050327
	Natural variant	166	1	I → T. Corresponds to variant rs1059516 [ dbSNP | Ensembl ].		VAR_050328
	Natural variant	169	1	R → H. Corresponds to variant rs1059520 [ dbSNP | Ensembl ].		VAR_050329
	Natural variant	176	1	E → V in allele A*26:12.		VAR_016345
	Natural variant	180	1	W → Q in allele A*26:08; requires 2 nucleotide substitutions.		VAR_016346
	Natural variant	180	1	W → R. Corresponds to variant rs9260155 [ dbSNP | Ensembl ].		VAR_050330
	Natural variant	185	1	E → D. Corresponds to variant rs1059542 [ dbSNP | Ensembl ].		VAR_050331
	Natural variant	187	1	R → L in allele A*26:04.		VAR_004363
	Natural variant	306	1	I → V. Corresponds to variant rs1136949 [ dbSNP | Ensembl ].		VAR_014603
Experimental info
	Sequence conflict	153	1	D → H in AAA59655. Ref.14
	Sequence conflict	160	1	A → G in AAA59655. Ref.14

Sequences

	Sequence		Length	Mass (Da)
	P30450 [UniParc]. Last modified November 1, 1995. Version 2. Checksum: 44B54DD363B46EDA	FASTA	365	41,062
	10 20 30 40 50 60 MAVMAPRTLV LLLSGALALT QTWAGSHSMR YFYTSVSRPG RGEPRFIAVG YVDDTQFVRF 70 80 90 100 110 120 DSDAASQRME PRAPWIEQEG PEYWDRNTRN VKAHSQTDRA NLGTLRGYYN QSEDGSHTIQ 130 140 150 160 170 180 RMYGCDVGPD GRFLRGYQQD AYDGKDYIAL NEDLRSWTAA DMAAQITQRK WETAHEAEQW 190 200 210 220 230 240 RAYLEGRCVE WLRRYLENGK ETLQRTDAPK THMTHHAVSD HEATLRCWAL SFYPAEITLT 250 260 270 280 290 300 WQRDGEDQTQ DTELVETRPA GDGTFQKWAS VVVPSGQEQR YTCHVQHEGL PKPLTLRWEP 310 320 330 340 350 360 SSQPTIPIVG IIAGLVLFGA VIAGAVVAAV MWRRKSSDRK GGSYSQAASS DSAQGSDMSL TACKV

References

[1]	"Structural diversity in the HLA-A10 family of alleles: correlations with serology." Madrigal J.A., Hildebrand W.H., Belich M.P., Benjamin R.J., Little A.-M., Zemmour J., Ennis P.D., Ward F.E., Petzl-Erler M.L., du Toit E.D., Parham P. Tissue Antigens 41:72-80(1993) [PubMed: 8475492] [Abstract] Cited for: NUCLEOTIDE SEQUENCE (ALLELES A*26:01 AND A*26:02).
[2]	"Nucleotide sequence of the HLA-A26 class I gene: identification of specific residues and molecular mapping of public HLA class I epitopes." Zinzsner H., Masset M., Bourge J.-F., Colombani J., Cohen D., Degos L., Paul P. Hum. Immunol. 27:155-166(1990) [PubMed: 1692821] [Abstract] Cited for: NUCLEOTIDE SEQUENCE (ALLELE A*26:01).
[3]	"Sequences of four splits of HLA-A10 group. Implications for serologic cross-reactivities and their evolution." Ishikawa Y., Tokunaga K., Lin L., Imanishi T., Saitou S., Kashiwase K., Akaza T., Tadokoro K., Juji T. Hum. Immunol. 39:220-224(1994) [PubMed: 8026990] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELES A*26:01; A*26:02; A*26:03 AND A*26:04). Tissue: Blood.
[4]	Miyashita H., Fujiyoshi T., Yashiki S., Kuwayama M., Fujiyama C., Sonoda S. Submitted (JUL-1994) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE (ALLELE A*26:01). Tissue: Lymphocyte.
[5]	"Cloning of HLA-A26 cDNA from Japanese donors possessing 'ATL-associated HLA haplotypes'." Miyashita H., Fujiyoshi T., Yashiki S., Kuwayama M., Fujiyama C., Sonoda S. Tissue Antigens 46:398-400(1995) [PubMed: 8838351] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE A*26:03). Tissue: Lymphocyte.
[6]	"A novel A26 sequence found in Japanese, and identification of four major HLA-A26 subtypes." Maruya E., Ishikawa Y., Lin L., Tokunaga K., Kimura A., Saitou S., Nita H., Juji T., Saji H. Submitted (APR-1995) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE (ALLELE A*26:05). Tissue: Blood.
[7]	"HLA-A *2607: sequence of a novel A*26 subtype predicted by DNA typing which shares the MA2.1 epitope with A*02, B*57 and B*58." Arnett K.L., Moses J.H., Williams F., Marsh S.G.E., Bodmer J.G., Parham P., Middleton D. Tissue Antigens 47:422-425(1996) [PubMed: 8795143] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE A*26:07).
[8]	"Nucleotide sequence for HLA-A*2608 which encodes glutamine at codon 156." Szmania S., Baxter-Lowe L.A. Tissue Antigens 48:210-212(1996) [PubMed: 8896181] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE A*26:08).
[9]	Ellexson M.E., Hildebrand W.H. Submitted (JAN-1996) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE (ALLELE A*26:08).
[10]	"Diversity is demonstrated in class I HLA-A and HLA-B alleles in Cameroon, Africa: description of HLA-A*03012, *2612, *3006 and HLA-B*1403, *4016, *4703." Ellis J.M., Mack S.J., Leke R.F.G., Quakyi I., Johnson A.H., Hurley C.K. Tissue Antigens 56:291-302(2000) [PubMed: 11098929] [Abstract] Cited for: NUCLEOTIDE SEQUENCE OF 26-206 (ALLELE A*26:12).
[11]	"Non-conservative substitutions distinguish previously uncharacterized HLA-A molecules." Hickman H.D., Cavett J.W., Ellexson-Turner M.E., Sparkman J.N., Bennett T.T., Turner S., Sidebottom D.A., Trachtenberg E.A., Confer D.L., Hildebrand W.H. Tissue Antigens 57:95-102(2001) [PubMed: 11260503] [Abstract] Cited for: NUCLEOTIDE SEQUENCE OF 26-206 (ALLELE A*26:12).
[12]	"New HLA-A alleles detected by sequence-based typing." Voorter C.E., Gervais T., van den Berg-Loonene E.M. Submitted (NOV-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE OF 26-206 (ALLELE A*26:15).
[13]	"A new variant form of a HLA A*2607 allele." Moine A. Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE OF 26-298 (ALLELE A*26:07).
[14]	"Three new class I HLA alleles: structure of mRNAs and alternative mechanisms of processing." Cianetti L., Testa U., Scotto L., la Valle R., Simeone A., Boccoli G., Giannella G., Peschle C., Boncinelli E. Immunogenetics 29:80-91(1989) [PubMed: 2914713] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 27-365 (ALLELE A*26:01).
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U03697 mRNA. Translation: AAA03720.1. M98453 mRNA. Translation: AAA35991.1. D14350 mRNA. Translation: BAA03279.1. D14351 mRNA. Translation: BAA03280.1. D14354 mRNA. Translation: BAA03282.1. D16843 mRNA. Translation: BAA04119.1. D32130 mRNA. Translation: BAA06856.1. D32131 mRNA. Translation: BAA06857.1. D32129 mRNA. Translation: BAA06855.1. D50068 mRNA. Translation: BAA08783.1. L48341 Genomic DNA. Translation: AAF25960.1. U52429 mRNA. Translation: AAB08574.1. U45480 mRNA. Translation: AAB38491.1. AF065487, AF065486 Genomic DNA. Translation: AAC17438.1. AF042187, AF042186 Genomic DNA. Translation: AAD02210.1. AJ291695, AJ291696 Genomic DNA. Translation: CAC27239.1. AJ290394 mRNA. Translation: CAC27416.2. M24095 mRNA. Translation: AAA59655.1.
IPI	IPI00743359.
PIR	A37028. I38436. I84487.
UniGene	Hs.181244. Hs.713441.
3D structure databases
ProteinModelPortal	P30450.
SMR	P30450. Positions 25-299.
ModBase	Search...
Protein-protein interaction databases
STRING	P30450.
Polymorphism databases
DMDM	1168209.
Proteomic databases
PRIDE	P30450.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000383605; ENSP00000373100; ENSG00000206505. ENST00000383617; ENSP00000373112; ENSG00000206505.
Organism-specific databases
GeneCards	GC06P029921. GC06Pn29898.
H-InvDB	HIX0033011.
HGNC	HGNC:4931. HLA-A.
MIM	142800. gene.
neXtProt	NX_P30450.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	HBG016709.
Gene expression databases
CleanEx	HS_HLA-A.
Genevestigator	P30450.
GermOnline	ENSG00000204632. Homo sapiens.
Family and domain databases
InterPro	IPR007110. Ig-like. IPR013783. Ig-like_fold. IPR003006. Ig/MHC_CS. IPR003597. Ig_C1-set. IPR011161. MHC_I-like_Ag-recog. IPR011162. MHC_I/II-like_Ag-recog. IPR001039. MHC_I_a_a1/a2. IPR010579. MHC_I_a_C. [Graphical view]
Gene3D	G3DSA:2.60.40.10. Ig-like_fold. 1 hit. G3DSA:3.30.500.10. MHC_I-like_Ag-recog. 1 hit.
Pfam	PF07654. C1-set. 1 hit. PF00129. MHC_I. 1 hit. PF06623. MHC_I_C. 1 hit. [Graphical view]
PRINTS	PR01638. MHCCLASSI.
SMART	SM00407. IGc1. 1 hit. [Graphical view]
SUPFAM	SSF54452. MHC_I/II-like_Ag-recog. 1 hit.
PROSITE	PS50835. IG_LIKE. 1 hit. PS00290. IG_MHC. 1 hit. [Graphical view]
ProtoNet	Search...
Other
SOURCE	Search...

Entry information

Entry name

1A26_HUMAN

Accession

Primary (citable) accession number: P30450
Secondary accession number(s): O02963 , O78073, P79563, Q30208, Q31623, Q95377, Q9BD15, Q9BD19, Q9MW42, Q9TQK5

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 1, 1993
Last sequence update:	November 1, 1995
Last modified:	December 14, 2011
This is version 108 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.