P30447 (1A23_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
HLA class I histocompatibility antigen, A-23 alpha chain

Alternative name(s):
HLA class I histocompatibility antigen, A-9 alpha chain
MHC class I antigen A*23

Gene names

Name:	HLA-A
Synonyms:	HLAA

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	365 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Involved in the presentation of foreign antigens to the immune system.
Subunit structure	Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8 MIR1 protein By similarity.
Subcellular location	Membrane; Single-pass type I membrane protein.
Post-translational modification	Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein. This targets the protein for rapid degradation via the ubiquitin system By similarity.
Polymorphism	The following alleles of A-23 are known: A*23:01, A*23:02, A*23:03, A*23:04 and A*23:05. The sequence shown is that of A*23:01.
Sequence similarities	Belongs to the MHC class I family. Contains 1 Ig-like C1-type (immunoglobulin-like) domain.

Ontologies

Keywords
Biological process	Host-virus interaction Immunity
Cellular component	MHC I Membrane
Coding sequence diversity	Polymorphism
Domain	Signal Transmembrane Transmembrane helix
PTM	Disulfide bond Glycoprotein Ubl conjugation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	antigen processing and presentation of peptide antigen via MHC class I Inferred from electronic annotation. Source: UniProtKB-KW immune response Inferred from electronic annotation. Source: InterPro interspecies interaction between organisms Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	MHC class I protein complex Inferred from electronic annotation. Source: UniProtKB-KW integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 24	24
	Chain	25 – 365	341	HLA class I histocompatibility antigen, A-23 alpha chain		PRO_0000018817
Regions
	Topological domain	25 – 308	284	Extracellular Potential
	Transmembrane	309 – 332	24	Helical; Potential
	Topological domain	333 – 365	33	Cytoplasmic Potential
	Domain	209 – 295	87	Ig-like C1-type
	Region	25 – 114	90	Alpha-1
	Region	115 – 206	92	Alpha-2
	Region	207 – 298	92	Alpha-3
	Region	299 – 308	10	Connecting peptide
Amino acid modifications
	Glycosylation	110	1	N-linked (GlcNAc...) By similarity
	Disulfide bond	125 ↔ 188		By similarity
	Disulfide bond	227 ↔ 283		By similarity
Natural variations
	Natural variant	31	1	Y → C in allele A*23:05.		VAR_016606
	Natural variant	151	1	K → N in allele A*23:03.		VAR_016607
	Natural variant	180	1	L → W in allele A*23:02.		VAR_016608
	Natural variant	190 – 191	2	DG → EW in allele A*23:04.		VAR_016609
	Natural variant	205	1	R → H. Corresponds to variant rs17185861 [ dbSNP | Ensembl ].		VAR_056262

Sequences

	Sequence		Length	Mass (Da)
	P30447 [UniParc]. Last modified April 1, 1993. Version 1. Checksum: C372DE503BF393D0	FASTA	365	40,733
	10 20 30 40 50 60 MAVMAPRTLV LLLSGALALT QTWAGSHSMR YFSTSVSRPG RGEPRFIAVG YVDDTQFVRF 70 80 90 100 110 120 DSDAASQRME PRAPWIEQEG PEYWDEETGK VKAHSQTDRE NLRIALRYYN QSEAGSHTLQ 130 140 150 160 170 180 MMFGCDVGSD GRFLRGYHQY AYDGKDYIAL KEDLRSWTAA DMAAQITQRK WEAARVAEQL 190 200 210 220 230 240 RAYLEGTCVD GLRRYLENGK ETLQRTDPPK THMTHHPISD HEATLRCWAL GFYPAEITLT 250 260 270 280 290 300 WQRDGEDQTQ DTELVETRPA GDGTFQKWAA VVVPSGEEQR YTCHVQHEGL PKPLTLRWEP 310 320 330 340 350 360 SSQPTVHIVG IIAGLVLLGA VITGAVVAAV MWRRNSSDRK GGSYSQAASS DSAQGSDVSL TACKV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular definition of an elusive third HLA-A9 molecule: HLA-A9.3." Little A.-M., Madrigal J.A., Parham P. Immunogenetics 35:41-45(1992) [PubMed: 1729171] [Abstract] Cited for: NUCLEOTIDE SEQUENCE (ALLELE A*23:01).
[2]	"Seventeen more novel HLA-A locus alleles." Ellis J., Steiner N.K., Kosman C., Henson V., Mitton W., Koester R., Ng J., Hartzman R.J., Hurley C.K. Tissue Antigens 55:369-373(2000) [PubMed: 10852390] [Abstract] Cited for: NUCLEOTIDE SEQUENCE OF 26-206 (ALLELES A*23:02 AND A*23:03).
[3]	"Seven novel HLA-A alleles carry previously observed polymorphisms." Steiner N.K., Edson S.M., Mitton W., Ng J., Hartzman R.J., Hurley C.K. Tissue Antigens 56:551-552(2000) [PubMed: 11169246] [Abstract] Cited for: NUCLEOTIDE SEQUENCE OF 26-206 (ALLELES A*23:04 AND A*23:05).
[4]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed: 21269460] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M64742 mRNA. Translation: AAA03662.1. AF137080, AF137079 Genomic DNA. Translation: AAD33736.1. AF102572, AF102571 Genomic DNA. Translation: AAD28171.1. AF135549, AF135548 Genomic DNA. Translation: AAD22272.1. AF140860, AF140859 Genomic DNA. Translation: AAD31878.1.
IPI	IPI00472151.
UniGene	Hs.181244. Hs.713441.
3D structure databases
ProteinModelPortal	P30447.
SMR	P30447. Positions 25-298.
ModBase	Search...
Protein-protein interaction databases
STRING	P30447.
Polymorphism databases
DMDM	231359.
Proteomic databases
PRIDE	P30447.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000442068; ENSP00000404428; ENSG00000223980. ENST00000454091; ENSP00000410645; ENSG00000223980.
Organism-specific databases
GeneCards	GC06P029921. GC06Po29897.
HGNC	HGNC:4931. HLA-A.
MIM	142800. gene.
neXtProt	NX_P30447.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	HBG016709.
OrthoDB	EOG4T783X.
Gene expression databases
CleanEx	HS_HLA-A.
Genevestigator	P30447.
GermOnline	ENSG00000204632. Homo sapiens.
Family and domain databases
InterPro	IPR007110. Ig-like. IPR013783. Ig-like_fold. IPR003006. Ig/MHC_CS. IPR003597. Ig_C1-set. IPR011161. MHC_I-like_Ag-recog. IPR011162. MHC_I/II-like_Ag-recog. IPR001039. MHC_I_a_a1/a2. IPR010579. MHC_I_a_C. [Graphical view]
Gene3D	G3DSA:2.60.40.10. Ig-like_fold. 1 hit. G3DSA:3.30.500.10. MHC_I-like_Ag-recog. 1 hit.
Pfam	PF07654. C1-set. 1 hit. PF00129. MHC_I. 1 hit. PF06623. MHC_I_C. 1 hit. [Graphical view]
PRINTS	PR01638. MHCCLASSI.
SMART	SM00407. IGc1. 1 hit. [Graphical view]
SUPFAM	SSF54452. MHC_I/II-like_Ag-recog. 1 hit.
PROSITE	PS50835. IG_LIKE. 1 hit. PS00290. IG_MHC. 1 hit. [Graphical view]
ProtoNet	Search...
Other
SOURCE	Search...

Entry information

Entry name

1A23_HUMAN

Accession

Primary (citable) accession number: P30447
Secondary accession number(s): Q9TQF1 , Q9TQF8, Q9TQG5, Q9TQM6

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 1, 1993
Last sequence update:	April 1, 1993
Last modified:	December 14, 2011
This is version 98 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.