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P30443

- 1A01_HUMAN

UniProt

P30443 - 1A01_HUMAN

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Protein

HLA class I histocompatibility antigen, A-1 alpha chain

Gene

HLA-A

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Involved in the presentation of foreign antigens to the immune system.

GO - Molecular functioni

  1. beta-2-microglobulin binding Source: UniProt
  2. peptide antigen binding Source: UniProt
  3. TAP binding Source: UniProt

GO - Biological processi

  1. antigen processing and presentation of exogenous peptide antigen via MHC class I Source: Reactome
  2. antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent Source: Reactome
  3. antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent Source: Reactome
  4. antigen processing and presentation of peptide antigen via MHC class I Source: Reactome
  5. cytokine-mediated signaling pathway Source: Reactome
  6. detection of bacterium Source: UniProtKB
  7. immune response Source: UniProtKB
  8. interferon-gamma-mediated signaling pathway Source: Reactome
  9. positive regulation of T cell mediated cytotoxicity Source: UniProt
  10. regulation of immune response Source: Reactome
  11. type I interferon signaling pathway Source: Reactome
  12. viral process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Host-virus interaction, Immunity

Enzyme and pathway databases

ReactomeiREACT_111168. Endosomal/Vacuolar pathway.
REACT_111178. ER-Phagosome pathway.
REACT_11152. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
REACT_25078. Interferon gamma signaling.
REACT_25162. Interferon alpha/beta signaling.
REACT_75795. Antigen Presentation: Folding, assembly and peptide loading of class I MHC.

Names & Taxonomyi

Protein namesi
Recommended name:
HLA class I histocompatibility antigen, A-1 alpha chain
Alternative name(s):
MHC class I antigen A*1
Gene namesi
Name:HLA-A
Synonyms:HLAA
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Unplaced

Organism-specific databases

HGNCiHGNC:4931. HLA-A.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini25 – 308284ExtracellularSequence AnalysisAdd
BLAST
Transmembranei309 – 33224HelicalSequence AnalysisAdd
BLAST
Topological domaini333 – 36533CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. cell surface Source: UniProt
  2. early endosome membrane Source: Reactome
  3. endoplasmic reticulum Source: UniProt
  4. ER to Golgi transport vesicle membrane Source: Reactome
  5. extracellular vesicular exosome Source: UniProt
  6. Golgi apparatus Source: UniProt
  7. Golgi membrane Source: Reactome
  8. integral component of lumenal side of endoplasmic reticulum membrane Source: Reactome
  9. integral component of plasma membrane Source: UniProtKB
  10. membrane Source: UniProtKB
  11. MHC class I protein complex Source: UniProt
  12. phagocytic vesicle membrane Source: Reactome
  13. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane, MHC I

Pathology & Biotechi

Organism-specific databases

Orphaneti179. Birdshot chorioretinopathy.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424Add
BLAST
Chaini25 – 365341HLA class I histocompatibility antigen, A-1 alpha chainPRO_0000018813Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei83 – 831SulfotyrosineSequence Analysis
Glycosylationi110 – 1101N-linked (GlcNAc...)1 Publication
Disulfide bondi125 ↔ 1881 PublicationPROSITE-ProRule annotation
Disulfide bondi227 ↔ 2831 PublicationPROSITE-ProRule annotation

Post-translational modificationi

Sulfated.1 Publication
Polyubiquitinated in a post ER compartment through interaction with human herpesvirus 8 MIR1 protein. This targets the protein for rapid degradation via the ubiquitin system (By similarity).By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Sulfation, Ubl conjugation

Proteomic databases

PaxDbiP30443.
PRIDEiP30443.

Expressioni

Gene expression databases

CleanExiHS_HLA-A.
GenevestigatoriP30443.

Interactioni

Subunit structurei

Dimer of alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8 MIR1 protein (By similarity).By similarity

Protein-protein interaction databases

BioGridi109350. 99 interactions.
IntActiP30443. 1 interaction.
MINTiMINT-4655826.

Structurei

Secondary structure

1
365
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi27 – 3610Combined sources
Beta strandi41 – 433Combined sources
Beta strandi45 – 528Combined sources
Beta strandi55 – 617Combined sources
Beta strandi64 – 663Combined sources
Beta strandi70 – 734Combined sources
Helixi74 – 763Combined sources
Helixi81 – 10929Combined sources
Beta strandi113 – 1153Combined sources
Beta strandi118 – 12710Combined sources
Beta strandi133 – 14210Combined sources
Beta strandi145 – 1506Combined sources
Beta strandi157 – 1593Combined sources
Helixi162 – 17312Combined sources
Helixi176 – 18510Combined sources
Helixi187 – 19812Combined sources
Helixi200 – 2034Combined sources
Beta strandi210 – 2178Combined sources
Beta strandi219 – 23517Combined sources
Beta strandi238 – 2436Combined sources
Beta strandi246 – 2483Combined sources
Helixi249 – 2513Combined sources
Beta strandi252 – 2543Combined sources
Beta strandi261 – 2633Combined sources
Beta strandi265 – 27410Combined sources
Helixi278 – 2803Combined sources
Beta strandi281 – 2866Combined sources
Beta strandi290 – 2923Combined sources
Beta strandi294 – 2963Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1W72X-ray2.15A/D25-298[»]
3BO8X-ray1.80A25-298[»]
4NQVX-ray2.39A/C/E/G/I/K25-298[»]
4NQXX-ray2.00A/C/E/G/I/K25-308[»]
ProteinModelPortaliP30443.
SMRiP30443. Positions 25-298.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP30443.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini209 – 29587Ig-like C1-typeAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni25 – 11490Alpha-1Add
BLAST
Regioni115 – 20692Alpha-2Add
BLAST
Regioni207 – 29892Alpha-3Add
BLAST
Regioni299 – 30810Connecting peptide

Sequence similaritiesi

Belongs to the MHC class I family.Curated

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG42056.
HOVERGENiHBG016709.
KOiK06751.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.30.500.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
IPR027648. MHC_I_a.
IPR001039. MHC_I_a_a1/a2.
IPR010579. MHC_I_a_C.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF00129. MHC_I. 1 hit.
PF06623. MHC_I_C. 1 hit.
[Graphical view]
PRINTSiPR01638. MHCCLASSI.
SMARTiSM00407. IGc1. 1 hit.
[Graphical view]
SUPFAMiSSF54452. SSF54452. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P30443-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAVMAPRTLL LLLSGALALT QTWAGSHSMR YFFTSVSRPG RGEPRFIAVG
60 70 80 90 100
YVDDTQFVRF DSDAASQKME PRAPWIEQEG PEYWDQETRN MKAHSQTDRA
110 120 130 140 150
NLGTLRGYYN QSEDGSHTIQ IMYGCDVGPD GRFLRGYRQD AYDGKDYIAL
160 170 180 190 200
NEDLRSWTAA DMAAQITKRK WEAVHAAEQR RVYLEGRCVD GLRRYLENGK
210 220 230 240 250
ETLQRTDPPK THMTHHPISD HEATLRCWAL GFYPAEITLT WQRDGEDQTQ
260 270 280 290 300
DTELVETRPA GDGTFQKWAA VVVPSGEEQR YTCHVQHEGL PKPLTLRWEL
310 320 330 340 350
SSQPTIPIVG IIAGLVLLGA VITGAVVAAV MWRRKSSDRK GGSYTQAASS
360
DSAQGSDVSL TACKV
Length:365
Mass (Da):40,846
Last modified:April 1, 1993 - v1
Checksum:i8667AFF3F06C4932
GO

Polymorphismi

The following alleles of A-1 are known: A*01:01, A*01:02, A*01:03, A*01:06 and A*01:07. The sequence shown is that of A*01:01.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti33 – 331F → S in allele A*01:02.
Corresponds to variant rs2075684 [ dbSNP | Ensembl ].
VAR_004332
Natural varianti41 – 411R → S in allele A*01:02.
VAR_004333
Natural varianti80 – 801G → R in allele A*01:07.
VAR_016719
Natural varianti89 – 891R → G.
Corresponds to variant rs1059459 [ dbSNP | Ensembl ].
VAR_056247
Natural varianti91 – 911M → V in allele A*01:07.
VAR_016720
Natural varianti100 – 1001A → E in allele A*01:07.
VAR_016721
Natural varianti114 – 1141D → A in allele A*01:07.
VAR_016722
Natural varianti121 – 1211I → M in allele A*01:03.
VAR_016723
Natural varianti131 – 1311G → W.
Corresponds to variant rs1136702 [ dbSNP | Ensembl ].
VAR_056248
Natural varianti133 – 1331F → L.
Corresponds to variant rs1059488 [ dbSNP | Ensembl ].
VAR_056249
Natural varianti151 – 1511N → K.
Corresponds to variant rs1059509 [ dbSNP | Ensembl ].
VAR_056250
Natural varianti166 – 1661I → T.1 Publication
Corresponds to variant rs1059516 [ dbSNP | Ensembl ].
VAR_056251
Natural varianti169 – 1691R → H.
Corresponds to variant rs1059520 [ dbSNP | Ensembl ].
VAR_056252
Natural varianti180 – 1801R → L in allele A*01:06.
VAR_016724
Natural varianti182 – 1821V → A in allele A*01:06.
VAR_016725
Natural varianti205 – 2051R → H.
Corresponds to variant rs17185861 [ dbSNP | Ensembl ].
VAR_056253

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M24043 Genomic DNA. Translation: AAA59652.1.
X55710 Genomic DNA. Translation: CAA39243.1.
Z93949 Genomic DNA. Translation: CAB07989.1.
AJ278305 Genomic DNA. Translation: CAB93537.1.
BC003069 mRNA. Translation: AAH03069.1.
U07161 mRNA. Translation: AAA80569.1.
Y12469 Genomic DNA. Translation: CAA73072.1.
Y12470 Genomic DNA. Translation: CAA73073.1.
AH008863 Genomic DNA. Translation: AAF19525.1.
AH007762 Genomic DNA. Translation: AAD33894.1.
AH009407 Genomic DNA. Translation: AAF73862.1.
PIRiI38518.
I61856.
RefSeqiNP_001229687.1. NM_001242758.1.
UniGeneiHs.181244.
Hs.713441.

Genome annotation databases

EnsembliENST00000431930; ENSP00000406366; ENSG00000229215.
ENST00000443552; ENSP00000404678; ENSG00000224320.
ENST00000549869; ENSP00000447635; ENSG00000224320.
ENST00000552193; ENSP00000447614; ENSG00000229215.
GeneIDi3105.
KEGGihsa:3105.
UCSCiuc011ejp.2. human.

Polymorphism databases

DMDMi231347.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M24043 Genomic DNA. Translation: AAA59652.1 .
X55710 Genomic DNA. Translation: CAA39243.1 .
Z93949 Genomic DNA. Translation: CAB07989.1 .
AJ278305 Genomic DNA. Translation: CAB93537.1 .
BC003069 mRNA. Translation: AAH03069.1 .
U07161 mRNA. Translation: AAA80569.1 .
Y12469 Genomic DNA. Translation: CAA73072.1 .
Y12470 Genomic DNA. Translation: CAA73073.1 .
AH008863 Genomic DNA. Translation: AAF19525.1 .
AH007762 Genomic DNA. Translation: AAD33894.1 .
AH009407 Genomic DNA. Translation: AAF73862.1 .
PIRi I38518.
I61856.
RefSeqi NP_001229687.1. NM_001242758.1.
UniGenei Hs.181244.
Hs.713441.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1W72 X-ray 2.15 A/D 25-298 [» ]
3BO8 X-ray 1.80 A 25-298 [» ]
4NQV X-ray 2.39 A/C/E/G/I/K 25-298 [» ]
4NQX X-ray 2.00 A/C/E/G/I/K 25-308 [» ]
ProteinModelPortali P30443.
SMRi P30443. Positions 25-298.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 109350. 99 interactions.
IntActi P30443. 1 interaction.
MINTi MINT-4655826.

Polymorphism databases

DMDMi 231347.

Proteomic databases

PaxDbi P30443.
PRIDEi P30443.

Protocols and materials databases

DNASUi 3105.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000431930 ; ENSP00000406366 ; ENSG00000229215 .
ENST00000443552 ; ENSP00000404678 ; ENSG00000224320 .
ENST00000549869 ; ENSP00000447635 ; ENSG00000224320 .
ENST00000552193 ; ENSP00000447614 ; ENSG00000229215 .
GeneIDi 3105.
KEGGi hsa:3105.
UCSCi uc011ejp.2. human.

Organism-specific databases

CTDi 3105.
GeneCardsi GC06P030186.
GC06Pi29846.
GC06Pj29898.
HGNCi HGNC:4931. HLA-A.
MIMi 142800. gene.
neXtProti NX_P30443.
Orphaneti 179. Birdshot chorioretinopathy.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG42056.
HOVERGENi HBG016709.
KOi K06751.

Enzyme and pathway databases

Reactomei REACT_111168. Endosomal/Vacuolar pathway.
REACT_111178. ER-Phagosome pathway.
REACT_11152. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
REACT_25078. Interferon gamma signaling.
REACT_25162. Interferon alpha/beta signaling.
REACT_75795. Antigen Presentation: Folding, assembly and peptide loading of class I MHC.

Miscellaneous databases

ChiTaRSi HLA-A. human.
EvolutionaryTracei P30443.
GenomeRNAii 3105.
NextBioi 12319.
SOURCEi Search...

Gene expression databases

CleanExi HS_HLA-A.
Genevestigatori P30443.

Family and domain databases

Gene3Di 2.60.40.10. 1 hit.
3.30.500.10. 1 hit.
InterProi IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
IPR027648. MHC_I_a.
IPR001039. MHC_I_a_a1/a2.
IPR010579. MHC_I_a_C.
[Graphical view ]
Pfami PF07654. C1-set. 1 hit.
PF00129. MHC_I. 1 hit.
PF06623. MHC_I_C. 1 hit.
[Graphical view ]
PRINTSi PR01638. MHCCLASSI.
SMARTi SM00407. IGc1. 1 hit.
[Graphical view ]
SUPFAMi SSF54452. SSF54452. 1 hit.
PROSITEi PS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE (ALLELE A*01:01).
  2. "Diversity and diversification of HLA-A,B,C alleles."
    Parham P., Lawlor D.A., Lomen C.E., Ennis P.D.
    J. Immunol. 142:3937-3950(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE (ALLELE A*01:01).
  3. Warren E.
    Submitted (APR-1989) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE (ALLELE A*01:01).
  4. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE A*01:01).
  5. "A nucleotide insertion in exon 4 is responsible for the absence of expression of an HLA-A*01 allele."
    Laforet M., Froelich N., Parissiadis A., Pfeiffer B., Schell A., Faller B., Woehl-Jaegle M.L., Cazenave J.-P., Tongio M.M.
    Tissue Antigens 50:347-350(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE A*01:01).
  6. Waller M.J., Robinson J., Marsh S.G.E.
    Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE (ALLELE A*01:01).
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ALLELE A*01:01).
    Tissue: Brain.
  8. "The HLA-A,B,C genotype of the class I negative cell line Daudi reveals novel HLA-A and -B alleles."
    Browning M.J., Madrigal J.A., Krausa P., Kowalski H., Allsopp C.E., Little A.-M., Turner S., Adams E.J., Arnett K.L., Bodmer W.F., Parham P.
    Tissue Antigens 45:177-187(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE A*01:02).
  9. Cited for: NUCLEOTIDE SEQUENCE OF 26-206 (ALLELE A*01:03).
  10. Cited for: NUCLEOTIDE SEQUENCE OF 26-206 (ALLELE A*01:03).
    Tissue: Blood.
  11. Cited for: NUCLEOTIDE SEQUENCE OF 26-206 (ALLELE A*01:06).
  12. "A new HLA-A*01 allele."
    Tamouza R., Fortier C., Mahfoudh N., Schaeffer V., Poirier J.C., Marzais F., Gautreau C., Charron D.
    Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE OF 26-206 (ALLELE A*01:07).
  13. "Human Ia alpha- and beta-chains are sulfated."
    Sant A.J., Zacheis M., Rumbarger T., Giacoletto K.S., Schwartz B.D.
    J. Immunol. 140:155-160(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: SULFATION.
  14. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
    Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
    J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-110.
    Tissue: Liver.
  15. "A major histocompatibility complex-peptide-restricted antibody and t cell receptor molecules recognize their target by distinct binding modes: crystal structure of human leukocyte antigen (HLA)-A1-MAGE-A1 in complex with FAB-HYB3."
    Hulsmeyer M., Chames P., Hillig R.C., Stanfield R.L., Held G., Coulie P.G., Alings C., Wille G., Saenger W., Uchanska-Ziegler B., Hoogenboom H.R., Ziegler A.
    J. Biol. Chem. 280:2972-2980(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.15 ANGSTROMS) OF 25-298 IN COMPLEX WITH MAGE ANTIGENIC PEPTIDE AND ANTIBODY, DISULFIDE BONDS.
  16. Cited for: VARIANT [LARGE SCALE ANALYSIS] THR-166, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry namei1A01_HUMAN
AccessioniPrimary (citable) accession number: P30443
Secondary accession number(s): O77964
, O78171, Q9MYA3, Q9TP25, Q9TQP5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: November 26, 2014
This is version 135 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3