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P30443

- 1A01_HUMAN

UniProt

P30443 - 1A01_HUMAN

Protein

HLA class I histocompatibility antigen, A-1 alpha chain

Gene

HLA-A

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 133 (01 Oct 2014)
      Sequence version 1 (01 Apr 1993)
      Previous versions | rss
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    Functioni

    Involved in the presentation of foreign antigens to the immune system.

    GO - Molecular functioni

    1. beta-2-microglobulin binding Source: UniProt
    2. peptide antigen binding Source: UniProt
    3. TAP binding Source: UniProt

    GO - Biological processi

    1. antigen processing and presentation of exogenous peptide antigen via MHC class I Source: Reactome
    2. antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent Source: Reactome
    3. antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent Source: Reactome
    4. antigen processing and presentation of peptide antigen via MHC class I Source: Reactome
    5. cytokine-mediated signaling pathway Source: Reactome
    6. detection of bacterium Source: UniProtKB
    7. immune response Source: UniProtKB
    8. interferon-gamma-mediated signaling pathway Source: Reactome
    9. positive regulation of T cell mediated cytotoxicity Source: UniProt
    10. regulation of immune response Source: Reactome
    11. type I interferon signaling pathway Source: Reactome
    12. viral process Source: UniProtKB-KW

    Keywords - Biological processi

    Host-virus interaction, Immunity

    Enzyme and pathway databases

    ReactomeiREACT_111168. Endosomal/Vacuolar pathway.
    REACT_111178. ER-Phagosome pathway.
    REACT_11152. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
    REACT_25078. Interferon gamma signaling.
    REACT_25162. Interferon alpha/beta signaling.
    REACT_75795. Antigen Presentation: Folding, assembly and peptide loading of class I MHC.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    HLA class I histocompatibility antigen, A-1 alpha chain
    Alternative name(s):
    MHC class I antigen A*1
    Gene namesi
    Name:HLA-A
    Synonyms:HLAA
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Unplaced

    Organism-specific databases

    HGNCiHGNC:4931. HLA-A.

    Subcellular locationi

    GO - Cellular componenti

    1. cell surface Source: UniProt
    2. early endosome membrane Source: Reactome
    3. endoplasmic reticulum Source: UniProt
    4. ER to Golgi transport vesicle membrane Source: Reactome
    5. extracellular vesicular exosome Source: UniProt
    6. Golgi apparatus Source: UniProt
    7. Golgi membrane Source: Reactome
    8. integral component of lumenal side of endoplasmic reticulum membrane Source: Reactome
    9. integral component of plasma membrane Source: UniProtKB
    10. membrane Source: UniProtKB
    11. MHC class I protein complex Source: UniProt
    12. phagocytic vesicle membrane Source: Reactome
    13. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Membrane, MHC I

    Pathology & Biotechi

    Organism-specific databases

    Orphaneti179. Chorioretinopathy, Birdshot type.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2424Add
    BLAST
    Chaini25 – 365341HLA class I histocompatibility antigen, A-1 alpha chainPRO_0000018813Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei83 – 831SulfotyrosineSequence Analysis
    Glycosylationi110 – 1101N-linked (GlcNAc...)1 Publication
    Disulfide bondi125 ↔ 1881 PublicationPROSITE-ProRule annotation
    Disulfide bondi227 ↔ 2831 PublicationPROSITE-ProRule annotation

    Post-translational modificationi

    Sulfated.1 Publication
    Polyubiquitinated in a post ER compartment through interaction with human herpesvirus 8 MIR1 protein. This targets the protein for rapid degradation via the ubiquitin system By similarity.By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Sulfation, Ubl conjugation

    Proteomic databases

    PaxDbiP30443.
    PRIDEiP30443.

    Expressioni

    Gene expression databases

    CleanExiHS_HLA-A.
    GenevestigatoriP30443.

    Interactioni

    Subunit structurei

    Dimer of alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8 MIR1 protein By similarity.By similarity

    Protein-protein interaction databases

    BioGridi109350. 35 interactions.
    IntActiP30443. 1 interaction.
    MINTiMINT-4655826.

    Structurei

    Secondary structure

    1
    365
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi27 – 3610
    Beta strandi41 – 433
    Beta strandi45 – 528
    Beta strandi55 – 617
    Beta strandi64 – 663
    Beta strandi70 – 734
    Helixi74 – 763
    Helixi81 – 10929
    Beta strandi113 – 1153
    Beta strandi118 – 12710
    Beta strandi133 – 14210
    Beta strandi145 – 1506
    Beta strandi157 – 1593
    Helixi162 – 17312
    Helixi176 – 18510
    Helixi187 – 19812
    Helixi200 – 2034
    Beta strandi210 – 2178
    Beta strandi219 – 23517
    Beta strandi238 – 2436
    Beta strandi246 – 2483
    Helixi249 – 2513
    Beta strandi252 – 2543
    Beta strandi261 – 2633
    Beta strandi265 – 27410
    Helixi278 – 2803
    Beta strandi281 – 2866
    Beta strandi290 – 2923
    Beta strandi294 – 2963

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1W72X-ray2.15A/D25-298[»]
    3BO8X-ray1.80A25-298[»]
    4NQVX-ray2.39A/C/E/G/I/K25-298[»]
    4NQXX-ray2.00A/C/E/G/I/K25-308[»]
    ProteinModelPortaliP30443.
    SMRiP30443. Positions 25-298.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP30443.

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini25 – 308284ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini333 – 36533CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei309 – 33224HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini209 – 29587Ig-like C1-typeAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni25 – 11490Alpha-1Add
    BLAST
    Regioni115 – 20692Alpha-2Add
    BLAST
    Regioni207 – 29892Alpha-3Add
    BLAST
    Regioni299 – 30810Connecting peptide

    Sequence similaritiesi

    Belongs to the MHC class I family.Curated

    Keywords - Domaini

    Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG42056.
    HOVERGENiHBG016709.
    KOiK06751.

    Family and domain databases

    Gene3Di2.60.40.10. 1 hit.
    3.30.500.10. 1 hit.
    InterProiIPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003006. Ig/MHC_CS.
    IPR003597. Ig_C1-set.
    IPR011161. MHC_I-like_Ag-recog.
    IPR011162. MHC_I/II-like_Ag-recog.
    IPR027648. MHC_I_a.
    IPR001039. MHC_I_a_a1/a2.
    IPR010579. MHC_I_a_C.
    [Graphical view]
    PfamiPF07654. C1-set. 1 hit.
    PF00129. MHC_I. 1 hit.
    PF06623. MHC_I_C. 1 hit.
    [Graphical view]
    PRINTSiPR01638. MHCCLASSI.
    SMARTiSM00407. IGc1. 1 hit.
    [Graphical view]
    SUPFAMiSSF54452. SSF54452. 1 hit.
    PROSITEiPS50835. IG_LIKE. 1 hit.
    PS00290. IG_MHC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P30443-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAVMAPRTLL LLLSGALALT QTWAGSHSMR YFFTSVSRPG RGEPRFIAVG    50
    YVDDTQFVRF DSDAASQKME PRAPWIEQEG PEYWDQETRN MKAHSQTDRA 100
    NLGTLRGYYN QSEDGSHTIQ IMYGCDVGPD GRFLRGYRQD AYDGKDYIAL 150
    NEDLRSWTAA DMAAQITKRK WEAVHAAEQR RVYLEGRCVD GLRRYLENGK 200
    ETLQRTDPPK THMTHHPISD HEATLRCWAL GFYPAEITLT WQRDGEDQTQ 250
    DTELVETRPA GDGTFQKWAA VVVPSGEEQR YTCHVQHEGL PKPLTLRWEL 300
    SSQPTIPIVG IIAGLVLLGA VITGAVVAAV MWRRKSSDRK GGSYTQAASS 350
    DSAQGSDVSL TACKV 365
    Length:365
    Mass (Da):40,846
    Last modified:April 1, 1993 - v1
    Checksum:i8667AFF3F06C4932
    GO

    Polymorphismi

    The following alleles of A-1 are known: A*01:01, A*01:02, A*01:03, A*01:06 and A*01:07. The sequence shown is that of A*01:01.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti33 – 331F → S in allele A*01:02.
    Corresponds to variant rs2075684 [ dbSNP | Ensembl ].
    VAR_004332
    Natural varianti41 – 411R → S in allele A*01:02.
    VAR_004333
    Natural varianti80 – 801G → R in allele A*01:07.
    VAR_016719
    Natural varianti89 – 891R → G.
    Corresponds to variant rs1059459 [ dbSNP | Ensembl ].
    VAR_056247
    Natural varianti91 – 911M → V in allele A*01:07.
    VAR_016720
    Natural varianti100 – 1001A → E in allele A*01:07.
    VAR_016721
    Natural varianti114 – 1141D → A in allele A*01:07.
    VAR_016722
    Natural varianti121 – 1211I → M in allele A*01:03.
    VAR_016723
    Natural varianti131 – 1311G → W.
    Corresponds to variant rs1136702 [ dbSNP | Ensembl ].
    VAR_056248
    Natural varianti133 – 1331F → L.
    Corresponds to variant rs1059488 [ dbSNP | Ensembl ].
    VAR_056249
    Natural varianti151 – 1511N → K.
    Corresponds to variant rs1059509 [ dbSNP | Ensembl ].
    VAR_056250
    Natural varianti166 – 1661I → T.1 Publication
    Corresponds to variant rs1059516 [ dbSNP | Ensembl ].
    VAR_056251
    Natural varianti169 – 1691R → H.
    Corresponds to variant rs1059520 [ dbSNP | Ensembl ].
    VAR_056252
    Natural varianti180 – 1801R → L in allele A*01:06.
    VAR_016724
    Natural varianti182 – 1821V → A in allele A*01:06.
    VAR_016725
    Natural varianti205 – 2051R → H.
    Corresponds to variant rs17185861 [ dbSNP | Ensembl ].
    VAR_056253

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M24043 Genomic DNA. Translation: AAA59652.1.
    X55710 Genomic DNA. Translation: CAA39243.1.
    Z93949 Genomic DNA. Translation: CAB07989.1.
    AJ278305 Genomic DNA. Translation: CAB93537.1.
    BC003069 mRNA. Translation: AAH03069.1.
    U07161 mRNA. Translation: AAA80569.1.
    Y12469 Genomic DNA. Translation: CAA73072.1.
    Y12470 Genomic DNA. Translation: CAA73073.1.
    AH008863 Genomic DNA. Translation: AAF19525.1.
    AH007762 Genomic DNA. Translation: AAD33894.1.
    AH009407 Genomic DNA. Translation: AAF73862.1.
    CCDSiCCDS34373.1.
    PIRiI38518.
    I61856.
    RefSeqiNP_001229687.1. NM_001242758.1.
    UniGeneiHs.181244.
    Hs.713441.

    Genome annotation databases

    EnsembliENST00000431930; ENSP00000406366; ENSG00000229215.
    ENST00000443552; ENSP00000404678; ENSG00000224320.
    ENST00000549869; ENSP00000447635; ENSG00000224320.
    ENST00000552193; ENSP00000447614; ENSG00000229215.
    GeneIDi3105.
    KEGGihsa:3105.
    UCSCiuc011ejp.2. human.

    Polymorphism databases

    DMDMi231347.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M24043 Genomic DNA. Translation: AAA59652.1 .
    X55710 Genomic DNA. Translation: CAA39243.1 .
    Z93949 Genomic DNA. Translation: CAB07989.1 .
    AJ278305 Genomic DNA. Translation: CAB93537.1 .
    BC003069 mRNA. Translation: AAH03069.1 .
    U07161 mRNA. Translation: AAA80569.1 .
    Y12469 Genomic DNA. Translation: CAA73072.1 .
    Y12470 Genomic DNA. Translation: CAA73073.1 .
    AH008863 Genomic DNA. Translation: AAF19525.1 .
    AH007762 Genomic DNA. Translation: AAD33894.1 .
    AH009407 Genomic DNA. Translation: AAF73862.1 .
    CCDSi CCDS34373.1.
    PIRi I38518.
    I61856.
    RefSeqi NP_001229687.1. NM_001242758.1.
    UniGenei Hs.181244.
    Hs.713441.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1W72 X-ray 2.15 A/D 25-298 [» ]
    3BO8 X-ray 1.80 A 25-298 [» ]
    4NQV X-ray 2.39 A/C/E/G/I/K 25-298 [» ]
    4NQX X-ray 2.00 A/C/E/G/I/K 25-308 [» ]
    ProteinModelPortali P30443.
    SMRi P30443. Positions 25-298.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 109350. 35 interactions.
    IntActi P30443. 1 interaction.
    MINTi MINT-4655826.

    Polymorphism databases

    DMDMi 231347.

    Proteomic databases

    PaxDbi P30443.
    PRIDEi P30443.

    Protocols and materials databases

    DNASUi 3105.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000431930 ; ENSP00000406366 ; ENSG00000229215 .
    ENST00000443552 ; ENSP00000404678 ; ENSG00000224320 .
    ENST00000549869 ; ENSP00000447635 ; ENSG00000224320 .
    ENST00000552193 ; ENSP00000447614 ; ENSG00000229215 .
    GeneIDi 3105.
    KEGGi hsa:3105.
    UCSCi uc011ejp.2. human.

    Organism-specific databases

    CTDi 3105.
    GeneCardsi GC06P029949.
    GC06Pi29846.
    GC06Pj29898.
    HGNCi HGNC:4931. HLA-A.
    MIMi 142800. gene.
    neXtProti NX_P30443.
    Orphaneti 179. Chorioretinopathy, Birdshot type.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG42056.
    HOVERGENi HBG016709.
    KOi K06751.

    Enzyme and pathway databases

    Reactomei REACT_111168. Endosomal/Vacuolar pathway.
    REACT_111178. ER-Phagosome pathway.
    REACT_11152. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
    REACT_25078. Interferon gamma signaling.
    REACT_25162. Interferon alpha/beta signaling.
    REACT_75795. Antigen Presentation: Folding, assembly and peptide loading of class I MHC.

    Miscellaneous databases

    ChiTaRSi HLA-A. human.
    EvolutionaryTracei P30443.
    GenomeRNAii 3105.
    NextBioi 12319.
    SOURCEi Search...

    Gene expression databases

    CleanExi HS_HLA-A.
    Genevestigatori P30443.

    Family and domain databases

    Gene3Di 2.60.40.10. 1 hit.
    3.30.500.10. 1 hit.
    InterProi IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003006. Ig/MHC_CS.
    IPR003597. Ig_C1-set.
    IPR011161. MHC_I-like_Ag-recog.
    IPR011162. MHC_I/II-like_Ag-recog.
    IPR027648. MHC_I_a.
    IPR001039. MHC_I_a_a1/a2.
    IPR010579. MHC_I_a_C.
    [Graphical view ]
    Pfami PF07654. C1-set. 1 hit.
    PF00129. MHC_I. 1 hit.
    PF06623. MHC_I_C. 1 hit.
    [Graphical view ]
    PRINTSi PR01638. MHCCLASSI.
    SMARTi SM00407. IGc1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54452. SSF54452. 1 hit.
    PROSITEi PS50835. IG_LIKE. 1 hit.
    PS00290. IG_MHC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE (ALLELE A*01:01).
    2. "Diversity and diversification of HLA-A,B,C alleles."
      Parham P., Lawlor D.A., Lomen C.E., Ennis P.D.
      J. Immunol. 142:3937-3950(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE (ALLELE A*01:01).
    3. Warren E.
      Submitted (APR-1989) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE (ALLELE A*01:01).
    4. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE A*01:01).
    5. "A nucleotide insertion in exon 4 is responsible for the absence of expression of an HLA-A*01 allele."
      Laforet M., Froelich N., Parissiadis A., Pfeiffer B., Schell A., Faller B., Woehl-Jaegle M.L., Cazenave J.-P., Tongio M.M.
      Tissue Antigens 50:347-350(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE A*01:01).
    6. Waller M.J., Robinson J., Marsh S.G.E.
      Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE (ALLELE A*01:01).
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ALLELE A*01:01).
      Tissue: Brain.
    8. "The HLA-A,B,C genotype of the class I negative cell line Daudi reveals novel HLA-A and -B alleles."
      Browning M.J., Madrigal J.A., Krausa P., Kowalski H., Allsopp C.E., Little A.-M., Turner S., Adams E.J., Arnett K.L., Bodmer W.F., Parham P.
      Tissue Antigens 45:177-187(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE A*01:02).
    9. Cited for: NUCLEOTIDE SEQUENCE OF 26-206 (ALLELE A*01:03).
    10. Cited for: NUCLEOTIDE SEQUENCE OF 26-206 (ALLELE A*01:03).
      Tissue: Blood.
    11. Cited for: NUCLEOTIDE SEQUENCE OF 26-206 (ALLELE A*01:06).
    12. "A new HLA-A*01 allele."
      Tamouza R., Fortier C., Mahfoudh N., Schaeffer V., Poirier J.C., Marzais F., Gautreau C., Charron D.
      Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE OF 26-206 (ALLELE A*01:07).
    13. "Human Ia alpha- and beta-chains are sulfated."
      Sant A.J., Zacheis M., Rumbarger T., Giacoletto K.S., Schwartz B.D.
      J. Immunol. 140:155-160(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: SULFATION.
    14. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
      Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
      J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-110.
      Tissue: Liver.
    15. "A major histocompatibility complex-peptide-restricted antibody and t cell receptor molecules recognize their target by distinct binding modes: crystal structure of human leukocyte antigen (HLA)-A1-MAGE-A1 in complex with FAB-HYB3."
      Hulsmeyer M., Chames P., Hillig R.C., Stanfield R.L., Held G., Coulie P.G., Alings C., Wille G., Saenger W., Uchanska-Ziegler B., Hoogenboom H.R., Ziegler A.
      J. Biol. Chem. 280:2972-2980(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.15 ANGSTROMS) OF 25-298 IN COMPLEX WITH MAGE ANTIGENIC PEPTIDE AND ANTIBODY, DISULFIDE BONDS.
    16. Cited for: VARIANT [LARGE SCALE ANALYSIS] THR-166, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry namei1A01_HUMAN
    AccessioniPrimary (citable) accession number: P30443
    Secondary accession number(s): O77964
    , O78171, Q9MYA3, Q9TP25, Q9TQP5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 1, 1993
    Last sequence update: April 1, 1993
    Last modified: October 1, 2014
    This is version 133 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3