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Protein

HLA class I histocompatibility antigen, A-1 alpha chain

Gene

HLA-A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in the presentation of foreign antigens to the immune system.

GO - Molecular functioni

  • beta-2-microglobulin binding Source: UniProtKB
  • peptide antigen binding Source: UniProtKB
  • TAP binding Source: UniProtKB

GO - Biological processi

Keywordsi

Biological processHost-virus interaction, Immunity

Enzyme and pathway databases

ReactomeiR-HSA-1236974 ER-Phagosome pathway
R-HSA-1236977 Endosomal/Vacuolar pathway
R-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
R-HSA-877300 Interferon gamma signaling
R-HSA-909733 Interferon alpha/beta signaling
R-HSA-983170 Antigen Presentation: Folding, assembly and peptide loading of class I MHC
SIGNORiP30443

Names & Taxonomyi

Protein namesi
Recommended name:
HLA class I histocompatibility antigen, A-1 alpha chain
Alternative name(s):
MHC class I antigen A*1
Gene namesi
Name:HLA-A
Synonyms:HLAA
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:4931 HLA-A
MIMi142800 gene
neXtProtiNX_P30443

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini25 – 308ExtracellularSequence analysisAdd BLAST284
Transmembranei309 – 332HelicalSequence analysisAdd BLAST24
Topological domaini333 – 365CytoplasmicSequence analysisAdd BLAST33

Keywords - Cellular componenti

Membrane, MHC I

Pathology & Biotechi

Organism-specific databases

DisGeNETi3105
MalaCardsiHLA-A
Orphaneti179 Birdshot chorioretinopathy

Polymorphism and mutation databases

DMDMi231347

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Add BLAST24
ChainiPRO_000001881325 – 365HLA class I histocompatibility antigen, A-1 alpha chainAdd BLAST341

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei83SulfotyrosineSequence analysis1
Glycosylationi110N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi125 ↔ 188PROSITE-ProRule annotation1 Publication
Disulfide bondi227 ↔ 283PROSITE-ProRule annotation1 Publication
Modified residuei343PhosphoserineBy similarity1
Modified residuei344PhosphotyrosineBy similarity1
Modified residuei349PhosphoserineBy similarity1
Modified residuei350PhosphoserineBy similarity1
Modified residuei352PhosphoserineCombined sources1
Modified residuei356PhosphoserineCombined sources1
Modified residuei359PhosphoserineCombined sources1

Post-translational modificationi

Sulfated.1 Publication
Polyubiquitinated in a post ER compartment through interaction with human herpesvirus 8 MIR1 protein. This targets the protein for rapid degradation via the ubiquitin system (By similarity).By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein, Sulfation, Ubl conjugation

Proteomic databases

PeptideAtlasiP30443
PRIDEiP30443

PTM databases

iPTMnetiP30443
PhosphoSitePlusiP30443
SwissPalmiP30443

Expressioni

Gene expression databases

CleanExiHS_HLA-A

Interactioni

Subunit structurei

Dimer of alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8 MIR1 protein (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
KIR3DS1Q149432EBI-8561769,EBI-15316524

GO - Molecular functioni

  • beta-2-microglobulin binding Source: UniProtKB
  • TAP binding Source: UniProtKB

Protein-protein interaction databases

BioGridi109350, 90 interactors
IntActiP30443, 6 interactors
MINTiP30443

Structurei

Secondary structure

1365
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi27 – 36Combined sources10
Beta strandi41 – 43Combined sources3
Beta strandi45 – 52Combined sources8
Beta strandi55 – 61Combined sources7
Beta strandi64 – 66Combined sources3
Beta strandi70 – 73Combined sources4
Helixi74 – 76Combined sources3
Helixi81 – 109Combined sources29
Beta strandi113 – 115Combined sources3
Beta strandi118 – 127Combined sources10
Beta strandi133 – 142Combined sources10
Beta strandi145 – 150Combined sources6
Beta strandi157 – 159Combined sources3
Helixi162 – 173Combined sources12
Helixi176 – 185Combined sources10
Helixi187 – 198Combined sources12
Helixi200 – 203Combined sources4
Beta strandi210 – 217Combined sources8
Beta strandi219 – 235Combined sources17
Beta strandi238 – 243Combined sources6
Beta strandi246 – 248Combined sources3
Helixi249 – 251Combined sources3
Beta strandi252 – 254Combined sources3
Beta strandi261 – 263Combined sources3
Beta strandi265 – 274Combined sources10
Helixi278 – 280Combined sources3
Beta strandi281 – 286Combined sources6
Beta strandi290 – 292Combined sources3
Beta strandi294 – 296Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1W72X-ray2.15A/D25-298[»]
3BO8X-ray1.80A25-298[»]
4NQVX-ray2.39A/C/E/G/I/K25-298[»]
4NQXX-ray2.00A/C/E/G/I/K25-308[»]
5BRZX-ray2.62A25-298[»]
5BS0X-ray2.40A25-298[»]
6AT9X-ray2.95A25-304[»]
ProteinModelPortaliP30443
SMRiP30443
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP30443

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini209 – 295Ig-like C1-typeAdd BLAST87

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni25 – 114Alpha-1Add BLAST90
Regioni115 – 206Alpha-2Add BLAST92
Regioni207 – 298Alpha-3Add BLAST92
Regioni299 – 308Connecting peptide10

Sequence similaritiesi

Belongs to the MHC class I family.Curated

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410II5V Eukaryota
ENOG4111K8F LUCA
HOVERGENiHBG016709
KOiK06751

Family and domain databases

Gene3Di2.60.40.10, 1 hit
3.30.500.10, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003006 Ig/MHC_CS
IPR003597 Ig_C1-set
IPR011161 MHC_I-like_Ag-recog
IPR037055 MHC_I-like_Ag-recog_sf
IPR011162 MHC_I/II-like_Ag-recog
IPR001039 MHC_I_a_a1/a2
IPR010579 MHC_I_a_C
PfamiView protein in Pfam
PF07654 C1-set, 1 hit
PF00129 MHC_I, 1 hit
PF06623 MHC_I_C, 1 hit
PRINTSiPR01638 MHCCLASSI
SMARTiView protein in SMART
SM00407 IGc1, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
SSF54452 SSF54452, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
PS00290 IG_MHC, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P30443-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVMAPRTLL LLLSGALALT QTWAGSHSMR YFFTSVSRPG RGEPRFIAVG
60 70 80 90 100
YVDDTQFVRF DSDAASQKME PRAPWIEQEG PEYWDQETRN MKAHSQTDRA
110 120 130 140 150
NLGTLRGYYN QSEDGSHTIQ IMYGCDVGPD GRFLRGYRQD AYDGKDYIAL
160 170 180 190 200
NEDLRSWTAA DMAAQITKRK WEAVHAAEQR RVYLEGRCVD GLRRYLENGK
210 220 230 240 250
ETLQRTDPPK THMTHHPISD HEATLRCWAL GFYPAEITLT WQRDGEDQTQ
260 270 280 290 300
DTELVETRPA GDGTFQKWAA VVVPSGEEQR YTCHVQHEGL PKPLTLRWEL
310 320 330 340 350
SSQPTIPIVG IIAGLVLLGA VITGAVVAAV MWRRKSSDRK GGSYTQAASS
360
DSAQGSDVSL TACKV
Length:365
Mass (Da):40,846
Last modified:April 1, 1993 - v1
Checksum:i8667AFF3F06C4932
GO

Polymorphismi

The following alleles of A-1 are known: A*01:01, A*01:02, A*01:03, A*01:06 and A*01:07. The sequence shown is that of A*01:01.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_00433233F → S in allele A*01:02. 1 PublicationCorresponds to variant dbSNP:rs2075684Ensembl.1
Natural variantiVAR_00433341R → S in allele A*01:02. 1 PublicationCorresponds to variant dbSNP:rs1059423Ensembl.1
Natural variantiVAR_01671980G → R in allele A*01:07. 1 PublicationCorresponds to variant dbSNP:rs1059449Ensembl.1
Natural variantiVAR_05624789R → G1 PublicationCorresponds to variant dbSNP:rs199474430Ensembl.1
Natural variantiVAR_01672091M → V in allele A*01:07. 1 PublicationCorresponds to variant dbSNP:rs79361534Ensembl.1
Natural variantiVAR_016721100A → E in allele A*01:07. 1 PublicationCorresponds to variant dbSNP:rs1071742Ensembl.1
Natural variantiVAR_016722114D → A in allele A*01:07. 1 PublicationCorresponds to variant dbSNP:rs1136692Ensembl.1
Natural variantiVAR_016723121I → M in allele A*01:03. 2 PublicationsCorresponds to variant dbSNP:rs1136695Ensembl.1
Natural variantiVAR_056248131G → W. Corresponds to variant dbSNP:rs1136702Ensembl.1
Natural variantiVAR_056249133F → L. Corresponds to variant dbSNP:rs1059488Ensembl.1
Natural variantiVAR_056250151N → K. Corresponds to variant dbSNP:rs1059509Ensembl.1
Natural variantiVAR_056251166I → TCombined sourcesCorresponds to variant dbSNP:rs1059516Ensembl.1
Natural variantiVAR_056252169R → H. Corresponds to variant dbSNP:rs1059520Ensembl.1
Natural variantiVAR_016724180R → L in allele A*01:06. 1 PublicationCorresponds to variant dbSNP:rs9260156Ensembl.1
Natural variantiVAR_016725182V → A in allele A*01:06. 1 PublicationCorresponds to variant dbSNP:rs9260157Ensembl.1
Natural variantiVAR_056253205R → H. Corresponds to variant dbSNP:rs17185861Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M24043 Genomic DNA Translation: AAA59652.1
X55710 Genomic DNA Translation: CAA39243.1
Z93949 Genomic DNA Translation: CAB07989.1
AJ278305 Genomic DNA Translation: CAB93537.1
BC003069 mRNA Translation: AAH03069.1
U07161 mRNA Translation: AAA80569.1
Y12469 Genomic DNA Translation: CAA73072.1
Y12470 Genomic DNA Translation: CAA73073.1
AH008863 Genomic DNA Translation: AAF19525.1
AH007762 Genomic DNA Translation: AAD33894.1
AH009407 Genomic DNA Translation: AAF73862.1
PIRiI38518
I61856
RefSeqiNP_001229687.1, NM_001242758.1
UniGeneiHs.181244
Hs.713441

Genome annotation databases

EnsembliENST00000431930; ENSP00000406366; ENSG00000229215
ENST00000443552; ENSP00000404678; ENSG00000224320
ENST00000549869; ENSP00000447635; ENSG00000224320
ENST00000552193; ENSP00000447614; ENSG00000229215
GeneIDi3105
KEGGihsa:3105

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry namei1A01_HUMAN
AccessioniPrimary (citable) accession number: P30443
Secondary accession number(s): O77964
, O78171, Q9MYA3, Q9TP25, Q9TQP5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: May 23, 2018
This is version 166 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

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