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Protein

Major allergen I polypeptide chain 1

Gene

CH1

Organism
Felis catus (Cat) (Felis silvestris catus)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Major allergen I polypeptide chain 1
Alternative name(s):
AG4
Allergen Cat-1
Allergen Fel d I-A
Short name:
Allergen FdI
Short name:
Allergen Fel dI
Allergen: Fel d 1-A
Gene namesi
Name:CH1
OrganismiFelis catus (Cat) (Felis silvestris catus)
Taxonomic identifieri9685 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraFeliformiaFelidaeFelinaeFelis
Proteomesi
  • UP000011712 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Allergenic propertiesi

Causes an allergic reaction in human. Binds to IgE. Major allergen produced by the domestic cat. Implicated as an asthma-inducing agent in human. This protein is sticky and easily adheres to walls, carpet, clothing, furniture and bedding.

Keywords - Diseasei

Allergen

Protein family/group databases

Allergomei3278. Fel d 1.0101.
345. Fel d 1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 221 PublicationAdd BLAST22
ChainiPRO_000003637023 – 92Major allergen I polypeptide chain 1Add BLAST70

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi25Interchain (with C-90 in chain 2)
Disulfide bondi66Interchain (with C-65 in chain 2)
Disulfide bondi92Interchain (with C-24 in chain 2)

Keywords - PTMi

Disulfide bond

Expressioni

Tissue specificityi

Saliva and sebaceous glands.

Interactioni

Subunit structurei

Heterotetramer composed of two non-covalently linked disulfide-linked heterodimer of chains 1 and 2.

Structurei

Secondary structure

192
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi26 – 37Combined sources12
Helixi40 – 50Combined sources11
Helixi54 – 70Combined sources17
Helixi73 – 87Combined sources15

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1PUOX-ray1.85A/B23-92[»]
1ZKRX-ray1.64A/B23-92[»]
2EJNX-ray1.64A/B23-92[»]
ProteinModelPortaliP30438.
SMRiP30438.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP30438.

Family & Domainsi

Sequence similaritiesi

Belongs to the secretoglobin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

HOVERGENiHBG051604.
InParanoidiP30438.

Family and domain databases

CDDicd00633. Secretoglobin. 1 hit.
InterProiIPR006178. Allergen_Fel_d_I_chain1.
IPR016126. Secretoglobin.
[Graphical view]
PfamiPF01099. Uteroglobin. 1 hit.
[Graphical view]
PRINTSiPR00827. FELALLERGEN.
SMARTiSM00096. UTG. 1 hit.
[Graphical view]
SUPFAMiSSF48201. SSF48201. 1 hit.
PROSITEiPS51311. SCGB. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P30438-1) [UniParc]FASTAAdd to basket
Also known as: Leader A, Major

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKGACVLVLL WAALLLISGG NCEICPAVKR DVDLFLTGTP DEYVEQVAQY
60 70 80 90
KALPVVLENA RILKNCVDAK MTEEDKENAL SVLDKIYTSP LC
Length:92
Mass (Da):10,086
Last modified:November 1, 1995 - v2
Checksum:i083145F55EE8AAB3
GO
Isoform 2 (identifier: P30438-2) [UniParc]FASTAAdd to basket
Also known as: Leader B, Minor

The sequence of this isoform differs from the canonical sequence as follows:
     1-21: MKGACVLVLLWAALLLISGGN → MLDAALPPCPTVAATAD

Show »
Length:88
Mass (Da):9,600
Checksum:iB378D6D99B547B57
GO

Sequence cautioni

The sequence CAA44343 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAA44344 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti5C → R in AAC37318 (PubMed:1946388).Curated1
Sequence conflicti18S → W in AAC37318 (PubMed:1946388).Curated1
Sequence conflicti82V → L in AAC41617 (PubMed:1946388).Curated1
Sequence conflicti82V → L in AAC37318 (PubMed:1946388).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti51K → N.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0156651 – 21MKGAC…ISGGN → MLDAALPPCPTVAATAD in isoform 2. CuratedAdd BLAST21

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M74952 mRNA. Translation: AAC37318.1.
M74953 mRNA. Translation: AAC41617.1.
X62477 Genomic DNA. Translation: CAA44344.1. Different initiation.
X62477 Genomic DNA. Translation: CAA44343.1. Different initiation.
PIRiA56413.
JC1136.
RefSeqiNP_001041618.1. NM_001048153.1.

Genome annotation databases

GeneIDi677877.
KEGGifca:677877.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M74952 mRNA. Translation: AAC37318.1.
M74953 mRNA. Translation: AAC41617.1.
X62477 Genomic DNA. Translation: CAA44344.1. Different initiation.
X62477 Genomic DNA. Translation: CAA44343.1. Different initiation.
PIRiA56413.
JC1136.
RefSeqiNP_001041618.1. NM_001048153.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1PUOX-ray1.85A/B23-92[»]
1ZKRX-ray1.64A/B23-92[»]
2EJNX-ray1.64A/B23-92[»]
ProteinModelPortaliP30438.
SMRiP30438.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

Allergomei3278. Fel d 1.0101.
345. Fel d 1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi677877.
KEGGifca:677877.

Phylogenomic databases

HOVERGENiHBG051604.
InParanoidiP30438.

Miscellaneous databases

EvolutionaryTraceiP30438.

Family and domain databases

CDDicd00633. Secretoglobin. 1 hit.
InterProiIPR006178. Allergen_Fel_d_I_chain1.
IPR016126. Secretoglobin.
[Graphical view]
PfamiPF01099. Uteroglobin. 1 hit.
[Graphical view]
PRINTSiPR00827. FELALLERGEN.
SMARTiSM00096. UTG. 1 hit.
[Graphical view]
SUPFAMiSSF48201. SSF48201. 1 hit.
PROSITEiPS51311. SCGB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFEL1A_FELCA
AccessioniPrimary (citable) accession number: P30438
Secondary accession number(s): P30439
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: November 1, 1995
Last modified: November 30, 2016
This is version 103 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Allergens
    Nomenclature of allergens and list of entries
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.