Reviewed, UniProtKB/Swiss-Prot P30432 (FUR2_DROME)

Names and origin

Protein names

Recommended name:
    Furin-like protease 2
      Short name=Furin-2
    EC=3.4.21.75

Gene names

Name:	Fur2
ORF Names:	CG18734

Organism

Drosophila melanogaster (Fruit fly) [Complete proteome]

Taxonomic identifier

7227 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length	1679 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Furin is likely to represent the ubiquitous endoprotease activity within constitutive secretory pathways and capable of cleavage at the RX(K/R)R consensus motif By similarity.
Catalytic activity	Release of mature proteins from their proproteins by cleavage of -Arg-Xaa-Yaa-Arg-|-Zaa- bonds, where Xaa can be any amino acid and Yaa is Arg or Lys. Releases albumin, complement component C3 and vWF from their respective precursors.
Subcellular location	Membrane; Single-pass membrane protein Potential.
Tissue specificity	Transient expression in a subset of central nervous system neurons during embryonic stages 12-13. Expression in developing tracheal tree from stage 13 to end of embryonic development.
Developmental stage	Expressed both maternally and zygotically.
Sequence similarities	Belongs to the peptidase S8 family. Furin subfamily.
Sequence caution	The sequence AAX33562.1 differs from that shown. Reason: Miscellaneous discrepancy. Intron retention.

Ontologies

Keywords
Cellular component	Membrane
Coding sequence diversity	Alternative splicing
Domain	Repeat Signal Transmembrane
Molecular function	Hydrolase Protease Serine protease
PTM	Cleavage on pair of basic residues Disulfide bond Glycoprotein Zymogen
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	protein amino acid phosphorylation Inferred from electronic annotation. Source: InterPro proteolysis Inferred from electronic annotation. Source: InterPro transmembrane receptor protein tyrosine kinase signaling pathway Inferred from electronic annotation. Source: InterPro
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ATP binding Inferred from electronic annotation. Source: InterPro protein binding Inferred from physical interaction. Source: IntAct serine-type endopeptidase activity Ref.1 Inferred from direct assay. Source: FlyBase transmembrane receptor protein tyrosine kinase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
	Q9W4G3	1	EBI-496684,EBI-162037
Dlc90F	Q94524	1	EBI-496684,EBI-158251

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform D (identifier: P30432-1)

Also known as: E; F; G;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform A (identifier: P30432-2)

Also known as: B; C;

The sequence of this isoform differs from the canonical sequence as follows:
     386-386: L → LVSK

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – ?		Potential
	Propeptide	? – 318		Potential		PRO_0000027024
	Chain	319 – 1679	1361	Furin-like protease 2		PRO_0000027025
Regions
	Transmembrane	1512 – 1532	21	Potential
	Topological domain	1533 – 1679	147	Cytoplasmic Potential
	Repeat	961 – 1006	46	1
	Repeat	1007 – 1056	50	2
	Repeat	1057 – 1103	47	3
	Repeat	1104 – 1152	49	4
	Repeat	1153 – 1204	52	5
	Repeat	1205 – 1253	49	6
	Repeat	1254 – 1298	45	7
	Repeat	1299 – 1345	47	8
	Repeat	1346 – 1392	47	9
	Repeat	1393 – 1443	51	10
	Region	961 – 1443	483	10 X tandem repeats, Cys-rich
Sites
	Active site	417	1	Charge relay system By similarity
	Active site	456	1	Charge relay system By similarity
	Active site	637	1	Charge relay system By similarity
Amino acid modifications
	Glycosylation	3	1	N-linked (GlcNAc...) Potential
	Glycosylation	109	1	N-linked (GlcNAc...) Potential
	Glycosylation	130	1	N-linked (GlcNAc...) Potential
	Glycosylation	205	1	N-linked (GlcNAc...) Potential
	Glycosylation	442	1	N-linked (GlcNAc...) Potential
	Glycosylation	480	1	N-linked (GlcNAc...) Potential
	Glycosylation	927	1	N-linked (GlcNAc...) Potential
	Glycosylation	1060	1	N-linked (GlcNAc...) Potential
	Glycosylation	1181	1	N-linked (GlcNAc...) Potential
	Glycosylation	1274	1	N-linked (GlcNAc...) Potential
	Glycosylation	1277	1	N-linked (GlcNAc...) Potential
	Glycosylation	1439	1	N-linked (GlcNAc...) Potential
	Disulfide bond	473 ↔ 629		By similarity
	Disulfide bond	565 ↔ 595		By similarity
	Disulfide bond	720 ↔ 748		By similarity
Natural variations
	Alternative sequence	386	1	L → LVSK in isoform A.		VSP_009365
Experimental info
	Sequence conflict	152 – 153	2	Missing in AAA28551. Ref.1
	Sequence conflict	177	1	V → F in AAA28551. Ref.1
	Sequence conflict	213	1	V → VDQL in AAA28551. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform D (E) (F) (G) [UniParc]. Last modified November 25, 2002. Version 2. Checksum: 3F9E749F0B021CF6	FASTA	1,679	183,370
	10 20 30 40 50 60 MSNTTRSSRV TIGRIGTTPQ ITDPWSSGLE KQRPSRCGGP KSLAEPTYRK IGRRKMMLHM 70 80 90 100 110 120 RVHDPGTTVT QRAKETATAK LNRIYLCTFN RMAQSCIYFV LFLVILSPNT SCALRSSAGE 130 140 150 160 170 180 TQNYVGILSN DSATTTYDVS SLHSSRRTNP PSSSSSSSSN VDVDYRNDRE LHKVDLVGLG 190 200 210 220 230 240 GERAGQAETI SGGKYDYNYE NTHTNASAKD EIVERQSNSL DFDGVDMFGA FSIPEEAIYT 250 260 270 280 290 300 NEFAVNIPAG KQMADVIATK HGFINRGQIG SLDNYYLFQH HHVSKRSLRS SRKHQGALKS 310 320 330 340 350 360 ENEVKWMQQQ HEKVRRKRDG PYQDLPTYSP YNLLRQHGGY VVDPNPHLSF SPESISLASH 370 380 390 400 410 420 SQRMEYRDVS SHFIFPDPLF KEQWYLNGGA KDGLDMNVGP AWQKGYTGKG VVVSILDDGI 430 440 450 460 470 480 QTNHPDLAQN YDPEASFDIN GNDSDPTPQD NGDNKHGTRC AGEVAAVAFN NFCGVGVAYN 490 500 510 520 530 540 ASIGGVRMLD GKVNDVVEAQ ALSLNPSHID IYSASWGPED DGSTVDGPGP LARRAFIYGV 550 560 570 580 590 600 TSGRQGKGSI FVWASGNGGR YTDSCNCDGY TNSIFTLSIS SATQAGFKPW YLEECSSTLA 610 620 630 640 650 660 TTYSSGTPGH DKSVATVDMD GSLRPDHICT VEHTGTSASA PLAAGICALA LEANPELTWR 670 680 690 700 710 720 DMQYLVVYTS RPAPLEKENG WTLNGVKRKY SHKFGYGLMD AGAMVSLAEQ WTSVPPQHIC 730 740 750 760 770 780 KSRENNEDRK IDGAYGSTLS THMDVNGCAG TINEVRYLEH VQCRITLRFF PRGNLRILLT 790 800 810 820 830 840 SPMGTTSTLL FERPRDIVKS NFDDWPFLSV HFWGEKAEGR WTLQVINGGR RRVNQPGILS 850 860 870 880 890 900 KWQLIFYGTS TQPMRLKSEL LNSSPQLRSP SSSNPFLFPS ASNIGQPANE GGNFNTDSFA 910 920 930 940 950 960 SYLNYQNIFS SAGSDPEPAT ATLDGQNVTA AIAGGSSAES LGFTASAAQL VAAPETRDGD 970 980 990 1000 1010 1020 KKILHSCDAE CDSSGCYGRG PTQCVACSHY RLDNTCVSRC PPRSFPNQVG ICWPCHDTCE 1030 1040 1050 1060 1070 1080 TCAGAGPDSC LTCAPAHLHV IDLAVCLQFC PDGYFENSRN RTCVPCEPNC ASCQDHPEYC 1090 1100 1110 1120 1130 1140 TSCDHHLVMH EHKCYSACPL DTYETEDNKC AFCHSTCATC NGPTDQDCIT CRSSRYAWQN 1150 1160 1170 1180 1190 1200 KCLISCPDGF YADKKRLECM PCQEGCKTCT SNGVCSECLQ NWTLNKRDKC IVSGSEGCSE 1210 1220 1230 1240 1250 1260 SEFYSQVEGQ CRPCHASCGS CNGPADTSCT SCPPNRLLEQ SRCVSGCREG FFVEAGSLCS 1270 1280 1290 1300 1310 1320 PCLHTCSQCV SRTNCSNCSK GLELQNGECR TTCADGYYSD RGICAKCYLS CHTCSGPRRN 1330 1340 1350 1360 1370 1380 QCVQCPAGWQ LAAGECHPEC PEGFYKSDFG CQKCHHYCKT CNDAGPLACT SCPPHSMLDG 1390 1400 1410 1420 1430 1440 GLCMECLSSQ YYDTTSATCK TCHDSCRSCF GPGQFSCKGC VPPLHLDQLN SQCVSCCQNQ 1450 1460 1470 1480 1490 1500 TLAEKTSSAA CCNCDGETGE CKATSTGGKR RTVVGSGSAY KSSESKHGSF ENDGNAREFV 1510 1520 1530 1540 1550 1560 LRLDSPLTAI TAIAVAICLL IITIFSIIFA VLQRNSNHVS RNSVRYRKIA NTSSGRRKNL 1570 1580 1590 1600 1610 1620 SAKPTSDARF IFNIGEDDDT DGDNSDDELD GNVGTDINNR IVYDRKGNDH GHEFYIESTN 1630 1640 1650 1660 1670 DIDAIEFHCN GAGAQKAETQ LQRCNANGDD DDILHYDRHT NAERKNHPSS TTSRTNIRS
	Isoform A (B) (C). Checksum: F0BC981646F1C49F	FASTA	1,682	183,684
	10 20 30 40 50 60 MSNTTRSSRV TIGRIGTTPQ ITDPWSSGLE KQRPSRCGGP KSLAEPTYRK IGRRKMMLHM 70 80 90 100 110 120 RVHDPGTTVT QRAKETATAK LNRIYLCTFN RMAQSCIYFV LFLVILSPNT SCALRSSAGE 130 140 150 160 170 180 TQNYVGILSN DSATTTYDVS SLHSSRRTNP PSSSSSSSSN VDVDYRNDRE LHKVDLVGLG 190 200 210 220 230 240 GERAGQAETI SGGKYDYNYE NTHTNASAKD EIVERQSNSL DFDGVDMFGA FSIPEEAIYT 250 260 270 280 290 300 NEFAVNIPAG KQMADVIATK HGFINRGQIG SLDNYYLFQH HHVSKRSLRS SRKHQGALKS 310 320 330 340 350 360 ENEVKWMQQQ HEKVRRKRDG PYQDLPTYSP YNLLRQHGGY VVDPNPHLSF SPESISLASH 370 380 390 400 410 420 SQRMEYRDVS SHFIFPDPLF KEQWYLVSKN GGAKDGLDMN VGPAWQKGYT GKGVVVSILD 430 440 450 460 470 480 DGIQTNHPDL AQNYDPEASF DINGNDSDPT PQDNGDNKHG TRCAGEVAAV AFNNFCGVGV 490 500 510 520 530 540 AYNASIGGVR MLDGKVNDVV EAQALSLNPS HIDIYSASWG PEDDGSTVDG PGPLARRAFI 550 560 570 580 590 600 YGVTSGRQGK GSIFVWASGN GGRYTDSCNC DGYTNSIFTL SISSATQAGF KPWYLEECSS 610 620 630 640 650 660 TLATTYSSGT PGHDKSVATV DMDGSLRPDH ICTVEHTGTS ASAPLAAGIC ALALEANPEL 670 680 690 700 710 720 TWRDMQYLVV YTSRPAPLEK ENGWTLNGVK RKYSHKFGYG LMDAGAMVSL AEQWTSVPPQ 730 740 750 760 770 780 HICKSRENNE DRKIDGAYGS TLSTHMDVNG CAGTINEVRY LEHVQCRITL RFFPRGNLRI 790 800 810 820 830 840 LLTSPMGTTS TLLFERPRDI VKSNFDDWPF LSVHFWGEKA EGRWTLQVIN GGRRRVNQPG 850 860 870 880 890 900 ILSKWQLIFY GTSTQPMRLK SELLNSSPQL RSPSSSNPFL FPSASNIGQP ANEGGNFNTD 910 920 930 940 950 960 SFASYLNYQN IFSSAGSDPE PATATLDGQN VTAAIAGGSS AESLGFTASA AQLVAAPETR 970 980 990 1000 1010 1020 DGDKKILHSC DAECDSSGCY GRGPTQCVAC SHYRLDNTCV SRCPPRSFPN QVGICWPCHD 1030 1040 1050 1060 1070 1080 TCETCAGAGP DSCLTCAPAH LHVIDLAVCL QFCPDGYFEN SRNRTCVPCE PNCASCQDHP 1090 1100 1110 1120 1130 1140 EYCTSCDHHL VMHEHKCYSA CPLDTYETED NKCAFCHSTC ATCNGPTDQD CITCRSSRYA 1150 1160 1170 1180 1190 1200 WQNKCLISCP DGFYADKKRL ECMPCQEGCK TCTSNGVCSE CLQNWTLNKR DKCIVSGSEG 1210 1220 1230 1240 1250 1260 CSESEFYSQV EGQCRPCHAS CGSCNGPADT SCTSCPPNRL LEQSRCVSGC REGFFVEAGS 1270 1280 1290 1300 1310 1320 LCSPCLHTCS QCVSRTNCSN CSKGLELQNG ECRTTCADGY YSDRGICAKC YLSCHTCSGP 1330 1340 1350 1360 1370 1380 RRNQCVQCPA GWQLAAGECH PECPEGFYKS DFGCQKCHHY CKTCNDAGPL ACTSCPPHSM 1390 1400 1410 1420 1430 1440 LDGGLCMECL SSQYYDTTSA TCKTCHDSCR SCFGPGQFSC KGCVPPLHLD QLNSQCVSCC 1450 1460 1470 1480 1490 1500 QNQTLAEKTS SAACCNCDGE TGECKATSTG GKRRTVVGSG SAYKSSESKH GSFENDGNAR 1510 1520 1530 1540 1550 1560 EFVLRLDSPL TAITAIAVAI CLLIITIFSI IFAVLQRNSN HVSRNSVRYR KIANTSSGRR 1570 1580 1590 1600 1610 1620 KNLSAKPTSD ARFIFNIGED DDTDGDNSDD ELDGNVGTDI NNRIVYDRKG NDHGHEFYIE 1630 1640 1650 1660 1670 1680 STNDIDAIEF HCNGAGAQKA ETQLQRCNAN GDDDDILHYD RHTNAERKNH PSSTTSRTNI RS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and functional expression of Dfurin2, a subtilisin-like proprotein processing enzyme of Drosophila melanogaster with multiple repeats of a cysteine motif." Roebroek A.J.M., Creemers J.W.M., Pauli I.G.L., Kurzik-Dumke U., Rentrop M., Gateff E.A.F., Leunissen J.A.M., van de Ven W.J.M. J. Biol. Chem. 267:17208-17215(1992) [PubMed: 1512259] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM D). Strain: Iso-1, Oregon-R and Tuebingen. Tissue: Embryo.
[2]	"The Dfur2 gene of Drosophila melanogaster: genetic organization, expression during embryogenesis, and pro-protein processing activity of its translational product Dfurin2." Roebroek A.J.M., Ayoubi T.A.Y., Creemers J.W.M., Pauli I.G.L., van de Ven W.J.M. DNA Cell Biol. 14:223-234(1995) [PubMed: 7880443] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: Iso-1.
[3]	"The genome sequence of Drosophila melanogaster." Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C. Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Berkeley.
[4]	"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review." Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E. Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract] Cited for: GENOME REANNOTATION, ALTERNATIVE SPLICING.
[5]	Stapleton M., Carlson J.W., Chavez C., Frise E., George R.A., Pacleb J.M., Park S., Wan K.H., Yu C., Rubin G.M., Celniker S.E. Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM D). Strain: Berkeley. Tissue: Embryo.
[6]	"A Drosophila full-length cDNA resource." Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A., Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M., Celniker S.E. Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002) [PubMed: 12537569] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 305-1679 (ISOFORM A). Strain: Berkeley. Tissue: Embryo.

Cross-references

Sequence databases
EMBLGenBankDDBJ	M94375 mRNA. Translation: AAA28551.1. L33831 Genomic DNA. Translation: AAA69860.1. AE014298 Genomic DNA. Translation: AAF48598.2. AE014298 Genomic DNA. Translation: AAF48599.2. AE014298 Genomic DNA. Translation: AAN09399.1. AE014298 Genomic DNA. Translation: AAN09400.1. AE014298 Genomic DNA. Translation: AAN09401.1. AE014298 Genomic DNA. Translation: AAN09402.1. AE014298 Genomic DNA. Translation: AAS65387.1. BT021414 mRNA. Translation: AAX33562.1. Sequence problems. AY070553 mRNA. Translation: AAL48024.1. Different initiation.
PIR	A43434.
RefSeq	NP_523368.2. NP_727963.1. NP_727964.1. NP_727965.1. NP_727966.1. NP_727967.1. NP_996486.1.
UniGene	Dm.6383
3D structure databases
HSSP	HSSP built from PDB template 1P8J based on UniProtKB P23188.
ModBase	Search...
Protein-protein interaction databases
IntAct	P30432. 17 interactions.
Protein family/group databases
MEROPS	S08.049.
Genome annotation databases
Ensembl	FBgn0004598. Drosophila melanogaster. [Contig view]
GeneID	32604.
KEGG	dme:Dmel_CG18734.
Organism-specific databases
FlyBase	FBgn0004598. Fur2.
Phylogenomic databases
OMA	P30432. DDGIQTN.
Enzyme and pathway databases
BioCyc	DMEL-XXX-02:DMEL-XXX-02-002159-MON. DMEL-XXX-02:DMEL-XXX-02-002161-MON. DMEL-XXX-02:DMEL-XXX-02-002163-MON.
BRENDA	3.4.21.75. 48.
Gene expression databases
ArrayExpress	P30432.
GermOnline	CG18734. Drosophila melanogaster.
Family and domain databases
InterPro	IPR006210. EGF-like. IPR006211. Furin-like. IPR006212. Furin_repeat. IPR000209. Pept_S8_S53. IPR015500. Peptidase_S8_subtilisin-rel. IPR002884. PrprotnconvertsP. [Graphical view]
Gene3D	G3DSA:3.40.50.200. Pept_S8_S53. 1 hit.
PANTHER	PTHR10795. SubtilSerProt. 1 hit.
Pfam	PF00757. Furin-like. 1 hit. PF01483. P_proprotein. 1 hit. PF00082. Peptidase_S8. 1 hit. [Graphical view]
PRINTS	PR00723. SUBTILISIN.
ProDom	PD000717. PrprotnconvertsP. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00181. EGF. 1 hit. SM00261. FU. 10 hits. [Graphical view]
PROSITE	PS00136. SUBTILASE_ASP. 1 hit. PS00137. SUBTILASE_HIS. 1 hit. PS00138. SUBTILASE_SER. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	779394.

Entry information

Entry name

FUR2_DROME

Accession

Primary (citable) accession number: P30432
Secondary accession number(s): A4V4M0 , A4V4M2, Q24301, Q5BI10, Q8SZS2

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 1, 1993
Last sequence update:	November 25, 2002
Last modified:	June 16, 2009
This is version 96 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Drosophila annotation project