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Protein

Plectin

Gene

Plec

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Interlinks intermediate filaments with microtubules and microfilaments and anchors intermediate filaments to desmosomes or hemidesmosomes. May be involved not only in the cross-linking and stabilization of cytoskeletal intermediate filaments network, but also in the regulation of their dynamics.

GO - Molecular functioni

  • ankyrin binding Source: BHF-UCL
  • cytoskeletal protein binding Source: RGD
  • protein N-terminus binding Source: RGD
  • structural constituent of cytoskeleton Source: RGD

GO - Biological processi

  • epithelial cell differentiation Source: RGD
  • female pregnancy Source: RGD
  • hemidesmosome assembly Source: UniProtKB
  • response to nutrient Source: RGD
Complete GO annotation...

Keywords - Ligandi

Actin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Plectin
Short name:
PCN
Short name:
PLTN
Alternative name(s):
Plectin-1
Gene namesi
Name:Plec
Synonyms:Plec1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi621649. Plec.

Subcellular locationi

GO - Cellular componenti

  • apical plasma membrane Source: RGD
  • basal plasma membrane Source: RGD
  • costamere Source: BHF-UCL
  • cytoskeleton Source: UniProtKB-SubCell
  • hemidesmosome Source: UniProtKB
  • perinuclear region of cytoplasm Source: RGD
  • sarcolemma Source: BHF-UCL
  • sarcoplasm Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 46874687PlectinPRO_0000078137Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei723 – 7231PhosphoserineCombined sources
Modified residuei818 – 8181PhosphothreonineBy similarity
Modified residuei1050 – 10501PhosphoserineCombined sources
Modified residuei1438 – 14381PhosphoserineCombined sources
Modified residuei1724 – 17241PhosphoserineBy similarity
Modified residuei1728 – 17281N6-acetyllysineBy similarity
Modified residuei2634 – 26341PhosphoserineBy similarity
Modified residuei2639 – 26391N6-acetyllysineBy similarity
Modified residuei2777 – 27771PhosphoserineCombined sources
Modified residuei2784 – 27841PhosphotyrosineBy similarity
Modified residuei2805 – 28051PhosphoserineBy similarity
Modified residuei2889 – 28891PhosphothreonineBy similarity
Modified residuei3036 – 30361PhosphotyrosineBy similarity
Modified residuei3056 – 30561N6-acetyllysineBy similarity
Modified residuei3094 – 30941N6-acetyllysineBy similarity
Modified residuei3365 – 33651PhosphotyrosineBy similarity
Modified residuei3423 – 34231N6-acetyllysineBy similarity
Modified residuei3583 – 35831PhosphoserineCombined sources
Modified residuei3788 – 37881PhosphothreonineBy similarity
Modified residuei3793 – 37931PhosphotyrosineBy similarity
Modified residuei4033 – 40331PhosphothreonineCombined sources
Modified residuei4057 – 40571PhosphoserineBy similarity
Modified residuei4385 – 43851PhosphoserineBy similarity
Modified residuei4387 – 43871PhosphoserineCombined sources
Modified residuei4388 – 43881PhosphoserineCombined sources
Modified residuei4389 – 43891PhosphoserineCombined sources
Modified residuei4392 – 43921PhosphoserineCombined sources
Modified residuei4393 – 43931PhosphoserineBy similarity
Modified residuei4394 – 43941PhosphoserineCombined sources
Modified residuei4395 – 43951PhosphoserineBy similarity
Modified residuei4396 – 43961PhosphotyrosineBy similarity
Modified residuei4399 – 43991PhosphoserineBy similarity
Modified residuei4409 – 44091PhosphoserineCombined sources
Modified residuei4414 – 44141PhosphothreonineBy similarity
Modified residuei4542 – 45421Phosphothreonine; by CDK1By similarity
Modified residuei4610 – 46101PhosphoserineBy similarity
Modified residuei4616 – 46161PhosphoserineCombined sources
Modified residuei4618 – 46181PhosphotyrosineBy similarity
Modified residuei4619 – 46191PhosphoserineBy similarity
Modified residuei4621 – 46211PhosphoserineBy similarity
Modified residuei4625 – 46251PhosphoserineBy similarity
Modified residuei4626 – 46261PhosphothreonineBy similarity
Modified residuei4629 – 46291PhosphoserineCombined sources
Modified residuei4645 – 46451PhosphoserineBy similarity
Modified residuei4678 – 46781PhosphoserineBy similarity
Isoform 2 (identifier: P30427-2)
Modified residuei21 – 211PhosphoserineCombined sourcesBy similarity
Modified residuei26 – 261PhosphotyrosineCombined sourcesBy similarity

Post-translational modificationi

Phosphorylated by CDK1; regulates dissociation from intermediate filaments during mitosis. Isoform 2 is phosphorylated on Ser-21 and Tyr-26 (By similarity).By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiP30427.
PRIDEiP30427.

PTM databases

iPTMnetiP30427.
PhosphoSiteiP30427.

Expressioni

Tissue specificityi

Widely expressed with highest expression in skeletal muscle and lowest in thymus.1 Publication

Interactioni

Subunit structurei

Homodimer or homotetramer (By similarity). Interacts (via actin-binding domain) with SYNE3. Interacts (via CH 1 domain) with VIM (via rod region). Interacts (via N-terminus) with DST isoform 2 (via N-terminus). Interacts with FER. Interacts with TOR1A (By similarity). Interacts with ANK3 (PubMed:21223964). Identified in complexes that contain VIM, EZR, AHNAK, BFSP1, BFSP2, ANK2, PLEC, PRX and spectrin (By similarity).By similarity1 Publication

GO - Molecular functioni

  • ankyrin binding Source: BHF-UCL
  • cytoskeletal protein binding Source: RGD
  • protein N-terminus binding Source: RGD

Protein-protein interaction databases

IntActiP30427. 2 interactions.
STRINGi10116.ENSRNOP00000040018.

Structurei

3D structure databases

ProteinModelPortaliP30427.
SMRiP30427. Positions 181-409, 419-636, 2785-3026, 3444-3684, 4024-4263, 4415-4608.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini181 – 406226Actin-bindingAdd
BLAST
Domaini185 – 288104CH 1PROSITE-ProRule annotationAdd
BLAST
Domaini301 – 403103CH 2PROSITE-ProRule annotationAdd
BLAST
Repeati648 – 72275Spectrin 1Add
BLAST
Repeati743 – 82785Spectrin 2Add
BLAST
Repeati840 – 93394Spectrin 3Add
BLAST
Repeati1318 – 1418101Spectrin 4Add
BLAST
Repeati2791 – 282838Plectin 1Add
BLAST
Repeati2829 – 286638Plectin 2Add
BLAST
Repeati2867 – 290438Plectin 3Add
BLAST
Repeati2905 – 294238Plectin 4Add
BLAST
Repeati2943 – 298038Plectin 5Add
BLAST
Repeati2984 – 301835Plectin 6Add
BLAST
Repeati3119 – 315638Plectin 7Add
BLAST
Repeati3157 – 319438Plectin 8Add
BLAST
Repeati3195 – 323238Plectin 9Add
BLAST
Repeati3233 – 327038Plectin 10Add
BLAST
Repeati3271 – 330838Plectin 11Add
BLAST
Repeati3311 – 334636Plectin 12Add
BLAST
Repeati3488 – 352538Plectin 13Add
BLAST
Repeati3526 – 356338Plectin 14Add
BLAST
Repeati3564 – 360138Plectin 15Add
BLAST
Repeati3602 – 363938Plectin 16Add
BLAST
Repeati3643 – 367735Plectin 17Add
BLAST
Repeati3823 – 386038Plectin 18Add
BLAST
Repeati3861 – 389838Plectin 19Add
BLAST
Repeati3899 – 393638Plectin 20Add
BLAST
Repeati3937 – 397438Plectin 21Add
BLAST
Repeati3978 – 401134Plectin 22Add
BLAST
Repeati4066 – 410338Plectin 23Add
BLAST
Repeati4104 – 414138Plectin 24Add
BLAST
Repeati4142 – 417938Plectin 25Add
BLAST
Repeati4180 – 421738Plectin 26Add
BLAST
Repeati4221 – 425535Plectin 27Add
BLAST
Repeati4268 – 430841Plectin 28Add
BLAST
Repeati4411 – 444838Plectin 29Add
BLAST
Repeati4449 – 448638Plectin 30Add
BLAST
Repeati4487 – 452438Plectin 31Add
BLAST
Repeati4525 – 456238Plectin 32Add
BLAST
Repeati4563 – 460038Plectin 33Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 14731473Globular 1Add
BLAST
Regioni1474 – 27581285Central fibrous rod domainAdd
BLAST
Regioni2759 – 46871929Globular 2Add
BLAST
Regioni4253 – 430351Binding to intermediate filamentsAdd
BLAST
Regioni4628 – 4643164 X 4 AA tandem repeats of G-S-R-XAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili1472 – 1692221Sequence analysisAdd
BLAST
Coiled coili1724 – 27601037Sequence analysisAdd
BLAST

Domaini

The N-terminus interacts with actin, the C-terminus with vimentin, desmin, GFAP, cytokeratins, lamin B; whereas both the N- and the C-terminus can bind integrin beta-4.

Sequence similaritiesi

Belongs to the plakin or cytolinker family.Curated
Contains 1 actin-binding domain.Curated
Contains 2 CH (calponin-homology) domains.PROSITE-ProRule annotation
Contains 33 plectin repeats.Curated
Contains 4 spectrin repeats.Curated

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

eggNOGiKOG0516. Eukaryota.
COG5069. LUCA.
HOVERGENiHBG053616.
InParanoidiP30427.
PhylomeDBiP30427.

Family and domain databases

Gene3Di1.10.418.10. 2 hits.
3.90.1290.10. 7 hits.
InterProiIPR001589. Actinin_actin-bd_CS.
IPR001715. CH-domain.
IPR030269. Plectin.
IPR001101. Plectin_repeat.
IPR005326. S10_plectin_N.
IPR018159. Spectrin/alpha-actinin.
[Graphical view]
PANTHERiPTHR11915:SF247. PTHR11915:SF247. 4 hits.
PfamiPF00307. CH. 2 hits.
PF00681. Plectin. 18 hits.
PF03501. S10_plectin. 1 hit.
[Graphical view]
SMARTiSM00033. CH. 2 hits.
SM00250. PLEC. 34 hits.
SM00150. SPEC. 6 hits.
[Graphical view]
SUPFAMiSSF47576. SSF47576. 1 hit.
SSF75399. SSF75399. 8 hits.
PROSITEiPS00020. ACTININ_2. 1 hit.
PS50021. CH. 2 hits.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P30427-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVAGMLMPLD QLRAIYEVLF REGVMVAKKD RRPRSLHPHV PGVTNLQVMR
60 70 80 90 100
AMTSLKARGL VRETFAWCHF YWYLTNEGID HLRQYLHLPP EIVPASLQRV
110 120 130 140 150
RRPVAMVMPA RRRSPHVQTM QGPLGCPPKR GPLPAEDPAR EERQVYRRKE
160 170 180 190 200
REEGAPETPV VSATIVGTLA RPGPEPTPAT DERDRVQKKT STKWVNKHLI
210 220 230 240 250
KAQRHISDLY EDLRDGHNLI SLLEVLSGDS LPREKGRMRF HKLQNVQIAL
260 270 280 290 300
DYLRHRQVKL VNIRNDDIAD GNPKLTLGLI WTIILHFKIS DIQVSGQSED
310 320 330 340 350
MTAKEKLLLW SQRMVEGYQG LRCDNFTTSW RDGRLFNAII HRHKPMLIDM
360 370 380 390 400
NKVYRQTNLE NLDQAFSVAE RDLGVTRLLD PEDVDVPQPD EKSIITYVSS
410 420 430 440 450
LYDAMPRVPG AQDGVRANEL QLRWQEYREL VLLLLQWIRH HTAAFEERKF
460 470 480 490 500
PSSFEEIEIL WCQFLKFKET ELPAKEADKN RSKGIYQSLE GAVQAGQLKI
510 520 530 540 550
PPGYHPLDVE KEWGKLHVAI LEREKQLRSE FERLECLQRI VSKLQMEAGL
560 570 580 590 600
CEEQLYQADS LLQSDIRLLA SGKAAQRAGE VERDLDKADG MIRLLFNDVQ
610 620 630 640 650
TLKDGRHPQG EQMYRRVYRL HERLVAIRTE YNLRLKAGVG APVTQVTLQS
660 670 680 690 700
TQRRPELEDS TLRYLHDLLA WVEENQRRID GAEWGVDLPS VEAQLGSHRG
710 720 730 740 750
MHQSIEEFRA KIERARNDES QLSPATRGAY RDCLGRLDLQ YAKLLNSSKA
760 770 780 790 800
RLRSLESLHG FVAAATKELM WLNEKEEEEV GFDWSDRNTN MAAKKESYSA
810 820 830 840 850
LMRELEMKEK KIKEIQNTGD RLLREDHPAR PTVESFQAAL QTQWSWMLQL
860 870 880 890 900
CCCIEAHLKE NTAYFQFFSD VREAEEQLQK LQETLRRKYS CDRSITVTRL
910 920 930 940 950
EDLLQDAQDE KEQLNEYKGH LSGLAKRAKA IVQLKPRNPA HPVRGHVPLL
960 970 980 990 1000
AVCDYKQVEV TVHKGDQCQL VGPAQPFHWK VLSSSGSEAA VPSVCFLVPP
1010 1020 1030 1040 1050
PNQEAQEAVA RLEAQHQALV TLWHQLHVDM KSLLAWQSLN RDIQLIRSWS
1060 1070 1080 1090 1100
LVTFRTLKPE EQRQALRNLE LHYQAFLRDS QDAGGFGPED RLVAEREYGS
1110 1120 1130 1140 1150
CSRHYQQLLQ SLEQGEQEES RCQRCISELK DIRLQLEACE TRTVHRLRLP
1160 1170 1180 1190 1200
LDKDPARECA QRIAEQQKAQ AEVEGLGKGV ARLSAEAEKV LALPEPSPAA
1210 1220 1230 1240 1250
PTLRSELELT LGKLEQVRSL SAIYLEKLKT ISLVIRSTQG AEEVLKTHEE
1260 1270 1280 1290 1300
HLKEAQAVPA TLQELEVTKA SLKKLRAQAE AQQPVFNTLR DELRGAQEVG
1310 1320 1330 1340 1350
ERLQQRHGER DVEVERWRER VTQLLERWQA VLAQTDVRQR ELEQLGRQLR
1360 1370 1380 1390 1400
YYRESADPLS SWLQDAKSRQ EQIQAVPIAN SQAAREQLRQ EKALLEEIER
1410 1420 1430 1440 1450
HGEKVEECQK FAKQYINAIK DYELQLITYK AQLEPVASPA KKPKVQSGSE
1460 1470 1480 1490 1500
SVIQEYVDLR TRYSELTTLT SQYIKFISET LRRMEEEERL AEQQRAEERE
1510 1520 1530 1540 1550
RLAEVEAALE KQRQLAEAHA QAKAQAELEA RELQRRMQEE VTRREEAAVD
1560 1570 1580 1590 1600
AQQQKRSIQE ELQHLRQSSE AEIQAKAQQV EAAERSRMRI EEEIRVVRLQ
1610 1620 1630 1640 1650
LETTERQRGG AEDELQALRA RAEEAEAQKR QAQEEAERLR RQVQDESQRK
1660 1670 1680 1690 1700
RQAEAELALR VKAEAEAARE KQRALQALDE LKLQAEEAER WLCQAEAERA
1710 1720 1730 1740 1750
RQVQVALETA QRSAEVELQS KRPSFAEKTA QLERTLQEEH VTVTQLREEA
1760 1770 1780 1790 1800
ERRAQQQAEA ERAREEAERE LERWQLKANE ALRLRLQAEE VAQQKSLAQA
1810 1820 1830 1840 1850
DAEKQKEEAE REARRRGKAE EQAVRQRELA EQELEKQRQL TEGTAQQRLA
1860 1870 1880 1890 1900
AEQELIRLRA ETEQGEHQRQ LLEEELARLQ HEATAATQKR QELEAELAKV
1910 1920 1930 1940 1950
RAEMEVLLAS KARAEEESRS TSEKSKQRLE AEAGRFRELA EEAARLRALA
1960 1970 1980 1990 2000
EEARRHRELA EEDAARQRAE ADGVLTEKLA AISEATRLKT EAEIALKEKE
2010 2020 2030 2040 2050
AENERLRRLA EDEAFQRRRL EEQAAQHKAD IEERLAQLRK ASESELERQK
2060 2070 2080 2090 2100
GLVEDTLRQR RQVEEEIMAL KASFEKAAAG KAELELELGR IRSNAEDTMR
2110 2120 2130 2140 2150
SKELAEQEAA RQRQLAAEEE QRRREAEERV QRSLAAEEEA ARQRKVALEE
2160 2170 2180 2190 2200
VERLKAKVEE ARRLRERAEQ ESARQLQLAQ EAAQKRLQAE EKAHAFVVQQ
2210 2220 2230 2240 2250
REEELQQTLQ QEQNMLERLR SEAEAARRAA EEAEEAREQA EREAAQSRKQ
2260 2270 2280 2290 2300
VEEAERLKQS AEEQAQAQAQ AQAAAEKLRK EAEQEAARRA QAEQAALKQK
2310 2320 2330 2340 2350
QAADAEMEKH KKFAEQTLRQ KAQVEQELTT LRLQLEETDH QKSILDEELQ
2360 2370 2380 2390 2400
RLKAEVTEAA RQRSQVEEEL FSVRVQMEEL GKLKARIEAE NRALILRDKD
2410 2420 2430 2440 2450
NTQRFLEEEA EKMKQVAEEA ARLSVAAQEA ARLRQLAEED LAQQRALAEK
2460 2470 2480 2490 2500
MLKEKMQAVQ EATRLKAEAE LLQQQKELAQ EQARRLQADK EQMAQQLVEE
2510 2520 2530 2540 2550
TQGFQRTLEA ERQRQLEMSA EAERLKLRMA EMSRAQARAE EDAQRFRKQA
2560 2570 2580 2590 2600
EEIGEKLHRT ELATQEKVTL VQTLEIQRQQ SDQDAERLRE AIAELEREKE
2610 2620 2630 2640 2650
KLKQEAKLLQ LKSEEMQTVQ QEQILQETQA LQKSFLSEKD SLLQRERFIE
2660 2670 2680 2690 2700
QEKAKLEQLF QDEVAKAKQL QEEQQRQQQQ MEQEKQELVA SMEEARRRQR
2710 2720 2730 2740 2750
EAEEGVRRKQ EELQRLEQQR QQQEKLLAEE NQRLRERLQR LEEEHRAALA
2760 2770 2780 2790 2800
HSEEIATSQA AATKALPNGR DALDGPSMEA EPEYTFEGLR QKVPAQQLQE
2810 2820 2830 2840 2850
AGILSMEELQ RLTQGHTTVA ELTQREDVRH YLKGGSSIAG LLLKPTNEKL
2860 2870 2880 2890 2900
SVYTALQRQL LSPGTALILL EAQAASGFLL DPVRNRRLTV NEAVKEGVVG
2910 2920 2930 2940 2950
PELHHKLLSA ERAVTGYKDP YTGEQISLFQ AMKKDLIVRD HGIRLLEAQI
2960 2970 2980 2990 3000
ATGGIIDPVH SHRVPVDVAY QRGYFDEEMN RVLADPSDDT KGFFDPNTHE
3010 3020 3030 3040 3050
NLTYLQLLER CVEDPETGLR LLPLTDKAAK GGELVYTDTE ARDVFEKATV
3060 3070 3080 3090 3100
SAPFGKFQGK TVTIWEIINS EYFTAEQRRD LLRQFRTGRI TVEKIIKIVI
3110 3120 3130 3140 3150
TVVEEHERKG QLCFEGLRAL VPAAELLDSG VISHEVYQQL QRGERSVREV
3160 3170 3180 3190 3200
AEADEVRQAL RGTSVIAGVW LEEAGQKLSI YEALRRDLLQ PEVAVALLEA
3210 3220 3230 3240 3250
QAGTGHIIDP ATSARLTVDE AVRAGLVGPE MHEKLLSAEK AVTGYRDPYS
3260 3270 3280 3290 3300
GQSVSLFQAL KKGLIPREQG LRLLDAQLST GGIVDPSKSH RVPLDVAYAR
3310 3320 3330 3340 3350
GYLDKETNRA LTSPRDDARV YLDPSTREPV TYSQLQQRCR SDQLTGLSLL
3360 3370 3380 3390 3400
PLSEKAVRAR QEEVYSELQA RETLEKAKVE VPVGGFKGRA LTVWELISSE
3410 3420 3430 3440 3450
YFTEEQRQEL LRQFRTGKVT VEKVIKILIT IVEEVETQRQ ERLSFSGLRA
3460 3470 3480 3490 3500
PVPASELLAS KILSRTQFEQ LKDGKTSVKD LSEVGSVRTL LQGSGCLAGI
3510 3520 3530 3540 3550
YLEDSKEKVT IYEAMRRGLL RASTATLLLE AQAATGFLVD PVRNQRLYVH
3560 3570 3580 3590 3600
EAVKAGVVGP ELHEKLLSAE KAVTGYKDPY SGSTISLFQA MKKGLVLRDH
3610 3620 3630 3640 3650
AIRLLEAQIA TGGIIDPVHS HRLPVDVAYQ RGYFDEEMNR VLADPSDDTK
3660 3670 3680 3690 3700
GFFDPNTHEN LTYLQLLERC VEDPETGLRL LPLRGAEKTE VVETTQVYTE
3710 3720 3730 3740 3750
EETRRAFEET QIDIPGGGSH GGSSMSLWEV MQSDMIPEDQ RARLMADFQA
3760 3770 3780 3790 3800
GRVTKERMII IIIEIIEKTE IIRQQNLASY DYVRRRLTAE DLYEARIISL
3810 3820 3830 3840 3850
ETYNLFREGT KSLREVLEME SAWRYLYGTG SVAGVYLPGS RQTLTIYQAL
3860 3870 3880 3890 3900
KKGLLSAEVA RLLLEAQAAT GFLLDPVKGE RLTVDEAVRK GLVGPELHDR
3910 3920 3930 3940 3950
LLSAERAVTG YRDPYTEQPI SLFQAMKKEL IPAEEALRLL DAQLATGGIV
3960 3970 3980 3990 4000
DPRLGFHLPL EVAYQRGYLN KDTHDQLSEP SEVRSYVDPS TDERLSYTQL
4010 4020 4030 4040 4050
LKRCRRDDNS GQMLLPLSDA RKLTFRGLRK QITVEELVRS QVMDEATALQ
4060 4070 4080 4090 4100
LQEGLTSIEE VTKNLQKFLE GTSCIAGVFV DATKERLSVY QAMKKGIIRP
4110 4120 4130 4140 4150
GTAFELLEAQ AATGYVIDPI KGLKLTVEEA VRMGIVGPEF KDKLLSAERA
4160 4170 4180 4190 4200
VTGYKDPYSG KLISLFQAMK KGLILKDHGI RLLEAQIATG GIIDPEESHR
4210 4220 4230 4240 4250
LPVEVAYKRG LFDEEMNEIL TDPSDDTKGF FDPNTEENLT YLQLMERCIT
4260 4270 4280 4290 4300
DPQTGLCLLP LKEKKRERKT SSKSSVRKRR VVIVDPETGK EMSVYEAYRK
4310 4320 4330 4340 4350
GLIDHQTYLE LSEQECEWEE ITISSSDGVV KSMIIDRRSG RQYDIGDAIT
4360 4370 4380 4390 4400
KNLIDRSALD QYRAGTLSIT EFADMLSGNA GGFRSRSSSV GSSSSYPISS
4410 4420 4430 4440 4450
AVPRTQLASW SDPTEETGPV AGILDTETLE KVSITEAMHR NLVDNITGQR
4460 4470 4480 4490 4500
LLEAQACTGG IIDPSTGERF PVTEAVNKGL VDKIMVDRIN LAQKAFCGFE
4510 4520 4530 4540 4550
DPRTKTKMSA AQALKKGWLY YEAGQRFLEV QYLTGGLIEP DTPGRVSLDE
4560 4570 4580 4590 4600
ALQRGTVDAR TAQKLRDVSA YSKYLTCPKT KLKISYKDAL DRSMVEEGTG
4610 4620 4630 4640 4650
LRLLEAAAQS SKGYYSPYSV SGSGSTAGSR TGSRTGSRAG SRRGSFDATG
4660 4670 4680
SGFSMTFSSS SYSSSGYGRR YASGPSASLG GPESAVA
Length:4,687
Mass (Da):533,540
Last modified:October 1, 1996 - v2
Checksum:i9966CAF71B929751
GO
Isoform 2 (identifier: P30427-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-180: MVAGMLMPLD...RPGPEPTPAT → MSQQRLRVPE...AVLRASEGKK

Show »
Length:4,544
Mass (Da):517,248
Checksum:i97AEEC58023034A9
GO
Isoform 3 (identifier: P30427-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-180: MVAGMLMPLD...RPGPEPTPAT → MEPSGSLFPS...KGHRQAQDEQ

Show »
Length:4,544
Mass (Da):517,256
Checksum:i13FFBE5F79240532
GO
Isoform 4 (identifier: P30427-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-180: MVAGMLMPLD...RPGPEPTPAT → DVSNGSSGSP...PAERAVIRIA

Note: Incomplete sequence.
Show »
Length:4,558
Mass (Da):518,238
Checksum:i40B5E5371A74B56D
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 180180MVAGM…PTPAT → MSQQRLRVPEPEGLGSKRTS SEDNLYLAVLRASEGKK in isoform 2. CuratedVSP_005050Add
BLAST
Alternative sequencei1 – 180180MVAGM…PTPAT → MEPSGSLFPSLVVVGHVVSL AAVWHWRKGHRQAQDEQ in isoform 3. CuratedVSP_005051Add
BLAST
Alternative sequencei1 – 180180MVAGM…PTPAT → DVSNGSSGSPSPGDTLPWNL GKTQRSRRSGGGSVGNGSVL DPAERAVIRIA in isoform 4. CuratedVSP_005052Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X59601 mRNA. Translation: CAA42169.1.
U96274 mRNA. Translation: AAC53209.1.
U96275 mRNA. Translation: AAC53210.1.
U96276 mRNA. Translation: AAC53211.1.
PIRiA39638.
UniGeneiRn.1085.

Genome annotation databases

UCSCiRGD:621649. rat. [P30427-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X59601 mRNA. Translation: CAA42169.1.
U96274 mRNA. Translation: AAC53209.1.
U96275 mRNA. Translation: AAC53210.1.
U96276 mRNA. Translation: AAC53211.1.
PIRiA39638.
UniGeneiRn.1085.

3D structure databases

ProteinModelPortaliP30427.
SMRiP30427. Positions 181-409, 419-636, 2785-3026, 3444-3684, 4024-4263, 4415-4608.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP30427. 2 interactions.
STRINGi10116.ENSRNOP00000040018.

PTM databases

iPTMnetiP30427.
PhosphoSiteiP30427.

Proteomic databases

PaxDbiP30427.
PRIDEiP30427.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

UCSCiRGD:621649. rat. [P30427-1]

Organism-specific databases

RGDi621649. Plec.

Phylogenomic databases

eggNOGiKOG0516. Eukaryota.
COG5069. LUCA.
HOVERGENiHBG053616.
InParanoidiP30427.
PhylomeDBiP30427.

Miscellaneous databases

PROiP30427.

Family and domain databases

Gene3Di1.10.418.10. 2 hits.
3.90.1290.10. 7 hits.
InterProiIPR001589. Actinin_actin-bd_CS.
IPR001715. CH-domain.
IPR030269. Plectin.
IPR001101. Plectin_repeat.
IPR005326. S10_plectin_N.
IPR018159. Spectrin/alpha-actinin.
[Graphical view]
PANTHERiPTHR11915:SF247. PTHR11915:SF247. 4 hits.
PfamiPF00307. CH. 2 hits.
PF00681. Plectin. 18 hits.
PF03501. S10_plectin. 1 hit.
[Graphical view]
SMARTiSM00033. CH. 2 hits.
SM00250. PLEC. 34 hits.
SM00150. SPEC. 6 hits.
[Graphical view]
SUPFAMiSSF47576. SSF47576. 1 hit.
SSF75399. SSF75399. 8 hits.
PROSITEiPS00020. ACTININ_2. 1 hit.
PS50021. CH. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPLEC_RAT
AccessioniPrimary (citable) accession number: P30427
Secondary accession number(s): O08879, O08880, O08881
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: October 1, 1996
Last modified: July 6, 2016
This is version 142 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.