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Protein

NK-tumor recognition protein

Gene

Nktr

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Component of a putative tumor-recognition complex. Involved in the function of NK cells.

Catalytic activityi

Peptidylproline (omega=180) = peptidylproline (omega=0).

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase, Rotamase

Keywords - Ligandi

Cyclosporin

Names & Taxonomyi

Protein namesi
Recommended name:
NK-tumor recognition protein
Short name:
NK-TR protein
Alternative name(s):
Natural-killer cells cyclophilin-related protein
Including the following 1 domains:
Putative peptidyl-prolyl cis-trans isomerase (EC:5.2.1.8)
Short name:
PPIase
Alternative name(s):
Rotamase
Gene namesi
Name:Nktr
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:97346. Nktr.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 14531453NK-tumor recognition proteinPRO_0000064218Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki323 – 323Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei379 – 3791PhosphoserineBy similarity
Modified residuei401 – 4011PhosphoserineBy similarity
Modified residuei416 – 4161PhosphoserineBy similarity
Cross-linki579 – 579Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei611 – 6111PhosphoserineCombined sources
Modified residuei646 – 6461PhosphoserineBy similarity
Cross-linki664 – 664Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei880 – 8801PhosphoserineBy similarity
Modified residuei882 – 8821PhosphoserineBy similarity
Modified residuei884 – 8841PhosphoserineBy similarity
Modified residuei900 – 9001PhosphoserineCombined sources
Modified residuei1139 – 11391PhosphoserineBy similarity
Modified residuei1148 – 11481PhosphoserineCombined sources
Modified residuei1195 – 11951PhosphoserineBy similarity
Cross-linki1249 – 1249Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity
Cross-linki1249 – 1249Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate1 Publication

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP30415.
MaxQBiP30415.
PaxDbiP30415.
PeptideAtlasiP30415.
PRIDEiP30415.

PTM databases

iPTMnetiP30415.
PhosphoSiteiP30415.

Expressioni

Gene expression databases

BgeeiENSMUSG00000032525.
CleanExiMM_NKTR.
ExpressionAtlasiP30415. baseline and differential.
GenevisibleiP30415. MM.

Interactioni

Protein-protein interaction databases

BioGridi201775. 1 interaction.
DIPiDIP-59972N.
IntActiP30415. 2 interactions.
MINTiMINT-4103852.
STRINGi10090.ENSMUSP00000035112.

Structurei

3D structure databases

ProteinModelPortaliP30415.
SMRiP30415. Positions 7-177.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini10 – 175166PPIase cyclophilin-typePROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1303 – 1453151Arg/Ser tandem repeat-richAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi198 – 27376Arg/Ser-richAdd
BLAST
Compositional biasi222 – 24120Arg/Lys-rich (basic)Add
BLAST
Compositional biasi422 – 45938Arg/Lys-rich (basic)Add
BLAST
Compositional biasi468 – 56598Arg/Ser-richAdd
BLAST
Compositional biasi658 – 812155Arg/Ser-richAdd
BLAST
Compositional biasi964 – 100340Arg/Lys-rich (basic)Add
BLAST

Sequence similaritiesi

Contains 1 PPIase cyclophilin-type domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0546. Eukaryota.
COG0652. LUCA.
GeneTreeiENSGT00550000074595.
HOGENOMiHOG000113792.
HOVERGENiHBG052631.
InParanoidiP30415.
KOiK12740.
OMAiDRSAYSK.
OrthoDBiEOG091G0BGL.
TreeFamiTF318563.

Family and domain databases

Gene3Di2.40.100.10. 1 hit.
InterProiIPR029000. Cyclophilin-like_dom.
IPR024936. Cyclophilin-type_PPIase.
IPR020892. Cyclophilin-type_PPIase_CS.
IPR002130. Cyclophilin-type_PPIase_dom.
[Graphical view]
PANTHERiPTHR11071. PTHR11071. 2 hits.
PfamiPF00160. Pro_isomerase. 1 hit.
[Graphical view]
PRINTSiPR00153. CSAPPISMRASE.
SUPFAMiSSF50891. SSF50891. 1 hit.
PROSITEiPS00170. CSA_PPIASE_1. 1 hit.
PS50072. CSA_PPIASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P30415-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGAQDRPQCH FDIEINREPV GRIMFQLFSD ICPKTCKNFL CLCSGEKGLG
60 70 80 90 100
KTTGKKLCYK GSTFHRVVKN FMIQGGDFSE GNGKGGESIY GGYFKDENFI
110 120 130 140 150
LKHDRAFLLS MANRGKHTNG SQFFITTKPA PHLDGVHVVF GLVISGFEVI
160 170 180 190 200
EQIENLKTDA ASRPYADVRV IDCGVLATKL TKDVFEKKRK KPTCSEGSDS
210 220 230 240 250
SSRSSSSSES SSESEVERET IRRRRHKRRP KVRHAKKRRK EMSSSEEPRR
260 270 280 290 300
KRTVSPEGYS ERSDVNEKRS VDSNTKREKP VVRPEEIPPV PENRFLLRRD
310 320 330 340 350
MPAITVEPEQ NIPDVAPVVS DQKPSVSKSG RKIKGRGTIR YHTPPRSRSH
360 370 380 390 400
SESKDDDSSE TPPHWKEEMQ RLRAYRPPSG EKWSKGDKLS DPCSSRWDER
410 420 430 440 450
SLSQRSRSWS YNGYYSDLST ARHSDGHHKK HRKEKKFKHK KKAKKQKHCR
460 470 480 490 500
RHRQTKKRRI VMPDLEPSRS PTHRMKSSCV RERRSRASSS SSHHSSKRDW
510 520 530 540 550
SKSDQDDGSA STHSSRDSYR SKSHSRSDSR GSSRSRAVSK SSSRSLNRSK
560 570 580 590 600
SRSSSRSGPR RTSISPKKPA QLSENKPVKT EPLRPSVPQN GNVLVQPVAA
610 620 630 640 650
ENIPVIPLSD SPPPSRWKPG QKPWKPSYER IQEMKAKTTH LLPVQSTYSL
660 670 680 690 700
TNIKATVSSS SYHKREKPSE SDGSAYSKYS DRSSGSSGRS GSKSSRSRSS
710 720 730 740 750
SRSYTRSRSR SLPTSRSLSR SPSSRSHSPN KYSDGSQHSR SSSYTSVSSD
760 770 780 790 800
DGRRAMFRSN RKKSVTSHKR HRSNSEKTLH SKYVRGREKS SRHRKYSESR
810 820 830 840 850
SSLDYSSDSD QSHVQVYSAP EKEKQGKVEA LNDKQGKGRE EGKPKPEWEC
860 870 880 890 900
PRSKKRTPKD HSRDDSVSKG KNCAGSKWDS ESNSEQDVTK SRKSDPRRGS
910 920 930 940 950
EKEEGEASSD SESEVGQSHI KAKPPAKPPT STFLPGSDGA WKSRRPQSSA
960 970 980 990 1000
SESESSCSNL GNIRGEPQKQ KHSKDDLKGD HTKRAREKSK AKKDKKHKAP
1010 1020 1030 1040 1050
KRKQAFHWQP PLEFGDDEEE EMNGKQVTQD PKEKRHVSEK CEAVKDGIPN
1060 1070 1080 1090 1100
VEKTCDEGSS PSKPKKGTLE QDPLAEGGHD PSSCPAPLKV EDNTASSPPS
1110 1120 1130 1140 1150
AQHLEEHGPG GGEDVLQTDD NMEICTPDRT SPAKGEVVSP LANHRLDSPE
1160 1170 1180 1190 1200
VNIIPEQDEC MAHPRAGGEQ ESSMSESKTL GESGVKQDSS TSVTSPVETS
1210 1220 1230 1240 1250
GKKEGAEKSQ MNLTDKWKPL QGVGNLSVST ATTSSALDVK ALSTVPEVKP
1260 1270 1280 1290 1300
QGLRIEIKSK NKVRPGSLFD EVRKTARLNR RPRNQESSSD DQTPSRDGDS
1310 1320 1330 1340 1350
QSRSPHRSRS KSETKSRHRT RSVSYSHSRS RSRSSTSSYR SRSYSRSRSR
1360 1370 1380 1390 1400
DWYSRGRTRS RSSSYGSFHS HRTSSRSRSR SSSYDLHSRS RSYTYDSYYS
1410 1420 1430 1440 1450
RSRSRSRSQR SDSYHRGRSY NRRSRSGRSY GSDSESDRSY SHHRSPSESS

RYS
Length:1,453
Mass (Da):163,449
Last modified:November 28, 2012 - v4
Checksum:iAA536CDA355CF272
GO

Sequence cautioni

The sequence AAA37500 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti112 – 1121A → V in BAE25777 (PubMed:16141072).Curated
Sequence conflicti567 – 5671K → Q in BAE25777 (PubMed:16141072).Curated
Sequence conflicti601 – 6011E → G in BAE25777 (PubMed:16141072).Curated
Sequence conflicti740 – 7401R → K in BAE25777 (PubMed:16141072).Curated
Sequence conflicti806 – 8061S → T in AAA37500 (PubMed:8421688).Curated
Sequence conflicti856 – 8594RTPK → ENSE in AAA37500 (PubMed:8421688).Curated
Sequence conflicti1203 – 12031K → R in BAE25777 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L04289 mRNA. Translation: AAA37500.2. Different initiation.
AK144214 mRNA. Translation: BAE25777.1.
AC159810 Genomic DNA. No translation available.
AC165080 Genomic DNA. No translation available.
CCDSiCCDS23636.1.
RefSeqiNP_035048.3. NM_010918.2.
UniGeneiMm.32842.
Mm.441099.

Genome annotation databases

EnsembliENSMUST00000035112; ENSMUSP00000035112; ENSMUSG00000032525.
GeneIDi18087.
KEGGimmu:18087.
UCSCiuc009sdr.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L04289 mRNA. Translation: AAA37500.2. Different initiation.
AK144214 mRNA. Translation: BAE25777.1.
AC159810 Genomic DNA. No translation available.
AC165080 Genomic DNA. No translation available.
CCDSiCCDS23636.1.
RefSeqiNP_035048.3. NM_010918.2.
UniGeneiMm.32842.
Mm.441099.

3D structure databases

ProteinModelPortaliP30415.
SMRiP30415. Positions 7-177.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi201775. 1 interaction.
DIPiDIP-59972N.
IntActiP30415. 2 interactions.
MINTiMINT-4103852.
STRINGi10090.ENSMUSP00000035112.

PTM databases

iPTMnetiP30415.
PhosphoSiteiP30415.

Proteomic databases

EPDiP30415.
MaxQBiP30415.
PaxDbiP30415.
PeptideAtlasiP30415.
PRIDEiP30415.

Protocols and materials databases

DNASUi18087.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000035112; ENSMUSP00000035112; ENSMUSG00000032525.
GeneIDi18087.
KEGGimmu:18087.
UCSCiuc009sdr.1. mouse.

Organism-specific databases

CTDi4820.
MGIiMGI:97346. Nktr.

Phylogenomic databases

eggNOGiKOG0546. Eukaryota.
COG0652. LUCA.
GeneTreeiENSGT00550000074595.
HOGENOMiHOG000113792.
HOVERGENiHBG052631.
InParanoidiP30415.
KOiK12740.
OMAiDRSAYSK.
OrthoDBiEOG091G0BGL.
TreeFamiTF318563.

Miscellaneous databases

ChiTaRSiNktr. mouse.
PROiP30415.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000032525.
CleanExiMM_NKTR.
ExpressionAtlasiP30415. baseline and differential.
GenevisibleiP30415. MM.

Family and domain databases

Gene3Di2.40.100.10. 1 hit.
InterProiIPR029000. Cyclophilin-like_dom.
IPR024936. Cyclophilin-type_PPIase.
IPR020892. Cyclophilin-type_PPIase_CS.
IPR002130. Cyclophilin-type_PPIase_dom.
[Graphical view]
PANTHERiPTHR11071. PTHR11071. 2 hits.
PfamiPF00160. Pro_isomerase. 1 hit.
[Graphical view]
PRINTSiPR00153. CSAPPISMRASE.
SUPFAMiSSF50891. SSF50891. 1 hit.
PROSITEiPS00170. CSA_PPIASE_1. 1 hit.
PS50072. CSA_PPIASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNKTR_MOUSE
AccessioniPrimary (citable) accession number: P30415
Secondary accession number(s): F8VPR8, Q3UNH0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: November 28, 2012
Last modified: September 7, 2016
This is version 126 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.