NK-tumor recognition protein - Homo sapiens (Human)

Contribute

Send feedback

Read comments (?) or add your own

P30414 (NKTR_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 97. History...

Clusters with 100%, 90%, 50% identity |

Documents (6) |

Third-party data

text xml rdf/xml gff fasta

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
NK-tumor recognition protein
Short name=NK-TR protein

Alternative name(s):
Natural-killer cells cyclophilin-related protein

Including the following 1 domains:

Putative peptidyl-prolyl cis-trans isomerase
Short name=PPIase
EC=5.2.1.8
Alternative name(s):
Rotamase

Gene names

Name:

NKTR

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	1462 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Component of a putative tumor-recognition complex. Involved in the function of NK cells.
Catalytic activity	Peptidylproline (omega=180) = peptidylproline (omega=0).
Subcellular location	Membrane; Peripheral membrane protein. Note: Attached to the membrane via its N-terminus.
Post-translational modification	Phosphorylated upon DNA damage, probably by ATM or ATR. Ref.4 Ref.5 Ref.6
Sequence similarities	Contains 1 PPIase cyclophilin-type domain.

Ontologies

Keywords
Cellular component	Membrane
Coding sequence diversity	Polymorphism
Domain	Repeat
Ligand	Cyclosporin
Molecular function	Isomerase Rotamase
PTM	Isopeptide bond Phosphoprotein Ubl conjugation
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	protein folding Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	cyclosporin A binding Traceable author statement. Source: ProtInc peptidyl-prolyl cis-trans isomerase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 1462

1462

NK-tumor recognition protein

PRO_0000064217

Regions

Domain

10 – 175

166

PPIase cyclophilin-type

Region

1311 – 1348

Arg/Ser tandem repeat-rich

Compositional bias

194 – 244

Arg/Ser-rich

Compositional bias

219 – 240

Arg/Lys-rich (basic)

Compositional bias

421 – 457

Arg/Lys-rich (basic)

Compositional bias

466 – 574

109

Arg/Ser-rich

Compositional bias

664 – 814

151

Arg/Ser-rich

Compositional bias

970 – 1010

Arg/Lys-rich (basic)

Amino acid modifications

Modified residue

343

Phosphothreonine Ref.4

Modified residue

347

Phosphoserine Ref.4

Modified residue

379

Phosphoserine Ref.4

Modified residue

406

Phosphoserine Ref.4

Modified residue

408

Phosphoserine Ref.4

Modified residue

410

Phosphoserine Ref.4

Modified residue

463

Phosphoserine Ref.6

Modified residue

572

Phosphoserine Ref.5

Modified residue

887

Phosphoserine Ref.6

Modified residue

889

Phosphoserine Ref.6

Modified residue

891

Phosphoserine Ref.6

Modified residue

1146

Phosphoserine By similarity

Cross-link

1258

Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) By similarity

Natural variations

Natural variant

271

V → G.
Corresponds to variant rs35726114 [ dbSNP | Ensembl ].

VAR_061765

Natural variant

861

L → V.
Corresponds to variant rs33969824 [ dbSNP | Ensembl ].

VAR_051773

Natural variant

935

S → L.
Corresponds to variant rs35770315 [ dbSNP | Ensembl ].

VAR_051774

Natural variant

1182

M → T.
Corresponds to variant rs34897686 [ dbSNP | Ensembl ].

VAR_061766

Secondary structure

1462

Helix Strand Turn

Details...

Sequences

Sequence

Length

Mass (Da)

Tools

P30414 [UniParc].

Last modified May 30, 2000. Version 2.
Checksum: D98A1147763EF527
Show »

FASTA

1,462

165,677

        10         20         30         40         50         60 
MGAQDRPQCH FDIEINREPV GRIMFQLFSD ICPKTCKNFL CLCSGEKGLG KTTGKKLCYK 

        70         80         90        100        110        120 
GSTFHRVVKN FMIQGGDFSE GNGKGGESIY GGYFKDENFI LKHDRAFLLS MANRGKHTNG 

       130        140        150        160        170        180 
SQFFITTKPA PHLDGVHVVF GLVISGFEVI EQIENLKTDA ASRPYADVRV IDCGVLATKS 

       190        200        210        220        230        240 
IKDVFEKKRK KPTHSEGSDS SSNSSSSSES SSESELEHER SRRRKHKRRP KVKRSKKRRK 

       250        260        270        280        290        300 
EASSSEEPRN KHAMNPKGHS ERSDTNEKRS VDSSAKREKP VVRPEEIPPV PENRFLLRRD 

       310        320        330        340        350        360 
MPVVTAEPEP KIPDVAPIVS DQKPSVSKSG RKIKGRGTIR YHTPPRSRSC SESDDDDSSE 

       370        380        390        400        410        420 
TPPHWKEEMQ RLRAYRPPSG EKWSKGDKLS DPCSSRWDER SLSQRSRSWS YNGYYSDLST 

       430        440        450        460        470        480 
ARHSGHHKKR RKEKKVKHKK KGKKQKHCRR HKQTKKRRIL IPSDIESSKS STRRMKSSCD 

       490        500        510        520        530        540 
RERSSRSSSL SSHHSSKRDW SKSDKDVQSS LTHSSRDSYR SKSHSQSYSR GSSRSRTASK 

       550        560        570        580        590        600 
SSSHSRSRSK SRSSSKSGHR KRASKSPRKT ASQLSENKPV KTEPLRATMA QNENVVVQPV 

       610        620        630        640        650        660 
VAENIPVIPL SDSPPPSRWK PGQKPWKPSY ERIQEMKAKT THLLPIQSTY SLANIKETGS 

       670        680        690        700        710        720 
SSSYHKREKN SESDQSTYSK YSDRSSESSP RSRSRSSRSR SYSRSYTRSR SLASSHSRSR 

       730        740        750        760        770        780 
SPSSRSHSRN KYSDHSQCSR SSSYTSISSD DGRRAKRRLR SSGKKNSVSH KKHSSSSEKT 

       790        800        810        820        830        840 
LHSKYVKGRD RSSCVRKYSE SRSSLDYSSD SEQSSVQATQ SAQEKEKQGQ MERTHNKQEK 

       850        860        870        880        890        900 
NRGEEKSKSE RECPHSKKRT LKENLSDHLR NGSKPKRKNY AGSKWDSESN SERDVTKNSK 

       910        920        930        940        950        960 
NDSHPSSDKE EGEATSDSES EVSEIHIKVK PTTKSSTNTS LPDDNGAWKS SKQRTSTSDS 

       970        980        990       1000       1010       1020 
EGSCSNSENN RGKPQKHKHG SKENLKREHT KKVKEKLKGK KDKKHKAPKR KQAFHWQPPL 

      1030       1040       1050       1060       1070       1080 
EFGEEEEEEI DDKQVTQESK EKKVSENNET IKDNILKTEK SSEEDLSGKH DTVTVSSDLD 

      1090       1100       1110       1120       1130       1140 
QFTKDDSKLS ISPTALNTEE NVACLQNIQH VEESVPNGVE DVLQTDDNME ICTPDRSSPA 

      1150       1160       1170       1180       1190       1200 
KVEETSPLGN ARLDTPDINI VLKQDMATEH PQAEVVKQES SMSESKVLGE VGKQDSSSAS 

      1210       1220       1230       1240       1250       1260 
LASAGESTGK KEVAEKSQIN LIDKKWKPLQ GVGNLAAPNA ATSSAVEVKV LTTVPEMKPQ 

      1270       1280       1290       1300       1310       1320 
GLRIEIKSKN KVRPGSLFDE VRKTARLNRR PRNQESSSDE QTPSRDDDSQ SRSPSRSRSK 

      1330       1340       1350       1360       1370       1380 
SETKSRHRTR SVSYSHSRSR SRSSTSSYRS RSYSRSRSRG WYSRGRTRSR SSSYRSYKSH 

      1390       1400       1410       1420       1430       1440 
RTSSRSRSRS SSYDPHSRSR SYTYDSYYSR SRSRSRSQRS DSYHRGRSYN RRSRSCRSYG 

      1450       1460 
SDSESDRSYS HHRSPSESSR YS

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A cyclophilin-related protein involved in the function of natural killer cells." Anderson S.K., Gallinger S., Roder J., Frey J., Young H.A., Ortaldo J.R. Proc. Natl. Acad. Sci. U.S.A. 90:542-546(1993) [PubMed: 8421688] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Blood.
[2]	Anderson S.K. Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases Cited for: SEQUENCE REVISION.
[3]	"Structure of the human NKTR gene." Anderson S.K. Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]	"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed: 17081983] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-343; SER-347; SER-379; SER-406; SER-408 AND SER-410, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[5]	"ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage." Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III, Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N., Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J. Science 316:1160-1166(2007) [PubMed: 17525332] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-572, MASS SPECTROMETRY. Tissue: Embryonic kidney.
[6]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-463; SER-887; SER-889 AND SER-891, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

L04288 mRNA. Translation: AAA35734.2.
AF184110 Genomic DNA. Translation: AAD56402.1.

IPI

IPI00295022.

PIR

A47328.

RefSeq

NP_005376.2. NM_005385.3.

UniGene

Hs.529509.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2HE9	X-ray	2.00	A/B	7-179	[»]

ProteinModelPortal

P30414.

SMR

P30414. Positions 7-177.

ModBase

Search...

Protein-protein interaction databases

IntAct

P30414. 5 interactions.

STRING

P30414.

PTM databases

PhosphoSite

P30414.

Polymorphism databases

DMDM

8039798.

Proteomic databases

PeptideAtlas

P30414.

PRIDE

P30414.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000232978; ENSP00000232978; ENSG00000114857.

GeneID

4820.

KEGG

hsa:4820.

UCSC

uc003clo.1. human.

Organism-specific databases

CTD

4820.

GeneCards

GC03P042617.

H-InvDB

HIX0003205.

HGNC

HGNC:7833. NKTR.

HPA

HPA022120.

MIM

161565. gene.

neXtProt

NX_P30414.

PharmGKB

PA31641.

GenAtlas

Search...

Phylogenomic databases

eggNOG

prNOG19584.

HOGENOM

HBG279438.

HOVERGEN

HBG052631.

InParanoid

P30414.

OMA

DNMEICT.

OrthoDB

EOG47SSD2.

PhylomeDB

P30414.

Gene expression databases

ArrayExpress

P30414.

Bgee

P30414.

CleanEx

HS_NKTR.

Genevestigator

P30414.

GermOnline

ENSG00000114857. Homo sapiens.

Family and domain databases

InterPro

IPR002130. Cyclophilin-like_PPIase_dom.
IPR020892. Cyclophilin-type_PPIase_CS.
[Graphical view]

Gene3D

G3DSA:2.40.100.10. PPIase_cyclophilin. 1 hit.

K12740.

Pfam

PF00160. Pro_isomerase. 1 hit.
[Graphical view]

PRINTS

PR00153. CSAPPISMRASE.

SUPFAM

SSF50891. CSA_PPIase. 1 hit.

PROSITE

PS00170. CSA_PPIASE_1. 1 hit.
PS50072. CSA_PPIASE_2. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

NextBio

18572.

PMAP-CutDB

P30414.

SOURCE

Search...

Entry information

Entry name

NKTR_HUMAN

Accession

Primary (citable) accession number: P30414

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 1, 1993
Last sequence update:	May 30, 2000
Last modified:	January 25, 2012
This is version 97 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome 3

Human chromosome 3: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Including the following 1 domains:

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Natural variations

Secondary structure

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents