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Protein

NK-tumor recognition protein

Gene

NKTR

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Component of a putative tumor-recognition complex. Involved in the function of NK cells.

Catalytic activityi

Peptidylproline (omega=180) = peptidylproline (omega=0).

GO - Molecular functioni

  • cyclosporin A binding Source: ProtInc
  • peptidyl-prolyl cis-trans isomerase activity Source: GO_Central

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase, Rotamase

Keywords - Ligandi

Cyclosporin

Enzyme and pathway databases

BioCyciZFISH:ENSG00000114857-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
NK-tumor recognition protein
Short name:
NK-TR protein
Alternative name(s):
Natural-killer cells cyclophilin-related protein
Including the following 1 domains:
Putative peptidyl-prolyl cis-trans isomerase (EC:5.2.1.8)
Short name:
PPIase
Alternative name(s):
Rotamase
Gene namesi
Name:NKTR
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:7833. NKTR.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi4820.
OpenTargetsiENSG00000114857.
PharmGKBiPA31641.

Polymorphism and mutation databases

BioMutaiNKTR.
DMDMi8039798.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000642171 – 1462NK-tumor recognition proteinAdd BLAST1462

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki323Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei379PhosphoserineCombined sources1
Modified residuei401PhosphoserineCombined sources1
Modified residuei416PhosphoserineCombined sources1
Modified residuei463PhosphoserineCombined sources1
Modified residuei471PhosphoserineCombined sources1
Cross-linki581Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei613PhosphoserineBy similarity1
Modified residuei648PhosphoserineCombined sources1
Cross-linki666Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei866PhosphoserineCombined sources1
Modified residuei887PhosphoserineCombined sources1
Modified residuei889PhosphoserineCombined sources1
Modified residuei891PhosphoserineCombined sources1
Modified residuei907PhosphoserineBy similarity1
Cross-linki1057Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei1077PhosphoserineCombined sources1
Modified residuei1146PhosphoserineCombined sources1
Modified residuei1155PhosphothreonineCombined sources1
Cross-linki1177Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)Combined sources
Modified residuei1203PhosphoserineCombined sources1
Cross-linki1258Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP30414.
MaxQBiP30414.
PaxDbiP30414.
PeptideAtlasiP30414.
PRIDEiP30414.

PTM databases

iPTMnetiP30414.
PhosphoSitePlusiP30414.

Miscellaneous databases

PMAP-CutDBP30414.

Expressioni

Gene expression databases

BgeeiENSG00000114857.
CleanExiHS_NKTR.
ExpressionAtlasiP30414. baseline and differential.
GenevisibleiP30414. HS.

Organism-specific databases

HPAiHPA022120.
HPA051576.

Interactioni

Protein-protein interaction databases

BioGridi110885. 22 interactors.
IntActiP30414. 7 interactors.
STRINGi9606.ENSP00000232978.

Structurei

Secondary structure

11462
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi8 – 15Combined sources8
Beta strandi18 – 27Combined sources10
Turni29 – 31Combined sources3
Helixi33 – 44Combined sources12
Turni51 – 53Combined sources3
Beta strandi55 – 57Combined sources3
Beta strandi63 – 68Combined sources6
Turni69 – 71Combined sources3
Beta strandi72 – 75Combined sources4
Turni78 – 80Combined sources3
Beta strandi81 – 84Combined sources4
Beta strandi108 – 111Combined sources4
Beta strandi123 – 128Combined sources6
Helixi131 – 133Combined sources3
Turni134 – 136Combined sources3
Beta strandi139 – 145Combined sources7
Helixi147 – 154Combined sources8
Beta strandi164 – 166Combined sources3
Beta strandi168 – 175Combined sources8

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2HE9X-ray2.00A/B7-179[»]
ProteinModelPortaliP30414.
SMRiP30414.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP30414.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini10 – 175PPIase cyclophilin-typePROSITE-ProRule annotationAdd BLAST166

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1311 – 1348Arg/Ser tandem repeat-richAdd BLAST38

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi194 – 244Arg/Ser-richAdd BLAST51
Compositional biasi219 – 240Arg/Lys-rich (basic)Add BLAST22
Compositional biasi421 – 457Arg/Lys-rich (basic)Add BLAST37
Compositional biasi466 – 574Arg/Ser-richAdd BLAST109
Compositional biasi664 – 814Arg/Ser-richAdd BLAST151
Compositional biasi970 – 1010Arg/Lys-rich (basic)Add BLAST41

Sequence similaritiesi

Contains 1 PPIase cyclophilin-type domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0546. Eukaryota.
COG0652. LUCA.
GeneTreeiENSGT00550000074595.
HOGENOMiHOG000113792.
HOVERGENiHBG052631.
InParanoidiP30414.
KOiK12740.
OMAiDRSAYSK.
OrthoDBiEOG091G0BGL.
PhylomeDBiP30414.
TreeFamiTF318563.

Family and domain databases

Gene3Di2.40.100.10. 1 hit.
InterProiIPR029000. Cyclophilin-like_dom.
IPR024936. Cyclophilin-type_PPIase.
IPR020892. Cyclophilin-type_PPIase_CS.
IPR002130. Cyclophilin-type_PPIase_dom.
[Graphical view]
PANTHERiPTHR11071. PTHR11071. 2 hits.
PfamiPF00160. Pro_isomerase. 1 hit.
[Graphical view]
PRINTSiPR00153. CSAPPISMRASE.
SUPFAMiSSF50891. SSF50891. 1 hit.
PROSITEiPS00170. CSA_PPIASE_1. 1 hit.
PS50072. CSA_PPIASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P30414-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGAQDRPQCH FDIEINREPV GRIMFQLFSD ICPKTCKNFL CLCSGEKGLG
60 70 80 90 100
KTTGKKLCYK GSTFHRVVKN FMIQGGDFSE GNGKGGESIY GGYFKDENFI
110 120 130 140 150
LKHDRAFLLS MANRGKHTNG SQFFITTKPA PHLDGVHVVF GLVISGFEVI
160 170 180 190 200
EQIENLKTDA ASRPYADVRV IDCGVLATKS IKDVFEKKRK KPTHSEGSDS
210 220 230 240 250
SSNSSSSSES SSESELEHER SRRRKHKRRP KVKRSKKRRK EASSSEEPRN
260 270 280 290 300
KHAMNPKGHS ERSDTNEKRS VDSSAKREKP VVRPEEIPPV PENRFLLRRD
310 320 330 340 350
MPVVTAEPEP KIPDVAPIVS DQKPSVSKSG RKIKGRGTIR YHTPPRSRSC
360 370 380 390 400
SESDDDDSSE TPPHWKEEMQ RLRAYRPPSG EKWSKGDKLS DPCSSRWDER
410 420 430 440 450
SLSQRSRSWS YNGYYSDLST ARHSGHHKKR RKEKKVKHKK KGKKQKHCRR
460 470 480 490 500
HKQTKKRRIL IPSDIESSKS STRRMKSSCD RERSSRSSSL SSHHSSKRDW
510 520 530 540 550
SKSDKDVQSS LTHSSRDSYR SKSHSQSYSR GSSRSRTASK SSSHSRSRSK
560 570 580 590 600
SRSSSKSGHR KRASKSPRKT ASQLSENKPV KTEPLRATMA QNENVVVQPV
610 620 630 640 650
VAENIPVIPL SDSPPPSRWK PGQKPWKPSY ERIQEMKAKT THLLPIQSTY
660 670 680 690 700
SLANIKETGS SSSYHKREKN SESDQSTYSK YSDRSSESSP RSRSRSSRSR
710 720 730 740 750
SYSRSYTRSR SLASSHSRSR SPSSRSHSRN KYSDHSQCSR SSSYTSISSD
760 770 780 790 800
DGRRAKRRLR SSGKKNSVSH KKHSSSSEKT LHSKYVKGRD RSSCVRKYSE
810 820 830 840 850
SRSSLDYSSD SEQSSVQATQ SAQEKEKQGQ MERTHNKQEK NRGEEKSKSE
860 870 880 890 900
RECPHSKKRT LKENLSDHLR NGSKPKRKNY AGSKWDSESN SERDVTKNSK
910 920 930 940 950
NDSHPSSDKE EGEATSDSES EVSEIHIKVK PTTKSSTNTS LPDDNGAWKS
960 970 980 990 1000
SKQRTSTSDS EGSCSNSENN RGKPQKHKHG SKENLKREHT KKVKEKLKGK
1010 1020 1030 1040 1050
KDKKHKAPKR KQAFHWQPPL EFGEEEEEEI DDKQVTQESK EKKVSENNET
1060 1070 1080 1090 1100
IKDNILKTEK SSEEDLSGKH DTVTVSSDLD QFTKDDSKLS ISPTALNTEE
1110 1120 1130 1140 1150
NVACLQNIQH VEESVPNGVE DVLQTDDNME ICTPDRSSPA KVEETSPLGN
1160 1170 1180 1190 1200
ARLDTPDINI VLKQDMATEH PQAEVVKQES SMSESKVLGE VGKQDSSSAS
1210 1220 1230 1240 1250
LASAGESTGK KEVAEKSQIN LIDKKWKPLQ GVGNLAAPNA ATSSAVEVKV
1260 1270 1280 1290 1300
LTTVPEMKPQ GLRIEIKSKN KVRPGSLFDE VRKTARLNRR PRNQESSSDE
1310 1320 1330 1340 1350
QTPSRDDDSQ SRSPSRSRSK SETKSRHRTR SVSYSHSRSR SRSSTSSYRS
1360 1370 1380 1390 1400
RSYSRSRSRG WYSRGRTRSR SSSYRSYKSH RTSSRSRSRS SSYDPHSRSR
1410 1420 1430 1440 1450
SYTYDSYYSR SRSRSRSQRS DSYHRGRSYN RRSRSCRSYG SDSESDRSYS
1460
HHRSPSESSR YS
Length:1,462
Mass (Da):165,677
Last modified:May 30, 2000 - v2
Checksum:iD98A1147763EF527
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_061765271V → G.Corresponds to variant rs35726114dbSNPEnsembl.1
Natural variantiVAR_051773861L → V.Corresponds to variant rs33969824dbSNPEnsembl.1
Natural variantiVAR_051774935S → L.Corresponds to variant rs35770315dbSNPEnsembl.1
Natural variantiVAR_0617661182M → T.Corresponds to variant rs34897686dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L04288 mRNA. Translation: AAA35734.2.
AF184110 Genomic DNA. Translation: AAD56402.1.
CCDSiCCDS2702.1.
PIRiA47328.
RefSeqiNP_005376.2. NM_005385.3.
UniGeneiHs.529509.

Genome annotation databases

EnsembliENST00000232978; ENSP00000232978; ENSG00000114857.
GeneIDi4820.
KEGGihsa:4820.
UCSCiuc003clo.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L04288 mRNA. Translation: AAA35734.2.
AF184110 Genomic DNA. Translation: AAD56402.1.
CCDSiCCDS2702.1.
PIRiA47328.
RefSeqiNP_005376.2. NM_005385.3.
UniGeneiHs.529509.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2HE9X-ray2.00A/B7-179[»]
ProteinModelPortaliP30414.
SMRiP30414.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110885. 22 interactors.
IntActiP30414. 7 interactors.
STRINGi9606.ENSP00000232978.

PTM databases

iPTMnetiP30414.
PhosphoSitePlusiP30414.

Polymorphism and mutation databases

BioMutaiNKTR.
DMDMi8039798.

Proteomic databases

EPDiP30414.
MaxQBiP30414.
PaxDbiP30414.
PeptideAtlasiP30414.
PRIDEiP30414.

Protocols and materials databases

DNASUi4820.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000232978; ENSP00000232978; ENSG00000114857.
GeneIDi4820.
KEGGihsa:4820.
UCSCiuc003clo.4. human.

Organism-specific databases

CTDi4820.
DisGeNETi4820.
GeneCardsiNKTR.
HGNCiHGNC:7833. NKTR.
HPAiHPA022120.
HPA051576.
MIMi161565. gene.
neXtProtiNX_P30414.
OpenTargetsiENSG00000114857.
PharmGKBiPA31641.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0546. Eukaryota.
COG0652. LUCA.
GeneTreeiENSGT00550000074595.
HOGENOMiHOG000113792.
HOVERGENiHBG052631.
InParanoidiP30414.
KOiK12740.
OMAiDRSAYSK.
OrthoDBiEOG091G0BGL.
PhylomeDBiP30414.
TreeFamiTF318563.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000114857-MONOMER.

Miscellaneous databases

ChiTaRSiNKTR. human.
EvolutionaryTraceiP30414.
GeneWikiiNKTR.
GenomeRNAii4820.
PMAP-CutDBP30414.
PROiP30414.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000114857.
CleanExiHS_NKTR.
ExpressionAtlasiP30414. baseline and differential.
GenevisibleiP30414. HS.

Family and domain databases

Gene3Di2.40.100.10. 1 hit.
InterProiIPR029000. Cyclophilin-like_dom.
IPR024936. Cyclophilin-type_PPIase.
IPR020892. Cyclophilin-type_PPIase_CS.
IPR002130. Cyclophilin-type_PPIase_dom.
[Graphical view]
PANTHERiPTHR11071. PTHR11071. 2 hits.
PfamiPF00160. Pro_isomerase. 1 hit.
[Graphical view]
PRINTSiPR00153. CSAPPISMRASE.
SUPFAMiSSF50891. SSF50891. 1 hit.
PROSITEiPS00170. CSA_PPIASE_1. 1 hit.
PS50072. CSA_PPIASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNKTR_HUMAN
AccessioniPrimary (citable) accession number: P30414
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: May 30, 2000
Last modified: November 2, 2016
This is version 143 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.