Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Peptidyl-prolyl cis-trans isomerase C

Gene

Ppic

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

Catalytic activityi

Peptidylproline (omega=180) = peptidylproline (omega=0).

Enzyme regulationi

Cyclosporin A (CsA) inhibits CYPC.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase, Rotamase

Keywords - Ligandi

Cyclosporin

Names & Taxonomyi

Protein namesi
Recommended name:
Peptidyl-prolyl cis-trans isomerase C (EC:5.2.1.8)
Short name:
PPIase C
Alternative name(s):
Cyclophilin C
Rotamase C
Gene namesi
Name:Ppic
Synonyms:Cypc
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 18

Organism-specific databases

MGIiMGI:97751. Ppic.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000641481 – 212Peptidyl-prolyl cis-trans isomerase CAdd BLAST212

Proteomic databases

EPDiP30412.
PaxDbiP30412.
PeptideAtlasiP30412.
PRIDEiP30412.

2D gel databases

REPRODUCTION-2DPAGEIPI00130240.

PTM databases

PhosphoSitePlusiP30412.

Expressioni

Gene expression databases

BgeeiENSMUSG00000024538.
CleanExiMM_PPIC.
ExpressionAtlasiP30412. baseline and differential.
GenevisibleiP30412. MM.

Interactioni

Protein-protein interaction databases

IntActiP30412. 3 interactors.
MINTiMINT-4108440.
STRINGi10090.ENSMUSP00000025419.

Structurei

Secondary structure

1212
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi35 – 46Combined sources12
Beta strandi49 – 58Combined sources10
Turni60 – 62Combined sources3
Helixi64 – 75Combined sources12
Turni76 – 78Combined sources3
Beta strandi86 – 91Combined sources6
Turni92 – 94Combined sources3
Beta strandi95 – 98Combined sources4
Beta strandi102 – 107Combined sources6
Beta strandi131 – 134Combined sources4
Beta strandi136 – 138Combined sources3
Beta strandi146 – 151Combined sources6
Helixi154 – 156Combined sources3
Turni157 – 159Combined sources3
Beta strandi162 – 168Combined sources7
Helixi170 – 177Combined sources8
Beta strandi187 – 189Combined sources3
Beta strandi191 – 206Combined sources16

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2RMCX-ray1.64A/C/E/G31-212[»]
ProteinModelPortaliP30412.
SMRiP30412.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP30412.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini41 – 198PPIase cyclophilin-typePROSITE-ProRule annotationAdd BLAST158

Sequence similaritiesi

Belongs to the cyclophilin-type PPIase family.Curated
Contains 1 PPIase cyclophilin-type domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0880. Eukaryota.
ENOG410Z0G4. LUCA.
GeneTreeiENSGT00760000119072.
HOGENOMiHOG000065981.
HOVERGENiHBG001065.
InParanoidiP30412.
KOiK09563.
OMAiDRPLTNC.
OrthoDBiEOG091G0BGL.
PhylomeDBiP30412.
TreeFamiTF354259.

Family and domain databases

Gene3Di2.40.100.10. 1 hit.
InterProiIPR029000. Cyclophilin-like_dom.
IPR024936. Cyclophilin-type_PPIase.
IPR020892. Cyclophilin-type_PPIase_CS.
IPR002130. Cyclophilin-type_PPIase_dom.
[Graphical view]
PANTHERiPTHR11071. PTHR11071. 1 hit.
PfamiPF00160. Pro_isomerase. 1 hit.
[Graphical view]
PRINTSiPR00153. CSAPPISMRASE.
SUPFAMiSSF50891. SSF50891. 1 hit.
PROSITEiPS00170. CSA_PPIASE_1. 1 hit.
PS50072. CSA_PPIASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P30412-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSPGPRLLLP AVLCLGLGAL VSSSGSSGVR KRGPSVTDKV FFDVRIGDKD
60 70 80 90 100
VGRIVIGLFG NVVPKTVENF VALATGEKGY GYKGSIFHRV IKDFMIQGGD
110 120 130 140 150
FTARDGTGGM SIYGETFPDE NFKLKHYGIG WVSMANAGPD TNGSQFFITL
160 170 180 190 200
TKPTWLDGKH VVFGKVLDGM TVVHSIELQA TDGHDRPLTD CTIVNSGKID
210
VKTPFVVEVP DW
Length:212
Mass (Da):22,794
Last modified:April 1, 1993 - v1
Checksum:iC99E7AA5D0FA04B6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M74227 mRNA. Translation: AAA37511.1.
BC025861 mRNA. Translation: AAH25861.1.
CCDSiCCDS29252.1.
PIRiA40047.
RefSeqiNP_032934.1. NM_008908.4.
UniGeneiMm.4587.

Genome annotation databases

EnsembliENSMUST00000025419; ENSMUSP00000025419; ENSMUSG00000024538.
GeneIDi19038.
KEGGimmu:19038.
UCSCiuc008exu.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M74227 mRNA. Translation: AAA37511.1.
BC025861 mRNA. Translation: AAH25861.1.
CCDSiCCDS29252.1.
PIRiA40047.
RefSeqiNP_032934.1. NM_008908.4.
UniGeneiMm.4587.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2RMCX-ray1.64A/C/E/G31-212[»]
ProteinModelPortaliP30412.
SMRiP30412.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP30412. 3 interactors.
MINTiMINT-4108440.
STRINGi10090.ENSMUSP00000025419.

PTM databases

PhosphoSitePlusiP30412.

2D gel databases

REPRODUCTION-2DPAGEIPI00130240.

Proteomic databases

EPDiP30412.
PaxDbiP30412.
PeptideAtlasiP30412.
PRIDEiP30412.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000025419; ENSMUSP00000025419; ENSMUSG00000024538.
GeneIDi19038.
KEGGimmu:19038.
UCSCiuc008exu.1. mouse.

Organism-specific databases

CTDi5480.
MGIiMGI:97751. Ppic.

Phylogenomic databases

eggNOGiKOG0880. Eukaryota.
ENOG410Z0G4. LUCA.
GeneTreeiENSGT00760000119072.
HOGENOMiHOG000065981.
HOVERGENiHBG001065.
InParanoidiP30412.
KOiK09563.
OMAiDRPLTNC.
OrthoDBiEOG091G0BGL.
PhylomeDBiP30412.
TreeFamiTF354259.

Miscellaneous databases

ChiTaRSiPpic. mouse.
EvolutionaryTraceiP30412.
PROiP30412.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000024538.
CleanExiMM_PPIC.
ExpressionAtlasiP30412. baseline and differential.
GenevisibleiP30412. MM.

Family and domain databases

Gene3Di2.40.100.10. 1 hit.
InterProiIPR029000. Cyclophilin-like_dom.
IPR024936. Cyclophilin-type_PPIase.
IPR020892. Cyclophilin-type_PPIase_CS.
IPR002130. Cyclophilin-type_PPIase_dom.
[Graphical view]
PANTHERiPTHR11071. PTHR11071. 1 hit.
PfamiPF00160. Pro_isomerase. 1 hit.
[Graphical view]
PRINTSiPR00153. CSAPPISMRASE.
SUPFAMiSSF50891. SSF50891. 1 hit.
PROSITEiPS00170. CSA_PPIASE_1. 1 hit.
PS50072. CSA_PPIASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPPIC_MOUSE
AccessioniPrimary (citable) accession number: P30412
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: November 2, 2016
This is version 139 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.