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P30412

- PPIC_MOUSE

UniProt

P30412 - PPIC_MOUSE

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Protein

Peptidyl-prolyl cis-trans isomerase C

Gene

Ppic

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

Catalytic activityi

Peptidylproline (omega=180) = peptidylproline (omega=0).

Enzyme regulationi

Cyclosporin A (CsA) inhibits CYPC.

GO - Molecular functioni

  1. peptide binding Source: UniProtKB-KW
  2. peptidyl-prolyl cis-trans isomerase activity Source: UniProtKB-KW

GO - Biological processi

  1. protein folding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Isomerase, Rotamase

Keywords - Ligandi

Cyclosporin

Names & Taxonomyi

Protein namesi
Recommended name:
Peptidyl-prolyl cis-trans isomerase C (EC:5.2.1.8)
Short name:
PPIase C
Alternative name(s):
Cyclophilin C
Rotamase C
Gene namesi
Name:Ppic
Synonyms:Cypc
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 18

Organism-specific databases

MGIiMGI:97751. Ppic.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. extracellular vesicular exosome Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 212212Peptidyl-prolyl cis-trans isomerase CPRO_0000064148Add
BLAST

Proteomic databases

MaxQBiP30412.
PaxDbiP30412.
PRIDEiP30412.

2D gel databases

REPRODUCTION-2DPAGEIPI00130240.

PTM databases

PhosphoSiteiP30412.

Expressioni

Gene expression databases

BgeeiP30412.
CleanExiMM_PPIC.
ExpressionAtlasiP30412. baseline and differential.
GenevestigatoriP30412.

Interactioni

Protein-protein interaction databases

IntActiP30412. 3 interactions.
MINTiMINT-4108440.
STRINGi10090.ENSMUSP00000025419.

Structurei

Secondary structure

1
212
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi35 – 4612
Beta strandi49 – 5810
Turni60 – 623
Helixi64 – 7512
Turni76 – 783
Beta strandi86 – 916
Turni92 – 943
Beta strandi95 – 984
Beta strandi102 – 1076
Beta strandi131 – 1344
Beta strandi136 – 1383
Beta strandi146 – 1516
Helixi154 – 1563
Turni157 – 1593
Beta strandi162 – 1687
Helixi170 – 1778
Beta strandi187 – 1893
Beta strandi191 – 20616

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2RMCX-ray1.64A/C/E/G31-212[»]
ProteinModelPortaliP30412.
SMRiP30412. Positions 31-212.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP30412.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini41 – 198158PPIase cyclophilin-typePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the cyclophilin-type PPIase family.Curated
Contains 1 PPIase cyclophilin-type domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0652.
HOGENOMiHOG000065981.
HOVERGENiHBG001065.
InParanoidiP30412.
KOiK09563.
OMAiKIGDKDI.
OrthoDBiEOG7RFTK4.
PhylomeDBiP30412.
TreeFamiTF354259.

Family and domain databases

Gene3Di2.40.100.10. 1 hit.
InterProiIPR029000. Cyclophilin-like_dom.
IPR024936. Cyclophilin-type_PPIase.
IPR020892. Cyclophilin-type_PPIase_CS.
IPR002130. Cyclophilin-type_PPIase_dom.
[Graphical view]
PfamiPF00160. Pro_isomerase. 1 hit.
[Graphical view]
PIRSFiPIRSF001467. Peptidylpro_ismrse. 1 hit.
PRINTSiPR00153. CSAPPISMRASE.
SUPFAMiSSF50891. SSF50891. 1 hit.
PROSITEiPS00170. CSA_PPIASE_1. 1 hit.
PS50072. CSA_PPIASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P30412-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSPGPRLLLP AVLCLGLGAL VSSSGSSGVR KRGPSVTDKV FFDVRIGDKD
60 70 80 90 100
VGRIVIGLFG NVVPKTVENF VALATGEKGY GYKGSIFHRV IKDFMIQGGD
110 120 130 140 150
FTARDGTGGM SIYGETFPDE NFKLKHYGIG WVSMANAGPD TNGSQFFITL
160 170 180 190 200
TKPTWLDGKH VVFGKVLDGM TVVHSIELQA TDGHDRPLTD CTIVNSGKID
210
VKTPFVVEVP DW
Length:212
Mass (Da):22,794
Last modified:April 1, 1993 - v1
Checksum:iC99E7AA5D0FA04B6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M74227 mRNA. Translation: AAA37511.1.
BC025861 mRNA. Translation: AAH25861.1.
CCDSiCCDS29252.1.
PIRiA40047.
RefSeqiNP_032934.1. NM_008908.4.
UniGeneiMm.4587.

Genome annotation databases

EnsembliENSMUST00000025419; ENSMUSP00000025419; ENSMUSG00000024538.
GeneIDi19038.
KEGGimmu:19038.
UCSCiuc008exu.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M74227 mRNA. Translation: AAA37511.1 .
BC025861 mRNA. Translation: AAH25861.1 .
CCDSi CCDS29252.1.
PIRi A40047.
RefSeqi NP_032934.1. NM_008908.4.
UniGenei Mm.4587.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2RMC X-ray 1.64 A/C/E/G 31-212 [» ]
ProteinModelPortali P30412.
SMRi P30412. Positions 31-212.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P30412. 3 interactions.
MINTi MINT-4108440.
STRINGi 10090.ENSMUSP00000025419.

PTM databases

PhosphoSitei P30412.

2D gel databases

REPRODUCTION-2DPAGE IPI00130240.

Proteomic databases

MaxQBi P30412.
PaxDbi P30412.
PRIDEi P30412.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000025419 ; ENSMUSP00000025419 ; ENSMUSG00000024538 .
GeneIDi 19038.
KEGGi mmu:19038.
UCSCi uc008exu.1. mouse.

Organism-specific databases

CTDi 5480.
MGIi MGI:97751. Ppic.

Phylogenomic databases

eggNOGi COG0652.
HOGENOMi HOG000065981.
HOVERGENi HBG001065.
InParanoidi P30412.
KOi K09563.
OMAi KIGDKDI.
OrthoDBi EOG7RFTK4.
PhylomeDBi P30412.
TreeFami TF354259.

Miscellaneous databases

ChiTaRSi PPIC. mouse.
EvolutionaryTracei P30412.
NextBioi 295481.
PROi P30412.
SOURCEi Search...

Gene expression databases

Bgeei P30412.
CleanExi MM_PPIC.
ExpressionAtlasi P30412. baseline and differential.
Genevestigatori P30412.

Family and domain databases

Gene3Di 2.40.100.10. 1 hit.
InterProi IPR029000. Cyclophilin-like_dom.
IPR024936. Cyclophilin-type_PPIase.
IPR020892. Cyclophilin-type_PPIase_CS.
IPR002130. Cyclophilin-type_PPIase_dom.
[Graphical view ]
Pfami PF00160. Pro_isomerase. 1 hit.
[Graphical view ]
PIRSFi PIRSF001467. Peptidylpro_ismrse. 1 hit.
PRINTSi PR00153. CSAPPISMRASE.
SUPFAMi SSF50891. SSF50891. 1 hit.
PROSITEi PS00170. CSA_PPIASE_1. 1 hit.
PS50072. CSA_PPIASE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Two cytoplasmic candidates for immunophilin action are revealed by affinity for a new cyclophilin: one in the presence and one in the absence of CsA."
    Friedman J., Weissman I.L.
    Cell 66:799-806(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Mammary gland.
  3. "Crystal structure of murine cyclophilin C complexed with immunosuppressive drug cyclosporin A."
    Ke H., Zhao Y., Luo F., Weissman I.L., Friedman J.
    Proc. Natl. Acad. Sci. U.S.A. 90:11850-11854(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.64 ANGSTROMS) IN COMPLEX WITH CSA.

Entry informationi

Entry nameiPPIC_MOUSE
AccessioniPrimary (citable) accession number: P30412
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: October 29, 2014
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3