UniProtKB - P30412 (PPIC_MOUSE)
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Protein
Peptidyl-prolyl cis-trans isomerase C
Gene
Ppic
Organism
Mus musculus (Mouse)
Status
Functioni
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
Catalytic activityi
Peptidylproline (omega=180) = peptidylproline (omega=0).
Enzyme regulationi
Cyclosporin A (CsA) inhibits CYPC.
GO - Molecular functioni
- cyclosporin A binding Source: MGI
- peptidyl-prolyl cis-trans isomerase activity Source: GO_Central
GO - Biological processi
- protein folding Source: InterPro
Keywordsi
Molecular function | Isomerase, Rotamase |
Names & Taxonomyi
Protein namesi | Recommended name: Peptidyl-prolyl cis-trans isomerase C (EC:5.2.1.8)Short name: PPIase C Alternative name(s): Cyclophilin C Rotamase C |
Gene namesi | Name:Ppic Synonyms:Cypc |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:97751. Ppic. |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000064148 | 1 – 212 | Peptidyl-prolyl cis-trans isomerase CAdd BLAST | 212 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 78 | N6-succinyllysineBy similarity | 1 | |
Modified residuei | 159 | N6-acetyllysineBy similarity | 1 |
Keywords - PTMi
AcetylationProteomic databases
EPDi | P30412. |
PaxDbi | P30412. |
PeptideAtlasi | P30412. |
PRIDEi | P30412. |
2D gel databases
REPRODUCTION-2DPAGEi | IPI00130240. |
PTM databases
PhosphoSitePlusi | P30412. |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000024538. |
CleanExi | MM_PPIC. |
ExpressionAtlasi | P30412. baseline and differential. |
Genevisiblei | P30412. MM. |
Interactioni
Protein-protein interaction databases
IntActi | P30412. 3 interactors. |
MINTi | P30412. |
STRINGi | 10090.ENSMUSP00000025419. |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more detailsFeature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Beta strandi | 35 – 46 | Combined sources | 12 | |
Beta strandi | 49 – 58 | Combined sources | 10 | |
Turni | 60 – 62 | Combined sources | 3 | |
Helixi | 64 – 75 | Combined sources | 12 | |
Turni | 76 – 78 | Combined sources | 3 | |
Beta strandi | 86 – 91 | Combined sources | 6 | |
Turni | 92 – 94 | Combined sources | 3 | |
Beta strandi | 95 – 98 | Combined sources | 4 | |
Beta strandi | 102 – 107 | Combined sources | 6 | |
Beta strandi | 131 – 134 | Combined sources | 4 | |
Beta strandi | 136 – 138 | Combined sources | 3 | |
Beta strandi | 146 – 151 | Combined sources | 6 | |
Helixi | 154 – 156 | Combined sources | 3 | |
Turni | 157 – 159 | Combined sources | 3 | |
Beta strandi | 162 – 168 | Combined sources | 7 | |
Helixi | 170 – 177 | Combined sources | 8 | |
Beta strandi | 187 – 189 | Combined sources | 3 | |
Beta strandi | 191 – 206 | Combined sources | 16 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2RMC | X-ray | 1.64 | A/C/E/G | 31-212 | [»] | |
ProteinModelPortali | P30412. | |||||
SMRi | P30412. | |||||
ModBasei | Search... | |||||
MobiDBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P30412. |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 41 – 198 | PPIase cyclophilin-typePROSITE-ProRule annotationAdd BLAST | 158 |
Sequence similaritiesi
Belongs to the cyclophilin-type PPIase family.Curated
Phylogenomic databases
eggNOGi | KOG0880. Eukaryota. ENOG410Z0G4. LUCA. |
GeneTreei | ENSGT00760000119072. |
HOGENOMi | HOG000065981. |
HOVERGENi | HBG001065. |
InParanoidi | P30412. |
KOi | K09563. |
OMAi | DRPLTNC. |
OrthoDBi | EOG091G0BGL. |
PhylomeDBi | P30412. |
TreeFami | TF354259. |
Family and domain databases
Gene3Di | 2.40.100.10. 1 hit. |
InterProi | View protein in InterPro IPR029000. Cyclophilin-like_dom_sf. IPR024936. Cyclophilin-type_PPIase. IPR020892. Cyclophilin-type_PPIase_CS. IPR002130. Cyclophilin-type_PPIase_dom. |
PANTHERi | PTHR11071. PTHR11071. 1 hit. |
Pfami | View protein in Pfam PF00160. Pro_isomerase. 1 hit. |
PIRSFi | PIRSF001467. Peptidylpro_ismrse. 1 hit. |
PRINTSi | PR00153. CSAPPISMRASE. |
SUPFAMi | SSF50891. SSF50891. 1 hit. |
PROSITEi | View protein in PROSITE PS00170. CSA_PPIASE_1. 1 hit. PS50072. CSA_PPIASE_2. 1 hit. |
i Sequence
Sequence statusi: Complete.
P30412-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSPGPRLLLP AVLCLGLGAL VSSSGSSGVR KRGPSVTDKV FFDVRIGDKD
60 70 80 90 100
VGRIVIGLFG NVVPKTVENF VALATGEKGY GYKGSIFHRV IKDFMIQGGD
110 120 130 140 150
FTARDGTGGM SIYGETFPDE NFKLKHYGIG WVSMANAGPD TNGSQFFITL
160 170 180 190 200
TKPTWLDGKH VVFGKVLDGM TVVHSIELQA TDGHDRPLTD CTIVNSGKID
210
VKTPFVVEVP DW
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M74227 mRNA. Translation: AAA37511.1. BC025861 mRNA. Translation: AAH25861.1. |
CCDSi | CCDS29252.1. |
PIRi | A40047. |
RefSeqi | NP_032934.1. NM_008908.4. |
UniGenei | Mm.4587. |
Genome annotation databases
Ensembli | ENSMUST00000025419; ENSMUSP00000025419; ENSMUSG00000024538. |
GeneIDi | 19038. |
KEGGi | mmu:19038. |
UCSCi | uc008exu.1. mouse. |
Similar proteinsi
Entry informationi
Entry namei | PPIC_MOUSE | |
Accessioni | P30412Primary (citable) accession number: P30412 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 1, 1993 |
Last sequence update: | April 1, 1993 | |
Last modified: | February 28, 2018 | |
This is version 148 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |