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Protein

Peptidyl-prolyl cis-trans isomerase C

Gene

Ppic

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

Catalytic activityi

Peptidylproline (omega=180) = peptidylproline (omega=0).

Enzyme regulationi

Cyclosporin A (CsA) inhibits CYPC.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase, Rotamase

Names & Taxonomyi

Protein namesi
Recommended name:
Peptidyl-prolyl cis-trans isomerase C (EC:5.2.1.8)
Short name:
PPIase C
Alternative name(s):
Cyclophilin C
Rotamase C
Gene namesi
Name:Ppic
Synonyms:Cypc
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 18

Organism-specific databases

MGIiMGI:97751 Ppic

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000641481 – 212Peptidyl-prolyl cis-trans isomerase CAdd BLAST212

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei78N6-succinyllysineBy similarity1
Modified residuei159N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiP30412
PaxDbiP30412
PeptideAtlasiP30412
PRIDEiP30412

2D gel databases

REPRODUCTION-2DPAGEiIPI00130240

PTM databases

PhosphoSitePlusiP30412

Expressioni

Gene expression databases

BgeeiENSMUSG00000024538
CleanExiMM_PPIC
ExpressionAtlasiP30412 baseline and differential
GenevisibleiP30412 MM

Interactioni

Protein-protein interaction databases

IntActiP30412, 3 interactors
MINTiP30412
STRINGi10090.ENSMUSP00000025419

Structurei

Secondary structure

1212
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi35 – 46Combined sources12
Beta strandi49 – 58Combined sources10
Turni60 – 62Combined sources3
Helixi64 – 75Combined sources12
Turni76 – 78Combined sources3
Beta strandi86 – 91Combined sources6
Turni92 – 94Combined sources3
Beta strandi95 – 98Combined sources4
Beta strandi102 – 107Combined sources6
Beta strandi131 – 134Combined sources4
Beta strandi136 – 138Combined sources3
Beta strandi146 – 151Combined sources6
Helixi154 – 156Combined sources3
Turni157 – 159Combined sources3
Beta strandi162 – 168Combined sources7
Helixi170 – 177Combined sources8
Beta strandi187 – 189Combined sources3
Beta strandi191 – 206Combined sources16

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2RMCX-ray1.64A/C/E/G31-212[»]
ProteinModelPortaliP30412
SMRiP30412
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP30412

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini41 – 198PPIase cyclophilin-typePROSITE-ProRule annotationAdd BLAST158

Sequence similaritiesi

Belongs to the cyclophilin-type PPIase family.Curated

Phylogenomic databases

eggNOGiKOG0880 Eukaryota
ENOG410Z0G4 LUCA
GeneTreeiENSGT00760000119072
HOGENOMiHOG000065981
HOVERGENiHBG001065
InParanoidiP30412
KOiK09563
OMAiDRPLTNC
OrthoDBiEOG091G0BGL
PhylomeDBiP30412
TreeFamiTF354259

Family and domain databases

Gene3Di2.40.100.10, 1 hit
InterProiView protein in InterPro
IPR029000 Cyclophilin-like_dom_sf
IPR024936 Cyclophilin-type_PPIase
IPR020892 Cyclophilin-type_PPIase_CS
IPR002130 Cyclophilin-type_PPIase_dom
PANTHERiPTHR11071 PTHR11071, 1 hit
PfamiView protein in Pfam
PF00160 Pro_isomerase, 1 hit
PIRSFiPIRSF001467 Peptidylpro_ismrse, 1 hit
PRINTSiPR00153 CSAPPISMRASE
SUPFAMiSSF50891 SSF50891, 1 hit
PROSITEiView protein in PROSITE
PS00170 CSA_PPIASE_1, 1 hit
PS50072 CSA_PPIASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

P30412-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSPGPRLLLP AVLCLGLGAL VSSSGSSGVR KRGPSVTDKV FFDVRIGDKD
60 70 80 90 100
VGRIVIGLFG NVVPKTVENF VALATGEKGY GYKGSIFHRV IKDFMIQGGD
110 120 130 140 150
FTARDGTGGM SIYGETFPDE NFKLKHYGIG WVSMANAGPD TNGSQFFITL
160 170 180 190 200
TKPTWLDGKH VVFGKVLDGM TVVHSIELQA TDGHDRPLTD CTIVNSGKID
210
VKTPFVVEVP DW
Length:212
Mass (Da):22,794
Last modified:April 1, 1993 - v1
Checksum:iC99E7AA5D0FA04B6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M74227 mRNA Translation: AAA37511.1
BC025861 mRNA Translation: AAH25861.1
CCDSiCCDS29252.1
PIRiA40047
RefSeqiNP_032934.1, NM_008908.4
UniGeneiMm.4587

Genome annotation databases

EnsembliENSMUST00000025419; ENSMUSP00000025419; ENSMUSG00000024538
GeneIDi19038
KEGGimmu:19038
UCSCiuc008exu.1 mouse

Similar proteinsi

Entry informationi

Entry nameiPPIC_MOUSE
AccessioniPrimary (citable) accession number: P30412
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: February 28, 2018
This is version 148 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

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