Ppic

Functionⁱ

PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

Catalytic activityⁱ

Peptidylproline (omega=180) = peptidylproline (omega=0).

Enzyme regulationⁱ

Cyclosporin A (CsA) inhibits CYPC.

GO - Molecular functionⁱ

cyclosporin A binding Source: MGI
peptidyl-prolyl cis-trans isomerase activity Source: GO_Central

Complete GO annotation...

GO - Biological processⁱ

protein folding Source: InterPro

Complete GO annotation...

Keywordsⁱ

Molecular function	Isomerase, Rotamase

Molecular function

Isomerase, Rotamase

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Peptidyl-prolyl cis-trans isomerase C (EC:5.2.1.8) Short name: PPIase C Alternative name(s): Cyclophilin C Rotamase C
Gene namesⁱ	Name:Ppic Synonyms:Cypc
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 18

Organism-specific databases

MGIⁱ	MGI:97751. Ppic.

Subcellular locationⁱ

Cytoplasm

GO - Cellular componentⁱ

cytoplasm Source: UniProtKB-SubCell
extracellular exosome Source: MGI

Complete GO annotation...

Keywords - Cellular componentⁱ

Cytoplasm

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000064148	1 – 212	Peptidyl-prolyl cis-trans isomerase CAdd BLAST		212

Proteomic databases

EPDⁱ	P30412.
PaxDbⁱ	P30412.
PeptideAtlas More...PeptideAtlasⁱ	P30412.
PRIDEⁱ	P30412.

2D gel databases

REPRODUCTION-2DPAGE More...REPRODUCTION-2DPAGEⁱ	IPI00130240.

REPRODUCTION-2DPAGEⁱ

IPI00130240.

PTM databases

PhosphoSitePlusⁱ	P30412.

PhosphoSitePlusⁱ

P30412.

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000024538.
CleanExⁱ	MM_PPIC.
ExpressionAtlasⁱ	P30412. baseline and differential.
Genevisibleⁱ	P30412. MM.

Interactionⁱ

Protein-protein interaction databases

IntActⁱ	P30412. 3 interactors.
Molecular INTeraction database More...MINTⁱ	MINT-4108440.
STRINGⁱ	10090.ENSMUSP00000025419.

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Show more details

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	35 – 46	Combined sources	12
Beta strandⁱ	49 – 58	Combined sources	10
Turnⁱ	60 – 62	Combined sources	3
Helixⁱ	64 – 75	Combined sources	12
Turnⁱ	76 – 78	Combined sources	3
Beta strandⁱ	86 – 91	Combined sources	6
Turnⁱ	92 – 94	Combined sources	3
Beta strandⁱ	95 – 98	Combined sources	4
Beta strandⁱ	102 – 107	Combined sources	6
Beta strandⁱ	131 – 134	Combined sources	4
Beta strandⁱ	136 – 138	Combined sources	3
Beta strandⁱ	146 – 151	Combined sources	6
Helixⁱ	154 – 156	Combined sources	3
Turnⁱ	157 – 159	Combined sources	3
Beta strandⁱ	162 – 168	Combined sources	7
Helixⁱ	170 – 177	Combined sources	8
Beta strandⁱ	187 – 189	Combined sources	3
Beta strandⁱ	191 – 206	Combined sources	16

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2RMC	X-ray	1.64	A/C/E/G	31-212	[»]
ProteinModelPortalⁱ	P30412.
SMRⁱ	P30412.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	P30412.

EvolutionaryTraceⁱ

P30412.

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	41 – 198	PPIase cyclophilin-typePROSITE-ProRule annotationAdd BLAST		158

Sequence similaritiesⁱ

Belongs to the cyclophilin-type PPIase family.Curated

Phylogenomic databases

eggNOGⁱ	KOG0880. Eukaryota. ENOG410Z0G4. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000119072.
HOGENOMⁱ	HOG000065981.
HOVERGENⁱ	HBG001065.
InParanoidⁱ	P30412.
KEGG Orthology (KO) More...KOⁱ	K09563.
OMAⁱ	DRPLTNC.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0BGL.
PhylomeDBⁱ	P30412.
TreeFamⁱ	TF354259.

Family and domain databases

Gene3Dⁱ	2.40.100.10. 1 hit.
InterProⁱ	View protein in InterPro IPR029000. Cyclophilin-like_dom. IPR024936. Cyclophilin-type_PPIase. IPR020892. Cyclophilin-type_PPIase_CS. IPR002130. Cyclophilin-type_PPIase_dom.
PANTHERⁱ	PTHR11071. PTHR11071. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00160. Pro_isomerase. 1 hit.
PIRSFⁱ	PIRSF001467. Peptidylpro_ismrse. 1 hit.
PRINTSⁱ	PR00153. CSAPPISMRASE.
SUPFAMⁱ	SSF50891. SSF50891. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00170. CSA_PPIASE_1. 1 hit. PS50072. CSA_PPIASE_2. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

P30412-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MSPGPRLLLP AVLCLGLGAL VSSSGSSGVR KRGPSVTDKV FFDVRIGDKD 
        60         70         80         90        100
VGRIVIGLFG NVVPKTVENF VALATGEKGY GYKGSIFHRV IKDFMIQGGD 
       110        120        130        140        150
FTARDGTGGM SIYGETFPDE NFKLKHYGIG WVSMANAGPD TNGSQFFITL 
       160        170        180        190        200
TKPTWLDGKH VVFGKVLDGM TVVHSIELQA TDGHDRPLTD CTIVNSGKID 
       210 
VKTPFVVEVP DW

Length:212

Mass (Da):22,794

Last modified:April 1, 1993 - v1

Checksum:ⁱC99E7AA5D0FA04B6

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M74227 mRNA. Translation: AAA37511.1. BC025861 mRNA. Translation: AAH25861.1.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS29252.1.
PIRⁱ	A40047.
NCBI Reference Sequences More...RefSeqⁱ	NP_032934.1. NM_008908.4.
UniGeneⁱ	Mm.4587.

Genome annotation databases

Ensemblⁱ	ENSMUST00000025419; ENSMUSP00000025419; ENSMUSG00000024538.
GeneIDⁱ	19038.
KEGGⁱ	mmu:19038.
UCSC genome browser More...UCSCⁱ	uc008exu.1. mouse.

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M74227 mRNA. Translation: AAA37511.1. BC025861 mRNA. Translation: AAH25861.1.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS29252.1.
PIRⁱ	A40047.
NCBI Reference Sequences More...RefSeqⁱ	NP_032934.1. NM_008908.4.
UniGeneⁱ	Mm.4587.

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2RMC	X-ray	1.64	A/C/E/G	31-212	[»]
ProteinModelPortalⁱ	P30412.
SMRⁱ	P30412.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

IntActⁱ	P30412. 3 interactors.
Molecular INTeraction database More...MINTⁱ	MINT-4108440.
STRINGⁱ	10090.ENSMUSP00000025419.

PTM databases

PhosphoSitePlusⁱ	P30412.

PhosphoSitePlusⁱ

P30412.

2D gel databases

REPRODUCTION-2DPAGE More...REPRODUCTION-2DPAGEⁱ	IPI00130240.

REPRODUCTION-2DPAGEⁱ

IPI00130240.

Proteomic databases

EPDⁱ	P30412.
PaxDbⁱ	P30412.
PeptideAtlas More...PeptideAtlasⁱ	P30412.
PRIDEⁱ	P30412.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000025419; ENSMUSP00000025419; ENSMUSG00000024538.
GeneIDⁱ	19038.
KEGGⁱ	mmu:19038.
UCSC genome browser More...UCSCⁱ	uc008exu.1. mouse.

Organism-specific databases

CTDⁱ	5480.
MGIⁱ	MGI:97751. Ppic.

Phylogenomic databases

eggNOGⁱ	KOG0880. Eukaryota. ENOG410Z0G4. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000119072.
HOGENOMⁱ	HOG000065981.
HOVERGENⁱ	HBG001065.
InParanoidⁱ	P30412.
KEGG Orthology (KO) More...KOⁱ	K09563.
OMAⁱ	DRPLTNC.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0BGL.
PhylomeDBⁱ	P30412.
TreeFamⁱ	TF354259.

Miscellaneous databases

ChiTaRSⁱ	Ppic. mouse.
EvolutionaryTraceⁱ	P30412.
Protein Ontology More...PROⁱ	PR:P30412.
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000024538.
CleanExⁱ	MM_PPIC.
ExpressionAtlasⁱ	P30412. baseline and differential.
Genevisibleⁱ	P30412. MM.

Family and domain databases

Gene3Dⁱ	2.40.100.10. 1 hit.
InterProⁱ	View protein in InterPro IPR029000. Cyclophilin-like_dom. IPR024936. Cyclophilin-type_PPIase. IPR020892. Cyclophilin-type_PPIase_CS. IPR002130. Cyclophilin-type_PPIase_dom.
PANTHERⁱ	PTHR11071. PTHR11071. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00160. Pro_isomerase. 1 hit.
PIRSFⁱ	PIRSF001467. Peptidylpro_ismrse. 1 hit.
PRINTSⁱ	PR00153. CSAPPISMRASE.
SUPFAMⁱ	SSF50891. SSF50891. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00170. CSA_PPIASE_1. 1 hit. PS50072. CSA_PPIASE_2. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	PPIC_MOUSE
Accessionⁱ	P30412Primary (citable) accession number: P30412
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	April 1, 1993
	Last sequence update:	April 1, 1993
	Last modified:	July 5, 2017
	This is version 145 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
SIMILARITY comments
Index of protein domains and families

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P30412 (PPIC_MOUSE)

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Peptidyl-prolyl cis-trans isomerase C

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the ‘Function’ section describes an enzyme regulatory mechanism and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/enzyme_regulation' target='_top'>More...</a></p>Enzyme regulationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

2D gel databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

2D gel databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

Functionⁱ

Enzyme regulationⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ