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UniProtKB - P30412 (PPIC_MOUSE)

UniProt

P30412 - PPIC_MOUSE

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Protein

Peptidyl-prolyl cis-trans isomerase C

Gene

Ppic

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

Catalytic activityi

Peptidylproline (omega=180) = peptidylproline (omega=0).

Enzyme regulationi

Cyclosporin A (CsA) inhibits CYPC.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase, Rotamase

Keywords - Ligandi

Cyclosporin

Names & Taxonomyi

Protein namesi
Recommended name:
Peptidyl-prolyl cis-trans isomerase C (EC:5.2.1.8)
Short name:
PPIase C
Alternative name(s):
Cyclophilin C
Rotamase C
Gene namesi
Name:Ppic
Synonyms:Cypc
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesi
  • UP000000589 Componenti: Chromosome 18

Organism-specific databases

MGIiMGI:97751. Ppic.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 212212Peptidyl-prolyl cis-trans isomerase CPRO_0000064148Add
BLAST

Proteomic databases

EPDiP30412.
PaxDbiP30412.
PeptideAtlasiP30412.
PRIDEiP30412.

2D gel databases

REPRODUCTION-2DPAGEIPI00130240.

PTM databases

PhosphoSiteiP30412.

Expressioni

Gene expression databases

BgeeiENSMUSG00000024538.
CleanExiMM_PPIC.
ExpressionAtlasiP30412. baseline and differential.
GenevisibleiP30412. MM.

Interactioni

Protein-protein interaction databases

IntActiP30412. 3 interactions.
MINTiMINT-4108440.
STRINGi10090.ENSMUSP00000025419.

Structurei

Secondary structure

1
212
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi35 – 4612Combined sources
Beta strandi49 – 5810Combined sources
Turni60 – 623Combined sources
Helixi64 – 7512Combined sources
Turni76 – 783Combined sources
Beta strandi86 – 916Combined sources
Turni92 – 943Combined sources
Beta strandi95 – 984Combined sources
Beta strandi102 – 1076Combined sources
Beta strandi131 – 1344Combined sources
Beta strandi136 – 1383Combined sources
Beta strandi146 – 1516Combined sources
Helixi154 – 1563Combined sources
Turni157 – 1593Combined sources
Beta strandi162 – 1687Combined sources
Helixi170 – 1778Combined sources
Beta strandi187 – 1893Combined sources
Beta strandi191 – 20616Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2RMCX-ray1.64A/C/E/G31-212[»]
ProteinModelPortaliP30412.
SMRiP30412. Positions 31-212.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP30412.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini41 – 198158PPIase cyclophilin-typePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the cyclophilin-type PPIase family.Curated
Contains 1 PPIase cyclophilin-type domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0880. Eukaryota.
ENOG410Z0G4. LUCA.
HOGENOMiHOG000065981.
HOVERGENiHBG001065.
InParanoidiP30412.
KOiK09563.
OMAiDRPLTNC.
OrthoDBiEOG091G0BGL.
PhylomeDBiP30412.
TreeFamiTF354259.

Family and domain databases

Gene3Di2.40.100.10. 1 hit.
InterProiIPR029000. Cyclophilin-like_dom.
IPR024936. Cyclophilin-type_PPIase.
IPR020892. Cyclophilin-type_PPIase_CS.
IPR002130. Cyclophilin-type_PPIase_dom.
[Graphical view]
PANTHERiPTHR11071. PTHR11071. 1 hit.
PfamiPF00160. Pro_isomerase. 1 hit.
[Graphical view]
PRINTSiPR00153. CSAPPISMRASE.
SUPFAMiSSF50891. SSF50891. 1 hit.
PROSITEiPS00170. CSA_PPIASE_1. 1 hit.
PS50072. CSA_PPIASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P30412-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSPGPRLLLP AVLCLGLGAL VSSSGSSGVR KRGPSVTDKV FFDVRIGDKD 
        60         70         80         90        100
VGRIVIGLFG NVVPKTVENF VALATGEKGY GYKGSIFHRV IKDFMIQGGD 
       110        120        130        140        150
FTARDGTGGM SIYGETFPDE NFKLKHYGIG WVSMANAGPD TNGSQFFITL 
       160        170        180        190        200
TKPTWLDGKH VVFGKVLDGM TVVHSIELQA TDGHDRPLTD CTIVNSGKID 
       210 
VKTPFVVEVP DW
Length:212
Mass (Da):22,794
Last modified:April 1, 1993 - v1
Checksum:iC99E7AA5D0FA04B6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M74227 mRNA. Translation: AAA37511.1.
BC025861 mRNA. Translation: AAH25861.1.
CCDSiCCDS29252.1.
PIRiA40047.
RefSeqiNP_032934.1. NM_008908.4.
UniGeneiMm.4587.

Genome annotation databases

EnsembliENSMUST00000025419; ENSMUSP00000025419; ENSMUSG00000024538.
GeneIDi19038.
KEGGimmu:19038.
UCSCiuc008exu.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M74227 mRNA. Translation: AAA37511.1.
BC025861 mRNA. Translation: AAH25861.1.
CCDSiCCDS29252.1.
PIRiA40047.
RefSeqiNP_032934.1. NM_008908.4.
UniGeneiMm.4587.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2RMCX-ray1.64A/C/E/G31-212[»]
ProteinModelPortaliP30412.
SMRiP30412. Positions 31-212.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP30412. 3 interactions.
MINTiMINT-4108440.
STRINGi10090.ENSMUSP00000025419.

PTM databases

PhosphoSiteiP30412.

2D gel databases

REPRODUCTION-2DPAGEIPI00130240.

Proteomic databases

EPDiP30412.
PaxDbiP30412.
PeptideAtlasiP30412.
PRIDEiP30412.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000025419; ENSMUSP00000025419; ENSMUSG00000024538.
GeneIDi19038.
KEGGimmu:19038.
UCSCiuc008exu.1. mouse.

Organism-specific databases

CTDi5480.
MGIiMGI:97751. Ppic.

Phylogenomic databases

eggNOGiKOG0880. Eukaryota.
ENOG410Z0G4. LUCA.
HOGENOMiHOG000065981.
HOVERGENiHBG001065.
InParanoidiP30412.
KOiK09563.
OMAiDRPLTNC.
OrthoDBiEOG091G0BGL.
PhylomeDBiP30412.
TreeFamiTF354259.

Miscellaneous databases

ChiTaRSiPpic. mouse.
EvolutionaryTraceiP30412.
PROiP30412.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000024538.
CleanExiMM_PPIC.
ExpressionAtlasiP30412. baseline and differential.
GenevisibleiP30412. MM.

Family and domain databases

Gene3Di2.40.100.10. 1 hit.
InterProiIPR029000. Cyclophilin-like_dom.
IPR024936. Cyclophilin-type_PPIase.
IPR020892. Cyclophilin-type_PPIase_CS.
IPR002130. Cyclophilin-type_PPIase_dom.
[Graphical view]
PANTHERiPTHR11071. PTHR11071. 1 hit.
PfamiPF00160. Pro_isomerase. 1 hit.
[Graphical view]
PRINTSiPR00153. CSAPPISMRASE.
SUPFAMiSSF50891. SSF50891. 1 hit.
PROSITEiPS00170. CSA_PPIASE_1. 1 hit.
PS50072. CSA_PPIASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPPIC_MOUSE
AccessioniPrimary (citable) accession number: P30412
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: September 7, 2016
This is version 137 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.