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P30411

- BKRB2_HUMAN

UniProt

P30411 - BKRB2_HUMAN

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Protein

B2 bradykinin receptor

Gene

BDKRB2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Receptor for bradykinin. It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system.

GO - Molecular functioni

  1. bradykinin receptor activity Source: BHF-UCL
  2. phosphatidylinositol phospholipase C activity Source: ProtInc
  3. protease binding Source: BHF-UCL
  4. protein heterodimerization activity Source: BHF-UCL
  5. type 1 angiotensin receptor binding Source: BHF-UCL

GO - Biological processi

  1. arachidonic acid secretion Source: BHF-UCL
  2. blood circulation Source: ProtInc
  3. cell surface receptor signaling pathway Source: ProtInc
  4. G-protein coupled receptor signaling pathway Source: ProtInc
  5. inflammatory response Source: BHF-UCL
  6. metabolic process Source: GOC
  7. negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator Source: Ensembl
  8. negative regulation of peptidyl-serine phosphorylation Source: Ensembl
  9. positive regulation of cytosolic calcium ion concentration Source: ProtInc
  10. regulation of vascular permeability Source: BHF-UCL
  11. regulation of vasoconstriction Source: BHF-UCL
  12. response to salt stress Source: Ensembl
  13. smooth muscle contraction Source: BHF-UCL
  14. transmembrane receptor protein tyrosine kinase signaling pathway Source: ProtInc
  15. vasoconstriction Source: InterPro
  16. vasodilation Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_14819. Peptide ligand-binding receptors.
REACT_18283. G alpha (q) signalling events.
REACT_19231. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
B2 bradykinin receptor
Short name:
B2R
Short name:
BK-2 receptor
Gene namesi
Name:BDKRB2
Synonyms:BKR2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 14

Organism-specific databases

HGNCiHGNC:1030. BDKRB2.

Subcellular locationi

GO - Cellular componenti

  1. endosome Source: BHF-UCL
  2. integral component of plasma membrane Source: ProtInc
  3. plasma membrane Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA80.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 391391B2 bradykinin receptorPRO_0000069190Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi30 – 301N-linked (GlcNAc...)Sequence Analysis
Glycosylationi39 – 391N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi130 ↔ 211PROSITE-ProRule annotation
Modified residuei156 – 1561PhosphotyrosineBy similarity
Glycosylationi207 – 2071N-linked (GlcNAc...)Sequence Analysis
Modified residuei347 – 3471PhosphotyrosineBy similarity
Lipidationi351 – 3511S-palmitoyl cysteineSequence Analysis
Modified residuei366 – 3661PhosphoserineBy similarity
Modified residuei369 – 3691PhosphothreonineBy similarity
Modified residuei373 – 3731Phosphoserine; by GRK61 Publication
Modified residuei375 – 3751Phosphoserine; by GRK61 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

MaxQBiP30411.
PaxDbiP30411.
PRIDEiP30411.

PTM databases

PhosphoSiteiP30411.

Expressioni

Tissue specificityi

Ubiquitous. Widespread in normal smooth muscle tissue and neurons.1 Publication

Gene expression databases

BgeeiP30411.
CleanExiHS_BDKRB2.
GenevestigatoriP30411.

Organism-specific databases

HPAiHPA050841.

Interactioni

Subunit structurei

Forms a complex with PECAM1 and GNAQ. Interacts with PECAM1.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
KNG1P010422EBI-6623386,EBI-6623273

Protein-protein interaction databases

BioGridi107093. 4 interactions.
IntActiP30411. 1 interaction.
MINTiMINT-107081.
STRINGi9606.ENSP00000307713.

Structurei

3D structure databases

ProteinModelPortaliP30411.
SMRiP30411. Positions 61-341.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 6060ExtracellularSequence AnalysisAdd
BLAST
Topological domaini85 – 939CytoplasmicSequence Analysis
Topological domaini119 – 13113ExtracellularSequence AnalysisAdd
BLAST
Topological domaini154 – 17522CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini199 – 22123ExtracellularSequence AnalysisAdd
BLAST
Topological domaini249 – 26719CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini293 – 31119ExtracellularSequence AnalysisAdd
BLAST
Topological domaini336 – 39156CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei61 – 8424Helical; Name=1Sequence AnalysisAdd
BLAST
Transmembranei94 – 11825Helical; Name=2Sequence AnalysisAdd
BLAST
Transmembranei132 – 15322Helical; Name=3Sequence AnalysisAdd
BLAST
Transmembranei176 – 19823Helical; Name=4Sequence AnalysisAdd
BLAST
Transmembranei222 – 24827Helical; Name=5Sequence AnalysisAdd
BLAST
Transmembranei268 – 29225Helical; Name=6Sequence AnalysisAdd
BLAST
Transmembranei312 – 33524Helical; Name=7Sequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Bradykinin receptor subfamily. BDKRB2 sub-subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG148810.
GeneTreeiENSGT00760000119055.
HOGENOMiHOG000010314.
HOVERGENiHBG103183.
InParanoidiP30411.
KOiK03916.
OMAiHKSSCTV.
OrthoDBiEOG7HHWSV.
PhylomeDBiP30411.
TreeFamiTF330024.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR001504. Brdyknn_2_rcpt.
IPR000496. Brdyknn_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00425. BRADYKININR.
PR00994. BRADYKINNB2R.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform Long (identifier: P30411-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MFSPWKISMF LSVREDSVPT TASFSADMLN VTLQGPTLNG TFAQSKCPQV
60 70 80 90 100
EWLGWLNTIQ PPFLWVLFVL ATLENIFVLS VFCLHKSSCT VAEIYLGNLA
110 120 130 140 150
AADLILACGL PFWAITISNN FDWLFGETLC RVVNAIISMN LYSSICFLML
160 170 180 190 200
VSIDRYLALV KTMSMGRMRG VRWAKLYSLV IWGCTLLLSS PMLVFRTMKE
210 220 230 240 250
YSDEGHNVTA CVISYPSLIW EVFTNMLLNV VGFLLPLSVI TFCTMQIMQV
260 270 280 290 300
LRNNEMQKFK EIQTERRATV LVLVVLLLFI ICWLPFQIST FLDTLHRLGI
310 320 330 340 350
LSSCQDERII DVITQIASFM AYSNSCLNPL VYVIVGKRFR KKSWEVYQGV
360 370 380 390
CQKGGCRSEP IQMENSMGTL RTSISVERQI HKLQDWAGSR Q
Length:391
Mass (Da):44,461
Last modified:November 1, 1997 - v2
Checksum:i066940ED3D18BB66
GO
Isoform Short (identifier: P30411-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-27: Missing.

Show »
Length:364
Mass (Da):41,441
Checksum:i8FDC67EFC6600FB6
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti14 – 141R → C.2 Publications
Corresponds to variant rs1046248 [ dbSNP | Ensembl ].
VAR_003457
Natural varianti354 – 3541G → E.1 Publication
Corresponds to variant rs2227279 [ dbSNP | Ensembl ].
VAR_012284

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 2727Missing in isoform Short. 2 PublicationsVSP_001865Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M88714 mRNA. Translation: AAB02793.1.
S56772 Genomic DNA. Translation: AAB25765.1.
X69680 mRNA. Translation: CAA49360.1.
S45489 Genomic DNA. Translation: AAB23467.1.
L27594 Genomic DNA. No translation available.
X86165 mRNA. Translation: CAA60109.1.
X86164 mRNA. Translation: CAA60108.1.
AY275465 mRNA. Translation: AAP32297.1.
AF378542 Genomic DNA. Translation: AAK56376.1.
BC074894 mRNA. Translation: AAH74894.1.
BC074895 mRNA. Translation: AAH74895.1.
CCDSiCCDS9942.1. [P30411-1]
PIRiJH0712. JQ1488.
RefSeqiNP_000614.1. NM_000623.3. [P30411-1]
UniGeneiHs.654542.
Hs.726620.

Genome annotation databases

EnsembliENST00000539359; ENSP00000438376; ENSG00000168398. [P30411-2]
ENST00000542454; ENSP00000439459; ENSG00000168398. [P30411-2]
ENST00000554311; ENSP00000450482; ENSG00000168398. [P30411-1]
GeneIDi624.
KEGGihsa:624.
UCSCiuc001yfg.2. human. [P30411-1]

Polymorphism databases

DMDMi2506481.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Wikipedia

Bradykinin receptor entry

SeattleSNPs

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M88714 mRNA. Translation: AAB02793.1 .
S56772 Genomic DNA. Translation: AAB25765.1 .
X69680 mRNA. Translation: CAA49360.1 .
S45489 Genomic DNA. Translation: AAB23467.1 .
L27594 Genomic DNA. No translation available.
X86165 mRNA. Translation: CAA60109.1 .
X86164 mRNA. Translation: CAA60108.1 .
AY275465 mRNA. Translation: AAP32297.1 .
AF378542 Genomic DNA. Translation: AAK56376.1 .
BC074894 mRNA. Translation: AAH74894.1 .
BC074895 mRNA. Translation: AAH74895.1 .
CCDSi CCDS9942.1. [P30411-1 ]
PIRi JH0712. JQ1488.
RefSeqi NP_000614.1. NM_000623.3. [P30411-1 ]
UniGenei Hs.654542.
Hs.726620.

3D structure databases

ProteinModelPortali P30411.
SMRi P30411. Positions 61-341.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 107093. 4 interactions.
IntActi P30411. 1 interaction.
MINTi MINT-107081.
STRINGi 9606.ENSP00000307713.

Chemistry

BindingDBi P30411.
ChEMBLi CHEMBL3157.
DrugBanki DB06196. Icatibant.
GuidetoPHARMACOLOGYi 42.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei P30411.

Polymorphism databases

DMDMi 2506481.

Proteomic databases

MaxQBi P30411.
PaxDbi P30411.
PRIDEi P30411.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000539359 ; ENSP00000438376 ; ENSG00000168398 . [P30411-2 ]
ENST00000542454 ; ENSP00000439459 ; ENSG00000168398 . [P30411-2 ]
ENST00000554311 ; ENSP00000450482 ; ENSG00000168398 . [P30411-1 ]
GeneIDi 624.
KEGGi hsa:624.
UCSCi uc001yfg.2. human. [P30411-1 ]

Organism-specific databases

CTDi 624.
GeneCardsi GC14P096671.
HGNCi HGNC:1030. BDKRB2.
HPAi HPA050841.
MIMi 113503. gene.
neXtProti NX_P30411.
PharmGKBi PA80.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG148810.
GeneTreei ENSGT00760000119055.
HOGENOMi HOG000010314.
HOVERGENi HBG103183.
InParanoidi P30411.
KOi K03916.
OMAi HKSSCTV.
OrthoDBi EOG7HHWSV.
PhylomeDBi P30411.
TreeFami TF330024.

Enzyme and pathway databases

Reactomei REACT_14819. Peptide ligand-binding receptors.
REACT_18283. G alpha (q) signalling events.
REACT_19231. G alpha (i) signalling events.

Miscellaneous databases

ChiTaRSi BDKRB2. human.
GeneWikii Bradykinin_receptor_B2.
GenomeRNAii 624.
NextBioi 2522.
PROi P30411.
SOURCEi Search...

Gene expression databases

Bgeei P30411.
CleanExi HS_BDKRB2.
Genevestigatori P30411.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR001504. Brdyknn_2_rcpt.
IPR000496. Brdyknn_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view ]
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00425. BRADYKININR.
PR00994. BRADYKINNB2R.
PR00237. GPCRRHODOPSN.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and pharmacological characterization of a human bradykinin (BK-2) receptor."
    Hess J.F.R., Borkowski J.A., Young G.S., Strader C.D., Ransom R.W.
    Biochem. Biophys. Res. Commun. 184:260-268(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM SHORT).
  2. "Human bradykinin B2 receptor: nucleotide sequence analysis and assignment to chromosome 14."
    Powell S.J., Slynn G., Thomas C., Hopkins B., Briggs I., Graham A.
    Genomics 15:435-438(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM SHORT).
  3. "Cloned murine bradykinin receptor exhibits a mixed B1 and B2 pharmacological selectivity."
    McIntyre P., Phillips E., Skidmore E., Brown M., Webb M.
    Mol. Pharmacol. 44:346-355(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM SHORT).
  4. "Molecular cloning, functional expression and pharmacological characterization of a human bradykinin B2 receptor gene."
    Eggerickx D., Raspe E., Bertrand D., Vassart G., Parmentier M.
    Biochem. Biophys. Res. Commun. 187:1306-1313(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM SHORT).
  5. "Structure and chromosomal localization of the gene (BDKRB2) encoding human bradykinin B2 receptor."
    Ma J.-X., Wang D.-Z., Ward D.C., Chen L., Dessai T., Chao J., Chao L.
    Genomics 23:362-369(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM LONG), TISSUE SPECIFICITY.
  6. "Identification of polymorphic sites of the human bradykinin B2 receptor gene."
    Braun A., Kammerer S., Boehme E., Mueller B., Roscher A.A.
    Biochem. Biophys. Res. Commun. 211:234-240(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM LONG), VARIANT CYS-14.
  7. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
    Warren C.N., Aronstam R.S., Sharma S.V.
    Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM LONG).
    Tissue: Lung.
  8. SeattleSNPs variation discovery resource
    Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS CYS-14 AND GLU-354.
  9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM LONG).
    Tissue: Lung.
  10. Cited for: PROTEIN SEQUENCE OF 1-9 AND 17-30.
    Tissue: Foreskin.
  11. "Regulation of G protein-coupled receptor activities by the platelet-endothelial cell adhesion molecule, PECAM-1."
    Yeh J.C., Otte L.A., Frangos J.A.
    Biochemistry 47:9029-9039(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH PECAM1.
  12. "Determination of bradykinin B2 receptor in vivo phosphorylation sites and their role in receptor function."
    Blaukat A., Pizard A., Breit A., Wernstedt C., Alhenc-Gelas F., Muller-Esterl W., Dikic I.
    J. Biol. Chem. 276:40431-40440(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION AT SER-373 AND SER-375.

Entry informationi

Entry nameiBKRB2_HUMAN
AccessioniPrimary (citable) accession number: P30411
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: November 1, 1997
Last modified: October 29, 2014
This is version 154 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3