P30410 (INS_PANTR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Insulin

Cleaved into the following 2 chains:

1. Insulin B chain
2. Insulin A chain

Gene names

Name:

INS

Organism

Pan troglodytes (Chimpanzee) [Reference proteome]

Taxonomic identifier

9598 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Pan

Protein attributes

Sequence length	110 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.
Subunit structure	Heterodimer of a B chain and an A chain linked by two disulfide bonds.
Subcellular location	Secreted.
Sequence similarities	Belongs to the insulin family.

Ontologies

Keywords
Biological process	Carbohydrate metabolism Glucose metabolism
Cellular component	Secreted
Domain	Signal
Molecular function	Hormone
PTM	Cleavage on pair of basic residues Disulfide bond
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	G-protein coupled receptor signaling pathway Inferred from electronic annotation. Source: Compara MAPK cascade Inferred from electronic annotation. Source: Compara activation of protein kinase B activity Inferred from electronic annotation. Source: Compara acute-phase response Inferred from electronic annotation. Source: Compara alpha-beta T cell activation Inferred from electronic annotation. Source: Compara fatty acid homeostasis Inferred from electronic annotation. Source: Compara glucose homeostasis Inferred from electronic annotation. Source: Compara glucose metabolic process Inferred from electronic annotation. Source: UniProtKB-KW glucose transport Inferred from electronic annotation. Source: Compara negative regulation of NAD(P)H oxidase activity Inferred from electronic annotation. Source: Compara negative regulation of acute inflammatory response Inferred from electronic annotation. Source: Compara negative regulation of fatty acid metabolic process Inferred from electronic annotation. Source: Compara negative regulation of feeding behavior Inferred from electronic annotation. Source: Compara negative regulation of glycogen catabolic process Inferred from electronic annotation. Source: Compara negative regulation of protein catabolic process Inferred from electronic annotation. Source: Compara negative regulation of protein oligomerization Inferred from electronic annotation. Source: Compara negative regulation of protein secretion Inferred from electronic annotation. Source: Compara negative regulation of proteolysis Inferred from electronic annotation. Source: Compara negative regulation of respiratory burst involved in inflammatory response Inferred from electronic annotation. Source: Compara positive regulation of DNA replication Inferred from electronic annotation. Source: Compara positive regulation of MAPK cascade Inferred from electronic annotation. Source: Compara positive regulation of NF-kappaB transcription factor activity Inferred from electronic annotation. Source: Compara positive regulation of cell proliferation Inferred from electronic annotation. Source: Compara positive regulation of cytokine secretion Inferred from electronic annotation. Source: Compara positive regulation of glucose import Inferred from electronic annotation. Source: Compara positive regulation of glycogen biosynthetic process Inferred from electronic annotation. Source: Compara positive regulation of glycolysis Inferred from electronic annotation. Source: Compara positive regulation of insulin receptor signaling pathway Inferred from electronic annotation. Source: Compara positive regulation of mitosis Inferred from electronic annotation. Source: Compara positive regulation of peptidyl-tyrosine phosphorylation Inferred from electronic annotation. Source: Compara positive regulation of phosphatidylinositol 3-kinase cascade Inferred from electronic annotation. Source: Compara positive regulation of protein kinase B signaling cascade Inferred from electronic annotation. Source: Compara positive regulation of respiratory burst Inferred from electronic annotation. Source: Compara regulation of cellular amino acid metabolic process Inferred from electronic annotation. Source: Compara regulation of transmembrane transporter activity Inferred from electronic annotation. Source: Compara wound healing Inferred from electronic annotation. Source: Compara
Cellular_component	extracellular space Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 24

24

By similarity

Peptide

25 – 54

30

Insulin B chain

PRO_0000015870

Propeptide

57 – 87

31

C peptide

PRO_0000015871

Peptide

90 – 110

21

Insulin A chain

PRO_0000015872

Amino acid modifications

Disulfide bond

31 ↔ 96

Interchain (between B and A chains) By similarity

Disulfide bond

43 ↔ 109

Interchain (between B and A chains) By similarity

Disulfide bond

95 ↔ 100

By similarity

Secondary structure

1

.

.

.

.

110

Helix Strand Turn

Details...

Helix

33 – 43

11

Beta strand

44 – 46

3

Sequences

	Sequence		Length	Mass (Da)
	P30410 [UniParc]. Last modified April 1, 1993. Version 1. Checksum: 41EB8DF79837CEF5	FASTA	110	12,025
	10 20 30 40 50 60 MALWMRLLPL LVLLALWGPD PASAFVNQHL CGSHLVEALY LVCGERGFFY TPKTRREAED 70 80 90 100 110 LQVGQVELGG GPGAGSLQPL ALEGSLQKRG IVEQCCTSIC SLYQLENYCN

References

[1]	"Sequences of primate insulin genes support the hypothesis of a slower rate of molecular evolution in humans and apes than in monkeys." Seino S., Bell G.I., Li W. Mol. Biol. Evol. 9:193-203(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Global haplotype diversity in the human insulin gene region." Stead J.D.H., Hurles M.E., Jeffreys A.J. Genome Res. 13:2101-2111(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

X61089 Genomic DNA. Translation: CAA43403.1.
AY137497 Genomic DNA. Translation: AAN06933.1.

PIR

A42179.

RefSeq

NP_001008996.1. NM_001008996.2.

UniGene

Ptr.6479.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1BZV	NMR	-	B	25-49	[»]

ProteinModelPortal

P30410.

SMR

P30410. Positions 25-110.

ModBase

Search...

Protein-protein interaction databases

STRING

9598.ENSPTRP00000057962.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENSPTRT00000006075; ENSPTRP00000005606; ENSPTRG00000003172.

GeneID

449570.

KEGG

ptr:449570.

Organism-specific databases

CTD

3630.

Phylogenomic databases

eggNOG

NOG45999.

GeneTree

ENSGT00390000015440.

HOGENOM

HOG000261669.

HOVERGEN

HBG006137.

KO

K04526.

OMA

VEQCCHN.

Family and domain databases

Gene3D

1.10.100.10. 2 hits.

InterPro

IPR004825. Insulin.
IPR016179. Insulin-like.
IPR022353. Insulin_CS.
IPR022352. Insulin_family.
[Graphical view]

Pfam

PF00049. Insulin. 1 hit.
[Graphical view]

PRINTS

PR00277. INSULIN.
PR00276. INSULINFAMLY.

SMART

SM00078. IlGF. 1 hit.
[Graphical view]

SUPFAM

SSF56994. Insulin-like. 1 hit.

PROSITE

PS00262. INSULIN. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

EvolutionaryTrace

P30410.

NextBio

20832685.

Entry information

Entry name

INS_PANTR

Accession

Primary (citable) accession number: P30410

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 1, 1993
Last sequence update:	April 1, 1993
Last modified:	April 3, 2013
This is version 96 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program