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P30410

- INS_PANTR

UniProt

P30410 - INS_PANTR

Protein

Insulin

Gene

INS

Organism
Pan troglodytes (Chimpanzee)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.

    GO - Biological processi

    1. activation of protein kinase B activity Source: Ensembl
    2. acute-phase response Source: Ensembl
    3. alpha-beta T cell activation Source: Ensembl
    4. fatty acid homeostasis Source: Ensembl
    5. glucose homeostasis Source: Ensembl
    6. glucose metabolic process Source: UniProtKB-KW
    7. glucose transport Source: Ensembl
    8. G-protein coupled receptor signaling pathway Source: Ensembl
    9. MAPK cascade Source: Ensembl
    10. negative regulation of acute inflammatory response Source: Ensembl
    11. negative regulation of fatty acid metabolic process Source: Ensembl
    12. negative regulation of feeding behavior Source: Ensembl
    13. negative regulation of glycogen catabolic process Source: Ensembl
    14. negative regulation of NAD(P)H oxidase activity Source: Ensembl
    15. negative regulation of protein catabolic process Source: Ensembl
    16. negative regulation of protein oligomerization Source: Ensembl
    17. negative regulation of protein secretion Source: Ensembl
    18. negative regulation of proteolysis Source: Ensembl
    19. negative regulation of respiratory burst involved in inflammatory response Source: Ensembl
    20. positive regulation of cell proliferation Source: Ensembl
    21. positive regulation of cytokine secretion Source: Ensembl
    22. positive regulation of DNA replication Source: Ensembl
    23. positive regulation of glucose import Source: Ensembl
    24. positive regulation of glycogen biosynthetic process Source: Ensembl
    25. positive regulation of glycolytic process Source: Ensembl
    26. positive regulation of insulin receptor signaling pathway Source: Ensembl
    27. positive regulation of MAPK cascade Source: Ensembl
    28. positive regulation of mitosis Source: Ensembl
    29. positive regulation of NF-kappaB transcription factor activity Source: Ensembl
    30. positive regulation of peptidyl-tyrosine phosphorylation Source: Ensembl
    31. positive regulation of phosphatidylinositol 3-kinase signaling Source: Ensembl
    32. positive regulation of protein kinase B signaling Source: Ensembl
    33. positive regulation of respiratory burst Source: Ensembl
    34. regulation of cellular amino acid metabolic process Source: Ensembl
    35. regulation of transmembrane transporter activity Source: Ensembl
    36. wound healing Source: Ensembl

    Keywords - Molecular functioni

    Hormone

    Keywords - Biological processi

    Carbohydrate metabolism, Glucose metabolism

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Insulin
    Cleaved into the following 2 chains:
    Gene namesi
    Name:INS
    OrganismiPan troglodytes (Chimpanzee)
    Taxonomic identifieri9598 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePan
    ProteomesiUP000002277: Chromosome 11

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular space Source: Ensembl

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2424By similarityAdd
    BLAST
    Peptidei25 – 5430Insulin B chainPRO_0000015870Add
    BLAST
    Propeptidei57 – 8731C peptidePRO_0000015871Add
    BLAST
    Peptidei90 – 11021Insulin A chainPRO_0000015872Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi31 ↔ 96Interchain (between B and A chains)By similarity
    Disulfide bondi43 ↔ 109Interchain (between B and A chains)By similarity
    Disulfide bondi95 ↔ 100By similarity

    Keywords - PTMi

    Cleavage on pair of basic residues, Disulfide bond

    Interactioni

    Subunit structurei

    Heterodimer of a B chain and an A chain linked by two disulfide bonds.

    Protein-protein interaction databases

    STRINGi9598.ENSPTRP00000057962.

    Structurei

    Secondary structure

    1
    110
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi33 – 4311
    Beta strandi44 – 463

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1BZVNMR-B25-49[»]
    ProteinModelPortaliP30410.
    SMRiP30410. Positions 25-110.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP30410.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the insulin family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG45999.
    GeneTreeiENSGT00390000015440.
    HOGENOMiHOG000261669.
    HOVERGENiHBG006137.
    KOiK04526.
    OMAiHAKAIHA.
    OrthoDBiEOG7TF7CG.
    TreeFamiTF332820.

    Family and domain databases

    Gene3Di1.10.100.10. 2 hits.
    InterProiIPR004825. Insulin.
    IPR016179. Insulin-like.
    IPR022353. Insulin_CS.
    IPR022352. Insulin_family.
    [Graphical view]
    PfamiPF00049. Insulin. 1 hit.
    [Graphical view]
    PRINTSiPR00277. INSULIN.
    PR00276. INSULINFAMLY.
    SMARTiSM00078. IlGF. 1 hit.
    [Graphical view]
    SUPFAMiSSF56994. SSF56994. 1 hit.
    PROSITEiPS00262. INSULIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P30410-1 [UniParc]FASTAAdd to Basket

    « Hide

    MALWMRLLPL LVLLALWGPD PASAFVNQHL CGSHLVEALY LVCGERGFFY    50
    TPKTRREAED LQVGQVELGG GPGAGSLQPL ALEGSLQKRG IVEQCCTSIC 100
    SLYQLENYCN 110
    Length:110
    Mass (Da):12,025
    Last modified:April 1, 1993 - v1
    Checksum:i41EB8DF79837CEF5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X61089 Genomic DNA. Translation: CAA43403.1.
    AY137497 Genomic DNA. Translation: AAN06933.1.
    PIRiA42179.
    RefSeqiNP_001008996.1. NM_001008996.2.
    UniGeneiPtr.6479.

    Genome annotation databases

    EnsembliENSPTRT00000006075; ENSPTRP00000005606; ENSPTRG00000003172.
    GeneIDi449570.
    KEGGiptr:449570.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X61089 Genomic DNA. Translation: CAA43403.1 .
    AY137497 Genomic DNA. Translation: AAN06933.1 .
    PIRi A42179.
    RefSeqi NP_001008996.1. NM_001008996.2.
    UniGenei Ptr.6479.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1BZV NMR - B 25-49 [» ]
    ProteinModelPortali P30410.
    SMRi P30410. Positions 25-110.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9598.ENSPTRP00000057962.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSPTRT00000006075 ; ENSPTRP00000005606 ; ENSPTRG00000003172 .
    GeneIDi 449570.
    KEGGi ptr:449570.

    Organism-specific databases

    CTDi 3630.

    Phylogenomic databases

    eggNOGi NOG45999.
    GeneTreei ENSGT00390000015440.
    HOGENOMi HOG000261669.
    HOVERGENi HBG006137.
    KOi K04526.
    OMAi HAKAIHA.
    OrthoDBi EOG7TF7CG.
    TreeFami TF332820.

    Miscellaneous databases

    EvolutionaryTracei P30410.
    NextBioi 20832685.

    Family and domain databases

    Gene3Di 1.10.100.10. 2 hits.
    InterProi IPR004825. Insulin.
    IPR016179. Insulin-like.
    IPR022353. Insulin_CS.
    IPR022352. Insulin_family.
    [Graphical view ]
    Pfami PF00049. Insulin. 1 hit.
    [Graphical view ]
    PRINTSi PR00277. INSULIN.
    PR00276. INSULINFAMLY.
    SMARTi SM00078. IlGF. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56994. SSF56994. 1 hit.
    PROSITEi PS00262. INSULIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequences of primate insulin genes support the hypothesis of a slower rate of molecular evolution in humans and apes than in monkeys."
      Seino S., Bell G.I., Li W.
      Mol. Biol. Evol. 9:193-203(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Global haplotype diversity in the human insulin gene region."
      Stead J.D.H., Hurles M.E., Jeffreys A.J.
      Genome Res. 13:2101-2111(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

    Entry informationi

    Entry nameiINS_PANTR
    AccessioniPrimary (citable) accession number: P30410
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 1, 1993
    Last sequence update: April 1, 1993
    Last modified: October 1, 2014
    This is version 102 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3