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P30410

- INS_PANTR

UniProt

P30410 - INS_PANTR

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Protein
Insulin
Gene
INS
Organism
Pan troglodytes (Chimpanzee)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.

GO - Biological processi

  1. G-protein coupled receptor signaling pathway Source: Ensembl
  2. MAPK cascade Source: Ensembl
  3. activation of protein kinase B activity Source: Ensembl
  4. acute-phase response Source: Ensembl
  5. alpha-beta T cell activation Source: Ensembl
  6. fatty acid homeostasis Source: Ensembl
  7. glucose homeostasis Source: Ensembl
  8. glucose metabolic process Source: UniProtKB-KW
  9. glucose transport Source: Ensembl
  10. negative regulation of NAD(P)H oxidase activity Source: Ensembl
  11. negative regulation of acute inflammatory response Source: Ensembl
  12. negative regulation of fatty acid metabolic process Source: Ensembl
  13. negative regulation of feeding behavior Source: Ensembl
  14. negative regulation of glycogen catabolic process Source: Ensembl
  15. negative regulation of protein catabolic process Source: Ensembl
  16. negative regulation of protein oligomerization Source: Ensembl
  17. negative regulation of protein secretion Source: Ensembl
  18. negative regulation of proteolysis Source: Ensembl
  19. negative regulation of respiratory burst involved in inflammatory response Source: Ensembl
  20. positive regulation of DNA replication Source: Ensembl
  21. positive regulation of MAPK cascade Source: Ensembl
  22. positive regulation of NF-kappaB transcription factor activity Source: Ensembl
  23. positive regulation of cell proliferation Source: Ensembl
  24. positive regulation of cytokine secretion Source: Ensembl
  25. positive regulation of glucose import Source: Ensembl
  26. positive regulation of glycogen biosynthetic process Source: Ensembl
  27. positive regulation of glycolytic process Source: Ensembl
  28. positive regulation of insulin receptor signaling pathway Source: Ensembl
  29. positive regulation of mitosis Source: Ensembl
  30. positive regulation of peptidyl-tyrosine phosphorylation Source: Ensembl
  31. positive regulation of phosphatidylinositol 3-kinase signaling Source: Ensembl
  32. positive regulation of protein kinase B signaling Source: Ensembl
  33. positive regulation of respiratory burst Source: Ensembl
  34. regulation of cellular amino acid metabolic process Source: Ensembl
  35. regulation of transmembrane transporter activity Source: Ensembl
  36. wound healing Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Hormone

Keywords - Biological processi

Carbohydrate metabolism, Glucose metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Insulin
Cleaved into the following 2 chains:
Gene namesi
Name:INS
OrganismiPan troglodytes (Chimpanzee)
Taxonomic identifieri9598 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePan
ProteomesiUP000002277: Chromosome 11

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424 By similarity
Add
BLAST
Peptidei25 – 5430Insulin B chain
PRO_0000015870Add
BLAST
Propeptidei57 – 8731C peptide
PRO_0000015871Add
BLAST
Peptidei90 – 11021Insulin A chain
PRO_0000015872Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi31 ↔ 96Interchain (between B and A chains) By similarity
Disulfide bondi43 ↔ 109Interchain (between B and A chains) By similarity
Disulfide bondi95 ↔ 100 By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond

Interactioni

Subunit structurei

Heterodimer of a B chain and an A chain linked by two disulfide bonds.

Protein-protein interaction databases

STRINGi9598.ENSPTRP00000057962.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi33 – 4311
Beta strandi44 – 463

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1BZVNMR-B25-49[»]
ProteinModelPortaliP30410.
SMRiP30410. Positions 25-110.

Miscellaneous databases

EvolutionaryTraceiP30410.

Family & Domainsi

Sequence similaritiesi

Belongs to the insulin family.

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG45999.
GeneTreeiENSGT00390000015440.
HOGENOMiHOG000261669.
HOVERGENiHBG006137.
KOiK04526.
OMAiHAKAIHA.
OrthoDBiEOG7TF7CG.
TreeFamiTF332820.

Family and domain databases

Gene3Di1.10.100.10. 2 hits.
InterProiIPR004825. Insulin.
IPR016179. Insulin-like.
IPR022353. Insulin_CS.
IPR022352. Insulin_family.
[Graphical view]
PfamiPF00049. Insulin. 1 hit.
[Graphical view]
PRINTSiPR00277. INSULIN.
PR00276. INSULINFAMLY.
SMARTiSM00078. IlGF. 1 hit.
[Graphical view]
SUPFAMiSSF56994. SSF56994. 1 hit.
PROSITEiPS00262. INSULIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P30410-1 [UniParc]FASTAAdd to Basket

« Hide

MALWMRLLPL LVLLALWGPD PASAFVNQHL CGSHLVEALY LVCGERGFFY    50
TPKTRREAED LQVGQVELGG GPGAGSLQPL ALEGSLQKRG IVEQCCTSIC 100
SLYQLENYCN 110
Length:110
Mass (Da):12,025
Last modified:April 1, 1993 - v1
Checksum:i41EB8DF79837CEF5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X61089 Genomic DNA. Translation: CAA43403.1.
AY137497 Genomic DNA. Translation: AAN06933.1.
PIRiA42179.
RefSeqiNP_001008996.1. NM_001008996.2.
UniGeneiPtr.6479.

Genome annotation databases

EnsembliENSPTRT00000006075; ENSPTRP00000005606; ENSPTRG00000003172.
GeneIDi449570.
KEGGiptr:449570.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X61089 Genomic DNA. Translation: CAA43403.1 .
AY137497 Genomic DNA. Translation: AAN06933.1 .
PIRi A42179.
RefSeqi NP_001008996.1. NM_001008996.2.
UniGenei Ptr.6479.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1BZV NMR - B 25-49 [» ]
ProteinModelPortali P30410.
SMRi P30410. Positions 25-110.
ModBasei Search...

Protein-protein interaction databases

STRINGi 9598.ENSPTRP00000057962.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSPTRT00000006075 ; ENSPTRP00000005606 ; ENSPTRG00000003172 .
GeneIDi 449570.
KEGGi ptr:449570.

Organism-specific databases

CTDi 3630.

Phylogenomic databases

eggNOGi NOG45999.
GeneTreei ENSGT00390000015440.
HOGENOMi HOG000261669.
HOVERGENi HBG006137.
KOi K04526.
OMAi HAKAIHA.
OrthoDBi EOG7TF7CG.
TreeFami TF332820.

Miscellaneous databases

EvolutionaryTracei P30410.
NextBioi 20832685.

Family and domain databases

Gene3Di 1.10.100.10. 2 hits.
InterProi IPR004825. Insulin.
IPR016179. Insulin-like.
IPR022353. Insulin_CS.
IPR022352. Insulin_family.
[Graphical view ]
Pfami PF00049. Insulin. 1 hit.
[Graphical view ]
PRINTSi PR00277. INSULIN.
PR00276. INSULINFAMLY.
SMARTi SM00078. IlGF. 1 hit.
[Graphical view ]
SUPFAMi SSF56994. SSF56994. 1 hit.
PROSITEi PS00262. INSULIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Sequences of primate insulin genes support the hypothesis of a slower rate of molecular evolution in humans and apes than in monkeys."
    Seino S., Bell G.I., Li W.
    Mol. Biol. Evol. 9:193-203(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Global haplotype diversity in the human insulin gene region."
    Stead J.D.H., Hurles M.E., Jeffreys A.J.
    Genome Res. 13:2101-2111(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiINS_PANTR
AccessioniPrimary (citable) accession number: P30410
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: June 11, 2014
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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