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P30409 (CD9_CHLAE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 76. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
CD9 antigen
Alternative name(s):
27 kDa diphtheria toxin receptor-associated protein
Short name=DRAP27
CD_antigen=CD9
Gene names
Name:CD9
OrganismChlorocebus aethiops (Green monkey) (Cercopithecus aethiops)
Taxonomic identifier9534 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Cercopithecidae › Cercopithecinae › Chlorocebus

Protein attributes

Sequence length228 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Involved in platelet activation and aggregation. Regulates paranodal junction formation. Involved in cell adhesion, cell motility and tumor metastasis. Required for sperm-egg fusion By similarity.

Subunit structure

Forms both disulfide-linked homodimers and higher homooligomers as well as heterooligomers with other members of the tetraspanin family. Associates with CR2/CD21 and with PTGFRN/CD9P1. Interacts directly with IGSF8 By similarity.

Subcellular location

Membrane; Multi-pass membrane protein.

Post-translational modification

Phosphorylated on tyrosine following B-cell activation By similarity.

Sequence similarities

Belongs to the tetraspanin (TM4SF) family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 228227CD9 antigen
PRO_0000219203

Regions

Topological domain2 – 1211Cytoplasmic Potential
Transmembrane13 – 3321Helical; Potential
Topological domain34 – 5522Extracellular Potential
Transmembrane56 – 7621Helical; Potential
Topological domain77 – 8711Cytoplasmic Potential
Transmembrane88 – 11124Helical; Potential
Topological domain112 – 19584Extracellular Potential
Transmembrane196 – 22126Helical; Potential
Topological domain222 – 2287Cytoplasmic Potential

Amino acid modifications

Lipidation91S-palmitoyl cysteine By similarity
Lipidation781S-palmitoyl cysteine By similarity
Lipidation791S-palmitoyl cysteine By similarity
Lipidation871S-palmitoyl cysteine By similarity
Lipidation2181S-palmitoyl cysteine By similarity
Lipidation2191S-palmitoyl cysteine By similarity
Glycosylation521N-linked (GlcNAc...) Potential
Glycosylation531N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
P30409 [UniParc].

Last modified January 23, 2007. Version 2.
Checksum: FBE3298BAFAF6B7A

FASTA22825,431
        10         20         30         40         50         60 
MPVKGGTKCI KYLLFGFNFI FWLAGIAVLA IGLWLRFDSQ TKSIFEQETN NNNSSFYTGV 

        70         80         90        100        110        120 
YILIGAGALM MLVGFLGCCG AVQESQCMLG LFFGFLLVIF AIEIAAAIWG YSHKDEVIKE 

       130        140        150        160        170        180 
VQEFYKDTYN KLKTKDEPQR ETLKAIHYAL DCCGLAGGVE QFISDICPKK DVLETFTIKS 

       190        200        210        220 
CPDAIKEVFD NKFHIIGAVG IGIAVVMIFG MIFSMILCCA IRRNREMV

« Hide

References

[1]"The 27-kD diphtheria toxin receptor-associated protein (DRAP27) from vero cells is the monkey homologue of human CD9 antigen: expression of DRAP27 elevates the number of diphtheria toxin receptors on toxin-sensitive cells."
Mitamura T., Iwamoto R., Umata T., Yomo T., Urabe I., Tsuneoka M., Mekada E.
J. Cell Biol. 118:1389-1399(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		D10726 mRNA. Translation: BAA01569.1.
PIRA42929.

3D structure databases

ProteinModelPortalP30409.
ModBaseSearch...

Protein-protein interaction databases

DIPDIP-181N.
MINTMINT-232314.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

HOVERGENHBG002324.

Family and domain databases

InterProIPR000301. Tetraspanin.
IPR018499. Tetraspanin/Peripherin.
IPR018503. Tetraspanin_CS.
IPR008952. Tetraspanin_EC2.
[Graphical view]
PfamPF00335. Tetraspannin. 1 hit.
[Graphical view]
PIRSFPIRSF002419. Tetraspanin. 1 hit.
PRINTSPR00259. TMFOUR.
SUPFAMSSF48652. Tetraspanin. 1 hit.
PROSITEPS00421. TM4_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCD9_CHLAE
AccessionPrimary (citable) accession number: P30409
Entry history
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: January 23, 2007
Last modified: April 3, 2013
This is version 76 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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