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P30408

- T4S1_HUMAN

UniProt

P30408 - T4S1_HUMAN

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Protein

Transmembrane 4 L6 family member 1

Gene

TM4SF1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane 4 L6 family member 1
Alternative name(s):
Membrane component chromosome 3 surface marker 1
Tumor-associated antigen L6
Gene namesi
Name:TM4SF1
Synonyms:M3S1, TAAL6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 3

Organism-specific databases

HGNCiHGNC:11853. TM4SF1.

Subcellular locationi

GO - Cellular componenti

  1. integral component of plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA36554.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 202202Transmembrane 4 L6 family member 1PRO_0000219295Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi129 – 1291N-linked (GlcNAc...)Sequence Analysis
Glycosylationi159 – 1591N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiP30408.
PaxDbiP30408.
PRIDEiP30408.

Expressioni

Tissue specificityi

Highly expressed in lung, breast, colon and ovarian carcinomas. It is also present on some normal cells, endothelial cells in particular.

Gene expression databases

BgeeiP30408.
CleanExiHS_TM4SF1.
ExpressionAtlasiP30408. baseline and differential.
GenevestigatoriP30408.

Organism-specific databases

HPAiCAB002760.
HPA002823.

Interactioni

Subunit structurei

Present in high molecular weight complexes in tumor cells.

Protein-protein interaction databases

BioGridi110249. 6 interactions.
IntActiP30408. 5 interactions.
MINTiMINT-1371524.
STRINGi9606.ENSP00000304277.

Structurei

3D structure databases

ProteinModelPortaliP30408.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 99Cytoplasmic1 Publication
Topological domaini31 – 4919Extracellular1 PublicationAdd
BLAST
Topological domaini71 – 9323Cytoplasmic1 PublicationAdd
BLAST
Topological domaini115 – 16147Extracellular1 PublicationAdd
BLAST
Topological domaini183 – 20220Cytoplasmic1 PublicationAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei10 – 3021HelicalCuratedAdd
BLAST
Transmembranei50 – 7021HelicalCuratedAdd
BLAST
Transmembranei94 – 11421HelicalCuratedAdd
BLAST
Transmembranei162 – 18221HelicalCuratedAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the L6 tetraspanin family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG126713.
GeneTreeiENSGT00390000010992.
HOGENOMiHOG000030899.
HOVERGENiHBG000076.
InParanoidiP30408.
OMAiIGHSLVW.
OrthoDBiEOG7SN8DH.
PhylomeDBiP30408.
TreeFamiTF331371.

Family and domain databases

InterProiIPR008661. L6_membrane.
[Graphical view]
PfamiPF05805. L6_membrane. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P30408-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MCYGKCARCI GHSLVGLALL CIAANILLYF PNGETKYASE NHLSRFVWFF
60 70 80 90 100
SGIVGGGLLM LLPAFVFIGL EQDDCCGCCG HENCGKRCAM LSSVLAALIG
110 120 130 140 150
IAGSGYCVIV AALGLAEGPL CLDSLGQWNY TFASTEGQYL LDTSTWSECT
160 170 180 190 200
EPKHIVEWNV SLFSILLALG GIEFILCLIQ VINGVLGGIC GFCCSHQQQY

DC
Length:202
Mass (Da):21,632
Last modified:April 1, 1993 - v1
Checksum:i80D82C47902B8CD4
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M90657 mRNA. Translation: AAA36158.1.
CR456953 mRNA. Translation: CAG33234.1.
BC008442 mRNA. Translation: AAH08442.1.
BC010166 mRNA. Translation: AAH10166.1.
CCDSiCCDS3143.1.
PIRiA42926.
RefSeqiNP_055035.1. NM_014220.2.
UniGeneiHs.351316.

Genome annotation databases

EnsembliENST00000305366; ENSP00000304277; ENSG00000169908.
GeneIDi4071.
KEGGihsa:4071.
UCSCiuc003exb.1. human.

Polymorphism databases

DMDMi267068.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M90657 mRNA. Translation: AAA36158.1 .
CR456953 mRNA. Translation: CAG33234.1 .
BC008442 mRNA. Translation: AAH08442.1 .
BC010166 mRNA. Translation: AAH10166.1 .
CCDSi CCDS3143.1.
PIRi A42926.
RefSeqi NP_055035.1. NM_014220.2.
UniGenei Hs.351316.

3D structure databases

ProteinModelPortali P30408.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 110249. 6 interactions.
IntActi P30408. 5 interactions.
MINTi MINT-1371524.
STRINGi 9606.ENSP00000304277.

Polymorphism databases

DMDMi 267068.

Proteomic databases

MaxQBi P30408.
PaxDbi P30408.
PRIDEi P30408.

Protocols and materials databases

DNASUi 4071.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000305366 ; ENSP00000304277 ; ENSG00000169908 .
GeneIDi 4071.
KEGGi hsa:4071.
UCSCi uc003exb.1. human.

Organism-specific databases

CTDi 4071.
GeneCardsi GC03M149086.
HGNCi HGNC:11853. TM4SF1.
HPAi CAB002760.
HPA002823.
MIMi 191155. gene.
neXtProti NX_P30408.
PharmGKBi PA36554.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG126713.
GeneTreei ENSGT00390000010992.
HOGENOMi HOG000030899.
HOVERGENi HBG000076.
InParanoidi P30408.
OMAi IGHSLVW.
OrthoDBi EOG7SN8DH.
PhylomeDBi P30408.
TreeFami TF331371.

Miscellaneous databases

ChiTaRSi TM4SF1. human.
GeneWikii TM4SF1.
GenomeRNAii 4071.
NextBioi 15960.
PROi P30408.
SOURCEi Search...

Gene expression databases

Bgeei P30408.
CleanExi HS_TM4SF1.
ExpressionAtlasi P30408. baseline and differential.
Genevestigatori P30408.

Family and domain databases

InterProi IPR008661. L6_membrane.
[Graphical view ]
Pfami PF05805. L6_membrane. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Bone marrow and Lung.
  4. "Membrane topology of the L6 antigen and identification of the protein epitope recognized by the L6 monoclonal antibody."
    Marken J.S., Bajorath J., Edwards C.P., Farr A.G., Schieven G.L., Hellstroem I., Hellstroem K.E., Aruffo A.
    J. Biol. Chem. 269:7397-7401(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: TOPOLOGY.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiT4S1_HUMAN
AccessioniPrimary (citable) accession number: P30408
Secondary accession number(s): Q6IB51
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: October 29, 2014
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3