Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Transmembrane 4 L6 family member 1

Gene

TM4SF1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane 4 L6 family member 1
Alternative name(s):
Membrane component chromosome 3 surface marker 1
Tumor-associated antigen L6
Gene namesi
Name:TM4SF1
Synonyms:M3S1, TAAL6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:11853. TM4SF1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 99Cytoplasmic1 Publication
Transmembranei10 – 3021HelicalCuratedAdd
BLAST
Topological domaini31 – 4919Extracellular1 PublicationAdd
BLAST
Transmembranei50 – 7021HelicalCuratedAdd
BLAST
Topological domaini71 – 9323Cytoplasmic1 PublicationAdd
BLAST
Transmembranei94 – 11421HelicalCuratedAdd
BLAST
Topological domaini115 – 16147Extracellular1 PublicationAdd
BLAST
Transmembranei162 – 18221HelicalCuratedAdd
BLAST
Topological domaini183 – 20220Cytoplasmic1 PublicationAdd
BLAST

GO - Cellular componenti

  1. integral component of plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA36554.

Polymorphism and mutation databases

BioMutaiTM4SF1.
DMDMi267068.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 202202Transmembrane 4 L6 family member 1PRO_0000219295Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi129 – 1291N-linked (GlcNAc...)Sequence Analysis
Glycosylationi159 – 1591N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiP30408.
PaxDbiP30408.
PRIDEiP30408.

Expressioni

Tissue specificityi

Highly expressed in lung, breast, colon and ovarian carcinomas. It is also present on some normal cells, endothelial cells in particular.

Gene expression databases

BgeeiP30408.
CleanExiHS_TM4SF1.
ExpressionAtlasiP30408. baseline and differential.
GenevestigatoriP30408.

Organism-specific databases

HPAiCAB002760.
HPA002823.

Interactioni

Subunit structurei

Present in high molecular weight complexes in tumor cells.

Protein-protein interaction databases

BioGridi110249. 6 interactions.
IntActiP30408. 5 interactions.
MINTiMINT-1371524.
STRINGi9606.ENSP00000304277.

Structurei

3D structure databases

ProteinModelPortaliP30408.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the L6 tetraspanin family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG126713.
GeneTreeiENSGT00390000010992.
HOGENOMiHOG000030899.
HOVERGENiHBG000076.
InParanoidiP30408.
OMAiIGHSLVW.
OrthoDBiEOG7SN8DH.
PhylomeDBiP30408.
TreeFamiTF331371.

Family and domain databases

InterProiIPR008661. L6_membrane.
[Graphical view]
PfamiPF05805. L6_membrane. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P30408-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCYGKCARCI GHSLVGLALL CIAANILLYF PNGETKYASE NHLSRFVWFF
60 70 80 90 100
SGIVGGGLLM LLPAFVFIGL EQDDCCGCCG HENCGKRCAM LSSVLAALIG
110 120 130 140 150
IAGSGYCVIV AALGLAEGPL CLDSLGQWNY TFASTEGQYL LDTSTWSECT
160 170 180 190 200
EPKHIVEWNV SLFSILLALG GIEFILCLIQ VINGVLGGIC GFCCSHQQQY

DC
Length:202
Mass (Da):21,632
Last modified:April 1, 1993 - v1
Checksum:i80D82C47902B8CD4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M90657 mRNA. Translation: AAA36158.1.
CR456953 mRNA. Translation: CAG33234.1.
BC008442 mRNA. Translation: AAH08442.1.
BC010166 mRNA. Translation: AAH10166.1.
CCDSiCCDS3143.1.
PIRiA42926.
RefSeqiNP_055035.1. NM_014220.2.
UniGeneiHs.351316.

Genome annotation databases

EnsembliENST00000305366; ENSP00000304277; ENSG00000169908.
GeneIDi4071.
KEGGihsa:4071.
UCSCiuc003exb.1. human.

Polymorphism and mutation databases

BioMutaiTM4SF1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M90657 mRNA. Translation: AAA36158.1.
CR456953 mRNA. Translation: CAG33234.1.
BC008442 mRNA. Translation: AAH08442.1.
BC010166 mRNA. Translation: AAH10166.1.
CCDSiCCDS3143.1.
PIRiA42926.
RefSeqiNP_055035.1. NM_014220.2.
UniGeneiHs.351316.

3D structure databases

ProteinModelPortaliP30408.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110249. 6 interactions.
IntActiP30408. 5 interactions.
MINTiMINT-1371524.
STRINGi9606.ENSP00000304277.

Polymorphism and mutation databases

BioMutaiTM4SF1.
DMDMi267068.

Proteomic databases

MaxQBiP30408.
PaxDbiP30408.
PRIDEiP30408.

Protocols and materials databases

DNASUi4071.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000305366; ENSP00000304277; ENSG00000169908.
GeneIDi4071.
KEGGihsa:4071.
UCSCiuc003exb.1. human.

Organism-specific databases

CTDi4071.
GeneCardsiGC03M149086.
HGNCiHGNC:11853. TM4SF1.
HPAiCAB002760.
HPA002823.
MIMi191155. gene.
neXtProtiNX_P30408.
PharmGKBiPA36554.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG126713.
GeneTreeiENSGT00390000010992.
HOGENOMiHOG000030899.
HOVERGENiHBG000076.
InParanoidiP30408.
OMAiIGHSLVW.
OrthoDBiEOG7SN8DH.
PhylomeDBiP30408.
TreeFamiTF331371.

Miscellaneous databases

ChiTaRSiTM4SF1. human.
GeneWikiiTM4SF1.
GenomeRNAii4071.
NextBioi15960.
PROiP30408.
SOURCEiSearch...

Gene expression databases

BgeeiP30408.
CleanExiHS_TM4SF1.
ExpressionAtlasiP30408. baseline and differential.
GenevestigatoriP30408.

Family and domain databases

InterProiIPR008661. L6_membrane.
[Graphical view]
PfamiPF05805. L6_membrane. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Bone marrow and Lung.
  4. "Membrane topology of the L6 antigen and identification of the protein epitope recognized by the L6 monoclonal antibody."
    Marken J.S., Bajorath J., Edwards C.P., Farr A.G., Schieven G.L., Hellstroem I., Hellstroem K.E., Aruffo A.
    J. Biol. Chem. 269:7397-7401(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: TOPOLOGY.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiT4S1_HUMAN
AccessioniPrimary (citable) accession number: P30408
Secondary accession number(s): Q6IB51
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: April 29, 2015
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.