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Protein

Transmembrane 4 L6 family member 1

Gene

TM4SF1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane 4 L6 family member 1
Alternative name(s):
Membrane component chromosome 3 surface marker 1
Tumor-associated antigen L6
Gene namesi
Name:TM4SF1
Synonyms:M3S1, TAAL6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000169908.10
HGNCiHGNC:11853 TM4SF1
MIMi191155 gene
neXtProtiNX_P30408

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 9Cytoplasmic1 Publication9
Transmembranei10 – 30HelicalCuratedAdd BLAST21
Topological domaini31 – 49Extracellular1 PublicationAdd BLAST19
Transmembranei50 – 70HelicalCuratedAdd BLAST21
Topological domaini71 – 93Cytoplasmic1 PublicationAdd BLAST23
Transmembranei94 – 114HelicalCuratedAdd BLAST21
Topological domaini115 – 161Extracellular1 PublicationAdd BLAST47
Transmembranei162 – 182HelicalCuratedAdd BLAST21
Topological domaini183 – 202Cytoplasmic1 PublicationAdd BLAST20

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi202C → G: Abolishes interaction with SDCBP2. Loss of colocalization with SDCBP2 at the apical region of the cell. 1 Publication1

Organism-specific databases

DisGeNETi4071
OpenTargetsiENSG00000169908
PharmGKBiPA36554

Polymorphism and mutation databases

BioMutaiTM4SF1
DMDMi267068

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002192951 – 202Transmembrane 4 L6 family member 1Add BLAST202

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi129N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi159N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiP30408
PaxDbiP30408
PeptideAtlasiP30408
PRIDEiP30408

PTM databases

SwissPalmiP30408

Expressioni

Tissue specificityi

Highly expressed in lung, breast, colon and ovarian carcinomas. It is also present on some normal cells, endothelial cells in particular.

Gene expression databases

BgeeiENSG00000169908
CleanExiHS_TM4SF1
ExpressionAtlasiP30408 baseline and differential
GenevisibleiP30408 HS

Organism-specific databases

HPAiCAB002760
HPA002823

Interactioni

Subunit structurei

Present in high molecular weight complexes in tumor cells. Interacts with SDCBP2 (PubMed:11102519).1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
SDCBP2Q9H1903EBI-714256,EBI-742426

Protein-protein interaction databases

BioGridi1102496 interactors.
IntActiP30408 6 interactors.
STRINGi9606.ENSP00000304277

Structurei

3D structure databases

ProteinModelPortaliP30408
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the L6 tetraspanin family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IE1N Eukaryota
ENOG410YCUU LUCA
GeneTreeiENSGT00390000010992
HOGENOMiHOG000030899
HOVERGENiHBG000076
InParanoidiP30408
OMAiCYGRCAR
PhylomeDBiP30408
TreeFamiTF331371

Family and domain databases

InterProiView protein in InterPro
IPR008661 L6_membrane
PANTHERiPTHR14198 PTHR14198, 1 hit
PfamiView protein in Pfam
PF05805 L6_membrane, 1 hit

Sequencei

Sequence statusi: Complete.

P30408-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCYGKCARCI GHSLVGLALL CIAANILLYF PNGETKYASE NHLSRFVWFF
60 70 80 90 100
SGIVGGGLLM LLPAFVFIGL EQDDCCGCCG HENCGKRCAM LSSVLAALIG
110 120 130 140 150
IAGSGYCVIV AALGLAEGPL CLDSLGQWNY TFASTEGQYL LDTSTWSECT
160 170 180 190 200
EPKHIVEWNV SLFSILLALG GIEFILCLIQ VINGVLGGIC GFCCSHQQQY

DC
Length:202
Mass (Da):21,632
Last modified:April 1, 1993 - v1
Checksum:i80D82C47902B8CD4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M90657 mRNA Translation: AAA36158.1
CR456953 mRNA Translation: CAG33234.1
BC008442 mRNA Translation: AAH08442.1
BC010166 mRNA Translation: AAH10166.1
CCDSiCCDS3143.1
PIRiA42926
RefSeqiNP_055035.1, NM_014220.2
UniGeneiHs.351316

Genome annotation databases

EnsembliENST00000305366; ENSP00000304277; ENSG00000169908
GeneIDi4071
KEGGihsa:4071
UCSCiuc003exb.2 human

Similar proteinsi

Entry informationi

Entry nameiT4S1_HUMAN
AccessioniPrimary (citable) accession number: P30408
Secondary accession number(s): Q6IB51
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: March 28, 2018
This is version 136 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome