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P30408 (T4S1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 110. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Transmembrane 4 L6 family member 1
Alternative name(s):
Membrane component chromosome 3 surface marker 1
Tumor-associated antigen L6
Gene names
Name:TM4SF1
Synonyms:M3S1, TAAL6
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length202 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Subunit structure

Present in high molecular weight complexes in tumor cells.

Subcellular location

Membrane; Multi-pass membrane protein.

Tissue specificity

Highly expressed in lung, breast, colon and ovarian carcinomas. It is also present on some normal cells, endothelial cells in particular.

Sequence similarities

Belongs to the L6 tetraspanin family.

Ontologies

Keywords
   Cellular componentMembrane
   DomainTransmembrane
Transmembrane helix
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentintegral component of plasma membrane

Inferred from direct assay Ref.4. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 202202Transmembrane 4 L6 family member 1
PRO_0000219295

Regions

Topological domain1 – 99Cytoplasmic Probable
Transmembrane10 – 3021Helical; Probable
Topological domain31 – 4919Extracellular Probable
Transmembrane50 – 7021Helical; Probable
Topological domain71 – 9323Cytoplasmic Probable
Transmembrane94 – 11421Helical; Probable
Topological domain115 – 16147Extracellular Probable
Transmembrane162 – 18221Helical; Probable
Topological domain183 – 20220Cytoplasmic Probable

Amino acid modifications

Glycosylation1291N-linked (GlcNAc...) Potential
Glycosylation1591N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
P30408 [UniParc].

Last modified April 1, 1993. Version 1.
Checksum: 80D82C47902B8CD4

FASTA20221,632
        10         20         30         40         50         60 
MCYGKCARCI GHSLVGLALL CIAANILLYF PNGETKYASE NHLSRFVWFF SGIVGGGLLM 

        70         80         90        100        110        120 
LLPAFVFIGL EQDDCCGCCG HENCGKRCAM LSSVLAALIG IAGSGYCVIV AALGLAEGPL 

       130        140        150        160        170        180 
CLDSLGQWNY TFASTEGQYL LDTSTWSECT EPKHIVEWNV SLFSILLALG GIEFILCLIQ 

       190        200 
VINGVLGGIC GFCCSHQQQY DC 

« Hide

References

« Hide 'large scale' references
[1]"Cloning and expression of the tumor-associated antigen L6."
Marken J.S., Schieven G.L., Hellstroem I., Hellstroem K.E., Aruffo A.
Proc. Natl. Acad. Sci. U.S.A. 89:3503-3507(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Bone marrow and Lung.
[4]"Membrane topology of the L6 antigen and identification of the protein epitope recognized by the L6 monoclonal antibody."
Marken J.S., Bajorath J., Edwards C.P., Farr A.G., Schieven G.L., Hellstroem I., Hellstroem K.E., Aruffo A.
J. Biol. Chem. 269:7397-7401(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: TOPOLOGY.
[5]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M90657 mRNA. Translation: AAA36158.1.
CR456953 mRNA. Translation: CAG33234.1.
BC008442 mRNA. Translation: AAH08442.1.
BC010166 mRNA. Translation: AAH10166.1.
PIRA42926.
RefSeqNP_055035.1. NM_014220.2.
UniGeneHs.351316.

3D structure databases

ProteinModelPortalP30408.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid110249. 6 interactions.
IntActP30408. 5 interactions.
MINTMINT-1371524.
STRING9606.ENSP00000304277.

Polymorphism databases

DMDM267068.

Proteomic databases

PaxDbP30408.
PRIDEP30408.

Protocols and materials databases

DNASU4071.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000305366; ENSP00000304277; ENSG00000169908.
GeneID4071.
KEGGhsa:4071.
UCSCuc003exb.1. human.

Organism-specific databases

CTD4071.
GeneCardsGC03M149086.
HGNCHGNC:11853. TM4SF1.
HPACAB002760.
HPA002823.
MIM191155. gene.
neXtProtNX_P30408.
PharmGKBPA36554.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG126713.
HOGENOMHOG000030899.
HOVERGENHBG000076.
OMAIGHSLVW.
OrthoDBEOG7SN8DH.
PhylomeDBP30408.
TreeFamTF331371.

Gene expression databases

ArrayExpressP30408.
BgeeP30408.
CleanExHS_TM4SF1.
GenevestigatorP30408.

Family and domain databases

InterProIPR008661. L6_membrane.
[Graphical view]
PfamPF05805. L6_membrane. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSTM4SF1. human.
GeneWikiTM4SF1.
GenomeRNAi4071.
NextBio15960.
PROP30408.
SOURCESearch...

Entry information

Entry nameT4S1_HUMAN
AccessionPrimary (citable) accession number: P30408
Secondary accession number(s): Q6IB51
Entry history
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: February 19, 2014
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 3

Human chromosome 3: entries, gene names and cross-references to MIM