Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P30408

- T4S1_HUMAN

UniProt

P30408 - T4S1_HUMAN

Protein

Transmembrane 4 L6 family member 1

Gene

TM4SF1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 113 (01 Oct 2014)
      Sequence version 1 (01 Apr 1993)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Transmembrane 4 L6 family member 1
    Alternative name(s):
    Membrane component chromosome 3 surface marker 1
    Tumor-associated antigen L6
    Gene namesi
    Name:TM4SF1
    Synonyms:M3S1, TAAL6
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 3

    Organism-specific databases

    HGNCiHGNC:11853. TM4SF1.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of plasma membrane Source: UniProtKB

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA36554.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 202202Transmembrane 4 L6 family member 1PRO_0000219295Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi129 – 1291N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi159 – 1591N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    MaxQBiP30408.
    PaxDbiP30408.
    PRIDEiP30408.

    Expressioni

    Tissue specificityi

    Highly expressed in lung, breast, colon and ovarian carcinomas. It is also present on some normal cells, endothelial cells in particular.

    Gene expression databases

    ArrayExpressiP30408.
    BgeeiP30408.
    CleanExiHS_TM4SF1.
    GenevestigatoriP30408.

    Organism-specific databases

    HPAiCAB002760.
    HPA002823.

    Interactioni

    Subunit structurei

    Present in high molecular weight complexes in tumor cells.

    Protein-protein interaction databases

    BioGridi110249. 6 interactions.
    IntActiP30408. 5 interactions.
    MINTiMINT-1371524.
    STRINGi9606.ENSP00000304277.

    Structurei

    3D structure databases

    ProteinModelPortaliP30408.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 99Cytoplasmic1 Publication
    Topological domaini31 – 4919Extracellular1 PublicationAdd
    BLAST
    Topological domaini71 – 9323Cytoplasmic1 PublicationAdd
    BLAST
    Topological domaini115 – 16147Extracellular1 PublicationAdd
    BLAST
    Topological domaini183 – 20220Cytoplasmic1 PublicationAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei10 – 3021HelicalCuratedAdd
    BLAST
    Transmembranei50 – 7021HelicalCuratedAdd
    BLAST
    Transmembranei94 – 11421HelicalCuratedAdd
    BLAST
    Transmembranei162 – 18221HelicalCuratedAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the L6 tetraspanin family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG126713.
    HOGENOMiHOG000030899.
    HOVERGENiHBG000076.
    OMAiIGHSLVW.
    OrthoDBiEOG7SN8DH.
    PhylomeDBiP30408.
    TreeFamiTF331371.

    Family and domain databases

    InterProiIPR008661. L6_membrane.
    [Graphical view]
    PfamiPF05805. L6_membrane. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P30408-1 [UniParc]FASTAAdd to Basket

    « Hide

    MCYGKCARCI GHSLVGLALL CIAANILLYF PNGETKYASE NHLSRFVWFF    50
    SGIVGGGLLM LLPAFVFIGL EQDDCCGCCG HENCGKRCAM LSSVLAALIG 100
    IAGSGYCVIV AALGLAEGPL CLDSLGQWNY TFASTEGQYL LDTSTWSECT 150
    EPKHIVEWNV SLFSILLALG GIEFILCLIQ VINGVLGGIC GFCCSHQQQY 200
    DC 202
    Length:202
    Mass (Da):21,632
    Last modified:April 1, 1993 - v1
    Checksum:i80D82C47902B8CD4
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M90657 mRNA. Translation: AAA36158.1.
    CR456953 mRNA. Translation: CAG33234.1.
    BC008442 mRNA. Translation: AAH08442.1.
    BC010166 mRNA. Translation: AAH10166.1.
    CCDSiCCDS3143.1.
    PIRiA42926.
    RefSeqiNP_055035.1. NM_014220.2.
    UniGeneiHs.351316.

    Genome annotation databases

    EnsembliENST00000305366; ENSP00000304277; ENSG00000169908.
    GeneIDi4071.
    KEGGihsa:4071.
    UCSCiuc003exb.1. human.

    Polymorphism databases

    DMDMi267068.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M90657 mRNA. Translation: AAA36158.1 .
    CR456953 mRNA. Translation: CAG33234.1 .
    BC008442 mRNA. Translation: AAH08442.1 .
    BC010166 mRNA. Translation: AAH10166.1 .
    CCDSi CCDS3143.1.
    PIRi A42926.
    RefSeqi NP_055035.1. NM_014220.2.
    UniGenei Hs.351316.

    3D structure databases

    ProteinModelPortali P30408.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 110249. 6 interactions.
    IntActi P30408. 5 interactions.
    MINTi MINT-1371524.
    STRINGi 9606.ENSP00000304277.

    Polymorphism databases

    DMDMi 267068.

    Proteomic databases

    MaxQBi P30408.
    PaxDbi P30408.
    PRIDEi P30408.

    Protocols and materials databases

    DNASUi 4071.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000305366 ; ENSP00000304277 ; ENSG00000169908 .
    GeneIDi 4071.
    KEGGi hsa:4071.
    UCSCi uc003exb.1. human.

    Organism-specific databases

    CTDi 4071.
    GeneCardsi GC03M149086.
    HGNCi HGNC:11853. TM4SF1.
    HPAi CAB002760.
    HPA002823.
    MIMi 191155. gene.
    neXtProti NX_P30408.
    PharmGKBi PA36554.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG126713.
    HOGENOMi HOG000030899.
    HOVERGENi HBG000076.
    OMAi IGHSLVW.
    OrthoDBi EOG7SN8DH.
    PhylomeDBi P30408.
    TreeFami TF331371.

    Miscellaneous databases

    ChiTaRSi TM4SF1. human.
    GeneWikii TM4SF1.
    GenomeRNAii 4071.
    NextBioi 15960.
    PROi P30408.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P30408.
    Bgeei P30408.
    CleanExi HS_TM4SF1.
    Genevestigatori P30408.

    Family and domain databases

    InterProi IPR008661. L6_membrane.
    [Graphical view ]
    Pfami PF05805. L6_membrane. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Bone marrow and Lung.
    4. "Membrane topology of the L6 antigen and identification of the protein epitope recognized by the L6 monoclonal antibody."
      Marken J.S., Bajorath J., Edwards C.P., Farr A.G., Schieven G.L., Hellstroem I., Hellstroem K.E., Aruffo A.
      J. Biol. Chem. 269:7397-7401(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: TOPOLOGY.
    5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiT4S1_HUMAN
    AccessioniPrimary (citable) accession number: P30408
    Secondary accession number(s): Q6IB51
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 1, 1993
    Last sequence update: April 1, 1993
    Last modified: October 1, 2014
    This is version 113 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 3
      Human chromosome 3: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3