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Protein

Transmembrane 4 L6 family member 1

Gene

TM4SF1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Enzyme and pathway databases

BioCyciZFISH:ENSG00000169908-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane 4 L6 family member 1
Alternative name(s):
Membrane component chromosome 3 surface marker 1
Tumor-associated antigen L6
Gene namesi
Name:TM4SF1
Synonyms:M3S1, TAAL6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:11853. TM4SF1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 9Cytoplasmic1 Publication9
Transmembranei10 – 30HelicalCuratedAdd BLAST21
Topological domaini31 – 49Extracellular1 PublicationAdd BLAST19
Transmembranei50 – 70HelicalCuratedAdd BLAST21
Topological domaini71 – 93Cytoplasmic1 PublicationAdd BLAST23
Transmembranei94 – 114HelicalCuratedAdd BLAST21
Topological domaini115 – 161Extracellular1 PublicationAdd BLAST47
Transmembranei162 – 182HelicalCuratedAdd BLAST21
Topological domaini183 – 202Cytoplasmic1 PublicationAdd BLAST20

GO - Cellular componenti

  • integral component of plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi4071.
OpenTargetsiENSG00000169908.
PharmGKBiPA36554.

Polymorphism and mutation databases

BioMutaiTM4SF1.
DMDMi267068.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002192951 – 202Transmembrane 4 L6 family member 1Add BLAST202

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi129N-linked (GlcNAc...)Sequence analysis1
Glycosylationi159N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiP30408.
PaxDbiP30408.
PeptideAtlasiP30408.
PRIDEiP30408.

PTM databases

SwissPalmiP30408.

Expressioni

Tissue specificityi

Highly expressed in lung, breast, colon and ovarian carcinomas. It is also present on some normal cells, endothelial cells in particular.

Gene expression databases

BgeeiENSG00000169908.
CleanExiHS_TM4SF1.
ExpressionAtlasiP30408. baseline and differential.
GenevisibleiP30408. HS.

Organism-specific databases

HPAiCAB002760.
HPA002823.

Interactioni

Subunit structurei

Present in high molecular weight complexes in tumor cells.

Protein-protein interaction databases

BioGridi110249. 5 interactors.
IntActiP30408. 5 interactors.
MINTiMINT-1371524.
STRINGi9606.ENSP00000304277.

Structurei

3D structure databases

ProteinModelPortaliP30408.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the L6 tetraspanin family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IE1N. Eukaryota.
ENOG410YCUU. LUCA.
GeneTreeiENSGT00390000010992.
HOGENOMiHOG000030899.
HOVERGENiHBG000076.
InParanoidiP30408.
PhylomeDBiP30408.
TreeFamiTF331371.

Family and domain databases

InterProiIPR008661. L6_membrane.
[Graphical view]
PfamiPF05805. L6_membrane. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P30408-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCYGKCARCI GHSLVGLALL CIAANILLYF PNGETKYASE NHLSRFVWFF
60 70 80 90 100
SGIVGGGLLM LLPAFVFIGL EQDDCCGCCG HENCGKRCAM LSSVLAALIG
110 120 130 140 150
IAGSGYCVIV AALGLAEGPL CLDSLGQWNY TFASTEGQYL LDTSTWSECT
160 170 180 190 200
EPKHIVEWNV SLFSILLALG GIEFILCLIQ VINGVLGGIC GFCCSHQQQY

DC
Length:202
Mass (Da):21,632
Last modified:April 1, 1993 - v1
Checksum:i80D82C47902B8CD4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M90657 mRNA. Translation: AAA36158.1.
CR456953 mRNA. Translation: CAG33234.1.
BC008442 mRNA. Translation: AAH08442.1.
BC010166 mRNA. Translation: AAH10166.1.
CCDSiCCDS3143.1.
PIRiA42926.
RefSeqiNP_055035.1. NM_014220.2.
UniGeneiHs.351316.

Genome annotation databases

EnsembliENST00000305366; ENSP00000304277; ENSG00000169908.
GeneIDi4071.
KEGGihsa:4071.
UCSCiuc003exb.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M90657 mRNA. Translation: AAA36158.1.
CR456953 mRNA. Translation: CAG33234.1.
BC008442 mRNA. Translation: AAH08442.1.
BC010166 mRNA. Translation: AAH10166.1.
CCDSiCCDS3143.1.
PIRiA42926.
RefSeqiNP_055035.1. NM_014220.2.
UniGeneiHs.351316.

3D structure databases

ProteinModelPortaliP30408.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110249. 5 interactors.
IntActiP30408. 5 interactors.
MINTiMINT-1371524.
STRINGi9606.ENSP00000304277.

PTM databases

SwissPalmiP30408.

Polymorphism and mutation databases

BioMutaiTM4SF1.
DMDMi267068.

Proteomic databases

MaxQBiP30408.
PaxDbiP30408.
PeptideAtlasiP30408.
PRIDEiP30408.

Protocols and materials databases

DNASUi4071.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000305366; ENSP00000304277; ENSG00000169908.
GeneIDi4071.
KEGGihsa:4071.
UCSCiuc003exb.2. human.

Organism-specific databases

CTDi4071.
DisGeNETi4071.
GeneCardsiTM4SF1.
HGNCiHGNC:11853. TM4SF1.
HPAiCAB002760.
HPA002823.
MIMi191155. gene.
neXtProtiNX_P30408.
OpenTargetsiENSG00000169908.
PharmGKBiPA36554.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IE1N. Eukaryota.
ENOG410YCUU. LUCA.
GeneTreeiENSGT00390000010992.
HOGENOMiHOG000030899.
HOVERGENiHBG000076.
InParanoidiP30408.
PhylomeDBiP30408.
TreeFamiTF331371.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000169908-MONOMER.

Miscellaneous databases

ChiTaRSiTM4SF1. human.
GeneWikiiTM4SF1.
GenomeRNAii4071.
PROiP30408.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000169908.
CleanExiHS_TM4SF1.
ExpressionAtlasiP30408. baseline and differential.
GenevisibleiP30408. HS.

Family and domain databases

InterProiIPR008661. L6_membrane.
[Graphical view]
PfamiPF05805. L6_membrane. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiT4S1_HUMAN
AccessioniPrimary (citable) accession number: P30408
Secondary accession number(s): Q6IB51
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: November 2, 2016
This is version 128 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.