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Protein

Serine/threonine-protein phosphatase PP1 isozyme 1

Gene

TOPP1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Mn2+By similarityNote: Binds 2 manganese ions per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi77 – 771Manganese 1By similarity
Metal bindingi79 – 791Manganese 1By similarity
Metal bindingi105 – 1051Manganese 1By similarity
Metal bindingi105 – 1051Manganese 2By similarity
Metal bindingi137 – 1371Manganese 2By similarity
Active sitei138 – 1381Proton donorBy similarity
Metal bindingi186 – 1861Manganese 2By similarity
Metal bindingi260 – 2601Manganese 2By similarity

GO - Molecular functioni

  • metal ion binding Source: UniProtKB-KW
  • protein serine/threonine phosphatase activity Source: TAIR
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Ligandi

Manganese, Metal-binding

Enzyme and pathway databases

BioCyciARA:AT2G29400-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein phosphatase PP1 isozyme 1 (EC:3.1.3.16)
Gene namesi
Name:TOPP1
Synonyms:PP1
Ordered Locus Names:At2g29400
ORF Names:F16P2.22
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548 Componenti: Chromosome 2

Organism-specific databases

TAIRiAT2G29400.

Subcellular locationi

GO - Cellular componenti

  • protein phosphatase type 1 complex Source: TAIR
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 318317Serine/threonine-protein phosphatase PP1 isozyme 1PRO_0000058797Add
BLAST

Proteomic databases

PaxDbiP30366.
PRIDEiP30366.

Interactioni

Protein-protein interaction databases

BioGridi2839. 1 interaction.
IntActiP30366. 1 interaction.
STRINGi3702.AT2G29400.1.

Structurei

3D structure databases

ProteinModelPortaliP30366.
SMRiP30366. Positions 20-310.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PPP phosphatase family. PP-1 subfamily.Curated

Phylogenomic databases

eggNOGiCOG0639.
HOGENOMiHOG000172697.
InParanoidiP30366.
KOiK06269.
OMAiRNIARPM.
PhylomeDBiP30366.

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
InterProiIPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
IPR006186. Ser/Thr-sp_prot-phosphatase.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
PRINTSiPR00114. STPHPHTASE.
SMARTiSM00156. PP2Ac. 1 hit.
[Graphical view]
SUPFAMiSSF56300. SSF56300. 1 hit.
PROSITEiPS00125. SER_THR_PHOSPHATASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P30366-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEKPAQEQE QKRAMEPAVL DDIIRRLVEF RNTRPGSGKQ VHLSEGEIRQ
60 70 80 90 100
LCAVSKEIFL QQPNLLELEA PIKICGDIHG QYSDLLRLFE YGGFPPEANY
110 120 130 140 150
LFLGDYVDRG KQSLETICLL LAYKIKYPEN FFLLRGNHES ASINRIYGFY
160 170 180 190 200
DECKRRFNVR LWKIFTDCFN CLPVAALIDD RILCMHGGIS PELKSLDQIR
210 220 230 240 250
NIARPMDIPE SGLVCDLLWS DPSGDVGWGM NDRGVSYTFG ADKVAEFLEK
260 270 280 290 300
HDMDLICRAH QVVEDGYEFF AERQLVTVFS APNYCGEFDN AGAMMSIDES
310
LMCSFQILKP SEKKSPFL
Length:318
Mass (Da):36,279
Last modified:April 1, 1993 - v1
Checksum:iDAAA11674B148294
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X64328 mRNA. Translation: CAA45611.1.
M93408 mRNA. Translation: AAA32723.1.
AC004561 Genomic DNA. Translation: AAC95198.1.
CP002685 Genomic DNA. Translation: AEC08250.1.
AY080871 mRNA. Translation: AAL87342.1.
AY142593 mRNA. Translation: AAN13162.1.
PIRiS20882.
RefSeqiNP_180501.1. NM_128494.4.
UniGeneiAt.282.

Genome annotation databases

EnsemblPlantsiAT2G29400.1; AT2G29400.1; AT2G29400.
GeneIDi817489.
KEGGiath:AT2G29400.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X64328 mRNA. Translation: CAA45611.1.
M93408 mRNA. Translation: AAA32723.1.
AC004561 Genomic DNA. Translation: AAC95198.1.
CP002685 Genomic DNA. Translation: AEC08250.1.
AY080871 mRNA. Translation: AAL87342.1.
AY142593 mRNA. Translation: AAN13162.1.
PIRiS20882.
RefSeqiNP_180501.1. NM_128494.4.
UniGeneiAt.282.

3D structure databases

ProteinModelPortaliP30366.
SMRiP30366. Positions 20-310.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi2839. 1 interaction.
IntActiP30366. 1 interaction.
STRINGi3702.AT2G29400.1.

Proteomic databases

PaxDbiP30366.
PRIDEiP30366.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT2G29400.1; AT2G29400.1; AT2G29400.
GeneIDi817489.
KEGGiath:AT2G29400.

Organism-specific databases

TAIRiAT2G29400.

Phylogenomic databases

eggNOGiCOG0639.
HOGENOMiHOG000172697.
InParanoidiP30366.
KOiK06269.
OMAiRNIARPM.
PhylomeDBiP30366.

Enzyme and pathway databases

BioCyciARA:AT2G29400-MONOMER.

Miscellaneous databases

PROiP30366.

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
InterProiIPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
IPR006186. Ser/Thr-sp_prot-phosphatase.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
PRINTSiPR00114. STPHPHTASE.
SMARTiSM00156. PP2Ac. 1 hit.
[Graphical view]
SUPFAMiSSF56300. SSF56300. 1 hit.
PROSITEiPS00125. SER_THR_PHOSPHATASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complementation of the cs dis2-11 cell cycle mutant of Schizosaccharomyces pombe by a protein phosphatase from Arabidopsis thaliana."
    Nitschke K., Fleig U., Schell J., Palme K.
    EMBO J. 11:1327-1333(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: cv. Columbia.
  2. "Expression of multiple type 1 phosphoprotein phosphatases in Arabidopsis thaliana."
    Smith R.D., Walker J.C.
    Plant Mol. Biol. 21:307-316(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  4. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  5. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
    Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
    , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
    Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  6. "Arabidopsis PPP family of serine/threonine phosphatases."
    Farkas I., Dombradi V., Miskei M., Szabados L., Koncz C.
    Trends Plant Sci. 12:169-176(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENE FAMILY, NOMENCLATURE.

Entry informationi

Entry nameiPP11_ARATH
AccessioniPrimary (citable) accession number: P30366
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: July 22, 2015
This is version 129 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.