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P30366

- PP11_ARATH

UniProt

P30366 - PP11_ARATH

Protein

Serine/threonine-protein phosphatase PP1 isozyme 1

Gene

TOPP1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 122 (01 Oct 2014)
      Sequence version 1 (01 Apr 1993)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    [a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

    Cofactori

    Binds 2 manganese ions per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi77 – 771Manganese 1By similarity
    Metal bindingi79 – 791Manganese 1By similarity
    Metal bindingi105 – 1051Manganese 1By similarity
    Metal bindingi105 – 1051Manganese 2By similarity
    Metal bindingi137 – 1371Manganese 2By similarity
    Active sitei138 – 1381Proton donorBy similarity
    Metal bindingi186 – 1861Manganese 2By similarity
    Metal bindingi260 – 2601Manganese 2By similarity

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. protein serine/threonine phosphatase activity Source: TAIR

    GO - Biological processi

    1. protein dephosphorylation Source: TAIR

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Keywords - Ligandi

    Manganese, Metal-binding

    Enzyme and pathway databases

    BioCyciARA:AT2G29400-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Serine/threonine-protein phosphatase PP1 isozyme 1 (EC:3.1.3.16)
    Gene namesi
    Name:TOPP1
    Synonyms:PP1
    Ordered Locus Names:At2g29400
    ORF Names:F16P2.22
    OrganismiArabidopsis thaliana (Mouse-ear cress)
    Taxonomic identifieri3702 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
    ProteomesiUP000006548: Chromosome 2

    Organism-specific databases

    TAIRiAT2G29400.

    Subcellular locationi

    GO - Cellular componenti

    1. protein phosphatase type 1 complex Source: TAIR

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 318317Serine/threonine-protein phosphatase PP1 isozyme 1PRO_0000058797Add
    BLAST

    Proteomic databases

    PaxDbiP30366.
    PRIDEiP30366.

    Expressioni

    Gene expression databases

    GenevestigatoriP30366.

    Interactioni

    Protein-protein interaction databases

    IntActiP30366. 1 interaction.
    STRINGi3702.AT2G29400.1-P.

    Structurei

    3D structure databases

    ProteinModelPortaliP30366.
    SMRiP30366. Positions 20-310.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the PPP phosphatase family. PP-1 subfamily.Curated

    Phylogenomic databases

    eggNOGiCOG0639.
    HOGENOMiHOG000172697.
    InParanoidiP30366.
    KOiK06269.
    OMAiMGDVMNI.
    PhylomeDBiP30366.

    Family and domain databases

    Gene3Di3.60.21.10. 1 hit.
    InterProiIPR004843. Calcineurin-like_PHP_apaH.
    IPR029052. Metallo-depent_PP-like.
    IPR006186. Ser/Thr-sp_prot-phosphatase.
    [Graphical view]
    PfamiPF00149. Metallophos. 1 hit.
    [Graphical view]
    PRINTSiPR00114. STPHPHTASE.
    SMARTiSM00156. PP2Ac. 1 hit.
    [Graphical view]
    SUPFAMiSSF56300. SSF56300. 1 hit.
    PROSITEiPS00125. SER_THR_PHOSPHATASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P30366-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAEKPAQEQE QKRAMEPAVL DDIIRRLVEF RNTRPGSGKQ VHLSEGEIRQ    50
    LCAVSKEIFL QQPNLLELEA PIKICGDIHG QYSDLLRLFE YGGFPPEANY 100
    LFLGDYVDRG KQSLETICLL LAYKIKYPEN FFLLRGNHES ASINRIYGFY 150
    DECKRRFNVR LWKIFTDCFN CLPVAALIDD RILCMHGGIS PELKSLDQIR 200
    NIARPMDIPE SGLVCDLLWS DPSGDVGWGM NDRGVSYTFG ADKVAEFLEK 250
    HDMDLICRAH QVVEDGYEFF AERQLVTVFS APNYCGEFDN AGAMMSIDES 300
    LMCSFQILKP SEKKSPFL 318
    Length:318
    Mass (Da):36,279
    Last modified:April 1, 1993 - v1
    Checksum:iDAAA11674B148294
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X64328 mRNA. Translation: CAA45611.1.
    M93408 mRNA. Translation: AAA32723.1.
    AC004561 Genomic DNA. Translation: AAC95198.1.
    CP002685 Genomic DNA. Translation: AEC08250.1.
    AY080871 mRNA. Translation: AAL87342.1.
    AY142593 mRNA. Translation: AAN13162.1.
    PIRiS20882.
    RefSeqiNP_180501.1. NM_128494.4.
    UniGeneiAt.282.

    Genome annotation databases

    EnsemblPlantsiAT2G29400.1; AT2G29400.1; AT2G29400.
    GeneIDi817489.
    KEGGiath:AT2G29400.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X64328 mRNA. Translation: CAA45611.1 .
    M93408 mRNA. Translation: AAA32723.1 .
    AC004561 Genomic DNA. Translation: AAC95198.1 .
    CP002685 Genomic DNA. Translation: AEC08250.1 .
    AY080871 mRNA. Translation: AAL87342.1 .
    AY142593 mRNA. Translation: AAN13162.1 .
    PIRi S20882.
    RefSeqi NP_180501.1. NM_128494.4.
    UniGenei At.282.

    3D structure databases

    ProteinModelPortali P30366.
    SMRi P30366. Positions 20-310.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P30366. 1 interaction.
    STRINGi 3702.AT2G29400.1-P.

    Proteomic databases

    PaxDbi P30366.
    PRIDEi P30366.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi AT2G29400.1 ; AT2G29400.1 ; AT2G29400 .
    GeneIDi 817489.
    KEGGi ath:AT2G29400.

    Organism-specific databases

    TAIRi AT2G29400.

    Phylogenomic databases

    eggNOGi COG0639.
    HOGENOMi HOG000172697.
    InParanoidi P30366.
    KOi K06269.
    OMAi MGDVMNI.
    PhylomeDBi P30366.

    Enzyme and pathway databases

    BioCyci ARA:AT2G29400-MONOMER.

    Gene expression databases

    Genevestigatori P30366.

    Family and domain databases

    Gene3Di 3.60.21.10. 1 hit.
    InterProi IPR004843. Calcineurin-like_PHP_apaH.
    IPR029052. Metallo-depent_PP-like.
    IPR006186. Ser/Thr-sp_prot-phosphatase.
    [Graphical view ]
    Pfami PF00149. Metallophos. 1 hit.
    [Graphical view ]
    PRINTSi PR00114. STPHPHTASE.
    SMARTi SM00156. PP2Ac. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56300. SSF56300. 1 hit.
    PROSITEi PS00125. SER_THR_PHOSPHATASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complementation of the cs dis2-11 cell cycle mutant of Schizosaccharomyces pombe by a protein phosphatase from Arabidopsis thaliana."
      Nitschke K., Fleig U., Schell J., Palme K.
      EMBO J. 11:1327-1333(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: cv. Columbia.
    2. "Expression of multiple type 1 phosphoprotein phosphatases in Arabidopsis thaliana."
      Smith R.D., Walker J.C.
      Plant Mol. Biol. 21:307-316(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Columbia.
    4. The Arabidopsis Information Resource (TAIR)
      Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: GENOME REANNOTATION.
      Strain: cv. Columbia.
    5. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
      Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
      , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
      Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: cv. Columbia.
    6. "Arabidopsis PPP family of serine/threonine phosphatases."
      Farkas I., Dombradi V., Miskei M., Szabados L., Koncz C.
      Trends Plant Sci. 12:169-176(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: GENE FAMILY, NOMENCLATURE.

    Entry informationi

    Entry nameiPP11_ARATH
    AccessioniPrimary (citable) accession number: P30366
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 1, 1993
    Last sequence update: April 1, 1993
    Last modified: October 1, 2014
    This is version 122 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Arabidopsis thaliana
      Arabidopsis thaliana: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3