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P30366 (PP11_ARATH) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 121. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Serine/threonine-protein phosphatase PP1 isozyme 1

EC=3.1.3.16
Gene names
Name:TOPP1
Synonyms:PP1
Ordered Locus Names:At2g29400
ORF Names:F16P2.22
OrganismArabidopsis thaliana (Mouse-ear cress) [Reference proteome]
Taxonomic identifier3702 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis

Protein attributes

Sequence length318 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactor

Binds 2 manganese ions per subunit By similarity.

Sequence similarities

Belongs to the PPP phosphatase family. PP-1 subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 318317Serine/threonine-protein phosphatase PP1 isozyme 1
PRO_0000058797

Sites

Active site1381Proton donor By similarity
Metal binding771Manganese 1 By similarity
Metal binding791Manganese 1 By similarity
Metal binding1051Manganese 1 By similarity
Metal binding1051Manganese 2 By similarity
Metal binding1371Manganese 2 By similarity
Metal binding1861Manganese 2 By similarity
Metal binding2601Manganese 2 By similarity

Sequences

Sequence LengthMass (Da)Tools
P30366 [UniParc].

Last modified April 1, 1993. Version 1.
Checksum: DAAA11674B148294

FASTA31836,279
        10         20         30         40         50         60 
MAEKPAQEQE QKRAMEPAVL DDIIRRLVEF RNTRPGSGKQ VHLSEGEIRQ LCAVSKEIFL 

        70         80         90        100        110        120 
QQPNLLELEA PIKICGDIHG QYSDLLRLFE YGGFPPEANY LFLGDYVDRG KQSLETICLL 

       130        140        150        160        170        180 
LAYKIKYPEN FFLLRGNHES ASINRIYGFY DECKRRFNVR LWKIFTDCFN CLPVAALIDD 

       190        200        210        220        230        240 
RILCMHGGIS PELKSLDQIR NIARPMDIPE SGLVCDLLWS DPSGDVGWGM NDRGVSYTFG 

       250        260        270        280        290        300 
ADKVAEFLEK HDMDLICRAH QVVEDGYEFF AERQLVTVFS APNYCGEFDN AGAMMSIDES 

       310 
LMCSFQILKP SEKKSPFL 

« Hide

References

« Hide 'large scale' references
[1]"Complementation of the cs dis2-11 cell cycle mutant of Schizosaccharomyces pombe by a protein phosphatase from Arabidopsis thaliana."
Nitschke K., Fleig U., Schell J., Palme K.
EMBO J. 11:1327-1333(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: cv. Columbia.
[2]"Expression of multiple type 1 phosphoprotein phosphatases in Arabidopsis thaliana."
Smith R.D., Walker J.C.
Plant Mol. Biol. 21:307-316(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana."
Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D., Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V., Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S., Cronin L.A. expand/collapse author list , Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J., Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M., Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O., Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.
Nature 402:761-768(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: cv. Columbia.
[4]The Arabidopsis Information Resource (TAIR)
Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: cv. Columbia.
[5]"Empirical analysis of transcriptional activity in the Arabidopsis genome."
Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G. expand/collapse author list , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: cv. Columbia.
[6]"Arabidopsis PPP family of serine/threonine phosphatases."
Farkas I., Dombradi V., Miskei M., Szabados L., Koncz C.
Trends Plant Sci. 12:169-176(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: GENE FAMILY, NOMENCLATURE.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X64328 mRNA. Translation: CAA45611.1.
M93408 mRNA. Translation: AAA32723.1.
AC004561 Genomic DNA. Translation: AAC95198.1.
CP002685 Genomic DNA. Translation: AEC08250.1.
AY080871 mRNA. Translation: AAL87342.1.
AY142593 mRNA. Translation: AAN13162.1.
PIRS20882.
RefSeqNP_180501.1. NM_128494.4.
UniGeneAt.282.

3D structure databases

ProteinModelPortalP30366.
SMRP30366. Positions 20-310.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActP30366. 1 interaction.
STRING3702.AT2G29400.1-P.

Proteomic databases

PaxDbP30366.
PRIDEP30366.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsAT2G29400.1; AT2G29400.1; AT2G29400.
GeneID817489.
KEGGath:AT2G29400.

Organism-specific databases

TAIRAT2G29400.

Phylogenomic databases

eggNOGCOG0639.
HOGENOMHOG000172697.
InParanoidP30366.
KOK06269.
OMAMGDVMNI.
PhylomeDBP30366.

Enzyme and pathway databases

BioCycARA:AT2G29400-MONOMER.

Gene expression databases

GenevestigatorP30366.

Family and domain databases

Gene3D3.60.21.10. 1 hit.
InterProIPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
IPR006186. Ser/Thr-sp_prot-phosphatase.
[Graphical view]
PfamPF00149. Metallophos. 1 hit.
[Graphical view]
PRINTSPR00114. STPHPHTASE.
SMARTSM00156. PP2Ac. 1 hit.
[Graphical view]
SUPFAMSSF56300. SSF56300. 1 hit.
PROSITEPS00125. SER_THR_PHOSPHATASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePP11_ARATH
AccessionPrimary (citable) accession number: P30366
Entry history
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: June 11, 2014
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Arabidopsis thaliana

Arabidopsis thaliana: entries and gene names