Reviewed, UniProtKB/Swiss-Prot P30350 (ADH1_ANAPL)

Names and origin

Protein names

Recommended name:
    Alcohol dehydrogenase 1
    EC=1.1.1.1

Gene names

Name:

ADH1

Organism

Anas platyrhynchos (Domestic duck) (Anas boschas)

Taxonomic identifier

8839 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Anseriformes › Anatidae › Anas

Protein attributes

Sequence length	185 AA.
Sequence status	Fragment.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	An alcohol + NAD+ = an aldehyde or ketone + NADH.
Cofactor	Binds 2 zinc ions per subunit By similarity.
Subunit structure	Homodimer.
Subcellular location	Cytoplasm.
Sequence similarities	Belongs to the zinc-containing alcohol dehydrogenase family. Class-I subfamily.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	Metal-binding NAD Zinc
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	alcohol dehydrogenase activity Inferred from electronic annotation. Source: EC zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	‹1 – 185	›185	Alcohol dehydrogenase 1		PRO_0000160670
Regions
	Nucleotide binding	10 – 15	6	NAD By similarity
	Nucleotide binding	103 – 105	3	NAD By similarity
Sites
	Binding site	34	1	NAD By similarity
	Binding site	39	1	NAD By similarity
	Binding site	180	1	NAD By similarity
Experimental info
	Non-terminal residue	1	1

Sequences

	Sequence		Length	Mass (Da)
	P30350-1 [UniParc]. Last modified April 1, 1993. Version 1. Checksum: BDA5DF3534C6192D	FASTA	185	19,816
	10 20 30 40 50 60 ARGSTCAVFG LGGVGLSVIM GCKAAGASRI IAVDINSDKF AKAKELGATD CINPKDHKEP 70 80 90 100 110 120 IHKVLIGMTG YGVDYSFEVI GRIETMVAAL ASCHYNYGVS VIVGVPPAAQ NITFDPMLLF 130 140 150 160 170 180 SGRTWKGSVF GGWKSKDSVP KLVADYMKKK FVLDPLITHT LPFSKINEGF DLLRAGKSIR SVLTF

References

[1]	"Estrogen induction of alcohol dehydrogenase in the uropygial gland of mallard ducks." Hiremath L.S., Kessler P.M., Sasaki G.C., Kolattukudy P.E. Eur. J. Biochem. 203:449-457(1992) [PubMed: 1370936] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Uropygial gland.

Cross-references

Sequence databases
EMBLGenBankDDBJ	X63948 mRNA. Translation: CAA45373.1.
PIR	S20593.
3D structure databases
HSSP	HSSP built from PDB template 1EE2 based on UniProtKB P00328.
SMR	P30350. Positions 2-185.
ModBase	Search...
Phylogenomic databases
HOVERGEN	P30350.
Enzyme and pathway databases
BRENDA	1.1.1.1. 3217.
Family and domain databases
InterPro	IPR002085. ADH_SF_Zn. IPR013149. ADH_Zn-bd. IPR002328. ADH_Zn_CS. IPR016040. NAD(P)-bd_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
PANTHER	PTHR11695. ADH_Sf_Zn. 1 hit.
Pfam	PF00107. ADH_zinc_N. 1 hit. [Graphical view]
PROSITE	PS00059. ADH_ZINC. Partial match. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ADH1_ANAPL

Accession

Primary (citable) accession number: P30350

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 1, 1993
Last sequence update:	April 1, 1993
Last modified:	June 16, 2009
This is version 52 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)