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Protein

C-X-C motif chemokine 2

Gene

Cxcl2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Chemotactic for human polymorphonuclear leukocytes but does not induce chemokinesis or an oxidative burst. Contributes to neutrophil activation during inflammation.

GO - Molecular functioni

  • chemokine activity Source: RGD
  • CXCR chemokine receptor binding Source: GO_Central

GO - Biological processi

  • cellular response to interleukin-1 Source: RGD
  • cellular response to lipopolysaccharide Source: RGD
  • chemokine-mediated signaling pathway Source: GO_Central
  • G-protein coupled receptor signaling pathway Source: GO_Central
  • immune response Source: GO_Central
  • inflammatory response Source: GO_Central
  • leukocyte chemotaxis Source: RGD
  • neuron death Source: RGD
  • neutrophil chemotaxis Source: RGD
  • positive regulation of cytosolic calcium ion concentration Source: RGD
  • positive regulation of neutrophil chemotaxis Source: GO_Central
  • regulation of cell proliferation Source: GO_Central
  • response to amphetamine Source: RGD
  • response to estradiol Source: RGD
  • response to gamma radiation Source: RGD
  • response to glucocorticoid Source: RGD
  • response to heat Source: RGD
  • wound healing Source: RGD

Keywordsi

Molecular functionCytokine
Biological processChemotaxis, Inflammatory response

Enzyme and pathway databases

ReactomeiR-RNO-380108. Chemokine receptors bind chemokines.
R-RNO-418594. G alpha (i) signalling events.
R-RNO-6798695. Neutrophil degranulation.

Names & Taxonomyi

Protein namesi
Recommended name:
C-X-C motif chemokine 2
Alternative name(s):
Cytokine-induced neutrophil chemoattractant 3
Short name:
CINC-3
Macrophage inflammatory protein 2
Short name:
MIP2
Gene namesi
Name:Cxcl2
Synonyms:Cinc3, Mip-2, Mip2, Scyb2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 14

Organism-specific databases

RGDi70069. Cxcl2.

Subcellular locationi

GO - Cellular componenti

  • cell Source: GOC
  • extracellular space Source: RGD

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 313 PublicationsAdd BLAST31
ChainiPRO_000000506232 – 100C-X-C motif chemokine 2Add BLAST69

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi36 ↔ 62By similarity
Disulfide bondi38 ↔ 78By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP30348.
PRIDEiP30348.

Expressioni

Tissue specificityi

At least expressed in the lung and trachea.

Inductioni

By lipopolysaccharide (LPS) and inflammation; in lung.

Gene expression databases

BgeeiENSRNOG00000002792.
GenevisibleiP30348. RN.

Interactioni

Subunit structurei

Homotetramer.

GO - Molecular functioni

  • chemokine activity Source: RGD
  • CXCR chemokine receptor binding Source: GO_Central

Protein-protein interaction databases

BioGridi250284. 1 interactor.
STRINGi10116.ENSRNOP00000003745.

Structurei

3D structure databases

ProteinModelPortaliP30348.
SMRiP30348.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J3WE. Eukaryota.
ENOG410ZT1C. LUCA.
GeneTreeiENSGT00530000062901.
HOGENOMiHOG000220915.
HOVERGENiHBG107789.
InParanoidiP30348.
KOiK05505.
OMAiNGKKACL.
OrthoDBiEOG091G14TE.
PhylomeDBiP30348.
TreeFamiTF333433.

Family and domain databases

CDDicd00273. Chemokine_CXC. 1 hit.
InterProiView protein in InterPro
IPR001089. Chemokine_CXC.
IPR018048. Chemokine_CXC_CS.
IPR001811. Chemokine_IL8-like_dom.
IPR033899. CXC_Chemokine_domain.
PANTHERiPTHR10179. PTHR10179. 1 hit.
PfamiView protein in Pfam
PF00048. IL8. 1 hit.
PRINTSiPR00437. SMALLCYTKCXC.
SMARTiView protein in SMART
SM00199. SCY. 1 hit.
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiView protein in PROSITE
PS00471. SMALL_CYTOKINES_CXC. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P30348-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPPTRQLLN AVLVLLLLLA TNHQGTGVVV ASELRCQCLT TLPRVDFKNI
60 70 80 90 100
QSLTVTPPGP HCAQTEVIAT LKDGHEVCLN PEAPLVQRIV QKILNKGKAN
Length:100
Mass (Da):10,783
Last modified:April 1, 1993 - v1
Checksum:i4299DFE68FF37A9B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X65647 mRNA. Translation: CAA46599.1.
S77604 mRNA. Translation: AAB33749.1.
U45965 mRNA. Translation: AAA92438.1.
AB060092 mRNA. Translation: BAB41105.1.
S45855 mRNA. No translation available.
PIRiS21467.
RefSeqiNP_446099.1. NM_053647.1.
UniGeneiRn.10230.

Genome annotation databases

EnsembliENSRNOT00000003745; ENSRNOP00000003745; ENSRNOG00000002792.
GeneIDi114105.
KEGGirno:114105.
UCSCiRGD:70069. rat.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiCXCL2_RAT
AccessioniPrimary (citable) accession number: P30348
Secondary accession number(s): Q5WA60
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: June 7, 2017
This is version 125 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families