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Protein

Probable cadmium-transporting ATPase

Gene

cadA

Organism
Bacillus pseudofirmus (strain OF4)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Couples the hydrolysis of ATP with the export of cadmium.By similarity

Catalytic activityi

ATP + H2O + Cd2+(In) = ADP + phosphate + Cd2+(Out).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi23CadmiumPROSITE-ProRule annotation1
Metal bindingi26CadmiumPROSITE-ProRule annotation1
Active sitei4124-aspartylphosphate intermediateCurated1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processCadmium resistance, Ion transport, Transport
LigandATP-binding, Cadmium, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBPSE398511:G1FZ3-4216-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Probable cadmium-transporting ATPaseCurated (EC:3.6.3.3By similarity)
Alternative name(s):
Cadmium-efflux ATPaseBy similarity
Gene namesi
Name:cadA
Ordered Locus Names:BpOF4_21834
Encoded oniPlasmid pBpOF4-021 Publication
OrganismiBacillus pseudofirmus (strain OF4)
Taxonomic identifieri398511 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000001544 Componenti: Plasmid pBpOF4-02

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei103 – 123HelicalSequence analysisAdd BLAST21
Transmembranei127 – 147HelicalSequence analysisAdd BLAST21
Transmembranei168 – 188HelicalSequence analysisAdd BLAST21
Transmembranei329 – 349HelicalSequence analysisAdd BLAST21
Transmembranei361 – 381HelicalSequence analysisAdd BLAST21
Transmembranei671 – 690HelicalSequence analysisAdd BLAST20
Transmembranei694 – 716HelicalSequence analysisAdd BLAST23

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000462451 – 723Probable cadmium-transporting ATPaseAdd BLAST723

Keywords - PTMi

Phosphoprotein

Structurei

3D structure databases

ProteinModelPortaliP30336
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini13 – 76HMAPROSITE-ProRule annotationAdd BLAST64

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000250399
KOiK01534
OMAiHEHSHCE
OrthoDBiPOG091H00YH

Family and domain databases

CDDicd00371 HMA, 1 hit
Gene3Di3.40.1110.10, 1 hit
3.40.50.1000, 2 hits
InterProiView protein in InterPro
IPR023299 ATPase_P-typ_cyto_dom_N
IPR018303 ATPase_P-typ_P_site
IPR023298 ATPase_P-typ_TM_dom_sf
IPR008250 ATPase_P-typ_transduc_dom_A_sf
IPR036412 HAD-like_sf
IPR023214 HAD_sf
IPR017969 Heavy-metal-associated_CS
IPR006121 HMA_dom
IPR036163 HMA_dom_sf
IPR027256 P-typ_ATPase_IB
IPR001757 P_typ_ATPase
PfamiView protein in Pfam
PF00403 HMA, 1 hit
PRINTSiPR00941 CDATPASE
SUPFAMiSSF55008 SSF55008, 1 hit
SSF56784 SSF56784, 2 hits
SSF81653 SSF81653, 1 hit
SSF81665 SSF81665, 3 hits
TIGRFAMsiTIGR01525 ATPase-IB_hvy, 1 hit
TIGR01494 ATPase_P-type, 1 hit
PROSITEiView protein in PROSITE
PS00154 ATPASE_E1_E2, 1 hit
PS01047 HMA_1, 1 hit
PS50846 HMA_2, 1 hit

Sequencei

Sequence statusi: Complete.

P30336-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDQKAITSE QEMKAYRVQG FTCANCAGKF EKNVKQLSGV EDAKVNFGAS
60 70 80 90 100
KIAVYGNATI EELEKAGAFE NLKVTPEKSA RQASQEVKED TKEDKVPFYK
110 120 130 140 150
KHSTLLYASL LIAFGYLSSY VNGEENIVTT LLFLASMFIG GLSLFKVGLQ
160 170 180 190 200
NLLRFEFDMK TLMTVAVIGG AIIGEWAEVA IVVILFAISE ALERFSMDRA
210 220 230 240 250
RQSIRSLMDI APKEALVKRN GQEIMIHVDD IAVGDIMIVK PGQKIAMDGV
260 270 280 290 300
VVSGYSAVNQ AAITGESVPV EKTVDNEVFA GTLNEEGLLE VEITKLVEDT
310 320 330 340 350
TISKIIHLVE EAQGERAPSQ AFVDKFAKYY TPIIMIIAAL VAIVPPLFFD
360 370 380 390 400
GSWETWIYQG LAVLVVGCPC ALVISTPISI VSAIGNAAKK GVLVKGGVYL
410 420 430 440 450
EEMGALKAIA FDKTGTLTKG VPAVTDYNVL NKQINEKELL SIITALEYRS
460 470 480 490 500
QHPLASAIMK KAEEENITYS DVQVEDFSSI TGKGIKGIVN GTTYYIGSPK
510 520 530 540 550
LFKELLTNDF DKDLEQNVTT LQNQGKTAMI IGTEKEILAV IAVADEVRES
560 570 580 590 600
SKEILQKLHQ LGIKKTIMLT GDNKGTANAI GGQVGVSDIE AELMPQDKLD
610 620 630 640 650
FIKQLRSEYG NVAMVGDGVN DAPALAASTV GIAMGGAGTD TALETADVAL
660 670 680 690 700
MGDDLRKLPF TVKLSRKTLN IIKANITFAI AIKFIALLLV IPGWLTLWIA
710 720
ILSDMGATLL VALNGLRLMR VKE
Length:723
Mass (Da):78,204
Last modified:June 15, 2010 - v2
Checksum:i975D709B3754D5EF
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti113A → T in AAA22858 (PubMed:1321115).Curated1
Sequence conflicti261A → T in AAA22858 (PubMed:1321115).Curated1
Sequence conflicti339A → T in AAA22858 (PubMed:1321115).Curated1
Sequence conflicti660F → S in AAA22858 (PubMed:1321115).Curated1
Sequence conflicti687L → S in AAA22858 (PubMed:1321115).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M90750 Genomic DNA Translation: AAA22858.1
CP001880 Genomic DNA Translation: ADC52362.1
PIRiD42707
RefSeqiWP_012961265.1, NC_013793.1

Genome annotation databases

EnsemblBacteriaiADC52362; ADC52362; BpOF4_21834
KEGGibpf:BpOF4_21834

Similar proteinsi

Entry informationi

Entry nameiCADA_BACPE
AccessioniPrimary (citable) accession number: P30336
Secondary accession number(s): D3G1Y6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: June 15, 2010
Last modified: March 28, 2018
This is version 133 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Plasmid, Reference proteome
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Main funding by: National Institutes of Health