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Protein

Metallothionein

Gene

smtA

Organism
Synechococcus elongatus (strain PCC 7942) (Anacystis nidulans R2)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in essential metal ion homeostasis (especially zinc homeostasis) and resistance to certain non-essential metal ions. Metallothioneins have a high content of cysteine residues that bind various heavy metals.

GO - Molecular functioni

Keywordsi

LigandCadmium, Copper, Mercury, Metal-binding, Metal-thiolate cluster, Zinc

Enzyme and pathway databases

BioCyciSYNEL:SYNPCC7942_1290-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Metallothionein
Short name:
MT
Gene namesi
Name:smtA
Ordered Locus Names:Synpcc7942_1290
OrganismiSynechococcus elongatus (strain PCC 7942) (Anacystis nidulans R2)
Taxonomic identifieri1140 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaSynechococcalesSynechococcaceaeSynechococcus
Proteomesi
  • UP000002717 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved
ChainiPRO_00001973712 – 56MetallothioneinAdd BLAST55

Proteomic databases

PRIDEiP30331.

Expressioni

Inductioni

Upon exposure to a range of metals, particularly cadmium, zinc, copper and mercury.

Interactioni

Protein-protein interaction databases

STRINGi1140.Synpcc7942_1290.

Structurei

Secondary structure

156
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni20 – 22Combined sources3
Beta strandi23 – 28Combined sources6
Beta strandi30 – 33Combined sources4
Helixi34 – 38Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1JJDNMR-A2-56[»]
ProteinModelPortaliP30331.
SMRiP30331.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP30331.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4106DI1. Bacteria.
ENOG410Y0GM. LUCA.
HOGENOMiHOG000032800.
OrthoDBiPOG091H0SC6.

Family and domain databases

InterProiView protein in InterPro
IPR017854. Metalthion_dom.
IPR000518. Metalthion_fam14_prok.
PfamiView protein in Pfam
PF02069. Metallothio_Pro. 1 hit.
PRINTSiPR00859. MTPROKARYOTE.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD019076. Metallthion_Pro. 1 hit.
SUPFAMiSSF57868. SSF57868. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P30331-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSTTLVKCA CEPCLCNVDP SKAIDRNGLY YCSEACADGH TGGSKGCGHT

GCNCHG
Length:56
Mass (Da):5,741
Last modified:January 23, 2007 - v2
Checksum:iE76846D6086F2524
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X64585 Genomic DNA. Translation: CAA45873.1.
CP000100 Genomic DNA. Translation: ABB57320.1.
PIRiS31198.
RefSeqiWP_011377964.1. NC_007604.1.

Genome annotation databases

EnsemblBacteriaiABB57320; ABB57320; Synpcc7942_1290.
KEGGisyf:Synpcc7942_1290.

Similar proteinsi

Entry informationi

Entry nameiMT_SYNE7
AccessioniPrimary (citable) accession number: P30331
Secondary accession number(s): Q31NP9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: January 23, 2007
Last modified: July 5, 2017
This is version 101 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Metallothioneins
    Classification of metallothioneins and list of entries
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families