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P30311

- MPIP3_XENLA

UniProt

P30311 - MPIP3_XENLA

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Protein
M-phase inducer phosphatase 3
Gene
cdc25-3
Organism
Xenopus laevis (African clawed frog)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

This protein functions as a dosage-dependent inducer in mitotic control. It is a tyrosine protein phosphatase required for progression of the cell cycle. It may directly dephosphorylate p34(cdc2) and activate the p34(cdc2) kinase activity.

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei476 – 4761 By similarity

GO - Molecular functioni

  1. protein tyrosine phosphatase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

  1. mitotic nuclear division Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Biological processi

Cell cycle, Cell division, Mitosis

Names & Taxonomyi

Protein namesi
Recommended name:
M-phase inducer phosphatase 3 (EC:3.1.3.48)
Gene namesi
Name:cdc25-3
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-6252614. cdc25c.

Subcellular locationi

GO - Cellular componenti

  1. intracellular Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 572572M-phase inducer phosphatase 3
PRO_0000198654Add
BLAST

Interactioni

Protein-protein interaction databases

BioGridi99076. 2 interactions.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi68 – 703

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1I8GNMR-A63-72[»]
ProteinModelPortaliP30311.
SMRiP30311. Positions 381-541.

Miscellaneous databases

EvolutionaryTraceiP30311.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini420 – 527108Rhodanese
Add
BLAST

Sequence similaritiesi

Belongs to the MPI phosphatase family.
Contains 1 rhodanese domain.

Phylogenomic databases

HOVERGENiHBG052501.
KOiK05867.

Family and domain databases

Gene3Di3.40.250.10. 1 hit.
InterProiIPR000751. MPI_Phosphatase.
IPR001763. Rhodanese-like_dom.
[Graphical view]
PfamiPF06617. M-inducer_phosp. 1 hit.
PF00581. Rhodanese. 1 hit.
[Graphical view]
PRINTSiPR00716. MPIPHPHTASE.
SMARTiSM00450. RHOD. 1 hit.
[Graphical view]
SUPFAMiSSF52821. SSF52821. 1 hit.
PROSITEiPS50206. RHODANESE_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P30311-1 [UniParc]FASTAAdd to Basket

« Hide

MIKERVTPPF QASGGSGVVM AESHIISSEA PPKSNPGLNI RTNCRMILNL    50
LREKDCSVTF SPEQPLTPVT DLAVGFSNLS TFSGETPKRC LDLSNLGDET 100
APLPTESPDR MSSGKLESPK TQFVQFDGLF TPDLAWKAKK CPKRNMNSVL 150
PHLLCSTPSF KKASGGQRSL SNKENEGELF KNPNCKPVAL LLPQEVVDSQ 200
LSPTPENKVD ISLDEDCEMN ILGSPISADP PCLDGAHDDI KMQNLDGFAD 250
FFSVDEEEME NPPGAVGNLS CSMAILLSGP LLNQDVEISN VNNISLNRSR 300
LYRSPSMPEK LDRPMLKRPV RPLNSETPVR VKRRRSTSSP LQPEEENCQP 350
QRRGTSLKKT LSLCDVDISS VLDEDCGHRQ LIGDFSKVYA LPTVTGRHQD 400
LRYITGETLA ALMHGDFNSL VEKFFIIDCR YPYEYDGGHI KSAFNLHRQD 450
EVTDYFLQQP LTPLMAQKRL IIIFHCEFSS ERGPKMCRSL REEDRASNDY 500
PSLYYPELYL LKGGYKDFFP EYKELCEPQS YCPMHHQDFR EDLLKFRTKC 550
KTSVGDRKRR EPEFRLTGQR LG 572
Length:572
Mass (Da):64,413
Last modified:April 1, 1993 - v1
Checksum:iB268EA4BAA3971AC
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M94264 mRNA. Translation: AAA49675.1.
PIRiC42679.
RefSeqiNP_001081256.1. NM_001087787.1.
UniGeneiXl.85437.

Genome annotation databases

GeneIDi397737.
KEGGixla:397737.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M94264 mRNA. Translation: AAA49675.1 .
PIRi C42679.
RefSeqi NP_001081256.1. NM_001087787.1.
UniGenei Xl.85437.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1I8G NMR - A 63-72 [» ]
ProteinModelPortali P30311.
SMRi P30311. Positions 381-541.
ModBasei Search...

Protein-protein interaction databases

BioGridi 99076. 2 interactions.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 397737.
KEGGi xla:397737.

Organism-specific databases

CTDi 397737.
Xenbasei XB-GENE-6252614. cdc25c.

Phylogenomic databases

HOVERGENi HBG052501.
KOi K05867.

Miscellaneous databases

EvolutionaryTracei P30311.

Family and domain databases

Gene3Di 3.40.250.10. 1 hit.
InterProi IPR000751. MPI_Phosphatase.
IPR001763. Rhodanese-like_dom.
[Graphical view ]
Pfami PF06617. M-inducer_phosp. 1 hit.
PF00581. Rhodanese. 1 hit.
[Graphical view ]
PRINTSi PR00716. MPIPHPHTASE.
SMARTi SM00450. RHOD. 1 hit.
[Graphical view ]
SUPFAMi SSF52821. SSF52821. 1 hit.
PROSITEi PS50206. RHODANESE_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Regulation of the cdc25 protein during the cell cycle in Xenopus extracts."
    Kumagai A., Dunphy W.G.
    Cell 70:139-151(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiMPIP3_XENLA
AccessioniPrimary (citable) accession number: P30311
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: September 3, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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