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P30311 (MPIP3_XENLA) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 81. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
M-phase inducer phosphatase 3

EC=3.1.3.48
Gene names
Name:cdc25-3
OrganismXenopus laevis (African clawed frog)
Taxonomic identifier8355 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Protein attributes

Sequence length572 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

This protein functions as a dosage-dependent inducer in mitotic control. It is a tyrosine protein phosphatase required for progression of the cell cycle. It may directly dephosphorylate p34(cdc2) and activate the p34(cdc2) kinase activity.

Catalytic activity

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

Sequence similarities

Belongs to the MPI phosphatase family.

Contains 1 rhodanese domain.

Ontologies

Keywords
   Biological processCell cycle
Cell division
Mitosis
   Molecular functionHydrolase
Protein phosphatase
   Technical term3D-structure
Gene Ontology (GO)
   Biological_processmitotic nuclear division

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentintracellular

Inferred from electronic annotation. Source: InterPro

   Molecular_functionprotein tyrosine phosphatase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 572572M-phase inducer phosphatase 3
PRO_0000198654

Regions

Domain420 – 527108Rhodanese

Sites

Active site4761 By similarity

Secondary structure

... 572
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P30311 [UniParc].

Last modified April 1, 1993. Version 1.
Checksum: B268EA4BAA3971AC

FASTA57264,413
        10         20         30         40         50         60 
MIKERVTPPF QASGGSGVVM AESHIISSEA PPKSNPGLNI RTNCRMILNL LREKDCSVTF 

        70         80         90        100        110        120 
SPEQPLTPVT DLAVGFSNLS TFSGETPKRC LDLSNLGDET APLPTESPDR MSSGKLESPK 

       130        140        150        160        170        180 
TQFVQFDGLF TPDLAWKAKK CPKRNMNSVL PHLLCSTPSF KKASGGQRSL SNKENEGELF 

       190        200        210        220        230        240 
KNPNCKPVAL LLPQEVVDSQ LSPTPENKVD ISLDEDCEMN ILGSPISADP PCLDGAHDDI 

       250        260        270        280        290        300 
KMQNLDGFAD FFSVDEEEME NPPGAVGNLS CSMAILLSGP LLNQDVEISN VNNISLNRSR 

       310        320        330        340        350        360 
LYRSPSMPEK LDRPMLKRPV RPLNSETPVR VKRRRSTSSP LQPEEENCQP QRRGTSLKKT 

       370        380        390        400        410        420 
LSLCDVDISS VLDEDCGHRQ LIGDFSKVYA LPTVTGRHQD LRYITGETLA ALMHGDFNSL 

       430        440        450        460        470        480 
VEKFFIIDCR YPYEYDGGHI KSAFNLHRQD EVTDYFLQQP LTPLMAQKRL IIIFHCEFSS 

       490        500        510        520        530        540 
ERGPKMCRSL REEDRASNDY PSLYYPELYL LKGGYKDFFP EYKELCEPQS YCPMHHQDFR 

       550        560        570 
EDLLKFRTKC KTSVGDRKRR EPEFRLTGQR LG 

« Hide

References

[1]"Regulation of the cdc25 protein during the cell cycle in Xenopus extracts."
Kumagai A., Dunphy W.G.
Cell 70:139-151(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M94264 mRNA. Translation: AAA49675.1.
PIRC42679.
RefSeqNP_001081256.1. NM_001087787.1.
UniGeneXl.85437.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1I8GNMR-A63-72[»]
ProteinModelPortalP30311.
SMRP30311. Positions 381-541.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid99076. 2 interactions.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID397737.
KEGGxla:397737.

Organism-specific databases

CTD397737.
XenbaseXB-GENE-6252614. cdc25c.

Phylogenomic databases

HOVERGENHBG052501.
KOK05867.

Family and domain databases

Gene3D3.40.250.10. 1 hit.
InterProIPR000751. MPI_Phosphatase.
IPR001763. Rhodanese-like_dom.
[Graphical view]
PfamPF06617. M-inducer_phosp. 1 hit.
PF00581. Rhodanese. 1 hit.
[Graphical view]
PRINTSPR00716. MPIPHPHTASE.
SMARTSM00450. RHOD. 1 hit.
[Graphical view]
SUPFAMSSF52821. SSF52821. 1 hit.
PROSITEPS50206. RHODANESE_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceP30311.

Entry information

Entry nameMPIP3_XENLA
AccessionPrimary (citable) accession number: P30311
Entry history
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: April 16, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references