Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

M-phase inducer phosphatase 3

Gene

cdc25-3

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

This protein functions as a dosage-dependent inducer in mitotic control. It is a tyrosine protein phosphatase required for progression of the cell cycle. It may directly dephosphorylate p34(cdc2) and activate the p34(cdc2) kinase activity.

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei476By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protein phosphatase
Biological processCell cycle, Cell division, Mitosis

Names & Taxonomyi

Protein namesi
Recommended name:
M-phase inducer phosphatase 3 (EC:3.1.3.48)
Gene namesi
Name:cdc25-3
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-6252614. cdc25c.

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001986541 – 572M-phase inducer phosphatase 3Add BLAST572

Interactioni

Protein-protein interaction databases

BioGridi99076. 2 interactors.

Structurei

Secondary structure

1572
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi68 – 70Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1I8GNMR-A63-72[»]
ProteinModelPortaliP30311.
SMRiP30311.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP30311.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini420 – 527RhodanesePROSITE-ProRule annotationAdd BLAST108

Sequence similaritiesi

Belongs to the MPI phosphatase family.Curated

Phylogenomic databases

HOVERGENiHBG052501.
KOiK05867.

Family and domain databases

CDDicd01530. Cdc25. 1 hit.
Gene3Di3.40.250.10. 1 hit.
InterProiView protein in InterPro
IPR000751. MPI_Phosphatase.
IPR001763. Rhodanese-like_dom.
PfamiView protein in Pfam
PF06617. M-inducer_phosp. 1 hit.
PF00581. Rhodanese. 1 hit.
PRINTSiPR00716. MPIPHPHTASE.
SMARTiView protein in SMART
SM00450. RHOD. 1 hit.
SUPFAMiSSF52821. SSF52821. 1 hit.
PROSITEiView protein in PROSITE
PS50206. RHODANESE_3. 1 hit.

Sequencei

Sequence statusi: Complete.

P30311-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIKERVTPPF QASGGSGVVM AESHIISSEA PPKSNPGLNI RTNCRMILNL
60 70 80 90 100
LREKDCSVTF SPEQPLTPVT DLAVGFSNLS TFSGETPKRC LDLSNLGDET
110 120 130 140 150
APLPTESPDR MSSGKLESPK TQFVQFDGLF TPDLAWKAKK CPKRNMNSVL
160 170 180 190 200
PHLLCSTPSF KKASGGQRSL SNKENEGELF KNPNCKPVAL LLPQEVVDSQ
210 220 230 240 250
LSPTPENKVD ISLDEDCEMN ILGSPISADP PCLDGAHDDI KMQNLDGFAD
260 270 280 290 300
FFSVDEEEME NPPGAVGNLS CSMAILLSGP LLNQDVEISN VNNISLNRSR
310 320 330 340 350
LYRSPSMPEK LDRPMLKRPV RPLNSETPVR VKRRRSTSSP LQPEEENCQP
360 370 380 390 400
QRRGTSLKKT LSLCDVDISS VLDEDCGHRQ LIGDFSKVYA LPTVTGRHQD
410 420 430 440 450
LRYITGETLA ALMHGDFNSL VEKFFIIDCR YPYEYDGGHI KSAFNLHRQD
460 470 480 490 500
EVTDYFLQQP LTPLMAQKRL IIIFHCEFSS ERGPKMCRSL REEDRASNDY
510 520 530 540 550
PSLYYPELYL LKGGYKDFFP EYKELCEPQS YCPMHHQDFR EDLLKFRTKC
560 570
KTSVGDRKRR EPEFRLTGQR LG
Length:572
Mass (Da):64,413
Last modified:April 1, 1993 - v1
Checksum:iB268EA4BAA3971AC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M94264 mRNA. Translation: AAA49675.1.
PIRiC42679.
RefSeqiNP_001081256.1. NM_001087787.1.
UniGeneiXl.78641.
Xl.85437.

Genome annotation databases

GeneIDi397737.
KEGGixla:397737.

Similar proteinsi

Entry informationi

Entry nameiMPIP3_XENLA
AccessioniPrimary (citable) accession number: P30311
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: September 27, 2017
This is version 93 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families