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P30311

- MPIP3_XENLA

UniProt

P30311 - MPIP3_XENLA

Protein

M-phase inducer phosphatase 3

Gene

cdc25-3

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 83 (01 Oct 2014)
      Sequence version 1 (01 Apr 1993)
      Previous versions | rss
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    Functioni

    This protein functions as a dosage-dependent inducer in mitotic control. It is a tyrosine protein phosphatase required for progression of the cell cycle. It may directly dephosphorylate p34(cdc2) and activate the p34(cdc2) kinase activity.

    Catalytic activityi

    Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei476 – 4761By similarity

    GO - Molecular functioni

    1. protein tyrosine phosphatase activity Source: UniProtKB-EC

    GO - Biological processi

    1. mitotic nuclear division Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Keywords - Biological processi

    Cell cycle, Cell division, Mitosis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    M-phase inducer phosphatase 3 (EC:3.1.3.48)
    Gene namesi
    Name:cdc25-3
    OrganismiXenopus laevis (African clawed frog)
    Taxonomic identifieri8355 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

    Organism-specific databases

    XenbaseiXB-GENE-6252614. cdc25c.

    Subcellular locationi

    GO - Cellular componenti

    1. intracellular Source: InterPro

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 572572M-phase inducer phosphatase 3PRO_0000198654Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    BioGridi99076. 2 interactions.

    Structurei

    Secondary structure

    1
    572
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi68 – 703

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1I8GNMR-A63-72[»]
    ProteinModelPortaliP30311.
    SMRiP30311. Positions 381-541.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP30311.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini420 – 527108RhodanesePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the MPI phosphatase family.Curated
    Contains 1 rhodanese domain.PROSITE-ProRule annotation

    Phylogenomic databases

    HOVERGENiHBG052501.
    KOiK05867.

    Family and domain databases

    Gene3Di3.40.250.10. 1 hit.
    InterProiIPR000751. MPI_Phosphatase.
    IPR001763. Rhodanese-like_dom.
    [Graphical view]
    PfamiPF06617. M-inducer_phosp. 1 hit.
    PF00581. Rhodanese. 1 hit.
    [Graphical view]
    PRINTSiPR00716. MPIPHPHTASE.
    SMARTiSM00450. RHOD. 1 hit.
    [Graphical view]
    SUPFAMiSSF52821. SSF52821. 1 hit.
    PROSITEiPS50206. RHODANESE_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P30311-1 [UniParc]FASTAAdd to Basket

    « Hide

    MIKERVTPPF QASGGSGVVM AESHIISSEA PPKSNPGLNI RTNCRMILNL    50
    LREKDCSVTF SPEQPLTPVT DLAVGFSNLS TFSGETPKRC LDLSNLGDET 100
    APLPTESPDR MSSGKLESPK TQFVQFDGLF TPDLAWKAKK CPKRNMNSVL 150
    PHLLCSTPSF KKASGGQRSL SNKENEGELF KNPNCKPVAL LLPQEVVDSQ 200
    LSPTPENKVD ISLDEDCEMN ILGSPISADP PCLDGAHDDI KMQNLDGFAD 250
    FFSVDEEEME NPPGAVGNLS CSMAILLSGP LLNQDVEISN VNNISLNRSR 300
    LYRSPSMPEK LDRPMLKRPV RPLNSETPVR VKRRRSTSSP LQPEEENCQP 350
    QRRGTSLKKT LSLCDVDISS VLDEDCGHRQ LIGDFSKVYA LPTVTGRHQD 400
    LRYITGETLA ALMHGDFNSL VEKFFIIDCR YPYEYDGGHI KSAFNLHRQD 450
    EVTDYFLQQP LTPLMAQKRL IIIFHCEFSS ERGPKMCRSL REEDRASNDY 500
    PSLYYPELYL LKGGYKDFFP EYKELCEPQS YCPMHHQDFR EDLLKFRTKC 550
    KTSVGDRKRR EPEFRLTGQR LG 572
    Length:572
    Mass (Da):64,413
    Last modified:April 1, 1993 - v1
    Checksum:iB268EA4BAA3971AC
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M94264 mRNA. Translation: AAA49675.1.
    PIRiC42679.
    RefSeqiNP_001081256.1. NM_001087787.1.
    UniGeneiXl.85437.

    Genome annotation databases

    GeneIDi397737.
    KEGGixla:397737.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M94264 mRNA. Translation: AAA49675.1 .
    PIRi C42679.
    RefSeqi NP_001081256.1. NM_001087787.1.
    UniGenei Xl.85437.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1I8G NMR - A 63-72 [» ]
    ProteinModelPortali P30311.
    SMRi P30311. Positions 381-541.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 99076. 2 interactions.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 397737.
    KEGGi xla:397737.

    Organism-specific databases

    CTDi 397737.
    Xenbasei XB-GENE-6252614. cdc25c.

    Phylogenomic databases

    HOVERGENi HBG052501.
    KOi K05867.

    Miscellaneous databases

    EvolutionaryTracei P30311.

    Family and domain databases

    Gene3Di 3.40.250.10. 1 hit.
    InterProi IPR000751. MPI_Phosphatase.
    IPR001763. Rhodanese-like_dom.
    [Graphical view ]
    Pfami PF06617. M-inducer_phosp. 1 hit.
    PF00581. Rhodanese. 1 hit.
    [Graphical view ]
    PRINTSi PR00716. MPIPHPHTASE.
    SMARTi SM00450. RHOD. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52821. SSF52821. 1 hit.
    PROSITEi PS50206. RHODANESE_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Regulation of the cdc25 protein during the cell cycle in Xenopus extracts."
      Kumagai A., Dunphy W.G.
      Cell 70:139-151(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiMPIP3_XENLA
    AccessioniPrimary (citable) accession number: P30311
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 1, 1993
    Last sequence update: April 1, 1993
    Last modified: October 1, 2014
    This is version 83 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3