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Protein

M-phase inducer phosphatase 2

Gene

cdc25-2

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

This protein functions as a dosage-dependent inducer in mitotic control. It is a tyrosine protein phosphatase required for progression of the cell cycle. It may directly dephosphorylate p34(cdc2) and activate the p34(cdc2) kinase activity.

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei506By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protein phosphatase
Biological processCell cycle, Cell division, Mitosis

Names & Taxonomyi

Protein namesi
Recommended name:
M-phase inducer phosphatase 2 (EC:3.1.3.48)
Gene namesi
Name:cdc25-2
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001986531 – 599M-phase inducer phosphatase 2Add BLAST599

Proteomic databases

MaxQBiP30310.

Interactioni

Protein-protein interaction databases

MINTiMINT-92088.

Structurei

3D structure databases

ProteinModelPortaliP30310.
SMRiP30310.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini450 – 557RhodanesePROSITE-ProRule annotationAdd BLAST108

Sequence similaritiesi

Belongs to the MPI phosphatase family.Curated

Phylogenomic databases

HOVERGENiHBG052501.
KOiK05867.

Family and domain databases

CDDicd01530. Cdc25. 1 hit.
Gene3Di3.40.250.10. 1 hit.
InterProiView protein in InterPro
IPR000751. MPI_Phosphatase.
IPR001763. Rhodanese-like_dom.
IPR036873. Rhodanese-like_dom_sf.
PfamiView protein in Pfam
PF06617. M-inducer_phosp. 1 hit.
PF00581. Rhodanese. 1 hit.
PRINTSiPR00716. MPIPHPHTASE.
SMARTiView protein in SMART
SM00450. RHOD. 1 hit.
SUPFAMiSSF52821. SSF52821. 1 hit.
PROSITEiView protein in PROSITE
PS50206. RHODANESE_3. 1 hit.

Sequencei

Sequence statusi: Complete.

P30310-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYILLTLLTK STMESSCDNF EGLEHYYYTD AEPSSKCNKF QASGGSGVVM
60 70 80 90 100
AESHIMSSEA PPKSNPGLNI RTNCRMILNL LREKDCSVTF SPEQPLTPVT
110 120 130 140 150
DLAVGFSNLS TFSGETPKRC LDLSNLGDET APLPTESPDR MSSGKLESPK
160 170 180 190 200
TQFVQFGGLF TPDLAWKAKK CPKRNMNSVL PHLLCSTPSF KKASGGQRSL
210 220 230 240 250
SNKENEGELF KNPNCKPVAL LLPQEVVDSQ LSPTPENKVD ISLEEDCEMN
260 270 280 290 300
ILGSPISADP PCLDGAHDDI KMQNLDGFAD FFSVDEEEME NPPGAVGNLS
310 320 330 340 350
CSMAILLSGP LLNQDVEISN VNNISLNRSR LYRSPSMPEK LDRPMLKRPV
360 370 380 390 400
RPLDSETPVR VKRRRSTSSP LQPEEENCQP QRRGTSLKKT LSLCDVDIST
410 420 430 440 450
VLDEDCGHRQ LIGDFSKVYA LPTVTGRHQD LRYITGETLA ALMHGDFNSL
460 470 480 490 500
VEKFFIIDCR YPYEYDGGHI KSAFNLHRQE EVTDYFLQQP LTPLMVQKRL
510 520 530 540 550
IIIFHCEFSS ERGPKMCRFL REEDRASNDY PSLYYPELYL LKGGYKDFFP
560 570 580 590
EYKELCEPQS YCPMHHQDFR EDLLKFRTKC KTSVGDRKRR EQVARLMKL
Length:599
Mass (Da):67,646
Last modified:April 1, 1993 - v1
Checksum:iDB93EBD979367C4C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M94263 mRNA. Translation: AAA49673.1.
PIRiB42679. I51405.
RefSeqiNP_001165649.1. NM_001172178.1.
UniGeneiXl.573.

Genome annotation databases

GeneIDi100337563.
KEGGixla:100337563.

Similar proteinsi

Entry informationi

Entry nameiMPIP2_XENLA
AccessioniPrimary (citable) accession number: P30310
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: October 25, 2017
This is version 85 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families