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P30310 (MPIP2_XENLA) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 71. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
M-phase inducer phosphatase 2

EC=3.1.3.48
Gene names
Name:cdc25-2
OrganismXenopus laevis (African clawed frog)
Taxonomic identifier8355 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Protein attributes

Sequence length599 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

This protein functions as a dosage-dependent inducer in mitotic control. It is a tyrosine protein phosphatase required for progression of the cell cycle. It may directly dephosphorylate p34(cdc2) and activate the p34(cdc2) kinase activity.

Catalytic activity

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

Sequence similarities

Belongs to the MPI phosphatase family.

Contains 1 rhodanese domain.

Ontologies

Keywords
   Biological processCell cycle
Cell division
Mitosis
   Molecular functionHydrolase
Protein phosphatase
Gene Ontology (GO)
   Biological_processmitotic nuclear division

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentintracellular

Inferred from electronic annotation. Source: InterPro

   Molecular_functionprotein tyrosine phosphatase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 599599M-phase inducer phosphatase 2
PRO_0000198653

Regions

Domain450 – 557108Rhodanese

Sites

Active site5061 By similarity

Sequences

Sequence LengthMass (Da)Tools
P30310 [UniParc].

Last modified April 1, 1993. Version 1.
Checksum: DB93EBD979367C4C

FASTA59967,646
        10         20         30         40         50         60 
MYILLTLLTK STMESSCDNF EGLEHYYYTD AEPSSKCNKF QASGGSGVVM AESHIMSSEA 

        70         80         90        100        110        120 
PPKSNPGLNI RTNCRMILNL LREKDCSVTF SPEQPLTPVT DLAVGFSNLS TFSGETPKRC 

       130        140        150        160        170        180 
LDLSNLGDET APLPTESPDR MSSGKLESPK TQFVQFGGLF TPDLAWKAKK CPKRNMNSVL 

       190        200        210        220        230        240 
PHLLCSTPSF KKASGGQRSL SNKENEGELF KNPNCKPVAL LLPQEVVDSQ LSPTPENKVD 

       250        260        270        280        290        300 
ISLEEDCEMN ILGSPISADP PCLDGAHDDI KMQNLDGFAD FFSVDEEEME NPPGAVGNLS 

       310        320        330        340        350        360 
CSMAILLSGP LLNQDVEISN VNNISLNRSR LYRSPSMPEK LDRPMLKRPV RPLDSETPVR 

       370        380        390        400        410        420 
VKRRRSTSSP LQPEEENCQP QRRGTSLKKT LSLCDVDIST VLDEDCGHRQ LIGDFSKVYA 

       430        440        450        460        470        480 
LPTVTGRHQD LRYITGETLA ALMHGDFNSL VEKFFIIDCR YPYEYDGGHI KSAFNLHRQE 

       490        500        510        520        530        540 
EVTDYFLQQP LTPLMVQKRL IIIFHCEFSS ERGPKMCRFL REEDRASNDY PSLYYPELYL 

       550        560        570        580        590 
LKGGYKDFFP EYKELCEPQS YCPMHHQDFR EDLLKFRTKC KTSVGDRKRR EQVARLMKL 

« Hide

References

[1]"Regulation of the cdc25 protein during the cell cycle in Xenopus extracts."
Kumagai A., Dunphy W.G.
Cell 70:139-151(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Oocyte.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M94263 mRNA. Translation: AAA49673.1.
PIRI51405. B42679.
RefSeqNP_001165649.1. NM_001172178.1.
UniGeneXl.573.

3D structure databases

ProteinModelPortalP30310.
SMRP30310. Positions 411-571.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

MINTMINT-92088.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID100337563.
KEGGxla:100337563.

Organism-specific databases

CTD100337563.

Phylogenomic databases

HOVERGENHBG052501.
KOK05867.

Family and domain databases

Gene3D3.40.250.10. 1 hit.
InterProIPR000751. MPI_Phosphatase.
IPR001763. Rhodanese-like_dom.
[Graphical view]
PfamPF06617. M-inducer_phosp. 1 hit.
PF00581. Rhodanese. 1 hit.
[Graphical view]
PRINTSPR00716. MPIPHPHTASE.
SMARTSM00450. RHOD. 1 hit.
[Graphical view]
SUPFAMSSF52821. SSF52821. 1 hit.
PROSITEPS50206. RHODANESE_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMPIP2_XENLA
AccessionPrimary (citable) accession number: P30310
Entry history
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: April 16, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families