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P30310

- MPIP2_XENLA

UniProt

P30310 - MPIP2_XENLA

Protein

M-phase inducer phosphatase 2

Gene

cdc25-2

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 73 (01 Oct 2014)
      Sequence version 1 (01 Apr 1993)
      Previous versions | rss
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    Functioni

    This protein functions as a dosage-dependent inducer in mitotic control. It is a tyrosine protein phosphatase required for progression of the cell cycle. It may directly dephosphorylate p34(cdc2) and activate the p34(cdc2) kinase activity.

    Catalytic activityi

    Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei506 – 5061By similarity

    GO - Molecular functioni

    1. protein tyrosine phosphatase activity Source: UniProtKB-EC

    GO - Biological processi

    1. mitotic nuclear division Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Keywords - Biological processi

    Cell cycle, Cell division, Mitosis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    M-phase inducer phosphatase 2 (EC:3.1.3.48)
    Gene namesi
    Name:cdc25-2
    OrganismiXenopus laevis (African clawed frog)
    Taxonomic identifieri8355 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

    Subcellular locationi

    GO - Cellular componenti

    1. intracellular Source: InterPro

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 599599M-phase inducer phosphatase 2PRO_0000198653Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    MINTiMINT-92088.

    Structurei

    3D structure databases

    ProteinModelPortaliP30310.
    SMRiP30310. Positions 411-571.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini450 – 557108RhodanesePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the MPI phosphatase family.Curated
    Contains 1 rhodanese domain.PROSITE-ProRule annotation

    Phylogenomic databases

    HOVERGENiHBG052501.
    KOiK05867.

    Family and domain databases

    Gene3Di3.40.250.10. 1 hit.
    InterProiIPR000751. MPI_Phosphatase.
    IPR001763. Rhodanese-like_dom.
    [Graphical view]
    PfamiPF06617. M-inducer_phosp. 1 hit.
    PF00581. Rhodanese. 1 hit.
    [Graphical view]
    PRINTSiPR00716. MPIPHPHTASE.
    SMARTiSM00450. RHOD. 1 hit.
    [Graphical view]
    SUPFAMiSSF52821. SSF52821. 1 hit.
    PROSITEiPS50206. RHODANESE_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P30310-1 [UniParc]FASTAAdd to Basket

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    MYILLTLLTK STMESSCDNF EGLEHYYYTD AEPSSKCNKF QASGGSGVVM    50
    AESHIMSSEA PPKSNPGLNI RTNCRMILNL LREKDCSVTF SPEQPLTPVT 100
    DLAVGFSNLS TFSGETPKRC LDLSNLGDET APLPTESPDR MSSGKLESPK 150
    TQFVQFGGLF TPDLAWKAKK CPKRNMNSVL PHLLCSTPSF KKASGGQRSL 200
    SNKENEGELF KNPNCKPVAL LLPQEVVDSQ LSPTPENKVD ISLEEDCEMN 250
    ILGSPISADP PCLDGAHDDI KMQNLDGFAD FFSVDEEEME NPPGAVGNLS 300
    CSMAILLSGP LLNQDVEISN VNNISLNRSR LYRSPSMPEK LDRPMLKRPV 350
    RPLDSETPVR VKRRRSTSSP LQPEEENCQP QRRGTSLKKT LSLCDVDIST 400
    VLDEDCGHRQ LIGDFSKVYA LPTVTGRHQD LRYITGETLA ALMHGDFNSL 450
    VEKFFIIDCR YPYEYDGGHI KSAFNLHRQE EVTDYFLQQP LTPLMVQKRL 500
    IIIFHCEFSS ERGPKMCRFL REEDRASNDY PSLYYPELYL LKGGYKDFFP 550
    EYKELCEPQS YCPMHHQDFR EDLLKFRTKC KTSVGDRKRR EQVARLMKL 599
    Length:599
    Mass (Da):67,646
    Last modified:April 1, 1993 - v1
    Checksum:iDB93EBD979367C4C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M94263 mRNA. Translation: AAA49673.1.
    PIRiB42679. I51405.
    RefSeqiNP_001165649.1. NM_001172178.1.
    UniGeneiXl.573.

    Genome annotation databases

    GeneIDi100337563.
    KEGGixla:100337563.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M94263 mRNA. Translation: AAA49673.1 .
    PIRi B42679. I51405.
    RefSeqi NP_001165649.1. NM_001172178.1.
    UniGenei Xl.573.

    3D structure databases

    ProteinModelPortali P30310.
    SMRi P30310. Positions 411-571.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    MINTi MINT-92088.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 100337563.
    KEGGi xla:100337563.

    Organism-specific databases

    CTDi 100337563.

    Phylogenomic databases

    HOVERGENi HBG052501.
    KOi K05867.

    Family and domain databases

    Gene3Di 3.40.250.10. 1 hit.
    InterProi IPR000751. MPI_Phosphatase.
    IPR001763. Rhodanese-like_dom.
    [Graphical view ]
    Pfami PF06617. M-inducer_phosp. 1 hit.
    PF00581. Rhodanese. 1 hit.
    [Graphical view ]
    PRINTSi PR00716. MPIPHPHTASE.
    SMARTi SM00450. RHOD. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52821. SSF52821. 1 hit.
    PROSITEi PS50206. RHODANESE_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Regulation of the cdc25 protein during the cell cycle in Xenopus extracts."
      Kumagai A., Dunphy W.G.
      Cell 70:139-151(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Oocyte.

    Entry informationi

    Entry nameiMPIP2_XENLA
    AccessioniPrimary (citable) accession number: P30310
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 1, 1993
    Last sequence update: April 1, 1993
    Last modified: October 1, 2014
    This is version 73 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3