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Protein

M-phase inducer phosphatase 2

Gene

cdc25-2

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

This protein functions as a dosage-dependent inducer in mitotic control. It is a tyrosine protein phosphatase required for progression of the cell cycle. It may directly dephosphorylate p34(cdc2) and activate the p34(cdc2) kinase activity.

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei506 – 5061By similarity

GO - Molecular functioni

  1. protein tyrosine phosphatase activity Source: UniProtKB-EC

GO - Biological processi

  1. cell division Source: UniProtKB-KW
  2. mitotic nuclear division Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Biological processi

Cell cycle, Cell division, Mitosis

Names & Taxonomyi

Protein namesi
Recommended name:
M-phase inducer phosphatase 2 (EC:3.1.3.48)
Gene namesi
Name:cdc25-2
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Subcellular locationi

GO - Cellular componenti

  1. intracellular Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 599599M-phase inducer phosphatase 2PRO_0000198653Add
BLAST

Interactioni

Protein-protein interaction databases

MINTiMINT-92088.

Structurei

3D structure databases

ProteinModelPortaliP30310.
SMRiP30310. Positions 411-571.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini450 – 557108RhodanesePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the MPI phosphatase family.Curated
Contains 1 rhodanese domain.PROSITE-ProRule annotation

Phylogenomic databases

HOVERGENiHBG052501.
KOiK05867.

Family and domain databases

Gene3Di3.40.250.10. 1 hit.
InterProiIPR000751. MPI_Phosphatase.
IPR001763. Rhodanese-like_dom.
[Graphical view]
PfamiPF06617. M-inducer_phosp. 1 hit.
PF00581. Rhodanese. 1 hit.
[Graphical view]
PRINTSiPR00716. MPIPHPHTASE.
SMARTiSM00450. RHOD. 1 hit.
[Graphical view]
SUPFAMiSSF52821. SSF52821. 1 hit.
PROSITEiPS50206. RHODANESE_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P30310-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MYILLTLLTK STMESSCDNF EGLEHYYYTD AEPSSKCNKF QASGGSGVVM
60 70 80 90 100
AESHIMSSEA PPKSNPGLNI RTNCRMILNL LREKDCSVTF SPEQPLTPVT
110 120 130 140 150
DLAVGFSNLS TFSGETPKRC LDLSNLGDET APLPTESPDR MSSGKLESPK
160 170 180 190 200
TQFVQFGGLF TPDLAWKAKK CPKRNMNSVL PHLLCSTPSF KKASGGQRSL
210 220 230 240 250
SNKENEGELF KNPNCKPVAL LLPQEVVDSQ LSPTPENKVD ISLEEDCEMN
260 270 280 290 300
ILGSPISADP PCLDGAHDDI KMQNLDGFAD FFSVDEEEME NPPGAVGNLS
310 320 330 340 350
CSMAILLSGP LLNQDVEISN VNNISLNRSR LYRSPSMPEK LDRPMLKRPV
360 370 380 390 400
RPLDSETPVR VKRRRSTSSP LQPEEENCQP QRRGTSLKKT LSLCDVDIST
410 420 430 440 450
VLDEDCGHRQ LIGDFSKVYA LPTVTGRHQD LRYITGETLA ALMHGDFNSL
460 470 480 490 500
VEKFFIIDCR YPYEYDGGHI KSAFNLHRQE EVTDYFLQQP LTPLMVQKRL
510 520 530 540 550
IIIFHCEFSS ERGPKMCRFL REEDRASNDY PSLYYPELYL LKGGYKDFFP
560 570 580 590
EYKELCEPQS YCPMHHQDFR EDLLKFRTKC KTSVGDRKRR EQVARLMKL
Length:599
Mass (Da):67,646
Last modified:April 1, 1993 - v1
Checksum:iDB93EBD979367C4C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M94263 mRNA. Translation: AAA49673.1.
PIRiB42679. I51405.
RefSeqiNP_001165649.1. NM_001172178.1.
UniGeneiXl.573.

Genome annotation databases

GeneIDi100337563.
KEGGixla:100337563.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M94263 mRNA. Translation: AAA49673.1.
PIRiB42679. I51405.
RefSeqiNP_001165649.1. NM_001172178.1.
UniGeneiXl.573.

3D structure databases

ProteinModelPortaliP30310.
SMRiP30310. Positions 411-571.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-92088.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100337563.
KEGGixla:100337563.

Organism-specific databases

CTDi100337563.

Phylogenomic databases

HOVERGENiHBG052501.
KOiK05867.

Family and domain databases

Gene3Di3.40.250.10. 1 hit.
InterProiIPR000751. MPI_Phosphatase.
IPR001763. Rhodanese-like_dom.
[Graphical view]
PfamiPF06617. M-inducer_phosp. 1 hit.
PF00581. Rhodanese. 1 hit.
[Graphical view]
PRINTSiPR00716. MPIPHPHTASE.
SMARTiSM00450. RHOD. 1 hit.
[Graphical view]
SUPFAMiSSF52821. SSF52821. 1 hit.
PROSITEiPS50206. RHODANESE_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Regulation of the cdc25 protein during the cell cycle in Xenopus extracts."
    Kumagai A., Dunphy W.G.
    Cell 70:139-151(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Oocyte.

Entry informationi

Entry nameiMPIP2_XENLA
AccessioniPrimary (citable) accession number: P30310
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: February 4, 2015
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.