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P30309 (MPI1B_XENLA) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 79. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
M-phase inducer phosphatase 1-B

EC=3.1.3.48
Gene names
Name:cdc25-1-b
Synonyms:cdc25b
OrganismXenopus laevis (African clawed frog)
Taxonomic identifier8355 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Protein attributes

Sequence length550 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

This protein functions as a dosage-dependent inducer in mitotic control. It is a tyrosine protein phosphatase required for progression of the cell cycle. It may directly dephosphorylate p34(cdc2) and activate the p34(cdc2) kinase activity.

Catalytic activity

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

Sequence similarities

Belongs to the MPI phosphatase family.

Contains 1 rhodanese domain.

Ontologies

Keywords
   Biological processCell cycle
Cell division
Mitosis
   Molecular functionHydrolase
Protein phosphatase
Gene Ontology (GO)
   Biological_processmitotic nuclear division

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentintracellular

Inferred from electronic annotation. Source: InterPro

   Molecular_functionprotein tyrosine phosphatase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 550550M-phase inducer phosphatase 1-B
PRO_0000198652

Regions

Domain401 – 508108Rhodanese

Sites

Active site4571 By similarity

Sequences

Sequence LengthMass (Da)Tools
P30309 [UniParc].

Last modified April 1, 1993. Version 1.
Checksum: FCEC83AB66FCC5B0

FASTA55062,183
        10         20         30         40         50         60 
MAESHIMSSE APPKTNTGLN FRTNCRMVLN LLREKDCSVT FSPEQPLTPV TDLAVGFSNL 

        70         80         90        100        110        120 
STFSGETPKR CLDLSNLGDE TAPLPTESPD RISSGKVESP KAQFVQFDGL FTPDLGWKAK 

       130        140        150        160        170        180 
KCPRGNMNSV LPRLLCSTPS FKKTSGGQRS VSNKENEGEL FKSPNCKPVA LLLPQEVVDS 

       190        200        210        220        230        240 
QFSPTPENKV DISLDEDCEM NILGSPISAD PPCLDGAHDD IKMQNLDGFA DFFSVDEEEM 

       250        260        270        280        290        300 
ENPPGAVGNL SSSMAILLSG PLLNQDIEVS NVNNISLNRS RLYRSPSMPE KLDRPMLKRP 

       310        320        330        340        350        360 
VRPLDSETPV RVKRRRSTSS SLQPQEENFQ PQRRGTSLKK TLSLCDVDIS TVLDEDCGHR 

       370        380        390        400        410        420 
QLIGDFTKVY ALPTVTGRHQ DLRYITGETL AALIHGDFSS LVEKIFIIDC RYPYEYDGGH 

       430        440        450        460        470        480 
IKGALNLHRQ EEVTDYFLKQ PLTPTMAQKR LIIIFHCEFS SERGPKMCRF LREEDRARNE 

       490        500        510        520        530        540 
YPSLYYPELY LLKGGYKDFF PEYKELCEPQ SYCPMHHQDF REELLKFRTK CKTSVGDRKR 

       550 
REQIARIMKL 

« Hide

References

[1]"Regulation of the cdc25 protein during the cell cycle in Xenopus extracts."
Kumagai A., Dunphy W.G.
Cell 70:139-151(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Oocyte.
[2]"Periodic changes in phosphorylation of the Xenopus cdc25 phosphatase regulate its activity."
Izumi T., Walker D.H., Maller J.L.
Mol. Biol. Cell 3:927-939(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M94262 mRNA. Translation: AAA49671.1.
M96858 mRNA. Translation: AAA49674.1.
PIRA42679.
RefSeqNP_001081918.1. NM_001088449.1.
UniGeneXl.513.

3D structure databases

ProteinModelPortalP30309.
SMRP30309. Positions 362-522.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

DIPDIP-176N.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID398119.
KEGGxla:398119.

Organism-specific databases

CTD398119.
XenbaseXB-GENE-944825. cdc25c.

Phylogenomic databases

HOVERGENHBG052501.
KOK05867.

Family and domain databases

Gene3D3.40.250.10. 1 hit.
InterProIPR000751. MPI_Phosphatase.
IPR001763. Rhodanese-like_dom.
[Graphical view]
PfamPF06617. M-inducer_phosp. 1 hit.
PF00581. Rhodanese. 1 hit.
[Graphical view]
PRINTSPR00716. MPIPHPHTASE.
SMARTSM00450. RHOD. 1 hit.
[Graphical view]
SUPFAMSSF52821. SSF52821. 1 hit.
PROSITEPS50206. RHODANESE_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMPI1B_XENLA
AccessionPrimary (citable) accession number: P30309
Entry history
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: April 16, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families