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P30309

- MPI1B_XENLA

UniProt

P30309 - MPI1B_XENLA

Protein

M-phase inducer phosphatase 1-B

Gene

cdc25-1-b

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 81 (01 Oct 2014)
      Sequence version 1 (01 Apr 1993)
      Previous versions | rss
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    Functioni

    This protein functions as a dosage-dependent inducer in mitotic control. It is a tyrosine protein phosphatase required for progression of the cell cycle. It may directly dephosphorylate p34(cdc2) and activate the p34(cdc2) kinase activity.

    Catalytic activityi

    Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei457 – 4571By similarity

    GO - Molecular functioni

    1. protein tyrosine phosphatase activity Source: UniProtKB-EC

    GO - Biological processi

    1. mitotic nuclear division Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Keywords - Biological processi

    Cell cycle, Cell division, Mitosis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    M-phase inducer phosphatase 1-B (EC:3.1.3.48)
    Gene namesi
    Name:cdc25-1-b
    Synonyms:cdc25b
    OrganismiXenopus laevis (African clawed frog)
    Taxonomic identifieri8355 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

    Organism-specific databases

    XenbaseiXB-GENE-944825. cdc25c.

    Subcellular locationi

    GO - Cellular componenti

    1. intracellular Source: InterPro

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 550550M-phase inducer phosphatase 1-BPRO_0000198652Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    DIPiDIP-176N.

    Structurei

    3D structure databases

    ProteinModelPortaliP30309.
    SMRiP30309. Positions 362-522.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini401 – 508108RhodanesePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the MPI phosphatase family.Curated
    Contains 1 rhodanese domain.PROSITE-ProRule annotation

    Phylogenomic databases

    HOVERGENiHBG052501.
    KOiK05867.

    Family and domain databases

    Gene3Di3.40.250.10. 1 hit.
    InterProiIPR000751. MPI_Phosphatase.
    IPR001763. Rhodanese-like_dom.
    [Graphical view]
    PfamiPF06617. M-inducer_phosp. 1 hit.
    PF00581. Rhodanese. 1 hit.
    [Graphical view]
    PRINTSiPR00716. MPIPHPHTASE.
    SMARTiSM00450. RHOD. 1 hit.
    [Graphical view]
    SUPFAMiSSF52821. SSF52821. 1 hit.
    PROSITEiPS50206. RHODANESE_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P30309-1 [UniParc]FASTAAdd to Basket

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    MAESHIMSSE APPKTNTGLN FRTNCRMVLN LLREKDCSVT FSPEQPLTPV    50
    TDLAVGFSNL STFSGETPKR CLDLSNLGDE TAPLPTESPD RISSGKVESP 100
    KAQFVQFDGL FTPDLGWKAK KCPRGNMNSV LPRLLCSTPS FKKTSGGQRS 150
    VSNKENEGEL FKSPNCKPVA LLLPQEVVDS QFSPTPENKV DISLDEDCEM 200
    NILGSPISAD PPCLDGAHDD IKMQNLDGFA DFFSVDEEEM ENPPGAVGNL 250
    SSSMAILLSG PLLNQDIEVS NVNNISLNRS RLYRSPSMPE KLDRPMLKRP 300
    VRPLDSETPV RVKRRRSTSS SLQPQEENFQ PQRRGTSLKK TLSLCDVDIS 350
    TVLDEDCGHR QLIGDFTKVY ALPTVTGRHQ DLRYITGETL AALIHGDFSS 400
    LVEKIFIIDC RYPYEYDGGH IKGALNLHRQ EEVTDYFLKQ PLTPTMAQKR 450
    LIIIFHCEFS SERGPKMCRF LREEDRARNE YPSLYYPELY LLKGGYKDFF 500
    PEYKELCEPQ SYCPMHHQDF REELLKFRTK CKTSVGDRKR REQIARIMKL 550
    Length:550
    Mass (Da):62,183
    Last modified:April 1, 1993 - v1
    Checksum:iFCEC83AB66FCC5B0
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M94262 mRNA. Translation: AAA49671.1.
    M96858 mRNA. Translation: AAA49674.1.
    PIRiA42679.
    RefSeqiNP_001081918.1. NM_001088449.1.
    UniGeneiXl.513.

    Genome annotation databases

    GeneIDi398119.
    KEGGixla:398119.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M94262 mRNA. Translation: AAA49671.1 .
    M96858 mRNA. Translation: AAA49674.1 .
    PIRi A42679.
    RefSeqi NP_001081918.1. NM_001088449.1.
    UniGenei Xl.513.

    3D structure databases

    ProteinModelPortali P30309.
    SMRi P30309. Positions 362-522.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-176N.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 398119.
    KEGGi xla:398119.

    Organism-specific databases

    CTDi 398119.
    Xenbasei XB-GENE-944825. cdc25c.

    Phylogenomic databases

    HOVERGENi HBG052501.
    KOi K05867.

    Family and domain databases

    Gene3Di 3.40.250.10. 1 hit.
    InterProi IPR000751. MPI_Phosphatase.
    IPR001763. Rhodanese-like_dom.
    [Graphical view ]
    Pfami PF06617. M-inducer_phosp. 1 hit.
    PF00581. Rhodanese. 1 hit.
    [Graphical view ]
    PRINTSi PR00716. MPIPHPHTASE.
    SMARTi SM00450. RHOD. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52821. SSF52821. 1 hit.
    PROSITEi PS50206. RHODANESE_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Regulation of the cdc25 protein during the cell cycle in Xenopus extracts."
      Kumagai A., Dunphy W.G.
      Cell 70:139-151(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Oocyte.
    2. "Periodic changes in phosphorylation of the Xenopus cdc25 phosphatase regulate its activity."
      Izumi T., Walker D.H., Maller J.L.
      Mol. Biol. Cell 3:927-939(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiMPI1B_XENLA
    AccessioniPrimary (citable) accession number: P30309
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 1, 1993
    Last sequence update: April 1, 1993
    Last modified: October 1, 2014
    This is version 81 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3