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P30308

- MPI1A_XENLA

UniProt

P30308 - MPI1A_XENLA

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Protein
M-phase inducer phosphatase 1-A
Gene
cdc25-1-a, cdc25a
Organism
Xenopus laevis (African clawed frog)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

This protein functions as a dosage-dependent inducer in mitotic control. It is a tyrosine protein phosphatase required for progression of the cell cycle. It may directly dephosphorylate p34(cdc2) and activate the p34(cdc2) kinase activity.

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei457 – 4571 By similarity

GO - Molecular functioni

  1. protein tyrosine phosphatase activity Source: UniProtKB-EC

GO - Biological processi

  1. mitotic nuclear division Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Biological processi

Cell cycle, Cell division, Mitosis

Names & Taxonomyi

Protein namesi
Recommended name:
M-phase inducer phosphatase 1-A (EC:3.1.3.48)
Gene namesi
Name:cdc25-1-a
Synonyms:cdc25a
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Subcellular locationi

GO - Cellular componenti

  1. intracellular Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 550550M-phase inducer phosphatase 1-A
PRO_0000198651Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP30308.
SMRiP30308. Positions 362-522.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini401 – 508108Rhodanese
Add
BLAST

Sequence similaritiesi

Belongs to the MPI phosphatase family.
Contains 1 rhodanese domain.

Phylogenomic databases

HOVERGENiHBG052501.

Family and domain databases

Gene3Di3.40.250.10. 1 hit.
InterProiIPR000751. MPI_Phosphatase.
IPR001763. Rhodanese-like_dom.
[Graphical view]
PfamiPF06617. M-inducer_phosp. 1 hit.
PF00581. Rhodanese. 1 hit.
[Graphical view]
PRINTSiPR00716. MPIPHPHTASE.
SMARTiSM00450. RHOD. 1 hit.
[Graphical view]
SUPFAMiSSF52821. SSF52821. 1 hit.
PROSITEiPS50206. RHODANESE_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P30308-1 [UniParc]FASTAAdd to Basket

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MAESHIMSSE APPKSNTGLN IRTNCRMILN LLREKDCSVT FSPEQPLTPV    50
TDLAVGFSNL STFSGETPKR CLDLSNLGDE TAPLPTESPD RMSSGKLESP 100
KTQFVQFDGL FTPDLAWKAK KCPKRNMNSV LPHLLCSTPS FKKASGGQRS 150
LSNKENEGEL FKNPNCKPVA LLLPQEVVDS QLSPTPENKV DISLEEDCEM 200
NILGSPISAD PPCLDGAHDD IKMQNLDGFA DFFSVDEEEM ENPPGAVGNL 250
SCSMAILLSG PLLNQDVEIS NVNNISLNRS RLYRSPSMPE KLDRPMLKRP 300
VRPLDSETPV RVKRRRSTSS PLQPEEENCQ PQRRGTSLKK TLSLCDVDIS 350
TVLDEDCGHR QLIGDFSKVY ALPTVTGRHQ DLRYITGETL AALMHGDFNS 400
LVEKFFIIDC RYPYEYDGGH IKSAFNLHRQ EEVTDYFLQQ PLTPLMVQKR 450
LIIIFHCEFS SERGPKMCRF LREEDRASND YPSLYYPELY LLKGGYKDFF 500
PEYKELCEPQ SYCPMHHQDF REDLLKFRTK CKTSVGDRKR REQVARLMKL 550
Length:550
Mass (Da):62,309
Last modified:April 1, 1993 - v1
Checksum:i407B3B7AD8EC7216
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M96857 mRNA. Translation: AAA49672.1.
UniGeneiXl.573.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M96857 mRNA. Translation: AAA49672.1 .
UniGenei Xl.573.

3D structure databases

ProteinModelPortali P30308.
SMRi P30308. Positions 362-522.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOVERGENi HBG052501.

Family and domain databases

Gene3Di 3.40.250.10. 1 hit.
InterProi IPR000751. MPI_Phosphatase.
IPR001763. Rhodanese-like_dom.
[Graphical view ]
Pfami PF06617. M-inducer_phosp. 1 hit.
PF00581. Rhodanese. 1 hit.
[Graphical view ]
PRINTSi PR00716. MPIPHPHTASE.
SMARTi SM00450. RHOD. 1 hit.
[Graphical view ]
SUPFAMi SSF52821. SSF52821. 1 hit.
PROSITEi PS50206. RHODANESE_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Periodic changes in phosphorylation of the Xenopus cdc25 phosphatase regulate its activity."
    Izumi T., Walker D.H., Maller J.L.
    Mol. Biol. Cell 3:927-939(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiMPI1A_XENLA
AccessioniPrimary (citable) accession number: P30308
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: September 3, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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