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P30308 (MPI1A_XENLA) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 73. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
M-phase inducer phosphatase 1-A

EC=3.1.3.48
Gene names
Name:cdc25-1-a
Synonyms:cdc25a
OrganismXenopus laevis (African clawed frog)
Taxonomic identifier8355 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Protein attributes

Sequence length550 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

This protein functions as a dosage-dependent inducer in mitotic control. It is a tyrosine protein phosphatase required for progression of the cell cycle. It may directly dephosphorylate p34(cdc2) and activate the p34(cdc2) kinase activity.

Catalytic activity

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

Sequence similarities

Belongs to the MPI phosphatase family.

Contains 1 rhodanese domain.

Ontologies

Keywords
   Biological processCell cycle
Cell division
Mitosis
   Molecular functionHydrolase
Protein phosphatase
Gene Ontology (GO)
   Biological_processmitosis

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentintracellular

Inferred from electronic annotation. Source: InterPro

   Molecular_functionprotein tyrosine phosphatase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 550550M-phase inducer phosphatase 1-A
PRO_0000198651

Regions

Domain401 – 508108Rhodanese

Sites

Active site4571 By similarity

Sequences

Sequence LengthMass (Da)Tools
P30308 [UniParc].

Last modified April 1, 1993. Version 1.
Checksum: 407B3B7AD8EC7216

FASTA55062,309
        10         20         30         40         50         60 
MAESHIMSSE APPKSNTGLN IRTNCRMILN LLREKDCSVT FSPEQPLTPV TDLAVGFSNL 

        70         80         90        100        110        120 
STFSGETPKR CLDLSNLGDE TAPLPTESPD RMSSGKLESP KTQFVQFDGL FTPDLAWKAK 

       130        140        150        160        170        180 
KCPKRNMNSV LPHLLCSTPS FKKASGGQRS LSNKENEGEL FKNPNCKPVA LLLPQEVVDS 

       190        200        210        220        230        240 
QLSPTPENKV DISLEEDCEM NILGSPISAD PPCLDGAHDD IKMQNLDGFA DFFSVDEEEM 

       250        260        270        280        290        300 
ENPPGAVGNL SCSMAILLSG PLLNQDVEIS NVNNISLNRS RLYRSPSMPE KLDRPMLKRP 

       310        320        330        340        350        360 
VRPLDSETPV RVKRRRSTSS PLQPEEENCQ PQRRGTSLKK TLSLCDVDIS TVLDEDCGHR 

       370        380        390        400        410        420 
QLIGDFSKVY ALPTVTGRHQ DLRYITGETL AALMHGDFNS LVEKFFIIDC RYPYEYDGGH 

       430        440        450        460        470        480 
IKSAFNLHRQ EEVTDYFLQQ PLTPLMVQKR LIIIFHCEFS SERGPKMCRF LREEDRASND 

       490        500        510        520        530        540 
YPSLYYPELY LLKGGYKDFF PEYKELCEPQ SYCPMHHQDF REDLLKFRTK CKTSVGDRKR 

       550 
REQVARLMKL 

« Hide

References

[1]"Periodic changes in phosphorylation of the Xenopus cdc25 phosphatase regulate its activity."
Izumi T., Walker D.H., Maller J.L.
Mol. Biol. Cell 3:927-939(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M96857 mRNA. Translation: AAA49672.1.
UniGeneXl.573.

3D structure databases

ProteinModelPortalP30308.
SMRP30308. Positions 362-522.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

HOVERGENHBG052501.

Family and domain databases

Gene3D3.40.250.10. 1 hit.
InterProIPR000751. MPI_Phosphatase.
IPR001763. Rhodanese-like_dom.
[Graphical view]
PfamPF06617. M-inducer_phosp. 1 hit.
PF00581. Rhodanese. 1 hit.
[Graphical view]
PRINTSPR00716. MPIPHPHTASE.
SMARTSM00450. RHOD. 1 hit.
[Graphical view]
SUPFAMSSF52821. SSF52821. 1 hit.
PROSITEPS50206. RHODANESE_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMPI1A_XENLA
AccessionPrimary (citable) accession number: P30308
Entry history
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: April 16, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families