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Protein

M-phase inducer phosphatase 1-A

Gene

cdc25-1-a

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

This protein functions as a dosage-dependent inducer in mitotic control. It is a tyrosine protein phosphatase required for progression of the cell cycle. It may directly dephosphorylate p34(cdc2) and activate the p34(cdc2) kinase activity.

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei457 – 4571By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Biological processi

Cell cycle, Cell division, Mitosis

Names & Taxonomyi

Protein namesi
Recommended name:
M-phase inducer phosphatase 1-A (EC:3.1.3.48)
Gene namesi
Name:cdc25-1-a
Synonyms:cdc25a
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 550550M-phase inducer phosphatase 1-APRO_0000198651Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP30308.
SMRiP30308. Positions 362-522.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini401 – 508108RhodanesePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the MPI phosphatase family.Curated
Contains 1 rhodanese domain.PROSITE-ProRule annotation

Phylogenomic databases

HOVERGENiHBG052501.

Family and domain databases

Gene3Di3.40.250.10. 1 hit.
InterProiIPR000751. MPI_Phosphatase.
IPR001763. Rhodanese-like_dom.
[Graphical view]
PfamiPF06617. M-inducer_phosp. 1 hit.
PF00581. Rhodanese. 1 hit.
[Graphical view]
PRINTSiPR00716. MPIPHPHTASE.
SMARTiSM00450. RHOD. 1 hit.
[Graphical view]
SUPFAMiSSF52821. SSF52821. 1 hit.
PROSITEiPS50206. RHODANESE_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P30308-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAESHIMSSE APPKSNTGLN IRTNCRMILN LLREKDCSVT FSPEQPLTPV
60 70 80 90 100
TDLAVGFSNL STFSGETPKR CLDLSNLGDE TAPLPTESPD RMSSGKLESP
110 120 130 140 150
KTQFVQFDGL FTPDLAWKAK KCPKRNMNSV LPHLLCSTPS FKKASGGQRS
160 170 180 190 200
LSNKENEGEL FKNPNCKPVA LLLPQEVVDS QLSPTPENKV DISLEEDCEM
210 220 230 240 250
NILGSPISAD PPCLDGAHDD IKMQNLDGFA DFFSVDEEEM ENPPGAVGNL
260 270 280 290 300
SCSMAILLSG PLLNQDVEIS NVNNISLNRS RLYRSPSMPE KLDRPMLKRP
310 320 330 340 350
VRPLDSETPV RVKRRRSTSS PLQPEEENCQ PQRRGTSLKK TLSLCDVDIS
360 370 380 390 400
TVLDEDCGHR QLIGDFSKVY ALPTVTGRHQ DLRYITGETL AALMHGDFNS
410 420 430 440 450
LVEKFFIIDC RYPYEYDGGH IKSAFNLHRQ EEVTDYFLQQ PLTPLMVQKR
460 470 480 490 500
LIIIFHCEFS SERGPKMCRF LREEDRASND YPSLYYPELY LLKGGYKDFF
510 520 530 540 550
PEYKELCEPQ SYCPMHHQDF REDLLKFRTK CKTSVGDRKR REQVARLMKL
Length:550
Mass (Da):62,309
Last modified:April 1, 1993 - v1
Checksum:i407B3B7AD8EC7216
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M96857 mRNA. Translation: AAA49672.1.
UniGeneiXl.573.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M96857 mRNA. Translation: AAA49672.1.
UniGeneiXl.573.

3D structure databases

ProteinModelPortaliP30308.
SMRiP30308. Positions 362-522.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG052501.

Family and domain databases

Gene3Di3.40.250.10. 1 hit.
InterProiIPR000751. MPI_Phosphatase.
IPR001763. Rhodanese-like_dom.
[Graphical view]
PfamiPF06617. M-inducer_phosp. 1 hit.
PF00581. Rhodanese. 1 hit.
[Graphical view]
PRINTSiPR00716. MPIPHPHTASE.
SMARTiSM00450. RHOD. 1 hit.
[Graphical view]
SUPFAMiSSF52821. SSF52821. 1 hit.
PROSITEiPS50206. RHODANESE_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Periodic changes in phosphorylation of the Xenopus cdc25 phosphatase regulate its activity."
    Izumi T., Walker D.H., Maller J.L.
    Mol. Biol. Cell 3:927-939(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiMPI1A_XENLA
AccessioniPrimary (citable) accession number: P30308
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: February 4, 2015
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.