SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P30303

- MPIP_EMENI

UniProt

P30303 - MPIP_EMENI

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
M-phase inducer phosphatase
Gene
nimT, AN3941
Organism
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

This protein functions as a dosage-dependent inducer in mitotic control. It is a tyrosine protein phosphatase required for progression of the cell cycle. It may directly dephosphorylate p34(cdc2) and activate the p34(cdc2) kinase activity.

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei421 – 4211 By similarity

GO - Molecular functioni

  1. protein tyrosine phosphatase activity Source: ASPGD
Complete GO annotation...

GO - Biological processi

  1. G2/M transition of mitotic cell cycle Source: ASPGD
  2. mitotic nuclear division Source: UniProtKB-KW
  3. peptidyl-tyrosine dephosphorylation Source: GOC
  4. positive regulation of mitosis Source: ASPGD
  5. regulation of cyclin-dependent protein serine/threonine kinase activity Source: ASPGD
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Biological processi

Cell cycle, Cell division, Mitosis

Names & Taxonomyi

Protein namesi
Recommended name:
M-phase inducer phosphatase (EC:3.1.3.48)
Gene namesi
Name:nimT
ORF Names:AN3941
OrganismiEmericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Taxonomic identifieri227321 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
ProteomesiUP000000560: Chromosome II

Subcellular locationi

GO - Cellular componenti

  1. intracellular Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 556556M-phase inducer phosphatase
PRO_0000198660Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi162425.CADANIAP00004753.

Structurei

3D structure databases

ProteinModelPortaliP30303.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini371 – 474104Rhodanese
Add
BLAST

Sequence similaritiesi

Belongs to the MPI phosphatase family.
Contains 1 rhodanese domain.

Phylogenomic databases

eggNOGiCOG5105.
HOGENOMiHOG000215320.
KOiK02555.
OMAiQRTCERE.
OrthoDBiEOG7VMPGR.

Family and domain databases

Gene3Di3.40.250.10. 1 hit.
InterProiIPR000751. MPI_Phosphatase.
IPR001763. Rhodanese-like_dom.
[Graphical view]
PfamiPF00581. Rhodanese. 1 hit.
[Graphical view]
PRINTSiPR00716. MPIPHPHTASE.
SMARTiSM00450. RHOD. 1 hit.
[Graphical view]
SUPFAMiSSF52821. SSF52821. 1 hit.
PROSITEiPS50206. RHODANESE_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P30303-1 [UniParc]FASTAAdd to Basket

« Hide

MEHSSPLAAM QPPSVMLGHC FRSDAPTSYH GFSPLPGLGP GGFNFKDLSM    50
KRSNGDYFGT KVVRGSSPTA SLAADLSQNF HIDQSPQVAT PRRSLFSACL 100
LGNGNRRGVD DAMTTPPLPS SSPAPAMDIM DMSPLPHKPP FISTPEIELD 150
SPTLESSPMD TTMMSTDGLV PDSPTVLPKD GKQERRRPTF LRPSLARSKA 200
QSFQVGMTRP APESQGPPFK FQTNGINKTS SGVAASLEDM FGESPQRERP 250
MMRINSTSGL NSRLRPPLGS GSHVRGNGSP SAASVRKSAH PNMRPRKQCR 300
RSLSMYEHPE DVIADSEVSY TSNAPLQSIS DFEETQALQL PHFIPEEQAD 350
NLPRIDKATL VDIKEGKYDN MFDNIMIIDC RFEYEYDGGH IVGAVNYNDK 400
ENLAAELFAD PKPRTAIVFH CEYSVHRAPL MAKYIRHRDR AYNVDHYPQL 450
SYPDMYILEG GYSGFFAEHR SLCYPQNYVE MSAKEHEFAC ERGLGKVKQR 500
SKLSRAQTFA FGQQSPEMED SPTGRCRNNP GDRKLLASPF NDSPGSRFPG 550
RRMLSY 556
Length:556
Mass (Da):61,626
Last modified:May 1, 2007 - v2
Checksum:iF558E77944A0BA59
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti353 – 3531P → G in CAA45885. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X64601 mRNA. Translation: CAA45885.1.
AACD01000064 Genomic DNA. Translation: EAA59250.1.
BN001302 Genomic DNA. Translation: CBF75046.1.
PIRiS24395.
RefSeqiXP_661545.1. XM_656453.1.

Genome annotation databases

EnsemblFungiiCADANIAT00004753; CADANIAP00004753; CADANIAG00004753.
GeneIDi2873361.
KEGGiani:AN3941.2.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X64601 mRNA. Translation: CAA45885.1 .
AACD01000064 Genomic DNA. Translation: EAA59250.1 .
BN001302 Genomic DNA. Translation: CBF75046.1 .
PIRi S24395.
RefSeqi XP_661545.1. XM_656453.1.

3D structure databases

ProteinModelPortali P30303.
ModBasei Search...

Protein-protein interaction databases

STRINGi 162425.CADANIAP00004753.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii CADANIAT00004753 ; CADANIAP00004753 ; CADANIAG00004753 .
GeneIDi 2873361.
KEGGi ani:AN3941.2.

Phylogenomic databases

eggNOGi COG5105.
HOGENOMi HOG000215320.
KOi K02555.
OMAi QRTCERE.
OrthoDBi EOG7VMPGR.

Family and domain databases

Gene3Di 3.40.250.10. 1 hit.
InterProi IPR000751. MPI_Phosphatase.
IPR001763. Rhodanese-like_dom.
[Graphical view ]
Pfami PF00581. Rhodanese. 1 hit.
[Graphical view ]
PRINTSi PR00716. MPIPHPHTASE.
SMARTi SM00450. RHOD. 1 hit.
[Graphical view ]
SUPFAMi SSF52821. SSF52821. 1 hit.
PROSITEi PS50206. RHODANESE_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "An extra copy of nimEcyclinB elevates pre-MPF levels and partially suppresses mutation of nimTcdc25 in Aspergillus nidulans."
    O'Connell M.J., Osmani A.H., Morris N.R., Osmani S.A.
    EMBO J. 11:2139-2149(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: GB20.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.
  3. "The 2008 update of the Aspergillus nidulans genome annotation: a community effort."
    Wortman J.R., Gilsenan J.M., Joardar V., Deegan J., Clutterbuck J., Andersen M.R., Archer D., Bencina M., Braus G., Coutinho P., von Dohren H., Doonan J., Driessen A.J., Durek P., Espeso E., Fekete E., Flipphi M., Estrada C.G.
    , Geysens S., Goldman G., de Groot P.W., Hansen K., Harris S.D., Heinekamp T., Helmstaedt K., Henrissat B., Hofmann G., Homan T., Horio T., Horiuchi H., James S., Jones M., Karaffa L., Karanyi Z., Kato M., Keller N., Kelly D.E., Kiel J.A., Kim J.M., van der Klei I.J., Klis F.M., Kovalchuk A., Krasevec N., Kubicek C.P., Liu B., Maccabe A., Meyer V., Mirabito P., Miskei M., Mos M., Mullins J., Nelson D.R., Nielsen J., Oakley B.R., Osmani S.A., Pakula T., Paszewski A., Paulsen I., Pilsyk S., Pocsi I., Punt P.J., Ram A.F., Ren Q., Robellet X., Robson G., Seiboth B., van Solingen P., Specht T., Sun J., Taheri-Talesh N., Takeshita N., Ussery D., vanKuyk P.A., Visser H., van de Vondervoort P.J., de Vries R.P., Walton J., Xiang X., Xiong Y., Zeng A.P., Brandt B.W., Cornell M.J., van den Hondel C.A., Visser J., Oliver S.G., Turner G.
    Fungal Genet. Biol. 46:S2-13(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENOME REANNOTATION.
    Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.

Entry informationi

Entry nameiMPIP_EMENI
AccessioniPrimary (citable) accession number: P30303
Secondary accession number(s): C8V635, Q5B689
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: May 1, 2007
Last modified: September 3, 2014
This is version 88 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi