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P30303 (MPIP_EMENI) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 87. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
M-phase inducer phosphatase

EC=3.1.3.48
Gene names
Name:nimT
ORF Names:AN3941
OrganismEmericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans) [Reference proteome]
Taxonomic identifier227321 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus

Protein attributes

Sequence length556 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

This protein functions as a dosage-dependent inducer in mitotic control. It is a tyrosine protein phosphatase required for progression of the cell cycle. It may directly dephosphorylate p34(cdc2) and activate the p34(cdc2) kinase activity.

Catalytic activity

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

Sequence similarities

Belongs to the MPI phosphatase family.

Contains 1 rhodanese domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 556556M-phase inducer phosphatase
PRO_0000198660

Regions

Domain371 – 474104Rhodanese

Sites

Active site4211 By similarity

Experimental info

Sequence conflict3531P → G in CAA45885. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P30303 [UniParc].

Last modified May 1, 2007. Version 2.
Checksum: F558E77944A0BA59

FASTA55661,626
        10         20         30         40         50         60 
MEHSSPLAAM QPPSVMLGHC FRSDAPTSYH GFSPLPGLGP GGFNFKDLSM KRSNGDYFGT 

        70         80         90        100        110        120 
KVVRGSSPTA SLAADLSQNF HIDQSPQVAT PRRSLFSACL LGNGNRRGVD DAMTTPPLPS 

       130        140        150        160        170        180 
SSPAPAMDIM DMSPLPHKPP FISTPEIELD SPTLESSPMD TTMMSTDGLV PDSPTVLPKD 

       190        200        210        220        230        240 
GKQERRRPTF LRPSLARSKA QSFQVGMTRP APESQGPPFK FQTNGINKTS SGVAASLEDM 

       250        260        270        280        290        300 
FGESPQRERP MMRINSTSGL NSRLRPPLGS GSHVRGNGSP SAASVRKSAH PNMRPRKQCR 

       310        320        330        340        350        360 
RSLSMYEHPE DVIADSEVSY TSNAPLQSIS DFEETQALQL PHFIPEEQAD NLPRIDKATL 

       370        380        390        400        410        420 
VDIKEGKYDN MFDNIMIIDC RFEYEYDGGH IVGAVNYNDK ENLAAELFAD PKPRTAIVFH 

       430        440        450        460        470        480 
CEYSVHRAPL MAKYIRHRDR AYNVDHYPQL SYPDMYILEG GYSGFFAEHR SLCYPQNYVE 

       490        500        510        520        530        540 
MSAKEHEFAC ERGLGKVKQR SKLSRAQTFA FGQQSPEMED SPTGRCRNNP GDRKLLASPF 

       550 
NDSPGSRFPG RRMLSY 

« Hide

References

« Hide 'large scale' references
[1]"An extra copy of nimEcyclinB elevates pre-MPF levels and partially suppresses mutation of nimTcdc25 in Aspergillus nidulans."
O'Connell M.J., Osmani A.H., Morris N.R., Osmani S.A.
EMBO J. 11:2139-2149(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: GB20.
[2]"Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae."
Galagan J.E., Calvo S.E., Cuomo C., Ma L.-J., Wortman J.R., Batzoglou S., Lee S.-I., Bastuerkmen M., Spevak C.C., Clutterbuck J., Kapitonov V., Jurka J., Scazzocchio C., Farman M.L., Butler J., Purcell S., Harris S., Braus G.H. expand/collapse author list , Draht O., Busch S., D'Enfert C., Bouchier C., Goldman G.H., Bell-Pedersen D., Griffiths-Jones S., Doonan J.H., Yu J., Vienken K., Pain A., Freitag M., Selker E.U., Archer D.B., Penalva M.A., Oakley B.R., Momany M., Tanaka T., Kumagai T., Asai K., Machida M., Nierman W.C., Denning D.W., Caddick M.X., Hynes M., Paoletti M., Fischer R., Miller B.L., Dyer P.S., Sachs M.S., Osmani S.A., Birren B.W.
Nature 438:1105-1115(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.
[3]"The 2008 update of the Aspergillus nidulans genome annotation: a community effort."
Wortman J.R., Gilsenan J.M., Joardar V., Deegan J., Clutterbuck J., Andersen M.R., Archer D., Bencina M., Braus G., Coutinho P., von Dohren H., Doonan J., Driessen A.J., Durek P., Espeso E., Fekete E., Flipphi M., Estrada C.G. expand/collapse author list , Geysens S., Goldman G., de Groot P.W., Hansen K., Harris S.D., Heinekamp T., Helmstaedt K., Henrissat B., Hofmann G., Homan T., Horio T., Horiuchi H., James S., Jones M., Karaffa L., Karanyi Z., Kato M., Keller N., Kelly D.E., Kiel J.A., Kim J.M., van der Klei I.J., Klis F.M., Kovalchuk A., Krasevec N., Kubicek C.P., Liu B., Maccabe A., Meyer V., Mirabito P., Miskei M., Mos M., Mullins J., Nelson D.R., Nielsen J., Oakley B.R., Osmani S.A., Pakula T., Paszewski A., Paulsen I., Pilsyk S., Pocsi I., Punt P.J., Ram A.F., Ren Q., Robellet X., Robson G., Seiboth B., van Solingen P., Specht T., Sun J., Taheri-Talesh N., Takeshita N., Ussery D., vanKuyk P.A., Visser H., van de Vondervoort P.J., de Vries R.P., Walton J., Xiang X., Xiong Y., Zeng A.P., Brandt B.W., Cornell M.J., van den Hondel C.A., Visser J., Oliver S.G., Turner G.
Fungal Genet. Biol. 46:S2-13(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X64601 mRNA. Translation: CAA45885.1.
AACD01000064 Genomic DNA. Translation: EAA59250.1.
BN001302 Genomic DNA. Translation: CBF75046.1.
PIRS24395.
RefSeqXP_661545.1. XM_656453.1.

3D structure databases

ProteinModelPortalP30303.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING162425.CADANIAP00004753.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiCADANIAT00004753; CADANIAP00004753; CADANIAG00004753.
GeneID2873361.
KEGGani:AN3941.2.

Phylogenomic databases

eggNOGCOG5105.
HOGENOMHOG000215320.
KOK02555.
OMAQRTCERE.
OrthoDBEOG7VMPGR.

Family and domain databases

Gene3D3.40.250.10. 1 hit.
InterProIPR000751. MPI_Phosphatase.
IPR001763. Rhodanese-like_dom.
[Graphical view]
PfamPF00581. Rhodanese. 1 hit.
[Graphical view]
PRINTSPR00716. MPIPHPHTASE.
SMARTSM00450. RHOD. 1 hit.
[Graphical view]
SUPFAMSSF52821. SSF52821. 1 hit.
PROSITEPS50206. RHODANESE_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMPIP_EMENI
AccessionPrimary (citable) accession number: P30303
Secondary accession number(s): C8V635, Q5B689
Entry history
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: May 1, 2007
Last modified: April 16, 2014
This is version 87 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families