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Protein

M-phase inducer phosphatase

Gene

nimT

Organism
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

This protein functions as a dosage-dependent inducer in mitotic control. It is a tyrosine protein phosphatase required for progression of the cell cycle. It may directly dephosphorylate p34(cdc2) and activate the p34(cdc2) kinase activity.

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei421By similarity1

GO - Molecular functioni

  • protein tyrosine phosphatase activity Source: AspGD

GO - Biological processi

  • cell division Source: UniProtKB-KW
  • G2/M transition of mitotic cell cycle Source: AspGD
  • positive regulation of cell cycle G2/M phase transition Source: InterPro
  • positive regulation of mitotic nuclear division Source: AspGD
  • regulation of cyclin-dependent protein serine/threonine kinase activity Source: AspGD

Keywordsi

Molecular functionHydrolase, Protein phosphatase
Biological processCell cycle, Cell division, Mitosis

Names & Taxonomyi

Protein namesi
Recommended name:
M-phase inducer phosphatase (EC:3.1.3.48)
Gene namesi
Name:nimT
ORF Names:AN3941
OrganismiEmericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Taxonomic identifieri227321 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
Proteomesi
  • UP000000560 Componenti: Chromosome II
  • UP000005890 Componenti: Unassembled WGS sequence

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001986601 – 556M-phase inducer phosphataseAdd BLAST556

Interactioni

Protein-protein interaction databases

STRINGi162425.CADANIAP00004753.

Structurei

3D structure databases

ProteinModelPortaliP30303.
SMRiP30303.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini371 – 474RhodanesePROSITE-ProRule annotationAdd BLAST104

Sequence similaritiesi

Belongs to the MPI phosphatase family.Curated

Phylogenomic databases

HOGENOMiHOG000215320.
InParanoidiP30303.
KOiK02555.
OMAiQRTCERE.
OrthoDBiEOG092C2GWG.

Family and domain databases

CDDicd01530. Cdc25. 1 hit.
Gene3Di3.40.250.10. 1 hit.
InterProiView protein in InterPro
IPR000751. MPI_Phosphatase.
IPR001763. Rhodanese-like_dom.
IPR036873. Rhodanese-like_dom_sf.
PfamiView protein in Pfam
PF00581. Rhodanese. 1 hit.
PRINTSiPR00716. MPIPHPHTASE.
SMARTiView protein in SMART
SM00450. RHOD. 1 hit.
SUPFAMiSSF52821. SSF52821. 1 hit.
PROSITEiView protein in PROSITE
PS50206. RHODANESE_3. 1 hit.

Sequencei

Sequence statusi: Complete.

P30303-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEHSSPLAAM QPPSVMLGHC FRSDAPTSYH GFSPLPGLGP GGFNFKDLSM
60 70 80 90 100
KRSNGDYFGT KVVRGSSPTA SLAADLSQNF HIDQSPQVAT PRRSLFSACL
110 120 130 140 150
LGNGNRRGVD DAMTTPPLPS SSPAPAMDIM DMSPLPHKPP FISTPEIELD
160 170 180 190 200
SPTLESSPMD TTMMSTDGLV PDSPTVLPKD GKQERRRPTF LRPSLARSKA
210 220 230 240 250
QSFQVGMTRP APESQGPPFK FQTNGINKTS SGVAASLEDM FGESPQRERP
260 270 280 290 300
MMRINSTSGL NSRLRPPLGS GSHVRGNGSP SAASVRKSAH PNMRPRKQCR
310 320 330 340 350
RSLSMYEHPE DVIADSEVSY TSNAPLQSIS DFEETQALQL PHFIPEEQAD
360 370 380 390 400
NLPRIDKATL VDIKEGKYDN MFDNIMIIDC RFEYEYDGGH IVGAVNYNDK
410 420 430 440 450
ENLAAELFAD PKPRTAIVFH CEYSVHRAPL MAKYIRHRDR AYNVDHYPQL
460 470 480 490 500
SYPDMYILEG GYSGFFAEHR SLCYPQNYVE MSAKEHEFAC ERGLGKVKQR
510 520 530 540 550
SKLSRAQTFA FGQQSPEMED SPTGRCRNNP GDRKLLASPF NDSPGSRFPG

RRMLSY
Length:556
Mass (Da):61,626
Last modified:May 1, 2007 - v2
Checksum:iF558E77944A0BA59
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti353P → G in CAA45885 (PubMed:1534750).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X64601 mRNA. Translation: CAA45885.1.
AACD01000064 Genomic DNA. Translation: EAA59250.1.
BN001302 Genomic DNA. Translation: CBF75046.1.
PIRiS24395.
RefSeqiXP_661545.1. XM_656453.1.

Genome annotation databases

EnsemblFungiiCADANIAT00004753; CADANIAP00004753; CADANIAG00004753.
GeneIDi2873361.
KEGGiani:AN3941.2.

Similar proteinsi

Entry informationi

Entry nameiMPIP_EMENI
AccessioniPrimary (citable) accession number: P30303
Secondary accession number(s): C8V635, Q5B689
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: May 1, 2007
Last modified: November 22, 2017
This is version 108 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families