##gff-version 3
P30301	UniProtKB	Chain	1	263	.	.	.	ID=PRO_0000063912;Note=Lens fiber major intrinsic protein	
P30301	UniProtKB	Topological domain	1	8	.	.	.	Note=Cytoplasmic;Ontology_term=ECO:0000250;evidence=ECO:0000250	
P30301	UniProtKB	Transmembrane	9	32	.	.	.	Note=Helical;Ontology_term=ECO:0000250;evidence=ECO:0000250	
P30301	UniProtKB	Topological domain	33	38	.	.	.	Note=Extracellular;Ontology_term=ECO:0000250;evidence=ECO:0000250	
P30301	UniProtKB	Transmembrane	39	61	.	.	.	Note=Helical;Ontology_term=ECO:0000250;evidence=ECO:0000250	
P30301	UniProtKB	Intramembrane	62	67	.	.	.	Ontology_term=ECO:0000250;evidence=ECO:0000250	
P30301	UniProtKB	Intramembrane	68	78	.	.	.	Note=Helical;Ontology_term=ECO:0000250;evidence=ECO:0000250	
P30301	UniProtKB	Topological domain	79	84	.	.	.	Note=Cytoplasmic;Ontology_term=ECO:0000250;evidence=ECO:0000250	
P30301	UniProtKB	Transmembrane	85	107	.	.	.	Note=Helical;Ontology_term=ECO:0000250;evidence=ECO:0000250	
P30301	UniProtKB	Topological domain	108	126	.	.	.	Note=Extracellular;Ontology_term=ECO:0000250;evidence=ECO:0000250	
P30301	UniProtKB	Transmembrane	127	147	.	.	.	Note=Helical;Ontology_term=ECO:0000250;evidence=ECO:0000250	
P30301	UniProtKB	Topological domain	148	159	.	.	.	Note=Cytoplasmic;Ontology_term=ECO:0000250;evidence=ECO:0000250	
P30301	UniProtKB	Transmembrane	160	176	.	.	.	Note=Helical;Ontology_term=ECO:0000250;evidence=ECO:0000250	
P30301	UniProtKB	Intramembrane	177	183	.	.	.	Ontology_term=ECO:0000250;evidence=ECO:0000250	
P30301	UniProtKB	Intramembrane	184	194	.	.	.	Note=Helical;Ontology_term=ECO:0000250;evidence=ECO:0000250	
P30301	UniProtKB	Topological domain	195	200	.	.	.	Note=Extracellular;Ontology_term=ECO:0000250;evidence=ECO:0000250	
P30301	UniProtKB	Transmembrane	201	219	.	.	.	Note=Helical;Ontology_term=ECO:0000250;evidence=ECO:0000250	
P30301	UniProtKB	Topological domain	220	263	.	.	.	Note=Cytoplasmic;Ontology_term=ECO:0000250;evidence=ECO:0000250	
P30301	UniProtKB	Region	227	237	.	.	.	Note=Interaction with CALM;Ontology_term=ECO:0000250;evidence=ECO:0000250	
P30301	UniProtKB	Motif	68	70	.	.	.	Note=NPA 1	
P30301	UniProtKB	Motif	184	186	.	.	.	Note=NPA 2	
P30301	UniProtKB	Site	149	149	.	.	.	Note=Important for water channel gating;Ontology_term=ECO:0000250;evidence=ECO:0000250	
P30301	UniProtKB	Site	246	246	.	.	.	Note=Interaction with BFSP1;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P06624	
P30301	UniProtKB	Site	250	250	.	.	.	Note=Interaction with BFSP1;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P06624	
P30301	UniProtKB	Modified residue	235	235	.	.	.	Note=Phosphoserine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10634618;Dbxref=PMID:10634618	
P30301	UniProtKB	Modified residue	245	245	.	.	.	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P06624	
P30301	UniProtKB	Modified residue	246	246	.	.	.	Note=Deamidated asparagine%3B by deterioration;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10634618;Dbxref=PMID:10634618	
P30301	UniProtKB	Modified residue	259	259	.	.	.	Note=Deamidated asparagine%3B by deterioration;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10634618;Dbxref=PMID:10634618	
P30301	UniProtKB	Natural variant	33	33	.	.	.	ID=VAR_071601;Note=In CTRCT15%3B reduces cell-to-cell adhesion%2C reduces cell-to-cell gap junction coupling%2C no loss of cell membrane localization%2C no loss of water channel activity. R->C;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:17893667,ECO:0000269|PubMed:24120416;Dbxref=dbSNP:rs864309693,PMID:17893667,PMID:24120416	
P30301	UniProtKB	Natural variant	107	107	.	.	.	ID=VAR_071602;Note=In CTRCT15%3B likely benign. V->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20361015;Dbxref=dbSNP:rs74641138,PMID:20361015	
P30301	UniProtKB	Natural variant	134	134	.	.	.	ID=VAR_011497;Note=In CTRCT15%3B non-progressive lamellar cataract%3B loss of activity. E->G;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10802646,ECO:0000269|PubMed:11001937;Dbxref=dbSNP:rs121917869,PMID:10802646,PMID:11001937	
P30301	UniProtKB	Natural variant	138	138	.	.	.	ID=VAR_011498;Note=In CTRCT15%3B progressive polymorphic and lamellar cataract%3B loss of activity. T->R;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10802646,ECO:0000269|PubMed:11001937;Dbxref=dbSNP:rs121917867,PMID:10802646,PMID:11001937	
P30301	UniProtKB	Natural variant	150	150	.	.	.	ID=VAR_075528;Note=In CTRCT15%3B loss of plasma membrane expression. D->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25946197;Dbxref=dbSNP:rs778327521,PMID:25946197	
P30301	UniProtKB	Natural variant	165	165	.	.	.	ID=VAR_075529;Note=In CTRCT15%3B uncertain significance%3B loss of plasma membrane expression. G->D;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:23116563,ECO:0000269|PubMed:29914532;Dbxref=PMID:23116563,PMID:29914532	
P30301	UniProtKB	Natural variant	177	177	.	.	.	ID=VAR_084819;Note=In CTRCT15%3B uncertain significance. Y->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29914532;Dbxref=PMID:29914532	
P30301	UniProtKB	Natural variant	187	187	.	.	.	ID=VAR_071603;Note=In CTRCT15. R->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21245956;Dbxref=dbSNP:rs267603585,PMID:21245956	
P30301	UniProtKB	Natural variant	204	263	.	.	.	ID=VAR_084820;Note=In CTRCT15%3B uncertain significance. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29914532;Dbxref=PMID:29914532	
P30301	UniProtKB	Natural variant	211	263	.	.	.	ID=VAR_084821;Note=In CTRCT15%3B uncertain significance. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28839118;Dbxref=PMID:28839118	
P30301	UniProtKB	Natural variant	233	233	.	.	.	ID=VAR_071604;Note=In CTRCT15. R->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17960133;Dbxref=dbSNP:rs1555179699,PMID:17960133