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Protein

S-phase entry cyclin-5

Gene

CLB5

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for efficient progression through S phase and possibly for the normal progression through meiosis. Interacts with CDC28.

Miscellaneous

Present with 521 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

  • cyclin-dependent protein serine/threonine kinase regulator activity Source: SGD

GO - Biological processi

  • cell division Source: UniProtKB-KW
  • G1/S transition of mitotic cell cycle Source: SGD
  • G2/M transition of mitotic cell cycle Source: SGD
  • positive regulation of DNA replication Source: SGD
  • positive regulation of spindle pole body separation Source: SGD
  • premeiotic DNA replication Source: SGD
  • regulation of cyclin-dependent protein serine/threonine kinase activity Source: SGD
  • regulation of mitotic spindle assembly Source: SGD

Keywordsi

Molecular functionCyclin
Biological processCell cycle, Cell division

Enzyme and pathway databases

BioCyciYEAST:G3O-34259-MONOMER
ReactomeiR-SCE-176408 Regulation of APC/C activators between G1/S and early anaphase
R-SCE-2299718 Condensation of Prophase Chromosomes
R-SCE-2980767 Activation of NIMA Kinases NEK9, NEK6, NEK7
R-SCE-3214858 RMTs methylate histone arginines
R-SCE-4419969 Depolymerisation of the Nuclear Lamina
R-SCE-5687128 MAPK6/MAPK4 signaling
R-SCE-5689880 Ub-specific processing proteases
R-SCE-6804114 TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest
R-SCE-68949 Orc1 removal from chromatin
R-SCE-69202 Cyclin E associated events during G1/S transition
R-SCE-69229 Ubiquitin-dependent degradation of Cyclin D1
R-SCE-69231 Cyclin D associated events in G1
R-SCE-69273 Cyclin A/B1/B2 associated events during G2/M transition
R-SCE-69478 G2/M DNA replication checkpoint
R-SCE-69656 Cyclin A:Cdk2-associated events at S phase entry
R-SCE-75035 Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex

Names & Taxonomyi

Protein namesi
Recommended name:
S-phase entry cyclin-5
Gene namesi
Name:CLB5
Ordered Locus Names:YPR120C
ORF Names:P9642.8
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XVI

Organism-specific databases

EuPathDBiFungiDB:YPR120C
SGDiS000006324 CLB5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000804081 – 435S-phase entry cyclin-5Add BLAST435

Proteomic databases

PaxDbiP30283
PRIDEiP30283

PTM databases

iPTMnetiP30283

Expressioni

Developmental stagei

Maximally expressed just before cell cycle start.

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi36288, 313 interactors
DIPiDIP-2710N
ELMiP30283
IntActiP30283, 30 interactors
MINTiP30283
STRINGi4932.YPR120C

Structurei

3D structure databases

ProteinModelPortaliP30283
SMRiP30283
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cyclin family. Cyclin AB subfamily.Curated

Phylogenomic databases

GeneTreeiENSGT00760000118939
HOGENOMiHOG000000929
InParanoidiP30283
KOiK06651
OMAiIRLKYKQ
OrthoDBiEOG092C2S0G

Family and domain databases

CDDicd00043 CYCLIN, 2 hits
InterProiView protein in InterPro
IPR013763 Cyclin-like
IPR036915 Cyclin-like_sf
IPR004367 Cyclin_C-dom
IPR006671 Cyclin_N
PfamiView protein in Pfam
PF02984 Cyclin_C, 1 hit
PF00134 Cyclin_N, 1 hit
SMARTiView protein in SMART
SM00385 CYCLIN, 2 hits
SM01332 Cyclin_C, 1 hit
SUPFAMiSSF47954 SSF47954, 2 hits
PROSITEiView protein in PROSITE
PS00292 CYCLINS, 1 hit

Sequencei

Sequence statusi: Complete.

P30283-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGENHDHEQS IKRNSMIYNE NERQLCNSNL KILQNKRALS KNDSSSKQQV
60 70 80 90 100
QDSKPRRALT DVPVNNNPLS QNKRIVAGSK AAKVRREENI RPIVSAVQKR
110 120 130 140 150
QIYNDRTAAE QEEEEEEEGE DDDAASIVNK KRRIDAEGVS EIVGWQDLDY
160 170 180 190 200
VEKDDTAMVA EYSAEIFAFL YRRELETLPS HNYLLDKTSK YYLRPSMRTI
210 220 230 240 250
LVDWLVEVHE KFQCYPETLF LSINLMDRFL AKNKVTMNKL QLLAVTSLFI
260 270 280 290 300
AAKFEEVNLP KLAEYAYITD GAASKNDIKN AEMFMLTSLE FNIGWPNPLN
310 320 330 340 350
FLRRISKADD YDPVNRNIGK FILEYAYCCH QFIHLPPSTV SAMAMYIARR
360 370 380 390 400
MTNRNKNELW NGTLQHYSGG IDPIHDEAFQ SLCIDLVKDI ASSKTHLDSL
410 420 430
ILKYKKPRYG SVYFQTFKWC TSEMHSNFQN LFNLK
Length:435
Mass (Da):50,431
Last modified:April 1, 1993 - v1
Checksum:i5AD67EB841BA5759
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M91209 Genomic DNA Translation: AAA34503.1
X70435 Genomic DNA Translation: CAA49893.1
U40828 Genomic DNA Translation: AAB68061.1
BK006949 Genomic DNA Translation: DAA11535.1
PIRiS31290
RefSeqiNP_015445.1, NM_001184217.1

Genome annotation databases

EnsemblFungiiYPR120C; YPR120C; YPR120C
GeneIDi856237
KEGGisce:YPR120C

Similar proteinsi

Entry informationi

Entry nameiCGS5_YEAST
AccessioniPrimary (citable) accession number: P30283
Secondary accession number(s): D6W4B9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: March 28, 2018
This is version 155 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health