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Protein

S-phase entry cyclin-5

Gene

CLB5

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Required for efficient progression through S phase and possibly for the normal progression through meiosis. Interacts with CDC28.

GO - Molecular functioni

  1. cyclin-dependent protein serine/threonine kinase regulator activity Source: SGD

GO - Biological processi

  1. cell division Source: UniProtKB-KW
  2. G1/S transition of mitotic cell cycle Source: SGD
  3. G2/M transition of mitotic cell cycle Source: SGD
  4. positive regulation of DNA replication Source: SGD
  5. positive regulation of spindle pole body separation Source: SGD
  6. premeiotic DNA replication Source: SGD
  7. regulation of cyclin-dependent protein serine/threonine kinase activity Source: SGD
  8. spindle assembly Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Cyclin

Keywords - Biological processi

Cell cycle, Cell division

Enzyme and pathway databases

BioCyciYEAST:G3O-34259-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
S-phase entry cyclin-5
Gene namesi
Name:CLB5
Ordered Locus Names:YPR120C
ORF Names:P9642.8
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome XVI

Organism-specific databases

CYGDiYPR120c.
SGDiS000006324. CLB5.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: SGD
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 435435S-phase entry cyclin-5PRO_0000080408Add
BLAST

Proteomic databases

PaxDbiP30283.
PeptideAtlasiP30283.

Expressioni

Developmental stagei

Maximally expressed just before cell cycle start.

Gene expression databases

GenevestigatoriP30283.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CDC28P005463EBI-4538,EBI-4253

Protein-protein interaction databases

BioGridi36288. 204 interactions.
DIPiDIP-2710N.
IntActiP30283. 24 interactions.
MINTiMINT-481362.
STRINGi4932.YPR120C.

Structurei

3D structure databases

ProteinModelPortaliP30283.
SMRiP30283. Positions 159-412.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cyclin family. Cyclin AB subfamily.Curated

Phylogenomic databases

eggNOGiCOG5024.
GeneTreeiENSGT00760000118939.
HOGENOMiHOG000000929.
InParanoidiP30283.
KOiK06651.
OMAiLSINLMD.
OrthoDBiEOG7FNCJX.

Family and domain databases

Gene3Di1.10.472.10. 2 hits.
InterProiIPR013763. Cyclin-like.
IPR014400. Cyclin_A/B/D/E/F.
IPR004367. Cyclin_C-dom.
IPR006671. Cyclin_N.
[Graphical view]
PfamiPF02984. Cyclin_C. 1 hit.
PF00134. Cyclin_N. 1 hit.
[Graphical view]
PIRSFiPIRSF001771. Cyclin_A_B_D_E. 1 hit.
SMARTiSM00385. CYCLIN. 2 hits.
[Graphical view]
SUPFAMiSSF47954. SSF47954. 2 hits.
PROSITEiPS00292. CYCLINS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P30283-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGENHDHEQS IKRNSMIYNE NERQLCNSNL KILQNKRALS KNDSSSKQQV
60 70 80 90 100
QDSKPRRALT DVPVNNNPLS QNKRIVAGSK AAKVRREENI RPIVSAVQKR
110 120 130 140 150
QIYNDRTAAE QEEEEEEEGE DDDAASIVNK KRRIDAEGVS EIVGWQDLDY
160 170 180 190 200
VEKDDTAMVA EYSAEIFAFL YRRELETLPS HNYLLDKTSK YYLRPSMRTI
210 220 230 240 250
LVDWLVEVHE KFQCYPETLF LSINLMDRFL AKNKVTMNKL QLLAVTSLFI
260 270 280 290 300
AAKFEEVNLP KLAEYAYITD GAASKNDIKN AEMFMLTSLE FNIGWPNPLN
310 320 330 340 350
FLRRISKADD YDPVNRNIGK FILEYAYCCH QFIHLPPSTV SAMAMYIARR
360 370 380 390 400
MTNRNKNELW NGTLQHYSGG IDPIHDEAFQ SLCIDLVKDI ASSKTHLDSL
410 420 430
ILKYKKPRYG SVYFQTFKWC TSEMHSNFQN LFNLK
Length:435
Mass (Da):50,431
Last modified:April 1, 1993 - v1
Checksum:i5AD67EB841BA5759
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M91209 Genomic DNA. Translation: AAA34503.1.
X70435 Genomic DNA. Translation: CAA49893.1.
U40828 Genomic DNA. Translation: AAB68061.1.
BK006949 Genomic DNA. Translation: DAA11535.1.
PIRiS31290.
RefSeqiNP_015445.1. NM_001184217.1.

Genome annotation databases

EnsemblFungiiYPR120C; YPR120C; YPR120C.
GeneIDi856237.
KEGGisce:YPR120C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M91209 Genomic DNA. Translation: AAA34503.1.
X70435 Genomic DNA. Translation: CAA49893.1.
U40828 Genomic DNA. Translation: AAB68061.1.
BK006949 Genomic DNA. Translation: DAA11535.1.
PIRiS31290.
RefSeqiNP_015445.1. NM_001184217.1.

3D structure databases

ProteinModelPortaliP30283.
SMRiP30283. Positions 159-412.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi36288. 204 interactions.
DIPiDIP-2710N.
IntActiP30283. 24 interactions.
MINTiMINT-481362.
STRINGi4932.YPR120C.

Proteomic databases

PaxDbiP30283.
PeptideAtlasiP30283.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYPR120C; YPR120C; YPR120C.
GeneIDi856237.
KEGGisce:YPR120C.

Organism-specific databases

CYGDiYPR120c.
SGDiS000006324. CLB5.

Phylogenomic databases

eggNOGiCOG5024.
GeneTreeiENSGT00760000118939.
HOGENOMiHOG000000929.
InParanoidiP30283.
KOiK06651.
OMAiLSINLMD.
OrthoDBiEOG7FNCJX.

Enzyme and pathway databases

BioCyciYEAST:G3O-34259-MONOMER.

Miscellaneous databases

NextBioi981496.

Gene expression databases

GenevestigatoriP30283.

Family and domain databases

Gene3Di1.10.472.10. 2 hits.
InterProiIPR013763. Cyclin-like.
IPR014400. Cyclin_A/B/D/E/F.
IPR004367. Cyclin_C-dom.
IPR006671. Cyclin_N.
[Graphical view]
PfamiPF02984. Cyclin_C. 1 hit.
PF00134. Cyclin_N. 1 hit.
[Graphical view]
PIRSFiPIRSF001771. Cyclin_A_B_D_E. 1 hit.
SMARTiSM00385. CYCLIN. 2 hits.
[Graphical view]
SUPFAMiSSF47954. SSF47954. 2 hits.
PROSITEiPS00292. CYCLINS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "CLB5: a novel B cyclin from budding yeast with a role in S phase."
    Epstein C.B., Cross F.R.
    Genes Dev. 6:1695-1706(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: BF264-15D.
  2. "CLB5 and CLB6, a new pair of B cyclins involved in DNA replication in Saccharomyces cerevisiae."
    Schwob E., Nasmyth K.
    Genes Dev. 7:1160-1175(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204510 / AB320.
  3. "A new pair of B-type cyclins from Saccharomyces cerevisiae that function early in the cell cycle."
    Kuehne C., Linder P.
    EMBO J. 12:3437-3447(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  4. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI."
    Bussey H., Storms R.K., Ahmed A., Albermann K., Allen E., Ansorge W., Araujo R., Aparicio A., Barrell B.G., Badcock K., Benes V., Botstein D., Bowman S., Brueckner M., Carpenter J., Cherry J.M., Chung E., Churcher C.M.
    , Coster F., Davis K., Davis R.W., Dietrich F.S., Delius H., DiPaolo T., Dubois E., Duesterhoeft A., Duncan M., Floeth M., Fortin N., Friesen J.D., Fritz C., Goffeau A., Hall J., Hebling U., Heumann K., Hilbert H., Hillier L.W., Hunicke-Smith S., Hyman R.W., Johnston M., Kalman S., Kleine K., Komp C., Kurdi O., Lashkari D., Lew H., Lin A., Lin D., Louis E.J., Marathe R., Messenguy F., Mewes H.-W., Mirtipati S., Moestl D., Mueller-Auer S., Namath A., Nentwich U., Oefner P., Pearson D., Petel F.X., Pohl T.M., Purnelle B., Rajandream M.A., Rechmann S., Rieger M., Riles L., Roberts D., Schaefer M., Scharfe M., Scherens B., Schramm S., Schroeder M., Sdicu A.-M., Tettelin H., Urrestarazu L.A., Ushinsky S., Vierendeels F., Vissers S., Voss H., Walsh S.V., Wambutt R., Wang Y., Wedler E., Wedler H., Winnett E., Zhong W.-W., Zollner A., Vo D.H., Hani J.
    Nature 387:103-105(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  5. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  6. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  7. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
    Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
    Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiCGS5_YEAST
AccessioniPrimary (citable) accession number: P30283
Secondary accession number(s): D6W4B9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: January 7, 2015
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 521 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XVI
    Yeast (Saccharomyces cerevisiae) chromosome XVI: entries and gene names

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.