S-phase entry cyclin-5 - Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

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P30283 (CGS5_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified May 29, 2013. Version 108. History...

Clusters with 100%, 90%, 50% identity |

Documents (3) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
S-phase entry cyclin-5

Gene names

Name:	CLB5
Ordered Locus Names:	YPR120C
ORF Names:	P9642.8

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]

Taxonomic identifier

559292 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces ›

Protein attributes

Sequence length	435 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Required for efficient progression through S phase and possibly for the normal progression through meiosis. Interacts with CDC28.
Developmental stage	Maximally expressed just before cell cycle start.
Miscellaneous	Present with 521 molecules/cell in log phase SD medium.
Sequence similarities	Belongs to the cyclin family. Cyclin AB subfamily.

Ontologies

Keywords
Biological process	Cell cycle Cell division
Molecular function	Cyclin
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	G1/S transition of mitotic cell cycle Inferred from expression pattern Ref.2. Source: SGD G2/M transition of mitotic cell cycle Inferred from expression pattern Ref.2. Source: SGD cell division Inferred from electronic annotation. Source: UniProtKB-KW positive regulation of DNA replication Inferred from mutant phenotype Ref.2. Source: SGD positive regulation of spindle pole body separation Inferred from genetic interaction PubMed 11438663 PubMed 16688214. Source: SGD premeiotic DNA replication Inferred from mutant phenotype PubMed 9732268. Source: SGD regulation of S phase of mitotic cell cycle Inferred from mutant phenotype Ref.2. Source: SGD regulation of cyclin-dependent protein serine/threonine kinase activity Inferred from direct assay PubMed 7954792. Source: SGD spindle assembly Inferred from mutant phenotype Ref.2. Source: SGD
Cellular_component	nucleus Inferred from direct assay PubMed 10848575. Source: SGD
Molecular_function	cyclin-dependent protein serine/threonine kinase regulator activity Inferred from direct assay PubMed 7954792. Source: SGD
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
CDC28	P00546	3	EBI-4538,EBI-4253

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 435

435

S-phase entry cyclin-5

PRO_0000080408

Amino acid modifications

Modified residue

Phosphoserine Ref.7

Modified residue

107

Phosphothreonine Ref.7

Sequences

Sequence

Length

Mass (Da)

Tools

P30283 [UniParc].

Last modified April 1, 1993. Version 1.
Checksum: 5AD67EB841BA5759
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FASTA

435

50,431

        10         20         30         40         50         60 
MGENHDHEQS IKRNSMIYNE NERQLCNSNL KILQNKRALS KNDSSSKQQV QDSKPRRALT 

        70         80         90        100        110        120 
DVPVNNNPLS QNKRIVAGSK AAKVRREENI RPIVSAVQKR QIYNDRTAAE QEEEEEEEGE 

       130        140        150        160        170        180 
DDDAASIVNK KRRIDAEGVS EIVGWQDLDY VEKDDTAMVA EYSAEIFAFL YRRELETLPS 

       190        200        210        220        230        240 
HNYLLDKTSK YYLRPSMRTI LVDWLVEVHE KFQCYPETLF LSINLMDRFL AKNKVTMNKL 

       250        260        270        280        290        300 
QLLAVTSLFI AAKFEEVNLP KLAEYAYITD GAASKNDIKN AEMFMLTSLE FNIGWPNPLN 

       310        320        330        340        350        360 
FLRRISKADD YDPVNRNIGK FILEYAYCCH QFIHLPPSTV SAMAMYIARR MTNRNKNELW 

       370        380        390        400        410        420 
NGTLQHYSGG IDPIHDEAFQ SLCIDLVKDI ASSKTHLDSL ILKYKKPRYG SVYFQTFKWC 

       430 
TSEMHSNFQN LFNLK

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"CLB5: a novel B cyclin from budding yeast with a role in S phase." Epstein C.B., Cross F.R. Genes Dev. 6:1695-1706(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: BF264-15D.
[2]	"CLB5 and CLB6, a new pair of B cyclins involved in DNA replication in Saccharomyces cerevisiae." Schwob E., Nasmyth K. Genes Dev. 7:1160-1175(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 204510 / AB320.
[3]	"A new pair of B-type cyclins from Saccharomyces cerevisiae that function early in the cell cycle." Kuehne C., Linder P. EMBO J. 12:3437-3447(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]	"The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI." Bussey H., Storms R.K., Ahmed A., Albermann K., Allen E., Ansorge W., Araujo R., Aparicio A., Barrell B.G., Badcock K., Benes V., Botstein D., Bowman S., Brueckner M., Carpenter J., Cherry J.M., Chung E., Churcher C.M. Hani J. Nature 387:103-105(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204511 / S288c / AB972.
[5]	Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c.
[6]	"Global analysis of protein expression in yeast." Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S. Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract] Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[7]	"A multidimensional chromatography technology for in-depth phosphoproteome analysis." Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H. Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-15 AND THR-107, MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M91209 Genomic DNA. Translation: AAA34503.1. X70435 Genomic DNA. Translation: CAA49893.1. U40828 Genomic DNA. Translation: AAB68061.1. BK006949 Genomic DNA. Translation: DAA11535.1.
PIR	S31290.
RefSeq	NP_015445.1. NM_001184217.1.
3D structure databases
ProteinModelPortal	P30283.
SMR	P30283. Positions 159-412.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-2710N.
IntAct	P30283. 24 interactions.
MINT	MINT-481362.
STRING	4932.YPR120C.
Proteomic databases
PaxDb	P30283.
PeptideAtlas	P30283.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	YPR120C; YPR120C; YPR120C.
GeneID	856237.
KEGG	sce:YPR120C.
Organism-specific databases
CYGD	YPR120c.
SGD	S000006324. CLB5.
Phylogenomic databases
eggNOG	COG5024.
GeneTree	ENSGT00560000076692.
HOGENOM	HOG000000929.
KO	K06651.
OMA	LSINLMD.
OrthoDB	EOG4PG991.
Enzyme and pathway databases
BioCyc	YEAST:G3O-34259-MONOMER.
Gene expression databases
Genevestigator	P30283.
GermOnline	YPR120C. Saccharomyces cerevisiae.
Family and domain databases
Gene3D	1.10.472.10. 2 hits.
InterPro	IPR013763. Cyclin-like. IPR014400. Cyclin_A/B/D/E. IPR004367. Cyclin_C-dom. IPR006671. Cyclin_N. [Graphical view]
Pfam	PF02984. Cyclin_C. 1 hit. PF00134. Cyclin_N. 1 hit. [Graphical view]
PIRSF	PIRSF001771. Cyclin_A_B_D_E. 1 hit.
SMART	SM00385. CYCLIN. 2 hits. [Graphical view]
SUPFAM	SSF47954. Cyclin_like. 2 hits.
PROSITE	PS00292. CYCLINS. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	981496.

Entry information

Entry name

CGS5_YEAST

Accession

Primary (citable) accession number: P30283
Secondary accession number(s): D6W4B9

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 1, 1993
Last sequence update:	April 1, 1993
Last modified:	May 29, 2013
This is version 108 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program

Relevant documents

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

Yeast chromosome XVI

Yeast (Saccharomyces cerevisiae) chromosome XVI: entries and gene names

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Binary interactions

With

Entry

#Exp.

IntAct

Notes

Sequence annotation (Features)

Molecule processing

Amino acid modifications

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents