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P30283

- CGS5_YEAST

UniProt

P30283 - CGS5_YEAST

Protein

S-phase entry cyclin-5

Gene

CLB5

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 122 (01 Oct 2014)
      Sequence version 1 (01 Apr 1993)
      Previous versions | rss
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    Functioni

    Required for efficient progression through S phase and possibly for the normal progression through meiosis. Interacts with CDC28.

    GO - Molecular functioni

    1. cyclin-dependent protein serine/threonine kinase regulator activity Source: SGD
    2. protein binding Source: IntAct

    GO - Biological processi

    1. cell division Source: UniProtKB-KW
    2. G1/S transition of mitotic cell cycle Source: SGD
    3. G2/M transition of mitotic cell cycle Source: SGD
    4. positive regulation of DNA replication Source: SGD
    5. positive regulation of spindle pole body separation Source: SGD
    6. premeiotic DNA replication Source: SGD
    7. regulation of cyclin-dependent protein serine/threonine kinase activity Source: SGD
    8. spindle assembly Source: SGD

    Keywords - Molecular functioni

    Cyclin

    Keywords - Biological processi

    Cell cycle, Cell division

    Enzyme and pathway databases

    BioCyciYEAST:G3O-34259-MONOMER.
    ReactomeiREACT_188466. Regulation of APC/C activators between G1/S and early anaphase.
    REACT_188487. Cyclin A/B1 associated events during G2/M transition.
    REACT_188488. G2/M DNA replication checkpoint.
    REACT_188908. Condensation of Prometaphase Chromosomes.
    REACT_188916. MASTL Facilitates Mitotic Progression.
    REACT_205363. Cyclin B2 mediated events.
    REACT_211772. E2F-enabled inhibition of pre-replication complex formation.
    REACT_224510. Depolymerisation of the Nuclear Lamina.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    S-phase entry cyclin-5
    Gene namesi
    Name:CLB5
    Ordered Locus Names:YPR120C
    ORF Names:P9642.8
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome XVI

    Organism-specific databases

    CYGDiYPR120c.
    SGDiS000006324. CLB5.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: SGD

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 435435S-phase entry cyclin-5PRO_0000080408Add
    BLAST

    Proteomic databases

    PaxDbiP30283.
    PeptideAtlasiP30283.

    Expressioni

    Developmental stagei

    Maximally expressed just before cell cycle start.

    Gene expression databases

    GenevestigatoriP30283.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    CDC28P005463EBI-4538,EBI-4253

    Protein-protein interaction databases

    BioGridi36288. 203 interactions.
    DIPiDIP-2710N.
    IntActiP30283. 24 interactions.
    MINTiMINT-481362.
    STRINGi4932.YPR120C.

    Structurei

    3D structure databases

    ProteinModelPortaliP30283.
    SMRiP30283. Positions 159-412.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cyclin family. Cyclin AB subfamily.Curated

    Phylogenomic databases

    eggNOGiCOG5024.
    GeneTreeiENSGT00750000117276.
    HOGENOMiHOG000000929.
    KOiK06651.
    OMAiLSINLMD.
    OrthoDBiEOG7FNCJX.

    Family and domain databases

    Gene3Di1.10.472.10. 2 hits.
    InterProiIPR013763. Cyclin-like.
    IPR014400. Cyclin_A/B/D/E/F.
    IPR004367. Cyclin_C-dom.
    IPR006671. Cyclin_N.
    [Graphical view]
    PfamiPF02984. Cyclin_C. 1 hit.
    PF00134. Cyclin_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001771. Cyclin_A_B_D_E. 1 hit.
    SMARTiSM00385. CYCLIN. 2 hits.
    [Graphical view]
    SUPFAMiSSF47954. SSF47954. 2 hits.
    PROSITEiPS00292. CYCLINS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P30283-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGENHDHEQS IKRNSMIYNE NERQLCNSNL KILQNKRALS KNDSSSKQQV    50
    QDSKPRRALT DVPVNNNPLS QNKRIVAGSK AAKVRREENI RPIVSAVQKR 100
    QIYNDRTAAE QEEEEEEEGE DDDAASIVNK KRRIDAEGVS EIVGWQDLDY 150
    VEKDDTAMVA EYSAEIFAFL YRRELETLPS HNYLLDKTSK YYLRPSMRTI 200
    LVDWLVEVHE KFQCYPETLF LSINLMDRFL AKNKVTMNKL QLLAVTSLFI 250
    AAKFEEVNLP KLAEYAYITD GAASKNDIKN AEMFMLTSLE FNIGWPNPLN 300
    FLRRISKADD YDPVNRNIGK FILEYAYCCH QFIHLPPSTV SAMAMYIARR 350
    MTNRNKNELW NGTLQHYSGG IDPIHDEAFQ SLCIDLVKDI ASSKTHLDSL 400
    ILKYKKPRYG SVYFQTFKWC TSEMHSNFQN LFNLK 435
    Length:435
    Mass (Da):50,431
    Last modified:April 1, 1993 - v1
    Checksum:i5AD67EB841BA5759
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M91209 Genomic DNA. Translation: AAA34503.1.
    X70435 Genomic DNA. Translation: CAA49893.1.
    U40828 Genomic DNA. Translation: AAB68061.1.
    BK006949 Genomic DNA. Translation: DAA11535.1.
    PIRiS31290.
    RefSeqiNP_015445.1. NM_001184217.1.

    Genome annotation databases

    EnsemblFungiiYPR120C; YPR120C; YPR120C.
    GeneIDi856237.
    KEGGisce:YPR120C.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M91209 Genomic DNA. Translation: AAA34503.1 .
    X70435 Genomic DNA. Translation: CAA49893.1 .
    U40828 Genomic DNA. Translation: AAB68061.1 .
    BK006949 Genomic DNA. Translation: DAA11535.1 .
    PIRi S31290.
    RefSeqi NP_015445.1. NM_001184217.1.

    3D structure databases

    ProteinModelPortali P30283.
    SMRi P30283. Positions 159-412.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 36288. 203 interactions.
    DIPi DIP-2710N.
    IntActi P30283. 24 interactions.
    MINTi MINT-481362.
    STRINGi 4932.YPR120C.

    Proteomic databases

    PaxDbi P30283.
    PeptideAtlasi P30283.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YPR120C ; YPR120C ; YPR120C .
    GeneIDi 856237.
    KEGGi sce:YPR120C.

    Organism-specific databases

    CYGDi YPR120c.
    SGDi S000006324. CLB5.

    Phylogenomic databases

    eggNOGi COG5024.
    GeneTreei ENSGT00750000117276.
    HOGENOMi HOG000000929.
    KOi K06651.
    OMAi LSINLMD.
    OrthoDBi EOG7FNCJX.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-34259-MONOMER.
    Reactomei REACT_188466. Regulation of APC/C activators between G1/S and early anaphase.
    REACT_188487. Cyclin A/B1 associated events during G2/M transition.
    REACT_188488. G2/M DNA replication checkpoint.
    REACT_188908. Condensation of Prometaphase Chromosomes.
    REACT_188916. MASTL Facilitates Mitotic Progression.
    REACT_205363. Cyclin B2 mediated events.
    REACT_211772. E2F-enabled inhibition of pre-replication complex formation.
    REACT_224510. Depolymerisation of the Nuclear Lamina.

    Miscellaneous databases

    NextBioi 981496.

    Gene expression databases

    Genevestigatori P30283.

    Family and domain databases

    Gene3Di 1.10.472.10. 2 hits.
    InterProi IPR013763. Cyclin-like.
    IPR014400. Cyclin_A/B/D/E/F.
    IPR004367. Cyclin_C-dom.
    IPR006671. Cyclin_N.
    [Graphical view ]
    Pfami PF02984. Cyclin_C. 1 hit.
    PF00134. Cyclin_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001771. Cyclin_A_B_D_E. 1 hit.
    SMARTi SM00385. CYCLIN. 2 hits.
    [Graphical view ]
    SUPFAMi SSF47954. SSF47954. 2 hits.
    PROSITEi PS00292. CYCLINS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "CLB5: a novel B cyclin from budding yeast with a role in S phase."
      Epstein C.B., Cross F.R.
      Genes Dev. 6:1695-1706(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: BF264-15D.
    2. "CLB5 and CLB6, a new pair of B cyclins involved in DNA replication in Saccharomyces cerevisiae."
      Schwob E., Nasmyth K.
      Genes Dev. 7:1160-1175(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 204510 / AB320.
    3. "A new pair of B-type cyclins from Saccharomyces cerevisiae that function early in the cell cycle."
      Kuehne C., Linder P.
      EMBO J. 12:3437-3447(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    4. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI."
      Bussey H., Storms R.K., Ahmed A., Albermann K., Allen E., Ansorge W., Araujo R., Aparicio A., Barrell B.G., Badcock K., Benes V., Botstein D., Bowman S., Brueckner M., Carpenter J., Cherry J.M., Chung E., Churcher C.M.
      , Coster F., Davis K., Davis R.W., Dietrich F.S., Delius H., DiPaolo T., Dubois E., Duesterhoeft A., Duncan M., Floeth M., Fortin N., Friesen J.D., Fritz C., Goffeau A., Hall J., Hebling U., Heumann K., Hilbert H., Hillier L.W., Hunicke-Smith S., Hyman R.W., Johnston M., Kalman S., Kleine K., Komp C., Kurdi O., Lashkari D., Lew H., Lin A., Lin D., Louis E.J., Marathe R., Messenguy F., Mewes H.-W., Mirtipati S., Moestl D., Mueller-Auer S., Namath A., Nentwich U., Oefner P., Pearson D., Petel F.X., Pohl T.M., Purnelle B., Rajandream M.A., Rechmann S., Rieger M., Riles L., Roberts D., Schaefer M., Scharfe M., Scherens B., Schramm S., Schroeder M., Sdicu A.-M., Tettelin H., Urrestarazu L.A., Ushinsky S., Vierendeels F., Vissers S., Voss H., Walsh S.V., Wambutt R., Wang Y., Wedler E., Wedler H., Winnett E., Zhong W.-W., Zollner A., Vo D.H., Hani J.
      Nature 387:103-105(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    5. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    6. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
    7. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
      Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
      Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiCGS5_YEAST
    AccessioniPrimary (citable) accession number: P30283
    Secondary accession number(s): D6W4B9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 1, 1993
    Last sequence update: April 1, 1993
    Last modified: October 1, 2014
    This is version 122 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 521 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome XVI
      Yeast (Saccharomyces cerevisiae) chromosome XVI: entries and gene names

    External Data

    Dasty 3