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P30283

- CGS5_YEAST

UniProt

P30283 - CGS5_YEAST

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Protein

S-phase entry cyclin-5

Gene
CLB5, YPR120C, P9642.8
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Required for efficient progression through S phase and possibly for the normal progression through meiosis. Interacts with CDC28.

GO - Molecular functioni

  1. cyclin-dependent protein serine/threonine kinase regulator activity Source: SGD
  2. protein binding Source: IntAct

GO - Biological processi

  1. cell division Source: UniProtKB-KW
  2. G1/S transition of mitotic cell cycle Source: SGD
  3. G2/M transition of mitotic cell cycle Source: SGD
  4. positive regulation of DNA replication Source: SGD
  5. positive regulation of spindle pole body separation Source: SGD
  6. premeiotic DNA replication Source: SGD
  7. regulation of cyclin-dependent protein serine/threonine kinase activity Source: SGD
  8. spindle assembly Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Cyclin

Keywords - Biological processi

Cell cycle, Cell division

Enzyme and pathway databases

BioCyciYEAST:G3O-34259-MONOMER.
ReactomeiREACT_188466. Regulation of APC/C activators between G1/S and early anaphase.
REACT_188487. Cyclin A/B1 associated events during G2/M transition.
REACT_188488. G2/M DNA replication checkpoint.
REACT_188908. Condensation of Prometaphase Chromosomes.
REACT_188916. MASTL Facilitates Mitotic Progression.
REACT_205363. Cyclin B2 mediated events.
REACT_211772. E2F-enabled inhibition of pre-replication complex formation.
REACT_224510. Depolymerisation of the Nuclear Lamina.

Names & Taxonomyi

Protein namesi
Recommended name:
S-phase entry cyclin-5
Gene namesi
Name:CLB5
Ordered Locus Names:YPR120C
ORF Names:P9642.8
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome XVI

Organism-specific databases

CYGDiYPR120c.
SGDiS000006324. CLB5.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: SGD
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 435435S-phase entry cyclin-5PRO_0000080408Add
BLAST

Proteomic databases

PaxDbiP30283.
PeptideAtlasiP30283.

Expressioni

Developmental stagei

Maximally expressed just before cell cycle start.

Gene expression databases

GenevestigatoriP30283.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CDC28P005463EBI-4538,EBI-4253

Protein-protein interaction databases

BioGridi36288. 203 interactions.
DIPiDIP-2710N.
IntActiP30283. 24 interactions.
MINTiMINT-481362.
STRINGi4932.YPR120C.

Structurei

3D structure databases

ProteinModelPortaliP30283.
SMRiP30283. Positions 159-412.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG5024.
GeneTreeiENSGT00750000117276.
HOGENOMiHOG000000929.
KOiK06651.
OMAiLSINLMD.
OrthoDBiEOG7FNCJX.

Family and domain databases

Gene3Di1.10.472.10. 2 hits.
InterProiIPR013763. Cyclin-like.
IPR014400. Cyclin_A/B/D/E/F.
IPR004367. Cyclin_C-dom.
IPR006671. Cyclin_N.
[Graphical view]
PfamiPF02984. Cyclin_C. 1 hit.
PF00134. Cyclin_N. 1 hit.
[Graphical view]
PIRSFiPIRSF001771. Cyclin_A_B_D_E. 1 hit.
SMARTiSM00385. CYCLIN. 2 hits.
[Graphical view]
SUPFAMiSSF47954. SSF47954. 2 hits.
PROSITEiPS00292. CYCLINS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P30283-1 [UniParc]FASTAAdd to Basket

« Hide

MGENHDHEQS IKRNSMIYNE NERQLCNSNL KILQNKRALS KNDSSSKQQV    50
QDSKPRRALT DVPVNNNPLS QNKRIVAGSK AAKVRREENI RPIVSAVQKR 100
QIYNDRTAAE QEEEEEEEGE DDDAASIVNK KRRIDAEGVS EIVGWQDLDY 150
VEKDDTAMVA EYSAEIFAFL YRRELETLPS HNYLLDKTSK YYLRPSMRTI 200
LVDWLVEVHE KFQCYPETLF LSINLMDRFL AKNKVTMNKL QLLAVTSLFI 250
AAKFEEVNLP KLAEYAYITD GAASKNDIKN AEMFMLTSLE FNIGWPNPLN 300
FLRRISKADD YDPVNRNIGK FILEYAYCCH QFIHLPPSTV SAMAMYIARR 350
MTNRNKNELW NGTLQHYSGG IDPIHDEAFQ SLCIDLVKDI ASSKTHLDSL 400
ILKYKKPRYG SVYFQTFKWC TSEMHSNFQN LFNLK 435
Length:435
Mass (Da):50,431
Last modified:April 1, 1993 - v1
Checksum:i5AD67EB841BA5759
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M91209 Genomic DNA. Translation: AAA34503.1.
X70435 Genomic DNA. Translation: CAA49893.1.
U40828 Genomic DNA. Translation: AAB68061.1.
BK006949 Genomic DNA. Translation: DAA11535.1.
PIRiS31290.
RefSeqiNP_015445.1. NM_001184217.1.

Genome annotation databases

EnsemblFungiiYPR120C; YPR120C; YPR120C.
GeneIDi856237.
KEGGisce:YPR120C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M91209 Genomic DNA. Translation: AAA34503.1 .
X70435 Genomic DNA. Translation: CAA49893.1 .
U40828 Genomic DNA. Translation: AAB68061.1 .
BK006949 Genomic DNA. Translation: DAA11535.1 .
PIRi S31290.
RefSeqi NP_015445.1. NM_001184217.1.

3D structure databases

ProteinModelPortali P30283.
SMRi P30283. Positions 159-412.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 36288. 203 interactions.
DIPi DIP-2710N.
IntActi P30283. 24 interactions.
MINTi MINT-481362.
STRINGi 4932.YPR120C.

Proteomic databases

PaxDbi P30283.
PeptideAtlasi P30283.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YPR120C ; YPR120C ; YPR120C .
GeneIDi 856237.
KEGGi sce:YPR120C.

Organism-specific databases

CYGDi YPR120c.
SGDi S000006324. CLB5.

Phylogenomic databases

eggNOGi COG5024.
GeneTreei ENSGT00750000117276.
HOGENOMi HOG000000929.
KOi K06651.
OMAi LSINLMD.
OrthoDBi EOG7FNCJX.

Enzyme and pathway databases

BioCyci YEAST:G3O-34259-MONOMER.
Reactomei REACT_188466. Regulation of APC/C activators between G1/S and early anaphase.
REACT_188487. Cyclin A/B1 associated events during G2/M transition.
REACT_188488. G2/M DNA replication checkpoint.
REACT_188908. Condensation of Prometaphase Chromosomes.
REACT_188916. MASTL Facilitates Mitotic Progression.
REACT_205363. Cyclin B2 mediated events.
REACT_211772. E2F-enabled inhibition of pre-replication complex formation.
REACT_224510. Depolymerisation of the Nuclear Lamina.

Miscellaneous databases

NextBioi 981496.

Gene expression databases

Genevestigatori P30283.

Family and domain databases

Gene3Di 1.10.472.10. 2 hits.
InterProi IPR013763. Cyclin-like.
IPR014400. Cyclin_A/B/D/E/F.
IPR004367. Cyclin_C-dom.
IPR006671. Cyclin_N.
[Graphical view ]
Pfami PF02984. Cyclin_C. 1 hit.
PF00134. Cyclin_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF001771. Cyclin_A_B_D_E. 1 hit.
SMARTi SM00385. CYCLIN. 2 hits.
[Graphical view ]
SUPFAMi SSF47954. SSF47954. 2 hits.
PROSITEi PS00292. CYCLINS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "CLB5: a novel B cyclin from budding yeast with a role in S phase."
    Epstein C.B., Cross F.R.
    Genes Dev. 6:1695-1706(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: BF264-15D.
  2. "CLB5 and CLB6, a new pair of B cyclins involved in DNA replication in Saccharomyces cerevisiae."
    Schwob E., Nasmyth K.
    Genes Dev. 7:1160-1175(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204510 / AB320.
  3. "A new pair of B-type cyclins from Saccharomyces cerevisiae that function early in the cell cycle."
    Kuehne C., Linder P.
    EMBO J. 12:3437-3447(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  4. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI."
    Bussey H., Storms R.K., Ahmed A., Albermann K., Allen E., Ansorge W., Araujo R., Aparicio A., Barrell B.G., Badcock K., Benes V., Botstein D., Bowman S., Brueckner M., Carpenter J., Cherry J.M., Chung E., Churcher C.M.
    , Coster F., Davis K., Davis R.W., Dietrich F.S., Delius H., DiPaolo T., Dubois E., Duesterhoeft A., Duncan M., Floeth M., Fortin N., Friesen J.D., Fritz C., Goffeau A., Hall J., Hebling U., Heumann K., Hilbert H., Hillier L.W., Hunicke-Smith S., Hyman R.W., Johnston M., Kalman S., Kleine K., Komp C., Kurdi O., Lashkari D., Lew H., Lin A., Lin D., Louis E.J., Marathe R., Messenguy F., Mewes H.-W., Mirtipati S., Moestl D., Mueller-Auer S., Namath A., Nentwich U., Oefner P., Pearson D., Petel F.X., Pohl T.M., Purnelle B., Rajandream M.A., Rechmann S., Rieger M., Riles L., Roberts D., Schaefer M., Scharfe M., Scherens B., Schramm S., Schroeder M., Sdicu A.-M., Tettelin H., Urrestarazu L.A., Ushinsky S., Vierendeels F., Vissers S., Voss H., Walsh S.V., Wambutt R., Wang Y., Wedler E., Wedler H., Winnett E., Zhong W.-W., Zollner A., Vo D.H., Hani J.
    Nature 387:103-105(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  5. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  6. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  7. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
    Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
    Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiCGS5_YEAST
AccessioniPrimary (citable) accession number: P30283
Secondary accession number(s): D6W4B9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: September 3, 2014
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 521 molecules/cell in log phase SD medium.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XVI
    Yeast (Saccharomyces cerevisiae) chromosome XVI: entries and gene names

External Data

Dasty 3

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