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P30282 (CCND3_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 127. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
G1/S-specific cyclin-D3
Gene names
Name:Ccnd3
Synonyms:Cyl-3
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length292 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Regulatory component of the cyclin D3-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G1/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G1 phase. Hypophosphorylates RB1 in early G1 phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D3/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex.

Subunit structure

Interacts with the CDK4 and CDK6 protein kinases to form a serine/threonine kinase holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex. Component of the ternary complex cyclin D/CDK4/CDKN1B required for nuclear translocation and modulation of CDK4-mediated kinase activity. Can form similar complexes with either CDKN1A or CDKN2A. Interacts with ATF5 and EIF3K By similarity.

Subcellular location

Nucleus By similarity. Cytoplasm By similarity. Membrane By similarity. Note: Cyclin D-CDK4 complexes accumulate at the nuclear membrane and are then translocated to the nucleus through interaction with KIP/CIP family members By similarity.

Post-translational modification

Polyubiquitinated by the SCF(FBXL2) complex, leading to proteasomal degradation By similarity.

Sequence similarities

Belongs to the cyclin family. Cyclin D subfamily.

Contains 1 cyclin N-terminal domain.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

Cdk6Q642612EBI-847337,EBI-847380

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 292292G1/S-specific cyclin-D3
PRO_0000080443

Regions

Domain27 – 152126Cyclin N-terminal

Amino acid modifications

Modified residue2791Phosphoserine By similarity

Experimental info

Sequence conflict2391C → Y in AAH04076. Ref.3

Sequences

Sequence LengthMass (Da)Tools
P30282 [UniParc].

Last modified April 1, 1993. Version 1.
Checksum: 5441639A9B1B1475

FASTA29232,411
        10         20         30         40         50         60 
MELLCCEGTR HAPRAGPDPR LLGDQRVLQS LLRLEERYVP RASYFQCVQK EIKPHMRKML 

        70         80         90        100        110        120 
AYWMLEVCEE QRCEEDVFPL AMNYLDRYLS CVPTRKAQLQ LLGTVCLLLA SKLRETTPLT 

       130        140        150        160        170        180 
IEKLCIYTDQ AVAPWQLREW EVLVLGKLKW DLAAVIAHDF LALILHRLSL PSDRQALVKK 

       190        200        210        220        230        240 
HAQTFLALCA TDYTFAMYPP SMIATGSIGA AVLGLGACSM SADELTELLA GITGTEVDCL 

       250        260        270        280        290 
RACQEQIEAA LRESLREAAQ TAPSPVPKAP RGSSSQGPSQ TSTPTDVTAI HL 

« Hide

References

« Hide 'large scale' references
[1]"Colony-stimulating factor 1 regulates novel cyclins during the G1 phase of the cell cycle."
Matsushime H., Roussel M.F., Ashmun R.A., Sherr C.J.
Cell 65:701-713(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Characterization of the mouse cyclin D3 gene: exon/intron organization and promoter activity."
Wang Z., Sicinski P., Weinberg R.A., Zhang Y., Ravid K.
Genomics 35:156-163(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: 129/Sv.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Mammary gland.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M86183 mRNA. Translation: AAA37504.1.
U43844 Genomic DNA. Translation: AAC53363.1.
BC004076 mRNA. Translation: AAH04076.1.
BC005605 mRNA. Translation: AAH05605.1.
PIRC40035.
RefSeqNP_001075104.1. NM_001081635.1.
NP_001075105.1. NM_001081636.1.
NP_031658.1. NM_007632.2.
UniGeneMm.27291.

3D structure databases

ProteinModelPortalP30282.
SMRP30282. Positions 23-254.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid198550. 10 interactions.
IntActP30282. 5 interactions.
MINTMINT-1510794.

PTM databases

PhosphoSiteP30282.

Proteomic databases

PaxDbP30282.
PRIDEP30282.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000037333; ENSMUSP00000040488; ENSMUSG00000034165.
ENSMUST00000171031; ENSMUSP00000126141; ENSMUSG00000034165.
ENSMUST00000182209; ENSMUSP00000138091; ENSMUSG00000034165.
ENSMUST00000183044; ENSMUSP00000138220; ENSMUSG00000034165.
ENSMUST00000183177; ENSMUSP00000138640; ENSMUSG00000034165.
GeneID12445.
KEGGmmu:12445.
UCSCuc008cvk.1. mouse.

Organism-specific databases

CTD896.
MGIMGI:88315. Ccnd3.

Phylogenomic databases

eggNOGNOG294373.
HOGENOMHOG000008182.
HOVERGENHBG050837.
InParanoidP30282.
KOK10152.
OMAISGETEC.
OrthoDBEOG7J447H.
PhylomeDBP30282.
TreeFamTF101004.

Gene expression databases

ArrayExpressP30282.
BgeeP30282.
CleanExMM_CCND3.
GenevestigatorP30282.

Family and domain databases

Gene3D1.10.472.10. 2 hits.
InterProIPR013763. Cyclin-like.
IPR014400. Cyclin_A/B/D/E.
IPR004367. Cyclin_C-dom.
IPR015451. Cyclin_D.
IPR006671. Cyclin_N.
[Graphical view]
PANTHERPTHR10177:SF65. PTHR10177:SF65. 1 hit.
PfamPF02984. Cyclin_C. 1 hit.
PF00134. Cyclin_N. 1 hit.
[Graphical view]
PIRSFPIRSF001771. Cyclin_A_B_D_E. 1 hit.
SMARTSM00385. CYCLIN. 1 hit.
[Graphical view]
SUPFAMSSF47954. SSF47954. 2 hits.
PROSITEPS00292. CYCLINS. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSCCND3. mouse.
NextBio281262.
PROP30282.
SOURCESearch...

Entry information

Entry nameCCND3_MOUSE
AccessionPrimary (citable) accession number: P30282
Secondary accession number(s): Q62391, Q99KP2
Entry history
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: April 16, 2014
This is version 127 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot