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P30282

- CCND3_MOUSE

UniProt

P30282 - CCND3_MOUSE

Protein

G1/S-specific cyclin-D3

Gene

Ccnd3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 131 (01 Oct 2014)
      Sequence version 1 (01 Apr 1993)
      Previous versions | rss
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    Functioni

    Regulatory component of the cyclin D3-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G1/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G1 phase. Hypophosphorylates RB1 in early G1 phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D3/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex.

    GO - Molecular functioni

    1. cyclin-dependent protein serine/threonine kinase activity Source: MGI
    2. protein binding Source: IntAct

    GO - Biological processi

    1. cell cycle Source: UniProtKB-KW
    2. cell division Source: UniProtKB-KW
    3. positive regulation of cyclin-dependent protein serine/threonine kinase activity Source: Ensembl
    4. regulation of cell cycle Source: MGI
    5. signal transduction Source: MGI
    6. T cell proliferation Source: MGI

    Keywords - Molecular functioni

    Cyclin

    Keywords - Biological processi

    Cell cycle, Cell division

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    G1/S-specific cyclin-D3
    Gene namesi
    Name:Ccnd3
    Synonyms:Cyl-3
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 17

    Organism-specific databases

    MGIiMGI:88315. Ccnd3.

    Subcellular locationi

    Nucleus By similarity. Cytoplasm By similarity. Membrane By similarity
    Note: Cyclin D-CDK4 complexes accumulate at the nuclear membrane and are then translocated to the nucleus through interaction with KIP/CIP family members.By similarity

    GO - Cellular componenti

    1. cyclin-dependent protein kinase holoenzyme complex Source: Ensembl
    2. cytoplasm Source: UniProtKB-SubCell
    3. membrane Source: UniProtKB-SubCell
    4. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Membrane, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 292292G1/S-specific cyclin-D3PRO_0000080443Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei279 – 2791PhosphoserineBy similarity

    Post-translational modificationi

    Polyubiquitinated by the SCF(FBXL2) complex, leading to proteasomal degradation.By similarity

    Keywords - PTMi

    Phosphoprotein, Ubl conjugation

    Proteomic databases

    MaxQBiP30282.
    PaxDbiP30282.
    PRIDEiP30282.

    PTM databases

    PhosphoSiteiP30282.

    Expressioni

    Gene expression databases

    ArrayExpressiP30282.
    BgeeiP30282.
    CleanExiMM_CCND3.
    GenevestigatoriP30282.

    Interactioni

    Subunit structurei

    Interacts with the CDK4 and CDK6 protein kinases to form a serine/threonine kinase holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex. Component of the ternary complex cyclin D/CDK4/CDKN1B required for nuclear translocation and modulation of CDK4-mediated kinase activity. Can form similar complexes with either CDKN1A or CDKN2A. Interacts with ATF5 and EIF3K By similarity.By similarity

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    Cdk6Q642612EBI-847337,EBI-847380

    Protein-protein interaction databases

    BioGridi198550. 10 interactions.
    IntActiP30282. 5 interactions.
    MINTiMINT-1510794.

    Structurei

    3D structure databases

    ProteinModelPortaliP30282.
    SMRiP30282. Positions 23-254.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini27 – 152126Cyclin N-terminalAdd
    BLAST

    Sequence similaritiesi

    Belongs to the cyclin family. Cyclin D subfamily.Curated
    Contains 1 cyclin N-terminal domain.Curated

    Phylogenomic databases

    eggNOGiNOG294373.
    HOGENOMiHOG000008182.
    HOVERGENiHBG050837.
    InParanoidiP30282.
    KOiK10152.
    OMAiISGETEC.
    OrthoDBiEOG7J447H.
    PhylomeDBiP30282.
    TreeFamiTF101004.

    Family and domain databases

    Gene3Di1.10.472.10. 2 hits.
    InterProiIPR013763. Cyclin-like.
    IPR014400. Cyclin_A/B/D/E/F.
    IPR004367. Cyclin_C-dom.
    IPR015451. Cyclin_D.
    IPR006671. Cyclin_N.
    [Graphical view]
    PANTHERiPTHR10177:SF65. PTHR10177:SF65. 1 hit.
    PfamiPF02984. Cyclin_C. 1 hit.
    PF00134. Cyclin_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001771. Cyclin_A_B_D_E. 1 hit.
    SMARTiSM00385. CYCLIN. 1 hit.
    [Graphical view]
    SUPFAMiSSF47954. SSF47954. 2 hits.
    PROSITEiPS00292. CYCLINS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P30282-1 [UniParc]FASTAAdd to Basket

    « Hide

    MELLCCEGTR HAPRAGPDPR LLGDQRVLQS LLRLEERYVP RASYFQCVQK    50
    EIKPHMRKML AYWMLEVCEE QRCEEDVFPL AMNYLDRYLS CVPTRKAQLQ 100
    LLGTVCLLLA SKLRETTPLT IEKLCIYTDQ AVAPWQLREW EVLVLGKLKW 150
    DLAAVIAHDF LALILHRLSL PSDRQALVKK HAQTFLALCA TDYTFAMYPP 200
    SMIATGSIGA AVLGLGACSM SADELTELLA GITGTEVDCL RACQEQIEAA 250
    LRESLREAAQ TAPSPVPKAP RGSSSQGPSQ TSTPTDVTAI HL 292
    Length:292
    Mass (Da):32,411
    Last modified:April 1, 1993 - v1
    Checksum:i5441639A9B1B1475
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti239 – 2391C → Y in AAH04076. (PubMed:15489334)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M86183 mRNA. Translation: AAA37504.1.
    U43844 Genomic DNA. Translation: AAC53363.1.
    BC004076 mRNA. Translation: AAH04076.1.
    BC005605 mRNA. Translation: AAH05605.1.
    CCDSiCCDS28850.1.
    PIRiC40035.
    RefSeqiNP_001075104.1. NM_001081635.1.
    NP_001075105.1. NM_001081636.1.
    NP_031658.1. NM_007632.2.
    UniGeneiMm.27291.

    Genome annotation databases

    EnsembliENSMUST00000037333; ENSMUSP00000040488; ENSMUSG00000034165.
    ENSMUST00000171031; ENSMUSP00000126141; ENSMUSG00000034165.
    ENSMUST00000182209; ENSMUSP00000138091; ENSMUSG00000034165.
    ENSMUST00000183044; ENSMUSP00000138220; ENSMUSG00000034165.
    ENSMUST00000183177; ENSMUSP00000138640; ENSMUSG00000034165.
    GeneIDi12445.
    KEGGimmu:12445.
    UCSCiuc008cvk.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M86183 mRNA. Translation: AAA37504.1 .
    U43844 Genomic DNA. Translation: AAC53363.1 .
    BC004076 mRNA. Translation: AAH04076.1 .
    BC005605 mRNA. Translation: AAH05605.1 .
    CCDSi CCDS28850.1.
    PIRi C40035.
    RefSeqi NP_001075104.1. NM_001081635.1.
    NP_001075105.1. NM_001081636.1.
    NP_031658.1. NM_007632.2.
    UniGenei Mm.27291.

    3D structure databases

    ProteinModelPortali P30282.
    SMRi P30282. Positions 23-254.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 198550. 10 interactions.
    IntActi P30282. 5 interactions.
    MINTi MINT-1510794.

    PTM databases

    PhosphoSitei P30282.

    Proteomic databases

    MaxQBi P30282.
    PaxDbi P30282.
    PRIDEi P30282.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000037333 ; ENSMUSP00000040488 ; ENSMUSG00000034165 .
    ENSMUST00000171031 ; ENSMUSP00000126141 ; ENSMUSG00000034165 .
    ENSMUST00000182209 ; ENSMUSP00000138091 ; ENSMUSG00000034165 .
    ENSMUST00000183044 ; ENSMUSP00000138220 ; ENSMUSG00000034165 .
    ENSMUST00000183177 ; ENSMUSP00000138640 ; ENSMUSG00000034165 .
    GeneIDi 12445.
    KEGGi mmu:12445.
    UCSCi uc008cvk.1. mouse.

    Organism-specific databases

    CTDi 896.
    MGIi MGI:88315. Ccnd3.

    Phylogenomic databases

    eggNOGi NOG294373.
    HOGENOMi HOG000008182.
    HOVERGENi HBG050837.
    InParanoidi P30282.
    KOi K10152.
    OMAi ISGETEC.
    OrthoDBi EOG7J447H.
    PhylomeDBi P30282.
    TreeFami TF101004.

    Miscellaneous databases

    ChiTaRSi CCND3. mouse.
    NextBioi 281262.
    PROi P30282.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P30282.
    Bgeei P30282.
    CleanExi MM_CCND3.
    Genevestigatori P30282.

    Family and domain databases

    Gene3Di 1.10.472.10. 2 hits.
    InterProi IPR013763. Cyclin-like.
    IPR014400. Cyclin_A/B/D/E/F.
    IPR004367. Cyclin_C-dom.
    IPR015451. Cyclin_D.
    IPR006671. Cyclin_N.
    [Graphical view ]
    PANTHERi PTHR10177:SF65. PTHR10177:SF65. 1 hit.
    Pfami PF02984. Cyclin_C. 1 hit.
    PF00134. Cyclin_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001771. Cyclin_A_B_D_E. 1 hit.
    SMARTi SM00385. CYCLIN. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47954. SSF47954. 2 hits.
    PROSITEi PS00292. CYCLINS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Colony-stimulating factor 1 regulates novel cyclins during the G1 phase of the cell cycle."
      Matsushime H., Roussel M.F., Ashmun R.A., Sherr C.J.
      Cell 65:701-713(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Characterization of the mouse cyclin D3 gene: exon/intron organization and promoter activity."
      Wang Z., Sicinski P., Weinberg R.A., Zhang Y., Ravid K.
      Genomics 35:156-163(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: 129/Sv.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Mammary gland.

    Entry informationi

    Entry nameiCCND3_MOUSE
    AccessioniPrimary (citable) accession number: P30282
    Secondary accession number(s): Q62391, Q99KP2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 1, 1993
    Last sequence update: April 1, 1993
    Last modified: October 1, 2014
    This is version 131 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3