Reviewed, UniProtKB/Swiss-Prot P30281 (CCND3_HUMAN)

Names and origin

Protein names

Recommended name:
    G1/S-specific cyclin-D3

Gene names

Name:

CCND3

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	292 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Essential for the control of the cell cycle at the G1/S (start) transition. Potentiates the transcriptional activity of ATF5. Ref.10
Subunit structure	Interacts with the CDK4 and CDK6 protein kinases to form a serine/threonine kinase holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex. Interacts with ATF5. Interacts with EIF3K. Ref.10 Ref.11
Subcellular location	Cytoplasm. Nucleus Ref.10.
Sequence similarities	Belongs to the cyclin family. Cyclin D subfamily.

Ontologies

Keywords
Biological process	Cell cycle Cell division
Cellular component	Cytoplasm Nucleus
Coding sequence diversity	Polymorphism
Molecular function	Cyclin
PTM	Phosphoprotein
Technical term	3D-structure Complete proteome
Gene Ontology (GO)
Biological process	cell cycle Inferred from electronic annotation. Source: UniProtKB-KW cell division Inferred from electronic annotation. Source: UniProtKB-KW positive regulation of cyclin-dependent protein kinase activity Inferred from direct assay. Source: UniProtKB positive regulation of protein amino acid phosphorylation Inferred from direct assay. Source: UniProtKB
Cellular component	cyclin-dependent protein kinase holoenzyme complex Inferred from direct assay. Source: UniProtKB cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	protein kinase binding Inferred from physical interaction. Source: UniProtKB
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
CDK4	P11802	3	EBI-375013,EBI-295644
CDK6	Q00534	1	EBI-375013,EBI-295663
CDKN1A	P38936	1	EBI-375013,EBI-375077
MCM10	Q7L590	1	EBI-375013,EBI-374912
PFTK1	O94921	4	EBI-375013,EBI-1043945
PPP1CB	P62140	1	EBI-375013,EBI-352350
PPP1CC	P36873-1	1	EBI-375013,EBI-356289

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 292

292

G1/S-specific cyclin-D3

PRO_0000080442

Amino acid modifications

Modified residue

263

1

Phosphoserine

Modified residue

279

1

Phosphoserine Ref.13

Natural variations

Natural variant

134

1

P → S: dbSNP rs3218089.

VAR_020412

Natural variant

253

1

E → D: dbSNP rs33966734.

VAR_033726

Natural variant

259

1

S → A: dbSNP rs1051130. Ref.1 Ref.3 Ref.5 Ref.7

VAR_014205

Secondary structure

1

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292

Helix Strand Turn

Details...

Helix

25 – 34

10

Helix

35 – 38

4

Turn

45 – 47

3

Turn

49 – 51

3

Helix

54 – 70

17

Helix

77 – 91

15

Helix

96 – 98

3

Turn

99 – 101

3

Helix

105 – 114

10

Helix

123 – 127

5

Turn

128 – 130

3

Helix

134 – 144

11

Helix

157 – 160

4

Helix

161 – 166

6

Turn

172 – 174

3

Helix

175 – 191

17

Helix

193 – 195

3

Helix

200 – 204

5

Helix

224 – 229

6

Helix

237 – 252

16

Sequences

	Sequence		Length	Mass (Da)
	P30281-1 [UniParc]. Last modified May 15, 2002. Version 2. Checksum: 16E7B1604FEB0029	FASTA	292	32,520
	10 20 30 40 50 60 MELLCCEGTR HAPRAGPDPR LLGDQRVLQS LLRLEERYVP RASYFQCVQR EIKPHMRKML 70 80 90 100 110 120 AYWMLEVCEE QRCEEEVFPL AMNYLDRYLS CVPTRKAQLQ LLGAVCMLLA SKLRETTPLT 130 140 150 160 170 180 IEKLCIYTDH AVSPRQLRDW EVLVLGKLKW DLAAVIAHDF LAFILHRLSL PRDRQALVKK 190 200 210 220 230 240 HAQTFLALCA TDYTFAMYPP SMIATGSIGA AVQGLGACSM SGDELTELLA GITGTEVDCL 250 260 270 280 290 RACQEQIEAA LRESLREASQ TSSSPAPKAP RGSSSQGPSQ TSTPTDVTAI HL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning and chromosomal mapping of CCND genes encoding human D-type cyclins." Xiong Y., Menninger J., Beach D., Ward D.C. Genomics 13:575-584(1992) [PubMed: 1386336] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ALA-259.
[2]	"Cloning and characterization of human cyclin D3, a cDNA closely related in sequence to the PRAD1/cyclin D1 proto-oncogene." Motokura T., Keyomarsi K., Kronenberg H.M., Arnold A. J. Biol. Chem. 267:20412-20415(1992) [PubMed: 1383201] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	NIEHS SNPs program Submitted (JUN-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT ALA-259.
[4]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Umbilical cord blood.
[5]	"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)." Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B. Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ALA-259.
[6]	"The DNA sequence and analysis of human chromosome 6." Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S. Nature 425:805-811(2003) [PubMed: 14574404] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ALA-259.
[8]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Lung.
[9]	"Genomic organization, chromosomal localization, and independent expression of human cyclin D genes." Inaba T., Matsushime H., Valentine M., Roussel M.F., Sherr C.J., Look A.T. Genomics 13:565-574(1992) [PubMed: 1386335] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 52-237. Tissue: Placenta.
[10]	"Cyclin D3 interacts with human activating transcription factor 5 and potentiates its transcription activity." Liu W., Sun M., Jiang J., Shen X., Sun Q., Liu W., Shen H., Gu J. Biochem. Biophys. Res. Commun. 321:954-960(2004) [PubMed: 15358120] [Abstract] Cited for: INTERACTION WITH ATF5, FUNCTION, SUBCELLULAR LOCATION.
[11]	"Identification of the p28 subunit of eukaryotic initiation factor 3(eIF3k) as a new interaction partner of cyclin D3." Shen X., Yang Y., Liu W., Sun M., Jiang J., Zong H., Gu J. FEBS Lett. 573:139-146(2004) [PubMed: 15327989] [Abstract] Cited for: INTERACTION WITH EIF3K.
[12]	"Large-scale proteomics analysis of the human kinome." Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G., Mann M., Daub H. Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed: 19369195] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-263, MASS SPECTROMETRY.
[13]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed: 19690332] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-279, MASS SPECTROMETRY. Tissue: T-cell.
+	Additional computationally mapped references.

Web resources

NIEHS-SNPs

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

M90814 mRNA. Translation: AAA51927.1.
M92287 mRNA. Translation: AAA52137.1.
AF517525 Genomic DNA. Translation: AAM51826.1.
AK315421 mRNA. Translation: BAG37810.1.
CR542246 mRNA. Translation: CAG47042.1.
AL160163 Genomic DNA. Translation: CAI23491.1.
CH471081 Genomic DNA. Translation: EAX04071.1.
BC011616 mRNA. Translation: AAH11616.1.
M88087 , M88084, M88085, M88086 Genomic DNA. Translation: AAA51929.1.

IPI

IPI00025817.

PIR

B42822.

RefSeq

NP_001129489.1.
NP_001129597.1.
NP_001129598.1.
NP_001751.1.

UniGene

Hs.534307

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
3G33	X-ray	3.00	B/D	1-292	[»]

ModBase

Search...

Protein-protein interaction databases

IntAct

P30281. 12 interactions.

STRING

P30281.

PTM databases

PhosphoSite

P30281.

Proteomic databases

PRIDE

P30281.

Genome annotation databases

Ensembl

ENST00000372991; ENSP00000362082; ENSG00000112576; Homo sapiens. [Genome view]

GeneID

896.

KEGG

hsa:896.

UCSC

uc003orn.1. human.

Organism-specific databases

CTD

896.

GeneCards

GC06M042010.

H-InvDB

HIX0005877.

HGNC

HGNC:1585. CCND3.

HPA

CAB000116.

MIM

123834. gene.

PharmGKB

PA26152.

GenAtlas

Search...

Phylogenomic databases

eggNOG

prNOG12790.

HOGENOM

HBG713252.

HOVERGEN

P30281.

InParanoid

P30281.

OMA

YTDHSVS.

PhylomeDB

P30281.

Enzyme and pathway databases

Pathway_Interaction_DB

ar_pathway. Coregulation of Androgen receptor activity.
il2_stat5pathway. IL2 signaling events mediated by STAT5.

Reactome

REACT_152. Cell Cycle, Mitotic.

Gene expression databases

ArrayExpress

P30281.

Bgee

P30281.

CleanEx

HS_CCND3.

Genevestigator

P30281.

GermOnline

ENSG00000112576. Homo sapiens.

Family and domain databases

InterPro

IPR015451. CycD.
IPR006670. Cyclin.
IPR011028. Cyclin-like.
IPR014400. Cyclin_A_B_D_E.
IPR004367. Cyclin_C.
IPR006671. Cyclin_N.
IPR013763. Cyclin_related.
[Graphical view]

Gene3D

G3DSA:1.10.472.10. Cyclin_related. 1 hit.

PANTHER

PTHR10177:SF12. CycD. 1 hit.

Pfam

PF02984. Cyclin_C. 1 hit.
PF00134. Cyclin_N. 1 hit.
[Graphical view]

PIRSF

PIRSF001771. Cyclin_A_B_D_E. 1 hit.

SMART

SM00385. CYCLIN. 1 hit.
[Graphical view]

PROSITE

PS00292. CYCLINS. 1 hit.
[Graphical view]

ProtoNet

Search...

Other Resources

NextBio

3702.

SOURCE

Search...

Entry information

Entry name

CCND3_HUMAN

Accession

Primary (citable) accession number: P30281
Secondary accession number(s): B2RD63 , Q5T8J0, Q6FG62, Q96F49

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 1, 1993
Last sequence update:	May 15, 2002
Last modified:	February 9, 2010
This is version 107 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.