Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

G1/S-specific cyclin-D3

Gene

CCND3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Regulatory component of the cyclin D3-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G1/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G1 phase. Hypophosphorylates RB1 in early G1 phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D3/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex.1 Publication

GO - Molecular functioni

  • cyclin-dependent protein serine/threonine kinase activity Source: Ensembl
  • protein kinase binding Source: BHF-UCL

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Cyclin

Keywords - Biological processi

Cell cycle, Cell division

Enzyme and pathway databases

BioCyciZFISH:ENSG00000112576-MONOMER.
ReactomeiR-HSA-381340. Transcriptional regulation of white adipocyte differentiation.
R-HSA-5687128. MAPK6/MAPK4 signaling.
R-HSA-69231. Cyclin D associated events in G1.
SignaLinkiP30281.
SIGNORiP30281.

Names & Taxonomyi

Protein namesi
Recommended name:
G1/S-specific cyclin-D3
Gene namesi
Name:CCND3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:1585. CCND3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi896.
OpenTargetsiENSG00000112576.
PharmGKBiPA26152.

Chemistry databases

ChEMBLiCHEMBL2422.

Polymorphism and mutation databases

BioMutaiCCND3.
DMDMi20981685.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000804421 – 292G1/S-specific cyclin-D3Add BLAST292

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei264PhosphoserineBy similarity1
Modified residuei279PhosphoserineCombined sources1

Post-translational modificationi

Polyubiquitinated by the SCF(FBXL2) complex, leading to proteasomal degradation.1 Publication

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP30281.
MaxQBiP30281.
PaxDbiP30281.
PeptideAtlasiP30281.
PRIDEiP30281.

PTM databases

iPTMnetiP30281.
PhosphoSitePlusiP30281.

Expressioni

Gene expression databases

BgeeiENSG00000112576.
CleanExiHS_CCND3.
ExpressionAtlasiP30281. baseline and differential.
GenevisibleiP30281. HS.

Organism-specific databases

HPAiCAB000116.
HPA055107.

Interactioni

Subunit structurei

Interacts with the CDK4 and CDK6 protein kinases to form a serine/threonine kinase holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex. Interacts with ATF5. Interacts with EIF3K. Component of the ternary complex cyclin D/CDK4/CDKN1B required for nuclear translocation and modulation of CDK4-mediated kinase activity. Can form similar complexes with either CDKN1A or CDKN2A.5 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
AKAP8Q5VK716EBI-375013,EBI-11601938From a different organism.
CDK14O949215EBI-375013,EBI-1043945
CDK4P1180220EBI-375013,EBI-295644
CDK5Q005354EBI-375013,EBI-1041567
CDK6Q0053413EBI-375013,EBI-295663
CDKN1AP3893617EBI-375013,EBI-375077
ICP0P083933EBI-375013,EBI-6148881From a different organism.
POLR3GLQ9BT433EBI-375013,EBI-2855862
TFIP11Q9UBB93EBI-375013,EBI-1105213

GO - Molecular functioni

  • protein kinase binding Source: BHF-UCL

Protein-protein interaction databases

BioGridi107336. 50 interactors.
DIPiDIP-31734N.
IntActiP30281. 35 interactors.
MINTiMINT-1201666.
STRINGi9606.ENSP00000362082.

Chemistry databases

BindingDBiP30281.

Structurei

Secondary structure

1292
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi24 – 34Combined sources11
Helixi35 – 38Combined sources4
Turni45 – 47Combined sources3
Turni49 – 51Combined sources3
Helixi54 – 70Combined sources17
Helixi77 – 91Combined sources15
Helixi96 – 98Combined sources3
Helixi99 – 114Combined sources16
Helixi123 – 127Combined sources5
Turni128 – 130Combined sources3
Helixi134 – 147Combined sources14
Turni148 – 150Combined sources3
Helixi157 – 160Combined sources4
Helixi161 – 166Combined sources6
Turni172 – 174Combined sources3
Helixi175 – 191Combined sources17
Helixi193 – 195Combined sources3
Helixi200 – 213Combined sources14
Helixi222 – 233Combined sources12
Helixi237 – 252Combined sources16

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3G33X-ray3.00B/D1-292[»]
ProteinModelPortaliP30281.
SMRiP30281.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP30281.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini27 – 152Cyclin N-terminalAdd BLAST126

Sequence similaritiesi

Belongs to the cyclin family. Cyclin D subfamily.Curated
Contains 1 cyclin N-terminal domain.Curated

Phylogenomic databases

eggNOGiKOG0656. Eukaryota.
ENOG410XRKC. LUCA.
GeneTreeiENSGT00760000118939.
HOGENOMiHOG000008182.
HOVERGENiHBG050837.
InParanoidiP30281.
KOiK10152.
OMAiLAFWMLE.
OrthoDBiEOG091G0URX.
PhylomeDBiP30281.
TreeFamiTF101004.

Family and domain databases

Gene3Di1.10.472.10. 2 hits.
InterProiIPR013763. Cyclin-like.
IPR004367. Cyclin_C-dom.
IPR015451. Cyclin_D.
IPR006671. Cyclin_N.
[Graphical view]
PANTHERiPTHR10177:SF65. PTHR10177:SF65. 1 hit.
PfamiPF02984. Cyclin_C. 1 hit.
PF00134. Cyclin_N. 1 hit.
[Graphical view]
SMARTiSM00385. CYCLIN. 1 hit.
SM01332. Cyclin_C. 1 hit.
[Graphical view]
SUPFAMiSSF47954. SSF47954. 2 hits.
PROSITEiPS00292. CYCLINS. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P30281-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MELLCCEGTR HAPRAGPDPR LLGDQRVLQS LLRLEERYVP RASYFQCVQR
60 70 80 90 100
EIKPHMRKML AYWMLEVCEE QRCEEEVFPL AMNYLDRYLS CVPTRKAQLQ
110 120 130 140 150
LLGAVCMLLA SKLRETTPLT IEKLCIYTDH AVSPRQLRDW EVLVLGKLKW
160 170 180 190 200
DLAAVIAHDF LAFILHRLSL PRDRQALVKK HAQTFLALCA TDYTFAMYPP
210 220 230 240 250
SMIATGSIGA AVQGLGACSM SGDELTELLA GITGTEVDCL RACQEQIEAA
260 270 280 290
LRESLREASQ TSSSPAPKAP RGSSSQGPSQ TSTPTDVTAI HL
Length:292
Mass (Da):32,520
Last modified:May 15, 2002 - v2
Checksum:i16E7B1604FEB0029
GO
Isoform 2 (identifier: P30281-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-81: Missing.

Note: No experimental confirmation available.
Show »
Length:211
Mass (Da):22,887
Checksum:iF88EA393BA1B96DB
GO
Isoform 3 (identifier: P30281-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     67-138: Missing.

Note: No experimental confirmation available.
Show »
Length:220
Mass (Da):24,238
Checksum:i15BC01266FE6BF4B
GO
Isoform 4 (identifier: P30281-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-196: Missing.

Note: No experimental confirmation available.
Show »
Length:96
Mass (Da):9,736
Checksum:i83F7CF9D0B743ED7
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_020412134P → S.Corresponds to variant rs3218089dbSNPEnsembl.1
Natural variantiVAR_033726253E → D.Corresponds to variant rs33966734dbSNPEnsembl.1
Natural variantiVAR_014205259S → A.6 PublicationsCorresponds to variant rs1051130dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0462661 – 196Missing in isoform 4. 1 PublicationAdd BLAST196
Alternative sequenceiVSP_0426491 – 81Missing in isoform 2. 1 PublicationAdd BLAST81
Alternative sequenceiVSP_04626767 – 138Missing in isoform 3. 1 PublicationAdd BLAST72

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M90814 mRNA. Translation: AAA51927.1.
M92287 mRNA. Translation: AAA52137.1.
AF517525 Genomic DNA. Translation: AAM51826.1.
BX400719 mRNA. No translation available.
AK057206 mRNA. Translation: BAG51884.1.
AK097856 mRNA. No translation available.
AK315421 mRNA. Translation: BAG37810.1.
CR542246 mRNA. Translation: CAG47042.1.
AL160163 Genomic DNA. Translation: CAI23491.1.
AL513008 Genomic DNA. No translation available.
CH471081 Genomic DNA. Translation: EAX04071.1.
BC011616 mRNA. Translation: AAH11616.1.
M88087
, M88084, M88085, M88086 Genomic DNA. Translation: AAA51929.1.
CCDSiCCDS47425.1. [P30281-3]
CCDS47426.1. [P30281-2]
CCDS47427.1. [P30281-4]
CCDS4863.1. [P30281-1]
PIRiB42822.
RefSeqiNP_001129489.1. NM_001136017.3. [P30281-2]
NP_001129597.1. NM_001136125.2. [P30281-3]
NP_001129598.1. NM_001136126.2. [P30281-4]
NP_001274356.1. NM_001287427.1.
NP_001274363.1. NM_001287434.1. [P30281-4]
NP_001751.1. NM_001760.4. [P30281-1]
UniGeneiHs.534307.

Genome annotation databases

EnsembliENST00000372988; ENSP00000362079; ENSG00000112576. [P30281-2]
ENST00000372991; ENSP00000362082; ENSG00000112576. [P30281-1]
ENST00000414200; ENSP00000397545; ENSG00000112576. [P30281-3]
ENST00000415497; ENSP00000401595; ENSG00000112576. [P30281-4]
ENST00000511642; ENSP00000426212; ENSG00000112576. [P30281-2]
ENST00000616010; ENSP00000484424; ENSG00000112576. [P30281-4]
GeneIDi896.
KEGGihsa:896.
UCSCiuc003orn.4. human. [P30281-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M90814 mRNA. Translation: AAA51927.1.
M92287 mRNA. Translation: AAA52137.1.
AF517525 Genomic DNA. Translation: AAM51826.1.
BX400719 mRNA. No translation available.
AK057206 mRNA. Translation: BAG51884.1.
AK097856 mRNA. No translation available.
AK315421 mRNA. Translation: BAG37810.1.
CR542246 mRNA. Translation: CAG47042.1.
AL160163 Genomic DNA. Translation: CAI23491.1.
AL513008 Genomic DNA. No translation available.
CH471081 Genomic DNA. Translation: EAX04071.1.
BC011616 mRNA. Translation: AAH11616.1.
M88087
, M88084, M88085, M88086 Genomic DNA. Translation: AAA51929.1.
CCDSiCCDS47425.1. [P30281-3]
CCDS47426.1. [P30281-2]
CCDS47427.1. [P30281-4]
CCDS4863.1. [P30281-1]
PIRiB42822.
RefSeqiNP_001129489.1. NM_001136017.3. [P30281-2]
NP_001129597.1. NM_001136125.2. [P30281-3]
NP_001129598.1. NM_001136126.2. [P30281-4]
NP_001274356.1. NM_001287427.1.
NP_001274363.1. NM_001287434.1. [P30281-4]
NP_001751.1. NM_001760.4. [P30281-1]
UniGeneiHs.534307.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3G33X-ray3.00B/D1-292[»]
ProteinModelPortaliP30281.
SMRiP30281.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107336. 50 interactors.
DIPiDIP-31734N.
IntActiP30281. 35 interactors.
MINTiMINT-1201666.
STRINGi9606.ENSP00000362082.

Chemistry databases

BindingDBiP30281.
ChEMBLiCHEMBL2422.

PTM databases

iPTMnetiP30281.
PhosphoSitePlusiP30281.

Polymorphism and mutation databases

BioMutaiCCND3.
DMDMi20981685.

Proteomic databases

EPDiP30281.
MaxQBiP30281.
PaxDbiP30281.
PeptideAtlasiP30281.
PRIDEiP30281.

Protocols and materials databases

DNASUi896.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000372988; ENSP00000362079; ENSG00000112576. [P30281-2]
ENST00000372991; ENSP00000362082; ENSG00000112576. [P30281-1]
ENST00000414200; ENSP00000397545; ENSG00000112576. [P30281-3]
ENST00000415497; ENSP00000401595; ENSG00000112576. [P30281-4]
ENST00000511642; ENSP00000426212; ENSG00000112576. [P30281-2]
ENST00000616010; ENSP00000484424; ENSG00000112576. [P30281-4]
GeneIDi896.
KEGGihsa:896.
UCSCiuc003orn.4. human. [P30281-1]

Organism-specific databases

CTDi896.
DisGeNETi896.
GeneCardsiCCND3.
HGNCiHGNC:1585. CCND3.
HPAiCAB000116.
HPA055107.
MIMi123834. gene.
neXtProtiNX_P30281.
OpenTargetsiENSG00000112576.
PharmGKBiPA26152.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0656. Eukaryota.
ENOG410XRKC. LUCA.
GeneTreeiENSGT00760000118939.
HOGENOMiHOG000008182.
HOVERGENiHBG050837.
InParanoidiP30281.
KOiK10152.
OMAiLAFWMLE.
OrthoDBiEOG091G0URX.
PhylomeDBiP30281.
TreeFamiTF101004.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000112576-MONOMER.
ReactomeiR-HSA-381340. Transcriptional regulation of white adipocyte differentiation.
R-HSA-5687128. MAPK6/MAPK4 signaling.
R-HSA-69231. Cyclin D associated events in G1.
SignaLinkiP30281.
SIGNORiP30281.

Miscellaneous databases

ChiTaRSiCCND3. human.
EvolutionaryTraceiP30281.
GeneWikiiCyclin_D3.
GenomeRNAii896.
PROiP30281.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000112576.
CleanExiHS_CCND3.
ExpressionAtlasiP30281. baseline and differential.
GenevisibleiP30281. HS.

Family and domain databases

Gene3Di1.10.472.10. 2 hits.
InterProiIPR013763. Cyclin-like.
IPR004367. Cyclin_C-dom.
IPR015451. Cyclin_D.
IPR006671. Cyclin_N.
[Graphical view]
PANTHERiPTHR10177:SF65. PTHR10177:SF65. 1 hit.
PfamiPF02984. Cyclin_C. 1 hit.
PF00134. Cyclin_N. 1 hit.
[Graphical view]
SMARTiSM00385. CYCLIN. 1 hit.
SM01332. Cyclin_C. 1 hit.
[Graphical view]
SUPFAMiSSF47954. SSF47954. 2 hits.
PROSITEiPS00292. CYCLINS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCCND3_HUMAN
AccessioniPrimary (citable) accession number: P30281
Secondary accession number(s): B2RD63
, B3KQ22, E9PAS4, E9PB36, Q5T8J0, Q6FG62, Q96F49
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: May 15, 2002
Last modified: November 30, 2016
This is version 176 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.