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P30281

- CCND3_HUMAN

UniProt

P30281 - CCND3_HUMAN

Protein

G1/S-specific cyclin-D3

Gene

CCND3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 153 (01 Oct 2014)
      Sequence version 2 (15 May 2002)
      Previous versions | rss
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    Functioni

    Regulatory component of the cyclin D3-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G1/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G1 phase. Hypophosphorylates RB1 in early G1 phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D3/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex.1 Publication

    GO - Molecular functioni

    1. cyclin-dependent protein serine/threonine kinase activity Source: Ensembl
    2. protein binding Source: IntAct
    3. protein kinase binding Source: BHF-UCL

    GO - Biological processi

    1. cell cycle Source: UniProtKB-KW
    2. cell division Source: UniProtKB-KW
    3. positive regulation of cyclin-dependent protein serine/threonine kinase activity Source: BHF-UCL
    4. positive regulation of protein phosphorylation Source: BHF-UCL
    5. signal transduction Source: Ensembl
    6. T cell proliferation Source: Ensembl

    Keywords - Molecular functioni

    Cyclin

    Keywords - Biological processi

    Cell cycle, Cell division

    Enzyme and pathway databases

    ReactomeiREACT_27161. Transcriptional regulation of white adipocyte differentiation.
    REACT_821. Cyclin D associated events in G1.
    SignaLinkiP30281.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    G1/S-specific cyclin-D3
    Gene namesi
    Name:CCND3
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 6

    Organism-specific databases

    HGNCiHGNC:1585. CCND3.

    Subcellular locationi

    Nucleus 1 Publication. Cytoplasm 1 Publication. Membrane 1 Publication
    Note: Cyclin D-CDK4 complexes accumulate at the nuclear membrane and are then translocated to the nucleus through interaction with KIP/CIP family members.By similarity

    GO - Cellular componenti

    1. cyclin-dependent protein kinase holoenzyme complex Source: BHF-UCL
    2. cytoplasm Source: UniProtKB-SubCell
    3. membrane Source: UniProtKB-SubCell
    4. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Membrane, Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA26152.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 292292G1/S-specific cyclin-D3PRO_0000080442Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei279 – 2791Phosphoserine1 Publication

    Post-translational modificationi

    Polyubiquitinated by the SCF(FBXL2) complex, leading to proteasomal degradation.1 Publication

    Keywords - PTMi

    Phosphoprotein, Ubl conjugation

    Proteomic databases

    MaxQBiP30281.
    PaxDbiP30281.
    PRIDEiP30281.

    PTM databases

    PhosphoSiteiP30281.

    Expressioni

    Gene expression databases

    ArrayExpressiP30281.
    BgeeiP30281.
    CleanExiHS_CCND3.
    GenevestigatoriP30281.

    Organism-specific databases

    HPAiCAB000116.

    Interactioni

    Subunit structurei

    Interacts with the CDK4 and CDK6 protein kinases to form a serine/threonine kinase holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex. Interacts with ATF5. Interacts with EIF3K. Component of the ternary complex cyclin D/CDK4/CDKN1B required for nuclear translocation and modulation of CDK4-mediated kinase activity. Can form similar complexes with either CDKN1A or CDKN2A.5 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    CDK14O949215EBI-375013,EBI-1043945
    CDK4P118028EBI-375013,EBI-295644
    CDK6Q005344EBI-375013,EBI-295663
    CDKN1AP389364EBI-375013,EBI-375077
    ICP0P083933EBI-375013,EBI-6148881From a different organism.

    Protein-protein interaction databases

    BioGridi107336. 40 interactions.
    DIPiDIP-31734N.
    IntActiP30281. 26 interactions.
    MINTiMINT-1201666.
    STRINGi9606.ENSP00000362082.

    Structurei

    Secondary structure

    1
    292
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi24 – 3411
    Helixi35 – 384
    Turni45 – 473
    Turni49 – 513
    Helixi54 – 7017
    Helixi77 – 9115
    Helixi96 – 983
    Helixi99 – 11416
    Helixi123 – 1275
    Turni128 – 1303
    Helixi134 – 14714
    Turni148 – 1503
    Helixi157 – 1604
    Helixi161 – 1666
    Turni172 – 1743
    Helixi175 – 19117
    Helixi193 – 1953
    Helixi200 – 21314
    Helixi222 – 23312
    Helixi237 – 25216

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3G33X-ray3.00B/D1-292[»]
    ProteinModelPortaliP30281.
    SMRiP30281. Positions 23-254.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP30281.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini27 – 152126Cyclin N-terminalAdd
    BLAST

    Sequence similaritiesi

    Belongs to the cyclin family. Cyclin D subfamily.Curated
    Contains 1 cyclin N-terminal domain.Curated

    Phylogenomic databases

    eggNOGiCOG5024.
    HOGENOMiHOG000008182.
    HOVERGENiHBG050837.
    InParanoidiP30281.
    KOiK10152.
    OMAiISGETEC.
    OrthoDBiEOG7J447H.
    PhylomeDBiP30281.
    TreeFamiTF101004.

    Family and domain databases

    Gene3Di1.10.472.10. 2 hits.
    InterProiIPR013763. Cyclin-like.
    IPR014400. Cyclin_A/B/D/E/F.
    IPR004367. Cyclin_C-dom.
    IPR015451. Cyclin_D.
    IPR006671. Cyclin_N.
    [Graphical view]
    PANTHERiPTHR10177:SF65. PTHR10177:SF65. 1 hit.
    PfamiPF02984. Cyclin_C. 1 hit.
    PF00134. Cyclin_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001771. Cyclin_A_B_D_E. 1 hit.
    SMARTiSM00385. CYCLIN. 1 hit.
    [Graphical view]
    SUPFAMiSSF47954. SSF47954. 2 hits.
    PROSITEiPS00292. CYCLINS. 1 hit.
    [Graphical view]

    Sequences (4)i

    Sequence statusi: Complete.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P30281-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MELLCCEGTR HAPRAGPDPR LLGDQRVLQS LLRLEERYVP RASYFQCVQR    50
    EIKPHMRKML AYWMLEVCEE QRCEEEVFPL AMNYLDRYLS CVPTRKAQLQ 100
    LLGAVCMLLA SKLRETTPLT IEKLCIYTDH AVSPRQLRDW EVLVLGKLKW 150
    DLAAVIAHDF LAFILHRLSL PRDRQALVKK HAQTFLALCA TDYTFAMYPP 200
    SMIATGSIGA AVQGLGACSM SGDELTELLA GITGTEVDCL RACQEQIEAA 250
    LRESLREASQ TSSSPAPKAP RGSSSQGPSQ TSTPTDVTAI HL 292
    Length:292
    Mass (Da):32,520
    Last modified:May 15, 2002 - v2
    Checksum:i16E7B1604FEB0029
    GO
    Isoform 2 (identifier: P30281-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-81: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:211
    Mass (Da):22,887
    Checksum:iF88EA393BA1B96DB
    GO
    Isoform 3 (identifier: P30281-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         67-138: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:220
    Mass (Da):24,238
    Checksum:i15BC01266FE6BF4B
    GO
    Isoform 4 (identifier: P30281-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-196: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:96
    Mass (Da):9,736
    Checksum:i83F7CF9D0B743ED7
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti134 – 1341P → S.
    Corresponds to variant rs3218089 [ dbSNP | Ensembl ].
    VAR_020412
    Natural varianti253 – 2531E → D.
    Corresponds to variant rs33966734 [ dbSNP | Ensembl ].
    VAR_033726
    Natural varianti259 – 2591S → A.6 Publications
    Corresponds to variant rs1051130 [ dbSNP | Ensembl ].
    VAR_014205

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 196196Missing in isoform 4. 1 PublicationVSP_046266Add
    BLAST
    Alternative sequencei1 – 8181Missing in isoform 2. 1 PublicationVSP_042649Add
    BLAST
    Alternative sequencei67 – 13872Missing in isoform 3. 1 PublicationVSP_046267Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M90814 mRNA. Translation: AAA51927.1.
    M92287 mRNA. Translation: AAA52137.1.
    AF517525 Genomic DNA. Translation: AAM51826.1.
    BX400719 mRNA. No translation available.
    AK057206 mRNA. Translation: BAG51884.1.
    AK097856 mRNA. No translation available.
    AK315421 mRNA. Translation: BAG37810.1.
    CR542246 mRNA. Translation: CAG47042.1.
    AL160163 Genomic DNA. Translation: CAI23491.1.
    AL513008 Genomic DNA. No translation available.
    CH471081 Genomic DNA. Translation: EAX04071.1.
    BC011616 mRNA. Translation: AAH11616.1.
    M88087
    , M88084, M88085, M88086 Genomic DNA. Translation: AAA51929.1.
    CCDSiCCDS47425.1. [P30281-3]
    CCDS47426.1. [P30281-2]
    CCDS47427.1. [P30281-4]
    CCDS4863.1. [P30281-1]
    PIRiB42822.
    RefSeqiNP_001129489.1. NM_001136017.3. [P30281-2]
    NP_001129597.1. NM_001136125.2. [P30281-3]
    NP_001129598.1. NM_001136126.2. [P30281-4]
    NP_001274356.1. NM_001287427.1.
    NP_001274363.1. NM_001287434.1. [P30281-4]
    NP_001751.1. NM_001760.4. [P30281-1]
    UniGeneiHs.534307.

    Genome annotation databases

    EnsembliENST00000372988; ENSP00000362079; ENSG00000112576. [P30281-2]
    ENST00000372991; ENSP00000362082; ENSG00000112576. [P30281-1]
    ENST00000414200; ENSP00000397545; ENSG00000112576. [P30281-3]
    ENST00000415497; ENSP00000401595; ENSG00000112576. [P30281-4]
    ENST00000511642; ENSP00000426212; ENSG00000112576. [P30281-2]
    GeneIDi896.
    KEGGihsa:896.
    UCSCiuc003orn.3. human. [P30281-1]

    Polymorphism databases

    DMDMi20981685.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Web resourcesi

    NIEHS-SNPs

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M90814 mRNA. Translation: AAA51927.1 .
    M92287 mRNA. Translation: AAA52137.1 .
    AF517525 Genomic DNA. Translation: AAM51826.1 .
    BX400719 mRNA. No translation available.
    AK057206 mRNA. Translation: BAG51884.1 .
    AK097856 mRNA. No translation available.
    AK315421 mRNA. Translation: BAG37810.1 .
    CR542246 mRNA. Translation: CAG47042.1 .
    AL160163 Genomic DNA. Translation: CAI23491.1 .
    AL513008 Genomic DNA. No translation available.
    CH471081 Genomic DNA. Translation: EAX04071.1 .
    BC011616 mRNA. Translation: AAH11616.1 .
    M88087
    , M88084 , M88085 , M88086 Genomic DNA. Translation: AAA51929.1 .
    CCDSi CCDS47425.1. [P30281-3 ]
    CCDS47426.1. [P30281-2 ]
    CCDS47427.1. [P30281-4 ]
    CCDS4863.1. [P30281-1 ]
    PIRi B42822.
    RefSeqi NP_001129489.1. NM_001136017.3. [P30281-2 ]
    NP_001129597.1. NM_001136125.2. [P30281-3 ]
    NP_001129598.1. NM_001136126.2. [P30281-4 ]
    NP_001274356.1. NM_001287427.1.
    NP_001274363.1. NM_001287434.1. [P30281-4 ]
    NP_001751.1. NM_001760.4. [P30281-1 ]
    UniGenei Hs.534307.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3G33 X-ray 3.00 B/D 1-292 [» ]
    ProteinModelPortali P30281.
    SMRi P30281. Positions 23-254.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 107336. 40 interactions.
    DIPi DIP-31734N.
    IntActi P30281. 26 interactions.
    MINTi MINT-1201666.
    STRINGi 9606.ENSP00000362082.

    Chemistry

    BindingDBi P30281.
    ChEMBLi CHEMBL2422.

    PTM databases

    PhosphoSitei P30281.

    Polymorphism databases

    DMDMi 20981685.

    Proteomic databases

    MaxQBi P30281.
    PaxDbi P30281.
    PRIDEi P30281.

    Protocols and materials databases

    DNASUi 896.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000372988 ; ENSP00000362079 ; ENSG00000112576 . [P30281-2 ]
    ENST00000372991 ; ENSP00000362082 ; ENSG00000112576 . [P30281-1 ]
    ENST00000414200 ; ENSP00000397545 ; ENSG00000112576 . [P30281-3 ]
    ENST00000415497 ; ENSP00000401595 ; ENSG00000112576 . [P30281-4 ]
    ENST00000511642 ; ENSP00000426212 ; ENSG00000112576 . [P30281-2 ]
    GeneIDi 896.
    KEGGi hsa:896.
    UCSCi uc003orn.3. human. [P30281-1 ]

    Organism-specific databases

    CTDi 896.
    GeneCardsi GC06M041949.
    HGNCi HGNC:1585. CCND3.
    HPAi CAB000116.
    MIMi 123834. gene.
    neXtProti NX_P30281.
    PharmGKBi PA26152.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5024.
    HOGENOMi HOG000008182.
    HOVERGENi HBG050837.
    InParanoidi P30281.
    KOi K10152.
    OMAi ISGETEC.
    OrthoDBi EOG7J447H.
    PhylomeDBi P30281.
    TreeFami TF101004.

    Enzyme and pathway databases

    Reactomei REACT_27161. Transcriptional regulation of white adipocyte differentiation.
    REACT_821. Cyclin D associated events in G1.
    SignaLinki P30281.

    Miscellaneous databases

    ChiTaRSi CCND3. human.
    EvolutionaryTracei P30281.
    GeneWikii Cyclin_D3.
    GenomeRNAii 896.
    NextBioi 3702.
    PROi P30281.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P30281.
    Bgeei P30281.
    CleanExi HS_CCND3.
    Genevestigatori P30281.

    Family and domain databases

    Gene3Di 1.10.472.10. 2 hits.
    InterProi IPR013763. Cyclin-like.
    IPR014400. Cyclin_A/B/D/E/F.
    IPR004367. Cyclin_C-dom.
    IPR015451. Cyclin_D.
    IPR006671. Cyclin_N.
    [Graphical view ]
    PANTHERi PTHR10177:SF65. PTHR10177:SF65. 1 hit.
    Pfami PF02984. Cyclin_C. 1 hit.
    PF00134. Cyclin_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001771. Cyclin_A_B_D_E. 1 hit.
    SMARTi SM00385. CYCLIN. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47954. SSF47954. 2 hits.
    PROSITEi PS00292. CYCLINS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and chromosomal mapping of CCND genes encoding human D-type cyclins."
      Xiong Y., Menninger J., Beach D., Ward D.C.
      Genomics 13:575-584(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT ALA-259.
    2. "Cloning and characterization of human cyclin D3, a cDNA closely related in sequence to the PRAD1/cyclin D1 proto-oncogene."
      Motokura T., Keyomarsi K., Kronenberg H.M., Arnold A.
      J. Biol. Chem. 267:20412-20415(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    3. NIEHS SNPs program
      Submitted (JUN-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT ALA-259.
    4. "Full-length cDNA libraries and normalization."
      Li W.B., Gruber C., Jessee J., Polayes D.
      Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), VARIANT ALA-259.
      Tissue: Cervix carcinoma.
    5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 4), VARIANT ALA-259.
      Tissue: Synovium, Thymus and Umbilical cord blood.
    6. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ALA-259.
    7. "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
      Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ALA-259.
    9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Lung.
    10. "Genomic organization, chromosomal localization, and independent expression of human cyclin D genes."
      Inaba T., Matsushime H., Valentine M., Roussel M.F., Sherr C.J., Look A.T.
      Genomics 13:565-574(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 52-237.
      Tissue: Placenta.
    11. Cited for: INTERACTION WITH CDK4 AND CDKN1A.
    12. "Cyclin D3 interacts with human activating transcription factor 5 and potentiates its transcription activity."
      Liu W., Sun M., Jiang J., Shen X., Sun Q., Liu W., Shen H., Gu J.
      Biochem. Biophys. Res. Commun. 321:954-960(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH ATF5, FUNCTION, SUBCELLULAR LOCATION.
    13. "Identification of the p28 subunit of eukaryotic initiation factor 3(eIF3k) as a new interaction partner of cyclin D3."
      Shen X., Yang Y., Liu W., Sun M., Jiang J., Zong H., Gu J.
      FEBS Lett. 573:139-146(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH EIF3K.
    14. "Regulated activating Thr172 phosphorylation of cyclin-dependent kinase 4(CDK4): its relationship with cyclins and CDK 'inhibitors'."
      Bockstaele L., Kooken H., Libert F., Paternot S., Dumont J.E., de Launoit Y., Roger P.P., Coulonval K.
      Mol. Cell. Biol. 26:5070-5085(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH CDK4; CDKN2A AND CDKN1B.
    15. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    16. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-279, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    17. "F-box protein FBXL2 exerts human lung tumor suppressor-like activity by ubiquitin-mediated degradation of cyclin D3 resulting in cell cycle arrest."
      Chen B.B., Glasser J.R., Coon T.A., Mallampalli R.K.
      Oncogene 31:2566-2579(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: UBIQUITINATION BY SCF(FBXL2).
    18. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    19. "The structure of CDK4/cyclin D3 has implications for models of CDK activation."
      Takaki T., Echalier A., Brown N.R., Hunt T., Endicott J.A., Noble M.E.
      Proc. Natl. Acad. Sci. U.S.A. 106:4171-4176(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) IN COMPLEX WITH CDK4.

    Entry informationi

    Entry nameiCCND3_HUMAN
    AccessioniPrimary (citable) accession number: P30281
    Secondary accession number(s): B2RD63
    , B3KQ22, E9PAS4, E9PB36, Q5T8J0, Q6FG62, Q96F49
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 1, 1993
    Last sequence update: May 15, 2002
    Last modified: October 1, 2014
    This is version 153 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3