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P30281

- CCND3_HUMAN

UniProt

P30281 - CCND3_HUMAN

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Protein

G1/S-specific cyclin-D3

Gene

CCND3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Regulatory component of the cyclin D3-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G1/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G1 phase. Hypophosphorylates RB1 in early G1 phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D3/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex.1 Publication

GO - Molecular functioni

  1. cyclin-dependent protein serine/threonine kinase activity Source: Ensembl
  2. protein kinase binding Source: BHF-UCL

GO - Biological processi

  1. cell cycle Source: UniProtKB-KW
  2. cell division Source: UniProtKB-KW
  3. positive regulation of cyclin-dependent protein serine/threonine kinase activity Source: BHF-UCL
  4. positive regulation of protein phosphorylation Source: BHF-UCL
  5. signal transduction Source: Ensembl
  6. T cell proliferation Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Cyclin

Keywords - Biological processi

Cell cycle, Cell division

Enzyme and pathway databases

ReactomeiREACT_27161. Transcriptional regulation of white adipocyte differentiation.
REACT_821. Cyclin D associated events in G1.
SignaLinkiP30281.

Names & Taxonomyi

Protein namesi
Recommended name:
G1/S-specific cyclin-D3
Gene namesi
Name:CCND3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 6

Organism-specific databases

HGNCiHGNC:1585. CCND3.

Subcellular locationi

Nucleus 1 Publication. Cytoplasm 1 Publication. Membrane 1 Publication
Note: Cyclin D-CDK4 complexes accumulate at the nuclear membrane and are then translocated to the nucleus through interaction with KIP/CIP family members.By similarity

GO - Cellular componenti

  1. cyclin-dependent protein kinase holoenzyme complex Source: BHF-UCL
  2. cytoplasm Source: UniProtKB-KW
  3. membrane Source: UniProtKB-KW
  4. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26152.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 292292G1/S-specific cyclin-D3PRO_0000080442Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei279 – 2791Phosphoserine1 Publication

Post-translational modificationi

Polyubiquitinated by the SCF(FBXL2) complex, leading to proteasomal degradation.1 Publication

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiP30281.
PaxDbiP30281.
PRIDEiP30281.

PTM databases

PhosphoSiteiP30281.

Expressioni

Gene expression databases

BgeeiP30281.
CleanExiHS_CCND3.
ExpressionAtlasiP30281. baseline and differential.
GenevestigatoriP30281.

Organism-specific databases

HPAiCAB000116.

Interactioni

Subunit structurei

Interacts with the CDK4 and CDK6 protein kinases to form a serine/threonine kinase holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex. Interacts with ATF5. Interacts with EIF3K. Component of the ternary complex cyclin D/CDK4/CDKN1B required for nuclear translocation and modulation of CDK4-mediated kinase activity. Can form similar complexes with either CDKN1A or CDKN2A.5 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
CDK14O949215EBI-375013,EBI-1043945
CDK4P118028EBI-375013,EBI-295644
CDK6Q005344EBI-375013,EBI-295663
CDKN1AP389364EBI-375013,EBI-375077
ICP0P083933EBI-375013,EBI-6148881From a different organism.

Protein-protein interaction databases

BioGridi107336. 47 interactions.
DIPiDIP-31734N.
IntActiP30281. 26 interactions.
MINTiMINT-1201666.
STRINGi9606.ENSP00000362082.

Structurei

Secondary structure

1
292
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi24 – 3411Combined sources
Helixi35 – 384Combined sources
Turni45 – 473Combined sources
Turni49 – 513Combined sources
Helixi54 – 7017Combined sources
Helixi77 – 9115Combined sources
Helixi96 – 983Combined sources
Helixi99 – 11416Combined sources
Helixi123 – 1275Combined sources
Turni128 – 1303Combined sources
Helixi134 – 14714Combined sources
Turni148 – 1503Combined sources
Helixi157 – 1604Combined sources
Helixi161 – 1666Combined sources
Turni172 – 1743Combined sources
Helixi175 – 19117Combined sources
Helixi193 – 1953Combined sources
Helixi200 – 21314Combined sources
Helixi222 – 23312Combined sources
Helixi237 – 25216Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3G33X-ray3.00B/D1-292[»]
ProteinModelPortaliP30281.
SMRiP30281. Positions 23-254.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP30281.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini27 – 152126Cyclin N-terminalAdd
BLAST

Sequence similaritiesi

Belongs to the cyclin family. Cyclin D subfamily.Curated
Contains 1 cyclin N-terminal domain.Curated

Phylogenomic databases

eggNOGiCOG5024.
GeneTreeiENSGT00760000118939.
HOGENOMiHOG000008182.
HOVERGENiHBG050837.
InParanoidiP30281.
KOiK10152.
OMAiISGETEC.
OrthoDBiEOG7J447H.
PhylomeDBiP30281.
TreeFamiTF101004.

Family and domain databases

Gene3Di1.10.472.10. 2 hits.
InterProiIPR013763. Cyclin-like.
IPR014400. Cyclin_A/B/D/E/F.
IPR004367. Cyclin_C-dom.
IPR015451. Cyclin_D.
IPR006671. Cyclin_N.
[Graphical view]
PANTHERiPTHR10177:SF65. PTHR10177:SF65. 1 hit.
PfamiPF02984. Cyclin_C. 1 hit.
PF00134. Cyclin_N. 1 hit.
[Graphical view]
PIRSFiPIRSF001771. Cyclin_A_B_D_E. 1 hit.
SMARTiSM00385. CYCLIN. 1 hit.
[Graphical view]
SUPFAMiSSF47954. SSF47954. 2 hits.
PROSITEiPS00292. CYCLINS. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P30281-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MELLCCEGTR HAPRAGPDPR LLGDQRVLQS LLRLEERYVP RASYFQCVQR
60 70 80 90 100
EIKPHMRKML AYWMLEVCEE QRCEEEVFPL AMNYLDRYLS CVPTRKAQLQ
110 120 130 140 150
LLGAVCMLLA SKLRETTPLT IEKLCIYTDH AVSPRQLRDW EVLVLGKLKW
160 170 180 190 200
DLAAVIAHDF LAFILHRLSL PRDRQALVKK HAQTFLALCA TDYTFAMYPP
210 220 230 240 250
SMIATGSIGA AVQGLGACSM SGDELTELLA GITGTEVDCL RACQEQIEAA
260 270 280 290
LRESLREASQ TSSSPAPKAP RGSSSQGPSQ TSTPTDVTAI HL
Length:292
Mass (Da):32,520
Last modified:May 15, 2002 - v2
Checksum:i16E7B1604FEB0029
GO
Isoform 2 (identifier: P30281-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-81: Missing.

Note: No experimental confirmation available.

Show »
Length:211
Mass (Da):22,887
Checksum:iF88EA393BA1B96DB
GO
Isoform 3 (identifier: P30281-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     67-138: Missing.

Note: No experimental confirmation available.

Show »
Length:220
Mass (Da):24,238
Checksum:i15BC01266FE6BF4B
GO
Isoform 4 (identifier: P30281-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-196: Missing.

Note: No experimental confirmation available.

Show »
Length:96
Mass (Da):9,736
Checksum:i83F7CF9D0B743ED7
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti134 – 1341P → S.
Corresponds to variant rs3218089 [ dbSNP | Ensembl ].
VAR_020412
Natural varianti253 – 2531E → D.
Corresponds to variant rs33966734 [ dbSNP | Ensembl ].
VAR_033726
Natural varianti259 – 2591S → A.6 Publications
Corresponds to variant rs1051130 [ dbSNP | Ensembl ].
VAR_014205

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 196196Missing in isoform 4. 1 PublicationVSP_046266Add
BLAST
Alternative sequencei1 – 8181Missing in isoform 2. 1 PublicationVSP_042649Add
BLAST
Alternative sequencei67 – 13872Missing in isoform 3. 1 PublicationVSP_046267Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M90814 mRNA. Translation: AAA51927.1.
M92287 mRNA. Translation: AAA52137.1.
AF517525 Genomic DNA. Translation: AAM51826.1.
BX400719 mRNA. No translation available.
AK057206 mRNA. Translation: BAG51884.1.
AK097856 mRNA. No translation available.
AK315421 mRNA. Translation: BAG37810.1.
CR542246 mRNA. Translation: CAG47042.1.
AL160163 Genomic DNA. Translation: CAI23491.1.
AL513008 Genomic DNA. No translation available.
CH471081 Genomic DNA. Translation: EAX04071.1.
BC011616 mRNA. Translation: AAH11616.1.
M88087
, M88084, M88085, M88086 Genomic DNA. Translation: AAA51929.1.
CCDSiCCDS47425.1. [P30281-3]
CCDS47426.1. [P30281-2]
CCDS47427.1. [P30281-4]
CCDS4863.1. [P30281-1]
PIRiB42822.
RefSeqiNP_001129489.1. NM_001136017.3. [P30281-2]
NP_001129597.1. NM_001136125.2. [P30281-3]
NP_001129598.1. NM_001136126.2. [P30281-4]
NP_001274356.1. NM_001287427.1.
NP_001274363.1. NM_001287434.1. [P30281-4]
NP_001751.1. NM_001760.4. [P30281-1]
UniGeneiHs.534307.

Genome annotation databases

EnsembliENST00000372988; ENSP00000362079; ENSG00000112576. [P30281-2]
ENST00000372991; ENSP00000362082; ENSG00000112576. [P30281-1]
ENST00000414200; ENSP00000397545; ENSG00000112576. [P30281-3]
ENST00000415497; ENSP00000401595; ENSG00000112576. [P30281-4]
ENST00000511642; ENSP00000426212; ENSG00000112576. [P30281-2]
ENST00000616010; ENSP00000484424; ENSG00000112576. [P30281-4]
GeneIDi896.
KEGGihsa:896.
UCSCiuc003orn.3. human. [P30281-1]

Polymorphism databases

DMDMi20981685.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M90814 mRNA. Translation: AAA51927.1 .
M92287 mRNA. Translation: AAA52137.1 .
AF517525 Genomic DNA. Translation: AAM51826.1 .
BX400719 mRNA. No translation available.
AK057206 mRNA. Translation: BAG51884.1 .
AK097856 mRNA. No translation available.
AK315421 mRNA. Translation: BAG37810.1 .
CR542246 mRNA. Translation: CAG47042.1 .
AL160163 Genomic DNA. Translation: CAI23491.1 .
AL513008 Genomic DNA. No translation available.
CH471081 Genomic DNA. Translation: EAX04071.1 .
BC011616 mRNA. Translation: AAH11616.1 .
M88087
, M88084 , M88085 , M88086 Genomic DNA. Translation: AAA51929.1 .
CCDSi CCDS47425.1. [P30281-3 ]
CCDS47426.1. [P30281-2 ]
CCDS47427.1. [P30281-4 ]
CCDS4863.1. [P30281-1 ]
PIRi B42822.
RefSeqi NP_001129489.1. NM_001136017.3. [P30281-2 ]
NP_001129597.1. NM_001136125.2. [P30281-3 ]
NP_001129598.1. NM_001136126.2. [P30281-4 ]
NP_001274356.1. NM_001287427.1.
NP_001274363.1. NM_001287434.1. [P30281-4 ]
NP_001751.1. NM_001760.4. [P30281-1 ]
UniGenei Hs.534307.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3G33 X-ray 3.00 B/D 1-292 [» ]
ProteinModelPortali P30281.
SMRi P30281. Positions 23-254.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 107336. 47 interactions.
DIPi DIP-31734N.
IntActi P30281. 26 interactions.
MINTi MINT-1201666.
STRINGi 9606.ENSP00000362082.

Chemistry

BindingDBi P30281.
ChEMBLi CHEMBL2111448.

PTM databases

PhosphoSitei P30281.

Polymorphism databases

DMDMi 20981685.

Proteomic databases

MaxQBi P30281.
PaxDbi P30281.
PRIDEi P30281.

Protocols and materials databases

DNASUi 896.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000372988 ; ENSP00000362079 ; ENSG00000112576 . [P30281-2 ]
ENST00000372991 ; ENSP00000362082 ; ENSG00000112576 . [P30281-1 ]
ENST00000414200 ; ENSP00000397545 ; ENSG00000112576 . [P30281-3 ]
ENST00000415497 ; ENSP00000401595 ; ENSG00000112576 . [P30281-4 ]
ENST00000511642 ; ENSP00000426212 ; ENSG00000112576 . [P30281-2 ]
ENST00000616010 ; ENSP00000484424 ; ENSG00000112576 . [P30281-4 ]
GeneIDi 896.
KEGGi hsa:896.
UCSCi uc003orn.3. human. [P30281-1 ]

Organism-specific databases

CTDi 896.
GeneCardsi GC06M041949.
HGNCi HGNC:1585. CCND3.
HPAi CAB000116.
MIMi 123834. gene.
neXtProti NX_P30281.
PharmGKBi PA26152.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5024.
GeneTreei ENSGT00760000118939.
HOGENOMi HOG000008182.
HOVERGENi HBG050837.
InParanoidi P30281.
KOi K10152.
OMAi ISGETEC.
OrthoDBi EOG7J447H.
PhylomeDBi P30281.
TreeFami TF101004.

Enzyme and pathway databases

Reactomei REACT_27161. Transcriptional regulation of white adipocyte differentiation.
REACT_821. Cyclin D associated events in G1.
SignaLinki P30281.

Miscellaneous databases

ChiTaRSi CCND3. human.
EvolutionaryTracei P30281.
GeneWikii Cyclin_D3.
GenomeRNAii 896.
NextBioi 3702.
PROi P30281.
SOURCEi Search...

Gene expression databases

Bgeei P30281.
CleanExi HS_CCND3.
ExpressionAtlasi P30281. baseline and differential.
Genevestigatori P30281.

Family and domain databases

Gene3Di 1.10.472.10. 2 hits.
InterProi IPR013763. Cyclin-like.
IPR014400. Cyclin_A/B/D/E/F.
IPR004367. Cyclin_C-dom.
IPR015451. Cyclin_D.
IPR006671. Cyclin_N.
[Graphical view ]
PANTHERi PTHR10177:SF65. PTHR10177:SF65. 1 hit.
Pfami PF02984. Cyclin_C. 1 hit.
PF00134. Cyclin_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF001771. Cyclin_A_B_D_E. 1 hit.
SMARTi SM00385. CYCLIN. 1 hit.
[Graphical view ]
SUPFAMi SSF47954. SSF47954. 2 hits.
PROSITEi PS00292. CYCLINS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and chromosomal mapping of CCND genes encoding human D-type cyclins."
    Xiong Y., Menninger J., Beach D., Ward D.C.
    Genomics 13:575-584(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT ALA-259.
  2. "Cloning and characterization of human cyclin D3, a cDNA closely related in sequence to the PRAD1/cyclin D1 proto-oncogene."
    Motokura T., Keyomarsi K., Kronenberg H.M., Arnold A.
    J. Biol. Chem. 267:20412-20415(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  3. NIEHS SNPs program
    Submitted (JUN-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT ALA-259.
  4. "Full-length cDNA libraries and normalization."
    Li W.B., Gruber C., Jessee J., Polayes D.
    Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), VARIANT ALA-259.
    Tissue: Cervix carcinoma.
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 4), VARIANT ALA-259.
    Tissue: Synovium, Thymus and Umbilical cord blood.
  6. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ALA-259.
  7. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ALA-259.
  9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Lung.
  10. "Genomic organization, chromosomal localization, and independent expression of human cyclin D genes."
    Inaba T., Matsushime H., Valentine M., Roussel M.F., Sherr C.J., Look A.T.
    Genomics 13:565-574(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 52-237.
    Tissue: Placenta.
  11. Cited for: INTERACTION WITH CDK4 AND CDKN1A.
  12. "Cyclin D3 interacts with human activating transcription factor 5 and potentiates its transcription activity."
    Liu W., Sun M., Jiang J., Shen X., Sun Q., Liu W., Shen H., Gu J.
    Biochem. Biophys. Res. Commun. 321:954-960(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH ATF5, FUNCTION, SUBCELLULAR LOCATION.
  13. "Identification of the p28 subunit of eukaryotic initiation factor 3(eIF3k) as a new interaction partner of cyclin D3."
    Shen X., Yang Y., Liu W., Sun M., Jiang J., Zong H., Gu J.
    FEBS Lett. 573:139-146(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH EIF3K.
  14. "Regulated activating Thr172 phosphorylation of cyclin-dependent kinase 4(CDK4): its relationship with cyclins and CDK 'inhibitors'."
    Bockstaele L., Kooken H., Libert F., Paternot S., Dumont J.E., de Launoit Y., Roger P.P., Coulonval K.
    Mol. Cell. Biol. 26:5070-5085(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH CDK4; CDKN2A AND CDKN1B.
  15. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  16. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-279, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  17. "F-box protein FBXL2 exerts human lung tumor suppressor-like activity by ubiquitin-mediated degradation of cyclin D3 resulting in cell cycle arrest."
    Chen B.B., Glasser J.R., Coon T.A., Mallampalli R.K.
    Oncogene 31:2566-2579(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: UBIQUITINATION BY SCF(FBXL2).
  18. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  19. "The structure of CDK4/cyclin D3 has implications for models of CDK activation."
    Takaki T., Echalier A., Brown N.R., Hunt T., Endicott J.A., Noble M.E.
    Proc. Natl. Acad. Sci. U.S.A. 106:4171-4176(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) IN COMPLEX WITH CDK4.

Entry informationi

Entry nameiCCND3_HUMAN
AccessioniPrimary (citable) accession number: P30281
Secondary accession number(s): B2RD63
, B3KQ22, E9PAS4, E9PB36, Q5T8J0, Q6FG62, Q96F49
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: May 15, 2002
Last modified: November 26, 2014
This is version 155 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

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