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P30280

- CCND2_MOUSE

UniProt

P30280 - CCND2_MOUSE

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Protein

G1/S-specific cyclin-D2

Gene

Ccnd2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G1/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G1 phase. Hypophosphorylates RB1 in early G1 phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D2/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex By similarity.By similarity

GO - Biological processi

  1. cell cycle Source: UniProtKB-KW
  2. cell division Source: UniProtKB-KW
  3. positive regulation of cyclin-dependent protein serine/threonine kinase activity Source: Ensembl
  4. regulation of cell cycle Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Cyclin

Keywords - Biological processi

Cell cycle, Cell division

Names & Taxonomyi

Protein namesi
Recommended name:
G1/S-specific cyclin-D2
Gene namesi
Name:Ccnd2
Synonyms:Cyl-2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 6

Organism-specific databases

MGIiMGI:88314. Ccnd2.

Subcellular locationi

Nucleus By similarity. Cytoplasm By similarity. Membrane By similarity
Note: Cyclin D-CDK4 complexes accumulate at the nuclear membrane and are then translocated into the nucleus through interaction with KIP/CIP family members.By similarity

GO - Cellular componenti

  1. chromatin Source: Ensembl
  2. cyclin-dependent protein kinase holoenzyme complex Source: Ensembl
  3. cytosol Source: Ensembl
  4. nuclear membrane Source: Ensembl
  5. nucleolus Source: Ensembl
  6. nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 289289G1/S-specific cyclin-D2PRO_0000080438Add
BLAST

Post-translational modificationi

Polyubiquitinated by the SCF(FBXL2) complex, leading to proteasomal degradation.By similarity

Keywords - PTMi

Ubl conjugation

Proteomic databases

MaxQBiP30280.
PRIDEiP30280.

PTM databases

PhosphoSiteiP30280.

Expressioni

Gene expression databases

BgeeiP30280.
CleanExiMM_CCND2.
ExpressionAtlasiP30280. baseline and differential.
GenevestigatoriP30280.

Interactioni

Subunit structurei

Interacts with either CDK4 or CDK6 protein kinase to form a serine/threonine kinase holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex. Component of the ternary complex cyclin D/CDK4/CDKN1B required for nuclear translocation and modulation of CDK4-mediated kinase activity By similarity.By similarity

Protein-protein interaction databases

BioGridi198549. 5 interactions.
DIPiDIP-24177N.
IntActiP30280. 3 interactions.
STRINGi10090.ENSMUSP00000000188.

Structurei

3D structure databases

ProteinModelPortaliP30280.
SMRiP30280. Positions 22-256.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini26 – 151126Cyclin N-terminalAdd
BLAST

Sequence similaritiesi

Belongs to the cyclin family. Cyclin D subfamily.Curated
Contains 1 cyclin N-terminal domain.Curated

Phylogenomic databases

eggNOGiCOG5024.
HOGENOMiHOG000008182.
HOVERGENiHBG050837.
InParanoidiP30280.
KOiK10151.
OMAiLIRKHVQ.
OrthoDBiEOG7J447H.
PhylomeDBiP30280.
TreeFamiTF101004.

Family and domain databases

Gene3Di1.10.472.10. 2 hits.
InterProiIPR013763. Cyclin-like.
IPR014400. Cyclin_A/B/D/E/F.
IPR004367. Cyclin_C-dom.
IPR015451. Cyclin_D.
IPR006671. Cyclin_N.
[Graphical view]
PANTHERiPTHR10177:SF66. PTHR10177:SF66. 1 hit.
PfamiPF02984. Cyclin_C. 1 hit.
PF00134. Cyclin_N. 1 hit.
[Graphical view]
PIRSFiPIRSF001771. Cyclin_A_B_D_E. 1 hit.
SMARTiSM00385. CYCLIN. 1 hit.
[Graphical view]
SUPFAMiSSF47954. SSF47954. 2 hits.
PROSITEiPS00292. CYCLINS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P30280-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MELLCCEVDP VRRAVPDRNL LEDRVLQNLL TIEERYLPQC SYFKCVQKDI
60 70 80 90 100
QPYMRRMVAT WMLEVCEEQK CEEEVFPLAM NYLDRFLAGV PTPKTHLQLL
110 120 130 140 150
GAVCMFLASK LKETIPLTAE KLCIYTDNSV KPQELLEWEL VVLGKLKWNL
160 170 180 190 200
AAVTPHDFIE HILRKLPQQK EKLSLIRKHA QTFIALCATD FKFAMYPPSM
210 220 230 240 250
IATGSVGAAI CGLQQDDEVN TLTCDALTEL LAKITHTDVD CLKACQEQIE
260 270 280
ALLLNSLQQF RQEQHNAGSK SVEDPDQATT PTDVRDVDL
Length:289
Mass (Da):32,897
Last modified:April 1, 1993 - v1
Checksum:i58F322771DD1DA3D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M83749 mRNA. Translation: AAA37519.1.
M86182 mRNA. Translation: AAA37503.1.
BC049086 mRNA. Translation: AAH49086.1.
CCDSiCCDS20564.1.
PIRiA41984.
RefSeqiNP_033959.1. NM_009829.3.
XP_006505522.1. XM_006505459.1.
XP_006505523.1. XM_006505460.1.
UniGeneiMm.333406.

Genome annotation databases

EnsembliENSMUST00000000188; ENSMUSP00000000188; ENSMUSG00000000184.
GeneIDi12444.
KEGGimmu:12444.
UCSCiuc009dvr.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M83749 mRNA. Translation: AAA37519.1 .
M86182 mRNA. Translation: AAA37503.1 .
BC049086 mRNA. Translation: AAH49086.1 .
CCDSi CCDS20564.1.
PIRi A41984.
RefSeqi NP_033959.1. NM_009829.3.
XP_006505522.1. XM_006505459.1.
XP_006505523.1. XM_006505460.1.
UniGenei Mm.333406.

3D structure databases

ProteinModelPortali P30280.
SMRi P30280. Positions 22-256.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 198549. 5 interactions.
DIPi DIP-24177N.
IntActi P30280. 3 interactions.
STRINGi 10090.ENSMUSP00000000188.

PTM databases

PhosphoSitei P30280.

Proteomic databases

MaxQBi P30280.
PRIDEi P30280.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000000188 ; ENSMUSP00000000188 ; ENSMUSG00000000184 .
GeneIDi 12444.
KEGGi mmu:12444.
UCSCi uc009dvr.1. mouse.

Organism-specific databases

CTDi 894.
MGIi MGI:88314. Ccnd2.

Phylogenomic databases

eggNOGi COG5024.
HOGENOMi HOG000008182.
HOVERGENi HBG050837.
InParanoidi P30280.
KOi K10151.
OMAi LIRKHVQ.
OrthoDBi EOG7J447H.
PhylomeDBi P30280.
TreeFami TF101004.

Miscellaneous databases

ChiTaRSi CCND2. mouse.
NextBioi 281258.
PROi P30280.
SOURCEi Search...

Gene expression databases

Bgeei P30280.
CleanExi MM_CCND2.
ExpressionAtlasi P30280. baseline and differential.
Genevestigatori P30280.

Family and domain databases

Gene3Di 1.10.472.10. 2 hits.
InterProi IPR013763. Cyclin-like.
IPR014400. Cyclin_A/B/D/E/F.
IPR004367. Cyclin_C-dom.
IPR015451. Cyclin_D.
IPR006671. Cyclin_N.
[Graphical view ]
PANTHERi PTHR10177:SF66. PTHR10177:SF66. 1 hit.
Pfami PF02984. Cyclin_C. 1 hit.
PF00134. Cyclin_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF001771. Cyclin_A_B_D_E. 1 hit.
SMARTi SM00385. CYCLIN. 1 hit.
[Graphical view ]
SUPFAMi SSF47954. SSF47954. 2 hits.
PROSITEi PS00292. CYCLINS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Colony-stimulating factor 1 regulates novel cyclins during the G1 phase of the cell cycle."
    Matsushime H., Roussel M.F., Ashmun R.A., Sherr C.J.
    Cell 65:701-713(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Brain.

Entry informationi

Entry nameiCCND2_MOUSE
AccessioniPrimary (citable) accession number: P30280
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: October 29, 2014
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3