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Protein

G1/S-specific cyclin-D2

Gene

Ccnd2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G1/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G1 phase. Hypophosphorylates RB1 in early G1 phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D2/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • adult locomotory behavior Source: MGI
  • cell cycle Source: UniProtKB-KW
  • cell division Source: UniProtKB-KW
  • cellular response to X-ray Source: MGI
  • long-term memory Source: MGI
  • negative regulation of apoptotic process Source: MGI
  • positive regulation of cell proliferation Source: MGI
  • positive regulation of cyclin-dependent protein serine/threonine kinase activity Source: MGI
  • positive regulation of G1/S transition of mitotic cell cycle Source: MGI
  • positive regulation of protein phosphorylation Source: MGI
  • regulation of cell cycle Source: MGI

Keywordsi

Molecular functionCyclin
Biological processCell cycle, Cell division

Enzyme and pathway databases

ReactomeiR-MMU-69231 Cyclin D associated events in G1
R-MMU-8934593 Regulation of RUNX1 Expression and Activity

Names & Taxonomyi

Protein namesi
Recommended name:
G1/S-specific cyclin-D2
Gene namesi
Name:Ccnd2
Synonyms:Cyl-2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:88314 Ccnd2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000804381 – 289G1/S-specific cyclin-D2Add BLAST289

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei271PhosphoserineBy similarity1
Modified residuei280PhosphothreonineCombined sources1

Post-translational modificationi

Polyubiquitinated by the SCF(FBXL2) complex, leading to proteasomal degradation.By similarity

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP30280
PaxDbiP30280
PeptideAtlasiP30280
PRIDEiP30280

PTM databases

iPTMnetiP30280
PhosphoSitePlusiP30280

Expressioni

Gene expression databases

BgeeiENSMUSG00000000184
CleanExiMM_CCND2
ExpressionAtlasiP30280 baseline and differential
GenevisibleiP30280 MM

Interactioni

Subunit structurei

Interacts with either CDK4 or CDK6 protein kinase to form a serine/threonine kinase holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex. Component of the ternary complex cyclin D/CDK4/CDKN1B required for nuclear translocation and modulation of CDK4-mediated kinase activity (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi198549, 5 interactors
CORUMiP30280
DIPiDIP-24177N
IntActiP30280, 4 interactors
STRINGi10090.ENSMUSP00000000188

Structurei

3D structure databases

ProteinModelPortaliP30280
SMRiP30280
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini26 – 151Cyclin N-terminalAdd BLAST126

Sequence similaritiesi

Belongs to the cyclin family. Cyclin D subfamily.Curated

Phylogenomic databases

eggNOGiKOG0656 Eukaryota
ENOG410XRKC LUCA
GeneTreeiENSGT00910000144111
HOGENOMiHOG000008182
HOVERGENiHBG050837
InParanoidiP30280
KOiK10151
OMAiVVPTKKC
OrthoDBiEOG091G0URX
PhylomeDBiP30280
TreeFamiTF101004

Family and domain databases

CDDicd00043 CYCLIN, 1 hit
InterProiView protein in InterPro
IPR013763 Cyclin-like
IPR036915 Cyclin-like_sf
IPR004367 Cyclin_C-dom
IPR015451 Cyclin_D
IPR006671 Cyclin_N
PANTHERiPTHR10177:SF66 PTHR10177:SF66, 1 hit
PfamiView protein in Pfam
PF02984 Cyclin_C, 1 hit
PF00134 Cyclin_N, 1 hit
SMARTiView protein in SMART
SM00385 CYCLIN, 1 hit
SM01332 Cyclin_C, 1 hit
SUPFAMiSSF47954 SSF47954, 2 hits
PROSITEiView protein in PROSITE
PS00292 CYCLINS, 1 hit

Sequencei

Sequence statusi: Complete.

P30280-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELLCCEVDP VRRAVPDRNL LEDRVLQNLL TIEERYLPQC SYFKCVQKDI
60 70 80 90 100
QPYMRRMVAT WMLEVCEEQK CEEEVFPLAM NYLDRFLAGV PTPKTHLQLL
110 120 130 140 150
GAVCMFLASK LKETIPLTAE KLCIYTDNSV KPQELLEWEL VVLGKLKWNL
160 170 180 190 200
AAVTPHDFIE HILRKLPQQK EKLSLIRKHA QTFIALCATD FKFAMYPPSM
210 220 230 240 250
IATGSVGAAI CGLQQDDEVN TLTCDALTEL LAKITHTDVD CLKACQEQIE
260 270 280
ALLLNSLQQF RQEQHNAGSK SVEDPDQATT PTDVRDVDL
Length:289
Mass (Da):32,897
Last modified:April 1, 1993 - v1
Checksum:i58F322771DD1DA3D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M83749 mRNA Translation: AAA37519.1
M86182 mRNA Translation: AAA37503.1
BC049086 mRNA Translation: AAH49086.1
CCDSiCCDS20564.1
PIRiA41984
RefSeqiNP_033959.1, NM_009829.3
XP_006505522.1, XM_006505459.2
XP_006505523.1, XM_006505460.1
UniGeneiMm.333406

Genome annotation databases

EnsembliENSMUST00000000188; ENSMUSP00000000188; ENSMUSG00000000184
GeneIDi12444
KEGGimmu:12444
UCSCiuc009dvr.1 mouse

Similar proteinsi

Entry informationi

Entry nameiCCND2_MOUSE
AccessioniPrimary (citable) accession number: P30280
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: March 28, 2018
This is version 148 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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