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P30280 (CCND2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 119. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
G1/S-specific cyclin-D2
Gene names
Name:Ccnd2
Synonyms:Cyl-2
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length289 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G1/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G1 phase. Hypophosphorylates RB1 in early G1 phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D2/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex By similarity.

Subunit structure

Interacts with either CDK4 or CDK6 protein kinase to form a serine/threonine kinase holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex. Component of the ternary complex cyclin D/CDK4/CDKN1B required for nuclear translocation and modulation of CDK4-mediated kinase activity By similarity.

Subcellular location

Nucleus By similarity. Cytoplasm By similarity. Membrane By similarity. Note: Cyclin D-CDK4 complexes accumulate at the nuclear membrane and are then translocated into the nucleus through interaction with KIP/CIP family members By similarity.

Post-translational modification

Polyubiquitinated by the SCF(FBXL2) complex, leading to proteasomal degradation By similarity.

Sequence similarities

Belongs to the cyclin family. Cyclin D subfamily.

Contains 1 cyclin N-terminal domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 289289G1/S-specific cyclin-D2
PRO_0000080438

Regions

Domain26 – 151126Cyclin N-terminal

Sequences

Sequence LengthMass (Da)Tools
P30280 [UniParc].

Last modified April 1, 1993. Version 1.
Checksum: 58F322771DD1DA3D

FASTA28932,897
        10         20         30         40         50         60 
MELLCCEVDP VRRAVPDRNL LEDRVLQNLL TIEERYLPQC SYFKCVQKDI QPYMRRMVAT 

        70         80         90        100        110        120 
WMLEVCEEQK CEEEVFPLAM NYLDRFLAGV PTPKTHLQLL GAVCMFLASK LKETIPLTAE 

       130        140        150        160        170        180 
KLCIYTDNSV KPQELLEWEL VVLGKLKWNL AAVTPHDFIE HILRKLPQQK EKLSLIRKHA 

       190        200        210        220        230        240 
QTFIALCATD FKFAMYPPSM IATGSVGAAI CGLQQDDEVN TLTCDALTEL LAKITHTDVD 

       250        260        270        280 
CLKACQEQIE ALLLNSLQQF RQEQHNAGSK SVEDPDQATT PTDVRDVDL 

« Hide

References

« Hide 'large scale' references
[1]"Cloning of a D-type cyclin from murine erythroleukemia cells."
Kiyokawa H., Bousquets X., Powell C.T., Ngo L., Rifkind R.A., Marks P.A.
Proc. Natl. Acad. Sci. U.S.A. 89:2444-2447(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Colony-stimulating factor 1 regulates novel cyclins during the G1 phase of the cell cycle."
Matsushime H., Roussel M.F., Ashmun R.A., Sherr C.J.
Cell 65:701-713(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6.
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M83749 mRNA. Translation: AAA37519.1.
M86182 mRNA. Translation: AAA37503.1.
BC049086 mRNA. Translation: AAH49086.1.
CCDSCCDS20564.1.
PIRA41984.
RefSeqNP_033959.1. NM_009829.3.
XP_006505522.1. XM_006505459.1.
XP_006505523.1. XM_006505460.1.
UniGeneMm.333406.

3D structure databases

ProteinModelPortalP30280.
SMRP30280. Positions 22-256.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid198549. 5 interactions.
DIPDIP-24177N.
IntActP30280. 3 interactions.
STRING10090.ENSMUSP00000000188.

PTM databases

PhosphoSiteP30280.

Proteomic databases

MaxQBP30280.
PRIDEP30280.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000000188; ENSMUSP00000000188; ENSMUSG00000000184.
GeneID12444.
KEGGmmu:12444.
UCSCuc009dvr.1. mouse.

Organism-specific databases

CTD894.
MGIMGI:88314. Ccnd2.

Phylogenomic databases

eggNOGCOG5024.
HOGENOMHOG000008182.
HOVERGENHBG050837.
InParanoidP30280.
KOK10151.
OMALIRKHVQ.
OrthoDBEOG7J447H.
PhylomeDBP30280.
TreeFamTF101004.

Gene expression databases

ArrayExpressP30280.
BgeeP30280.
CleanExMM_CCND2.
GenevestigatorP30280.

Family and domain databases

Gene3D1.10.472.10. 2 hits.
InterProIPR013763. Cyclin-like.
IPR014400. Cyclin_A/B/D/E/F.
IPR004367. Cyclin_C-dom.
IPR015451. Cyclin_D.
IPR006671. Cyclin_N.
[Graphical view]
PANTHERPTHR10177:SF66. PTHR10177:SF66. 1 hit.
PfamPF02984. Cyclin_C. 1 hit.
PF00134. Cyclin_N. 1 hit.
[Graphical view]
PIRSFPIRSF001771. Cyclin_A_B_D_E. 1 hit.
SMARTSM00385. CYCLIN. 1 hit.
[Graphical view]
SUPFAMSSF47954. SSF47954. 2 hits.
PROSITEPS00292. CYCLINS. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSCCND2. mouse.
NextBio281258.
PROP30280.
SOURCESearch...

Entry information

Entry nameCCND2_MOUSE
AccessionPrimary (citable) accession number: P30280
Entry history
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: July 9, 2014
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot