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P30280

- CCND2_MOUSE

UniProt

P30280 - CCND2_MOUSE

Protein

G1/S-specific cyclin-D2

Gene

Ccnd2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 120 (01 Oct 2014)
      Sequence version 1 (01 Apr 1993)
      Previous versions | rss
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    Functioni

    Regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G1/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G1 phase. Hypophosphorylates RB1 in early G1 phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D2/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex By similarity.By similarity

    GO - Molecular functioni

    1. protein binding Source: MGI

    GO - Biological processi

    1. cell cycle Source: UniProtKB-KW
    2. cell division Source: UniProtKB-KW
    3. positive regulation of cyclin-dependent protein serine/threonine kinase activity Source: Ensembl
    4. regulation of cell cycle Source: MGI

    Keywords - Molecular functioni

    Cyclin

    Keywords - Biological processi

    Cell cycle, Cell division

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    G1/S-specific cyclin-D2
    Gene namesi
    Name:Ccnd2
    Synonyms:Cyl-2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 6

    Organism-specific databases

    MGIiMGI:88314. Ccnd2.

    Subcellular locationi

    Nucleus By similarity. Cytoplasm By similarity. Membrane By similarity
    Note: Cyclin D-CDK4 complexes accumulate at the nuclear membrane and are then translocated into the nucleus through interaction with KIP/CIP family members.By similarity

    GO - Cellular componenti

    1. chromatin Source: Ensembl
    2. cyclin-dependent protein kinase holoenzyme complex Source: Ensembl
    3. cytosol Source: Ensembl
    4. nuclear membrane Source: Ensembl
    5. nucleolus Source: Ensembl
    6. nucleus Source: MGI

    Keywords - Cellular componenti

    Cytoplasm, Membrane, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 289289G1/S-specific cyclin-D2PRO_0000080438Add
    BLAST

    Post-translational modificationi

    Polyubiquitinated by the SCF(FBXL2) complex, leading to proteasomal degradation.By similarity

    Keywords - PTMi

    Ubl conjugation

    Proteomic databases

    MaxQBiP30280.
    PRIDEiP30280.

    PTM databases

    PhosphoSiteiP30280.

    Expressioni

    Gene expression databases

    ArrayExpressiP30280.
    BgeeiP30280.
    CleanExiMM_CCND2.
    GenevestigatoriP30280.

    Interactioni

    Subunit structurei

    Interacts with either CDK4 or CDK6 protein kinase to form a serine/threonine kinase holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex. Component of the ternary complex cyclin D/CDK4/CDKN1B required for nuclear translocation and modulation of CDK4-mediated kinase activity By similarity.By similarity

    Protein-protein interaction databases

    BioGridi198549. 5 interactions.
    DIPiDIP-24177N.
    IntActiP30280. 3 interactions.
    STRINGi10090.ENSMUSP00000000188.

    Structurei

    3D structure databases

    ProteinModelPortaliP30280.
    SMRiP30280. Positions 22-256.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini26 – 151126Cyclin N-terminalAdd
    BLAST

    Sequence similaritiesi

    Belongs to the cyclin family. Cyclin D subfamily.Curated
    Contains 1 cyclin N-terminal domain.Curated

    Phylogenomic databases

    eggNOGiCOG5024.
    HOGENOMiHOG000008182.
    HOVERGENiHBG050837.
    InParanoidiP30280.
    KOiK10151.
    OMAiLIRKHVQ.
    OrthoDBiEOG7J447H.
    PhylomeDBiP30280.
    TreeFamiTF101004.

    Family and domain databases

    Gene3Di1.10.472.10. 2 hits.
    InterProiIPR013763. Cyclin-like.
    IPR014400. Cyclin_A/B/D/E/F.
    IPR004367. Cyclin_C-dom.
    IPR015451. Cyclin_D.
    IPR006671. Cyclin_N.
    [Graphical view]
    PANTHERiPTHR10177:SF66. PTHR10177:SF66. 1 hit.
    PfamiPF02984. Cyclin_C. 1 hit.
    PF00134. Cyclin_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001771. Cyclin_A_B_D_E. 1 hit.
    SMARTiSM00385. CYCLIN. 1 hit.
    [Graphical view]
    SUPFAMiSSF47954. SSF47954. 2 hits.
    PROSITEiPS00292. CYCLINS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P30280-1 [UniParc]FASTAAdd to Basket

    « Hide

    MELLCCEVDP VRRAVPDRNL LEDRVLQNLL TIEERYLPQC SYFKCVQKDI    50
    QPYMRRMVAT WMLEVCEEQK CEEEVFPLAM NYLDRFLAGV PTPKTHLQLL 100
    GAVCMFLASK LKETIPLTAE KLCIYTDNSV KPQELLEWEL VVLGKLKWNL 150
    AAVTPHDFIE HILRKLPQQK EKLSLIRKHA QTFIALCATD FKFAMYPPSM 200
    IATGSVGAAI CGLQQDDEVN TLTCDALTEL LAKITHTDVD CLKACQEQIE 250
    ALLLNSLQQF RQEQHNAGSK SVEDPDQATT PTDVRDVDL 289
    Length:289
    Mass (Da):32,897
    Last modified:April 1, 1993 - v1
    Checksum:i58F322771DD1DA3D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M83749 mRNA. Translation: AAA37519.1.
    M86182 mRNA. Translation: AAA37503.1.
    BC049086 mRNA. Translation: AAH49086.1.
    CCDSiCCDS20564.1.
    PIRiA41984.
    RefSeqiNP_033959.1. NM_009829.3.
    XP_006505522.1. XM_006505459.1.
    XP_006505523.1. XM_006505460.1.
    UniGeneiMm.333406.

    Genome annotation databases

    EnsembliENSMUST00000000188; ENSMUSP00000000188; ENSMUSG00000000184.
    GeneIDi12444.
    KEGGimmu:12444.
    UCSCiuc009dvr.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M83749 mRNA. Translation: AAA37519.1 .
    M86182 mRNA. Translation: AAA37503.1 .
    BC049086 mRNA. Translation: AAH49086.1 .
    CCDSi CCDS20564.1.
    PIRi A41984.
    RefSeqi NP_033959.1. NM_009829.3.
    XP_006505522.1. XM_006505459.1.
    XP_006505523.1. XM_006505460.1.
    UniGenei Mm.333406.

    3D structure databases

    ProteinModelPortali P30280.
    SMRi P30280. Positions 22-256.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 198549. 5 interactions.
    DIPi DIP-24177N.
    IntActi P30280. 3 interactions.
    STRINGi 10090.ENSMUSP00000000188.

    PTM databases

    PhosphoSitei P30280.

    Proteomic databases

    MaxQBi P30280.
    PRIDEi P30280.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000000188 ; ENSMUSP00000000188 ; ENSMUSG00000000184 .
    GeneIDi 12444.
    KEGGi mmu:12444.
    UCSCi uc009dvr.1. mouse.

    Organism-specific databases

    CTDi 894.
    MGIi MGI:88314. Ccnd2.

    Phylogenomic databases

    eggNOGi COG5024.
    HOGENOMi HOG000008182.
    HOVERGENi HBG050837.
    InParanoidi P30280.
    KOi K10151.
    OMAi LIRKHVQ.
    OrthoDBi EOG7J447H.
    PhylomeDBi P30280.
    TreeFami TF101004.

    Miscellaneous databases

    ChiTaRSi CCND2. mouse.
    NextBioi 281258.
    PROi P30280.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P30280.
    Bgeei P30280.
    CleanExi MM_CCND2.
    Genevestigatori P30280.

    Family and domain databases

    Gene3Di 1.10.472.10. 2 hits.
    InterProi IPR013763. Cyclin-like.
    IPR014400. Cyclin_A/B/D/E/F.
    IPR004367. Cyclin_C-dom.
    IPR015451. Cyclin_D.
    IPR006671. Cyclin_N.
    [Graphical view ]
    PANTHERi PTHR10177:SF66. PTHR10177:SF66. 1 hit.
    Pfami PF02984. Cyclin_C. 1 hit.
    PF00134. Cyclin_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001771. Cyclin_A_B_D_E. 1 hit.
    SMARTi SM00385. CYCLIN. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47954. SSF47954. 2 hits.
    PROSITEi PS00292. CYCLINS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Colony-stimulating factor 1 regulates novel cyclins during the G1 phase of the cell cycle."
      Matsushime H., Roussel M.F., Ashmun R.A., Sherr C.J.
      Cell 65:701-713(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6.
      Tissue: Brain.

    Entry informationi

    Entry nameiCCND2_MOUSE
    AccessioniPrimary (citable) accession number: P30280
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 1, 1993
    Last sequence update: April 1, 1993
    Last modified: October 1, 2014
    This is version 120 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3